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Conserved domains on  [gi|4504205|ref|NP_001512|]
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general transcription factor 3C polypeptide 2 isoform b [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 559-644 6.70e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 51.95  E-value: 6.70e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504205  559 SLAWMPTrpHQHLAAGYYNGMVVFWNLPTNSPLQRIRL---------------------SDGSLKLY------PFQCFLA 611
Cdd:cd00200 140 SVAFSPD--GTFVASSSQDGTIKLWDLRTGKCVATLTGhtgevnsvafspdgekllsssSDGTIKLWdlstgkCLGTLRG 217

                        90       100       110
                ....*....|....*....|....*....|...
gi 4504205  612 HDQAVRTLQWCKaNSHFLVSAGSDRKIKFWDLR 644
Cdd:cd00200 218 HENGVNSVAFSP-DGYLLASGSEDGTIRVWDLR 249
PTZ00449 super family cl33186
104 kDa microneme/rhoptry antigen; Provisional
 62-255 4.05e-05

104 kDa microneme/rhoptry antigen; Provisional


The actual alignment was detected with superfamily member PTZ00449:

Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 47.38  E-value: 4.05e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504205    62 DSPDQRRLPPEQESLSRLEQPDLSSEMSKVSKPRASKpgRKRGGRTRKGPKRPQQPNPPSAPLVPglldqSNPLSTPMPK 141
Cdd:PTZ00449 541 DEPKEGGKPGETKEGEVGKKPGPAKEHKPSKIPTLSK--KPEFPKDPKHPKDPEEPKKPKRPRSA-----QRPTRPKSPK 613

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504205   142 KrgrkskaeLLLLKLSKDLDRPES-QSPKRPPEDFETPSGERP------------------------------------R 184
Cdd:PTZ00449 614 L--------PELLDIPKSPKRPESpKSPKRPPPPQRPSSPERPegpkiikspkppkspkppfdpkfkekfyddyldaaaK 685

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4504205   185 RRAAQVALLYLQELAEELSTALPAPVSCPegPKVSSPTKPKKIRQPAAC--PGGEEVDGAPRDEDFFLQVEAE 255
Cdd:PTZ00449 686 SKETKTTVVLDESFESILKETLPETPGTP--FTTPRPLPPKLPRDEEFPfePIGDPDAEQPDDIEFFTPPEEE 756
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 559-644 6.70e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 51.95  E-value: 6.70e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504205  559 SLAWMPTrpHQHLAAGYYNGMVVFWNLPTNSPLQRIRL---------------------SDGSLKLY------PFQCFLA 611
Cdd:cd00200 140 SVAFSPD--GTFVASSSQDGTIKLWDLRTGKCVATLTGhtgevnsvafspdgekllsssSDGTIKLWdlstgkCLGTLRG 217

                        90       100       110
                ....*....|....*....|....*....|...
gi 4504205  612 HDQAVRTLQWCKaNSHFLVSAGSDRKIKFWDLR 644
Cdd:cd00200 218 HENGVNSVAFSP-DGYLLASGSEDGTIRVWDLR 249
WD40 COG2319
WD40 repeat [General function prediction only];
541-644 1.78e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 51.45  E-value: 1.78e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504205  541 LQVGSMQATDPSECGQCLSLAWMPTRphQHLAAGYYNGMVVFWNLPTNSPLQRirlsdgslklypfqcFLAHDQAVRTLQ 620
Cdd:COG2319 317 LATGKLLRTLTGHTGAVRSVAFSPDG--KTLASGSDDGTVRLWDLATGELLRT---------------LTGHTGAVTSVA 379

                        90       100
                ....*....|....*....|....
gi 4504205  621 WcKANSHFLVSAGSDRKIKFWDLR 644
Cdd:COG2319 380 F-SPDGRTLASGSADGTVRLWDLA 402
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 62-255 4.05e-05

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 47.38  E-value: 4.05e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504205    62 DSPDQRRLPPEQESLSRLEQPDLSSEMSKVSKPRASKpgRKRGGRTRKGPKRPQQPNPPSAPLVPglldqSNPLSTPMPK 141
Cdd:PTZ00449 541 DEPKEGGKPGETKEGEVGKKPGPAKEHKPSKIPTLSK--KPEFPKDPKHPKDPEEPKKPKRPRSA-----QRPTRPKSPK 613

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504205   142 KrgrkskaeLLLLKLSKDLDRPES-QSPKRPPEDFETPSGERP------------------------------------R 184
Cdd:PTZ00449 614 L--------PELLDIPKSPKRPESpKSPKRPPPPQRPSSPERPegpkiikspkppkspkppfdpkfkekfyddyldaaaK 685

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4504205   185 RRAAQVALLYLQELAEELSTALPAPVSCPegPKVSSPTKPKKIRQPAAC--PGGEEVDGAPRDEDFFLQVEAE 255
Cdd:PTZ00449 686 SKETKTTVVLDESFESILKETLPETPGTP--FTTPRPLPPKLPRDEEFPfePIGDPDAEQPDDIEFFTPPEEE 756
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 605-642 5.87e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.14  E-value: 5.87e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 4504205     605 PFQCFLAHDQAVRTLQWCKaNSHFLVSAGSDRKIKFWD 642
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
TALPID3 pfam15324
Hedgehog signalling target; TALPID3 is a family of eukaryotic proteins that are targets for ...
 37-238 2.39e-04

Hedgehog signalling target; TALPID3 is a family of eukaryotic proteins that are targets for Hedgehog signalling. Mutations in this gene noticed first in chickens lead to multiple abnormalities of development.


Pssm-ID: 434634 [Multi-domain]  Cd Length: 1288  Bit Score: 45.26  E-value: 2.39e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504205      37 KTSSEMTSAEASV---EMSLPTPLPGFEDSPDQRRlPPEQESLSRLEQPDLSSEMSKVS-KPRASKPgrkrggrtrkgPK 112
Cdd:pfam15324  965 REPPVAASVPGDLptkETLLPTPVPTPQPTPPCSP-PSPLKEPSPVKTPDSSPCVSEHDfFPVKEIP-----------PE 1032

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504205     113 RPQQPNPPSAPLvpglldqSNPLSTPMPKKRGRKSKAELLLLKLSKDLDRPESQSPKrPPEDFETPSGE---RPRRRAAQ 189
Cdd:pfam15324 1033 KGADTGPAVSLV-------ITPTVTPIATPPPAATPTPPLSENSIDKLKSPSPELPK-PWEDSDLPLEEenpNSEQEELH 1104

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*....
gi 4504205     190 VALLYLQELAEELSTALPAPVSCPEGPKVSSPTKPKKIRQPAACPGGEE 238
Cdd:pfam15324 1105 PRAVVMSVARDEEPESVVLPASPPEPKPLAPPPLGAAPPSPPQSPSSSS 1153
WD40 pfam00400
WD domain, G-beta repeat;
605-642 3.82e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.87  E-value: 3.82e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 4504205    605 PFQCFLAHDQAVRTLQWCKaNSHFLVSAGSDRKIKFWD 642
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 559-644 6.70e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 51.95  E-value: 6.70e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504205  559 SLAWMPTrpHQHLAAGYYNGMVVFWNLPTNSPLQRIRL---------------------SDGSLKLY------PFQCFLA 611
Cdd:cd00200 140 SVAFSPD--GTFVASSSQDGTIKLWDLRTGKCVATLTGhtgevnsvafspdgekllsssSDGTIKLWdlstgkCLGTLRG 217

                        90       100       110
                ....*....|....*....|....*....|...
gi 4504205  612 HDQAVRTLQWCKaNSHFLVSAGSDRKIKFWDLR 644
Cdd:cd00200 218 HENGVNSVAFSP-DGYLLASGSEDGTIRVWDLR 249
WD40 COG2319
WD40 repeat [General function prediction only];
541-644 1.78e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 51.45  E-value: 1.78e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504205  541 LQVGSMQATDPSECGQCLSLAWMPTRphQHLAAGYYNGMVVFWNLPTNSPLQRirlsdgslklypfqcFLAHDQAVRTLQ 620
Cdd:COG2319 317 LATGKLLRTLTGHTGAVRSVAFSPDG--KTLASGSDDGTVRLWDLATGELLRT---------------LTGHTGAVTSVA 379

                        90       100
                ....*....|....*....|....
gi 4504205  621 WcKANSHFLVSAGSDRKIKFWDLR 644
Cdd:COG2319 380 F-SPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 555-644 4.33e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 49.64  E-value: 4.33e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504205  555 GQCLSLAWMPtrPHQHLAAGYYNGMVVFWNLPTNSPLQRirlsdgslklypfqcFLAHDQAVRTLQWCkANSHFLVSAGS 634
Cdd:cd00200  10 GGVTCVAFSP--DGKLLATGSGDGTIKVWDLETGELLRT---------------LKGHTGPVRDVAAS-ADGTYLASGSS 71

                        90
                ....*....|
gi 4504205  635 DRKIKFWDLR 644
Cdd:cd00200  72 DKTIRLWDLE 81
WD40 COG2319
WD40 repeat [General function prediction only];
559-646 8.17e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 49.14  E-value: 8.17e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504205  559 SLAWMPTRphQHLAAGYYNGMVVFWNLPTNSPLQRIRlsdgslklypfqcflAHDQAVRTLQWCkANSHFLVSAGSDRKI 638
Cdd:COG2319 167 SVAFSPDG--KLLASGSDDGTVRLWDLATGKLLRTLT---------------GHTGAVRSVAFS-PDGKLLASGSADGTV 228


                ....*...
gi 4504205  639 KFWDLRRP 646
Cdd:COG2319 229 RLWDLATG 236
WD40 COG2319
WD40 repeat [General function prediction only];
559-644 9.31e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 49.14  E-value: 9.31e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504205  559 SLAWMPTRphQHLAAGYYNGMVVFWNLPTNSPLQRIRlsdgslklypfqcflAHDQAVRTLQWCkANSHFLVSAGSDRKI 638
Cdd:COG2319 209 SVAFSPDG--KLLASGSADGTVRLWDLATGKLLRTLT---------------GHSGSVRSVAFS-PDGRLLASGSADGTV 270


                ....*.
gi 4504205  639 KFWDLR 644
Cdd:COG2319 271 RLWDLA 276
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 503-644 9.77e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 48.49  E-value: 9.77e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504205  503 CSDGKVLLFSLPHPEALLAQQPPdavKPAIYKVQCVA------------TLQVGSMQATDPSE-----CGQCLSLAWMPT 565
Cdd:cd00200  28 SGDGTIKVWDLETGELLRTLKGH---TGPVRDVAASAdgtylasgssdkTIRLWDLETGECVRtltghTSYVSSVAFSPD 104

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504205  566 RphQHLAAGYYNGMVVFWNLPTNSPLQRIR---------------------LSDGSLKLY---PFQC---FLAHDQAVRT 618
Cdd:cd00200 105 G--RILSSSSRDKTIKVWDVETGKCLTTLRghtdwvnsvafspdgtfvassSQDGTIKLWdlrTGKCvatLTGHTGEVNS 182

                       170       180
                ....*....|....*....|....*.
gi 4504205  619 LQWCKANSHFLvSAGSDRKIKFWDLR 644
Cdd:cd00200 183 VAFSPDGEKLL-SSSSDGTIKLWDLS 207
WD40 COG2319
WD40 repeat [General function prediction only];
558-644 1.02e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 48.75  E-value: 1.02e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504205  558 LSLAWMPTRphQHLAAGYYNGMVVFWNLPTNSPLQRI-----------------RL----SDGSLKLY------PFQCFL 610
Cdd:COG2319 250 RSVAFSPDG--RLLASGSADGTVRLWDLATGELLRTLtghsggvnsvafspdgkLLasgsDDGTVRLWdlatgkLLRTLT 327

                        90       100       110
                ....*....|....*....|....*....|....
gi 4504205  611 AHDQAVRTLQWcKANSHFLVSAGSDRKIKFWDLR 644
Cdd:COG2319 328 GHTGAVRSVAF-SPDGKTLASGSDDGTVRLWDLA 360
WD40 COG2319
WD40 repeat [General function prediction only];
569-644 2.98e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 47.60  E-value: 2.98e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4504205  569 QHLAAGYYNGMVVFWNLPTNSPLQRIRlsdgslklypfqcflAHDQAVRTLQWCkANSHFLVSAGSDRKIKFWDLR 644
Cdd:COG2319 133 KTLASGSADGTVRLWDLATGKLLRTLT---------------GHSGAVTSVAFS-PDGKLLASGSDDGTVRLWDLA 192
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 62-255 4.05e-05

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 47.38  E-value: 4.05e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504205    62 DSPDQRRLPPEQESLSRLEQPDLSSEMSKVSKPRASKpgRKRGGRTRKGPKRPQQPNPPSAPLVPglldqSNPLSTPMPK 141
Cdd:PTZ00449 541 DEPKEGGKPGETKEGEVGKKPGPAKEHKPSKIPTLSK--KPEFPKDPKHPKDPEEPKKPKRPRSA-----QRPTRPKSPK 613

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504205   142 KrgrkskaeLLLLKLSKDLDRPES-QSPKRPPEDFETPSGERP------------------------------------R 184
Cdd:PTZ00449 614 L--------PELLDIPKSPKRPESpKSPKRPPPPQRPSSPERPegpkiikspkppkspkppfdpkfkekfyddyldaaaK 685

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4504205   185 RRAAQVALLYLQELAEELSTALPAPVSCPegPKVSSPTKPKKIRQPAAC--PGGEEVDGAPRDEDFFLQVEAE 255
Cdd:PTZ00449 686 SKETKTTVVLDESFESILKETLPETPGTP--FTTPRPLPPKLPRDEEFPfePIGDPDAEQPDDIEFFTPPEEE 756
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 536-642 5.09e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 46.17  E-value: 5.09e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504205  536 QCVATLQvgsmqatdpSECGQCLSLAWMPTRphQHLAAGYYNGMVVFWNLPTNSPLQRIRlsdgslklypfqcflAHDQA 615
Cdd:cd00200 210 KCLGTLR---------GHENGVNSVAFSPDG--YLLASGSEDGTIRVWDLRTGECVQTLS---------------GHTNS 263

                        90       100
                ....*....|....*....|....*..
gi 4504205  616 VRTLQWCkANSHFLVSAGSDRKIKFWD 642
Cdd:cd00200 264 VTSLAWS-PDGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 605-642 5.87e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.14  E-value: 5.87e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 4504205     605 PFQCFLAHDQAVRTLQWCKaNSHFLVSAGSDRKIKFWD 642
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
TALPID3 pfam15324
Hedgehog signalling target; TALPID3 is a family of eukaryotic proteins that are targets for ...
 37-238 2.39e-04

Hedgehog signalling target; TALPID3 is a family of eukaryotic proteins that are targets for Hedgehog signalling. Mutations in this gene noticed first in chickens lead to multiple abnormalities of development.


Pssm-ID: 434634 [Multi-domain]  Cd Length: 1288  Bit Score: 45.26  E-value: 2.39e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504205      37 KTSSEMTSAEASV---EMSLPTPLPGFEDSPDQRRlPPEQESLSRLEQPDLSSEMSKVS-KPRASKPgrkrggrtrkgPK 112
Cdd:pfam15324  965 REPPVAASVPGDLptkETLLPTPVPTPQPTPPCSP-PSPLKEPSPVKTPDSSPCVSEHDfFPVKEIP-----------PE 1032

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504205     113 RPQQPNPPSAPLvpglldqSNPLSTPMPKKRGRKSKAELLLLKLSKDLDRPESQSPKrPPEDFETPSGE---RPRRRAAQ 189
Cdd:pfam15324 1033 KGADTGPAVSLV-------ITPTVTPIATPPPAATPTPPLSENSIDKLKSPSPELPK-PWEDSDLPLEEenpNSEQEELH 1104

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*....
gi 4504205     190 VALLYLQELAEELSTALPAPVSCPEGPKVSSPTKPKKIRQPAACPGGEE 238
Cdd:pfam15324 1105 PRAVVMSVARDEEPESVVLPASPPEPKPLAPPPLGAAPPSPPQSPSSSS 1153
WD40 pfam00400
WD domain, G-beta repeat;
605-642 3.82e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.87  E-value: 3.82e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 4504205    605 PFQCFLAHDQAVRTLQWCKaNSHFLVSAGSDRKIKFWD 642
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
PHA03247 PHA03247
large tegument protein UL36; Provisional
 47-244 6.01e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.77  E-value: 6.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504205     47 ASVEMSLPTPLPgfedSPDqrrlPPEQESLSRLEQPDLSSEMSKVSKPRASKPGRKRGGRTRKGPKRPQQPNPPSAPLVP 126
Cdd:PHA03247 2562 AAPDRSVPPPRP----APR----PSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSP 2633

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504205    127 GLLDQSNPLSTPMPkkrgrKSKAELLLLKLSKDLDRPESQSPKRPPEDFETPsgERPRRRAAQVALLYLQELAEELST-A 205
Cdd:PHA03247 2634 AANEPDPHPPPTVP-----PPERPRDDPAPGRVSRPRRARRLGRAAQASSPP--QRPRRRAARPTVGSLTSLADPPPPpP 2706

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 4504205    206 LPAPVSCPEGPKVSSPTKPKKIRQ----------PAACPGGEEVDGAPR 244
Cdd:PHA03247 2707 TPEPAPHALVSATPLPPGPAAARQaspalpaapaPPAVPAGPATPGGPA 2755
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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