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Conserved domains on  [gi|4502425|ref|NP_001709|]
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bone morphogenetic protein 6 preproprotein [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TGFb_propeptide pfam00688
TGF-beta propeptide; This propeptide is known as latency associated peptide (LAP) in TGF-beta. ...
 65-362 4.60e-106

TGF-beta propeptide; This propeptide is known as latency associated peptide (LAP) in TGF-beta. LAP is a homodimer which is disulfide linked to TGF-beta binding protein.


:

Pssm-ID: 459906  Cd Length: 239  Bit Score: 316.57  E-value: 4.60e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502425     65 GFLYRRLKTQEKREMQKEILSVLGLPHRPRPLhglqqpqppalrqqeeqqqqqqlprgeppPGRLKSAPLFMLDLYNALS 144
Cdd:pfam00688   6 TVDHRRLKSKEKREIEHEILSLLGLPHRPRPS-----------------------------SGKHKSAPQFMLDLYNSTS 56

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502425    145 ADNDEDGASEGERQQSWPheaasssqrrqpppgaahplnrksllapgsgsggaspLTSAQDSAFLNDADMVMSFVNLVEY 224
Cdd:pfam00688  57 GEEEEKERQSRLSTRSEP-------------------------------------LLTLQDSRAIDEADTVMSFVNKVEN 99

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502425    225 DKEFSPRQRHHKEFKFNLSQIPEGEVVTAAEFRIYKDCVMGSFKNQTFLISIYQVLQEHQHRDSDLFLLDTRVVWASEEG 304
Cdd:pfam00688 100 HHVPDLRHEEGKRFWFNLSEIPEGELVTSAELRLYKDKVKARTSNETFRIEVYQVLKEHDGGDASLRLLDSRLVTASEEG 179

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502425    305 WLEFDITATSNLWVVTPQHNMGLQLSVVT--RDGVHVHPRAAGLVGRDGPYDKQPFMVAF 362
Cdd:pfam00688 180 WLSFDVTEALNRWLANPEENLGLQLSVHCscRSGREIKPDDVGLVGRRGWDQKQPFLVTF 239
TGF_beta_BMP6 cd19396
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 6 ...
 411-513 5.23e-77

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 6 (BMP-6) and similar proteins; BMP-6, also termed VG-1-related protein, or VG-1-R, or VGR-1, induces cartilage and bone formation.


:

Pssm-ID: 381666  Cd Length: 103  Bit Score: 236.86  E-value: 5.23e-77
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502425  411 ACRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVHLMNPEYVPKPCCAPTKLNAISVLY 490
Cdd:cd19396   1 ACRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVHLMNPEYVPKPCCAPTKLNAISVLY 80

                        90       100
                ....*....|....*....|...
gi 4502425  491 FDDNSNVILKKYRNMVVRACGCH 513
Cdd:cd19396  81 FDDNSNVILKKYRNMVVRACGCH 103
 
Name Accession Description Interval E-value
TGFb_propeptide pfam00688
TGF-beta propeptide; This propeptide is known as latency associated peptide (LAP) in TGF-beta. ...
 65-362 4.60e-106

TGF-beta propeptide; This propeptide is known as latency associated peptide (LAP) in TGF-beta. LAP is a homodimer which is disulfide linked to TGF-beta binding protein.


Pssm-ID: 459906  Cd Length: 239  Bit Score: 316.57  E-value: 4.60e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502425     65 GFLYRRLKTQEKREMQKEILSVLGLPHRPRPLhglqqpqppalrqqeeqqqqqqlprgeppPGRLKSAPLFMLDLYNALS 144
Cdd:pfam00688   6 TVDHRRLKSKEKREIEHEILSLLGLPHRPRPS-----------------------------SGKHKSAPQFMLDLYNSTS 56

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502425    145 ADNDEDGASEGERQQSWPheaasssqrrqpppgaahplnrksllapgsgsggaspLTSAQDSAFLNDADMVMSFVNLVEY 224
Cdd:pfam00688  57 GEEEEKERQSRLSTRSEP-------------------------------------LLTLQDSRAIDEADTVMSFVNKVEN 99

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502425    225 DKEFSPRQRHHKEFKFNLSQIPEGEVVTAAEFRIYKDCVMGSFKNQTFLISIYQVLQEHQHRDSDLFLLDTRVVWASEEG 304
Cdd:pfam00688 100 HHVPDLRHEEGKRFWFNLSEIPEGELVTSAELRLYKDKVKARTSNETFRIEVYQVLKEHDGGDASLRLLDSRLVTASEEG 179

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502425    305 WLEFDITATSNLWVVTPQHNMGLQLSVVT--RDGVHVHPRAAGLVGRDGPYDKQPFMVAF 362
Cdd:pfam00688 180 WLSFDVTEALNRWLANPEENLGLQLSVHCscRSGREIKPDDVGLVGRRGWDQKQPFLVTF 239
TGF_beta_BMP6 cd19396
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 6 ...
 411-513 5.23e-77

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 6 (BMP-6) and similar proteins; BMP-6, also termed VG-1-related protein, or VG-1-R, or VGR-1, induces cartilage and bone formation.


Pssm-ID: 381666  Cd Length: 103  Bit Score: 236.86  E-value: 5.23e-77
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502425  411 ACRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVHLMNPEYVPKPCCAPTKLNAISVLY 490
Cdd:cd19396   1 ACRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVHLMNPEYVPKPCCAPTKLNAISVLY 80

                        90       100
                ....*....|....*....|...
gi 4502425  491 FDDNSNVILKKYRNMVVRACGCH 513
Cdd:cd19396  81 FDDNSNVILKKYRNMVVRACGCH 103
TGFB smart00204
Transforming growth factor-beta (TGF-beta) family; Family members are active as ...
 412-513 5.76e-62

Transforming growth factor-beta (TGF-beta) family; Family members are active as disulphide-linked homo- or heterodimers. TGFB is a multifunctional peptide that controls proliferation, differentiation, and other functions in many cell types.


Pssm-ID: 214556  Cd Length: 102  Bit Score: 197.88  E-value: 5.76e-62
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502425     412 CRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVHLMNPEYVPKPCCAPTKLNAISVLYF 491
Cdd:smart00204   1 CRRRQLYVDFKDLGWDDWIIAPKGYNAYYCEGECPFPLSTSLNATNHAIVQTLVHLLGPNPVPKPCCVPTKLSPLSMLYY 80

                           90       100
                   ....*....|....*....|..
gi 4502425     492 DDNSNVILKKYRNMVVRACGCH 513
Cdd:smart00204  81 DDDGNVVLRNYPNMVVEECGCR 102
TGF_beta pfam00019
Transforming growth factor beta like domain;
412-512 5.93e-59

Transforming growth factor beta like domain;


Pssm-ID: 459632  Cd Length: 102  Bit Score: 189.84  E-value: 5.93e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502425    412 CRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVHLMNPEYVPKPCCAPTKLNAISVLYF 491
Cdd:pfam00019   2 CRRHSLYVDFEDLGWDDWIIAPKGYNAYYCSGSCPSHLNPQLSATNHAILQSLLHSLKPANVPKPCCVPTKLSPLSVLYY 81

                          90       100
                  ....*....|....*....|.
gi 4502425    492 DDNSNVILKKYRNMVVRACGC 512
Cdd:pfam00019  82 DDEGNVVLKTYPDMVVESCGC 102
PHA02913 PHA02913
TGF-beta-like protein; Provisional
 404-512 3.88e-10

TGF-beta-like protein; Provisional


Pssm-ID: 177497  Cd Length: 172  Bit Score: 58.88  E-value: 3.88e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502425   404 NSSELKTACRKHELYVSFQ-DLGWQdWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQtlvHLMNPEYVPKpCCAPTK 482
Cdd:PHA02913  69 DFCDIDAICCIRDFNIDFKaDMGMK-WILKPEGTHANLCIGICSISNHKKINLMYGTAFK---HHMPDNTIPF-CCAPIK 143

                         90       100       110
                 ....*....|....*....|....*....|
gi 4502425   483 LNAISVLYFdDNSNVILKKYRNMVVRACGC 512
Cdd:PHA02913 144 MKNFIIAYK-EGRKIKTDNIKNFKILECAC 172
DNRLRE_dom NF033679
DNRLRE domain; The DNRLRE domain, with a length of about 160 amino acids, appears typically in ...
 239-329 6.69e-04

DNRLRE domain; The DNRLRE domain, with a length of about 160 amino acids, appears typically in large, repetitive surface proteins of bacteria and archaea, sometimes repeated several times. It occurs, notably, three times in the C-terminal region of the enzyme disaggregatase from the archaeal species Methanosarcina mazei, each time with the motif DNRLRE, for which the domain is named. Archaeal proteins within this family are described particularly well by the currently more narrowly defined Pfam model, PF06848. Note that the catalytic region of disaggregatase, in the N-terminal portion of the protein, is modeled by a different HMM, PF08480.


Pssm-ID: 468137 [Multi-domain]  Cd Length: 164  Bit Score: 40.44  E-value: 6.69e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502425   239 KFNLSQIPEGEVVTAAEFRIYKDCVMGSFKNQTFL-ISIYQVLQE---------HQHRDSDLFLLDTrVVWASEEGWLEF 308
Cdd:NF033679  36 KFDLSSLPAGATITSATLRLYVYYSYSTDSGTSPTtVEVYRVTSDwsestvtwnNAPAAAYASITIT-VSSVPDGGWVEI 114

                         90       100
                 ....*....|....*....|.
gi 4502425   309 DITATSNLWVVTPQHNMGLQL 329
Cdd:NF033679 115 DVTDLVQAWVSGTYPNYGFLL 135
 
Name Accession Description Interval E-value
TGFb_propeptide pfam00688
TGF-beta propeptide; This propeptide is known as latency associated peptide (LAP) in TGF-beta. ...
 65-362 4.60e-106

TGF-beta propeptide; This propeptide is known as latency associated peptide (LAP) in TGF-beta. LAP is a homodimer which is disulfide linked to TGF-beta binding protein.


Pssm-ID: 459906  Cd Length: 239  Bit Score: 316.57  E-value: 4.60e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502425     65 GFLYRRLKTQEKREMQKEILSVLGLPHRPRPLhglqqpqppalrqqeeqqqqqqlprgeppPGRLKSAPLFMLDLYNALS 144
Cdd:pfam00688   6 TVDHRRLKSKEKREIEHEILSLLGLPHRPRPS-----------------------------SGKHKSAPQFMLDLYNSTS 56

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502425    145 ADNDEDGASEGERQQSWPheaasssqrrqpppgaahplnrksllapgsgsggaspLTSAQDSAFLNDADMVMSFVNLVEY 224
Cdd:pfam00688  57 GEEEEKERQSRLSTRSEP-------------------------------------LLTLQDSRAIDEADTVMSFVNKVEN 99

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502425    225 DKEFSPRQRHHKEFKFNLSQIPEGEVVTAAEFRIYKDCVMGSFKNQTFLISIYQVLQEHQHRDSDLFLLDTRVVWASEEG 304
Cdd:pfam00688 100 HHVPDLRHEEGKRFWFNLSEIPEGELVTSAELRLYKDKVKARTSNETFRIEVYQVLKEHDGGDASLRLLDSRLVTASEEG 179

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502425    305 WLEFDITATSNLWVVTPQHNMGLQLSVVT--RDGVHVHPRAAGLVGRDGPYDKQPFMVAF 362
Cdd:pfam00688 180 WLSFDVTEALNRWLANPEENLGLQLSVHCscRSGREIKPDDVGLVGRRGWDQKQPFLVTF 239
TGF_beta_BMP6 cd19396
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 6 ...
 411-513 5.23e-77

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 6 (BMP-6) and similar proteins; BMP-6, also termed VG-1-related protein, or VG-1-R, or VGR-1, induces cartilage and bone formation.


Pssm-ID: 381666  Cd Length: 103  Bit Score: 236.86  E-value: 5.23e-77
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502425  411 ACRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVHLMNPEYVPKPCCAPTKLNAISVLY 490
Cdd:cd19396   1 ACRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVHLMNPEYVPKPCCAPTKLNAISVLY 80

                        90       100
                ....*....|....*....|...
gi 4502425  491 FDDNSNVILKKYRNMVVRACGCH 513
Cdd:cd19396  81 FDDNSNVILKKYRNMVVRACGCH 103
TGF_beta_BMP5_like cd13761
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic proteins ...
 411-513 8.28e-76

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic proteins BMP-5, BMP-6, BMP-7, BMP-8A/B and similar proteins; The family includes BMP-5, BMP-6, BMP-7 and BMP-8A/B, which may induce cartilage and bone formation.


Pssm-ID: 381639  Cd Length: 103  Bit Score: 233.62  E-value: 8.28e-76
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502425  411 ACRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVHLMNPEYVPKPCCAPTKLNAISVLY 490
Cdd:cd13761   1 SCRRHNLYVDFRDLGWQDWIIAPDGYNAYYCSGECSFPLNSHMNATNHAIVQTLVHLMNPNRVPKPCCAPTKLSPISVLY 80

                        90       100
                ....*....|....*....|...
gi 4502425  491 FDDNSNVILKKYRNMVVRACGCH 513
Cdd:cd13761  81 YDDNSNVVLKKYKNMVVESCGCH 103
TGF_beta_BMP7 cd19397
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 7 ...
 407-513 1.09e-72

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 7 (BMP-7) and similar proteins; BMP-7, also termed osteogenic protein 1 (OP-1), or eptotermin alfa, induces cartilage and bone formation. It may act as the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis and play a role in calcium regulation and bone homeostasis.


Pssm-ID: 381667  Cd Length: 107  Bit Score: 226.08  E-value: 1.09e-72
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502425  407 ELKTACRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVHLMNPEYVPKPCCAPTKLNAI 486
Cdd:cd19397   1 DQRQACKKHELYVSFRDLGWQDWIIAPEGYAAYYCEGECAFPLNSYMNATNHAIVQTLVHFINPETVPKPCCAPTQLNAI 80

                        90       100
                ....*....|....*....|....*..
gi 4502425  487 SVLYFDDNSNVILKKYRNMVVRACGCH 513
Cdd:cd19397  81 SVLYFDDSSNVILKKYRNMVVRACGCH 107
TGF_beta_BMP5 cd19395
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 5 ...
 402-513 3.37e-71

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 5 (BMP-5) and similar proteins; BMP-5 induces cartilage and bone formation.


Pssm-ID: 381665  Cd Length: 113  Bit Score: 222.27  E-value: 3.37e-71
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502425  402 DYNSSELKTACRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVHLMNPEYVPKPCCAPT 481
Cdd:cd19395   2 DYNTSEQKQACKKHELYVSFRDLGWQDWIIAPEGYAAFYCDGECSFPLNAHMNATNHAIVQTLVHLMFPDNVPKPCCAPT 81

                        90       100       110
                ....*....|....*....|....*....|..
gi 4502425  482 KLNAISVLYFDDNSNVILKKYRNMVVRACGCH 513
Cdd:cd19395  82 KLNAISVLYFDDSSNVILKKYRNMVVRSCGCH 113
TGF_beta_BMP8 cd19398
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 8A ...
 409-513 1.25e-67

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 8A (BMP-8A), 8B (BMP-8B) and similar proteins; BMP-8A plays a role in the maintenance of spermatogenesis and the integrity of the epididymis. BMP-8B, also termed BMP-8, or osteogenic protein 2 (OP-2), may act as secreted factor in cancer progression. It also plays an essential role in bone metabolism and can regulate thermogenesis and energy balance. Like BMP-8A, BMP-8B plays a role in spermatogenesis and placental development. Mutation in either of the genes encoding BMP-8A or BMP-8B causes postnatal depletion of spermatogonia in mice.


Pssm-ID: 381668  Cd Length: 105  Bit Score: 212.86  E-value: 1.25e-67
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502425  409 KTACRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVHLMNPEYVPKPCCAPTKLNAISV 488
Cdd:cd19398   1 RQVCKRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNHAILQSLVHLMKPEAVPKACCAPTKLSATSV 80

                        90       100
                ....*....|....*....|....*
gi 4502425  489 LYFDDNSNVILKKYRNMVVRACGCH 513
Cdd:cd19398  81 LYYDSNNNVILKKHRNMVVKSCGCH 105
TGFB smart00204
Transforming growth factor-beta (TGF-beta) family; Family members are active as ...
 412-513 5.76e-62

Transforming growth factor-beta (TGF-beta) family; Family members are active as disulphide-linked homo- or heterodimers. TGFB is a multifunctional peptide that controls proliferation, differentiation, and other functions in many cell types.


Pssm-ID: 214556  Cd Length: 102  Bit Score: 197.88  E-value: 5.76e-62
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502425     412 CRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVHLMNPEYVPKPCCAPTKLNAISVLYF 491
Cdd:smart00204   1 CRRRQLYVDFKDLGWDDWIIAPKGYNAYYCEGECPFPLSTSLNATNHAIVQTLVHLLGPNPVPKPCCVPTKLSPLSMLYY 80

                           90       100
                   ....*....|....*....|..
gi 4502425     492 DDNSNVILKKYRNMVVRACGCH 513
Cdd:smart00204  81 DDDGNVVLRNYPNMVVEECGCR 102
TGF_beta pfam00019
Transforming growth factor beta like domain;
412-512 5.93e-59

Transforming growth factor beta like domain;


Pssm-ID: 459632  Cd Length: 102  Bit Score: 189.84  E-value: 5.93e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502425    412 CRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVHLMNPEYVPKPCCAPTKLNAISVLYF 491
Cdd:pfam00019   2 CRRHSLYVDFEDLGWDDWIIAPKGYNAYYCSGSCPSHLNPQLSATNHAILQSLLHSLKPANVPKPCCVPTKLSPLSVLYY 81

                          90       100
                  ....*....|....*....|.
gi 4502425    492 DDNSNVILKKYRNMVVRACGC 512
Cdd:pfam00019  82 DDEGNVVLKTYPDMVVESCGC 102
TGF_beta_univin cd19387
transforming growth factor beta (TGF-beta) like domain found in Strongylocentrotus purpuratus ...
 410-513 8.13e-56

transforming growth factor beta (TGF-beta) like domain found in Strongylocentrotus purpuratus univin and similar proteins; Univin may have a critical role in early developmental decisions in the sea urchin embryo.


Pssm-ID: 381657  Cd Length: 104  Bit Score: 181.93  E-value: 8.13e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502425  410 TACRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVHLMNPEYVPKPCCAPTKLNAISVL 489
Cdd:cd19387   1 NICQRHSLYVDFKDVGWSDWIIAPRGYQAYRCAGECPFPLNEHLNGTNHAIIQTLVNSIDPSNVPKACCAPTKLSSISML 80

                        90       100
                ....*....|....*....|....
gi 4502425  490 YFDDNSNVILKKYRNMVVRACGCH 513
Cdd:cd19387  81 YFDNNDNVVLRQYEDMVVEACGCR 104
TGF_beta_GDF1_3_like cd13764
transforming growth factor beta (TGF-beta) like domain found in embryonic growth ...
 412-512 1.86e-52

transforming growth factor beta (TGF-beta) like domain found in embryonic growth/differentiation factor 1 (GDF1), factor 3 (GDF3) and similar proteins; The family includes GDF-1 and GDF-3. GDF1 may mediate cell differentiation events during embryonic development. GDF3 is a growth factor involved in early embryonic development and adipose-tissue homeostasis. The family also contains protein DVR-1, also termed vegetal hemisphere VG1 protein (VG-1), which serves to facilitate the differentiation of either mesoderm or endoderm either as a cofactor in an instructive signal or by providing permissive environment.


Pssm-ID: 381642  Cd Length: 102  Bit Score: 173.04  E-value: 1.86e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502425  412 CRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVHLMNPEYVPKPCCAPTKLNAISVLYF 491
Cdd:cd13764   1 CKKRRLYISFRDVGWQNWIIAPQGYMANYCHGECPFPLTESLNGTNHAILQTLVHSVDPEGTPQPCCVPTRLSPISMLYY 80

                        90       100
                ....*....|....*....|.
gi 4502425  492 DDNSNVILKKYRNMVVRACGC 512
Cdd:cd13764  81 DNNDNVVLRHYEDMVVDECGC 101
TGF_beta_BMPs_GDFs cd13756
transforming growth factor beta (TGF-beta) like domain found in the BMP/GDF family; The BMP ...
 412-512 3.68e-52

transforming growth factor beta (TGF-beta) like domain found in the BMP/GDF family; The BMP/GDF family consists of bone morphogenetic proteins (BMPs), growth and differentiation factors (GDFs) and similar proteins. BMPs are a group of growth factors also known as cytokines and as metabologens. They induce the formation of bone and cartilage and functions as pivotal morphogenetic signals, orchestrating tissue architecture throughout the body. GDFs have functions predominantly in development.


Pssm-ID: 381634  Cd Length: 102  Bit Score: 172.12  E-value: 3.68e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502425  412 CRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVHLMNP-EYVPKPCCAPTKLNAISVLY 490
Cdd:cd13756   1 CRRRPLYVDFSDLGWDDWIIAPKGYNANYCAGSCPFPLSSHANATNHAILQALLHSLNPkKSVPKPCCVPTKYSPLSVLY 80

                        90       100
                ....*....|....*....|..
gi 4502425  491 FDDNSNVILKKYRNMVVRACGC 512
Cdd:cd13756  81 YDEDGNVVLKTYPDMVVEECGC 102
TGF_beta_BMP2_like cd13760
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 2 ...
 412-513 7.68e-52

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 2 (BMP-2), 4 (BMP-4) and similar proteins; The family includes BMP2 and BMP4 (also known as BMP2B), both of which induce cartilage and bone formation. BMP-2 stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP-4 acts in mesoderm induction, tooth development, limb formation and fracture repair.


Pssm-ID: 381638  Cd Length: 102  Bit Score: 171.52  E-value: 7.68e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502425  412 CRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVHLMNPEYVPKPCCAPTKLNAISVLYF 491
Cdd:cd13760   1 CRRHSLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAIVQTLVNSVNPGAVPKACCVPTELSPISMLYL 80

                        90       100
                ....*....|....*....|..
gi 4502425  492 DDNSNVILKKYRNMVVRACGCH 513
Cdd:cd13760  81 DEYDKVVLKNYQDMVVEGCGCR 102
TGF_beta_BMP2 cd19390
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 2 ...
 410-512 3.53e-51

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 2 (BMP-2) and similar proteins; BMP-2, also termed BMP-2A, induces cartilage and bone formation. It stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway.


Pssm-ID: 381660  Cd Length: 103  Bit Score: 169.78  E-value: 3.53e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502425  410 TACRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVHLMNPEyVPKPCCAPTKLNAISVL 489
Cdd:cd19390   1 SSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAIVQTLVNSVNSK-IPKACCVPTELSAISML 79

                        90       100
                ....*....|....*....|...
gi 4502425  490 YFDDNSNVILKKYRNMVVRACGC 512
Cdd:cd19390  80 YLDENEKVVLKNYQDMVVEGCGC 102
TGF_beta_ADMP cd13765
transforming growth factor beta (TGF-beta) like domain found in anti-dorsalizing morphogenetic ...
 410-513 6.23e-51

transforming growth factor beta (TGF-beta) like domain found in anti-dorsalizing morphogenetic protein (ADMP) and similar proteins; ADMP is a bone morphogenetic protein (BMP)-like transforming growth factor beta ligand, functions in the trunk organizer to antagonize head formation, thereby regulating organizer patterning. It negatively affects the formation of the organizer, although it is robustly expressed within the organizer itself. The organizer-promoting signal of ADMP is mediated by the activin A type I receptor, ACVR1 (also known as activin receptor-like kinase-2, ALK2).


Pssm-ID: 381643  Cd Length: 105  Bit Score: 169.07  E-value: 6.23e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502425  410 TACRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVHLMN-PEYVPKPCCAPTKLNAISV 488
Cdd:cd13765   1 RSCQRHELYVDFEEIGWSGWIISPKGYNAYHCKGSCPFPLGQNQKPTNHATVQSIVHALKlAKGVEMPCCVPDKLYSISL 80

                        90       100
                ....*....|....*....|....*
gi 4502425  489 LYFDDNSNVILKKYRNMVVRACGCH 513
Cdd:cd13765  81 LYFDDDENVVLKQYDDMVAASCGCH 105
TGF_beta_BMP9_like cd13767
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic proteins, ...
 412-513 1.76e-49

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic proteins, BMP-9, BMP-10 and similar proteins; The family includes BMP9 (also known as GDF2) and BMP10. BMP-9 is a potent circulating inhibitor of angiogenesis. It signals through the type I activin receptor ACVRL1 but not other activin receptor-like kinases (ALKs). BMP-10 is required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. It inhibits endothelial cell migration and growth. It may reduce cell migration and cell matrix adhesion in breast cancer cell lines.


Pssm-ID: 381645  Cd Length: 105  Bit Score: 165.23  E-value: 1.76e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502425  412 CRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVHLMNPEYVPKPCCAPTKLNAISVLYF 491
Cdd:cd13767   3 CRRKPLYVNFADIGWDSWIIAPKGYEAYECSGKCFFPLADHLSPTKHAIIQTLVHSKSPEKVSRACCVPTKLEPISLLYI 82

                        90       100
                ....*....|....*....|...
gi 4502425  492 DDNSNVILK-KYRNMVVRACGCH 513
Cdd:cd13767  83 DENGVLTYKyKYEGMVVAECGCR 105
TGF_beta_DPP cd19392
transforming growth factor beta (TGF-beta) like domain found in Drosophila melanogaster ...
 409-512 6.99e-49

transforming growth factor beta (TGF-beta) like domain found in Drosophila melanogaster protein decapentaplegic (Dpp) and similar proteins; decapentaplegic (Dpp) and similar proteins Dpp, also termed as protein DPP-C, is required later in embryogenesis for dorsal closure and patterning of the hindgut. It also functions postembryonically as a long-range morphogen during imaginal disk development and is responsible for the progression of the morphogenetic furrow during eye development.


Pssm-ID: 381662  Cd Length: 109  Bit Score: 163.85  E-value: 6.99e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502425  409 KTACRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVHLMNPEYVPKPCCAPTKLNAISV 488
Cdd:cd19392   5 QNLCRRHPLYVDFSDVGWDDWIVAPLGYDAYYCNGECPFPLADYLNATNHAVVQTLVNSVDPQAVPKACCVPTELSSIAM 84

                        90       100
                ....*....|....*....|....
gi 4502425  489 LYFDDNSNVILKKYRNMVVRACGC 512
Cdd:cd19392  85 LYVDEHDKVVLKNYQDMVVEGCGC 108
TGF_beta_GDF5_6_7 cd13766
transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor ...
 412-512 4.95e-48

transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor 5 (GDF5), factor 6 (GDF6), factor 7 (GDF7) and similar proteins; The family includes GDF5, GDF6 and GDF7. GDF5, also termed bone morphogenetic protein 14 (BMP-14), or cartilage-derived morphogenetic protein 1 (CDMP-1), or lipopolysaccharide-associated protein 4 (LAP-4), or LPS-associated protein 4, or radotermin, is a growth factor involved in bone and cartilage formation. GDF6, also termed bone morphogenetic protein 13 (BMP-13), or growth/differentiation factor 16, is a growth factor that controls proliferation and cellular differentiation in the retina and bone formation. GDF7, also termed bone morphogenetic protein 12 (BMP-12), may play an active role in the motor area of the primate neocortex.


Pssm-ID: 381644  Cd Length: 102  Bit Score: 161.45  E-value: 4.95e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502425  412 CRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVHLMNPEYVPKPCCAPTKLNAISVLYF 491
Cdd:cd13766   1 CSRKPLHVNFKDLGWDDWIIAPLDYEAYHCEGVCDFPLRSHLEPTNHAIIQTLMNSMDPESTPPSCCVPTKLSPISILYI 80

                        90       100
                ....*....|....*....|.
gi 4502425  492 DDNSNVILKKYRNMVVRACGC 512
Cdd:cd13766  81 DSANNVVYKQYEDMVVESCGC 101
TGF_beta_BMP3_like cd13763
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 3 ...
 412-512 3.20e-44

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 3 (BMP-3), growth/differentiation factor 10 (GDF10) and similar proteins; The family includes BMP-3 (also known as BMP-3A or osteogenin) and GDF10 (also known as BMP-3B). BMP-3 negatively regulates bone density. It antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossification. GDF10 is a growth factor involved in osteogenesis and adipogenesis.


Pssm-ID: 381641  Cd Length: 103  Bit Score: 151.36  E-value: 3.20e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502425  412 CRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVH--LMNPEyVPKPCCAPTKLNAISVL 489
Cdd:cd13763   1 CSRRPLTVDFADIGWSDWIISPKSFDAYYCAGSCPFPLTKELRPSNHATIQSIVHavGIQPG-VPAPCCVPDKMSSLTLL 79

                        90       100
                ....*....|....*....|...
gi 4502425  490 YFDDNSNVILKKYRNMVVRACGC 512
Cdd:cd13763  80 YFDENRNVVLKNYPNMTVESCAC 102
TGF_beta_BMP4_BMP2B cd19391
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 4 ...
 409-513 5.14e-44

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 4 (BMP-4) and similar proteins; BMP-4, also termed BMP-2B, induces cartilage and bone formation. It also acts in mesoderm induction, tooth development, limb formation and fracture repair.


Pssm-ID: 381661  Cd Length: 107  Bit Score: 150.97  E-value: 5.14e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502425  409 KTACRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVHLMNPEyVPKPCCAPTKLNAISV 488
Cdd:cd19391   4 NKNCRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTLVNSVNSS-IPKACCVPTELSAISM 82

                        90       100
                ....*....|....*....|....*
gi 4502425  489 LYFDDNSNVILKKYRNMVVRACGCH 513
Cdd:cd19391  83 LYLDEYDKVVLKNYQEMVVEGCGCR 107
TGF_beta_GDF5 cd19399
transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor ...
 412-512 1.13e-40

transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor 5 (GDF5) and similar proteins; GDF5, also termed bone morphogenetic protein 14 (BMP-14), or cartilage-derived morphogenetic protein 1 (CDMP-1), or lipopolysaccharide-associated protein 4 (LAP-4), or LPS-associated protein 4, or radotermin, is a growth factor involved in bone and cartilage formation.


Pssm-ID: 381669  Cd Length: 103  Bit Score: 142.07  E-value: 1.13e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502425  412 CRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVHLMNPEYVPKPCCAPTKLNAISVLYF 491
Cdd:cd19399   2 CSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISILFI 81

                        90       100
                ....*....|....*....|.
gi 4502425  492 DDNSNVILKKYRNMVVRACGC 512
Cdd:cd19399  82 DSANNVVYKQYEDMVVESCGC 102
TGF_beta_INHB cd13752
transforming growth factor beta (TGF-beta) like domain found in inhibin beta A chain (INHBA), ...
 412-512 3.15e-39

transforming growth factor beta (TGF-beta) like domain found in inhibin beta A chain (INHBA), B chain (INHBB), C chain (INHBC), E chain (INHBE) and similar proteins; The family includes inhibin beta A chain (INHBA), B chain (INHBB), C chain (INHBC), and E chain (INHBE). INHBA, also termed activin beta-A chain, or erythroid differentiation protein (EDF), is a component of inhibin A, activin A, or activin AB. Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. INHBB, also termed activin beta-B chain, is a component of inhibin B, activin A, or activin AB. Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. INHBC, also termed activin beta-C chain, might play important roles in carcinogenesis. It may function as a negative regulator of liver growth. INHBE, also termed activin beta-E chain, is a possible insulin resistance-associated hepatokine with hepatic gene expression that positively correlated with insulin resistance and body mass index in humans. It also acts as a possible new marker for drug-induced endoplasmic reticulum stress.


Pssm-ID: 381630  Cd Length: 100  Bit Score: 137.78  E-value: 3.15e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502425  412 CRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSfplNAHMNATNH--AIVQTLVHLMNPEYVPKPCCAPTKLNAISVL 489
Cdd:cd13752   1 CCRESFYVSFTDIGWDDWIIAPSGYYANYCKGSCS---GSSSPFRSHhtTILQKYLSKNKAKSELTPCCTPTKMSPLSLL 77

                        90       100
                ....*....|....*....|...
gi 4502425  490 YFDDNSNVILKKYRNMVVRACGC 512
Cdd:cd13752  78 YYDSDGNIVKKDLPNMIVESCGC 100
TGF_beta_GDP9_9B_like cd13762
transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor ...
 412-512 9.07e-39

transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor 9 (GDF-9), growth/differentiation factor 9B (GDF-9B) and similar proteins; The family includes GDF-9B (also known as BMP15) and GDF9. GDF-9B acts as oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth. GDF-9 is required for ovarian folliculogenesis. It promotes primordial follicle development and stimulates granulosa cell proliferation.


Pssm-ID: 381640  Cd Length: 104  Bit Score: 136.81  E-value: 9.07e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502425  412 CRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVHLMNPEYVPKPCCAPTKLNAISVLYF 491
Cdd:cd13762   3 CRRHRLRVRFRDLKWNGWIIAPTRYTANYCKGTCPRVLGQDLNPTNHAIVQNILHHLLDKSVPRPSCVPTELHPLSVLYY 82

                        90       100
                ....*....|....*....|.
gi 4502425  492 DDNSNVILKKYRNMVVRACGC 512
Cdd:cd13762  83 EEDGSIIYKEYPDMVASSCGC 103
TGF_beta_BMP10 cd19401
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 10 ...
 412-512 1.86e-38

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 10 (BMP-10) and similar proteins; BMP-10 is required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. It inhibits endothelial cell migration and growth. It may reduce cell migration and cell matrix adhesion in breast cancer cell lines.


Pssm-ID: 381671  Cd Length: 105  Bit Score: 136.14  E-value: 1.86e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502425  412 CRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVHLMNPEYVPKPCCAPTKLNAISVLYF 491
Cdd:cd19401   3 CKRSPLYVDFKEIGWDSWIIAPTGYEAYECRGVCYYPLTEHVTPTKHAIVQTLVHLKNPQKASKACCVPTKLDPISILYL 82

                        90       100
                ....*....|....*....|..
gi 4502425  492 DDNSNVILK-KYRNMVVRACGC 512
Cdd:cd19401  83 DDAGVVTYKfKYEGMVVAECGC 104
TGF_beta_NODAL cd13759
transforming growth factor beta (TGF-beta) like domain found in Nodal (NODAL)-related proteins; ...
 410-513 5.79e-36

transforming growth factor beta (TGF-beta) like domain found in Nodal (NODAL)-related proteins; NODAL is essential for mesoderm formation and axial patterning during embryonic development.


Pssm-ID: 381637  Cd Length: 103  Bit Score: 129.35  E-value: 5.79e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502425  410 TACRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVHLMNPEYVPKPCCAPTKLNAISVL 489
Cdd:cd13759   1 SLCRRVDFYVDFDRIGWGSWIVYPKKYNAYRCEGECPSPVDEDFKPTNHAYMQSLLKLYQPDRVPLPCCVPTKLSPLSML 80

                        90       100
                ....*....|....*....|....
gi 4502425  490 YFDDNsNVILKKYRNMVVRACGCH 513
Cdd:cd13759  81 YYEHG-EVVVRHHEDMIVEECGCR 103
TGF_beta_BMP9 cd19400
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 9 ...
 412-512 8.34e-36

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 9 (BMP-9) and similar proteins; BMP-9, also termed growth/differentiation factor 2 (GDF-2), is a potent circulating inhibitor of angiogenesis. It signals through the type I activin receptor ACVRL1 but not other activin receptor-like kinases (ALKs).


Pssm-ID: 381670  Cd Length: 105  Bit Score: 128.85  E-value: 8.34e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502425  412 CRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVHLMNPEYVPKPCCAPTKLNAISVLYF 491
Cdd:cd19400   3 CRKTSLRVNFKDIGWDSWIIAPKEYDAYECKGGCYFPLTDDVTPTKHAIIQTLVHLKNPKKAGKACCVPTKLDPISVLYK 82

                        90       100
                ....*....|....*....|..
gi 4502425  492 DDNSNVILK-KYRNMVVRACGC 512
Cdd:cd19400  83 DDMGVPTLKyHYEGMKVAECGC 104
TGF_beta_GDF8_like cd13751
transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factors, ...
 412-512 4.81e-35

transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factors, GDF8 and GDF11, and similar proteins; The family includes GDF8 and GDF11. GDF8, also termed myostatin, acts specifically as a negative regulator of skeletal muscle growth. GDF11, also termed bone morphogenetic protein 11 (BMP-11), is a secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development.


Pssm-ID: 381629  Cd Length: 96  Bit Score: 126.23  E-value: 4.81e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502425  412 CRkHELYVSFQDLGWqDWIIAPKGYAANYCDGECSF---PLNAHMNatnhaivqtLVHLMNPEYVPKPCCAPTKLNAISV 488
Cdd:cd13751   4 CR-YPLTVDFEEFGW-DWIIAPKTYDANYCSGECPFvylQSYPHTH---------LVQQANPRGSAGPCCTPTKMSPLSM 72

                        90       100
                ....*....|....*....|....
gi 4502425  489 LYFDDNSNVILKKYRNMVVRACGC 512
Cdd:cd13751  73 LYFDEDGNIIYGTLPDMVVERCGC 96
TGF_beta_GDF15 cd19376
transforming growth factor beta (TGF-beta) like domain found in mammalian growth ...
 412-512 5.92e-34

transforming growth factor beta (TGF-beta) like domain found in mammalian growth/differentiation factor 15 (GDF-15) and similar proteins; GDF-15, also termed macrophage inhibitory cytokine 1 (MIC-1), or NSAID-activated gene 1 protein (NAG-1), or NSAID-regulated gene 1 protein (NRG-1), or placental TGF-beta, or placental bone morphogenetic protein, or prostate differentiation factor, regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses.


Pssm-ID: 381646  Cd Length: 101  Bit Score: 123.58  E-value: 5.92e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502425  412 CRKHeLYVSFQDLGWQDWIIAPKGYAANYCDGECsfPLNAHMnATNHAIVQTLVHLMNPEYVPKPCCAPTKLNAISVLYF 491
Cdd:cd19376   4 CRFS-LRVSFKEIGWADWVLAPESYNAYYCDGSC--PHNYKP-ANMHAQIKSRLHRLNPGAVPAPCCVPSSYEPLTLLHY 79

                        90       100
                ....*....|....*....|.
gi 4502425  492 DDNSNVILKKYRNMVVRACGC 512
Cdd:cd19376  80 DSDGKLTLTEFDDMIVKDCHC 100
TGF_beta_BMP3 cd19393
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 3 ...
 412-512 3.00e-32

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 3 (BMP-3) and similar proteins; BMP-3, also termed BMP-3A, or osteogenin, negatively regulates bone density. It antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossification.


Pssm-ID: 381663  Cd Length: 110  Bit Score: 119.37  E-value: 3.00e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502425  412 CRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVHLMN--PEyVPKPCCAPTKLNAISVL 489
Cdd:cd19393   8 CARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPSNHATIQSIVRAVGvvPG-IPEPCCVPEKMSSLSIL 86

                        90       100
                ....*....|....*....|...
gi 4502425  490 YFDDNSNVILKKYRNMVVRACGC 512
Cdd:cd19393  87 FFDENKNVVLKVYPNMTVESCAC 109
TGF_beta_SF cd08698
transforming growth factor beta (TGF-beta) like domain found in TGF-beta superfamily; TGF-beta ...
 412-512 7.68e-32

transforming growth factor beta (TGF-beta) like domain found in TGF-beta superfamily; TGF-beta superfamily consists of a large group of cell regulatory proteins, such as TFG-betas, Nodal, Activins/Inhibins, glial cell-line-derived neurotrophic factor (GDNF) family of ligands, bone morphogenetic proteins (BMPs), and growth and differentiation factors (GDFs). They play important roles in developmental and physiological processes in a variety of species, including invertebrates as well as vertebrates, through specific receptor complexes that are composed of type I and type II serine/threonine receptor kinases. The receptor kinases subsequently activate Smad proteins, which then propagate the signals into the nucleus to regulate target gene expression. Proteins from the TGF-beta superfamily are only active as homo- or heterodimer.


Pssm-ID: 381627  Cd Length: 100  Bit Score: 117.96  E-value: 7.68e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502425  412 CRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAHMNATnHAIVQTLVHLMNPEYVPKPCCAPTKLNAISVLYF 491
Cdd:cd08698   1 CCKQPLYVNFKDLGGLNWIIAPSGFTANYCRGSCNSESSATTNHT-KLLQWSRTRRHTPREELKPCCVPTSYEPLSILYY 79

                        90       100
                ....*....|....*....|.
gi 4502425  492 DDNSNVILKKYRNMVVRACGC 512
Cdd:cd08698  80 DNNGTVVETLLPNLIVTECGC 100
TGF_beta_GDF10 cd19394
transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor ...
 410-512 2.93e-30

transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor 10 (GDF10) and similar proteins; GDF10, also termed bone morphogenetic protein 3B (BMP-3B), or bone-inducing protein (BIP), is a growth factor involved in osteogenesis and adipogenesis.


Pssm-ID: 381664  Cd Length: 112  Bit Score: 113.85  E-value: 2.93e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502425  410 TACRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVHLMN--PEyVPKPCCAPTKLNAIS 487
Cdd:cd19394   8 RVCSRRYLKVDFADIGWSEWIISPKSFDAYYCAGACEFPMPKVVRPSNHATIQSIVKAVGiiPG-VPEPCCVPDKMNSLS 86

                        90       100
                ....*....|....*....|....*
gi 4502425  488 VLYFDDNSNVILKKYRNMVVRACGC 512
Cdd:cd19394  87 VLFLDENRNVVLKVYPNMSVETCAC 111
TGF_beta_GDF9B cd19402
transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor ...
 412-512 8.07e-29

transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor 9B (GDF-9B) and similar proteins; GDF-9B, also termed bone morphogenetic protein 15 (BMP15), acts as oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth.


Pssm-ID: 381672  Cd Length: 104  Bit Score: 109.90  E-value: 8.07e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502425  412 CRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVHLMNPEYVPKPCCAPTKLNAISVLYF 491
Cdd:cd19402   3 CSLHSFWVSFHQLGWDHWIIAPHRYNPGYCKGDCPRILHYGYNSPNHAIVQNFINQLVDANVPRPSCVPYKYGPISVLMI 82

                        90       100
                ....*....|....*....|.
gi 4502425  492 DDNSNVILKKYRNMVVRACGC 512
Cdd:cd19402  83 EPNGNILYKEYEDMIAESCTC 103
TGF_beta_TGFbeta1_2_3 cd13753
transforming growth factor beta (TGF-beta) like domain found in transforming growth factor ...
 412-512 1.11e-28

transforming growth factor beta (TGF-beta) like domain found in transforming growth factor beta-1 (TGF-beta-1), beta-2 (TGF-beta-2), beta-3 (TGF-beta-3) and similar proteins; The family includes TGF-beta-1, TGF-beta-2 and TGF-beta-3, which are polypeptide members of the transforming growth factor beta superfamily of cytokines. TGF-beta-1 is a secreted protein that performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation, and apoptosis. TGF-beta-2 is a secreted protein that performs many cellular functions and has a vital role during embryonic development. It can suppress the effects of interleukin-2 dependent T-cell growth. TGF-beta-3 is involved in embryogenesis and cell differentiation. It regulates molecules involved in cellular adhesion and extracellular matrix (ECM) formation during the process of palate development.


Pssm-ID: 381631  Cd Length: 97  Bit Score: 108.93  E-value: 1.11e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502425  412 CRKHELYVSFQ-DLGWqDWIIAPKGYAANYCDGECSFPLNAhmnATNHAIVQTLVHLMNPEYVPKPCCAPTKLNAISVLY 490
Cdd:cd13753   1 CCLRPLYINFRrDLGW-KWIHEPKGFNANYCAGACPYLWSA---DTQHSTVLQLYNRLNPVASAAPCCSPRELEPLTILY 76

                        90       100
                ....*....|....*....|..
gi 4502425  491 FdDNSNVILKKYRNMVVRACGC 512
Cdd:cd13753  77 Y-DGRNPKIETLSNMIVTSCKC 97
TGF_beta_GDF8 cd19388
transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor ...
 402-512 1.81e-28

transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor 8 (GDF8) and similar proteins; GDF8, also termed myostatin, acts specifically as a negative regulator of skeletal muscle growth.


Pssm-ID: 381658  Cd Length: 108  Bit Score: 108.97  E-value: 1.81e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502425  402 DYNSSElkTACRKHELYVSFQDLGWqDWIIAPKGYAANYCDGECSFPLNAHMNATNhaivqtLVHLMNPEYVPKPCCAPT 481
Cdd:cd19388   6 DEHSTE--SRCCRYPLTVDFEAFGW-DWIIAPKRYKANYCSGECEFVFLQKYPHTH------LVHQANPRGSAGPCCTPT 76

                        90       100       110
                ....*....|....*....|....*....|.
gi 4502425  482 KLNAISVLYFDDNSNVILKKYRNMVVRACGC 512
Cdd:cd19388  77 KMSPINMLYFNGKEQIIYGKIPAMVVDRCGC 107
TGF_beta_INHBA cd19404
transforming growth factor beta (TGF-beta) like domain found in inhibin beta A chain (INHBA) ...
 412-512 2.53e-28

transforming growth factor beta (TGF-beta) like domain found in inhibin beta A chain (INHBA) and similar proteins; INHBA, also termed activin beta-A chain, or erythroid differentiation protein (EDF), is a component of inhibin A, activin A, or activin AB. Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland.


Pssm-ID: 381674  Cd Length: 108  Bit Score: 108.47  E-value: 2.53e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502425  412 CRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSfplnAHMNATN------HAIVqtLVHLMNPEYVP----KPCCAPT 481
Cdd:cd19404   3 CCKKQFYVSFKDIGWSDWIIAPSGYHANYCEGECP----SHIAGTSgsslsfHSTV--INHYRMRGYSPfanlKSCCVPT 76

                        90       100       110
                ....*....|....*....|....*....|.
gi 4502425  482 KLNAISVLYFDDNSNVILKKYRNMVVRACGC 512
Cdd:cd19404  77 KLRAMSMLYYDDGQNIIKKDIQNMIVEECGC 107
TGF_beta_maverick cd13755
transforming growth factor beta (TGF-beta) like domain found in Drosophila melanogaster ...
 409-512 1.05e-26

transforming growth factor beta (TGF-beta) like domain found in Drosophila melanogaster maverick and similar proteins; Maverick, also termed MAV, is a novel member of the TGF-beta superfamily in Drosophila. It's a bone morphogenetic protein (BMP)/TGF-beta related ligand.


Pssm-ID: 381633  Cd Length: 102  Bit Score: 103.93  E-value: 1.05e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502425  409 KTACRkHELYVSFQDLGWQDWIIAPKGYAANYCDGECSfplNAHMNATNHAIVQTLVHLMNPEyVPKPCCAPTKLNAISV 488
Cdd:cd13755   2 KKCCR-HSLKVDFKKLPGFEWIIQPKEFDAGYCKGRCP---PRYNYANNHALIQSLLRRMKKK-VPRPCCAPSKLESLEV 76

                        90       100
                ....*....|....*....|....*.
gi 4502425  489 LYFDDNSNVILK--KYRNMVVRACGC 512
Cdd:cd13755  77 LHYDESDSSKLKvtKWKGMIVSECAC 102
TGF_beta_INHA_B_like cd19377
transforming growth factor beta (TGF-beta) like domain found in inhibin alpha chain (INHA), ...
 412-512 1.47e-26

transforming growth factor beta (TGF-beta) like domain found in inhibin alpha chain (INHA), beta chain (INHB) and similar proteins; INHA is a component of inhibins (inhibin A or inhibin B) that inhibit the secretion of follitropin by the pituitary gland. INHB includes inhibin beta A chain (INHBA), B chain (INHBB), C chain (INHBC), and E chain (INHBE). INHBA, also termed activin beta-A chain, or erythroid differentiation protein (EDF), is a component of inhibin A, activin A, or activin AB. Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. INHBB, also termed activin beta-B chain, is a component of inhibin B, activin A, or activin AB. Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. INHBC, also termed activin beta-C chain, might play important roles in carcinogenesis. It may function as a negative regulator of liver growth. INHBE, also termed activin beta-E chain, is a possible insulin resistance-associated hepatokine with hepatic gene expression that positively correlated with insulin resistance and body mass index in humans. It also acts as a possible new marker for drug-induced endoplasmic reticulum stress.


Pssm-ID: 381647  Cd Length: 101  Bit Score: 103.32  E-value: 1.47e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502425  412 CRKHELYVSFQDLGWQDWIIAPKGYAANYCDGEC--SFPLNAHMNATNHAIVQTLVHLMNPEyvPKPCCAPTKLNAISVL 489
Cdd:cd19377   1 CCRVALFVSFEELGWNRWIIAPPGFNFHFCHGGCalHIVPDLSLPVPSAPPTPARPYSVLPG--AQPCCAPTKVTPLSVL 78

                        90       100
                ....*....|....*....|...
gi 4502425  490 YFDDNSNVILKKYRNMVVRACGC 512
Cdd:cd19377  79 YTSDGGTIKYETIPDLIVQECGC 101
TGF_beta_INHBC_E cd19406
transforming growth factor beta (TGF-beta) like domain found in inhibin beta C chain (INHBC), ...
 412-512 1.49e-26

transforming growth factor beta (TGF-beta) like domain found in inhibin beta C chain (INHBC), inhibin beta E chain (INHBE) and similar proteins; The family includes INHBC and INHBE. INHBC, also termed activin beta-C chain, might play important roles in carcinogenesis. It may function as a negative regulator of liver growth. INHBE, also termed activin beta-E chain, is a possible insulin resistance-associated hepatokine with hepatic gene expression that positively correlated with insulin resistance and body mass index in humans. It also acts as a possible new marker for drug-induced endoplasmic reticulum stress.


Pssm-ID: 381676  Cd Length: 104  Bit Score: 103.31  E-value: 1.49e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502425  412 CRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAH--MNATNHAIVQTLVHLMNPEYVPKPCCAPTKLNAISVL 489
Cdd:cd19406   1 CCRRDFYVDFKDIGWNDWIIKPEGYQMNYCMGQCPLHIAGSpgIAASFHTAVLNLVKANNIATAVHSCCVPTARRPLSLL 80

                        90       100
                ....*....|....*....|...
gi 4502425  490 YFDDNSNVILKKYRNMVVRACGC 512
Cdd:cd19406  81 YFDRNSNIVKTDIPDMIVEACGC 103
TGF_beta_INHBB cd19405
transforming growth factor beta (TGF-beta) like domain found in inhibin beta B chain (INHBB) ...
 412-512 2.12e-25

transforming growth factor beta (TGF-beta) like domain found in inhibin beta B chain (INHBB) and similar proteins; INHBB, also termed activin beta-B chain, is a component of inhibin B, activin A, or activin AB. Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland.


Pssm-ID: 381675  Cd Length: 107  Bit Score: 100.39  E-value: 2.12e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502425  412 CRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSfplnAHM------NATNHAIV--QTLVHLMNPEYVpKPCCAPTKL 483
Cdd:cd19405   3 CCRQQFYIDFRLIGWNDWIIAPVGYYGNYCEGSCP----AYMagvpgsASSFHTAVvnQYRMRGMNPGTV-NSCCIPTKL 77

                        90       100
                ....*....|....*....|....*....
gi 4502425  484 NAISVLYFDDNSNVILKKYRNMVVRACGC 512
Cdd:cd19405  78 STMSMLYFDDEYNIVKRDVPNMIVEECGC 106
TGF_beta_DAF7 cd19378
transforming growth factor beta (TGF-beta) like domain found in Caenorhabditis elegans Dauer ...
 412-512 5.04e-22

transforming growth factor beta (TGF-beta) like domain found in Caenorhabditis elegans Dauer larva development regulatory growth factor DAF-7 and similar proteins; DAF-7, also termed abnormal dauer formation protein 7, may act as a negative regulator of dauer larva development by transducing chemosensory information from ASI neurons. It is involved in sensitivity to CO2 levels.


Pssm-ID: 381648  Cd Length: 100  Bit Score: 90.47  E-value: 5.04e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502425  412 CRKHELYVSFQDLGWqDWIIAPKGYAANYCDGECSfPLNAHMNATNH-AIVQTLVHLMNPEYvpKPCCAPTKLNAISVLY 490
Cdd:cd19378   3 CCLYDLTIDFEEIGW-NFIIAPKKYNANMCRGDCK-SNHHHRPNSASiLLNPITRSESKQEH--GSCCHPTEYDPITVVY 78

                        90       100
                ....*....|....*....|..
gi 4502425  491 FDDNSNVILKKYRNMVVRACGC 512
Cdd:cd19378  79 FNEDGQLKIKTINGMIAKKCSC 100
TGF_beta_GDF11 cd19389
transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor ...
 402-512 3.23e-21

transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor 11 (GDF11) and similar proteins; GDF11, also termed bone morphogenetic protein 11 (BMP-11), is a secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development.


Pssm-ID: 381659  Cd Length: 109  Bit Score: 88.55  E-value: 3.23e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502425  402 DYNSSElkTACRKHELYVSFQDLGWqDWIIAPKGYAANYCDGECSFPLNAHMNATNhaivqtLVHLMNPEYVPKPCCAPT 481
Cdd:cd19389   7 DEHSTE--SRCCRYPLTVDFEAFGW-DWIIAPKRYKANYCSGQCEYMFMQKYPHTH------LVQQANPRGSAGPCCTPT 77

                        90       100       110
                ....*....|....*....|....*....|.
gi 4502425  482 KLNAISVLYFDDNSNVILKKYRNMVVRACGC 512
Cdd:cd19389  78 KMSPINMLYFNDKQQIIYGKIPGMVVDRCGC 108
TGF_beta_GDF9 cd19403
transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor ...
 412-512 4.60e-19

transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor 9 (GDF-9) and similar proteins; GDF-9 is required for ovarian folliculogenesis. It promotes primordial follicle development and stimulates granulosa cell proliferation.


Pssm-ID: 381673  Cd Length: 106  Bit Score: 82.60  E-value: 4.60e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502425  412 CRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVHLMNPEYVPKPCCAPTKLNAISVLYF 491
Cdd:cd19403   5 CELHDFRLSFSQLKWDHWIIAPHRYNPRYCKGSCPRAVGHRYGSPVHTMVQNIIYEKLDSSIPRPSCVPSEYNPLSVLTI 84

                        90       100
                ....*....|....*....|.
gi 4502425  492 DDNSNVILKKYRNMVVRACGC 512
Cdd:cd19403  85 EPDGSIAYKEYEDMIATKCTC 105
TGF_beta_AMH cd13757
transforming growth factor beta (TGF-beta) like domain found in anti-Muellerian hormone (AMH) ...
 412-512 1.69e-18

transforming growth factor beta (TGF-beta) like domain found in anti-Muellerian hormone (AMH) and similar proteins; AMH, also termed Muellerian-inhibiting factor, or Muellerian-inhibiting substance (MIS), is a glycoprotein that causes regression of the Muellerian duct. It can also inhibit the growth of tumors derived from tissues of Muellerian duct origin.


Pssm-ID: 381635  Cd Length: 99  Bit Score: 80.49  E-value: 1.69e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502425  412 CRKHELYVsfqDLGWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVHLMNPEYVPKPCCAPTKLNAISVLYF 491
Cdd:cd13757   2 CRLRELSV---SLRSEKFILSPKRYNINNCQGPCRFPLSDRPRYNNHAVLLLKMQERGLPLQRAPCCVPVAYEELLVVEL 78

                        90       100
                ....*....|....*....|.
gi 4502425  492 DDNSnVILKKYRNMVVRACGC 512
Cdd:cd13757  79 SDEG-TEISLKPNMVATECGC 98
TGF_beta_TGFB3 cd19386
transforming growth factor beta (TGF-beta) like domain found in transforming growth factor ...
 412-512 1.80e-18

transforming growth factor beta (TGF-beta) like domain found in transforming growth factor beta-3 (TGF-beta-3) and similar proteins; TGF-beta-3 is a polypeptide member of the transforming growth factor beta superfamily of cytokines. It is involved in embryogenesis and cell differentiation. It regulates molecules involved in cellular adhesion and extracellular matrix (ECM) formation during the process of palate development.


Pssm-ID: 381656  Cd Length: 101  Bit Score: 80.45  E-value: 1.80e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502425  412 CRKHELYVSF-QDLGWQdWIIAPKGYAANYCDGECSFPLNAHmnaTNHAIVQTLVHLMNPEYVPKPCCAPTKLNAISVLY 490
Cdd:cd19386   4 CCVRPLYIDFrQDLGWK-WVHEPKGYFANFCSGPCPYLRSAD---TTHSTVLGLYNTLNPEASASPCCVPQDLEPLTILY 79

                        90       100
                ....*....|....*....|..
gi 4502425  491 FDDNSNVIlKKYRNMVVRACGC 512
Cdd:cd19386  80 YVGRTPKV-EQLSNMVVKSCKC 100
TGF_beta_TGFB2 cd19385
transforming growth factor beta (TGF-beta) like domain found in transforming growth factor ...
 412-512 2.98e-18

transforming growth factor beta (TGF-beta) like domain found in transforming growth factor beta-2 (TGF-beta-2) and similar proteins; TGF-beta-2, also termed BSC-1 cell growth inhibitor, or cetermin, or glioblastoma-derived T-cell suppressor factor (G-TSF), or polyergin, is a polypeptide member of the transforming growth factor beta superfamily of cytokines. It is a secreted protein that performs many cellular functions and has a vital role during embryonic development. It can suppress the effects of interleukin-2 dependent T-cell growth.


Pssm-ID: 381655  Cd Length: 97  Bit Score: 79.69  E-value: 2.98e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502425  412 CRKHELYVSFQ-DLGWQdWIIAPKGYAANYCDGECSFPLNAHmnaTNHAIVQTLVHLMNPEYVPKPCCAPTKLNAISVLY 490
Cdd:cd19385   1 CCLRPLYIDFKrDLGWK-WIHEPKGYNANFCAGACPYLWSSD---TQHSRVLSLYNTINPEASASPCCVSQDLEPLTILY 76

                        90       100
                ....*....|....*....|..
gi 4502425  491 FDDNSNVIlKKYRNMVVRACGC 512
Cdd:cd19385  77 YIGKTPKI-EQLSNMIVKSCKC 97
TGF_beta_TGFB1 cd19384
transforming growth factor beta (TGF-beta) like domain found in transforming growth factor ...
 412-512 1.11e-16

transforming growth factor beta (TGF-beta) like domain found in transforming growth factor beta-1 (TGF-beta-1) and similar proteins; TGF-beta-1 is a polypeptide member of the transforming growth factor beta superfamily of cytokines. It is a secreted protein that performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation, and apoptosis.


Pssm-ID: 381654  Cd Length: 99  Bit Score: 75.29  E-value: 1.11e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502425  412 CRKHELYVSF-QDLGWQdWIIAPKGYAANYCDGECSFPLNAHmnaTNHAIVQTLVHLMNPEYVPKPCCAPTKLNAISVLY 490
Cdd:cd19384   2 CCVRQLYIDFrKDLGWK-WIHEPKGYHANFCLGPCPYIWSLD---TQYSKVLALYNQHNPGASAAPCCVPQALEPLPIVY 77

                        90       100
                ....*....|....*....|..
gi 4502425  491 FdDNSNVILKKYRNMVVRACGC 512
Cdd:cd19384  78 Y-VGRKPKVEQLSNMIVRSCKC 98
TGF_beta_LEFTY1_2 cd13758
transforming growth factor beta (TGF-beta) like domain found in left-right determination ...
 410-512 2.37e-10

transforming growth factor beta (TGF-beta) like domain found in left-right determination factor 1 (lefty-1), factor 2 (lefty-2) and similar proteins; Lefty-1, also termed left-right determination factor B, or protein lefty-B, is required for left-right axis determination as a regulator of Lefty-2 and NODAL. Lefty-2, also termed endometrial bleeding-associated factor, or left-right determination factor A, or protein lefty-A, or transforming growth factor beta-4 (TGF-beta-4), is required for left-right (L-R) asymmetry determination of organ systems in mammals. It may play a role in endometrial bleeding.


Pssm-ID: 381636  Cd Length: 90  Bit Score: 56.99  E-value: 2.37e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502425  410 TACRKhELYVSFQDLGW-QDWIIAPKGYAANYCDGECSFPLNAHMNatnhaivqtlvhlmnPEYVPkPCCAPTKLNAISV 488
Cdd:cd13758   1 TCCRQ-EYYIDFRELTWtDYWIIEPPGYQAYECVGGCPQPPPPLAW---------------PSLGH-RQCGVSESASLPM 63

                        90       100
                ....*....|....*....|....*..
gi 4502425  489 LYF---DDNSNVILKKYRNMVVRACGC 512
Cdd:cd13758  64 MYLvkkGDYTEVEVAEFPNMIVEKCGC 90
TGF_beta_GSDF cd19379
transforming growth factor beta (TGF-beta) like domain found in Danio rerio gonadal somatic ...
 418-512 3.78e-10

transforming growth factor beta (TGF-beta) like domain found in Danio rerio gonadal somatic cell derived factor (GSDF) and similar proteins; GSDF is a new member of transforming growth factor beta (TGF-beta) superfamily. It is a teleost- and gonad-specific growth factor that controls sex determination in some fish and plays an important role in mediating germ cell/soma signaling.


Pssm-ID: 381649  Cd Length: 94  Bit Score: 56.60  E-value: 3.78e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502425  418 YVSFQDLGWQDWIIAPKGYAANYCDGeCsfplNAHMNATNHAIVQTLVHLmnPEYVPKPCCAPTKLNAISVLYFDDNSNV 497
Cdd:cd19379   9 EIFFKDLGWENWVIYPESFTYVQCVG-C----NAGRNSSESQCRQRLQGR--AGARQERCCKPTSQEAVPFVYIDEDSSL 81

                        90
                ....*....|....*
gi 4502425  498 ILKKyrNMVVRACGC 512
Cdd:cd19379  82 VISP--VPLTRECGC 94
PHA02913 PHA02913
TGF-beta-like protein; Provisional
 404-512 3.88e-10

TGF-beta-like protein; Provisional


Pssm-ID: 177497  Cd Length: 172  Bit Score: 58.88  E-value: 3.88e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502425   404 NSSELKTACRKHELYVSFQ-DLGWQdWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQtlvHLMNPEYVPKpCCAPTK 482
Cdd:PHA02913  69 DFCDIDAICCIRDFNIDFKaDMGMK-WILKPEGTHANLCIGICSISNHKKINLMYGTAFK---HHMPDNTIPF-CCAPIK 143

                         90       100       110
                 ....*....|....*....|....*....|
gi 4502425   483 LNAISVLYFdDNSNVILKKYRNMVVRACGC 512
Cdd:PHA02913 144 MKNFIIAYK-EGRKIKTDNIKNFKILECAC 172
TGF_beta_INHA cd13754
transforming growth factor beta (TGF-beta) like domain found in inhibin alpha chain (INHA) and ...
 412-480 3.96e-08

transforming growth factor beta (TGF-beta) like domain found in inhibin alpha chain (INHA) and similar proteins; INHA is a component of inhibins (inhibin A or inhibin B) that inhibit the secretion of follitropin by the pituitary gland.


Pssm-ID: 381632  Cd Length: 89  Bit Score: 50.91  E-value: 3.96e-08
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4502425  412 CRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSfplNAHMNATNHAIvqtlvhlmnpeyvpKPCCAP 480
Cdd:cd13754   2 CHRASLNISFEELGWGNWIVHPSSFTFHYCHGTCS---SSHGLTPALGI--------------QLCCAA 53
TGF_beta_Artemin cd19381
transforming growth factor beta (TGF-beta) like domain found in Artemin and similar proteins; ...
 412-512 3.80e-04

transforming growth factor beta (TGF-beta) like domain found in Artemin and similar proteins; Artemin, also termed Enovin, or Neublastin, is a member of the glial cell-line-derived neurotrophic factor (GDNF) family with growth promoting activity on neuronal cells. It acts as the ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex. It supports peripheral and central neurons and signals through the GFR-alpha-3-RET receptor complex.


Pssm-ID: 381651  Cd Length: 98  Bit Score: 39.64  E-value: 3.80e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502425  412 CRKHELYVSFQDLGWqdwiiapkGYAA------NYCDGECSFPLNAHMNATNHAIVQTLV-HLMNPEYVPKPCCAPTKLN 484
Cdd:cd19381   2 CRLRSLRVKVRDLGL--------GYESdeivlfKYCSGSCQRARTNYDLTLNSLLKQGAIpPGPHERVSSQPCCRPTRYE 73

                        90       100
                ....*....|....*....|....*...
gi 4502425  485 AISvlyFDDNSNViLKKYRNMVVRACGC 512
Cdd:cd19381  74 NVS---FMDVQNV-WQTVEKLSAAECSC 97
TGF_beta_Neurturin cd19383
transforming growth factor beta (TGF-beta) like domain found in Neurturin and similar proteins; ...
 409-512 5.71e-04

transforming growth factor beta (TGF-beta) like domain found in Neurturin and similar proteins; Neurturin is a member of the glial cell-line-derived neurotrophic factor (GDNF) family. It acts as a neurotrophic factor that supports the survival of sympathetic neurons in culture and may regulate the development and maintenance of the CNS. It might control the size of non-neuronal cell population such as haemopoietic cells.


Pssm-ID: 381653  Cd Length: 104  Bit Score: 39.29  E-value: 5.71e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502425  409 KTACRKHELYVSFQDLGWqdwiiapkGYAAN------YCDGECSfplnAHmnATNHAIvqTLVHLMNPEYVPK------- 475
Cdd:cd19383   4 SKPCSLRELEVTVSELGL--------GYESDetvlfrYCSGKCE----AA--RRNYDL--TLKHMRGKKSLKKgrkdkvr 67

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 4502425  476 --PCCAPTKLNAiSVLYFDDNSnvilkKY---RNMVVRACGC 512
Cdd:cd19383  68 arPCCRPTAYED-DVSFLDNNN-----RYhtiQELSAKECGC 103
DNRLRE_dom NF033679
DNRLRE domain; The DNRLRE domain, with a length of about 160 amino acids, appears typically in ...
 239-329 6.69e-04

DNRLRE domain; The DNRLRE domain, with a length of about 160 amino acids, appears typically in large, repetitive surface proteins of bacteria and archaea, sometimes repeated several times. It occurs, notably, three times in the C-terminal region of the enzyme disaggregatase from the archaeal species Methanosarcina mazei, each time with the motif DNRLRE, for which the domain is named. Archaeal proteins within this family are described particularly well by the currently more narrowly defined Pfam model, PF06848. Note that the catalytic region of disaggregatase, in the N-terminal portion of the protein, is modeled by a different HMM, PF08480.


Pssm-ID: 468137 [Multi-domain]  Cd Length: 164  Bit Score: 40.44  E-value: 6.69e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502425   239 KFNLSQIPEGEVVTAAEFRIYKDCVMGSFKNQTFL-ISIYQVLQE---------HQHRDSDLFLLDTrVVWASEEGWLEF 308
Cdd:NF033679  36 KFDLSSLPAGATITSATLRLYVYYSYSTDSGTSPTtVEVYRVTSDwsestvtwnNAPAAAYASITIT-VSSVPDGGWVEI 114

                         90       100
                 ....*....|....*....|.
gi 4502425   309 DITATSNLWVVTPQHNMGLQL 329
Cdd:NF033679 115 DVTDLVQAWVSGTYPNYGFLL 135
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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