general transcription factor IIH subunit 2 isoform a [Homo sapiens]
Protein Classification
VWA domain-containing protein( domain architecture ID 13419840)
VWA (von Willebrand factor type A) domain-containing protein
List of domain hits
| Name | Accession | Description | Interval | E-value | ||||||
| vWA_transcription_factor_IIH_type | cd01453 | Transcription factors IIH type: TFIIH is a multiprotein complex that is one of the five ... |
56-236 | 7.14e-107 | ||||||
Transcription factors IIH type: TFIIH is a multiprotein complex that is one of the five general transcription factors that binds RNA polymerase II holoenzyme. Orthologues of these genes are found in all completed eukaryotic genomes and all these proteins contain a VWA domain. The p44 subunit of TFIIH functions as a DNA helicase in RNA polymerase II transcription initiation and DNA repair, and its transcriptional activity is dependent on its C-terminal Zn-binding domains. The function of the vWA domain is unclear, but may be involved in complex assembly. The MIDAS motif is not conserved in this sub-group. : Pssm-ID: 238730 Cd Length: 183 Bit Score: 312.34 E-value: 7.14e-107
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| SSL1 super family | cl34921 | RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit ... |
11-385 | 3.44e-104 | ||||||
RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit SSL1 [Transcription / DNA replication, recombination, and repair]; The actual alignment was detected with superfamily member COG5151: Pssm-ID: 227480 [Multi-domain] Cd Length: 421 Bit Score: 314.24 E-value: 3.44e-104
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| Name | Accession | Description | Interval | E-value | ||||||
| vWA_transcription_factor_IIH_type | cd01453 | Transcription factors IIH type: TFIIH is a multiprotein complex that is one of the five ... |
56-236 | 7.14e-107 | ||||||
Transcription factors IIH type: TFIIH is a multiprotein complex that is one of the five general transcription factors that binds RNA polymerase II holoenzyme. Orthologues of these genes are found in all completed eukaryotic genomes and all these proteins contain a VWA domain. The p44 subunit of TFIIH functions as a DNA helicase in RNA polymerase II transcription initiation and DNA repair, and its transcriptional activity is dependent on its C-terminal Zn-binding domains. The function of the vWA domain is unclear, but may be involved in complex assembly. The MIDAS motif is not conserved in this sub-group. Pssm-ID: 238730 Cd Length: 183 Bit Score: 312.34 E-value: 7.14e-107
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| Ssl1 | pfam04056 | Ssl1-like; Ssl1-like proteins are 40kDa subunits of the Transcription factor II H complex. |
64-236 | 1.17e-104 | ||||||
Ssl1-like; Ssl1-like proteins are 40kDa subunits of the Transcription factor II H complex. Pssm-ID: 461149 Cd Length: 178 Bit Score: 306.28 E-value: 1.17e-104
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| SSL1 | COG5151 | RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit ... |
11-385 | 3.44e-104 | ||||||
RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit SSL1 [Transcription / DNA replication, recombination, and repair]; Pssm-ID: 227480 [Multi-domain] Cd Length: 421 Bit Score: 314.24 E-value: 3.44e-104
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| ssl1 | TIGR00622 | transcription factor ssl1; All proteins in this family for which functions are known are ... |
288-388 | 1.99e-57 | ||||||
transcription factor ssl1; All proteins in this family for which functions are known are components of the TFIIH complex which is involved in the initiaiton of transcription and nucleotide excision repair.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair] Pssm-ID: 129709 Cd Length: 112 Bit Score: 183.21 E-value: 1.99e-57
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| C1_4 | smart01047 | TFIIH C1-like domain; The carboxyl-terminal region of TFIIH is essential for transcription ... |
345-386 | 1.57e-16 | ||||||
TFIIH C1-like domain; The carboxyl-terminal region of TFIIH is essential for transcription activity. This regions binds three zinc atoms through two independent domain. The first contains a C4 zinc finger motif, whereas the second is characterised by a CX(2)CX(2-4)FCADCD motif. The solution structure of the second C-terminal domain revealed homology with the regulatory domain of protein kinase C. Pssm-ID: 214993 Cd Length: 49 Bit Score: 72.78 E-value: 1.57e-16
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| VWA | smart00327 | von Willebrand factor (vWF) type A domain; VWA domains in extracellular eukaryotic proteins ... |
60-227 | 4.80e-15 | ||||||
von Willebrand factor (vWF) type A domain; VWA domains in extracellular eukaryotic proteins mediate adhesion via metal ion-dependent adhesion sites (MIDAS). Intracellular VWA domains and homologues in prokaryotes have recently been identified. The proposed VWA domains in integrin beta subunits have recently been substantiated using sequence-based methods. Pssm-ID: 214621 [Multi-domain] Cd Length: 175 Bit Score: 72.49 E-value: 4.80e-15
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| C1_4 | pfam07975 | TFIIH C1-like domain; The carboxyl-terminal region of TFIIH is essential for transcription ... |
344-385 | 1.23e-12 | ||||||
TFIIH C1-like domain; The carboxyl-terminal region of TFIIH is essential for transcription activity. This regions binds three zinc atoms through two independent domain. The first contains a C4 zinc finger motif, whereas the second is characterized by a CX(2)CX(2-4)FCADCD motif. The solution structure of the second C-terminal domain revealed homology with the regulatory domain of protein kinase C (pfam00130). Pssm-ID: 336887 Cd Length: 55 Bit Score: 62.11 E-value: 1.23e-12
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| ChlD | COG1240 | vWFA (von Willebrand factor type A) domain of Mg and Co chelatases [Coenzyme transport and ... |
59-226 | 3.65e-09 | ||||||
vWFA (von Willebrand factor type A) domain of Mg and Co chelatases [Coenzyme transport and metabolism]; Pssm-ID: 440853 [Multi-domain] Cd Length: 262 Bit Score: 57.26 E-value: 3.65e-09
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| PLN03144 | PLN03144 | Carbon catabolite repressor protein 4 homolog; Provisional |
301-385 | 3.02e-03 | ||||||
Carbon catabolite repressor protein 4 homolog; Provisional Pssm-ID: 178689 [Multi-domain] Cd Length: 606 Bit Score: 39.71 E-value: 3.02e-03
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| Name | Accession | Description | Interval | E-value | ||||||
| vWA_transcription_factor_IIH_type | cd01453 | Transcription factors IIH type: TFIIH is a multiprotein complex that is one of the five ... |
56-236 | 7.14e-107 | ||||||
Transcription factors IIH type: TFIIH is a multiprotein complex that is one of the five general transcription factors that binds RNA polymerase II holoenzyme. Orthologues of these genes are found in all completed eukaryotic genomes and all these proteins contain a VWA domain. The p44 subunit of TFIIH functions as a DNA helicase in RNA polymerase II transcription initiation and DNA repair, and its transcriptional activity is dependent on its C-terminal Zn-binding domains. The function of the vWA domain is unclear, but may be involved in complex assembly. The MIDAS motif is not conserved in this sub-group. Pssm-ID: 238730 Cd Length: 183 Bit Score: 312.34 E-value: 7.14e-107
|
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| Ssl1 | pfam04056 | Ssl1-like; Ssl1-like proteins are 40kDa subunits of the Transcription factor II H complex. |
64-236 | 1.17e-104 | ||||||
Ssl1-like; Ssl1-like proteins are 40kDa subunits of the Transcription factor II H complex. Pssm-ID: 461149 Cd Length: 178 Bit Score: 306.28 E-value: 1.17e-104
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| SSL1 | COG5151 | RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit ... |
11-385 | 3.44e-104 | ||||||
RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit SSL1 [Transcription / DNA replication, recombination, and repair]; Pssm-ID: 227480 [Multi-domain] Cd Length: 421 Bit Score: 314.24 E-value: 3.44e-104
|
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| ssl1 | TIGR00622 | transcription factor ssl1; All proteins in this family for which functions are known are ... |
288-388 | 1.99e-57 | ||||||
transcription factor ssl1; All proteins in this family for which functions are known are components of the TFIIH complex which is involved in the initiaiton of transcription and nucleotide excision repair.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair] Pssm-ID: 129709 Cd Length: 112 Bit Score: 183.21 E-value: 1.99e-57
|
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| C1_4 | smart01047 | TFIIH C1-like domain; The carboxyl-terminal region of TFIIH is essential for transcription ... |
345-386 | 1.57e-16 | ||||||
TFIIH C1-like domain; The carboxyl-terminal region of TFIIH is essential for transcription activity. This regions binds three zinc atoms through two independent domain. The first contains a C4 zinc finger motif, whereas the second is characterised by a CX(2)CX(2-4)FCADCD motif. The solution structure of the second C-terminal domain revealed homology with the regulatory domain of protein kinase C. Pssm-ID: 214993 Cd Length: 49 Bit Score: 72.78 E-value: 1.57e-16
|
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| VWA | smart00327 | von Willebrand factor (vWF) type A domain; VWA domains in extracellular eukaryotic proteins ... |
60-227 | 4.80e-15 | ||||||
von Willebrand factor (vWF) type A domain; VWA domains in extracellular eukaryotic proteins mediate adhesion via metal ion-dependent adhesion sites (MIDAS). Intracellular VWA domains and homologues in prokaryotes have recently been identified. The proposed VWA domains in integrin beta subunits have recently been substantiated using sequence-based methods. Pssm-ID: 214621 [Multi-domain] Cd Length: 175 Bit Score: 72.49 E-value: 4.80e-15
|
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| C1_4 | pfam07975 | TFIIH C1-like domain; The carboxyl-terminal region of TFIIH is essential for transcription ... |
344-385 | 1.23e-12 | ||||||
TFIIH C1-like domain; The carboxyl-terminal region of TFIIH is essential for transcription activity. This regions binds three zinc atoms through two independent domain. The first contains a C4 zinc finger motif, whereas the second is characterized by a CX(2)CX(2-4)FCADCD motif. The solution structure of the second C-terminal domain revealed homology with the regulatory domain of protein kinase C (pfam00130). Pssm-ID: 336887 Cd Length: 55 Bit Score: 62.11 E-value: 1.23e-12
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| VWA_2 | pfam13519 | von Willebrand factor type A domain; |
61-170 | 4.03e-12 | ||||||
von Willebrand factor type A domain; Pssm-ID: 463909 [Multi-domain] Cd Length: 103 Bit Score: 62.31 E-value: 4.03e-12
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| vWFA | cd00198 | Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation ... |
59-205 | 2.97e-09 | ||||||
Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains. Pssm-ID: 238119 [Multi-domain] Cd Length: 161 Bit Score: 55.65 E-value: 2.97e-09
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| ChlD | COG1240 | vWFA (von Willebrand factor type A) domain of Mg and Co chelatases [Coenzyme transport and ... |
59-226 | 3.65e-09 | ||||||
vWFA (von Willebrand factor type A) domain of Mg and Co chelatases [Coenzyme transport and metabolism]; Pssm-ID: 440853 [Multi-domain] Cd Length: 262 Bit Score: 57.26 E-value: 3.65e-09
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| PLN03144 | PLN03144 | Carbon catabolite repressor protein 4 homolog; Provisional |
301-385 | 3.02e-03 | ||||||
Carbon catabolite repressor protein 4 homolog; Provisional Pssm-ID: 178689 [Multi-domain] Cd Length: 606 Bit Score: 39.71 E-value: 3.02e-03
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| VWA_26S_proteasome_subunit | cd01452 | 26S proteasome plays a major role in eukaryotic protein breakdown, especially for ... |
63-199 | 3.91e-03 | ||||||
26S proteasome plays a major role in eukaryotic protein breakdown, especially for ubiquitin-tagged proteins. It is an ATP-dependent protease responsible for the bulk of non-lysosomal proteolysis in eukaryotes, often using covalent modification of proteins by ubiquitylation. It consists of a 20S proteolytic core particle (CP) and a 19S regulatory particle (RP). The CP is an ATP independent peptidase consisting of hydrolyzing activities. One or both ends of CP carry the RP that confers both ubiquitin and ATP dependence to the 26S proteosome. The RP's proposed functions include recognition of substrates and translocation of these to CP for proteolysis. The RP can dissociate into a stable lid and base subcomplexes. The base is composed of three non-ATPase subunits (Rpn 1, 2 and 10). A single residue in the vWA domain of Rpn10 has been implicated to be responsible for stabilizing the lid-base association. Pssm-ID: 238729 Cd Length: 187 Bit Score: 38.11 E-value: 3.91e-03
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