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Conserved domains on  [gi|2164644499|ref|NP_001385211|]
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TIMELESS-interacting protein isoform 1 [Homo sapiens]

Protein Classification

Chromosome segregation in meiosis protein 3( domain architecture ID 10546341)

Chromosome segregation in meiosis protein 3 (Csm3) is part of Tof1-Csm3-Mrc1 in S. cerevisiae, functions analogously to Swi3, part of the Swi1-Swi3 complex in S. pombe and TIMELESS-TIPIN with Claspin in mammalian cells for replication fork pausing complexes which are essential for maintaining the coupling between the DNA synthesis machinery of the replisome and the MCM helicase. This coordination ensures that DNA replication proceeds efficiently, even under conditions that may cause the fork to pause or slow, helping to stabilize the replication process and prevent genomic instability.

Gene Ontology:  GO:0000076|GO:0003677
PubMed:  15367656|17116885|14742714

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Swi3 pfam07962
Replication Fork Protection Component Swi3; Replication fork pausing is required to initiate a ...
 66-148 1.72e-39

Replication Fork Protection Component Swi3; Replication fork pausing is required to initiate a recombination events. More specifically, Swi1 is required for recombination near the mat1 locus. Swi3 has been found to co-purify with Swi1 Swi3, together with Swi1, define a fork protection complex that coordinates leading- and lagging-strand synthesis and stabilizes stalled replication forks. The Swi1-Swi3 complex is required for accurate replication, fork protection and replication checkpoint signalling


:

Pssm-ID: 462324  Cd Length: 83  Bit Score: 133.39  E-value: 1.72e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2164644499  66 KLDAQRLISERGLPALRHVFDKAKFKGKGHEAEDLKMLIRHMEHWAHRLFPKLQFEDFIDRVEYLGSKKEVQTCLKRIRL 145
Cdd:pfam07962   1 KLDEERLLSPKGLPYLRKNFKKFKFKGKGHEYEDLGRLLQFYQLWAHDLFPKAKFKDFIERVEKLGKKKRVRTYRRELRD 80


                  ...
gi 2164644499 146 DLP 148
Cdd:pfam07962  81 EEK 83
 
Name Accession Description Interval E-value
Swi3 pfam07962
Replication Fork Protection Component Swi3; Replication fork pausing is required to initiate a ...
 66-148 1.72e-39

Replication Fork Protection Component Swi3; Replication fork pausing is required to initiate a recombination events. More specifically, Swi1 is required for recombination near the mat1 locus. Swi3 has been found to co-purify with Swi1 Swi3, together with Swi1, define a fork protection complex that coordinates leading- and lagging-strand synthesis and stabilizes stalled replication forks. The Swi1-Swi3 complex is required for accurate replication, fork protection and replication checkpoint signalling


Pssm-ID: 462324  Cd Length: 83  Bit Score: 133.39  E-value: 1.72e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2164644499  66 KLDAQRLISERGLPALRHVFDKAKFKGKGHEAEDLKMLIRHMEHWAHRLFPKLQFEDFIDRVEYLGSKKEVQTCLKRIRL 145
Cdd:pfam07962   1 KLDEERLLSPKGLPYLRKNFKKFKFKGKGHEYEDLGRLLQFYQLWAHDLFPKAKFKDFIERVEKLGKKKRVRTYRRELRD 80


                  ...
gi 2164644499 146 DLP 148
Cdd:pfam07962  81 EEK 83
 
Name Accession Description Interval E-value
Swi3 pfam07962
Replication Fork Protection Component Swi3; Replication fork pausing is required to initiate a ...
 66-148 1.72e-39

Replication Fork Protection Component Swi3; Replication fork pausing is required to initiate a recombination events. More specifically, Swi1 is required for recombination near the mat1 locus. Swi3 has been found to co-purify with Swi1 Swi3, together with Swi1, define a fork protection complex that coordinates leading- and lagging-strand synthesis and stabilizes stalled replication forks. The Swi1-Swi3 complex is required for accurate replication, fork protection and replication checkpoint signalling


Pssm-ID: 462324  Cd Length: 83  Bit Score: 133.39  E-value: 1.72e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2164644499  66 KLDAQRLISERGLPALRHVFDKAKFKGKGHEAEDLKMLIRHMEHWAHRLFPKLQFEDFIDRVEYLGSKKEVQTCLKRIRL 145
Cdd:pfam07962   1 KLDEERLLSPKGLPYLRKNFKKFKFKGKGHEYEDLGRLLQFYQLWAHDLFPKAKFKDFIERVEKLGKKKRVRTYRRELRD 80


                  ...
gi 2164644499 146 DLP 148
Cdd:pfam07962  81 EEK 83
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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