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Conserved domains on  [gi|2086547934|ref|NP_001382826|]
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DNA polymerase kappa isoform 6 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PolY_Pol_IV_kappa cd03586
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion ...
 104-529 6.25e-145

DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Known primarily as Pol IV in prokaryotes and Pol kappa in eukaryotes, this polymerase has a propensity for generating frameshift mutations. The eukaryotic Pol kappa differs from Pol IV and Dpo4 by an N-terminal extension of ~75 residues known as the "N-clasp" region. The structure of Pol kappa shows DNA that is almost totally encircled by Pol kappa, with the N-clasp region augmenting the interactions between DNA and the polymerase. Pol kappa is more resistant than Pol eta and Pol iota to bulky guanine adducts and is efficient at catalyzing the incorporation of dCTP. Bacterial pol IV has a higher error rate than other Y-family polymerases.


:

Pssm-ID: 176459 [Multi-domain]  Cd Length: 334  Bit Score: 431.56  E-value: 6.25e-145
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 104 VHIDMDAFYAAVEMRDNPELKDKPIAVGSMSMLVCVffsmwsiffqSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPN 183
Cdd:cd03586     1 IHIDMDAFYASVEQRDNPELKGKPVAVGGSSDRGVV----------STASYEARKFGVRSAMPIFQAKKLCPNLIFVPPR 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 184 FDKYRAVSKEVKEILADYDPNFMAMSLDEAYLNITKHleerqnwpedkrryfikmgssvendnpgkevnklsehersisp 263
Cdd:cd03586    71 FDKYREVSRQIMEILREYTPLVEPLSIDEAYLDVTDY------------------------------------------- 107

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 264 llfeespsdvqppgdpfqvnfeeqnnpqilqnsVVFGTSAQEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPN 343
Cdd:cd03586   108 ---------------------------------VRLFGSATEIAKEIRARIREETGLTASAGIAPNKFLAKIASDLNKPN 154

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 344 GQYQILPnrQAVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELYQQRALLSLLFSETSWHYFLHISLGLGSTHLTRD 423
Cdd:cd03586   155 GLTVIPP--EDVEEFLAPLPVRKIPGVGKVTAEKLKELGIKTIGDLAKLDVELLKKLFGKSGRRLYELARGIDNRPVEPD 232

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 424 GERKSMSVERTFSE-INKAEEQYSLCQELCSELAQDLQKERLKGRTVTIKLKNVNFEVKTRASTVSSVVSTAEEIFAIAK 502
Cdd:cd03586   233 RERKSIGVERTFSEdLTDPEELLEELLELAEELAERLRKRGLKGRTVTVKLKYADFSTRTRSRTLPEPTDDAEDIYELAL 312

                         410       420
                  ....*....|....*....|....*..
gi 2086547934 503 ELLKTEIDadfphPLRLRLMGVRISSF 529
Cdd:cd03586   313 ELLEELLD-----GRPIRLLGVRLSGL 334
ZnF_Rad18 smart00734
Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative ...
 634-660 8.17e-05

Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative DNA repair. This zinc finger is likely to bind nucleic-acids.


:

Pssm-ID: 128973 [Multi-domain]  Cd Length: 24  Bit Score: 40.28  E-value: 8.17e-05
                           10        20
                   ....*....|....*....|....*..
gi 2086547934  634 ILTCPVCFRAQgciSLEALNKHVDECL 660
Cdd:smart00734   1 LVQCPVCFREV---PENLINSHLDSCL 24
ZnF_Rad18 super family cl42863
Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative ...
 789-815 2.20e-04

Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative DNA repair. This zinc finger is likely to bind nucleic-acids.


The actual alignment was detected with superfamily member smart00734:

Pssm-ID: 128973 [Multi-domain]  Cd Length: 24  Bit Score: 39.13  E-value: 2.20e-04
                           10        20
                   ....*....|....*....|....*..
gi 2086547934  789 ALVCPVCNVEQKtsdLTLFNVHVDVCL 815
Cdd:smart00734   1 LVQCPVCFREVP---ENLINSHLDSCL 24
 
Name Accession Description Interval E-value
PolY_Pol_IV_kappa cd03586
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion ...
 104-529 6.25e-145

DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Known primarily as Pol IV in prokaryotes and Pol kappa in eukaryotes, this polymerase has a propensity for generating frameshift mutations. The eukaryotic Pol kappa differs from Pol IV and Dpo4 by an N-terminal extension of ~75 residues known as the "N-clasp" region. The structure of Pol kappa shows DNA that is almost totally encircled by Pol kappa, with the N-clasp region augmenting the interactions between DNA and the polymerase. Pol kappa is more resistant than Pol eta and Pol iota to bulky guanine adducts and is efficient at catalyzing the incorporation of dCTP. Bacterial pol IV has a higher error rate than other Y-family polymerases.


Pssm-ID: 176459 [Multi-domain]  Cd Length: 334  Bit Score: 431.56  E-value: 6.25e-145
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 104 VHIDMDAFYAAVEMRDNPELKDKPIAVGSMSMLVCVffsmwsiffqSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPN 183
Cdd:cd03586     1 IHIDMDAFYASVEQRDNPELKGKPVAVGGSSDRGVV----------STASYEARKFGVRSAMPIFQAKKLCPNLIFVPPR 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 184 FDKYRAVSKEVKEILADYDPNFMAMSLDEAYLNITKHleerqnwpedkrryfikmgssvendnpgkevnklsehersisp 263
Cdd:cd03586    71 FDKYREVSRQIMEILREYTPLVEPLSIDEAYLDVTDY------------------------------------------- 107

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 264 llfeespsdvqppgdpfqvnfeeqnnpqilqnsVVFGTSAQEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPN 343
Cdd:cd03586   108 ---------------------------------VRLFGSATEIAKEIRARIREETGLTASAGIAPNKFLAKIASDLNKPN 154

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 344 GQYQILPnrQAVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELYQQRALLSLLFSETSWHYFLHISLGLGSTHLTRD 423
Cdd:cd03586   155 GLTVIPP--EDVEEFLAPLPVRKIPGVGKVTAEKLKELGIKTIGDLAKLDVELLKKLFGKSGRRLYELARGIDNRPVEPD 232

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 424 GERKSMSVERTFSE-INKAEEQYSLCQELCSELAQDLQKERLKGRTVTIKLKNVNFEVKTRASTVSSVVSTAEEIFAIAK 502
Cdd:cd03586   233 RERKSIGVERTFSEdLTDPEELLEELLELAEELAERLRKRGLKGRTVTVKLKYADFSTRTRSRTLPEPTDDAEDIYELAL 312

                         410       420
                  ....*....|....*....|....*..
gi 2086547934 503 ELLKTEIDadfphPLRLRLMGVRISSF 529
Cdd:cd03586   313 ELLEELLD-----GRPIRLLGVRLSGL 334
PRK02406 PRK02406
DNA polymerase IV; Validated
 108-535 2.70e-97

DNA polymerase IV; Validated


Pssm-ID: 235035 [Multi-domain]  Cd Length: 343  Bit Score: 308.20  E-value: 2.70e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 108 MDAFYAAVEMRDNPELKDKPIAVGsmsmlvcvffsmWS------IffqSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVP 181
Cdd:PRK02406    1 MDCFYAAVEMRDNPELRGKPVAVG------------GSpgrrgvI---STCNYEARKFGVRSAMPTAQALKLCPDLIFVP 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 182 PNFDKYRAVSKEVKEILADYDPNFMAMSLDEAYLNITkhleerqnwpedkrryfikmgssvenDNPgkevnklsehersi 261
Cdd:PRK02406   66 GRFDVYKEVSRQIREIFRRYTDLIEPLSLDEAYLDVT--------------------------DNK-------------- 105

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 262 spllfeespsdvQPPGdpfqvnfeeqnnpqilqnsvvfgtSAQEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNK 341
Cdd:PRK02406  106 ------------LCIG------------------------SATLIAQEIRQDIFEELGLTASAGVAPNKFLAKIASDWNK 149

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 342 PNGQYQILPNRqaVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELyQQRALLSLL-----FSetswHYFLHISLGLG 416
Cdd:PRK02406  150 PNGLFVITPEE--VDAFLATLPVEKIPGVGKVTAEKLHALGIYTCADL-QKYDLAELIrhfgkFG----RRLYERARGID 222

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 417 STHLTRDGERKSMSVERTFSE-INKAEEQYSLCQELCSELAQDLQKER--LKGRTVTIKLKNVNFEVKTRaSTVSSVVST 493
Cdd:PRK02406  223 ERPVKPDRERKSVGVERTFAEdLYDLEACLAELPRLAEKLERRLERAKpdKRIKTVGVKLKFADFQQTTK-EHTADPLDK 301

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|..
gi 2086547934 494 AEEIFAIAKELLKTEidadfpHPLRLRLMGVRISSFPNEEDR 535
Cdd:PRK02406  302 ADLIELLAQALLRRL------GGRGVRLLGVGVTLLEPQLER 337
DinP COG0389
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination ...
 102-527 8.27e-95

Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination and repair];


Pssm-ID: 440158 [Multi-domain]  Cd Length: 336  Bit Score: 301.29  E-value: 8.27e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 102 TIVHIDMDAFYAAVEMRDNPELKDKPIAVGSMSMLVCVffsmwsiffqSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVP 181
Cdd:COG0389     2 RILHVDMDAFYASVEQRDRPELRGKPVAVGGDNNRGVV----------AAASYEARAFGVRSGMPLFQARRLCPDLVVLP 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 182 PNFDKYRAVSKEVKEILADYDPNFMAMSLDEAYLNITkhleerqnwpeDKRRYFikmgssvendnpgkevnklsehersi 261
Cdd:COG0389    72 PDFELYRDVSRRVMAILERYTPLVEPLSIDEAFLDVT-----------GSARLF-------------------------- 114

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 262 spllfeespsdvqppgdpfqvnfeeqnnpqilqnsvvfgTSAQEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNK 341
Cdd:COG0389   115 ---------------------------------------GSAEAIARRIRRRIRRETGLTVSVGIAPNKFLAKIASDLAK 155

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 342 PNGQYQILPNRQAvmDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELYQQ-RALLSLLFSEtSWHYFLHISLGLGSTHL 420
Cdd:COG0389   156 PDGLTVIPPGEVA--AFLAPLPVEKLWGVGPKTAEKLARLGIRTIGDLAALpRAELRRRFGK-VGERLYRLARGIDPRPV 232

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 421 TRDGERKSMSVERTFSE-INKAEEQYSLCQELCSELAQDLQKERLKGRTVTIKLKNVNFEVKTRASTVSSVVSTAEEIFA 499
Cdd:COG0389   233 EPRRPRKSIGVERTFGEdLTDLEELEAALRRLAERLAERLRRQGLGARTVTVKLRTSDFRTTTRSRTLPEPTDDTAELLR 312

                         410       420
                  ....*....|....*....|....*...
gi 2086547934 500 IAKELLkteiDADFPHPLRLRLMGVRIS 527
Cdd:COG0389   313 AARELL----ERIYRPGRPVRLLGVRLS 336
IMS pfam00817
impB/mucB/samB family; These proteins are involved in UV protection (Swiss).
 106-338 2.00e-43

impB/mucB/samB family; These proteins are involved in UV protection (Swiss).


Pssm-ID: 425885 [Multi-domain]  Cd Length: 148  Bit Score: 154.27  E-value: 2.00e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 106 IDMDAFYAAVEMRDNPELKDKPIAVGSMSMLVCVffsmwsiffqSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFD 185
Cdd:pfam00817   1 IDMDAFFASVELLRDPELKGKPVAVGGGNGRGIV----------AAASYEARKYGVRSGMPVFEAKKLCPNLIVVPPDLE 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 186 KYRAVSKEVKEILADY-DPNFMAMSLDEAYLNITKHLEerqnwpedkrryfikmgssvendnpgkevnklsehersispl 264
Cdd:pfam00817  71 LYRRASRKIFEILRRFsTPKVEQASIDEAFLDLTGLEK------------------------------------------ 108

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2086547934 265 LFEespsdvqppgdpfqvnfeeqnnpqilqnsvvfgtSAQEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSD 338
Cdd:pfam00817 109 LFG----------------------------------AEEALAKRLRREIAEETGLTCSIGIAPNKLLAKLASD 148
ZnF_Rad18 smart00734
Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative ...
 634-660 8.17e-05

Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative DNA repair. This zinc finger is likely to bind nucleic-acids.


Pssm-ID: 128973 [Multi-domain]  Cd Length: 24  Bit Score: 40.28  E-value: 8.17e-05
                           10        20
                   ....*....|....*....|....*..
gi 2086547934  634 ILTCPVCFRAQgciSLEALNKHVDECL 660
Cdd:smart00734   1 LVQCPVCFREV---PENLINSHLDSCL 24
ZnF_Rad18 smart00734
Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative ...
 789-815 2.20e-04

Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative DNA repair. This zinc finger is likely to bind nucleic-acids.


Pssm-ID: 128973 [Multi-domain]  Cd Length: 24  Bit Score: 39.13  E-value: 2.20e-04
                           10        20
                   ....*....|....*....|....*..
gi 2086547934  789 ALVCPVCNVEQKtsdLTLFNVHVDVCL 815
Cdd:smart00734   1 LVQCPVCFREVP---ENLINSHLDSCL 24
 
Name Accession Description Interval E-value
PolY_Pol_IV_kappa cd03586
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion ...
 104-529 6.25e-145

DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Known primarily as Pol IV in prokaryotes and Pol kappa in eukaryotes, this polymerase has a propensity for generating frameshift mutations. The eukaryotic Pol kappa differs from Pol IV and Dpo4 by an N-terminal extension of ~75 residues known as the "N-clasp" region. The structure of Pol kappa shows DNA that is almost totally encircled by Pol kappa, with the N-clasp region augmenting the interactions between DNA and the polymerase. Pol kappa is more resistant than Pol eta and Pol iota to bulky guanine adducts and is efficient at catalyzing the incorporation of dCTP. Bacterial pol IV has a higher error rate than other Y-family polymerases.


Pssm-ID: 176459 [Multi-domain]  Cd Length: 334  Bit Score: 431.56  E-value: 6.25e-145
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 104 VHIDMDAFYAAVEMRDNPELKDKPIAVGSMSMLVCVffsmwsiffqSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPN 183
Cdd:cd03586     1 IHIDMDAFYASVEQRDNPELKGKPVAVGGSSDRGVV----------STASYEARKFGVRSAMPIFQAKKLCPNLIFVPPR 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 184 FDKYRAVSKEVKEILADYDPNFMAMSLDEAYLNITKHleerqnwpedkrryfikmgssvendnpgkevnklsehersisp 263
Cdd:cd03586    71 FDKYREVSRQIMEILREYTPLVEPLSIDEAYLDVTDY------------------------------------------- 107

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 264 llfeespsdvqppgdpfqvnfeeqnnpqilqnsVVFGTSAQEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPN 343
Cdd:cd03586   108 ---------------------------------VRLFGSATEIAKEIRARIREETGLTASAGIAPNKFLAKIASDLNKPN 154

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 344 GQYQILPnrQAVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELYQQRALLSLLFSETSWHYFLHISLGLGSTHLTRD 423
Cdd:cd03586   155 GLTVIPP--EDVEEFLAPLPVRKIPGVGKVTAEKLKELGIKTIGDLAKLDVELLKKLFGKSGRRLYELARGIDNRPVEPD 232

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 424 GERKSMSVERTFSE-INKAEEQYSLCQELCSELAQDLQKERLKGRTVTIKLKNVNFEVKTRASTVSSVVSTAEEIFAIAK 502
Cdd:cd03586   233 RERKSIGVERTFSEdLTDPEELLEELLELAEELAERLRKRGLKGRTVTVKLKYADFSTRTRSRTLPEPTDDAEDIYELAL 312

                         410       420
                  ....*....|....*....|....*..
gi 2086547934 503 ELLKTEIDadfphPLRLRLMGVRISSF 529
Cdd:cd03586   313 ELLEELLD-----GRPIRLLGVRLSGL 334
PRK02406 PRK02406
DNA polymerase IV; Validated
 108-535 2.70e-97

DNA polymerase IV; Validated


Pssm-ID: 235035 [Multi-domain]  Cd Length: 343  Bit Score: 308.20  E-value: 2.70e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 108 MDAFYAAVEMRDNPELKDKPIAVGsmsmlvcvffsmWS------IffqSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVP 181
Cdd:PRK02406    1 MDCFYAAVEMRDNPELRGKPVAVG------------GSpgrrgvI---STCNYEARKFGVRSAMPTAQALKLCPDLIFVP 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 182 PNFDKYRAVSKEVKEILADYDPNFMAMSLDEAYLNITkhleerqnwpedkrryfikmgssvenDNPgkevnklsehersi 261
Cdd:PRK02406   66 GRFDVYKEVSRQIREIFRRYTDLIEPLSLDEAYLDVT--------------------------DNK-------------- 105

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 262 spllfeespsdvQPPGdpfqvnfeeqnnpqilqnsvvfgtSAQEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNK 341
Cdd:PRK02406  106 ------------LCIG------------------------SATLIAQEIRQDIFEELGLTASAGVAPNKFLAKIASDWNK 149

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 342 PNGQYQILPNRqaVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELyQQRALLSLL-----FSetswHYFLHISLGLG 416
Cdd:PRK02406  150 PNGLFVITPEE--VDAFLATLPVEKIPGVGKVTAEKLHALGIYTCADL-QKYDLAELIrhfgkFG----RRLYERARGID 222

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 417 STHLTRDGERKSMSVERTFSE-INKAEEQYSLCQELCSELAQDLQKER--LKGRTVTIKLKNVNFEVKTRaSTVSSVVST 493
Cdd:PRK02406  223 ERPVKPDRERKSVGVERTFAEdLYDLEACLAELPRLAEKLERRLERAKpdKRIKTVGVKLKFADFQQTTK-EHTADPLDK 301

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|..
gi 2086547934 494 AEEIFAIAKELLKTEidadfpHPLRLRLMGVRISSFPNEEDR 535
Cdd:PRK02406  302 ADLIELLAQALLRRL------GGRGVRLLGVGVTLLEPQLER 337
DinP COG0389
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination ...
 102-527 8.27e-95

Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination and repair];


Pssm-ID: 440158 [Multi-domain]  Cd Length: 336  Bit Score: 301.29  E-value: 8.27e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 102 TIVHIDMDAFYAAVEMRDNPELKDKPIAVGSMSMLVCVffsmwsiffqSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVP 181
Cdd:COG0389     2 RILHVDMDAFYASVEQRDRPELRGKPVAVGGDNNRGVV----------AAASYEARAFGVRSGMPLFQARRLCPDLVVLP 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 182 PNFDKYRAVSKEVKEILADYDPNFMAMSLDEAYLNITkhleerqnwpeDKRRYFikmgssvendnpgkevnklsehersi 261
Cdd:COG0389    72 PDFELYRDVSRRVMAILERYTPLVEPLSIDEAFLDVT-----------GSARLF-------------------------- 114

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 262 spllfeespsdvqppgdpfqvnfeeqnnpqilqnsvvfgTSAQEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNK 341
Cdd:COG0389   115 ---------------------------------------GSAEAIARRIRRRIRRETGLTVSVGIAPNKFLAKIASDLAK 155

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 342 PNGQYQILPNRQAvmDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELYQQ-RALLSLLFSEtSWHYFLHISLGLGSTHL 420
Cdd:COG0389   156 PDGLTVIPPGEVA--AFLAPLPVEKLWGVGPKTAEKLARLGIRTIGDLAALpRAELRRRFGK-VGERLYRLARGIDPRPV 232

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 421 TRDGERKSMSVERTFSE-INKAEEQYSLCQELCSELAQDLQKERLKGRTVTIKLKNVNFEVKTRASTVSSVVSTAEEIFA 499
Cdd:COG0389   233 EPRRPRKSIGVERTFGEdLTDLEELEAALRRLAERLAERLRRQGLGARTVTVKLRTSDFRTTTRSRTLPEPTDDTAELLR 312

                         410       420
                  ....*....|....*....|....*...
gi 2086547934 500 IAKELLkteiDADFPHPLRLRLMGVRIS 527
Cdd:COG0389   313 AARELL----ERIYRPGRPVRLLGVRLS 336
PTZ00205 PTZ00205
DNA polymerase kappa; Provisional
 17-551 8.11e-81

DNA polymerase kappa; Provisional


Pssm-ID: 140232 [Multi-domain]  Cd Length: 571  Bit Score: 271.89  E-value: 8.11e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934  17 LRMGLNDNKAGMEGLDKEKINKIIMEATKGSRFYGNELKKEKQVNQRIENMMQQKAQIT--------SQQLRKAQLQVDR 88
Cdd:PTZ00205   42 FQLTLDCNKAGMGNVDKERVEAIIRNVSEGSSFLMNEQRLAEGREKQLQELKRKSSLFTqllggernAAQRKQWELKVSK 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934  89 FAMELEQSRNLSnTIVHIDMDAFYAAVEMRDNPELKDKPIAVGSMSMLvcvffsmwsiffqSTSNYHARRFGVRAAMPGF 168
Cdd:PTZ00205  122 IEQELEATRRLG-TYIHLDMDMFYAAVEIKKHPEYAAIPLAIGTMTML-------------QTANYVARGRGIRQGMPGF 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 169 IAKRLCPQLIIVPPNFDKYRAVSKEVKEILADYDPNFMAMSLDEAYLNITKHLEErqnwpedkrryfikmgssvendnpg 248
Cdd:PTZ00205  188 LALKICPNLLILPPDFDAYNEESNTVRRIVAEYDPNYISFGLDELTLEVSAYIER------------------------- 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 249 kevnklsehersispllFEespsdvqppgdpfqvnfeeqnnpqilqnsvvfGT-SAQEVVKEIRFRIEQKTTLTASAGIA 327
Cdd:PTZ00205  243 -----------------FE--------------------------------GTkTAEDVASELRVRVFGETKLTASAGIG 273

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 328 PNTMLAKVCSDKNKPNGQYQI-LPNRQAVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELYQQRALLSLLFSETSWH 406
Cdd:PTZ00205  274 PTAALAKIASNINKPNGQHDLnLHTRGDVMTYVRDLGLRSVPGVGKVTEALLKGLGITTLSDIYNRRVELCYILHNNLFR 353

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 407 YFLHISLGL------------GSTHLTRDGERKSMSVERTFSEINKAEEQYSLCQELCSELAQDLQKERLKGRTVTIKLK 474
Cdd:PTZ00205  354 FLLGASIGImqwpdaataantENCEGATGGQRKAISSERSFTTPRTKEGLQEMVDTVFNGAYEEMRKSELMCRQISLTIR 433

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 475 NVNFEVKTRASTVSSVVSTAEEIFAIAKELLkteidadFPHPLR---LRLMGVRISSFPNEEDRkHQQRsiigflQAGNQ 551
Cdd:PTZ00205  434 WASYRYQQYTKSLIQYSDDSATLRRAVDGLL-------LPHAAKyseMCLLGVRFLDLISAKDF-HMKR------KGGNQ 499
PRK14133 PRK14133
DNA polymerase IV; Provisional
 101-542 3.04e-64

DNA polymerase IV; Provisional


Pssm-ID: 184529 [Multi-domain]  Cd Length: 347  Bit Score: 219.59  E-value: 3.04e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 101 NTIVHIDMDAFYAAVEMRDNPELKDKPIAVGSMSMLVCVffsmwsiffqSTSNYHARRFGVRAAMPGFIAKRLCPQLIIV 180
Cdd:PRK14133    3 RVIIHVDMDAFFASVEQMDNPKLKGKPVIVGGISERGVV----------STCSYEARKYGVHSAMPVFMAKKRCPHGIFL 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 181 PPNFDKYRAVSKEVKEILADYDPNFMAMSLDEAYLNITkHLEErqnwpedkrryfikmgssvendnpgkevnklsehers 260
Cdd:PRK14133   73 PVRHERYKEVSKNIFKILYEVTPIVEPVSIDEAYLDIT-NIKE------------------------------------- 114

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 261 ispllfeespsdvqppgdpfqvnfeeqnNPQilqnsvvfgtsaqEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKN 340
Cdd:PRK14133  115 ----------------------------EPI-------------KIAKYIKKKVKKETGLTLSVGISYNKFLAKLASDWN 153

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 341 KPNGQYQIlpNRQAVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELYQ-QRALLSLLFSETSWHYFLHISlGLGSTH 419
Cdd:PRK14133  154 KPDGIKII--TEDMIPDILKPLPISKVHGIGKKSVEKLNNIGIYTIEDLLKlSREFLIEYFGKFGVEIYERIR-GIDYRE 230

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 420 LTRDGERKSMSVERTFS-EINKAEEQYSLCQELCSELAQDLQKERLKGRTVTIKLKNVNFEVKTRASTVSSVVSTAEEIF 498
Cdd:PRK14133  231 VEVSRERKSIGKETTLKkDTKDKEELKKYLKDFSNIISEELKKRNLYGKTVTVKIKTSDFQTHTKSKTLNDYIRDKEEIY 310

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....
gi 2086547934 499 AIAKELLKtEIDADFPhplrLRLMGVRISSFpneEDRKHQQRSI 542
Cdd:PRK14133  311 NVACEILE-HINIKEP----IRLIGLSVSNL---SENKIEQLSF 346
PRK02794 PRK02794
DNA polymerase IV; Provisional
 102-529 5.83e-63

DNA polymerase IV; Provisional


Pssm-ID: 179473 [Multi-domain]  Cd Length: 419  Bit Score: 218.65  E-value: 5.83e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 102 TIVHIDMDAFYAAVEMRDNPELKDKPIAVGSMSMLVCvffsmwsiffqSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVP 181
Cdd:PRK02794   37 SIAHIDCDAFYASVEKRDNPELRDKPVIIGGGKRGVV-----------STACYIARIHGVRSAMPMFKALKLCPDAVVIK 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 182 PNFDKYRAVSKEVKEILADYDPNFMAMSLDEAYLNitkhleerqnwpedkrryfikmgssvendnpgkevnkLSEHERsi 261
Cdd:PRK02794  106 PDMEKYVRVGREVRAMMQALTPLVEPLSIDEAFLD-------------------------------------LSGTER-- 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 262 spllfeespsdvqppgdpfqvnfeeqnnpqilqnsvVFGTSAQEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNK 341
Cdd:PRK02794  147 ------------------------------------LHGAPPAVVLARFARRVEREIGITVSVGLSYNKFLAKIASDLDK 190

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 342 PNGqYQILPNRQAVmDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELYQ--QRALLSLLFSETSWHYflHISLGLGSTH 419
Cdd:PRK02794  191 PRG-FSVIGRAEAL-AFLAPKPVGIIWGVGPATAARLARDGIRTIGDLQRadEADLMRRFGSMGLRLW--RLARGIDDRK 266

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 420 LTRDGERKSMSVERTFSE-INKAEEQYSLCQELCSELAQDLQKERLKGRTVTIKLKNVNFEVKTRASTVSSVVSTAEEIF 498
Cdd:PRK02794  267 VSPDREAKSVSAETTFETdLSDFEDLEPILWRLSEKVSRRLKAAGLAGRTVTLKLKTADFRLRTRRRTLEDPTQLADRIF 346

                         410       420       430
                  ....*....|....*....|....*....|.
gi 2086547934 499 AIAKELLKTEIDadfphPLRLRLMGVRISSF 529
Cdd:PRK02794  347 RTARELLEKETD-----GTAFRLIGIGVSDL 372
PRK03348 PRK03348
DNA polymerase IV; Provisional
 102-529 1.89e-50

DNA polymerase IV; Provisional


Pssm-ID: 235118 [Multi-domain]  Cd Length: 454  Bit Score: 184.37  E-value: 1.89e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 102 TIVHIDMDAFYAAVEMRDNPELKDKPIAVGSMSMLVCVffsmwsiffqSTSNYHARRFGVRAAMPGFIAKRLCPQL-IIV 180
Cdd:PRK03348    6 WVLHLDMDAFFASVEQLTRPTLRGRPVLVGGLGGRGVV----------AGASYEARVFGARSAMPMHQARRLVGNGaVVL 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 181 PPNFDKYRAVSKEVKEILADYDPNFMAMSLDEAYlnitkhleerqnwpedkrryfikmgssvendnpgkevnklsehers 260
Cdd:PRK03348   76 PPRFVVYRAASRRVFDTLRELSPVVEQLSFDEAF---------------------------------------------- 109

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 261 ispllfeespsdVQPPGdpfqvnfeeqnnpqilqnsvVFGTSAQEVVK---EIRFRIEQKTTLTASAGIAPNTMLAKVCS 337
Cdd:PRK03348  110 ------------VEPAE--------------------LAGASAEEVEAfaeRLRARVREETGLPASVGAGSGKQIAKIAS 157

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 338 DKNKPNGQYQILPNRQavMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELyqqRALlsllfSETSWHYFLHISLGLGS 417
Cdd:PRK03348  158 GLAKPDGIRVVPPGEE--RELLAPLPVRRLWGIGPVTEEKLHRLGIETIGDL---AAL-----SEAEVANLLGATVGPAL 227

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 418 THLTR---------DGERKSMSVERTF-SEINKAEEQYSLCQELCSELAQDLQKERLKGRTVTIKLKNVNFEVKTRASTV 487
Cdd:PRK03348  228 HRLARgiddrpvaeRAEAKQISAESTFaVDLTTRAQLREAIERIAEHAHRRLLKDGRGARTVTVKLRKSDFSTLTRSATL 307

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|..
gi 2086547934 488 SSVVSTAEEIFAIAKELLkteIDADFPHPlrLRLMGVRISSF 529
Cdd:PRK03348  308 PYATDDAAVLAATARRLL---LDPDEIGP--IRLVGVGFSGL 344
PolY cd00424
Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases ...
 104-527 1.40e-47

Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Most TLS polymerases are members of the Y-family, including Pol eta, Pol kappa/IV, Pol iota, Rev1, and Pol V, which is found exclusively in bacteria. In eukaryotes, the B-family polymerase Pol zeta also functions as a TLS polymerase. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention.


Pssm-ID: 176453 [Multi-domain]  Cd Length: 343  Bit Score: 172.93  E-value: 1.40e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 104 VHIDMDAFYAAVEMRDNPELKDKPIAV----GSMSMLVCVffsmwsiffqstsNYHARRFGVRAAMPGFIAKRLCPQLII 179
Cdd:cd00424     1 LHIDFDNFFASVEQLARPELKGRPVVVvpfnSDSTCVIAC-------------SYEARKYGVKRGMPVREARKMCPNLIL 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 180 VPPNFDKYRAVSKEVKEILADYDPNFMAMSLDEAYLNITKhleerqnwpedkrryfikmgssvendnpgkevnklseher 259
Cdd:cd00424    68 VPARLDLYRRLSERLLSELEEVAPLVEVASIDELFLDLTG---------------------------------------- 107

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 260 sispllfeespsdvqppgdpfqvnfeeqnnpqilqnSVVFGTSAQEVVKEIRFRIEQKT-TLTASAGIAPNTMLAKVCSD 338
Cdd:cd00424   108 ------------------------------------SARLLGLGSEVALRIKRHIAEQLgGITASIGIASNKLLAKLAAK 151

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 339 KNKPNGQYQILPnrQAVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELY--QQRALLSLLFSETS--WHYFLHislG 414
Cdd:cd00424   152 YAKPDGLTILDP--EDLPGFLSKLPLTDLPGIGAVTAKRLEAVGINPIGDLLaaSPDALLALWGGVSGerLWYALR---G 226

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 415 LGSTHLTRDGERKSMSVERTF-SEINKAEEQYSLCQELCSELAQDLQKERLKGRTVTIKLKNVN------FEVKTRASTV 487
Cdd:cd00424   227 IDDEPLSPPRPRKSFSHERVLpRDSRNAEDARPLLRLLLEKLARRLRRDGRGATRLRLWLRTVDgrwsghADIPSRSAPR 306

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|
gi 2086547934 488 SSVVSTaEEIFAIAKELLKTEIDAdfPHPLRLRLMGVRIS 527
Cdd:cd00424   307 PISTED-GELLHALDKLWRALLDD--KGPRRLRRLGVRLS 343
PRK01810 PRK01810
DNA polymerase IV; Validated
 100-524 5.67e-47

DNA polymerase IV; Validated


Pssm-ID: 179337 [Multi-domain]  Cd Length: 407  Bit Score: 173.29  E-value: 5.67e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 100 SNTIVHIDMDAFYAAVEMRDNPELKDKPIAV-GSMS----MLVcvffsmwsiffqsTSNYHARRFGVRAAMPGFIAKRLC 174
Cdd:PRK01810    4 GRVIFHVDMNSFFASVEIAYDPSLQGKPLAVaGNEKerkgIIV-------------TCSYEARAYGIRTTMPLWEAKRLC 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 175 PQLIIVPPNFDKYRAVSKEVKEILADYDPNFMAMSLDEAYLNITKHLEerqnwpedkrryfikmgssvendnpgkevnkl 254
Cdd:PRK01810   71 PQLIVRRPNFDRYREASRQMFQILSEFTPLVQPVSIDEGYLDITDCYA-------------------------------- 118

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 255 seherSISPLlfeespsdvqppgdpfqvnfeeqnnpqilqnsvvfgtsaqEVVKEIRFRIEQKTTLTASAGIAPNTMLAK 334
Cdd:PRK01810  119 -----LGSPL----------------------------------------EIAKMIQQRLLTELQLPCSIGIAPNKFLAK 153

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 335 VCSDKNKPNGqYQILPNRQaVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELYQ-QRALLSLLFSETswhyflhisl 413
Cdd:PRK01810  154 MASDMKKPLG-ITVLRKRD-VPEMLWPLPVGEMHGIGEKTAEKLKDIGIQTIGDLAKaDEHILRAKLGIN---------- 221

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 414 GL-------GSTHLTRDGER----KSMSVERTFSEiNKAEEQ--YSLCQELCSELAQDLQKERLKGRTVTIKLKNVNFEV 480
Cdd:PRK01810  222 GVrlqrranGIDDRPVDPEAiyqfKSVGNSTTLSH-DMDEEKelLDVLRRLSKSVSKRLQKKTVVSYNVQIMIRYHDRRT 300

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....
gi 2086547934 481 KTRASTVSSVVSTAEEIFAIAKELLKTEIDADfphplRLRLMGV 524
Cdd:PRK01810  301 ITRSKTLKNPIWEKRDIFQAASRLFKQHWNGD-----PVRLLGV 339
PRK03858 PRK03858
DNA polymerase IV; Validated
 102-539 8.20e-45

DNA polymerase IV; Validated


Pssm-ID: 179663 [Multi-domain]  Cd Length: 396  Bit Score: 166.70  E-value: 8.20e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 102 TIVHIDMDAFYAAVEMRDNPELKDKPIAVGSMSMLVCvffsmwsiffqstsNYHARRFGVRAAMPGFIAKRLCPQLIIVP 181
Cdd:PRK03858    5 SILHADLDSFYASVEQRDDPALRGRPVIVGGGVVLAA--------------SYEAKAYGVRTAMGGRQARRLCPQAVVVP 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 182 PNFDKYRAVSKEVKEILADYDPNFMAMSLDEAYLNITkhleerqnwpeDKRRyfikmgssvendnpgkevnklsehersi 261
Cdd:PRK03858   71 PRMSAYSRASKAVFEVFRDTTPLVEGLSIDEAFLDVG-----------GLRR---------------------------- 111

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 262 spllfeespsdvqppgdpfqvnfeeqnnpqilqnsvVFGTSAQeVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNK 341
Cdd:PRK03858  112 ------------------------------------ISGTPVQ-IAARLRRRVREEVGLPITVGVARTKFLAKVASQVAK 154

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 342 PNGQYQILPNRQavMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELYQ--QRALLSLLFSETSWHyfLH-ISLGLGST 418
Cdd:PRK03858  155 PDGLLVVPPDRE--LAFLHPLPVRRLWGVGPVTAAKLRAHGITTVGDVAElpESALVSLLGPAAGRH--LHaLAHNRDPR 230

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 419 HLTRDGERKSMSVERTFSEINKAEEQY--SLCQeLCSELAQDLQKERLKGRTVTIKLKNVNFEVKTRASTVSSVVSTAEE 496
Cdd:PRK03858  231 RVETGRRRRSVGAQRALGRGPNSPAEVdaVVVA-LVDRVARRMRAAGRTGRTVVLRLRFDDFTRATRSHTLPRPTASTAT 309

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*
gi 2086547934 497 IFAIAKELLkteiDADFP-HPLR-LRLMGVRISsfpNEEDRKHQQ 539
Cdd:PRK03858  310 LLAAARDLV----AAAAPlIAERgLTLVGFAVS---NLDDDGAQQ 347
PolY_Rev1 cd01701
DNA polymerase Rev1; Rev1 is a translesion synthesis (TLS) polymerase found in eukaryotes. ...
 81-527 1.77e-44

DNA polymerase Rev1; Rev1 is a translesion synthesis (TLS) polymerase found in eukaryotes. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Rev1 has both structural and enzymatic roles. Structurally, it is believed to interact with other nonclassical polymerases and replication machinery to act as a scaffold. Enzymatically, it catalyzes the specific insertion of dCMP opposite abasic sites. Rev1 interacts with the Rev7 subunit of the B-family TLS polymerase Pol zeta (Rev3/Rev7). Rev1 is known to actively promote the introduction of mutations, potentially making it a significant target for cancer treatment.


Pssm-ID: 176455 [Multi-domain]  Cd Length: 404  Bit Score: 165.95  E-value: 1.77e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934  81 KAQLQvDRFAMELEQSRN----------LSNTIVHIDMDAFYAAVEMRDNPELKDKPIAV----GSMSMLvcvffsmwsi 146
Cdd:cd01701    18 KARLK-DFFRELSNGSKEadpsnsihpdLQRIIMHVDFDCFFVSVSIRNRPDLKGKPVAVchgkGPNSEI---------- 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 147 ffqSTSNYHARRFGVRAAMpgFI--AKRLCPQLIIVPPNFDKYRAVSKEVKEILADYDPNFMAMSLDEAYLNITKHLEER 224
Cdd:cd01701    87 ---ASCNYEARSYGIKNGM--WVgqAKKLCPQLVTLPYDFEAYEEVSLTFYEILASYTDNIEAVSCDEALIDITSLLEET 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 225 QnwpedkrryfikmgssvendnpgkevnklsehersispllfeespsdvqppgdpfqvnfeeqnnpqilqnsvvfgTSAQ 304
Cdd:cd01701   162 Y---------------------------------------------------------------------------ELPE 166

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 305 EVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQILPnrQAVMDFIKDLPIRKVSGIGKVTEKMLKALGII 384
Cdd:cd01701   167 ELAEAIRNEIRETTGCSASVGIGPNILLARLATRKAKPDGQYHLSA--EKVEEFLSQLKVGDLPGVGSSLAEKLVKLFGD 244

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 385 TCTELYQQ----RALLSLLFSETSWHyFLHISLGLGSTHLTRDGERKSMSVertfsEIN------KAEEQYSLCQELCSE 454
Cdd:cd01701   245 TCGGLELRsktkEKLQKVLGPKTGEK-LYDYCRGIDDRPVTGEKERKSVSA-----EINygirftNVDDVEQFLQRLSEE 318

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 455 LAQDLQKERLKGRTVTIKLKN------------------VNFevkTRASTVSSVVSTAEEIFAIAKELLKTeIDADfphP 516
Cdd:cd01701   319 LSKRLEESNVTGRQITLKLMKrapgapieppkymghgicDSF---SKSSTLGVATDDSGVIGTEAKKLFRD-LSIP---P 391

                         490
                  ....*....|.
gi 2086547934 517 LRLRLMGVRIS 527
Cdd:cd01701   392 EELRGVGIQVT 402
IMS pfam00817
impB/mucB/samB family; These proteins are involved in UV protection (Swiss).
 106-338 2.00e-43

impB/mucB/samB family; These proteins are involved in UV protection (Swiss).


Pssm-ID: 425885 [Multi-domain]  Cd Length: 148  Bit Score: 154.27  E-value: 2.00e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 106 IDMDAFYAAVEMRDNPELKDKPIAVGSMSMLVCVffsmwsiffqSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFD 185
Cdd:pfam00817   1 IDMDAFFASVELLRDPELKGKPVAVGGGNGRGIV----------AAASYEARKYGVRSGMPVFEAKKLCPNLIVVPPDLE 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 186 KYRAVSKEVKEILADY-DPNFMAMSLDEAYLNITKHLEerqnwpedkrryfikmgssvendnpgkevnklsehersispl 264
Cdd:pfam00817  71 LYRRASRKIFEILRRFsTPKVEQASIDEAFLDLTGLEK------------------------------------------ 108

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2086547934 265 LFEespsdvqppgdpfqvnfeeqnnpqilqnsvvfgtSAQEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSD 338
Cdd:pfam00817 109 LFG----------------------------------AEEALAKRLRREIAEETGLTCSIGIAPNKLLAKLASD 148
PolY_Pol_eta cd01702
DNA Polymerase eta; Pol eta, also called Rad30A, is a translesion synthesis (TLS) polymerase. ...
 104-531 3.22e-34

DNA Polymerase eta; Pol eta, also called Rad30A, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Unlike other Y-family members, Pol eta can efficiently and accurately replicate DNA past UV-induced lesions. Its activity is initiated by two simultaneous interactions: the PIP box in pol eta interacting with PCNA, and the UBZ (ubiquitin-binding zinc finger) in pol eta interacting with monoubiquitin attached to PCNA. Pol eta is more efficient in copying damaged DNA than undamaged DNA and seems to recognize when a lesion has been passed, facilitating a lesion-dependent dissociation from the DNA.


Pssm-ID: 176456 [Multi-domain]  Cd Length: 359  Bit Score: 134.75  E-value: 3.22e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 104 VHIDMDAFYAAVEMRDNPELKDKPIAVGSMSMLVCVffsmwsiffqstsNYHARRFGVRAAMPGFIAKRLCPQLII--VP 181
Cdd:cd01702     1 AHIDMDAFFAQVEQVRLGLLRNDPVAVVQWNSIIAV-------------SYAARAFGVTRFMTIDEAKKKCPDLILahVA 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 182 P---------------------NFDKYRAVSKEVKEILADYDPNFMAMSLDEAYLNItkhleerqnwpedkrryfikmgs 240
Cdd:cd01702    68 TykkgedeadyhenpsparhkvSLDPYRRASRKILNILKRFGDVVEKASIDEAYLDL----------------------- 124

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 241 svendnpgkevnklsehersispllfeespsdvqppgdpfqvnfeeqnnpqilqnsvvfgtsAQEVVKEIRFRIEQKTTL 320
Cdd:cd01702   125 --------------------------------------------------------------GSRIVEEIRQQVYDELGY 142

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 321 TASAGIAPNTMLAKVCSDKNKPNGQyQILPNRqAVMDFIKDLPIRKVSGI-GKVTEKMLKALGIITCTELYQQRALLSLL 399
Cdd:cd01702   143 TCSAGIAHNKMLAKLASGMNKPNAQ-TILRND-AVASFLSSLPITSIRGLgGKLGEEIIDLLGLPTEGDVAGFRSSESDL 220

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 400 ---FSET--SWHYflHISLGLGSTHLTRDGERKSMSVERTFS-EINKAEEQ-YSLCQELCSELAQDLQKER----LKGRT 468
Cdd:cd01702   221 qehFGEKlgEWLY--NLLRGIDHEPVKPRPLPKSMGSSKNFPgKTALSTEDvQHWLLVLASELNSRLEDDRyennRRPKT 298

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2086547934 469 VTIKLKNVNFEVKTRASTVSSVVsTAEEIFAIAKELLKtEIDADFPHPLRLRLMGVRISSFPN 531
Cdd:cd01702   299 LVLSLRQRGDGVRRSRSCALPRY-DAQKIVKDAFKLIK-AINEEGLGLAWNYPLTLLSLSFTK 359
PRK03352 PRK03352
DNA polymerase IV; Validated
 103-533 3.53e-32

DNA polymerase IV; Validated


Pssm-ID: 179564 [Multi-domain]  Cd Length: 346  Bit Score: 128.60  E-value: 3.53e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 103 IVHIDMDAFYAAVEMRDNPELKDKPIAVGS------MSMLVcvffsmwsiffqSTSNYHARRFGVRAAMPGFIAKRLCPQ 176
Cdd:PRK03352    7 VLHVDLDQFIAAVELLRRPELAGLPVIVGGngdptePRKVV------------TCASYEARAFGVRAGMPLRTAARRCPD 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 177 LIIVPPNFDKYRAVSKEVKEILADYDPNFMAMSLDEAYLNITkhleerqnwpedkrryfikmgssvendnpgkevnklse 256
Cdd:PRK03352   75 AVFLPSDPAAYDAASEEVMATLRDLGVPVEVWGWDEAFLGVD-------------------------------------- 116

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 257 hersispllfeespsdvqpPGDPFqvnfeeqnnpqilqnsvvfgtsaqEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVC 336
Cdd:PRK03352  117 -------------------TDDPE------------------------ALAEEIRAAVLERTGLSCSVGIGDNKLRAKIA 153

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 337 SDKNKPNGQYQIlpNRQAVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTEL-YQQRALLSLLFSETSWHYFLHISLGL 415
Cdd:PRK03352  154 TGFAKPAGVFRL--TDANWMAVMGDRPTDALWGVGPKTAKRLAALGITTVADLaAADPAELAATFGPTTGPWLLLLARGG 231

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 416 GSTHLTRDG-ERKSMSVERTFSE-INKAEEQYSLCQELCSELAQDLQKE-RLKGRtVTIKLKNVNFEVKTRASTVSSVVS 492
Cdd:PRK03352  232 GDTEVSAEPwVPRSRSREVTFPQdLTDRAEVESAVRELARRVLDEVVAEgRPVTR-VAVKVRTATFYTRTKIRKLPEPTT 310

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|.
gi 2086547934 493 TAEEIFAIAKELLKtEIDADFPhplrLRLMGVRISSFPNEE 533
Cdd:PRK03352  311 DPDVIEAAALDVLD-RFELDRP----VRLLGVRLELAMPDE 346
PRK03103 PRK03103
DNA polymerase IV; Reviewed
 103-542 5.94e-31

DNA polymerase IV; Reviewed


Pssm-ID: 235104 [Multi-domain]  Cd Length: 409  Bit Score: 126.27  E-value: 5.94e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 103 IVHIDMDAFYAAVEMRDNPELKDKPIAVG------SMSMLvcvffsmwsiffqsTSNYHARRFGVRAAMPGFIAKRLCPQ 176
Cdd:PRK03103    5 ILLVDMQSFYASVEKAANPELKGRPVIVSgdperrSGVVL--------------AACPLAKAYGVKTAERLWEAQQKCPD 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 177 LIIVPPNFDKYRAVSKEVKEILADYDPNFMAMSLDEAYLNITkhleerqnwpedkrryfikmGSSvendnpgkevnklse 256
Cdd:PRK03103   71 LVVVKPRMQRYIDVSLQITRILEDFTDLVEPFSIDEQFLDVT--------------------GSQ--------------- 115

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 257 hersispLLFeespsdvqppGDPfqvnfeeqnnpqilqnsvvfgtsaQEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVC 336
Cdd:PRK03103  116 -------KLF----------GSP------------------------LEIAQKIQQRIMRETGVYARVGIGPNKLLAKMA 154

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 337 SD---KNKPNGQYQIlpNRQAVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELyqqrALLSLLFSETSW----HYFL 409
Cdd:PRK03103  155 CDnfaKKNPDGLFTL--DKEDVPADLWPLPVRKLFGVGSRMEKHLRRMGIRTIGQL----ANTPLERLKKRWgingEVLW 228

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 410 HISLGLGSTHLTRDG--ERKSMSVERTF-SEINKAEEQYSLCQELCSELAQDLQKERLKGRTVTIKLKNVNFEVKT---R 483
Cdd:PRK03103  229 RTANGIDYSPVTPHSldRQKAIGHQMTLpRDYRGFEEIKVVLLELCEEVCRRARAKGYMGRTVSVSLRGADFDWPTgfsR 308

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2086547934 484 ASTVSSVVSTAEEIFAIAKELLKTEIDAdfphpLRLRLMGVRISSF-PNEE------DRKHQQRSI 542
Cdd:PRK03103  309 QMTLPEPTNLAMEVYEAACKLFHRHWDG-----KPVRRVGVTLSNLvSDDVwqlslfGDRERKRSL 369
PRK01216 PRK01216
DNA polymerase IV; Validated
 103-383 1.15e-30

DNA polymerase IV; Validated


Pssm-ID: 179251 [Multi-domain]  Cd Length: 351  Bit Score: 124.13  E-value: 1.15e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 103 IVHIDMDAFYAAVEMRDNPELKDKPIavgsmsmLVCVFfsmwSIFFQ-----STSNYHARRFGVRAAMPGFIAKRLCPQL 177
Cdd:PRK01216    3 ILFVDFDYFFAQVEEVLNPSLKGKPV-------VVCVY----SGRFEdsgavATANYEARKLGIKAGMPIVEAKKILPNA 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 178 IIVPPNFDKYRAVSKEVKEILADYDPNFMAMSLDEAYLNITKHLEerqnwpedkrryfikmgssvendnpgkevnklseh 257
Cdd:PRK01216   72 VYLPMRKEVYQQVSNRIMKLLREYSEKIEIASIDEAYLDISDKVK----------------------------------- 116

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 258 ersispllfeespsdvqppgdpfqvNFEEqnnpqilqnsvvfgtsAQEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCS 337
Cdd:PRK01216  117 -------------------------NYQD----------------AYNLGLEIKNKILEKEKITVTVGISKNKVFAKIAA 155

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 2086547934 338 DKNKPNGQYQILPnrQAVMDFIKDLPIRKVSGIGKVTEKMLKALGI 383
Cdd:PRK01216  156 DMAKPNGIKVIDD--EEVKRFINELDIADIPGIGDITAEKLKKLGV 199
PolY_Pol_iota cd01703
DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. ...
 104-524 4.10e-30

DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol iota is thought to be one of the least efficient polymerases, particularly when opposite pyrimidines; it can incorporate the correct nucleotide opposite a purine much more efficiently than opposite a pyrimidine, and prefers to insert guanosine instead of adenosine opposite thymidine. Pol iota is believed to use Hoogsteen rather than Watson-Crick base pairing, which may explain the varying efficiency for different template nucleotides.


Pssm-ID: 176457 [Multi-domain]  Cd Length: 379  Bit Score: 123.35  E-value: 4.10e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 104 VHIDMDAFYAAVEMRDNPELKDKPIAVGSMSMLVcvffsmwsiffqsTSNYHARRFGVRAAMPGFIAKRLCPQLIIVP-P 182
Cdd:cd01703     1 IHLDLDCFYAQVEEIRDPSLKSKPLGIQQKYIVV-------------TCNYEARRLGVKKLMSIKDAKEICPDLVLVNgE 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 183 NFDKYRAVSKEVKEILADYDPNFMA--MSLDEAYLNITkhleerqnwpeDKRryfikmgssvendnpgkevnklsehers 260
Cdd:cd01703    68 DLTPFRDMSKKVYRLLRSYSWNDRVerLGFDENFMDVT-----------EMR---------------------------- 108

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 261 ispLLFeespsdvqppgdpfqvnfeeqnnpqilqnsvvfgtsAQEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKN 340
Cdd:cd01703   109 ---LLV------------------------------------ASHIAYEMRERIENELGLTCCAGIASNKLLAKLVGSVN 149

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 341 KPNGQYQILP-NRQAVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELyQQRALLSLLFSETSWHYFLHISLGLG--- 416
Cdd:cd01703   150 KPNQQTTLLPpSCADLMDFMDLHDLRKIPGIGYKTAAKLEAHGISSVRDL-QEFSNRNRQTVGAAPSLLELLLMVKEfge 228

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 417 --STHLT-----RDGER--------KSMSVERTF-----SEINKAEEQYS---------LCQELCSELAQDLQKERLKGR 467
Cdd:cd01703   229 giGQRIWkllfgRDTSPvkpasdfpQQISIEDSYkkcslEEIREARNKIEellasllerMKQDLQEVKAGDGRRPHTLRL 308

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2086547934 468 TV---TIKLKNVNFEVKTrASTVSSVVST--------AEEIFAIAKELLKTEIDADFPHPLRLRLMGV 524
Cdd:cd01703   309 TLrryTSTKKHYNRESKQ-APIPSHVFQKltggneiaARPIEKILMRLFRELVPPKNVKGFNLTLLNV 375
PolY_Pol_V_umuC cd01700
umuC subunit of DNA Polymerase V; umuC subunit of Pol V. Pol V is a bacterial translesion ...
 106-471 3.61e-24

umuC subunit of DNA Polymerase V; umuC subunit of Pol V. Pol V is a bacterial translesion synthesis (TLS) polymerase that consists of the heterotrimer of one umuC and two umuD subunits. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol V, RecA, single stranded DNA-binding protein, beta sliding clamp, and gamma clamp loading complex are responsible for inducing the SOS response in bacteria to repair UV-induced DNA damage.


Pssm-ID: 176454 [Multi-domain]  Cd Length: 344  Bit Score: 104.94  E-value: 3.61e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 106 IDMDAFYAAVEMRDNPELKDKPIAVGSMSMLVCVffsmwsiffqsTSNYHARRFGVRAAMPGFIAKRLCPQL--IIVPPN 183
Cdd:cd01700     3 VDCNSFYASCERVFRPLLLGRPLVVLSNNDGCVI-----------ARSPEAKALGIKMGSPYFKVPDLLERHgvAVFSSN 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 184 FDKYRAVSKEVKEILADYDPNFMAMSLDEAYLNITkhleerqnwpedkrryfikmgssvendnpgkevnklsehersisp 263
Cdd:cd01700    72 YALYGDMSRRIMSILERFSPDVEVYSIDESFLDLT--------------------------------------------- 106

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 264 llfeespsDVQPPGDPfqvnfeeqnnpqilqnsvvfgtsaQEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSD----K 339
Cdd:cd01700   107 --------GSLRFGDL------------------------EELARKIRRRILQETGIPVTVGIGPTKTLAKLANDlakkK 154

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 340 NKPNGQYQIL--PNRQAVMdfiKDLPIRKVSGIGKVTEKMLKALGIIT-----CTELYQQRALLSLLFSETSWHyfLH-I 411
Cdd:cd01700   155 NPYGGVVDLTdeEVRDKLL---KILPVGDVWGIGRRTAKKLNAMGIHTagdlaQADPDLLRKKFGVVGERLVRE--LNgI 229

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2086547934 412 S-LGLGSTHltrdGERKSMSVERTFSE-INKAEEQYSLCQELCSELAQDLQKERLKGRTVTI 471
Cdd:cd01700   230 DcLPLEEYP----PPKKSIGSSRSFGRdVTDLDELKQALAEYAERAAEKLRRQKSVARTISV 287
IMS_C pfam11799
impB/mucB/samB family C-terminal domain; These proteins are involved in UV protection (Swiss).
 426-533 7.62e-22

impB/mucB/samB family C-terminal domain; These proteins are involved in UV protection (Swiss).


Pssm-ID: 463354 [Multi-domain]  Cd Length: 104  Bit Score: 91.08  E-value: 7.62e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 426 RKSMSVERTFSE-INKAEEQYSLCQELCSELAQDLQKERLKGRTVTIKLKNVNFEVKTRASTVSSVVSTAEEIFAIAKEL 504
Cdd:pfam11799   1 RKSIGAERTFGRdLTDLEELREALLELAEELAERLRRQGLVARTVTVKIRYSDFRTITRSVTLPSPTDDTDEIYRAALRL 80

                          90       100
                  ....*....|....*....|....*....
gi 2086547934 505 LKteidaDFPHPLRLRLMGVRISSFPNEE 533
Cdd:pfam11799  81 LR-----RLYRGRPVRLLGVSLSNLVPEG 104
IMS_HHH pfam11798
IMS family HHH motif; These proteins are involved in UV protection, eg.
 352-383 9.13e-07

IMS family HHH motif; These proteins are involved in UV protection, eg.


Pssm-ID: 432081 [Multi-domain]  Cd Length: 32  Bit Score: 45.85  E-value: 9.13e-07
                          10        20        30
                  ....*....|....*....|....*....|..
gi 2086547934 352 RQAVMDFIKDLPIRKVSGIGKVTEKMLKALGI 383
Cdd:pfam11798   1 PDDVPEFLWPLPISKIPGIGKKLAEKLKALGI 32
ZnF_Rad18 smart00734
Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative ...
 634-660 8.17e-05

Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative DNA repair. This zinc finger is likely to bind nucleic-acids.


Pssm-ID: 128973 [Multi-domain]  Cd Length: 24  Bit Score: 40.28  E-value: 8.17e-05
                           10        20
                   ....*....|....*....|....*..
gi 2086547934  634 ILTCPVCFRAQgciSLEALNKHVDECL 660
Cdd:smart00734   1 LVQCPVCFREV---PENLINSHLDSCL 24
ZnF_Rad18 smart00734
Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative ...
 789-815 2.20e-04

Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative DNA repair. This zinc finger is likely to bind nucleic-acids.


Pssm-ID: 128973 [Multi-domain]  Cd Length: 24  Bit Score: 39.13  E-value: 2.20e-04
                           10        20
                   ....*....|....*....|....*..
gi 2086547934  789 ALVCPVCNVEQKtsdLTLFNVHVDVCL 815
Cdd:smart00734   1 LVQCPVCFREVP---ENLINSHLDSCL 24
PolY_like cd03468
DNA Polymerase Y-family; Y-family DNA polymerases are a specialized subset of polymerases that ...
 310-506 4.32e-04

DNA Polymerase Y-family; Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention.


Pssm-ID: 176458 [Multi-domain]  Cd Length: 335  Bit Score: 43.52  E-value: 4.32e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 310 IRFRIEQKTT-LTASAGIAPNTMLAKVCSDKNKPNGQYQIlPNRQAVMDFIKDLPIRkVSGIGKVTEKMLKALGIIT--- 385
Cdd:cd03468   119 ASLRAALATLgLSARAGIADTPGAAWLLARAGGGRGVLRR-EALAAALVLLAPLPVA-ALRLPPETVELLARLGLRTlgd 196

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 386 CTELYqqRALLSLLFSE--TSWHYFLhislgLGSTHLTRDG----ERKSMSVERTFsEINKAEEQYSLCQELCSELAQDL 459
Cdd:cd03468   197 LAALP--RAELARRFGLalLLRLDQA-----YGRDPEPLLFspppPAFDFRLELQL-EEPIARGLLFPLRRLLEQLCAFL 268

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 2086547934 460 QKERLKGRTVTIKLKNVNFEVKTRASTVSSVVSTAEEIFAIAKELLK 506
Cdd:cd03468   269 ALRGLGARRLSLTLFREDGRVTRVLVGLARPSRDDLPLLRLLRERLE 315
umuC PRK03609
translesion error-prone DNA polymerase V subunit UmuC;
105-392 5.73e-04

translesion error-prone DNA polymerase V subunit UmuC;


Pssm-ID: 179607 [Multi-domain]  Cd Length: 422  Bit Score: 43.22  E-value: 5.73e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 105 HIDMDAFYAAVEMRDNPELKDKPIAVGSMSMlVCVFfsmwsiffqsTSNYHARRFGVRAAMPGFIAK--RLCPQLIIVPP 182
Cdd:PRK03609    4 LCDVNSFYASCETVFRPDLRGKPVVVLSNND-GCVI----------ARSAEAKALGIKMGDPWFKQKdlFRRCGVVCFSS 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 183 NFDKYRAVSKEVKEILADYDPNFMAMSLDEAYLNITkhleerqnwpedkrryfikmgsSVENdnpgkevnklsehersis 262
Cdd:PRK03609   73 NYELYADMSNRVMSTLEELSPRVEIYSIDEAFCDLT----------------------GVRN------------------ 112

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547934 263 pllfeespsdvqppgdpfQVNFEEqnnpqilqnsvvFGtsaqevvKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKP 342
Cdd:PRK03609  113 ------------------CRDLTD------------FG-------REIRATVLQRTHLTVGVGIAQTKTLAKLANHAAKK 155

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2086547934 343 ----NGQYQILPNRQAVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELYQQ 392
Cdd:PRK03609  156 wqrqTGGVVDLSNLERQRKLLSLQPVEEVWGVGRRISKKLNAMGIKTALDLADT 209
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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