NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2154713088|ref|NP_001384558|]
View 

transient receptor potential cation channel subfamily M member 8 isoform 17 [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
LSDAT_euk super family cl39032
SLOG in TRPM; Family in the SLOG superfamily, found in several eukaryotic channels including ...
 39-150 2.80e-44

SLOG in TRPM; Family in the SLOG superfamily, found in several eukaryotic channels including diverse ciliate channels and the TRPM class of animal ion channels. Positioned near the N-terminus of all TRPM channels, it is predicted to play a regulatory role for the channel in potentially recognizing a universal nucleotide or nucleotide-derived ligand.


The actual alignment was detected with superfamily member pfam18139:

Pssm-ID: 476852  Cd Length: 266  Bit Score: 146.57  E-value: 2.80e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154713088  39 KYIRLSCDTDAEILYELLTQHWHLKTPNLVISVTGGAKNFALKPRMRKIFSR-LIYIAQSKGAWILTGGTHYGLMKYIGE 117
Cdd:pfam18139   2 KYIRLSFDTDPEDLLHLMEKEWQLELPKLVISVHGGATNFELQPKLKRVFRKgLLKAAKTTGAWIITGGTNTGVMRHVGD 81

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2154713088 118 VVRDNTISRSSeeNIVAIGIAAWGMVSNRDTLI 150
Cdd:pfam18139  82 ALKDLGSQSRR--KIVTIGIAPWGIIKNREDLI 112
 
Name Accession Description Interval E-value
LSDAT_euk pfam18139
SLOG in TRPM; Family in the SLOG superfamily, found in several eukaryotic channels including ...
 39-150 2.80e-44

SLOG in TRPM; Family in the SLOG superfamily, found in several eukaryotic channels including diverse ciliate channels and the TRPM class of animal ion channels. Positioned near the N-terminus of all TRPM channels, it is predicted to play a regulatory role for the channel in potentially recognizing a universal nucleotide or nucleotide-derived ligand.


Pssm-ID: 465665  Cd Length: 266  Bit Score: 146.57  E-value: 2.80e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154713088  39 KYIRLSCDTDAEILYELLTQHWHLKTPNLVISVTGGAKNFALKPRMRKIFSR-LIYIAQSKGAWILTGGTHYGLMKYIGE 117
Cdd:pfam18139   2 KYIRLSFDTDPEDLLHLMEKEWQLELPKLVISVHGGATNFELQPKLKRVFRKgLLKAAKTTGAWIITGGTNTGVMRHVGD 81

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2154713088 118 VVRDNTISRSSeeNIVAIGIAAWGMVSNRDTLI 150
Cdd:pfam18139  82 ALKDLGSQSRR--KIVTIGIAPWGIIKNREDLI 112
 
Name Accession Description Interval E-value
LSDAT_euk pfam18139
SLOG in TRPM; Family in the SLOG superfamily, found in several eukaryotic channels including ...
 39-150 2.80e-44

SLOG in TRPM; Family in the SLOG superfamily, found in several eukaryotic channels including diverse ciliate channels and the TRPM class of animal ion channels. Positioned near the N-terminus of all TRPM channels, it is predicted to play a regulatory role for the channel in potentially recognizing a universal nucleotide or nucleotide-derived ligand.


Pssm-ID: 465665  Cd Length: 266  Bit Score: 146.57  E-value: 2.80e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154713088  39 KYIRLSCDTDAEILYELLTQHWHLKTPNLVISVTGGAKNFALKPRMRKIFSR-LIYIAQSKGAWILTGGTHYGLMKYIGE 117
Cdd:pfam18139   2 KYIRLSFDTDPEDLLHLMEKEWQLELPKLVISVHGGATNFELQPKLKRVFRKgLLKAAKTTGAWIITGGTNTGVMRHVGD 81

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2154713088 118 VVRDNTISRSSeeNIVAIGIAAWGMVSNRDTLI 150
Cdd:pfam18139  82 ALKDLGSQSRR--KIVTIGIAPWGIIKNREDLI 112
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH