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Conserved domains on  [gi|2086547931|ref|NP_001382829|]
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DNA polymerase kappa isoform 2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PolY_Pol_IV_kappa cd03586
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion ...
 38-450 1.95e-149

DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Known primarily as Pol IV in prokaryotes and Pol kappa in eukaryotes, this polymerase has a propensity for generating frameshift mutations. The eukaryotic Pol kappa differs from Pol IV and Dpo4 by an N-terminal extension of ~75 residues known as the "N-clasp" region. The structure of Pol kappa shows DNA that is almost totally encircled by Pol kappa, with the N-clasp region augmenting the interactions between DNA and the polymerase. Pol kappa is more resistant than Pol eta and Pol iota to bulky guanine adducts and is efficient at catalyzing the incorporation of dCTP. Bacterial pol IV has a higher error rate than other Y-family polymerases.


:

Pssm-ID: 176459 [Multi-domain]  Cd Length: 334  Bit Score: 440.80  E-value: 1.95e-149
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931  38 VHIDMDAFYAAVEMRDNPELKDKPIAVGSMS---MLSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSKE 114
Cdd:cd03586     1 IHIDMDAFYASVEQRDNPELKGKPVAVGGSSdrgVVSTASYEARKFGVRSAMPIFQAKKLCPNLIFVPPRFDKYREVSRQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931 115 VKEILADYDPNFMAMSLDEAYLNITKHleerqnwpedkrryfikmgssvendnpgkevnklsehersispllfeespsdv 194
Cdd:cd03586    81 IMEILREYTPLVEPLSIDEAYLDVTDY----------------------------------------------------- 107

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931 195 qppgdpfqvnfeeqnnpqilqnsVVFGTSAQEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQILPnrQ 274
Cdd:cd03586   108 -----------------------VRLFGSATEIAKEIRARIREETGLTASAGIAPNKFLAKIASDLNKPNGLTVIPP--E 162

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931 275 AVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELYQQRALLSLLFSETSWHYFLHISLGLGSTHLTRDGERKSMSVER 354
Cdd:cd03586   163 DVEEFLAPLPVRKIPGVGKVTAEKLKELGIKTIGDLAKLDVELLKKLFGKSGRRLYELARGIDNRPVEPDRERKSIGVER 242

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931 355 TFSE-INKAEEQYSLCQELCSELAQDLQKERLKGRTVTIKLKNVNFEVKTRASTVSSVVSTAEEIFAIAKELLKTEIDad 433
Cdd:cd03586   243 TFSEdLTDPEELLEELLELAEELAERLRKRGLKGRTVTVKLKYADFSTRTRSRTLPEPTDDAEDIYELALELLEELLD-- 320

                         410
                  ....*....|....*..
gi 2086547931 434 fphPLRLRLMGVRISSF 450
Cdd:cd03586   321 ---GRPIRLLGVRLSGL 334
ZnF_Rad18 smart00734
Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative ...
 555-581 8.81e-05

Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative DNA repair. This zinc finger is likely to bind nucleic-acids.


:

Pssm-ID: 128973 [Multi-domain]  Cd Length: 24  Bit Score: 39.90  E-value: 8.81e-05
                           10        20
                   ....*....|....*....|....*..
gi 2086547931  555 ILTCPVCFRAQgciSLEALNKHVDECL 581
Cdd:smart00734   1 LVQCPVCFREV---PENLINSHLDSCL 24
ZnF_Rad18 super family cl42863
Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative ...
 710-736 2.35e-04

Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative DNA repair. This zinc finger is likely to bind nucleic-acids.


The actual alignment was detected with superfamily member smart00734:

Pssm-ID: 128973 [Multi-domain]  Cd Length: 24  Bit Score: 38.74  E-value: 2.35e-04
                           10        20
                   ....*....|....*....|....*..
gi 2086547931  710 ALVCPVCNVEQKtsdLTLFNVHVDVCL 736
Cdd:smart00734   1 LVQCPVCFREVP---ENLINSHLDSCL 24
 
Name Accession Description Interval E-value
PolY_Pol_IV_kappa cd03586
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion ...
 38-450 1.95e-149

DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Known primarily as Pol IV in prokaryotes and Pol kappa in eukaryotes, this polymerase has a propensity for generating frameshift mutations. The eukaryotic Pol kappa differs from Pol IV and Dpo4 by an N-terminal extension of ~75 residues known as the "N-clasp" region. The structure of Pol kappa shows DNA that is almost totally encircled by Pol kappa, with the N-clasp region augmenting the interactions between DNA and the polymerase. Pol kappa is more resistant than Pol eta and Pol iota to bulky guanine adducts and is efficient at catalyzing the incorporation of dCTP. Bacterial pol IV has a higher error rate than other Y-family polymerases.


Pssm-ID: 176459 [Multi-domain]  Cd Length: 334  Bit Score: 440.80  E-value: 1.95e-149
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931  38 VHIDMDAFYAAVEMRDNPELKDKPIAVGSMS---MLSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSKE 114
Cdd:cd03586     1 IHIDMDAFYASVEQRDNPELKGKPVAVGGSSdrgVVSTASYEARKFGVRSAMPIFQAKKLCPNLIFVPPRFDKYREVSRQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931 115 VKEILADYDPNFMAMSLDEAYLNITKHleerqnwpedkrryfikmgssvendnpgkevnklsehersispllfeespsdv 194
Cdd:cd03586    81 IMEILREYTPLVEPLSIDEAYLDVTDY----------------------------------------------------- 107

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931 195 qppgdpfqvnfeeqnnpqilqnsVVFGTSAQEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQILPnrQ 274
Cdd:cd03586   108 -----------------------VRLFGSATEIAKEIRARIREETGLTASAGIAPNKFLAKIASDLNKPNGLTVIPP--E 162

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931 275 AVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELYQQRALLSLLFSETSWHYFLHISLGLGSTHLTRDGERKSMSVER 354
Cdd:cd03586   163 DVEEFLAPLPVRKIPGVGKVTAEKLKELGIKTIGDLAKLDVELLKKLFGKSGRRLYELARGIDNRPVEPDRERKSIGVER 242

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931 355 TFSE-INKAEEQYSLCQELCSELAQDLQKERLKGRTVTIKLKNVNFEVKTRASTVSSVVSTAEEIFAIAKELLKTEIDad 433
Cdd:cd03586   243 TFSEdLTDPEELLEELLELAEELAERLRKRGLKGRTVTVKLKYADFSTRTRSRTLPEPTDDAEDIYELALELLEELLD-- 320

                         410
                  ....*....|....*..
gi 2086547931 434 fphPLRLRLMGVRISSF 450
Cdd:cd03586   321 ---GRPIRLLGVRLSGL 334
PRK02406 PRK02406
DNA polymerase IV; Validated
 42-456 1.45e-100

DNA polymerase IV; Validated


Pssm-ID: 235035 [Multi-domain]  Cd Length: 343  Bit Score: 314.75  E-value: 1.45e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931  42 MDAFYAAVEMRDNPELKDKPIAVGS----MSMLSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSKEVKE 117
Cdd:PRK02406    1 MDCFYAAVEMRDNPELRGKPVAVGGspgrRGVISTCNYEARKFGVRSAMPTAQALKLCPDLIFVPGRFDVYKEVSRQIRE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931 118 ILADYDPNFMAMSLDEAYLNITkhleerqnwpedkrryfikmgssvenDNPgkevnklsehersispllfeespsdvQPP 197
Cdd:PRK02406   81 IFRRYTDLIEPLSLDEAYLDVT--------------------------DNK--------------------------LCI 108

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931 198 GdpfqvnfeeqnnpqilqnsvvfgtSAQEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQILPNRqaVM 277
Cdd:PRK02406  109 G------------------------SATLIAQEIRQDIFEELGLTASAGVAPNKFLAKIASDWNKPNGLFVITPEE--VD 162

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931 278 DFIKDLPIRKVSGIGKVTEKMLKALGIITCTELyQQRALLSLL-----FSetswHYFLHISLGLGSTHLTRDGERKSMSV 352
Cdd:PRK02406  163 AFLATLPVEKIPGVGKVTAEKLHALGIYTCADL-QKYDLAELIrhfgkFG----RRLYERARGIDERPVKPDRERKSVGV 237

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931 353 ERTFSE-INKAEEQYSLCQELCSELAQDLQKER--LKGRTVTIKLKNVNFEVKTRaSTVSSVVSTAEEIFAIAKELLKTE 429
Cdd:PRK02406  238 ERTFAEdLYDLEACLAELPRLAEKLERRLERAKpdKRIKTVGVKLKFADFQQTTK-EHTADPLDKADLIELLAQALLRRL 316

                         410       420
                  ....*....|....*....|....*..
gi 2086547931 430 idadfpHPLRLRLMGVRISSFPNEEDR 456
Cdd:PRK02406  317 ------GGRGVRLLGVGVTLLEPQLER 337
DinP COG0389
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination ...
 36-448 9.14e-97

Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination and repair];


Pssm-ID: 440158 [Multi-domain]  Cd Length: 336  Bit Score: 304.76  E-value: 9.14e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931  36 TIVHIDMDAFYAAVEMRDNPELKDKPIAVGSMSM---LSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVS 112
Cdd:COG0389     2 RILHVDMDAFYASVEQRDRPELRGKPVAVGGDNNrgvVAAASYEARAFGVRSGMPLFQARRLCPDLVVLPPDFELYRDVS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931 113 KEVKEILADYDPNFMAMSLDEAYLNITkhleerqnwpeDKRRYFikmgssvendnpgkevnklsehersispllfeesps 192
Cdd:COG0389    82 RRVMAILERYTPLVEPLSIDEAFLDVT-----------GSARLF------------------------------------ 114

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931 193 dvqppgdpfqvnfeeqnnpqilqnsvvfgTSAQEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQILPN 272
Cdd:COG0389   115 -----------------------------GSAEAIARRIRRRIRRETGLTVSVGIAPNKFLAKIASDLAKPDGLTVIPPG 165

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931 273 RQAvmDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELYQQ-RALLSLLFSEtSWHYFLHISLGLGSTHLTRDGERKSMS 351
Cdd:COG0389   166 EVA--AFLAPLPVEKLWGVGPKTAEKLARLGIRTIGDLAALpRAELRRRFGK-VGERLYRLARGIDPRPVEPRRPRKSIG 242

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931 352 VERTFSE-INKAEEQYSLCQELCSELAQDLQKERLKGRTVTIKLKNVNFEVKTRASTVSSVVSTAEEIFAIAKELLktei 430
Cdd:COG0389   243 VERTFGEdLTDLEELEAALRRLAERLAERLRRQGLGARTVTVKLRTSDFRTTTRSRTLPEPTDDTAELLRAARELL---- 318

                         410
                  ....*....|....*...
gi 2086547931 431 DADFPHPLRLRLMGVRIS 448
Cdd:COG0389   319 ERIYRPGRPVRLLGVRLS 336
IMS pfam00817
impB/mucB/samB family; These proteins are involved in UV protection (Swiss).
 40-259 4.02e-46

impB/mucB/samB family; These proteins are involved in UV protection (Swiss).


Pssm-ID: 425885 [Multi-domain]  Cd Length: 148  Bit Score: 161.59  E-value: 4.02e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931  40 IDMDAFYAAVEMRDNPELKDKPIAVGS---MSMLSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSKEVK 116
Cdd:pfam00817   1 IDMDAFFASVELLRDPELKGKPVAVGGgngRGIVAAASYEARKYGVRSGMPVFEAKKLCPNLIVVPPDLELYRRASRKIF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931 117 EILADY-DPNFMAMSLDEAYLNITKHLEerqnwpedkrryfikmgssvendnpgkevnklsehersisplLFEespsdvq 195
Cdd:pfam00817  81 EILRRFsTPKVEQASIDEAFLDLTGLEK------------------------------------------LFG------- 111

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2086547931 196 ppgdpfqvnfeeqnnpqilqnsvvfgtSAQEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSD 259
Cdd:pfam00817 112 ---------------------------AEEALAKRLRREIAEETGLTCSIGIAPNKLLAKLASD 148
ZnF_Rad18 smart00734
Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative ...
 555-581 8.81e-05

Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative DNA repair. This zinc finger is likely to bind nucleic-acids.


Pssm-ID: 128973 [Multi-domain]  Cd Length: 24  Bit Score: 39.90  E-value: 8.81e-05
                           10        20
                   ....*....|....*....|....*..
gi 2086547931  555 ILTCPVCFRAQgciSLEALNKHVDECL 581
Cdd:smart00734   1 LVQCPVCFREV---PENLINSHLDSCL 24
ZnF_Rad18 smart00734
Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative ...
 710-736 2.35e-04

Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative DNA repair. This zinc finger is likely to bind nucleic-acids.


Pssm-ID: 128973 [Multi-domain]  Cd Length: 24  Bit Score: 38.74  E-value: 2.35e-04
                           10        20
                   ....*....|....*....|....*..
gi 2086547931  710 ALVCPVCNVEQKtsdLTLFNVHVDVCL 736
Cdd:smart00734   1 LVQCPVCFREVP---ENLINSHLDSCL 24
 
Name Accession Description Interval E-value
PolY_Pol_IV_kappa cd03586
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion ...
 38-450 1.95e-149

DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Known primarily as Pol IV in prokaryotes and Pol kappa in eukaryotes, this polymerase has a propensity for generating frameshift mutations. The eukaryotic Pol kappa differs from Pol IV and Dpo4 by an N-terminal extension of ~75 residues known as the "N-clasp" region. The structure of Pol kappa shows DNA that is almost totally encircled by Pol kappa, with the N-clasp region augmenting the interactions between DNA and the polymerase. Pol kappa is more resistant than Pol eta and Pol iota to bulky guanine adducts and is efficient at catalyzing the incorporation of dCTP. Bacterial pol IV has a higher error rate than other Y-family polymerases.


Pssm-ID: 176459 [Multi-domain]  Cd Length: 334  Bit Score: 440.80  E-value: 1.95e-149
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931  38 VHIDMDAFYAAVEMRDNPELKDKPIAVGSMS---MLSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSKE 114
Cdd:cd03586     1 IHIDMDAFYASVEQRDNPELKGKPVAVGGSSdrgVVSTASYEARKFGVRSAMPIFQAKKLCPNLIFVPPRFDKYREVSRQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931 115 VKEILADYDPNFMAMSLDEAYLNITKHleerqnwpedkrryfikmgssvendnpgkevnklsehersispllfeespsdv 194
Cdd:cd03586    81 IMEILREYTPLVEPLSIDEAYLDVTDY----------------------------------------------------- 107

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931 195 qppgdpfqvnfeeqnnpqilqnsVVFGTSAQEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQILPnrQ 274
Cdd:cd03586   108 -----------------------VRLFGSATEIAKEIRARIREETGLTASAGIAPNKFLAKIASDLNKPNGLTVIPP--E 162

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931 275 AVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELYQQRALLSLLFSETSWHYFLHISLGLGSTHLTRDGERKSMSVER 354
Cdd:cd03586   163 DVEEFLAPLPVRKIPGVGKVTAEKLKELGIKTIGDLAKLDVELLKKLFGKSGRRLYELARGIDNRPVEPDRERKSIGVER 242

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931 355 TFSE-INKAEEQYSLCQELCSELAQDLQKERLKGRTVTIKLKNVNFEVKTRASTVSSVVSTAEEIFAIAKELLKTEIDad 433
Cdd:cd03586   243 TFSEdLTDPEELLEELLELAEELAERLRKRGLKGRTVTVKLKYADFSTRTRSRTLPEPTDDAEDIYELALELLEELLD-- 320

                         410
                  ....*....|....*..
gi 2086547931 434 fphPLRLRLMGVRISSF 450
Cdd:cd03586   321 ---GRPIRLLGVRLSGL 334
PRK02406 PRK02406
DNA polymerase IV; Validated
 42-456 1.45e-100

DNA polymerase IV; Validated


Pssm-ID: 235035 [Multi-domain]  Cd Length: 343  Bit Score: 314.75  E-value: 1.45e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931  42 MDAFYAAVEMRDNPELKDKPIAVGS----MSMLSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSKEVKE 117
Cdd:PRK02406    1 MDCFYAAVEMRDNPELRGKPVAVGGspgrRGVISTCNYEARKFGVRSAMPTAQALKLCPDLIFVPGRFDVYKEVSRQIRE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931 118 ILADYDPNFMAMSLDEAYLNITkhleerqnwpedkrryfikmgssvenDNPgkevnklsehersispllfeespsdvQPP 197
Cdd:PRK02406   81 IFRRYTDLIEPLSLDEAYLDVT--------------------------DNK--------------------------LCI 108

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931 198 GdpfqvnfeeqnnpqilqnsvvfgtSAQEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQILPNRqaVM 277
Cdd:PRK02406  109 G------------------------SATLIAQEIRQDIFEELGLTASAGVAPNKFLAKIASDWNKPNGLFVITPEE--VD 162

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931 278 DFIKDLPIRKVSGIGKVTEKMLKALGIITCTELyQQRALLSLL-----FSetswHYFLHISLGLGSTHLTRDGERKSMSV 352
Cdd:PRK02406  163 AFLATLPVEKIPGVGKVTAEKLHALGIYTCADL-QKYDLAELIrhfgkFG----RRLYERARGIDERPVKPDRERKSVGV 237

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931 353 ERTFSE-INKAEEQYSLCQELCSELAQDLQKER--LKGRTVTIKLKNVNFEVKTRaSTVSSVVSTAEEIFAIAKELLKTE 429
Cdd:PRK02406  238 ERTFAEdLYDLEACLAELPRLAEKLERRLERAKpdKRIKTVGVKLKFADFQQTTK-EHTADPLDKADLIELLAQALLRRL 316

                         410       420
                  ....*....|....*....|....*..
gi 2086547931 430 idadfpHPLRLRLMGVRISSFPNEEDR 456
Cdd:PRK02406  317 ------GGRGVRLLGVGVTLLEPQLER 337
DinP COG0389
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination ...
 36-448 9.14e-97

Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination and repair];


Pssm-ID: 440158 [Multi-domain]  Cd Length: 336  Bit Score: 304.76  E-value: 9.14e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931  36 TIVHIDMDAFYAAVEMRDNPELKDKPIAVGSMSM---LSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVS 112
Cdd:COG0389     2 RILHVDMDAFYASVEQRDRPELRGKPVAVGGDNNrgvVAAASYEARAFGVRSGMPLFQARRLCPDLVVLPPDFELYRDVS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931 113 KEVKEILADYDPNFMAMSLDEAYLNITkhleerqnwpeDKRRYFikmgssvendnpgkevnklsehersispllfeesps 192
Cdd:COG0389    82 RRVMAILERYTPLVEPLSIDEAFLDVT-----------GSARLF------------------------------------ 114

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931 193 dvqppgdpfqvnfeeqnnpqilqnsvvfgTSAQEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQILPN 272
Cdd:COG0389   115 -----------------------------GSAEAIARRIRRRIRRETGLTVSVGIAPNKFLAKIASDLAKPDGLTVIPPG 165

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931 273 RQAvmDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELYQQ-RALLSLLFSEtSWHYFLHISLGLGSTHLTRDGERKSMS 351
Cdd:COG0389   166 EVA--AFLAPLPVEKLWGVGPKTAEKLARLGIRTIGDLAALpRAELRRRFGK-VGERLYRLARGIDPRPVEPRRPRKSIG 242

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931 352 VERTFSE-INKAEEQYSLCQELCSELAQDLQKERLKGRTVTIKLKNVNFEVKTRASTVSSVVSTAEEIFAIAKELLktei 430
Cdd:COG0389   243 VERTFGEdLTDLEELEAALRRLAERLAERLRRQGLGARTVTVKLRTSDFRTTTRSRTLPEPTDDTAELLRAARELL---- 318

                         410
                  ....*....|....*...
gi 2086547931 431 DADFPHPLRLRLMGVRIS 448
Cdd:COG0389   319 ERIYRPGRPVRLLGVRLS 336
PTZ00205 PTZ00205
DNA polymerase kappa; Provisional
 12-472 1.12e-73

DNA polymerase kappa; Provisional


Pssm-ID: 140232 [Multi-domain]  Cd Length: 571  Bit Score: 251.09  E-value: 1.12e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931  12 QLRKAQLQVDRFAMELEQSRNLSnTIVHIDMDAFYAAVEMRDNPELKDKPIAVGSMSMLSTSNYHARRFGVRAAMPGFIA 91
Cdd:PTZ00205  111 QRKQWELKVSKIEQELEATRRLG-TYIHLDMDMFYAAVEIKKHPEYAAIPLAIGTMTMLQTANYVARGRGIRQGMPGFLA 189

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931  92 KRLCPQLIIVPPNFDKYRAVSKEVKEILADYDPNFMAMSLDEAYLNITKHLEErqnwpedkrryfikmgssvendnpgke 171
Cdd:PTZ00205  190 LKICPNLLILPPDFDAYNEESNTVRRIVAEYDPNYISFGLDELTLEVSAYIER--------------------------- 242

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931 172 vnklsehersispllFEespsdvqppgdpfqvnfeeqnnpqilqnsvvfGT-SAQEVVKEIRFRIEQKTTLTASAGIAPN 250
Cdd:PTZ00205  243 ---------------FE--------------------------------GTkTAEDVASELRVRVFGETKLTASAGIGPT 275

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931 251 TMLAKVCSDKNKPNGQYQI-LPNRQAVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELYQQRALLSLLFSETSWHYF 329
Cdd:PTZ00205  276 AALAKIASNINKPNGQHDLnLHTRGDVMTYVRDLGLRSVPGVGKVTEALLKGLGITTLSDIYNRRVELCYILHNNLFRFL 355

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931 330 LHISLGL------------GSTHLTRDGERKSMSVERTFSEINKAEEQYSLCQELCSELAQDLQKERLKGRTVTIKLKNV 397
Cdd:PTZ00205  356 LGASIGImqwpdaataantENCEGATGGQRKAISSERSFTTPRTKEGLQEMVDTVFNGAYEEMRKSELMCRQISLTIRWA 435

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2086547931 398 NFEVKTRASTVSSVVSTAEEIFAIAKELLkteidadFPHPLR---LRLMGVRISSFPNEEDRkHQQRsiigflQAGNQ 472
Cdd:PTZ00205  436 SYRYQQYTKSLIQYSDDSATLRRAVDGLL-------LPHAAKyseMCLLGVRFLDLISAKDF-HMKR------KGGNQ 499
PRK14133 PRK14133
DNA polymerase IV; Provisional
 35-463 4.33e-67

DNA polymerase IV; Provisional


Pssm-ID: 184529 [Multi-domain]  Cd Length: 347  Bit Score: 226.14  E-value: 4.33e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931  35 NTIVHIDMDAFYAAVEMRDNPELKDKPIAVGSMS---MLSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAV 111
Cdd:PRK14133    3 RVIIHVDMDAFFASVEQMDNPKLKGKPVIVGGISergVVSTCSYEARKYGVHSAMPVFMAKKRCPHGIFLPVRHERYKEV 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931 112 SKEVKEILADYDPNFMAMSLDEAYLNITkHLEErqnwpedkrryfikmgssvendnpgkevnklsehersispllfeesp 191
Cdd:PRK14133   83 SKNIFKILYEVTPIVEPVSIDEAYLDIT-NIKE----------------------------------------------- 114

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931 192 sdvqppgdpfqvnfeeqnNPQilqnsvvfgtsaqEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQIlp 271
Cdd:PRK14133  115 ------------------EPI-------------KIAKYIKKKVKKETGLTLSVGISYNKFLAKLASDWNKPDGIKII-- 161

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931 272 NRQAVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELYQ-QRALLSLLFSETSWHYFLHISlGLGSTHLTRDGERKSM 350
Cdd:PRK14133  162 TEDMIPDILKPLPISKVHGIGKKSVEKLNNIGIYTIEDLLKlSREFLIEYFGKFGVEIYERIR-GIDYREVEVSRERKSI 240

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931 351 SVERTFS-EINKAEEQYSLCQELCSELAQDLQKERLKGRTVTIKLKNVNFEVKTRASTVSSVVSTAEEIFAIAKELLKtE 429
Cdd:PRK14133  241 GKETTLKkDTKDKEELKKYLKDFSNIISEELKKRNLYGKTVTVKIKTSDFQTHTKSKTLNDYIRDKEEIYNVACEILE-H 319

                         410       420       430
                  ....*....|....*....|....*....|....
gi 2086547931 430 IDADFPhplrLRLMGVRISSFpneEDRKHQQRSI 463
Cdd:PRK14133  320 INIKEP----IRLIGLSVSNL---SENKIEQLSF 346
PRK02794 PRK02794
DNA polymerase IV; Provisional
 36-450 3.10e-65

DNA polymerase IV; Provisional


Pssm-ID: 179473 [Multi-domain]  Cd Length: 419  Bit Score: 223.66  E-value: 3.10e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931  36 TIVHIDMDAFYAAVEMRDNPELKDKPIAVG--SMSMLSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSK 113
Cdd:PRK02794   37 SIAHIDCDAFYASVEKRDNPELRDKPVIIGggKRGVVSTACYIARIHGVRSAMPMFKALKLCPDAVVIKPDMEKYVRVGR 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931 114 EVKEILADYDPNFMAMSLDEAYLNitkhleerqnwpedkrryfikmgssvendnpgkevnkLSEHERsispllfeespsd 193
Cdd:PRK02794  117 EVRAMMQALTPLVEPLSIDEAFLD-------------------------------------LSGTER------------- 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931 194 vqppgdpfqvnfeeqnnpqilqnsvVFGTSAQEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGqYQILPNR 273
Cdd:PRK02794  147 -------------------------LHGAPPAVVLARFARRVEREIGITVSVGLSYNKFLAKIASDLDKPRG-FSVIGRA 200

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931 274 QAVmDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELYQ--QRALLSLLFSETSWHYflHISLGLGSTHLTRDGERKSMS 351
Cdd:PRK02794  201 EAL-AFLAPKPVGIIWGVGPATAARLARDGIRTIGDLQRadEADLMRRFGSMGLRLW--RLARGIDDRKVSPDREAKSVS 277

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931 352 VERTFSE-INKAEEQYSLCQELCSELAQDLQKERLKGRTVTIKLKNVNFEVKTRASTVSSVVSTAEEIFAIAKELLKTEI 430
Cdd:PRK02794  278 AETTFETdLSDFEDLEPILWRLSEKVSRRLKAAGLAGRTVTLKLKTADFRLRTRRRTLEDPTQLADRIFRTARELLEKET 357

                         410       420
                  ....*....|....*....|
gi 2086547931 431 DadfphPLRLRLMGVRISSF 450
Cdd:PRK02794  358 D-----GTAFRLIGIGVSDL 372
PRK03348 PRK03348
DNA polymerase IV; Provisional
 36-450 1.04e-52

DNA polymerase IV; Provisional


Pssm-ID: 235118 [Multi-domain]  Cd Length: 454  Bit Score: 190.15  E-value: 1.04e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931  36 TIVHIDMDAFYAAVEMRDNPELKDKPIAVGSMS---MLSTSNYHARRFGVRAAMPGFIAKRLCPQL-IIVPPNFDKYRAV 111
Cdd:PRK03348    6 WVLHLDMDAFFASVEQLTRPTLRGRPVLVGGLGgrgVVAGASYEARVFGARSAMPMHQARRLVGNGaVVLPPRFVVYRAA 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931 112 SKEVKEILADYDPNFMAMSLDEAYlnitkhleerqnwpedkrryfikmgssvendnpgkevnklsehersispllfeesp 191
Cdd:PRK03348   86 SRRVFDTLRELSPVVEQLSFDEAF-------------------------------------------------------- 109

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931 192 sdVQPPGdpfqvnfeeqnnpqilqnsvVFGTSAQEVVK---EIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQ 268
Cdd:PRK03348  110 --VEPAE--------------------LAGASAEEVEAfaeRLRARVREETGLPASVGAGSGKQIAKIASGLAKPDGIRV 167

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931 269 ILPNRQavMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELyqqRALlsllfSETSWHYFLHISLGLGSTHLTR----- 343
Cdd:PRK03348  168 VPPGEE--RELLAPLPVRRLWGIGPVTEEKLHRLGIETIGDL---AAL-----SEAEVANLLGATVGPALHRLARgiddr 237

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931 344 ----DGERKSMSVERTF-SEINKAEEQYSLCQELCSELAQDLQKERLKGRTVTIKLKNVNFEVKTRASTVSSVVSTAEEI 418
Cdd:PRK03348  238 pvaeRAEAKQISAESTFaVDLTTRAQLREAIERIAEHAHRRLLKDGRGARTVTVKLRKSDFSTLTRSATLPYATDDAAVL 317

                         410       420       430
                  ....*....|....*....|....*....|..
gi 2086547931 419 FAIAKELLkteIDADFPHPlrLRLMGVRISSF 450
Cdd:PRK03348  318 AATARRLL---LDPDEIGP--IRLVGVGFSGL 344
PolY cd00424
Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases ...
 38-448 1.74e-49

Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Most TLS polymerases are members of the Y-family, including Pol eta, Pol kappa/IV, Pol iota, Rev1, and Pol V, which is found exclusively in bacteria. In eukaryotes, the B-family polymerase Pol zeta also functions as a TLS polymerase. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention.


Pssm-ID: 176453 [Multi-domain]  Cd Length: 343  Bit Score: 177.94  E-value: 1.74e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931  38 VHIDMDAFYAAVEMRDNPELKDKPIAVGSMSMLSTS----NYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSK 113
Cdd:cd00424     1 LHIDFDNFFASVEQLARPELKGRPVVVVPFNSDSTCviacSYEARKYGVKRGMPVREARKMCPNLILVPARLDLYRRLSE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931 114 EVKEILADYDPNFMAMSLDEAYLNITKhleerqnwpedkrryfikmgssvendnpgkevnklsehersispllfeespsd 193
Cdd:cd00424    81 RLLSELEEVAPLVEVASIDELFLDLTG----------------------------------------------------- 107

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931 194 vqppgdpfqvnfeeqnnpqilqnSVVFGTSAQEVVKEIRFRIEQKT-TLTASAGIAPNTMLAKVCSDKNKPNGQYQILPn 272
Cdd:cd00424   108 -----------------------SARLLGLGSEVALRIKRHIAEQLgGITASIGIASNKLLAKLAAKYAKPDGLTILDP- 163

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931 273 rQAVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELY--QQRALLSLLFSETS--WHYFLHislGLGSTHLTRDGERK 348
Cdd:cd00424   164 -EDLPGFLSKLPLTDLPGIGAVTAKRLEAVGINPIGDLLaaSPDALLALWGGVSGerLWYALR---GIDDEPLSPPRPRK 239

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931 349 SMSVERTF-SEINKAEEQYSLCQELCSELAQDLQKERLKGRTVTIKLKNVN------FEVKTRASTVSSVVSTaEEIFAI 421
Cdd:cd00424   240 SFSHERVLpRDSRNAEDARPLLRLLLEKLARRLRRDGRGATRLRLWLRTVDgrwsghADIPSRSAPRPISTED-GELLHA 318

                         410       420
                  ....*....|....*....|....*..
gi 2086547931 422 AKELLKTEIDAdfPHPLRLRLMGVRIS 448
Cdd:cd00424   319 LDKLWRALLDD--KGPRRLRRLGVRLS 343
PRK01810 PRK01810
DNA polymerase IV; Validated
 34-445 2.35e-49

DNA polymerase IV; Validated


Pssm-ID: 179337 [Multi-domain]  Cd Length: 407  Bit Score: 179.46  E-value: 2.35e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931  34 SNTIVHIDMDAFYAAVEMRDNPELKDKPIAV-GSMS----MLSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKY 108
Cdd:PRK01810    4 GRVIFHVDMNSFFASVEIAYDPSLQGKPLAVaGNEKerkgIIVTCSYEARAYGIRTTMPLWEAKRLCPQLIVRRPNFDRY 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931 109 RAVSKEVKEILADYDPNFMAMSLDEAYLNITKHLEerqnwpedkrryfikmgssvendnpgkevnklseherSISPLlfe 188
Cdd:PRK01810   84 REASRQMFQILSEFTPLVQPVSIDEGYLDITDCYA-------------------------------------LGSPL--- 123

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931 189 espsdvqppgdpfqvnfeeqnnpqilqnsvvfgtsaqEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGqYQ 268
Cdd:PRK01810  124 -------------------------------------EIAKMIQQRLLTELQLPCSIGIAPNKFLAKMASDMKKPLG-IT 165

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931 269 ILPNRQaVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELYQ-QRALLSLLFSETswhyflhislGL-------GSTH 340
Cdd:PRK01810  166 VLRKRD-VPEMLWPLPVGEMHGIGEKTAEKLKDIGIQTIGDLAKaDEHILRAKLGIN----------GVrlqrranGIDD 234

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931 341 LTRDGER----KSMSVERTFSEiNKAEEQ--YSLCQELCSELAQDLQKERLKGRTVTIKLKNVNFEVKTRASTVSSVVST 414
Cdd:PRK01810  235 RPVDPEAiyqfKSVGNSTTLSH-DMDEEKelLDVLRRLSKSVSKRLQKKTVVSYNVQIMIRYHDRRTITRSKTLKNPIWE 313

                         410       420       430
                  ....*....|....*....|....*....|.
gi 2086547931 415 AEEIFAIAKELLKTEIDADfphplRLRLMGV 445
Cdd:PRK01810  314 KRDIFQAASRLFKQHWNGD-----PVRLLGV 339
PolY_Rev1 cd01701
DNA polymerase Rev1; Rev1 is a translesion synthesis (TLS) polymerase found in eukaryotes. ...
 15-448 5.11e-48

DNA polymerase Rev1; Rev1 is a translesion synthesis (TLS) polymerase found in eukaryotes. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Rev1 has both structural and enzymatic roles. Structurally, it is believed to interact with other nonclassical polymerases and replication machinery to act as a scaffold. Enzymatically, it catalyzes the specific insertion of dCMP opposite abasic sites. Rev1 interacts with the Rev7 subunit of the B-family TLS polymerase Pol zeta (Rev3/Rev7). Rev1 is known to actively promote the introduction of mutations, potentially making it a significant target for cancer treatment.


Pssm-ID: 176455 [Multi-domain]  Cd Length: 404  Bit Score: 175.58  E-value: 5.11e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931  15 KAQLQvDRFAMELEQSRN----------LSNTIVHIDMDAFYAAVEMRDNPELKDKPIAV----GSMSMLSTSNYHARRF 80
Cdd:cd01701    18 KARLK-DFFRELSNGSKEadpsnsihpdLQRIIMHVDFDCFFVSVSIRNRPDLKGKPVAVchgkGPNSEIASCNYEARSY 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931  81 GVRAAMpgFI--AKRLCPQLIIVPPNFDKYRAVSKEVKEILADYDPNFMAMSLDEAYLNITKHLEERQnwpedkrryfik 158
Cdd:cd01701    97 GIKNGM--WVgqAKKLCPQLVTLPYDFEAYEEVSLTFYEILASYTDNIEAVSCDEALIDITSLLEETY------------ 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931 159 mgssvendnpgkevnklsehersispllfeespsdvqppgdpfqvnfeeqnnpqilqnsvvfgTSAQEVVKEIRFRIEQK 238
Cdd:cd01701   163 ---------------------------------------------------------------ELPEELAEAIRNEIRET 179

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931 239 TTLTASAGIAPNTMLAKVCSDKNKPNGQYQILPnrQAVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELYQQ----R 314
Cdd:cd01701   180 TGCSASVGIGPNILLARLATRKAKPDGQYHLSA--EKVEEFLSQLKVGDLPGVGSSLAEKLVKLFGDTCGGLELRsktkE 257

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931 315 ALLSLLFSETSWHyFLHISLGLGSTHLTRDGERKSMSVertfsEIN------KAEEQYSLCQELCSELAQDLQKERLKGR 388
Cdd:cd01701   258 KLQKVLGPKTGEK-LYDYCRGIDDRPVTGEKERKSVSA-----EINygirftNVDDVEQFLQRLSEELSKRLEESNVTGR 331

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2086547931 389 TVTIKLKN------------------VNFevkTRASTVSSVVSTAEEIFAIAKELLKTeIDADfphPLRLRLMGVRIS 448
Cdd:cd01701   332 QITLKLMKrapgapieppkymghgicDSF---SKSSTLGVATDDSGVIGTEAKKLFRD-LSIP---PEELRGVGIQVT 402
PRK03858 PRK03858
DNA polymerase IV; Validated
 36-460 3.24e-47

DNA polymerase IV; Validated


Pssm-ID: 179663 [Multi-domain]  Cd Length: 396  Bit Score: 172.86  E-value: 3.24e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931  36 TIVHIDMDAFYAAVEMRDNPELKDKPIAVGSMSMLSTSnYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSKEV 115
Cdd:PRK03858    5 SILHADLDSFYASVEQRDDPALRGRPVIVGGGVVLAAS-YEAKAYGVRTAMGGRQARRLCPQAVVVPPRMSAYSRASKAV 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931 116 KEILADYDPNFMAMSLDEAYLNITkhleerqnwpeDKRRyfikmgssvendnpgkevnklsehersispllfeespsdvq 195
Cdd:PRK03858   84 FEVFRDTTPLVEGLSIDEAFLDVG-----------GLRR----------------------------------------- 111

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931 196 ppgdpfqvnfeeqnnpqilqnsvVFGTSAQeVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQILPNRQa 275
Cdd:PRK03858  112 -----------------------ISGTPVQ-IAARLRRRVREEVGLPITVGVARTKFLAKVASQVAKPDGLLVVPPDRE- 166

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931 276 vMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELYQ--QRALLSLLFSETSWHyfLH-ISLGLGSTHLTRDGERKSMSV 352
Cdd:PRK03858  167 -LAFLHPLPVRRLWGVGPVTAAKLRAHGITTVGDVAElpESALVSLLGPAAGRH--LHaLAHNRDPRRVETGRRRRSVGA 243

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931 353 ERTFSEINKAEEQY--SLCQeLCSELAQDLQKERLKGRTVTIKLKNVNFEVKTRASTVSSVVSTAEEIFAIAKELLktei 430
Cdd:PRK03858  244 QRALGRGPNSPAEVdaVVVA-LVDRVARRMRAAGRTGRTVVLRLRFDDFTRATRSHTLPRPTASTATLLAAARDLV---- 318

                         410       420       430
                  ....*....|....*....|....*....|..
gi 2086547931 431 DADFP-HPLR-LRLMGVRISsfpNEEDRKHQQ 460
Cdd:PRK03858  319 AAAAPlIAERgLTLVGFAVS---NLDDDGAQQ 347
IMS pfam00817
impB/mucB/samB family; These proteins are involved in UV protection (Swiss).
 40-259 4.02e-46

impB/mucB/samB family; These proteins are involved in UV protection (Swiss).


Pssm-ID: 425885 [Multi-domain]  Cd Length: 148  Bit Score: 161.59  E-value: 4.02e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931  40 IDMDAFYAAVEMRDNPELKDKPIAVGS---MSMLSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSKEVK 116
Cdd:pfam00817   1 IDMDAFFASVELLRDPELKGKPVAVGGgngRGIVAAASYEARKYGVRSGMPVFEAKKLCPNLIVVPPDLELYRRASRKIF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931 117 EILADY-DPNFMAMSLDEAYLNITKHLEerqnwpedkrryfikmgssvendnpgkevnklsehersisplLFEespsdvq 195
Cdd:pfam00817  81 EILRRFsTPKVEQASIDEAFLDLTGLEK------------------------------------------LFG------- 111

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2086547931 196 ppgdpfqvnfeeqnnpqilqnsvvfgtSAQEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSD 259
Cdd:pfam00817 112 ---------------------------AEEALAKRLRREIAEETGLTCSIGIAPNKLLAKLASD 148
PolY_Pol_eta cd01702
DNA Polymerase eta; Pol eta, also called Rad30A, is a translesion synthesis (TLS) polymerase. ...
 38-452 2.37e-35

DNA Polymerase eta; Pol eta, also called Rad30A, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Unlike other Y-family members, Pol eta can efficiently and accurately replicate DNA past UV-induced lesions. Its activity is initiated by two simultaneous interactions: the PIP box in pol eta interacting with PCNA, and the UBZ (ubiquitin-binding zinc finger) in pol eta interacting with monoubiquitin attached to PCNA. Pol eta is more efficient in copying damaged DNA than undamaged DNA and seems to recognize when a lesion has been passed, facilitating a lesion-dependent dissociation from the DNA.


Pssm-ID: 176456 [Multi-domain]  Cd Length: 359  Bit Score: 137.83  E-value: 2.37e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931  38 VHIDMDAFYAAVEMRDNPELKDKPIAVGSMSMLSTSNYHARRFGVRAAMPGFIAKRLCPQLII--VPP------------ 103
Cdd:cd01702     1 AHIDMDAFFAQVEQVRLGLLRNDPVAVVQWNSIIAVSYAARAFGVTRFMTIDEAKKKCPDLILahVATykkgedeadyhe 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931 104 ---------NFDKYRAVSKEVKEILADYDPNFMAMSLDEAYLNItkhleerqnwpedkrryfikmgssvendnpgkevnk 174
Cdd:cd01702    81 npsparhkvSLDPYRRASRKILNILKRFGDVVEKASIDEAYLDL------------------------------------ 124

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931 175 lsehersispllfeespsdvqppgdpfqvnfeeqnnpqilqnsvvfgtsAQEVVKEIRFRIEQKTTLTASAGIAPNTMLA 254
Cdd:cd01702   125 -------------------------------------------------GSRIVEEIRQQVYDELGYTCSAGIAHNKMLA 155

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931 255 KVCSDKNKPNGQyQILPNRqAVMDFIKDLPIRKVSGI-GKVTEKMLKALGIITCTELYQQRALLSLL---FSET--SWHY 328
Cdd:cd01702   156 KLASGMNKPNAQ-TILRND-AVASFLSSLPITSIRGLgGKLGEEIIDLLGLPTEGDVAGFRSSESDLqehFGEKlgEWLY 233

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931 329 flHISLGLGSTHLTRDGERKSMSVERTFS-EINKAEEQ-YSLCQELCSELAQDLQKER----LKGRTVTIKLKNVNFEVK 402
Cdd:cd01702   234 --NLLRGIDHEPVKPRPLPKSMGSSKNFPgKTALSTEDvQHWLLVLASELNSRLEDDRyennRRPKTLVLSLRQRGDGVR 311

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|
gi 2086547931 403 TRASTVSSVVsTAEEIFAIAKELLKtEIDADFPHPLRLRLMGVRISSFPN 452
Cdd:cd01702   312 RSRSCALPRY-DAQKIVKDAFKLIK-AINEEGLGLAWNYPLTLLSLSFTK 359
PRK03352 PRK03352
DNA polymerase IV; Validated
 37-454 1.21e-34

DNA polymerase IV; Validated


Pssm-ID: 179564 [Multi-domain]  Cd Length: 346  Bit Score: 135.54  E-value: 1.21e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931  37 IVHIDMDAFYAAVEMRDNPELKDKPIAVG-------SMSMLSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYR 109
Cdd:PRK03352    7 VLHVDLDQFIAAVELLRRPELAGLPVIVGgngdptePRKVVTCASYEARAFGVRAGMPLRTAARRCPDAVFLPSDPAAYD 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931 110 AVSKEVKEILADYDPNFMAMSLDEAYLNITkhleerqnwpedkrryfikmgssvendnpgkevnklsehersispllfee 189
Cdd:PRK03352   87 AASEEVMATLRDLGVPVEVWGWDEAFLGVD-------------------------------------------------- 116

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931 190 spsdvqpPGDPFqvnfeeqnnpqilqnsvvfgtsaqEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQI 269
Cdd:PRK03352  117 -------TDDPE------------------------ALAEEIRAAVLERTGLSCSVGIGDNKLRAKIATGFAKPAGVFRL 165

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931 270 lpNRQAVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTEL-YQQRALLSLLFSETSWHYFLHISLGLGSTHLTRDG-ER 347
Cdd:PRK03352  166 --TDANWMAVMGDRPTDALWGVGPKTAKRLAALGITTVADLaAADPAELAATFGPTTGPWLLLLARGGGDTEVSAEPwVP 243

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931 348 KSMSVERTFSE-INKAEEQYSLCQELCSELAQDLQKE-RLKGRtVTIKLKNVNFEVKTRASTVSSVVSTAEEIFAIAKEL 425
Cdd:PRK03352  244 RSRSREVTFPQdLTDRAEVESAVRELARRVLDEVVAEgRPVTR-VAVKVRTATFYTRTKIRKLPEPTTDPDVIEAAALDV 322

                         410       420
                  ....*....|....*....|....*....
gi 2086547931 426 LKtEIDADFPhplrLRLMGVRISSFPNEE 454
Cdd:PRK03352  323 LD-RFELDRP----VRLLGVRLELAMPDE 346
PRK03103 PRK03103
DNA polymerase IV; Reviewed
 37-463 1.72e-33

DNA polymerase IV; Reviewed


Pssm-ID: 235104 [Multi-domain]  Cd Length: 409  Bit Score: 133.59  E-value: 1.72e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931  37 IVHIDMDAFYAAVEMRDNPELKDKPIAVG------SMSMLSTSnYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRA 110
Cdd:PRK03103    5 ILLVDMQSFYASVEKAANPELKGRPVIVSgdperrSGVVLAAC-PLAKAYGVKTAERLWEAQQKCPDLVVVKPRMQRYID 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931 111 VSKEVKEILADYDPNFMAMSLDEAYLNITkhleerqnwpedkrryfikmGSSvendnpgkevnklsehersispLLFees 190
Cdd:PRK03103   84 VSLQITRILEDFTDLVEPFSIDEQFLDVT--------------------GSQ----------------------KLF--- 118

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931 191 psdvqppGDPfqvnfeeqnnpqilqnsvvfgtsaQEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSD---KNKPNGQY 267
Cdd:PRK03103  119 -------GSP------------------------LEIAQKIQQRIMRETGVYARVGIGPNKLLAKMACDnfaKKNPDGLF 167

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931 268 QIlpNRQAVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELyqqrALLSLLFSETSW----HYFLHISLGLGSTHLTR 343
Cdd:PRK03103  168 TL--DKEDVPADLWPLPVRKLFGVGSRMEKHLRRMGIRTIGQL----ANTPLERLKKRWgingEVLWRTANGIDYSPVTP 241

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931 344 DG--ERKSMSVERTF-SEINKAEEQYSLCQELCSELAQDLQKERLKGRTVTIKLKNVNFEVKT---RASTVSSVVSTAEE 417
Cdd:PRK03103  242 HSldRQKAIGHQMTLpRDYRGFEEIKVVLLELCEEVCRRARAKGYMGRTVSVSLRGADFDWPTgfsRQMTLPEPTNLAME 321

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2086547931 418 IFAIAKELLKTEIDAdfphpLRLRLMGVRISSF-PNEE------DRKHQQRSI 463
Cdd:PRK03103  322 VYEAACKLFHRHWDG-----KPVRRVGVTLSNLvSDDVwqlslfGDRERKRSL 369
PolY_Pol_iota cd01703
DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. ...
 38-445 2.35e-32

DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol iota is thought to be one of the least efficient polymerases, particularly when opposite pyrimidines; it can incorporate the correct nucleotide opposite a purine much more efficiently than opposite a pyrimidine, and prefers to insert guanosine instead of adenosine opposite thymidine. Pol iota is believed to use Hoogsteen rather than Watson-Crick base pairing, which may explain the varying efficiency for different template nucleotides.


Pssm-ID: 176457 [Multi-domain]  Cd Length: 379  Bit Score: 129.51  E-value: 2.35e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931  38 VHIDMDAFYAAVEMRDNPELKDKPIAVGSMSMLSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVP-PNFDKYRAVSKEVK 116
Cdd:cd01703     1 IHLDLDCFYAQVEEIRDPSLKSKPLGIQQKYIVVTCNYEARRLGVKKLMSIKDAKEICPDLVLVNgEDLTPFRDMSKKVY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931 117 EILADYDPNFMA--MSLDEAYLNITkhleerqnwpeDKRryfikmgssvendnpgkevnklsehersispLLFeespsdv 194
Cdd:cd01703    81 RLLRSYSWNDRVerLGFDENFMDVT-----------EMR-------------------------------LLV------- 111

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931 195 qppgdpfqvnfeeqnnpqilqnsvvfgtsAQEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQILP-NR 273
Cdd:cd01703   112 -----------------------------ASHIAYEMRERIENELGLTCCAGIASNKLLAKLVGSVNKPNQQTTLLPpSC 162

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931 274 QAVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELyQQRALLSLLFSETSWHYFLHISLGLG-----STHLT-----R 343
Cdd:cd01703   163 ADLMDFMDLHDLRKIPGIGYKTAAKLEAHGISSVRDL-QEFSNRNRQTVGAAPSLLELLLMVKEfgegiGQRIWkllfgR 241

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931 344 DGER--------KSMSVERTF-----SEINKAEEQYS---------LCQELCSELAQDLQKERLKGRTV---TIKLKNVN 398
Cdd:cd01703   242 DTSPvkpasdfpQQISIEDSYkkcslEEIREARNKIEellasllerMKQDLQEVKAGDGRRPHTLRLTLrryTSTKKHYN 321

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2086547931 399 FEVKTrASTVSSVVST--------AEEIFAIAKELLKTEIDADFPHPLRLRLMGV 445
Cdd:cd01703   322 RESKQ-APIPSHVFQKltggneiaARPIEKILMRLFRELVPPKNVKGFNLTLLNV 375
PRK01216 PRK01216
DNA polymerase IV; Validated
 37-304 9.49e-32

DNA polymerase IV; Validated


Pssm-ID: 179251 [Multi-domain]  Cd Length: 351  Bit Score: 127.21  E-value: 9.49e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931  37 IVHIDMDAFYAAVEMRDNPELKDKPIAVGSMS-------MLSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYR 109
Cdd:PRK01216    3 ILFVDFDYFFAQVEEVLNPSLKGKPVVVCVYSgrfedsgAVATANYEARKLGIKAGMPIVEAKKILPNAVYLPMRKEVYQ 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931 110 AVSKEVKEILADYDPNFMAMSLDEAYLNITKHLEerqnwpedkrryfikmgssvendnpgkevnklsehersispllfee 189
Cdd:PRK01216   83 QVSNRIMKLLREYSEKIEIASIDEAYLDISDKVK---------------------------------------------- 116

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931 190 spsdvqppgdpfqvNFEEqnnpqilqnsvvfgtsAQEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQI 269
Cdd:PRK01216  117 --------------NYQD----------------AYNLGLEIKNKILEKEKITVTVGISKNKVFAKIAADMAKPNGIKVI 166

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 2086547931 270 LPnrQAVMDFIKDLPIRKVSGIGKVTEKMLKALGI 304
Cdd:PRK01216  167 DD--EEVKRFINELDIADIPGIGDITAEKLKKLGV 199
PolY_Pol_V_umuC cd01700
umuC subunit of DNA Polymerase V; umuC subunit of Pol V. Pol V is a bacterial translesion ...
 40-392 1.81e-26

umuC subunit of DNA Polymerase V; umuC subunit of Pol V. Pol V is a bacterial translesion synthesis (TLS) polymerase that consists of the heterotrimer of one umuC and two umuD subunits. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol V, RecA, single stranded DNA-binding protein, beta sliding clamp, and gamma clamp loading complex are responsible for inducing the SOS response in bacteria to repair UV-induced DNA damage.


Pssm-ID: 176454 [Multi-domain]  Cd Length: 344  Bit Score: 111.49  E-value: 1.81e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931  40 IDMDAFYAAVEMRDNPELKDKPIAVgsmsmLSTS-------NYHARRFGVRAAMPGFIAKRLCPQL--IIVPPNFDKYRA 110
Cdd:cd01700     3 VDCNSFYASCERVFRPLLLGRPLVV-----LSNNdgcviarSPEAKALGIKMGSPYFKVPDLLERHgvAVFSSNYALYGD 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931 111 VSKEVKEILADYDPNFMAMSLDEAYLNITkhleerqnwpedkrryfikmgssvendnpgkevnklsehersispllfees 190
Cdd:cd01700    78 MSRRIMSILERFSPDVEVYSIDESFLDLT--------------------------------------------------- 106

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931 191 psDVQPPGDPfqvnfeeqnnpqilqnsvvfgtsaQEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSD----KNKPNGQ 266
Cdd:cd01700   107 --GSLRFGDL------------------------EELARKIRRRILQETGIPVTVGIGPTKTLAKLANDlakkKNPYGGV 160

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931 267 YQIL--PNRQAVMdfiKDLPIRKVSGIGKVTEKMLKALGIIT-----CTELYQQRALLSLLFSETSWHyfLH-IS-LGLG 337
Cdd:cd01700   161 VDLTdeEVRDKLL---KILPVGDVWGIGRRTAKKLNAMGIHTagdlaQADPDLLRKKFGVVGERLVRE--LNgIDcLPLE 235

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2086547931 338 STHltrdGERKSMSVERTFSE-INKAEEQYSLCQELCSELAQDLQKERLKGRTVTI 392
Cdd:cd01700   236 EYP----PPKKSIGSSRSFGRdVTDLDELKQALAEYAERAAEKLRRQKSVARTISV 287
IMS_C pfam11799
impB/mucB/samB family C-terminal domain; These proteins are involved in UV protection (Swiss).
 347-454 8.71e-22

impB/mucB/samB family C-terminal domain; These proteins are involved in UV protection (Swiss).


Pssm-ID: 463354 [Multi-domain]  Cd Length: 104  Bit Score: 90.70  E-value: 8.71e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931 347 RKSMSVERTFSE-INKAEEQYSLCQELCSELAQDLQKERLKGRTVTIKLKNVNFEVKTRASTVSSVVSTAEEIFAIAKEL 425
Cdd:pfam11799   1 RKSIGAERTFGRdLTDLEELREALLELAEELAERLRRQGLVARTVTVKIRYSDFRTITRSVTLPSPTDDTDEIYRAALRL 80

                          90       100
                  ....*....|....*....|....*....
gi 2086547931 426 LKteidaDFPHPLRLRLMGVRISSFPNEE 454
Cdd:pfam11799  81 LR-----RLYRGRPVRLLGVSLSNLVPEG 104
IMS_HHH pfam11798
IMS family HHH motif; These proteins are involved in UV protection, eg.
 273-304 8.32e-07

IMS family HHH motif; These proteins are involved in UV protection, eg.


Pssm-ID: 432081 [Multi-domain]  Cd Length: 32  Bit Score: 45.85  E-value: 8.32e-07
                          10        20        30
                  ....*....|....*....|....*....|..
gi 2086547931 273 RQAVMDFIKDLPIRKVSGIGKVTEKMLKALGI 304
Cdd:pfam11798   1 PDDVPEFLWPLPISKIPGIGKKLAEKLKALGI 32
umuC PRK03609
translesion error-prone DNA polymerase V subunit UmuC;
39-313 5.51e-05

translesion error-prone DNA polymerase V subunit UmuC;


Pssm-ID: 179607 [Multi-domain]  Cd Length: 422  Bit Score: 46.30  E-value: 5.51e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931  39 HIDMDAFYAAVEMRDNPELKDKPIAVGSMS--MLSTSNYHARRFGVRAAMPGFIAK--RLCPQLIIVPPNFDKYRAVSKE 114
Cdd:PRK03609    4 LCDVNSFYASCETVFRPDLRGKPVVVLSNNdgCVIARSAEAKALGIKMGDPWFKQKdlFRRCGVVCFSSNYELYADMSNR 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931 115 VKEILADYDPNFMAMSLDEAYLNITkhleerqnwpedkrryfikmgsSVENdnpgkevnklsehersispllfeespsdv 194
Cdd:PRK03609   84 VMSTLEELSPRVEIYSIDEAFCDLT----------------------GVRN----------------------------- 112

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931 195 qppgdpfQVNFEEqnnpqilqnsvvFGtsaqevvKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKP----NGQYQIL 270
Cdd:PRK03609  113 -------CRDLTD------------FG-------REIRATVLQRTHLTVGVGIAQTKTLAKLANHAAKKwqrqTGGVVDL 166

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 2086547931 271 PNRQAVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELYQQ 313
Cdd:PRK03609  167 SNLERQRKLLSLQPVEEVWGVGRRISKKLNAMGIKTALDLADT 209
ZnF_Rad18 smart00734
Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative ...
 555-581 8.81e-05

Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative DNA repair. This zinc finger is likely to bind nucleic-acids.


Pssm-ID: 128973 [Multi-domain]  Cd Length: 24  Bit Score: 39.90  E-value: 8.81e-05
                           10        20
                   ....*....|....*....|....*..
gi 2086547931  555 ILTCPVCFRAQgciSLEALNKHVDECL 581
Cdd:smart00734   1 LVQCPVCFREV---PENLINSHLDSCL 24
ZnF_Rad18 smart00734
Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative ...
 710-736 2.35e-04

Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative DNA repair. This zinc finger is likely to bind nucleic-acids.


Pssm-ID: 128973 [Multi-domain]  Cd Length: 24  Bit Score: 38.74  E-value: 2.35e-04
                           10        20
                   ....*....|....*....|....*..
gi 2086547931  710 ALVCPVCNVEQKtsdLTLFNVHVDVCL 736
Cdd:smart00734   1 LVQCPVCFREVP---ENLINSHLDSCL 24
PolY_like cd03468
DNA Polymerase Y-family; Y-family DNA polymerases are a specialized subset of polymerases that ...
 231-427 3.85e-04

DNA Polymerase Y-family; Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention.


Pssm-ID: 176458 [Multi-domain]  Cd Length: 335  Bit Score: 43.52  E-value: 3.85e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931 231 IRFRIEQKTT-LTASAGIAPNTMLAKVCSDKNKPNGQYQIlPNRQAVMDFIKDLPIRkVSGIGKVTEKMLKALGIIT--- 306
Cdd:cd03468   119 ASLRAALATLgLSARAGIADTPGAAWLLARAGGGRGVLRR-EALAAALVLLAPLPVA-ALRLPPETVELLARLGLRTlgd 196

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2086547931 307 CTELYqqRALLSLLFSE--TSWHYFLhislgLGSTHLTRDG----ERKSMSVERTFsEINKAEEQYSLCQELCSELAQDL 380
Cdd:cd03468   197 LAALP--RAELARRFGLalLLRLDQA-----YGRDPEPLLFspppPAFDFRLELQL-EEPIARGLLFPLRRLLEQLCAFL 268

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 2086547931 381 QKERLKGRTVTIKLKNVNFEVKTRASTVSSVVSTAEEIFAIAKELLK 427
Cdd:cd03468   269 ALRGLGARRLSLTLFREDGRVTRVLVGLARPSRDDLPLLRLLRERLE 315
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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