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Conserved domains on  [gi|289577080|ref|NP_001409|]
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eukaryotic translation initiation factor 4 gamma 2 isoform 1 [Homo sapiens]

Protein Classification

eukaryotic translation initiation factor 4 gamma 2( domain architecture ID 13683362)

eukaryotic translation initiation factor 4 gamma 2 (EIF4G2) appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
W2_eIF4G1_like cd11559
C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar ...
740-876 8.40e-51

C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins; eIF4G1 is a component of the multi-subunit eukaryotic translation initiation factor 4F, which facilitates recruitment of the mRNA to the ribosome, a rate-limiting step during translation initiation. This C-terminal domain, whose structure resembles that of a set of concatenated HEAT repeats, has been associated with binding to/recruiting the kinase Mnk1, which phosphorylates eIF4E.


:

Pssm-ID: 211397  Cd Length: 134  Bit Score: 174.78  E-value: 8.40e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577080 740 QIKLDPSPQTIYKWIKDNISPKLHVDKGFVNILMTSFLQYISSEvnppsdetdsssapsKEQLEQEKQLLLSFKPVMQKF 819
Cdd:cd11559   13 LLQEDPNPDELYKWIKENVSPELYASPGFVRALMTAVLKYAIEE---------------KSLPEKEKALLEKYAPLLQKY 77
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 289577080 820 LHDHVDLQVSALYALQVHCYNSNFPKGMLLRFFVHFYDMEIIEEEAFLAWKEDITQE 876
Cdd:cd11559   78 LDDDEQLQLQALYALQALVHTLEFPKGLLLRFFDALYDEDVIEEEAFLKWKEDVDPA 134
MIF4G pfam02854
MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). ...
78-308 2.47e-50

MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA.


:

Pssm-ID: 397130  Cd Length: 203  Bit Score: 176.01  E-value: 2.47e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577080   78 FRKVRGILNKLTPEKFDKLCLELLNVGVESKLILKGVILLIVDKALEEPKYSSLYAQLCLRLAedapnfdgpaaegqpgQ 157
Cdd:pfam02854   1 LKKVKGILNKLSPENFEKLIKELLKLIMSDPELLKYLIELIFEKAVEEPNFIPAYARLCSGLN----------------L 64
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577080  158 KQSTTFRRLLISKLQDEFENRtrnvdvydkrenpllPEEEEQRAIAKIKMLGNIKFIGELGKLDLIHESILHKCIKTLLE 237
Cdd:pfam02854  65 RNPTDFGIHLLNRLQEEFEKR---------------FELEENEQGNRRRRLGLVRFLGELYKFGLLTEKILFECLKELLS 129
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 289577080  238 KKKRVQLKDMGEDLECLCQIMRTVGPRLDHERAKSLMDQYFARMCSLMLSK---ELPARIRFLLQDTVELREHH 308
Cdd:pfam02854 130 SLTKEDLKRDLFNLECLLTLLTTIGKLLENEKLPKLMDQFLDEIQKYVLSKddpKLSSRLRFMLQDLIELRKNK 203
MA3 smart00544
Domain in DAP-5, eIF4G, MA-3 and other proteins; Highly alpha-helical. May contain repeats and ...
544-657 2.87e-28

Domain in DAP-5, eIF4G, MA-3 and other proteins; Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains Ponting (TIBS) "Novel eIF4G domain homologues" in press


:

Pssm-ID: 214714  Cd Length: 113  Bit Score: 109.64  E-value: 2.87e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577080   544 LLKLTETVVTEYLNSGNANEAVNGVREMRAPkHFLPEMLSKVIILSLDRSDEDKEKASSLISLLKQEGIATSDNFMQAFL 623
Cdd:smart00544   1 LKKKIFLIIEEYLSSGDTDEAVHCLLELKLP-EQHHEVVKVLLTCALEEKRTYREMYSVLLSRLCQANVISTKQFEKGFW 79
                           90       100       110
                   ....*....|....*....|....*....|....
gi 289577080   624 NVLDQCPKLEVDIPLVKSYLAQFAARAIISELVS 657
Cdd:smart00544  80 RLLEDIEDLELDIPNAWRNLAEFVARLISDGILP 113
PRK12757 super family cl36177
cell division protein FtsN; Provisional
436-543 2.82e-04

cell division protein FtsN; Provisional


The actual alignment was detected with superfamily member PRK12757:

Pssm-ID: 237191 [Multi-domain]  Cd Length: 256  Bit Score: 43.49  E-value: 2.82e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577080 436 SQLYHNQSQgLLSQLQGqskDM--PPRfskkgQLNA---DEISLRPAQSFLMNKNQVPKLQPQITMIPPS-AQPPRTQTP 509
Cdd:PRK12757  78 TQLTDEQRQ-LLEQMQA---DMrqQPT-----QLSEvpyNEQTPQVPRSTVQIQQQAQQQQPPATTAQPQpVTPPRQTTA 148
                         90       100       110
                 ....*....|....*....|....*....|....
gi 289577080 510 PlgQTPQLGLKTNPPliQEKPAKTSKKPPPSKEE 543
Cdd:PRK12757 149 P--VQPQTPAPVRTQ--PAAPVTQAVEAPKVEAE 178
 
Name Accession Description Interval E-value
W2_eIF4G1_like cd11559
C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar ...
740-876 8.40e-51

C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins; eIF4G1 is a component of the multi-subunit eukaryotic translation initiation factor 4F, which facilitates recruitment of the mRNA to the ribosome, a rate-limiting step during translation initiation. This C-terminal domain, whose structure resembles that of a set of concatenated HEAT repeats, has been associated with binding to/recruiting the kinase Mnk1, which phosphorylates eIF4E.


Pssm-ID: 211397  Cd Length: 134  Bit Score: 174.78  E-value: 8.40e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577080 740 QIKLDPSPQTIYKWIKDNISPKLHVDKGFVNILMTSFLQYISSEvnppsdetdsssapsKEQLEQEKQLLLSFKPVMQKF 819
Cdd:cd11559   13 LLQEDPNPDELYKWIKENVSPELYASPGFVRALMTAVLKYAIEE---------------KSLPEKEKALLEKYAPLLQKY 77
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 289577080 820 LHDHVDLQVSALYALQVHCYNSNFPKGMLLRFFVHFYDMEIIEEEAFLAWKEDITQE 876
Cdd:cd11559   78 LDDDEQLQLQALYALQALVHTLEFPKGLLLRFFDALYDEDVIEEEAFLKWKEDVDPA 134
MIF4G pfam02854
MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). ...
78-308 2.47e-50

MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA.


Pssm-ID: 397130  Cd Length: 203  Bit Score: 176.01  E-value: 2.47e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577080   78 FRKVRGILNKLTPEKFDKLCLELLNVGVESKLILKGVILLIVDKALEEPKYSSLYAQLCLRLAedapnfdgpaaegqpgQ 157
Cdd:pfam02854   1 LKKVKGILNKLSPENFEKLIKELLKLIMSDPELLKYLIELIFEKAVEEPNFIPAYARLCSGLN----------------L 64
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577080  158 KQSTTFRRLLISKLQDEFENRtrnvdvydkrenpllPEEEEQRAIAKIKMLGNIKFIGELGKLDLIHESILHKCIKTLLE 237
Cdd:pfam02854  65 RNPTDFGIHLLNRLQEEFEKR---------------FELEENEQGNRRRRLGLVRFLGELYKFGLLTEKILFECLKELLS 129
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 289577080  238 KKKRVQLKDMGEDLECLCQIMRTVGPRLDHERAKSLMDQYFARMCSLMLSK---ELPARIRFLLQDTVELREHH 308
Cdd:pfam02854 130 SLTKEDLKRDLFNLECLLTLLTTIGKLLENEKLPKLMDQFLDEIQKYVLSKddpKLSSRLRFMLQDLIELRKNK 203
MIF4G smart00543
Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The ...
79-308 1.49e-43

Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA. Ponting (TiBS) "Novel eIF4G domain homologues (in press)


Pssm-ID: 214713  Cd Length: 200  Bit Score: 156.75  E-value: 1.49e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577080    79 RKVRGILNKLTPEKFDKLCLELLNVGVESKLILKGVILLIVDKALEEPKYSSLYAQLCLRLAEDAPNFdgpaaegqpgqk 158
Cdd:smart00543   2 KKVKGLINKLSPSNFESIIKELLKLNNSDKNLRKYILELIFEKAVEEPNFIPAYARLCALLNAKNPDF------------ 69
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577080   159 qsttfRRLLISKLQDEFENRtrnvdvydkrenpllpeEEEQRAIAKIKMLGNIKFIGELGKLDLIHESILHKCIKTLLEK 238
Cdd:smart00543  70 -----GSLLLERLQEEFEKG-----------------LESEEESDKQRRLGLVRFLGELYNFQVLTSKIILELLKELLND 127
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 289577080   239 KKRVQLKDMGEDLECLCQIMRTVGPRLDHERAKSLMDQYFARMCSLMLSK---ELPARIRFLLQDTVELREHH 308
Cdd:smart00543 128 LTKLDPPRSDFSVECLLSLLPTCGKDLEREKSPKLLDEILERLQDYLLKKdktELSSRLRFMLELLIELRKNK 200
MA3 smart00544
Domain in DAP-5, eIF4G, MA-3 and other proteins; Highly alpha-helical. May contain repeats and ...
544-657 2.87e-28

Domain in DAP-5, eIF4G, MA-3 and other proteins; Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains Ponting (TIBS) "Novel eIF4G domain homologues" in press


Pssm-ID: 214714  Cd Length: 113  Bit Score: 109.64  E-value: 2.87e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577080   544 LLKLTETVVTEYLNSGNANEAVNGVREMRAPkHFLPEMLSKVIILSLDRSDEDKEKASSLISLLKQEGIATSDNFMQAFL 623
Cdd:smart00544   1 LKKKIFLIIEEYLSSGDTDEAVHCLLELKLP-EQHHEVVKVLLTCALEEKRTYREMYSVLLSRLCQANVISTKQFEKGFW 79
                           90       100       110
                   ....*....|....*....|....*....|....
gi 289577080   624 NVLDQCPKLEVDIPLVKSYLAQFAARAIISELVS 657
Cdd:smart00544  80 RLLEDIEDLELDIPNAWRNLAEFVARLISDGILP 113
eIF5C smart00515
Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5;
814-894 2.45e-24

Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5;


Pssm-ID: 214705  Cd Length: 83  Bit Score: 97.36  E-value: 2.45e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577080   814 PVMQKFLHDHVDLQVSALYALQVHCYNSNFPKGMLLRFFVHFYDMEIIEEEAFLAWKEDITQEfPGKGKALFQVNQWLTW 893
Cdd:smart00515   1 GPLLKFLAKDEEEQLELLYAIEEFCVELEKLGKLLPKILKSLYDADILEEEAILKWYEKAVSA-EGKKKVRKNAKPFVTW 79

                   .
gi 289577080   894 L 894
Cdd:smart00515  80 L 80
W2 pfam02020
eIF4-gamma/eIF5/eIF2-epsilon; This domain of unknown function is found at the C-terminus of ...
827-895 7.92e-20

eIF4-gamma/eIF5/eIF2-epsilon; This domain of unknown function is found at the C-terminus of several translation initiation factors.


Pssm-ID: 460415  Cd Length: 76  Bit Score: 84.12  E-value: 7.92e-20
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 289577080  827 QVSALYALQVHCYNSNFPKGMLLRFFVHFYDMEIIEEEAFLAWKEDITQEFPGKGKALFQVNQWLTWLE 895
Cdd:pfam02020   1 QVDLLLALQEFCAKLEELLKLLLKILKALYDLDIVEEEAILKWWEDVSSAEKGMKKVRKQAKPFVEWLE 69
MA3 pfam02847
MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain ...
546-654 3.06e-15

MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains.


Pssm-ID: 397128  Cd Length: 113  Bit Score: 72.69  E-value: 3.06e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577080  546 KLTETVVTEYLNSGNANEAVNGVREMRAPkHFLPEMLSKVIILSLDRSDEDKEKASSLISLLKQEGIATSDNFMQAFLNV 625
Cdd:pfam02847   3 RKIFLILEEYLSSGDYDEAARCLLKLGLP-SQHHEVVKVLIECALEESKTYREFYGLLLERLCEFNLISTKQFEKGFWRV 81
                          90       100
                  ....*....|....*....|....*....
gi 289577080  626 LDQCPKLEVDIPLVKSYLAQFAARAIISE 654
Cdd:pfam02847  82 LEDLEDLELDIPNAWRNLAEFVARLISDD 110
PRK12757 PRK12757
cell division protein FtsN; Provisional
436-543 2.82e-04

cell division protein FtsN; Provisional


Pssm-ID: 237191 [Multi-domain]  Cd Length: 256  Bit Score: 43.49  E-value: 2.82e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577080 436 SQLYHNQSQgLLSQLQGqskDM--PPRfskkgQLNA---DEISLRPAQSFLMNKNQVPKLQPQITMIPPS-AQPPRTQTP 509
Cdd:PRK12757  78 TQLTDEQRQ-LLEQMQA---DMrqQPT-----QLSEvpyNEQTPQVPRSTVQIQQQAQQQQPPATTAQPQpVTPPRQTTA 148
                         90       100       110
                 ....*....|....*....|....*....|....
gi 289577080 510 PlgQTPQLGLKTNPPliQEKPAKTSKKPPPSKEE 543
Cdd:PRK12757 149 P--VQPQTPAPVRTQ--PAAPVTQAVEAPKVEAE 178
Med15 pfam09606
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of ...
357-541 3.25e-03

ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development.


Pssm-ID: 312941 [Multi-domain]  Cd Length: 732  Bit Score: 41.15  E-value: 3.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577080  357 MPPRMKMDRDPLGGLADMFGQMPGsgiGTGPGVIQDRFSPTMGRHRSNQLFNGHGGHIMPP-------TQSQFGEMGGKF 429
Cdd:pfam09606 246 QQPQQQGQQSQLGMGINQMQQMPQ---GVGGGAGQGGPGQPMGPPGQQPGAMPNVMSIGDQnnyqqqqTRQQQQQQGGNH 322
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577080  430 MKSQGLSQLYHNQSQGLLSQLQGQSKDMPPRFSKKGQLNADeiSLRPAQSFLMNKNQVPKLQ-------PQITMIPPSAQ 502
Cdd:pfam09606 323 PAAHQQQMNQSVGQGGQVVALGGLNHLETWNPGNFGGLGAN--PMQRGQPGMMSSPSPVPGQqvrqvtpNQFMRQSPQPS 400
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 289577080  503 PPRTQTPPL--GQTPQLGLKTNPPLIQEKPAKTSKKPPPSK 541
Cdd:pfam09606 401 VPSPQGPGSqpPQSHPGGMIPSPALIPSPSPQMSQQPAQQR 441
 
Name Accession Description Interval E-value
W2_eIF4G1_like cd11559
C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar ...
740-876 8.40e-51

C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins; eIF4G1 is a component of the multi-subunit eukaryotic translation initiation factor 4F, which facilitates recruitment of the mRNA to the ribosome, a rate-limiting step during translation initiation. This C-terminal domain, whose structure resembles that of a set of concatenated HEAT repeats, has been associated with binding to/recruiting the kinase Mnk1, which phosphorylates eIF4E.


Pssm-ID: 211397  Cd Length: 134  Bit Score: 174.78  E-value: 8.40e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577080 740 QIKLDPSPQTIYKWIKDNISPKLHVDKGFVNILMTSFLQYISSEvnppsdetdsssapsKEQLEQEKQLLLSFKPVMQKF 819
Cdd:cd11559   13 LLQEDPNPDELYKWIKENVSPELYASPGFVRALMTAVLKYAIEE---------------KSLPEKEKALLEKYAPLLQKY 77
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 289577080 820 LHDHVDLQVSALYALQVHCYNSNFPKGMLLRFFVHFYDMEIIEEEAFLAWKEDITQE 876
Cdd:cd11559   78 LDDDEQLQLQALYALQALVHTLEFPKGLLLRFFDALYDEDVIEEEAFLKWKEDVDPA 134
MIF4G pfam02854
MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). ...
78-308 2.47e-50

MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA.


Pssm-ID: 397130  Cd Length: 203  Bit Score: 176.01  E-value: 2.47e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577080   78 FRKVRGILNKLTPEKFDKLCLELLNVGVESKLILKGVILLIVDKALEEPKYSSLYAQLCLRLAedapnfdgpaaegqpgQ 157
Cdd:pfam02854   1 LKKVKGILNKLSPENFEKLIKELLKLIMSDPELLKYLIELIFEKAVEEPNFIPAYARLCSGLN----------------L 64
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577080  158 KQSTTFRRLLISKLQDEFENRtrnvdvydkrenpllPEEEEQRAIAKIKMLGNIKFIGELGKLDLIHESILHKCIKTLLE 237
Cdd:pfam02854  65 RNPTDFGIHLLNRLQEEFEKR---------------FELEENEQGNRRRRLGLVRFLGELYKFGLLTEKILFECLKELLS 129
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 289577080  238 KKKRVQLKDMGEDLECLCQIMRTVGPRLDHERAKSLMDQYFARMCSLMLSK---ELPARIRFLLQDTVELREHH 308
Cdd:pfam02854 130 SLTKEDLKRDLFNLECLLTLLTTIGKLLENEKLPKLMDQFLDEIQKYVLSKddpKLSSRLRFMLQDLIELRKNK 203
MIF4G smart00543
Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The ...
79-308 1.49e-43

Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA. Ponting (TiBS) "Novel eIF4G domain homologues (in press)


Pssm-ID: 214713  Cd Length: 200  Bit Score: 156.75  E-value: 1.49e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577080    79 RKVRGILNKLTPEKFDKLCLELLNVGVESKLILKGVILLIVDKALEEPKYSSLYAQLCLRLAEDAPNFdgpaaegqpgqk 158
Cdd:smart00543   2 KKVKGLINKLSPSNFESIIKELLKLNNSDKNLRKYILELIFEKAVEEPNFIPAYARLCALLNAKNPDF------------ 69
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577080   159 qsttfRRLLISKLQDEFENRtrnvdvydkrenpllpeEEEQRAIAKIKMLGNIKFIGELGKLDLIHESILHKCIKTLLEK 238
Cdd:smart00543  70 -----GSLLLERLQEEFEKG-----------------LESEEESDKQRRLGLVRFLGELYNFQVLTSKIILELLKELLND 127
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 289577080   239 KKRVQLKDMGEDLECLCQIMRTVGPRLDHERAKSLMDQYFARMCSLMLSK---ELPARIRFLLQDTVELREHH 308
Cdd:smart00543 128 LTKLDPPRSDFSVECLLSLLPTCGKDLEREKSPKLLDEILERLQDYLLKKdktELSSRLRFMLELLIELRKNK 200
MA3 smart00544
Domain in DAP-5, eIF4G, MA-3 and other proteins; Highly alpha-helical. May contain repeats and ...
544-657 2.87e-28

Domain in DAP-5, eIF4G, MA-3 and other proteins; Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains Ponting (TIBS) "Novel eIF4G domain homologues" in press


Pssm-ID: 214714  Cd Length: 113  Bit Score: 109.64  E-value: 2.87e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577080   544 LLKLTETVVTEYLNSGNANEAVNGVREMRAPkHFLPEMLSKVIILSLDRSDEDKEKASSLISLLKQEGIATSDNFMQAFL 623
Cdd:smart00544   1 LKKKIFLIIEEYLSSGDTDEAVHCLLELKLP-EQHHEVVKVLLTCALEEKRTYREMYSVLLSRLCQANVISTKQFEKGFW 79
                           90       100       110
                   ....*....|....*....|....*....|....
gi 289577080   624 NVLDQCPKLEVDIPLVKSYLAQFAARAIISELVS 657
Cdd:smart00544  80 RLLEDIEDLELDIPNAWRNLAEFVARLISDGILP 113
eIF5C smart00515
Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5;
814-894 2.45e-24

Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5;


Pssm-ID: 214705  Cd Length: 83  Bit Score: 97.36  E-value: 2.45e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577080   814 PVMQKFLHDHVDLQVSALYALQVHCYNSNFPKGMLLRFFVHFYDMEIIEEEAFLAWKEDITQEfPGKGKALFQVNQWLTW 893
Cdd:smart00515   1 GPLLKFLAKDEEEQLELLYAIEEFCVELEKLGKLLPKILKSLYDADILEEEAILKWYEKAVSA-EGKKKVRKNAKPFVTW 79

                   .
gi 289577080   894 L 894
Cdd:smart00515  80 L 80
W2 pfam02020
eIF4-gamma/eIF5/eIF2-epsilon; This domain of unknown function is found at the C-terminus of ...
827-895 7.92e-20

eIF4-gamma/eIF5/eIF2-epsilon; This domain of unknown function is found at the C-terminus of several translation initiation factors.


Pssm-ID: 460415  Cd Length: 76  Bit Score: 84.12  E-value: 7.92e-20
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 289577080  827 QVSALYALQVHCYNSNFPKGMLLRFFVHFYDMEIIEEEAFLAWKEDITQEFPGKGKALFQVNQWLTWLE 895
Cdd:pfam02020   1 QVDLLLALQEFCAKLEELLKLLLKILKALYDLDIVEEEAILKWWEDVSSAEKGMKKVRKQAKPFVEWLE 69
MA3 pfam02847
MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain ...
546-654 3.06e-15

MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains.


Pssm-ID: 397128  Cd Length: 113  Bit Score: 72.69  E-value: 3.06e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577080  546 KLTETVVTEYLNSGNANEAVNGVREMRAPkHFLPEMLSKVIILSLDRSDEDKEKASSLISLLKQEGIATSDNFMQAFLNV 625
Cdd:pfam02847   3 RKIFLILEEYLSSGDYDEAARCLLKLGLP-SQHHEVVKVLIECALEESKTYREFYGLLLERLCEFNLISTKQFEKGFWRV 81
                          90       100
                  ....*....|....*....|....*....
gi 289577080  626 LDQCPKLEVDIPLVKSYLAQFAARAIISE 654
Cdd:pfam02847  82 LEDLEDLELDIPNAWRNLAEFVARLISDD 110
W2_eIF2B_epsilon cd11558
C-terminal W2 domain of eukaryotic translation initiation factor 2B epsilon; eIF2B is a ...
772-894 7.44e-12

C-terminal W2 domain of eukaryotic translation initiation factor 2B epsilon; eIF2B is a heteropentameric complex which functions as a guanine nucleotide exchange factor in the recycling of eIF-2 during the initiation of translation in eukaryotes. The epsilon and gamma subunits are sequence similar and both are essential in yeast. Epsilon appears to be the catalytically active subunit, with gamma enhancing its activity. The C-terminal domain of the eIF2B epsilon subunit contains bipartite motifs rich in acidic and aromatic residues, which are responsible for the interaction with eIF2. The structure of the domain resembles that of a set of concatenated HEAT repeats.


Pssm-ID: 211396  Cd Length: 169  Bit Score: 64.59  E-value: 7.44e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577080 772 LMTSFLQYISSevnppsdetdSSSAPSKEQLEQEKQLLLSFKPVMQKFLHDHVDlQVSALYALQVHC-YNSNFPKgmLLR 850
Cdd:cd11558   49 VVKALLELILE----------VSSTSTAELLEALKKLLSKWGPLLENYVKSQDD-QVELLLALEEFClESEEGGP--LFA 115
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 289577080 851 FFVH-FYDMEIIEEEAFLAWKEDITQEFPGKGKALF-QVNQWLTWL 894
Cdd:cd11558  116 KLLHaLYDLDILEEEAILEWWEEPDAGADEEMKKVReLVKKFIEWL 161
W2 cd11473
C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon; This domain is found at the C-terminus of ...
750-869 3.91e-10

C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon; This domain is found at the C-terminus of several translation initiation factors, including the epsilon chain of eIF2b, where it has been found to catalyze the conversion of eIF2.GDP to its active eIF2.GTP form. The structure of the domain resembles that of a set of concatenated HEAT repeats.


Pssm-ID: 211395  Cd Length: 135  Bit Score: 58.64  E-value: 3.91e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577080 750 IYKWIKDNISPKLHVDKGFVNILMTSFLQYISSEVnppsdetdsssAPSKEQLEQEKQLLLSFKPVMQKFLHDHVDLQVS 829
Cdd:cd11473   24 SVKAAKSKLDLDPISLEEVVKVLLTAVVNAVESAD-----------SISLTQKEQLVLVLKKYGPVLRELLKLIKKDQLY 92
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 289577080 830 ALYALQVHCY---NSNFPKgMLLRFFVHFYDMEIIEEEAFLAW 869
Cdd:cd11473   93 LLLKIEKLCLqlkLSELIS-LLEKILDLLYDADVLSEEAILSW 134
PRK12757 PRK12757
cell division protein FtsN; Provisional
436-543 2.82e-04

cell division protein FtsN; Provisional


Pssm-ID: 237191 [Multi-domain]  Cd Length: 256  Bit Score: 43.49  E-value: 2.82e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577080 436 SQLYHNQSQgLLSQLQGqskDM--PPRfskkgQLNA---DEISLRPAQSFLMNKNQVPKLQPQITMIPPS-AQPPRTQTP 509
Cdd:PRK12757  78 TQLTDEQRQ-LLEQMQA---DMrqQPT-----QLSEvpyNEQTPQVPRSTVQIQQQAQQQQPPATTAQPQpVTPPRQTTA 148
                         90       100       110
                 ....*....|....*....|....*....|....
gi 289577080 510 PlgQTPQLGLKTNPPliQEKPAKTSKKPPPSKEE 543
Cdd:PRK12757 149 P--VQPQTPAPVRTQ--PAAPVTQAVEAPKVEAE 178
W2_eIF5C_like cd11560
C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins; ...
826-894 6.82e-04

C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins; eIF5C appears to be essential for the initiation of protein translation; its actual function, and specifically that of the C-terminal W2 domain, are not well understood. The Drosophila ortholog, kra (krasavietz) or exba (extra bases), may be involved in translational inhibition in neural development. The structure of this C-terminal domain resembles that of a set of concatenated HEAT repeats.


Pssm-ID: 211398 [Multi-domain]  Cd Length: 194  Bit Score: 41.81  E-value: 6.82e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 289577080 826 LQVSALYALQVHCY-NSNFPKgMLLRFFVHFYDMEIIEEEAFLAWKEDitqEFPGKGKALF--QVNQWLTWL 894
Cdd:cd11560  121 AELALLNKIQEYCYeNMKFMK-VFQKIVKLLYKADVLSEDAILKWYKK---GHSPKGKQVFlkQMEPFVEWL 188
Med15 pfam09606
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of ...
357-541 3.25e-03

ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development.


Pssm-ID: 312941 [Multi-domain]  Cd Length: 732  Bit Score: 41.15  E-value: 3.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577080  357 MPPRMKMDRDPLGGLADMFGQMPGsgiGTGPGVIQDRFSPTMGRHRSNQLFNGHGGHIMPP-------TQSQFGEMGGKF 429
Cdd:pfam09606 246 QQPQQQGQQSQLGMGINQMQQMPQ---GVGGGAGQGGPGQPMGPPGQQPGAMPNVMSIGDQnnyqqqqTRQQQQQQGGNH 322
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289577080  430 MKSQGLSQLYHNQSQGLLSQLQGQSKDMPPRFSKKGQLNADeiSLRPAQSFLMNKNQVPKLQ-------PQITMIPPSAQ 502
Cdd:pfam09606 323 PAAHQQQMNQSVGQGGQVVALGGLNHLETWNPGNFGGLGAN--PMQRGQPGMMSSPSPVPGQqvrqvtpNQFMRQSPQPS 400
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 289577080  503 PPRTQTPPL--GQTPQLGLKTNPPLIQEKPAKTSKKPPPSK 541
Cdd:pfam09606 401 VPSPQGPGSqpPQSHPGGMIPSPALIPSPSPQMSQQPAQQR 441
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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