NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2049844524|ref|NP_001382097|]
View 

transcription factor COE4 isoform 3 [Homo sapiens]

Protein Classification

IPT_COE and COE1_HLH domain-containing protein( domain architecture ID 10983367)

protein containing domains COE_DBD, IPT_COE, and COE1_HLH

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
COE_DBD super family cl17007
Colier/Olf/Early B-cell factor (EBF) DNA Binding Domain; COE_DBD is the amino-terminal DNA ...
 86-171 8.80e-67

Colier/Olf/Early B-cell factor (EBF) DNA Binding Domain; COE_DBD is the amino-terminal DNA binding domain of the COE protein family. The COE transcription factor is a regulator of development in several organs and tissues that contain the DBD domain as well as IPT/TIG (immunoglobulin-like, Plexins, transcription factors/transcription factor immunoglobulin) and basic helix-loop-helix (bHLH) domains. COE has four members in mammals (COE1-4) with high sequence similarity at the amino-terminal region. COE_DBD requires a zinc ion to bind DNA and contains a zinc finger motif (H-X(3)-C-X(2)-C-X(5)-C) termed the zinc knuckle. COE is homo- or heterodimerized through the bHLH domain to bind DNA. COE1-4 each has a variant due to alternative splicing. However, this alternative splicing does not occur at the DBD domain.


The actual alignment was detected with superfamily member pfam16422:

Pssm-ID: 450133  Cd Length: 227  Bit Score: 215.47  E-value: 8.80e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049844524  86 SRCCDRKSCGNRNETPSDPVIIDRFFLKFFLKCNQNCLKNAGNPRDMRRFQVVVSTTVSVDGHVLAVSDNMFVHNNSKHG 165
Cdd:pfam16422 142 SRCCDKKSCGNRNETPSDPVIIDRFFLKFFMKCNQNCLKNAGNPRDMRRFQVVVSTTVSVDGHVLAVSDNMFVHNNSKHG 221


                  ....*.
gi 2049844524 166 RRARRL 171
Cdd:pfam16422 222 RRARRL 227
IPT_COE cd01175
IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing ...
 179-263 1.50e-52

IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved in the regulation of the early stages of B-cell differentiation, Drosophila collier is a regulator of the head patterning, and a related protein in Xenopus is involved in primary neurogenesis. All COE family members have a well conserved DNA binding domain that contains an atypical Zn finger motif. The function of the IPT domain is unknown.


:

Pssm-ID: 238580  Cd Length: 85  Bit Score: 172.83  E-value: 1.50e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049844524 179 PCIKAISPGEGWTTGGATVIVIGDNFFDGLQVVFGNVLVWSELITPHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGCPGR 258
Cdd:cd01175     1 PCIKAISPSEGWTTGGATVIIIGDNFFDGLQVVFGTMLVWSELITPHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGTPGR 80


                  ....*
gi 2049844524 259 FVYTA 263
Cdd:cd01175    81 FVYTA 85
COE1_HLH pfam16423
Transcription factor COE1 helix-loop-helix domain; This is the helix-loop-helix domain of ...
 264-307 4.13e-25

Transcription factor COE1 helix-loop-helix domain; This is the helix-loop-helix domain of transcription factor COE1. It is responsible for dimerization.


:

Pssm-ID: 406751  Cd Length: 44  Bit Score: 97.55  E-value: 4.13e-25
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2049844524 264 LNEPTIDYGFQRLQKVIPRHPGDPERLPKEVLLKRAADLAEALY 307
Cdd:pfam16423   1 LNEPTIDYGFQRLQKLVPRHPGDPERLPKEIILKRAADLAEALY 44
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 334-496 1.97e-04

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.54  E-value: 1.97e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049844524  334 APGPLAPLAPSHPHPAVVGINAFSSPL-----AIAVGDATPGPEPGYARSCSSASPRGFAPsPGSQQSGYGGGLGAGLGG 408
Cdd:PHA03247  2711 APHALVSATPLPPGPAAARQASPALPAapappAVPAGPATPGGPARPARPPTTAGPPAPAP-PAAPAAGPPRRLTRPAVA 2789

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049844524  409 YGAPGVAGLGVPGSPS----FLNGSTATSPFAIMPSSPplAAASSMSLPAAAPTTSVFSFSPVNMISAVKQRSAFAPvlR 484
Cdd:PHA03247  2790 SLSESRESLPSPWDPAdppaAVLAPAAALPPAASPAGP--LPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRR--R 2865

                          170
                   ....*....|..
gi 2049844524  485 PPSSPPQACPRA 496
Cdd:PHA03247  2866 PPSRSPAAKPAA 2877
 
Name Accession Description Interval E-value
COE1_DBD pfam16422
Transcription factor COE1 DNA-binding domain;
86-171 8.80e-67

Transcription factor COE1 DNA-binding domain;


Pssm-ID: 435333  Cd Length: 227  Bit Score: 215.47  E-value: 8.80e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049844524  86 SRCCDRKSCGNRNETPSDPVIIDRFFLKFFLKCNQNCLKNAGNPRDMRRFQVVVSTTVSVDGHVLAVSDNMFVHNNSKHG 165
Cdd:pfam16422 142 SRCCDKKSCGNRNETPSDPVIIDRFFLKFFMKCNQNCLKNAGNPRDMRRFQVVVSTTVSVDGHVLAVSDNMFVHNNSKHG 221


                  ....*.
gi 2049844524 166 RRARRL 171
Cdd:pfam16422 222 RRARRL 227
COE_DBD cd11606
Colier/Olf/Early B-cell factor (EBF) DNA Binding Domain; COE_DBD is the amino-terminal DNA ...
 86-171 2.08e-62

Colier/Olf/Early B-cell factor (EBF) DNA Binding Domain; COE_DBD is the amino-terminal DNA binding domain of the COE protein family. The COE transcription factor is a regulator of development in several organs and tissues that contain the DBD domain as well as IPT/TIG (immunoglobulin-like, Plexins, transcription factors/transcription factor immunoglobulin) and basic helix-loop-helix (bHLH) domains. COE has four members in mammals (COE1-4) with high sequence similarity at the amino-terminal region. COE_DBD requires a zinc ion to bind DNA and contains a zinc finger motif (H-X(3)-C-X(2)-C-X(5)-C) termed the zinc knuckle. COE is homo- or heterodimerized through the bHLH domain to bind DNA. COE1-4 each has a variant due to alternative splicing. However, this alternative splicing does not occur at the DBD domain.


Pssm-ID: 212156  Cd Length: 212  Bit Score: 203.43  E-value: 2.08e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049844524  86 SRCCDRKSCGNRNETPSDPVIIDRFFLKFFLKCNQNCLKNAGNPRDMRRFQVVVSTTVSVDGHVLAVSDNMFVHNNSKHG 165
Cdd:cd11606   127 SRCCEKKSCGNRNETPSDPVIIDRFFLKFFLKCNQNCLKNAGNPRDMRRFQVVLSTTVNVDGHVLAVSDNMFVHNNSKHG 206


                  ....*.
gi 2049844524 166 RRARRL 171
Cdd:cd11606   207 RRARRL 212
IPT_COE cd01175
IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing ...
 179-263 1.50e-52

IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved in the regulation of the early stages of B-cell differentiation, Drosophila collier is a regulator of the head patterning, and a related protein in Xenopus is involved in primary neurogenesis. All COE family members have a well conserved DNA binding domain that contains an atypical Zn finger motif. The function of the IPT domain is unknown.


Pssm-ID: 238580  Cd Length: 85  Bit Score: 172.83  E-value: 1.50e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049844524 179 PCIKAISPGEGWTTGGATVIVIGDNFFDGLQVVFGNVLVWSELITPHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGCPGR 258
Cdd:cd01175     1 PCIKAISPSEGWTTGGATVIIIGDNFFDGLQVVFGTMLVWSELITPHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGTPGR 80


                  ....*
gi 2049844524 259 FVYTA 263
Cdd:cd01175    81 FVYTA 85
COE1_HLH pfam16423
Transcription factor COE1 helix-loop-helix domain; This is the helix-loop-helix domain of ...
 264-307 4.13e-25

Transcription factor COE1 helix-loop-helix domain; This is the helix-loop-helix domain of transcription factor COE1. It is responsible for dimerization.


Pssm-ID: 406751  Cd Length: 44  Bit Score: 97.55  E-value: 4.13e-25
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2049844524 264 LNEPTIDYGFQRLQKVIPRHPGDPERLPKEVLLKRAADLAEALY 307
Cdd:pfam16423   1 LNEPTIDYGFQRLQKLVPRHPGDPERLPKEIILKRAADLAEALY 44
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 179-261 1.19e-14

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 69.01  E-value: 1.19e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049844524 179 PCIKAISPGEGWTTGGATVIVIGDNF---FDGLQVVFGNVLVWSELITPHAIRVQTPPrHIPGVVEVTLSYKSKQFCKGc 255
Cdd:pfam01833   1 PVITSISPSSGPASGGTTITITGSNFgtdSSDLKVTIGGTPCTVISVSSTTIVCTTPP-GTSGLVNVSVTVGGGGISSS- 78


                  ....*.
gi 2049844524 256 PGRFVY 261
Cdd:pfam01833  79 PLTFTY 84
IPT smart00429
ig-like, plexins, transcription factors;
179-243 2.40e-05

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 42.79  E-value: 2.40e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2049844524  179 PCIKAISPGEGWTTGGATVIVIGDNFFDGlQVVFGNVLVWSELIT-----PHAIRVQTPPRH-IPGVVEVT 243
Cdd:smart00429   2 PVITRISPTSGPVSGGTEITLCGKNLKSI-SVVFVEVGVGEAPCTfspssSTAIVCKTPPYHnIPGSVPVR 71
PHA03247 PHA03247
large tegument protein UL36; Provisional
 334-496 1.97e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.54  E-value: 1.97e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049844524  334 APGPLAPLAPSHPHPAVVGINAFSSPL-----AIAVGDATPGPEPGYARSCSSASPRGFAPsPGSQQSGYGGGLGAGLGG 408
Cdd:PHA03247  2711 APHALVSATPLPPGPAAARQASPALPAapappAVPAGPATPGGPARPARPPTTAGPPAPAP-PAAPAAGPPRRLTRPAVA 2789

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049844524  409 YGAPGVAGLGVPGSPS----FLNGSTATSPFAIMPSSPplAAASSMSLPAAAPTTSVFSFSPVNMISAVKQRSAFAPvlR 484
Cdd:PHA03247  2790 SLSESRESLPSPWDPAdppaAVLAPAAALPPAASPAGP--LPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRR--R 2865

                          170
                   ....*....|..
gi 2049844524  485 PPSSPPQACPRA 496
Cdd:PHA03247  2866 PPSRSPAAKPAA 2877
 
Name Accession Description Interval E-value
COE1_DBD pfam16422
Transcription factor COE1 DNA-binding domain;
86-171 8.80e-67

Transcription factor COE1 DNA-binding domain;


Pssm-ID: 435333  Cd Length: 227  Bit Score: 215.47  E-value: 8.80e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049844524  86 SRCCDRKSCGNRNETPSDPVIIDRFFLKFFLKCNQNCLKNAGNPRDMRRFQVVVSTTVSVDGHVLAVSDNMFVHNNSKHG 165
Cdd:pfam16422 142 SRCCDKKSCGNRNETPSDPVIIDRFFLKFFMKCNQNCLKNAGNPRDMRRFQVVVSTTVSVDGHVLAVSDNMFVHNNSKHG 221


                  ....*.
gi 2049844524 166 RRARRL 171
Cdd:pfam16422 222 RRARRL 227
COE_DBD cd11606
Colier/Olf/Early B-cell factor (EBF) DNA Binding Domain; COE_DBD is the amino-terminal DNA ...
 86-171 2.08e-62

Colier/Olf/Early B-cell factor (EBF) DNA Binding Domain; COE_DBD is the amino-terminal DNA binding domain of the COE protein family. The COE transcription factor is a regulator of development in several organs and tissues that contain the DBD domain as well as IPT/TIG (immunoglobulin-like, Plexins, transcription factors/transcription factor immunoglobulin) and basic helix-loop-helix (bHLH) domains. COE has four members in mammals (COE1-4) with high sequence similarity at the amino-terminal region. COE_DBD requires a zinc ion to bind DNA and contains a zinc finger motif (H-X(3)-C-X(2)-C-X(5)-C) termed the zinc knuckle. COE is homo- or heterodimerized through the bHLH domain to bind DNA. COE1-4 each has a variant due to alternative splicing. However, this alternative splicing does not occur at the DBD domain.


Pssm-ID: 212156  Cd Length: 212  Bit Score: 203.43  E-value: 2.08e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049844524  86 SRCCDRKSCGNRNETPSDPVIIDRFFLKFFLKCNQNCLKNAGNPRDMRRFQVVVSTTVSVDGHVLAVSDNMFVHNNSKHG 165
Cdd:cd11606   127 SRCCEKKSCGNRNETPSDPVIIDRFFLKFFLKCNQNCLKNAGNPRDMRRFQVVLSTTVNVDGHVLAVSDNMFVHNNSKHG 206


                  ....*.
gi 2049844524 166 RRARRL 171
Cdd:cd11606   207 RRARRL 212
IPT_COE cd01175
IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing ...
 179-263 1.50e-52

IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved in the regulation of the early stages of B-cell differentiation, Drosophila collier is a regulator of the head patterning, and a related protein in Xenopus is involved in primary neurogenesis. All COE family members have a well conserved DNA binding domain that contains an atypical Zn finger motif. The function of the IPT domain is unknown.


Pssm-ID: 238580  Cd Length: 85  Bit Score: 172.83  E-value: 1.50e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049844524 179 PCIKAISPGEGWTTGGATVIVIGDNFFDGLQVVFGNVLVWSELITPHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGCPGR 258
Cdd:cd01175     1 PCIKAISPSEGWTTGGATVIIIGDNFFDGLQVVFGTMLVWSELITPHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGTPGR 80


                  ....*
gi 2049844524 259 FVYTA 263
Cdd:cd01175    81 FVYTA 85
COE1_HLH pfam16423
Transcription factor COE1 helix-loop-helix domain; This is the helix-loop-helix domain of ...
 264-307 4.13e-25

Transcription factor COE1 helix-loop-helix domain; This is the helix-loop-helix domain of transcription factor COE1. It is responsible for dimerization.


Pssm-ID: 406751  Cd Length: 44  Bit Score: 97.55  E-value: 4.13e-25
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2049844524 264 LNEPTIDYGFQRLQKVIPRHPGDPERLPKEVLLKRAADLAEALY 307
Cdd:pfam16423   1 LNEPTIDYGFQRLQKLVPRHPGDPERLPKEIILKRAADLAEALY 44
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 179-261 1.19e-14

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 69.01  E-value: 1.19e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049844524 179 PCIKAISPGEGWTTGGATVIVIGDNF---FDGLQVVFGNVLVWSELITPHAIRVQTPPrHIPGVVEVTLSYKSKQFCKGc 255
Cdd:pfam01833   1 PVITSISPSSGPASGGTTITITGSNFgtdSSDLKVTIGGTPCTVISVSSTTIVCTTPP-GTSGLVNVSVTVGGGGISSS- 78


                  ....*.
gi 2049844524 256 PGRFVY 261
Cdd:pfam01833  79 PLTFTY 84
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 179-262 1.66e-08

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 52.08  E-value: 1.66e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049844524 179 PCIKAISPGEGWTTGGATVIVIGDNFFDG--LQVVFGNVLVWSEL-ITPHAIRVQTPPRHI--PGVVEVTLSYKSkQFCK 253
Cdd:cd00102     1 PVITSISPSSGPVSGGTEVTITGSNFGSGsnLRVTFGGGVPCSVLsVSSTAIVCTTPPYANpgPGPVEVTVDRGN-GGIT 79


                  ....*....
gi 2049844524 254 GCPGRFVYT 262
Cdd:cd00102    80 SSPLTFTYV 88
IPT smart00429
ig-like, plexins, transcription factors;
179-243 2.40e-05

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 42.79  E-value: 2.40e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2049844524  179 PCIKAISPGEGWTTGGATVIVIGDNFFDGlQVVFGNVLVWSELIT-----PHAIRVQTPPRH-IPGVVEVT 243
Cdd:smart00429   2 PVITRISPTSGPVSGGTEITLCGKNLKSI-SVVFVEVGVGEAPCTfspssSTAIVCKTPPYHnIPGSVPVR 71
PHA03247 PHA03247
large tegument protein UL36; Provisional
 334-496 1.97e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.54  E-value: 1.97e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049844524  334 APGPLAPLAPSHPHPAVVGINAFSSPL-----AIAVGDATPGPEPGYARSCSSASPRGFAPsPGSQQSGYGGGLGAGLGG 408
Cdd:PHA03247  2711 APHALVSATPLPPGPAAARQASPALPAapappAVPAGPATPGGPARPARPPTTAGPPAPAP-PAAPAAGPPRRLTRPAVA 2789

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049844524  409 YGAPGVAGLGVPGSPS----FLNGSTATSPFAIMPSSPplAAASSMSLPAAAPTTSVFSFSPVNMISAVKQRSAFAPvlR 484
Cdd:PHA03247  2790 SLSESRESLPSPWDPAdppaAVLAPAAALPPAASPAGP--LPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRR--R 2865

                          170
                   ....*....|..
gi 2049844524  485 PPSSPPQACPRA 496
Cdd:PHA03247  2866 PPSRSPAAKPAA 2877
PHA03247 PHA03247
large tegument protein UL36; Provisional
 319-502 7.31e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.62  E-value: 7.31e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049844524  319 KRAADVAEALYSTPRAPGPLAPLAPSHPHPAVVGINAFSSPLAIAVGDATPGPEPGYARSCSSASPRGFAPSPGSQQSGY 398
Cdd:PHA03247  2759 RPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTA 2838

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2049844524  399 GGGLGAGLGGYGAPGvaGLGVPGSPSFLNGSTATSPfaIMPSSPPLAAASSMSLPAAAPTTSVFSFSPVNMisavkqrsa 478
Cdd:PHA03247  2839 PPPPPGPPPPSLPLG--GSVAPGGDVRRRPPSRSPA--AKPAAPARPPVRRLARPAVSRSTESFALPPDQP--------- 2905

                          170       180
                   ....*....|....*....|....
gi 2049844524  479 faPVLRPPSSPPQACPRAHGEGLP 502
Cdd:PHA03247  2906 --ERPPQPQAPPPPQPQPQPPPPP 2927
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH