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Conserved domains on  [gi|4502443|ref|NP_001714|]
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dystonin isoform 1e precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Spectrin_like pfam18373
Spectrin like domain; Desmoplakin (DP) is an integral part of desmosomes, where it links ...
 651-728 6.30e-34

Spectrin like domain; Desmoplakin (DP) is an integral part of desmosomes, where it links desmosomal cadherins to the intermediate filaments. The N-terminal region of DP contains a plakin domain common to members of the plakin family. Plakin domains contain multiple copies of spectrin repeats (SRs) pfam00435. Spectrin repeats (SRs) consist of three alpha-helices (A, B, and C) that form an antiparallel triple-helical bundle. This entry describes SR6 which has a divergent structure relative to the other SRs. SR6 shows significant deviations in helices A and B where they are significantly shorter than in other repeats. Structural comparison revealed that SR6 is more similar to other three-helix-bundle proteins, including target of Myb1 and the syntaxin Habc domain, than to other SR proteins. Due to these differences with other spectrin repeats, this region is termed spectrin-like repeat.


:

Pssm-ID: 465730  Cd Length: 78  Bit Score: 125.79  E-value: 6.30e-34
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4502443     651 VSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKS 728
Cdd:pfam18373    1 VSWQYLLKDIQRINSWTISMLKTMRPEEYRQVLKNLETHYQDFLRDSQESEMFGAEDRRQLEREVNSAQQHYQTLLVS 78
SMC_prok_B super family cl37069
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1124-1868 4.10e-25

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


The actual alignment was detected with superfamily member TIGR02168:

Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 115.15  E-value: 4.10e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1124 QRQKATVLEN-SKLTGKISELERMVAELKKQKSRVEEELPKVREAAENELRKQQRNVEDISLQKIRAESEAKQYRRELET 1202
Cdd:TIGR02168  178 ERKLERTRENlDRLEDILNELERQLKSLERQAEKAERYKELKAELRELELALLVLRLEELREELEELQEELKEAEEELEE 257

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1203 IVREKEAAERELERVRQLTIEAEAKRAAVEENLLNFRNQLEEntftrrtLEDHLKRKDLSLNDLEQQKNKL---MEELRR 1279
Cdd:TIGR02168  258 LTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISR-------LEQQKQILRERLANLERQLEELeaqLEELES 330

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1280 KRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEiqytCRENalpvcpITQATSCRAVTGLQQEHDKQ 1359
Cdd:TIGR02168  331 KLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEE----LEEQ------LETLRSKVAQLELQIASLNN 400

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1360 KAEELKQQVDELTAANRKAEQDMRELTYELNALQLEKTSSEekarllkdkLDETNNTLRCLKLELERKDQAEKGYSQQLR 1439
Cdd:TIGR02168  401 EIERLEARLERLEDRRERLQQEIEELLKKLEEAELKELQAE---------LEELEEELEELQEELERLEEALEELREELE 471

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1440 ELGRQLNQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEK-------GKLQREVDRI-------TRAHAVAEKNIQHLN 1505
Cdd:TIGR02168  472 EAEQALDAAERELAQLQARLDSLERLQENLEGFSEGVKALLknqsglsGILGVLSELIsvdegyeAAIEAALGGRLQAVV 551

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1506 S-------QIHSFRDEKELERLQICQrKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEELEKS------------- 1565
Cdd:TIGR02168  552 VenlnaakKAIAFLKQNELGRVTFLP-LDSIKGTEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKAlsyllggvlvvdd 630

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1566 -NECAEMLKQKVEE----------------LTRQNNETKLMMQRIQAESENIVLEKQTIQQRCEALKIQADGFKDQLRST 1628
Cdd:TIGR02168  631 lDNALELAKKLRPGyrivtldgdlvrpggvITGGSAKTNSSILERRREIEELEEKIEELEEKIAELEKALAELRKELEEL 710

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1629 NEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQLQQAQ 1708
Cdd:TIGR02168  711 EEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQ 790

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1709 VQ--------------ELNNRLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFKQSAEEFRKKMEKLMESKVITENDISG 1774
Cdd:TIGR02168  791 IEqlkeelkalrealdELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEE 870

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1775 IRLDFVSLQQENSRAQENAKLCETN-------IKELERQLQQYREQMQQGQHMEANHYQKCQKLE---DELIAQKRE--- 1841
Cdd:TIGR02168  871 LESELEALLNERASLEEALALLRSEleelseeLRELESKRSELRRELEELREKLAQLELRLEGLEvriDNLQERLSEeys 950

                          810       820       830
                   ....*....|....*....|....*....|..
gi 4502443    1842 -----VENLKQKMDQQIKEHEHQLVLLQCEIQ 1868
Cdd:TIGR02168  951 ltleeAEALENKIEDDEEEARRRLKRLENKIK 982
SH3_10 pfam17902
SH3 domain; This entry represents an SH3 domain.
 550-616 5.19e-21

SH3 domain; This entry represents an SH3 domain.


:

Pssm-ID: 407754  Cd Length: 65  Bit Score: 88.47  E-value: 5.19e-21
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4502443     550 QLKPRNSdcPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVP 616
Cdd:pfam17902    1 PLKQRRS--PVTRPIPVKALCDYKQGEVTVEKGEECTLLDNSDREKWKVQTSSGVEKLVPSVCFLIP 65
SPEC cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members ...
 375-557 2.56e-19

Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; the repeats are independent folding units; tandem repeats are found in differing numbers and arrange in an antiparallel manner to form dimers; the repeats are defined by a characteristic tryptophan (W) residue in helix A and a leucine (L) at the carboxyl end of helix C and separated by a linker of 5 residues; two copies of the repeat are present here


:

Pssm-ID: 238103 [Multi-domain]  Cd Length: 213  Bit Score: 89.04  E-value: 2.56e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   375 LHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 454
Cdd:cd00176    2 LQQFLRDADELEAWLSEKEELLSSTDYGDDLESVEALLKKHEALEAELAAHEERVEALNELGEQLIEEGHPDAEEIQERL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   455 AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQrkySCDRSSSIHKLEDLVQESMEEKEELLQY 534
Cdd:cd00176   82 EELNQRWEELRELAEERRQRLEEALDLQQFFRDADDLEQWLEEKEAALA---SEDLGKDLESVEELLKKHKELEEELEAH 158

                        170       180
                 ....*....|....*....|...
gi 4502443   535 KSTIANLMGKAKTIIQLKPRNSD 557
Cdd:cd00176  159 EPRLKSLNELAEELLEEGHPDAD 181
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 2480-2517 3.88e-13

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


:

Pssm-ID: 459901  Cd Length: 39  Bit Score: 65.43  E-value: 3.88e-13
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 4502443    2480 LEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQL 2517
Cdd:pfam00681    2 LEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQKL 39
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 2170-2208 3.13e-12

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


:

Pssm-ID: 459901  Cd Length: 39  Bit Score: 62.73  E-value: 3.13e-12
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 4502443    2170 FLEAQAATGFIIDPISGQTYSVEDAVLKGVVDPEFRIRL 2208
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQKL 39
CCDC158 super family cl37899
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 811-1273 5.73e-10

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


The actual alignment was detected with superfamily member pfam15921:

Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 65.14  E-value: 5.73e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443     811 AAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLK-TVNLVLKNTQAAEalvKLYETKLCEEEAVIADKNnienliSTL 889
Cdd:pfam15921  288 SSARSQANSIQSQLEIIQEQARNQNSMYMRQLSDLEsTVSQLRSELREAK---RMYEDKIEELEKQLVLAN------SEL 358

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443     890 KQWRSEVDEKRQVFHALEDELQKAKAisdEMFKTYKERDLDfdwhKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYY 969
Cdd:pfam15921  359 TEARTERDQFSQESGNLDDQLQKLLA---DLHKREKELSLE----KEQNKRLWDRDTGNSITIDHLRRELDDRNMEVQRL 431

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443     970 RDTYHPLDDWIQ-QVETTQRKIQ-ENQP-ENSKTLATQLNQQKML----VSEIEMKQSKMDECQKYAEQYSATVKDYElq 1042
Cdd:pfam15921  432 EALLKAMKSECQgQMERQMAAIQgKNESlEKVSSLTAQLESTKEMlrkvVEELTAKKMTLESSERTVSDLTASLQEKE-- 509

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1043 tmtyRAMvdsqQKSPVKRRRMQSSADLIIQEFmdlrtrytalvtlmtQYIKFAGDSLKRLEEEEIKRCKETSEHGAYSDL 1122
Cdd:pfam15921  510 ----RAI----EATNAEITKLRSRVDLKLQEL---------------QHLKNEGDHLRNVQTECEALKLQMAEKDKVIEI 566

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1123 LQRQKATVLENSKLTGKIS---ELERMVAELKKQKSRVE-EELPKVREAAENELRKQQRNVEDISLQKIRAESEAKQYRR 1198
Cdd:pfam15921  567 LRQQIENMTQLVGQHGRTAgamQVEKAQLEKEINDRRLElQEFKILKDKKDAKIRELEARVSDLELEKVKLVNAGSERLR 646

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4502443    1199 ELETIVREKEAAERELERVRQltiEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRkdlSLNDLEQQKNKL 1273
Cdd:pfam15921  647 AVKDIKQERDQLLNEVKTSRN---ELNSLSEDYEVLKRNFRNKSEEMETTTNKLKMQLKS---AQSELEQTRNTL 715
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 2244-2282 1.76e-08

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


:

Pssm-ID: 459901  Cd Length: 39  Bit Score: 52.33  E-value: 1.76e-08
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 4502443    2244 ILEAQIASGGVIDPVRGIRVPPEIALQQGLLNNAILQFL 2282
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQKL 39
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 2556-2593 4.77e-08

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


:

Pssm-ID: 459901  Cd Length: 39  Bit Score: 50.79  E-value: 4.77e-08
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 4502443    2556 LEFQYLTGGLIEPQVHSRLSIEEALQVGIIDVLIATKL 2593
Cdd:pfam00681    2 LEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQKL 39
SPEC smart00150
Spectrin repeats;
282-373 8.73e-07

Spectrin repeats;


:

Pssm-ID: 197544 [Multi-domain]  Cd Length: 101  Bit Score: 49.25  E-value: 8.73e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443      282 VQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTA---PLKLTYAEKLHRLESQY 358
Cdd:smart00150    7 ADELEAWLEEKEQLLASEDLGKDLESVEALLKKHEAFEAELEAHEERVEALNELGEQLIEeghPDAEEIEERLEELNERW 86

                            90
                    ....*....|....*
gi 4502443      359 AKLLNTSRNQERHLD 373
Cdd:smart00150   87 EELKELAEERRQKLE 101
PLEC smart00250
Plectin repeat;
2515-2552 1.51e-04

Plectin repeat;


:

Pssm-ID: 197605  Cd Length: 38  Bit Score: 40.93  E-value: 1.51e-04
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 4502443     2515 QQLRQCELVITGIGHPITNKMMSVVEAVNANIINKEMG 2552
Cdd:smart00250    1 QRLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
PLEC smart00250
Plectin repeat;
2446-2476 2.59e-03

Plectin repeat;


:

Pssm-ID: 197605  Cd Length: 38  Bit Score: 37.46  E-value: 2.59e-03
                            10        20        30
                    ....*....|....*....|....*....|.
gi 4502443     2446 SPVAGYWLTASGERISVLKASRRNLVDRITA 2476
Cdd:smart00250    8 SAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
PLEC smart00250
Plectin repeat;
2337-2366 8.61e-03

Plectin repeat;


:

Pssm-ID: 197605  Cd Length: 38  Bit Score: 36.31  E-value: 8.61e-03
                            10        20        30
                    ....*....|....*....|....*....|
gi 4502443     2337 HRISVVDTKTGSELTVYEAFQRNLIEKSIY 2366
Cdd:smart00250    9 AIGGIIDPETGQKLSVEEALRRGLIDPETG 38
 
Name Accession Description Interval E-value
Spectrin_like pfam18373
Spectrin like domain; Desmoplakin (DP) is an integral part of desmosomes, where it links ...
 651-728 6.30e-34

Spectrin like domain; Desmoplakin (DP) is an integral part of desmosomes, where it links desmosomal cadherins to the intermediate filaments. The N-terminal region of DP contains a plakin domain common to members of the plakin family. Plakin domains contain multiple copies of spectrin repeats (SRs) pfam00435. Spectrin repeats (SRs) consist of three alpha-helices (A, B, and C) that form an antiparallel triple-helical bundle. This entry describes SR6 which has a divergent structure relative to the other SRs. SR6 shows significant deviations in helices A and B where they are significantly shorter than in other repeats. Structural comparison revealed that SR6 is more similar to other three-helix-bundle proteins, including target of Myb1 and the syntaxin Habc domain, than to other SR proteins. Due to these differences with other spectrin repeats, this region is termed spectrin-like repeat.


Pssm-ID: 465730  Cd Length: 78  Bit Score: 125.79  E-value: 6.30e-34
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4502443     651 VSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKS 728
Cdd:pfam18373    1 VSWQYLLKDIQRINSWTISMLKTMRPEEYRQVLKNLETHYQDFLRDSQESEMFGAEDRRQLEREVNSAQQHYQTLLVS 78
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1124-1868 4.10e-25

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 115.15  E-value: 4.10e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1124 QRQKATVLEN-SKLTGKISELERMVAELKKQKSRVEEELPKVREAAENELRKQQRNVEDISLQKIRAESEAKQYRRELET 1202
Cdd:TIGR02168  178 ERKLERTRENlDRLEDILNELERQLKSLERQAEKAERYKELKAELRELELALLVLRLEELREELEELQEELKEAEEELEE 257

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1203 IVREKEAAERELERVRQLTIEAEAKRAAVEENLLNFRNQLEEntftrrtLEDHLKRKDLSLNDLEQQKNKL---MEELRR 1279
Cdd:TIGR02168  258 LTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISR-------LEQQKQILRERLANLERQLEELeaqLEELES 330

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1280 KRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEiqytCRENalpvcpITQATSCRAVTGLQQEHDKQ 1359
Cdd:TIGR02168  331 KLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEE----LEEQ------LETLRSKVAQLELQIASLNN 400

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1360 KAEELKQQVDELTAANRKAEQDMRELTYELNALQLEKTSSEekarllkdkLDETNNTLRCLKLELERKDQAEKGYSQQLR 1439
Cdd:TIGR02168  401 EIERLEARLERLEDRRERLQQEIEELLKKLEEAELKELQAE---------LEELEEELEELQEELERLEEALEELREELE 471

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1440 ELGRQLNQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEK-------GKLQREVDRI-------TRAHAVAEKNIQHLN 1505
Cdd:TIGR02168  472 EAEQALDAAERELAQLQARLDSLERLQENLEGFSEGVKALLknqsglsGILGVLSELIsvdegyeAAIEAALGGRLQAVV 551

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1506 S-------QIHSFRDEKELERLQICQrKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEELEKS------------- 1565
Cdd:TIGR02168  552 VenlnaakKAIAFLKQNELGRVTFLP-LDSIKGTEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKAlsyllggvlvvdd 630

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1566 -NECAEMLKQKVEE----------------LTRQNNETKLMMQRIQAESENIVLEKQTIQQRCEALKIQADGFKDQLRST 1628
Cdd:TIGR02168  631 lDNALELAKKLRPGyrivtldgdlvrpggvITGGSAKTNSSILERRREIEELEEKIEELEEKIAELEKALAELRKELEEL 710

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1629 NEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQLQQAQ 1708
Cdd:TIGR02168  711 EEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQ 790

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1709 VQ--------------ELNNRLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFKQSAEEFRKKMEKLMESKVITENDISG 1774
Cdd:TIGR02168  791 IEqlkeelkalrealdELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEE 870

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1775 IRLDFVSLQQENSRAQENAKLCETN-------IKELERQLQQYREQMQQGQHMEANHYQKCQKLE---DELIAQKRE--- 1841
Cdd:TIGR02168  871 LESELEALLNERASLEEALALLRSEleelseeLRELESKRSELRRELEELREKLAQLELRLEGLEvriDNLQERLSEeys 950

                          810       820       830
                   ....*....|....*....|....*....|..
gi 4502443    1842 -----VENLKQKMDQQIKEHEHQLVLLQCEIQ 1868
Cdd:TIGR02168  951 ltleeAEALENKIEDDEEEARRRLKRLENKIK 982
SH3_10 pfam17902
SH3 domain; This entry represents an SH3 domain.
 550-616 5.19e-21

SH3 domain; This entry represents an SH3 domain.


Pssm-ID: 407754  Cd Length: 65  Bit Score: 88.47  E-value: 5.19e-21
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4502443     550 QLKPRNSdcPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVP 616
Cdd:pfam17902    1 PLKQRRS--PVTRPIPVKALCDYKQGEVTVEKGEECTLLDNSDREKWKVQTSSGVEKLVPSVCFLIP 65
SPEC cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members ...
 375-557 2.56e-19

Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; the repeats are independent folding units; tandem repeats are found in differing numbers and arrange in an antiparallel manner to form dimers; the repeats are defined by a characteristic tryptophan (W) residue in helix A and a leucine (L) at the carboxyl end of helix C and separated by a linker of 5 residues; two copies of the repeat are present here


Pssm-ID: 238103 [Multi-domain]  Cd Length: 213  Bit Score: 89.04  E-value: 2.56e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   375 LHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 454
Cdd:cd00176    2 LQQFLRDADELEAWLSEKEELLSSTDYGDDLESVEALLKKHEALEAELAAHEERVEALNELGEQLIEEGHPDAEEIQERL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   455 AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQrkySCDRSSSIHKLEDLVQESMEEKEELLQY 534
Cdd:cd00176   82 EELNQRWEELRELAEERRQRLEEALDLQQFFRDADDLEQWLEEKEAALA---SEDLGKDLESVEELLKKHKELEEELEAH 158

                        170       180
                 ....*....|....*....|...
gi 4502443   535 KSTIANLMGKAKTIIQLKPRNSD 557
Cdd:cd00176  159 EPRLKSLNELAEELLEEGHPDAD 181
PTZ00121 PTZ00121
MAEBL; Provisional
 1097-1800 3.07e-19

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 95.98  E-value: 3.07e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1097 DSLKRLEE----EEIKRCKETSEHGAYSDLLQRQKATVLENSKLTGKISELERMVAELKKQKSRVEEELPKVREAAENEL 1172
Cdd:PTZ00121 1125 EDARKAEEarkaEDARKAEEARKAEDAKRVEIARKAEDARKAEEARKAEDAKKAEAARKAEEVRKAEELRKAEDARKAEA 1204

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1173 RKQQRNVEDIS-LQKIRAESEAKQYRRELETIVREKEAAERELER-----------------VRQLTIEAEAKRAAVEEN 1234
Cdd:PTZ00121 1205 ARKAEEERKAEeARKAEDAKKAEAVKKAEEAKKDAEEAKKAEEERnneeirkfeearmahfaRRQAAIKAEEARKADELK 1284

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1235 LLNFRNQLEEntfTRRTLE----DHLKRKDLSLNDLEQQKNKLME------ELRRKRDNEEELLKLIKQMEKDLAFQKQV 1304
Cdd:PTZ00121 1285 KAEEKKKADE---AKKAEEkkkaDEAKKKAEEAKKADEAKKKAEEakkkadAAKKKAEEAKKAAEAAKAEAEAAADEAEA 1361

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1305 AEKQLKEKQKIELEARRKITEIQYTCRENAlpvcpitqatscravtglQQEHDKQKAEELKQQVDEL---TAANRKAEQD 1381
Cdd:PTZ00121 1362 AEEKAEAAEKKKEEAKKKADAAKKKAEEKK------------------KADEAKKKAEEDKKKADELkkaAAAKKKADEA 1423

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1382 MRELTYELNALQLEKTSSE-EKARLLKDKLDETNntlrclKLELERKDQAEKGYSQQLR---ELGRQLNQTTGKAEEAMQ 1457
Cdd:PTZ00121 1424 KKKAEEKKKADEAKKKAEEaKKADEAKKKAEEAK------KAEEAKKKAEEAKKADEAKkkaEEAKKADEAKKKAEEAKK 1497

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1458 EASDLKKIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFRDEKEL----------------ERLQ 1521
Cdd:PTZ00121 1498 KADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEELkkaeekkkaeeakkaeEDKN 1577

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1522 ICQRKSDHLKEQFEKSHEQLLQNIKAEKENN-DKIQRLNEELEKSNEC--AEMLKQKVEELTRQNNETKLMMQRIQAESE 1598
Cdd:PTZ00121 1578 MALRKAEEAKKAEEARIEEVMKLYEEEKKMKaEEAKKAEEAKIKAEELkkAEEEKKKVEQLKKKEAEEKKKAEELKKAEE 1657

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1599 NIVLEKQTIQQRCEALKIQAdgfkDQLRSTNEHLHK---QTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQKCDQQNIIIQ 1675
Cdd:PTZ00121 1658 ENKIKAAEEAKKAEEDKKKA----EEAKKAEEDEKKaaeALKKEAEEAKKAEELKKKEAEEKKKAEELKKAEEENKIKAE 1733

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1676 NTKKEvrnlnaelnaSKEEKRRGEQ--KVQLQQAQVQELNNRLKKVQDELHLK---TIEEQMTHRKMVLFQEESGKFKQS 1750
Cdd:PTZ00121 1734 EAKKE----------AEEDKKKAEEakKDEEEKKKIAHLKKEEEKKAEEIRKEkeaVIEEELDEEDEKRRMEVDKKIKDI 1803

                         730       740       750       760       770
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 4502443   1751 AEEFRKKMEKLMESKVIT----ENDISGIR--LDFVSLQQENSRAQENAKLCETNI 1800
Cdd:PTZ00121 1804 FDNFANIIEGGKEGNLVIndskEMEDSAIKevADSKNMQLEEADAFEKHKFNKNNE 1859
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1140-1718 9.26e-17

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 87.30  E-value: 9.26e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1140 ISELERMVAELKKQKSR------VEEELpKVREAAE--NELRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAE 1211
Cdd:COG1196  195 LGELERQLEPLERQAEKaeryreLKEEL-KELEAELllLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELR 273

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1212 RELERVRQLTIEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKLI 1291
Cdd:COG1196  274 LELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEEL 353

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1292 KQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQytcrenalpvcpitQATSCRAVTGLQQEHDKQKAEELKQQVDEL 1371
Cdd:COG1196  354 EEAEAELAEAEEALLEAEAELAEAEEELEELAEELL--------------EALRAAAELAAQLEELEEAEEALLERLERL 419

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1372 TAANRKAEQDMREltyELNALQLEKTSSEEKARLLKDKLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLNQTTGK 1451
Cdd:COG1196  420 EEELEELEEALAE---LEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLL 496

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1452 AEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFRDEKELERL----------- 1520
Cdd:COG1196  497 LEAEADYEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAALEAALAAALQNIVVEDDEVAAAAIEYlkaakagratf 576

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1521 ----QICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEELEKSN---ECAEMLKQKVEELTRQNNETKLMMQRI 1593
Cdd:COG1196  577 lpldKIRARAALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTlvaARLEAALRRAVTLAGRLREVTLEGEGG 656

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1594 QAESENIVLEKQTIQQRCEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQkcdQQNII 1673
Cdd:COG1196  657 SAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEE---QLEAE 733

                        570       580       590       600
                 ....*....|....*....|....*....|....*....|....*
gi 4502443  1674 IQNTKKEVRNLNAELNASKEEKRRGEQKVQLQQAQVQELNNRLKK 1718
Cdd:COG1196  734 REELLEELLEEEELLEEEALEELPEPPDLEELERELERLEREIEA 778
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 935-1721 7.21e-16

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 84.78  E-value: 7.21e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443     935 KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYY-RDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVS 1013
Cdd:pfam15921   73 KEHIERVLEEYSHQVKDLQRRLNESNELHEKQKFYlRQSVIDLQTKLQEMQMERDAMADIRRRESQSQEDLRNQLQNTVH 152

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1014 EIE----MKQSKMDECQKYAEQYSATVKDYELQTMTYRA-MVDSQQKSPVKRRRMQSSADLiiqEFMDLRTRYTALVTLM 1088
Cdd:pfam15921  153 ELEaakcLKEDMLEDSNTQIEQLRKMMLSHEGVLQEIRSiLVDFEEASGKKIYEHDSMSTM---HFRSLGSAISKILREL 229

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1089 TQYIKFAGDSLKRLEEEeIKRCKETSEHGAYSDLLQRQKATVLENSKLTGKISELERMVAELKKQKSRVEEELPKVREAA 1168
Cdd:pfam15921  230 DTEISYLKGRIFPVEDQ-LEALKSESQNKIELLLQQHQDRIEQLISEHEVEITGLTEKASSARSQANSIQSQLEIIQEQA 308

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1169 ENELRKQQRNVEDIslqkiraESEAKQYRRELETIVREKEAAERELERvrQLTI------EAEAKRAAVEENLLNFRNQL 1242
Cdd:pfam15921  309 RNQNSMYMRQLSDL-------ESTVSQLRSELREAKRMYEDKIEELEK--QLVLanseltEARTERDQFSQESGNLDDQL 379

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1243 EentftrRTLED-HLKRKDLSLndlEQQKNKLMEElrRKRDNEEELLKLIKQMEkDLAFQKQVAEKQLKE-KQKIELEAR 1320
Cdd:pfam15921  380 Q------KLLADlHKREKELSL---EKEQNKRLWD--RDTGNSITIDHLRRELD-DRNMEVQRLEALLKAmKSECQGQME 447

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1321 RKITEIQytcrenalpvcpiTQATSCRAVTGLQQEHDKQKaEELKQQVDELTAANRKAEQDMRELTYELNALQ-----LE 1395
Cdd:pfam15921  448 RQMAAIQ-------------GKNESLEKVSSLTAQLESTK-EMLRKVVEELTAKKMTLESSERTVSDLTASLQekeraIE 513

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1396 KTSSE------------EKARLLKDKLDETNNT---LRCLKLELERKDQAEKGYSQQLRELgRQLNQTTGKAEEAMQ-EA 1459
Cdd:pfam15921  514 ATNAEitklrsrvdlklQELQHLKNEGDHLRNVqteCEALKLQMAEKDKVIEILRQQIENM-TQLVGQHGRTAGAMQvEK 592

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1460 SDLKKIKRNYQLELESLNHEKGKlqrevdritrahavAEKNIQHLNSQIHSFrdekELERLQICQRKSDHLK--EQFEKS 1537
Cdd:pfam15921  593 AQLEKEINDRRLELQEFKILKDK--------------KDAKIRELEARVSDL----ELEKVKLVNAGSERLRavKDIKQE 654

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1538 HEQLLQNIKAEKennDKIQRLNEELE--KSNecaemLKQKVEELTRQNNETKLMMQRIQAESENIVLEKQTIQ-QRCEAL 1614
Cdd:pfam15921  655 RDQLLNEVKTSR---NELNSLSEDYEvlKRN-----FRNKSEEMETTTNKLKMQLKSAQSELEQTRNTLKSMEgSDGHAM 726

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1615 KIqADGFKDQLRSTNEHLHKqtkteqdFQRKIKCLEEDLA---KSQNLVSEFKQKCDQQniiIQNTKKEVRNLNAELNAS 1691
Cdd:pfam15921  727 KV-AMGMQKQITAKRGQIDA-------LQSKIQFLEEAMTnanKEKHFLKEEKNKLSQE---LSTVATEKNKMAGELEVL 795

                          810       820       830
                   ....*....|....*....|....*....|
gi 4502443    1692 KEEKRRGEQKVQLQQAQVQELNNRLKKVQD 1721
Cdd:pfam15921  796 RSQERRLKEKVANMEVALDKASLQFAECQD 825
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 2480-2517 3.88e-13

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 459901  Cd Length: 39  Bit Score: 65.43  E-value: 3.88e-13
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 4502443    2480 LEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQL 2517
Cdd:pfam00681    2 LEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQKL 39
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 2170-2208 3.13e-12

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 459901  Cd Length: 39  Bit Score: 62.73  E-value: 3.13e-12
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 4502443    2170 FLEAQAATGFIIDPISGQTYSVEDAVLKGVVDPEFRIRL 2208
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQKL 39
SPEC smart00150
Spectrin repeats;
376-476 2.35e-10

Spectrin repeats;


Pssm-ID: 197544 [Multi-domain]  Cd Length: 101  Bit Score: 59.65  E-value: 2.35e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443      376 HNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRA 455
Cdd:smart00150    1 QQFLRDADELEAWLEEKEQLLASEDLGKDLESVEALLKKHEAFEAELEAHEERVEALNELGEQLIEEGHPDAEEIEERLE 80

                            90       100
                    ....*....|....*....|.
gi 4502443      456 AMQTQWSWILQLCQCVEQHIK 476
Cdd:smart00150   81 ELNERWEELKELAEERRQKLE 101
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 811-1273 5.73e-10

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 65.14  E-value: 5.73e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443     811 AAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLK-TVNLVLKNTQAAEalvKLYETKLCEEEAVIADKNnienliSTL 889
Cdd:pfam15921  288 SSARSQANSIQSQLEIIQEQARNQNSMYMRQLSDLEsTVSQLRSELREAK---RMYEDKIEELEKQLVLAN------SEL 358

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443     890 KQWRSEVDEKRQVFHALEDELQKAKAisdEMFKTYKERDLDfdwhKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYY 969
Cdd:pfam15921  359 TEARTERDQFSQESGNLDDQLQKLLA---DLHKREKELSLE----KEQNKRLWDRDTGNSITIDHLRRELDDRNMEVQRL 431

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443     970 RDTYHPLDDWIQ-QVETTQRKIQ-ENQP-ENSKTLATQLNQQKML----VSEIEMKQSKMDECQKYAEQYSATVKDYElq 1042
Cdd:pfam15921  432 EALLKAMKSECQgQMERQMAAIQgKNESlEKVSSLTAQLESTKEMlrkvVEELTAKKMTLESSERTVSDLTASLQEKE-- 509

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1043 tmtyRAMvdsqQKSPVKRRRMQSSADLIIQEFmdlrtrytalvtlmtQYIKFAGDSLKRLEEEEIKRCKETSEHGAYSDL 1122
Cdd:pfam15921  510 ----RAI----EATNAEITKLRSRVDLKLQEL---------------QHLKNEGDHLRNVQTECEALKLQMAEKDKVIEI 566

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1123 LQRQKATVLENSKLTGKIS---ELERMVAELKKQKSRVE-EELPKVREAAENELRKQQRNVEDISLQKIRAESEAKQYRR 1198
Cdd:pfam15921  567 LRQQIENMTQLVGQHGRTAgamQVEKAQLEKEINDRRLElQEFKILKDKKDAKIRELEARVSDLELEKVKLVNAGSERLR 646

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4502443    1199 ELETIVREKEAAERELERVRQltiEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRkdlSLNDLEQQKNKL 1273
Cdd:pfam15921  647 AVKDIKQERDQLLNEVKTSRN---ELNSLSEDYEVLKRNFRNKSEEMETTTNKLKMQLKS---AQSELEQTRNTL 715
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
883-1326 6.60e-09

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 61.32  E-value: 6.60e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   883 ENLISTLKQWRSEVDEKRQV---FHALEDELQKAKAISDEMFKTYKERDLDFDwHKEKADQLVERWQNVHvQIDNRLRDL 959
Cdd:COG4717   67 ELNLKELKELEEELKEAEEKeeeYAELQEELEELEEELEELEAELEELREELE-KLEKLLQLLPLYQELE-ALEAELAEL 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   960 EGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQE--------NQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQ 1031
Cdd:COG4717  145 PERLEELEERLEELRELEEELEELEAELAELQEeleelleqLSLATEEELQDLAEELEELQQRLAELEEELEEAQEELEE 224

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1032 YSATVKDYELQtmtyrAMVDSQQKSPVKRRRMQSSADLII------QEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEE 1105
Cdd:COG4717  225 LEEELEQLENE-----LEAAALEERLKEARLLLLIAAALLallglgGSLLSLILTIAGVLFLVLGLLALLFLLLAREKAS 299

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1106 EIKRCKETSEHGAYSDLLQRQKATVLENSKLTGKIS-----ELERMVAELKKQKSRVEEELpkvREAAENELRKQQRNVe 1180
Cdd:COG4717  300 LGKEAEELQALPALEELEEEELEELLAALGLPPDLSpeellELLDRIEELQELLREAEELE---EELQLEELEQEIAAL- 375

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1181 disLQKIRAESEAkqyrrELETIVREKEAAERELERVRQLTIEAEAKRAAVEENLlnfrnqleeNTFTRRTLEDHLKRKD 1260
Cdd:COG4717  376 ---LAEAGVEDEE-----ELRAALEQAEEYQELKEELEELEEQLEELLGELEELL---------EALDEEELEEELEELE 438

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4502443  1261 LSLNDLEQQKNKLMEELRrkrdneeELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEI 1326
Cdd:COG4717  439 EELEELEEELEELREELA-------ELEAELEQLEEDGELAELLQELEELKAELRELAEEWAALKL 497
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 2244-2282 1.76e-08

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 459901  Cd Length: 39  Bit Score: 52.33  E-value: 1.76e-08
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 4502443    2244 ILEAQIASGGVIDPVRGIRVPPEIALQQGLLNNAILQFL 2282
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQKL 39
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 2556-2593 4.77e-08

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 459901  Cd Length: 39  Bit Score: 50.79  E-value: 4.77e-08
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 4502443    2556 LEFQYLTGGLIEPQVHSRLSIEEALQVGIIDVLIATKL 2593
Cdd:pfam00681    2 LEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQKL 39
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
761-1326 4.85e-08

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 58.92  E-value: 4.85e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    761 IRQ--IRTPLERDDLHESVFR-ITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVL-QNMNQVYS 836
Cdd:PRK03918  132 IRQgeIDAILESDESREKVVRqILGLDDYENAYKNLGEVIKEIKRRIERLEKFIKRTENIEELIKEKEKELeEVLREINE 211

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    837 MSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAI 916
Cdd:PRK03918  212 ISSELPELREELEKLEKEVKELEELKEEIEELEKELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKVKELKELKEK 291

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    917 SDEMFKTYKERDlDFDWHKEKADQLVERWQNVHVQIDNRLRDLEG-------IGKSLKYYRDTYHPLDDWIQQVETTQRK 989
Cdd:PRK03918  292 AEEYIKLSEFYE-EYLDELREIEKRLSRLEEEINGIEERIKELEEkeerleeLKKKLKELEKRLEELEERHELYEEAKAK 370

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    990 iqENQPENSKTLATQLNQQKmLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVD----SQQKSPVKRRrmqs 1065
Cdd:PRK03918  371 --KEELERLKKRLTGLTPEK-LEKELEELEKAKEEIEEEISKITARIGELKKEIKELKKAIEelkkAKGKCPVCGR---- 443

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1066 saDLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEHGAYSDLLQ--------------------R 1125
Cdd:PRK03918  444 --ELTEEHRKELLEEYTAELKRIEKELKEIEEKERKLRKELRELEKVLKKESELIKLKElaeqlkeleeklkkynleelE 521

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1126 QKATVLENSK-----LTGKISELERMV---AELKKQKSRVEEELPKVREAAENELRK-QQRNVEDISLQKIRAESEAKQY 1196
Cdd:PRK03918  522 KKAEEYEKLKeklikLKGEIKSLKKELeklEELKKKLAELEKKLDELEEELAELLKElEELGFESVEELEERLKELEPFY 601

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1197 RR--ELETIVREKEAAERELERVRQLTIEAEAKRAAVEENLLNFRNQLEE--------------NTFTRrtLEDHLKRKD 1260
Cdd:PRK03918  602 NEylELKDAEKELEREEKELKKLEEELDKAFEELAETEKRLEELRKELEElekkyseeeyeelrEEYLE--LSRELAGLR 679

                         570       580       590       600       610       620
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4502443   1261 LSLNDLEQQKN---KLMEELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEI 1326
Cdd:PRK03918  680 AELEELEKRREeikKTLEKLKEELEEREKAKKELEKLEKALERVEELREKVKKYKALLKERALSKVGEI 748
PLEC smart00250
Plectin repeat;
2170-2205 7.05e-08

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 50.56  E-value: 7.05e-08
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 4502443     2170 FLEAQAATGFIIDPISGQTYSVEDAVLKGVVDPEFR 2205
Cdd:smart00250    3 LLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
PLEC smart00250
Plectin repeat;
2477-2514 9.55e-08

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 50.17  E-value: 9.55e-08
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 4502443     2477 LRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFA 2514
Cdd:smart00250    1 QRLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
SPEC smart00150
Spectrin repeats;
282-373 8.73e-07

Spectrin repeats;


Pssm-ID: 197544 [Multi-domain]  Cd Length: 101  Bit Score: 49.25  E-value: 8.73e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443      282 VQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTA---PLKLTYAEKLHRLESQY 358
Cdd:smart00150    7 ADELEAWLEEKEQLLASEDLGKDLESVEALLKKHEAFEAELEAHEERVEALNELGEQLIEeghPDAEEIEERLEELNERW 86

                            90
                    ....*....|....*
gi 4502443      359 AKLLNTSRNQERHLD 373
Cdd:smart00150   87 EELKELAEERRQKLE 101
PLEC smart00250
Plectin repeat;
2553-2586 5.80e-06

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 45.17  E-value: 5.80e-06
                            10        20        30
                    ....*....|....*....|....*....|....
gi 4502443     2553 IRCLEFQYLTGGLIEPQVHSRLSIEEALQVGIID 2586
Cdd:smart00250    1 QRLLEAQSAIGGIIDPETGQKLSVEEALRRGLID 34
MARTX_Nterm NF012221
MARTX multifunctional-autoprocessing repeats-in-toxin holotoxin N-terminal region; This model ...
 1524-1710 3.46e-05

MARTX multifunctional-autoprocessing repeats-in-toxin holotoxin N-terminal region; This model describes the N-terminal 1900 amino acids of MARTX family multifunctional-autoprocessing repeats-in-toxin holotoxins, which contain both repeat regions that facilitate their entry into eukaryotic target cells, and multiple effector domains.


Pssm-ID: 467957 [Multi-domain]  Cd Length: 1848  Bit Score: 49.83  E-value: 3.46e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1524 QRKSDHLKEQFEKSheQLLQNIKAEKENNDK-IQRLneELEKSNECAEMLK-QKVEELTRQNN-ETKLMMQR--IQAESE 1598
Cdd:NF012221 1541 SQQADAVSKHAKQD--DAAQNALADKERAEAdRQRL--EQEKQQQLAAISGsQSQLESTDQNAlETNGQAQRdaILEESR 1616

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1599 NIVLEKQTIQQRCEALKIQ---------------ADGFKD----QLRSTNEHLHKQ-TKTEQDFQRKIKCLEEDLAKSQN 1658
Cdd:NF012221 1617 AVTKELTTLAQGLDALDSQatyagesgdqwrnpfAGGLLDrvqeQLDDAKKISGKQlADAKQRHVDNQQKVKDAVAKSEA 1696

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1659 LV--SEFKQKCDQQNIIIQNTKKEVRNLNAELN-------------ASKEEKRRGEQKV---QLQQAQVQ 1710
Cdd:NF012221 1697 GVaqGEQNQANAEQDIDDAKADAEKRKDDALAKqneaqqaesdanaAANDAQSRGEQDAsaaENKANQAQ 1766
Spectrin pfam00435
Spectrin repeat; Spectrin repeat-domains are found in several proteins involved in ...
 375-469 9.88e-05

Spectrin repeat; Spectrin repeat-domains are found in several proteins involved in cytoskeletal structure. These include spectrin, alpha-actinin and dystrophin. The sequence repeat used in this family is taken from the structural repeat in reference. The spectrin domain- repeat forms a three helix bundle. The second helix is interrupted by proline in some sequences. The repeats are defined by a characteriztic tryptophan (W) residue at position 17 in helix A and a leucine (L) at 2 residues from the carboxyl end of helix C. Although the domain occurs in multiple repeats along sequences, the domains are actually stable on their own - ie they act, biophysically, like domains rather than repeats that along function when aggregated.


Pssm-ID: 395348 [Multi-domain]  Cd Length: 105  Bit Score: 43.85  E-value: 9.88e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443     375 LHNFVSRATNELIWLNEKEE----EEVAYDWSErntnIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTI 450
Cdd:pfam00435    3 LQQFFRDADDLESWIEEKEAllssEDYGKDLES----VQALLKKHKALEAELAAHQDRVEALNELAEKLIDEGHYASEEI 78

                           90
                   ....*....|....*....
gi 4502443     451 EAYRAAMQTQWSWILQLCQ 469
Cdd:pfam00435   79 QERLEELNERWEQLLELAA 97
PLEC smart00250
Plectin repeat;
2515-2552 1.51e-04

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 40.93  E-value: 1.51e-04
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 4502443     2515 QQLRQCELVITGIGHPITNKMMSVVEAVNANIINKEMG 2552
Cdd:smart00250    1 QRLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
PLEC smart00250
Plectin repeat;
2242-2274 1.51e-04

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 40.93  E-value: 1.51e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 4502443     2242 KHILEAQIASGGVIDPVRGIRVPPEIALQQGLL 2274
Cdd:smart00250    1 QRLLEAQSAIGGIIDPETGQKLSVEEALRRGLI 33
SPEC cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members ...
 868-1032 1.61e-03

Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; the repeats are independent folding units; tandem repeats are found in differing numbers and arrange in an antiparallel manner to form dimers; the repeats are defined by a characteristic tryptophan (W) residue in helix A and a leucine (L) at the carboxyl end of helix C and separated by a linker of 5 residues; two copies of the repeat are present here


Pssm-ID: 238103 [Multi-domain]  Cd Length: 213  Bit Score: 42.43  E-value: 1.61e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   868 KLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEdelQKAKAISDEmfktykeRDLDFDWHKEKADQLVERWQN 947
Cdd:cd00176   21 ELLSSTDYGDDLESVEALLKKHEALEAELAAHEERVEALN---ELGEQLIEE-------GHPDAEEIQERLEELNQRWEE 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   948 VHVQIDNRLRDLEGIGKSLKYYRDTYHpLDDWIQqvETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQK 1027
Cdd:cd00176   91 LRELAEERRQRLEEALDLQQFFRDADD-LEQWLE--EKEAALASEDLGKDLESVEELLKKHKELEEELEAHEPRLKSLNE 167


                 ....*
gi 4502443  1028 YAEQY 1032
Cdd:cd00176  168 LAEEL 172
PLEC smart00250
Plectin repeat;
2446-2476 2.59e-03

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 37.46  E-value: 2.59e-03
                            10        20        30
                    ....*....|....*....|....*....|.
gi 4502443     2446 SPVAGYWLTASGERISVLKASRRNLVDRITA 2476
Cdd:smart00250    8 SAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
PLEC smart00250
Plectin repeat;
2337-2366 8.61e-03

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 36.31  E-value: 8.61e-03
                            10        20        30
                    ....*....|....*....|....*....|
gi 4502443     2337 HRISVVDTKTGSELTVYEAFQRNLIEKSIY 2366
Cdd:smart00250    9 AIGGIIDPETGQKLSVEEALRRGLIDPETG 38
 
Name Accession Description Interval E-value
Spectrin_like pfam18373
Spectrin like domain; Desmoplakin (DP) is an integral part of desmosomes, where it links ...
 651-728 6.30e-34

Spectrin like domain; Desmoplakin (DP) is an integral part of desmosomes, where it links desmosomal cadherins to the intermediate filaments. The N-terminal region of DP contains a plakin domain common to members of the plakin family. Plakin domains contain multiple copies of spectrin repeats (SRs) pfam00435. Spectrin repeats (SRs) consist of three alpha-helices (A, B, and C) that form an antiparallel triple-helical bundle. This entry describes SR6 which has a divergent structure relative to the other SRs. SR6 shows significant deviations in helices A and B where they are significantly shorter than in other repeats. Structural comparison revealed that SR6 is more similar to other three-helix-bundle proteins, including target of Myb1 and the syntaxin Habc domain, than to other SR proteins. Due to these differences with other spectrin repeats, this region is termed spectrin-like repeat.


Pssm-ID: 465730  Cd Length: 78  Bit Score: 125.79  E-value: 6.30e-34
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4502443     651 VSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKS 728
Cdd:pfam18373    1 VSWQYLLKDIQRINSWTISMLKTMRPEEYRQVLKNLETHYQDFLRDSQESEMFGAEDRRQLEREVNSAQQHYQTLLVS 78
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1124-1868 4.10e-25

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 115.15  E-value: 4.10e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1124 QRQKATVLEN-SKLTGKISELERMVAELKKQKSRVEEELPKVREAAENELRKQQRNVEDISLQKIRAESEAKQYRRELET 1202
Cdd:TIGR02168  178 ERKLERTRENlDRLEDILNELERQLKSLERQAEKAERYKELKAELRELELALLVLRLEELREELEELQEELKEAEEELEE 257

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1203 IVREKEAAERELERVRQLTIEAEAKRAAVEENLLNFRNQLEEntftrrtLEDHLKRKDLSLNDLEQQKNKL---MEELRR 1279
Cdd:TIGR02168  258 LTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISR-------LEQQKQILRERLANLERQLEELeaqLEELES 330

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1280 KRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEiqytCRENalpvcpITQATSCRAVTGLQQEHDKQ 1359
Cdd:TIGR02168  331 KLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEE----LEEQ------LETLRSKVAQLELQIASLNN 400

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1360 KAEELKQQVDELTAANRKAEQDMRELTYELNALQLEKTSSEekarllkdkLDETNNTLRCLKLELERKDQAEKGYSQQLR 1439
Cdd:TIGR02168  401 EIERLEARLERLEDRRERLQQEIEELLKKLEEAELKELQAE---------LEELEEELEELQEELERLEEALEELREELE 471

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1440 ELGRQLNQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEK-------GKLQREVDRI-------TRAHAVAEKNIQHLN 1505
Cdd:TIGR02168  472 EAEQALDAAERELAQLQARLDSLERLQENLEGFSEGVKALLknqsglsGILGVLSELIsvdegyeAAIEAALGGRLQAVV 551

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1506 S-------QIHSFRDEKELERLQICQrKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEELEKS------------- 1565
Cdd:TIGR02168  552 VenlnaakKAIAFLKQNELGRVTFLP-LDSIKGTEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKAlsyllggvlvvdd 630

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1566 -NECAEMLKQKVEE----------------LTRQNNETKLMMQRIQAESENIVLEKQTIQQRCEALKIQADGFKDQLRST 1628
Cdd:TIGR02168  631 lDNALELAKKLRPGyrivtldgdlvrpggvITGGSAKTNSSILERRREIEELEEKIEELEEKIAELEKALAELRKELEEL 710

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1629 NEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQLQQAQ 1708
Cdd:TIGR02168  711 EEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQ 790

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1709 VQ--------------ELNNRLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFKQSAEEFRKKMEKLMESKVITENDISG 1774
Cdd:TIGR02168  791 IEqlkeelkalrealdELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEE 870

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1775 IRLDFVSLQQENSRAQENAKLCETN-------IKELERQLQQYREQMQQGQHMEANHYQKCQKLE---DELIAQKRE--- 1841
Cdd:TIGR02168  871 LESELEALLNERASLEEALALLRSEleelseeLRELESKRSELRRELEELREKLAQLELRLEGLEvriDNLQERLSEeys 950

                          810       820       830
                   ....*....|....*....|....*....|..
gi 4502443    1842 -----VENLKQKMDQQIKEHEHQLVLLQCEIQ 1868
Cdd:TIGR02168  951 ltleeAEALENKIEDDEEEARRRLKRLENKIK 982
SH3_10 pfam17902
SH3 domain; This entry represents an SH3 domain.
 550-616 5.19e-21

SH3 domain; This entry represents an SH3 domain.


Pssm-ID: 407754  Cd Length: 65  Bit Score: 88.47  E-value: 5.19e-21
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4502443     550 QLKPRNSdcPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVP 616
Cdd:pfam17902    1 PLKQRRS--PVTRPIPVKALCDYKQGEVTVEKGEECTLLDNSDREKWKVQTSSGVEKLVPSVCFLIP 65
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 1092-1845 5.04e-20

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 98.22  E-value: 5.04e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1092 IKFAGDSLKRLEEE-----EIKRCKETSEHGAYSDLLQRQKATVLENSKLTGKISELERMVAELKKQKSRVEEEL----- 1161
Cdd:TIGR02169  193 IDEKRQQLERLRRErekaeRYQALLKEKREYEGYELLKEKEALERQKEAIERQLASLEEELEKLTEEISELEKRLeeieq 272

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1162 ------PKVREAAENE--------------LRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLT 1221
Cdd:TIGR02169  273 lleelnKKIKDLGEEEqlrvkekigeleaeIASLERSIAEKERELEDAEERLAKLEAEIDKLLAEIEELEREIEEERKRR 352

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1222 IEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKLIKQMEKDLAfq 1301
Cdd:TIGR02169  353 DKLTEEYAELKEELEDLRAELEEVDKEFAETRDELKDYREKLEKLKREINELKRELDRLQEELQRLSEELADLNAAIA-- 430

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1302 kqVAEKQLKEKQKIELEARRKITEIQytcrenalpvcpitqatscravtglqqehdkQKAEELKQQVDeltaanrKAEQD 1381
Cdd:TIGR02169  431 --GIEAKINELEEEKEDKALEIKKQE-------------------------------WKLEQLAADLS-------KYEQE 470

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1382 MRELTYELNALQLEKTSSEEKARLLKDKLDETNNTLRCLKLELERKDQAEKGYSQQLRELGR---------------QLN 1446
Cdd:TIGR02169  471 LYDLKEEYDRVEKELSKLQRELAEAEAQARASEERVRGGRAVEEVLKASIQGVHGTVAQLGSvgeryataievaagnRLN 550

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1447 QTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKlQREVDRITRAHAVA------EKNIQHLNSQIHSFRDEKELERL 1520
Cdd:TIGR02169  551 NVVVEDDAVAKEAIELLKRRKAGRATFLPLNKMRDE-RRDLSILSEDGVIGfavdlvEFDPKYEPAFKYVFGDTLVVEDI 629

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1521 QICQRKSDHLK------EQFEKS------HEQLLQNIKAEKENNDKIQRLNEELEKSNECAEMLKQKVEELTRQNNETKL 1588
Cdd:TIGR02169  630 EAARRLMGKYRmvtlegELFEKSgamtggSRAPRGGILFSRSEPAELQRLRERLEGLKRELSSLQSELRRIENRLDELSQ 709

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1589 MMQRIQAESENIVLEKQTIQQRCEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQKCD 1668
Cdd:TIGR02169  710 ELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEIENVKSELKELEARIEELEEDLHKLEEALNDLEARLS 789

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1669 QQniiiqntkkEVRNLNAELNASKEEKRRgeqkvqlQQAQVQELNNRLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFK 1748
Cdd:TIGR02169  790 HS---------RIPEIQAELSKLEEEVSR-------IEARLREIEQKLNRLTLEKEYLEKEIQELQEQRIDLKEQIKSIE 853

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1749 QSAEEFRKKMEKLMESKVITENDISGIRLDFVSLQQENSRAQENAKLCETNIKELERQLQQYREQMQQGQHMEANHYQKC 1828
Cdd:TIGR02169  854 KEIENLNGKKEELEEELEELEAALRDLESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRLSELKAKLEALEEEL 933

                          810
                   ....*....|....*..
gi 4502443    1829 QKLEDELIAQKREVENL 1845
Cdd:TIGR02169  934 SEIEDPKGEDEEIPEEE 950
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1072-1763 2.55e-19

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 95.89  E-value: 2.55e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1072 QEFMDLRTRYTAL-VTLMTQYIKFAGDSLKRLEEEEIK---RCKET---------------SEHGAYSDLLQRQKATVLE 1132
Cdd:TIGR02168  213 ERYKELKAELRELeLALLVLRLEELREELEELQEELKEaeeELEELtaelqeleekleelrLEVSELEEEIEELQKELYA 292

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1133 nskLTGKISELERMVAELKKQKSRVEEELpkvrEAAENELRKQQRnvedislQKIRAESEAKQYRRELETIVREKEAAER 1212
Cdd:TIGR02168  293 ---LANEISRLEQQKQILRERLANLERQL----EELEAQLEELES-------KLDELAEELAELEEKLEELKEELESLEA 358

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1213 ELERVRQLTIEAEAKRAAVEENLLNFR-------NQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNE- 1284
Cdd:TIGR02168  359 ELEELEAELEELESRLEELEEQLETLRskvaqleLQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEAELKEl 438

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1285 --------EELLKLIKQMEkDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCR------------------------- 1331
Cdd:TIGR02168  439 qaeleeleEELEELQEELE-RLEEALEELREELEEAEQALDAAERELAQLQARLDslerlqenlegfsegvkallknqsg 517

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1332 ----------------------ENALP-----VCPITQATSCRAVTGLQQeHDKQKAE--ELKQQVDELTAANRkAEQDM 1382
Cdd:TIGR02168  518 lsgilgvlselisvdegyeaaiEAALGgrlqaVVVENLNAAKKAIAFLKQ-NELGRVTflPLDSIKGTEIQGND-REILK 595

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1383 RELTYELNALQLEKTSSE----------------------EKARLLKDKL--------------------DETNNTLRCL 1420
Cdd:TIGR02168  596 NIEGFLGVAKDLVKFDPKlrkalsyllggvlvvddldnalELAKKLRPGYrivtldgdlvrpggvitggsAKTNSSILER 675

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1421 KLELERKDQAEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKN 1500
Cdd:TIGR02168  676 RREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKE 755

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1501 IQHLNSQIHSFRD--EKELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEELEKSNECAEMLKQKVEE 1578
Cdd:TIGR02168  756 LTELEAEIEELEErlEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAA 835

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1579 LTRQNNETKLMMQRIQAESENIVLEKQTIQQRCEALKIQADGFKDQLRSTNEHLH-------KQTKTEQDFQRKIKCLEE 1651
Cdd:TIGR02168  836 TERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALAllrseleELSEELRELESKRSELRR 915

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1652 DLAKSQNLVSEFKQKCDQQNIIIQNTKKEVRNL-NAELNASKEEKRRGEQKVQLQQAQVQELNNRLKKVqDELHLKTIEE 1730
Cdd:TIGR02168  916 ELEELREKLAQLELRLEGLEVRIDNLQERLSEEySLTLEEAEALENKIEDDEEEARRRLKRLENKIKEL-GPVNLAAIEE 994

                          810       820       830
                   ....*....|....*....|....*....|....*....
gi 4502443    1731 qmthrkmvlFQEESGKF------KQSAEEFRKKMEKLME 1763
Cdd:TIGR02168  995 ---------YEELKERYdfltaqKEDLTEAKETLEEAIE 1024
SPEC cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members ...
 375-557 2.56e-19

Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; the repeats are independent folding units; tandem repeats are found in differing numbers and arrange in an antiparallel manner to form dimers; the repeats are defined by a characteristic tryptophan (W) residue in helix A and a leucine (L) at the carboxyl end of helix C and separated by a linker of 5 residues; two copies of the repeat are present here


Pssm-ID: 238103 [Multi-domain]  Cd Length: 213  Bit Score: 89.04  E-value: 2.56e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   375 LHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 454
Cdd:cd00176    2 LQQFLRDADELEAWLSEKEELLSSTDYGDDLESVEALLKKHEALEAELAAHEERVEALNELGEQLIEEGHPDAEEIQERL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   455 AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQrkySCDRSSSIHKLEDLVQESMEEKEELLQY 534
Cdd:cd00176   82 EELNQRWEELRELAEERRQRLEEALDLQQFFRDADDLEQWLEEKEAALA---SEDLGKDLESVEELLKKHKELEEELEAH 158

                        170       180
                 ....*....|....*....|...
gi 4502443   535 KSTIANLMGKAKTIIQLKPRNSD 557
Cdd:cd00176  159 EPRLKSLNELAEELLEEGHPDAD 181
PTZ00121 PTZ00121
MAEBL; Provisional
 1097-1800 3.07e-19

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 95.98  E-value: 3.07e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1097 DSLKRLEE----EEIKRCKETSEHGAYSDLLQRQKATVLENSKLTGKISELERMVAELKKQKSRVEEELPKVREAAENEL 1172
Cdd:PTZ00121 1125 EDARKAEEarkaEDARKAEEARKAEDAKRVEIARKAEDARKAEEARKAEDAKKAEAARKAEEVRKAEELRKAEDARKAEA 1204

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1173 RKQQRNVEDIS-LQKIRAESEAKQYRRELETIVREKEAAERELER-----------------VRQLTIEAEAKRAAVEEN 1234
Cdd:PTZ00121 1205 ARKAEEERKAEeARKAEDAKKAEAVKKAEEAKKDAEEAKKAEEERnneeirkfeearmahfaRRQAAIKAEEARKADELK 1284

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1235 LLNFRNQLEEntfTRRTLE----DHLKRKDLSLNDLEQQKNKLME------ELRRKRDNEEELLKLIKQMEKDLAFQKQV 1304
Cdd:PTZ00121 1285 KAEEKKKADE---AKKAEEkkkaDEAKKKAEEAKKADEAKKKAEEakkkadAAKKKAEEAKKAAEAAKAEAEAAADEAEA 1361

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1305 AEKQLKEKQKIELEARRKITEIQYTCRENAlpvcpitqatscravtglQQEHDKQKAEELKQQVDEL---TAANRKAEQD 1381
Cdd:PTZ00121 1362 AEEKAEAAEKKKEEAKKKADAAKKKAEEKK------------------KADEAKKKAEEDKKKADELkkaAAAKKKADEA 1423

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1382 MRELTYELNALQLEKTSSE-EKARLLKDKLDETNntlrclKLELERKDQAEKGYSQQLR---ELGRQLNQTTGKAEEAMQ 1457
Cdd:PTZ00121 1424 KKKAEEKKKADEAKKKAEEaKKADEAKKKAEEAK------KAEEAKKKAEEAKKADEAKkkaEEAKKADEAKKKAEEAKK 1497

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1458 EASDLKKIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFRDEKEL----------------ERLQ 1521
Cdd:PTZ00121 1498 KADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEELkkaeekkkaeeakkaeEDKN 1577

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1522 ICQRKSDHLKEQFEKSHEQLLQNIKAEKENN-DKIQRLNEELEKSNEC--AEMLKQKVEELTRQNNETKLMMQRIQAESE 1598
Cdd:PTZ00121 1578 MALRKAEEAKKAEEARIEEVMKLYEEEKKMKaEEAKKAEEAKIKAEELkkAEEEKKKVEQLKKKEAEEKKKAEELKKAEE 1657

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1599 NIVLEKQTIQQRCEALKIQAdgfkDQLRSTNEHLHK---QTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQKCDQQNIIIQ 1675
Cdd:PTZ00121 1658 ENKIKAAEEAKKAEEDKKKA----EEAKKAEEDEKKaaeALKKEAEEAKKAEELKKKEAEEKKKAEELKKAEEENKIKAE 1733

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1676 NTKKEvrnlnaelnaSKEEKRRGEQ--KVQLQQAQVQELNNRLKKVQDELHLK---TIEEQMTHRKMVLFQEESGKFKQS 1750
Cdd:PTZ00121 1734 EAKKE----------AEEDKKKAEEakKDEEEKKKIAHLKKEEEKKAEEIRKEkeaVIEEELDEEDEKRRMEVDKKIKDI 1803

                         730       740       750       760       770
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 4502443   1751 AEEFRKKMEKLMESKVIT----ENDISGIR--LDFVSLQQENSRAQENAKLCETNI 1800
Cdd:PTZ00121 1804 FDNFANIIEGGKEGNLVIndskEMEDSAIKevADSKNMQLEEADAFEKHKFNKNNE 1859
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1194-1875 2.93e-18

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 92.43  E-value: 2.93e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1194 KQYRRELEtivREKEAAERELERV--------RQL-TIEAEAKRAaveENLLNFRNQLEEntftrrtledhlKRKDLSLN 1264
Cdd:TIGR02168  171 KERRKETE---RKLERTRENLDRLedilneleRQLkSLERQAEKA---ERYKELKAELRE------------LELALLVL 232

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1265 DLEqqknklmeELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQat 1344
Cdd:TIGR02168  233 RLE--------ELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQ-- 302

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1345 scravtglQQEHDKQKAEELKQQVDELTAANRKAEQDMRELTYELNALQLEKTSSEEKARLLKDKLDETNNTLRCLKLEL 1424
Cdd:TIGR02168  303 --------QKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRL 374

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1425 ERKDQAEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLKKIKRNYQLELESLN-----HEKGKLQREVDRITRAHAVAEK 1499
Cdd:TIGR02168  375 EELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLkkleeAELKELQAELEELEEELEELQE 454

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1500 NIQHLNSQIHSFRDEKELERLQICQRKSDH------------LKEQFEKSHEQLLQNIKAEKENNDKIQRL------NEE 1561
Cdd:TIGR02168  455 ELERLEEALEELREELEEAEQALDAAERELaqlqarldslerLQENLEGFSEGVKALLKNQSGLSGILGVLselisvDEG 534

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1562 LEKSNECA-------------EMLKQKVEELtRQNNETKLMM--------QRIQAESENIVLEKQTIQQRCEALKIQADG 1620
Cdd:TIGR02168  535 YEAAIEAAlggrlqavvvenlNAAKKAIAFL-KQNELGRVTFlpldsikgTEIQGNDREILKNIEGFLGVAKDLVKFDPK 613

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1621 FK-------------DQLRSTNEhLHKQTKTEQDF----------------------------QRKIKCLEEDLAKSQNL 1659
Cdd:TIGR02168  614 LRkalsyllggvlvvDDLDNALE-LAKKLRPGYRIvtldgdlvrpggvitggsaktnssilerRREIEELEEKIEELEEK 692

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1660 VSEFKQKCDQQNIIIQNTKKEVRNLNAE-------LNASKEEKRRGEQKVQLQQAQVQELNNRLKKVQDELHLKTIEEQM 1732
Cdd:TIGR02168  693 IAELEKALAELRKELEELEEELEQLRKEleelsrqISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEE 772

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1733 THRKMVLFQEESGKFKQSAEEFRKKMEKLMESKVITENDISGIRLDFVSLQQENSRAQENAKLCETNIKELERQLQQYRE 1812
Cdd:TIGR02168  773 AEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSE 852

                          730       740       750       760       770       780
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 4502443    1813 QMQQGQH-MEanhyqKCQKLEDELIAQKREVENLKQKMDQQIKEHEHQLVLLQCEIQKKSTAKD 1875
Cdd:TIGR02168  853 DIESLAAeIE-----ELEELIEELESELEALLNERASLEEALALLRSELEELSEELRELESKRS 911
PTZ00121 PTZ00121
MAEBL; Provisional
 1107-1857 3.79e-18

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 92.51  E-value: 3.79e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1107 IKRCKETSEHGAYSDLLQRQ-----------------KATVLENSKLTGKISELERMVAELKKQKSRVEEELPKVREAAE 1169
Cdd:PTZ00121 1026 IEKIEELTEYGNNDDVLKEKdiidedidgnhegkaeaKAHVGQDEGLKPSYKDFDFDAKEDNRADEATEEAFGKAEEAKK 1105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1170 NELRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLTIEAEAKRAAVEENLLNFRNQLEENTFTR 1249
Cdd:PTZ00121 1106 TETGKAEEARKAEEAKKKAEDARKAEEARKAEDARKAEEARKAEDAKRVEIARKAEDARKAEEARKAEDAKKAEAARKAE 1185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1250 RTLEDHLKRKDLSLNDLEQQKN----KLMEELRRKRDNEE-ELLKLIKQMEKDlafqKQVAEKQLKEKQKIELEARRKIT 1324
Cdd:PTZ00121 1186 EVRKAEELRKAEDARKAEAARKaeeeRKAEEARKAEDAKKaEAVKKAEEAKKD----AEEAKKAEEERNNEEIRKFEEAR 1261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1325 EIQYTCRENALpvcpitQATSCRAVTGLQQEHDKQKAEELK--QQVDELTAANRKAEQDMReltyelnALQLEKTSSE-- 1400
Cdd:PTZ00121 1262 MAHFARRQAAI------KAEEARKADELKKAEEKKKADEAKkaEEKKKADEAKKKAEEAKK-------ADEAKKKAEEak 1328

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1401 EKARLLKDKLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLKKIKrnyqlELESLNHEK 1480
Cdd:PTZ00121 1329 KKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKAD-----EAKKKAEED 1403

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1481 GKLQREVDRitraHAVAEKNIQHLNSQIHSFRDEKELERLQICQRKSDHLKEQFEKSHEQLLQNIKA-EKENNDKIQRLN 1559
Cdd:PTZ00121 1404 KKKADELKK----AAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAeEAKKADEAKKKA 1479

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1560 EELEKSNEC---AEMLKQKVEELTRQNNETKLMMQRIQAESENIVLEKQTIQQRC---EALKIQADGFKDQLRSTNEHLH 1633
Cdd:PTZ00121 1480 EEAKKADEAkkkAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKkadEAKKAEEKKKADELKKAEELKK 1559

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1634 KQTKTEQDFQRKikcLEEDLAKSQNLVSEFKQkcdqqniIIQNTKKEVRNLNAELNASKEEKRRGEQKVQLQQAQVQELN 1713
Cdd:PTZ00121 1560 AEEKKKAEEAKK---AEEDKNMALRKAEEAKK-------AEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAE 1629

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1714 NRLKKVqdELHLKTIEEQMTHRKMVLFQEESGKFKqsAEEFRKKMEklmeskvitendisgirldfvslqqENSRAQENA 1793
Cdd:PTZ00121 1630 EEKKKV--EQLKKKEAEEKKKAEELKKAEEENKIK--AAEEAKKAE-------------------------EDKKKAEEA 1680

                         730       740       750       760       770       780
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4502443   1794 KLCETNIKELERQLQQYREQMQQGQHM---EANHYQKCQKLEDELIAQKREVENLKQKMDQQIKEHE 1857
Cdd:PTZ00121 1681 KKAEEDEKKAAEALKKEAEEAKKAEELkkkEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDKKKAE 1747
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1135-1493 2.79e-17

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 89.35  E-value: 2.79e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1135 KLTGKISELERMVAELKKQKSRVEEELPKVREAAENELRKQQRNVEDISLQKIRAESEAKQYRRELETIVR---EKEAAE 1211
Cdd:TIGR02168  688 ELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTEleaEIEELE 767

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1212 RELERVRQLTIEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKLI 1291
Cdd:TIGR02168  768 ERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQI 847

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1292 KQMEKDLAFqkqvAEKQLKEKQKIELEARRKITEiqytcrenalpvcpitqATSCRAVTGLQQEHDKQKAEELKQQVDEL 1371
Cdd:TIGR02168  848 EELSEDIES----LAAEIEELEELIEELESELEA-----------------LLNERASLEEALALLRSELEELSEELREL 906

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1372 TAANRKAEQDMRELTYELNALQLEKTSSEEKARLLKDKLDETNNTLRCLKLELERKDQAEKGYSQ-QLRELGRQLNQTTG 1450
Cdd:TIGR02168  907 ESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQERLSEEYSLTLEEAEALENKIEDDEEEARrRLKRLENKIKELGP 986

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*.
gi 4502443    1451 KAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQ---REVDRITRA 1493
Cdd:TIGR02168  987 VNLAAIEEYEELKERYDFLTAQKEDLTEAKETLEeaiEEIDREARE 1032
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 1234-1875 9.06e-17

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 87.00  E-value: 9.06e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1234 NLLNFRNQLEENTFTR-RTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEK 1312
Cdd:TIGR04523   26 NIANKQDTEEKQLEKKlKTIKNELKNKEKELKNLDKNLNKDEEKINNSNNKIKILEQQIKDLNDKLKKNKDKINKLNSDL 105

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1313 QKIELEARRKITEIqytcrenalpvcpitqatscravtgLQQEHDKQKAEELKQQVDELTAAN----RKAEQDMRELTYE 1388
Cdd:TIGR04523  106 SKINSEIKNDKEQK-------------------------NKLEVELNKLEKQKKENKKNIDKFlteiKKKEKELEKLNNK 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1389 LNALQLEKTSSEEKARLLKDKLDETNNTLRCLKLE----------LERKDQAEKGYSQQLRELGRQLNQTTGKAEEAMQE 1458
Cdd:TIGR04523  161 YNDLKKQKEELENELNLLEKEKLNIQKNIDKIKNKllklelllsnLKKKIQKNKSLESQISELKKQNNQLKDNIEKKQQE 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1459 ASDLKKIKRNYQLEL----ESLNHEKGKL---QREVDRITRAHAVAEKNIQHLNSQIHSFRDEKElerlqicQRKSDHLK 1531
Cdd:TIGR04523  241 INEKTTEISNTQTQLnqlkDEQNKIKKQLsekQKELEQNNKKIKELEKQLNQLKSEISDLNNQKE-------QDWNKELK 313

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1532 EQFEKSHEQLLQNIKAEKENNDKIQRLNEELEKsnecaemLKQKVEELTRQNNETKLMMQRIQAESENIVLEKQTIQQRC 1611
Cdd:TIGR04523  314 SELKNQEKKLEEIQNQISQNNKIISQLNEQISQ-------LKKELTNSESENSEKQRELEEKQNEIEKLKKENQSYKQEI 386

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1612 EALKIQADGFKDQLRstnehlhKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLNAELNAS 1691
Cdd:TIGR04523  387 KNLESQINDLESKIQ-------NQEKLNQQKDEQIKKLQQEKELLEKEIERLKETIIKNNSEIKDLTNQDSVKELIIKNL 459

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1692 KEEKRRGEQKVQLQQAQVQELNNRLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFKQSAEEFRKKMEKLMESKVITEND 1771
Cdd:TIGR04523  460 DNTRESLETQLKVLSRSINKIKQNLEQKQKELKSKEKELKKLNEEKKELEEKVKDLTKKISSLKEKIEKLESEKKEKESK 539

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1772 ISGIRLDFVSLQQENSRaqenaklceTNIKELERQLQQYREQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQKMDQ 1851
Cdd:TIGR04523  540 ISDLEDELNKDDFELKK---------ENLEKEIDEKNKEIEELKQTQKSLKKKQEEKQELIDQKEKEKKDLIKEIEEKEK 610

                          650       660
                   ....*....|....*....|....
gi 4502443    1852 QIKEHEHQLVLLQCEIQKKSTAKD 1875
Cdd:TIGR04523  611 KISSLEKELEKAKKENEKLSSIIK 634
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1140-1718 9.26e-17

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 87.30  E-value: 9.26e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1140 ISELERMVAELKKQKSR------VEEELpKVREAAE--NELRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAE 1211
Cdd:COG1196  195 LGELERQLEPLERQAEKaeryreLKEEL-KELEAELllLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELR 273

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1212 RELERVRQLTIEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKLI 1291
Cdd:COG1196  274 LELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEEL 353

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1292 KQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQytcrenalpvcpitQATSCRAVTGLQQEHDKQKAEELKQQVDEL 1371
Cdd:COG1196  354 EEAEAELAEAEEALLEAEAELAEAEEELEELAEELL--------------EALRAAAELAAQLEELEEAEEALLERLERL 419

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1372 TAANRKAEQDMREltyELNALQLEKTSSEEKARLLKDKLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLNQTTGK 1451
Cdd:COG1196  420 EEELEELEEALAE---LEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLL 496

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1452 AEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFRDEKELERL----------- 1520
Cdd:COG1196  497 LEAEADYEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAALEAALAAALQNIVVEDDEVAAAAIEYlkaakagratf 576

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1521 ----QICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEELEKSN---ECAEMLKQKVEELTRQNNETKLMMQRI 1593
Cdd:COG1196  577 lpldKIRARAALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTlvaARLEAALRRAVTLAGRLREVTLEGEGG 656

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1594 QAESENIVLEKQTIQQRCEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQkcdQQNII 1673
Cdd:COG1196  657 SAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEE---QLEAE 733

                        570       580       590       600
                 ....*....|....*....|....*....|....*....|....*
gi 4502443  1674 IQNTKKEVRNLNAELNASKEEKRRGEQKVQLQQAQVQELNNRLKK 1718
Cdd:COG1196  734 REELLEELLEEEELLEEEALEELPEPPDLEELERELERLEREIEA 778
SPEC cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members ...
 282-477 9.54e-17

Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; the repeats are independent folding units; tandem repeats are found in differing numbers and arrange in an antiparallel manner to form dimers; the repeats are defined by a characteristic tryptophan (W) residue in helix A and a leucine (L) at the carboxyl end of helix C and separated by a linker of 5 residues; two copies of the repeat are present here


Pssm-ID: 238103 [Multi-domain]  Cd Length: 213  Bit Score: 81.34  E-value: 9.54e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   282 VQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISE---IQMTAPLKLTYAEKLHRLESQY 358
Cdd:cd00176    9 ADELEAWLSEKEELLSSTDYGDDLESVEALLKKHEALEAELAAHEERVEALNELGeqlIEEGHPDAEEIQERLEELNQRW 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   359 AKLLNTSRNQERHLDT---LHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEI 435
Cdd:cd00176   89 EELRELAEERRQRLEEaldLQQFFRDADDLEQWLEEKEAALASEDLGKDLESVEELLKKHKELEEELEAHEPRLKSLNEL 168

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 4502443   436 AEQLLLENHP-ARLTIEAYRAAMQTQWSWILQLCQCVEQHIKE 477
Cdd:cd00176  169 AEELLEEGHPdADEEIEEKLEELNERWEELLELAEERQKKLEE 211
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 912-1870 1.74e-16

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 86.64  E-value: 1.74e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443     912 KAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQ 991
Cdd:TIGR00606  186 KALETLRQVRQTQGQKVQEHQMELKYLKQYKEKACEIRDQITSKEAQLESSREIVKSYENELDPLKNRLKEIEHNLSKIM 265

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443     992 ENQPENSKTLATQLNQQKmLVSEIEMKQSKM-----DECQKYAEQYSATVKDYElqtmtyRAMVDSQQKSpvkrRRMQSS 1066
Cdd:TIGR00606  266 KLDNEIKALKSRKKQMEK-DNSELELKMEKVfqgtdEQLNDLYHNHQRTVREKE------RELVDCQREL----EKLNKE 334

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1067 ADLIIQEFMDLRTR--YTALVTLMTQYIKFAGDSLKrlEEEEIKRCKETSEHGAYSDLlQRQKATVLENSKLTGKISELE 1144
Cdd:TIGR00606  335 RRLLNQEKTELLVEqgRLQLQADRHQEHIRARDSLI--QSLATRLELDGFERGPFSER-QIKNFHTLVIERQEDEAKTAA 411

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1145 RMVAELKKQKSRVEEELPKVREaaenELRKQQRNVEDISLQKIRAESEAKQYRRELETIvrekEAAERELERVRQLTIEA 1224
Cdd:TIGR00606  412 QLCADLQSKERLKQEQADEIRD----EKKGLGRTIELKKEILEKKQEELKFVIKELQQL----EGSSDRILELDQELRKA 483

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1225 EAKRAAVEENllnfrnqleENTFTRRTLEDHLKRKDLslnDLEQQKNKLMEELRRKRDNEEELlkliKQMEkdlafqkQV 1304
Cdd:TIGR00606  484 ERELSKAEKN---------SLTETLKKEVKSLQNEKA---DLDRKLRKLDQEMEQLNHHTTTR----TQME-------ML 540

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1305 AEKQLKEKQKIelearRKITEIQYTCRENALPVCPITQATScravtglQQEHDKQKaeELKQQVDELTAANR---KAEQD 1381
Cdd:TIGR00606  541 TKDKMDKDEQI-----RKIKSRHSDELTSLLGYFPNKKQLE-------DWLHSKSK--EINQTRDRLAKLNKelaSLEQN 606

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1382 MRELTYELNALQLEKTSSEEK------ARLLKDKLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQ------LNQTT 1449
Cdd:TIGR00606  607 KNHINNELESKEEQLSSYEDKlfdvcgSQDEESDLERLKEEIEKSSKQRAMLAGATAVYSQFITQLTDEnqsccpVCQRV 686

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1450 GKAEEAMQE-ASDLKKIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFRdekelERLQICQRKSD 1528
Cdd:TIGR00606  687 FQTEAELQEfISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLAPGRQSIIDLKEKEIPELR-----NKLQKVNRDIQ 761

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1529 HLKEQFEKsHEQLLQNIKAEKENNDK-------IQRLNEELEKSNECAEMLKQKVE--ELTRQNNETKLMMQRIQAESEN 1599
Cdd:TIGR00606  762 RLKNDIEE-QETLLGTIMPEEESAKVcltdvtiMERFQMELKDVERKIAQQAAKLQgsDLDRTVQQVNQEKQEKQHELDT 840

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1600 IVLEKQTIQQRCEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQKCDQQNIIIQNTKK 1679
Cdd:TIGR00606  841 VVSKIELNRKLIQDQQEQIQHLKSKTNELKSEKLQIGTNLQRRQQFEEQLVELSTEVQSLIREIKDAKEQDSPLETFLEK 920

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1680 EVRNLNAELNASKEEKRRGEQKVQLQQAQVQELNNRLKKVQdelhlKTIEEQMTHRKMVLfQEESGKFKQSAEEFRKKME 1759
Cdd:TIGR00606  921 DQQEKEELISSKETSNKKAQDKVNDIKEKVKNIHGYMKDIE-----NKIQDGKDDYLKQK-ETELNTVNAQLEECEKHQE 994

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1760 KLmeskvitENDISGIRLDFVSLQQENSRAQENAKL--CETNIKELERQLQQYREQMQQGQHMEANhyQKCQKLEDELia 1837
Cdd:TIGR00606  995 KI-------NEDMRLMRQDIDTQKIQERWLQDNLTLrkRENELKEVEEELKQHLKEMGQMQVLQMK--QEHQKLEENI-- 1063

                          970       980       990
                   ....*....|....*....|....*....|...
gi 4502443    1838 qkREVENLKQKMDQQIKEHEHQLVLLQCEIQKK 1870
Cdd:TIGR00606 1064 --DLIKRNHVLALGRQKGYEKEIKHFKKELREP 1094
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 935-1721 7.21e-16

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 84.78  E-value: 7.21e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443     935 KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYY-RDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVS 1013
Cdd:pfam15921   73 KEHIERVLEEYSHQVKDLQRRLNESNELHEKQKFYlRQSVIDLQTKLQEMQMERDAMADIRRRESQSQEDLRNQLQNTVH 152

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1014 EIE----MKQSKMDECQKYAEQYSATVKDYELQTMTYRA-MVDSQQKSPVKRRRMQSSADLiiqEFMDLRTRYTALVTLM 1088
Cdd:pfam15921  153 ELEaakcLKEDMLEDSNTQIEQLRKMMLSHEGVLQEIRSiLVDFEEASGKKIYEHDSMSTM---HFRSLGSAISKILREL 229

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1089 TQYIKFAGDSLKRLEEEeIKRCKETSEHGAYSDLLQRQKATVLENSKLTGKISELERMVAELKKQKSRVEEELPKVREAA 1168
Cdd:pfam15921  230 DTEISYLKGRIFPVEDQ-LEALKSESQNKIELLLQQHQDRIEQLISEHEVEITGLTEKASSARSQANSIQSQLEIIQEQA 308

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1169 ENELRKQQRNVEDIslqkiraESEAKQYRRELETIVREKEAAERELERvrQLTI------EAEAKRAAVEENLLNFRNQL 1242
Cdd:pfam15921  309 RNQNSMYMRQLSDL-------ESTVSQLRSELREAKRMYEDKIEELEK--QLVLanseltEARTERDQFSQESGNLDDQL 379

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1243 EentftrRTLED-HLKRKDLSLndlEQQKNKLMEElrRKRDNEEELLKLIKQMEkDLAFQKQVAEKQLKE-KQKIELEAR 1320
Cdd:pfam15921  380 Q------KLLADlHKREKELSL---EKEQNKRLWD--RDTGNSITIDHLRRELD-DRNMEVQRLEALLKAmKSECQGQME 447

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1321 RKITEIQytcrenalpvcpiTQATSCRAVTGLQQEHDKQKaEELKQQVDELTAANRKAEQDMRELTYELNALQ-----LE 1395
Cdd:pfam15921  448 RQMAAIQ-------------GKNESLEKVSSLTAQLESTK-EMLRKVVEELTAKKMTLESSERTVSDLTASLQekeraIE 513

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1396 KTSSE------------EKARLLKDKLDETNNT---LRCLKLELERKDQAEKGYSQQLRELgRQLNQTTGKAEEAMQ-EA 1459
Cdd:pfam15921  514 ATNAEitklrsrvdlklQELQHLKNEGDHLRNVqteCEALKLQMAEKDKVIEILRQQIENM-TQLVGQHGRTAGAMQvEK 592

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1460 SDLKKIKRNYQLELESLNHEKGKlqrevdritrahavAEKNIQHLNSQIHSFrdekELERLQICQRKSDHLK--EQFEKS 1537
Cdd:pfam15921  593 AQLEKEINDRRLELQEFKILKDK--------------KDAKIRELEARVSDL----ELEKVKLVNAGSERLRavKDIKQE 654

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1538 HEQLLQNIKAEKennDKIQRLNEELE--KSNecaemLKQKVEELTRQNNETKLMMQRIQAESENIVLEKQTIQ-QRCEAL 1614
Cdd:pfam15921  655 RDQLLNEVKTSR---NELNSLSEDYEvlKRN-----FRNKSEEMETTTNKLKMQLKSAQSELEQTRNTLKSMEgSDGHAM 726

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1615 KIqADGFKDQLRSTNEHLHKqtkteqdFQRKIKCLEEDLA---KSQNLVSEFKQKCDQQniiIQNTKKEVRNLNAELNAS 1691
Cdd:pfam15921  727 KV-AMGMQKQITAKRGQIDA-------LQSKIQFLEEAMTnanKEKHFLKEEKNKLSQE---LSTVATEKNKMAGELEVL 795

                          810       820       830
                   ....*....|....*....|....*....|
gi 4502443    1692 KEEKRRGEQKVQLQQAQVQELNNRLKKVQD 1721
Cdd:pfam15921  796 RSQERRLKEKVANMEVALDKASLQFAECQD 825
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 1165-1860 3.23e-15

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 82.71  E-value: 3.23e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1165 REAAENELRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLTIE---AEAKRAAVEENLLNFRNQ 1241
Cdd:pfam02463  172 KEALKKLIEETENLAELIIDLEELKLQELKLKEQAKKALEYYQLKEKLELEEEYLLYLDylkLNEERIDLLQELLRDEQE 251

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1242 LEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLK----LIKQMEKDLAFQKQVAEKQLKEKQKIEL 1317
Cdd:pfam02463  252 EIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEEELKLLAKEEEELKsellKLERRKVDDEEKLKESEKEKKKAEKELK 331

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1318 EARRKITEIQytcRENALPVCPITQATSCRAVTGLQQEHDKQKAEELKQQVDELTAANRKAEQDMRELTYELNALQLEKT 1397
Cdd:pfam02463  332 KEKEEIEELE---KELKELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLESERLSSAAKLKEEELELKSEEEKEAQ 408

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1398 SSEEKARLLKDKLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLNQTTGKAEEAMQEASDL----KKIKRNYQLEL 1473
Cdd:pfam02463  409 LLLELARQLEDLLKEEKKEELEILEEEEESIELKQGKLTEEKEELEKQELKLLKDELELKKSEDLlketQLVKLQEQLEL 488

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1474 ESL--------------------------NHEKGKLQREVDRITRAHAVAEK-------NIQHLNSQIHSFRDEKELERL 1520
Cdd:pfam02463  489 LLSrqkleersqkeskarsglkvllalikDGVGGRIISAHGRLGDLGVAVENykvaistAVIVEVSATADEVEERQKLVR 568

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1521 QICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEE-------LEKSNECAEMLKQKVEELTRQNNETKLMMQRI 1593
Cdd:pfam02463  569 ALTELPLGARKLRLLIPKLKLPLKSIAVLEIDPILNLAQLDkatleadEDDKRAKVVEGILKDTELTKLKESAKAKESGL 648

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1594 QAESE-----------NIVLEKQTIQQRCEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNlvSE 1662
Cdd:pfam02463  649 RKGVSleeglaeksevKASLSELTKELLEIQELQEKAESELAKEEILRRQLEIKKKEQREKEELKKLKLEAEELLA--DR 726

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1663 FKQKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQK-----VQLQQAQVQELNNRLKKVQDELHLKTIEEQMTHRKM 1737
Cdd:pfam02463  727 VQEAQDKINEELKLLKQKIDEEEEEEEKSRLKKEEKEEEkselsLKEKELAEEREKTEKLKVEEEKEEKLKAQEEELRAL 806

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1738 VLFQEESGKFKQSAEEFRKKMEKLMESKVITENDISGIRL-DFVSLQQENSRAQEN-AKLCETNIKELERQLQQYREQMQ 1815
Cdd:pfam02463  807 EEELKEEAELLEEEQLLIEQEEKIKEEELEELALELKEEQkLEKLAEEELERLEEEiTKEELLQELLLKEEELEEQKLKD 886

                          730       740       750       760
                   ....*....|....*....|....*....|....*....|....*
gi 4502443    1816 QGQHMEANHYQKcQKLEDELIAQKREVENLKQKMDQQIKEHEHQL 1860
Cdd:pfam02463  887 ELESKEEKEKEE-KKELEEESQKLNLLEEKENEIEERIKEEAEIL 930
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1169-1562 5.95e-15

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 81.64  E-value: 5.95e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1169 ENELRKQQRNVEDISLQKIRAESEAKQYRRELETIvrekeaaERELERVRQLTIEAEAKRAAVEENLLNFRNQLEENTFT 1248
Cdd:TIGR02168  676 RREIEELEEKIEELEEKIAELEKALAELRKELEEL-------EEELEQLRKELEELSRQISALRKDLARLEAEVEQLEER 748

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1249 RRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKLIKQMEKDLafqkQVAEKQLKEKQKIELEARRKITEIQY 1328
Cdd:TIGR02168  749 IAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEEL----KALREALDELRAELTLLNEEAANLRE 824

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1329 TCRenalpvcpitQATSCRAVTGLQQEHDKQKAEELKQQVDELTAANRKAEQDMRELTYELNALQLEKTSSEEKARLLKD 1408
Cdd:TIGR02168  825 RLE----------SLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRS 894

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1409 KLDETNNTLRclklELERKDQAEKGYSQQLRELGRQLNQTTGKAEeaMQEASDLKKIKRNYQLELE-------SLNHEKG 1481
Cdd:TIGR02168  895 ELEELSEELR----ELESKRSELRRELEELREKLAQLELRLEGLE--VRIDNLQERLSEEYSLTLEeaealenKIEDDEE 968

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1482 KLQREVDRITRahavAEKNIQHLN-SQIHSFRDEKElerlqicqRKsDHLKEQFE---KSHEQLLQNIK-----AEKENN 1552
Cdd:TIGR02168  969 EARRRLKRLEN----KIKELGPVNlAAIEEYEELKE--------RY-DFLTAQKEdltEAKETLEEAIEeidreARERFK 1035

                          410
                   ....*....|
gi 4502443    1553 DKIQRLNEEL 1562
Cdd:TIGR02168 1036 DTFDQVNENF 1045
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 762-1583 9.39e-14

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 77.79  E-value: 9.39e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443     762 RQIRTPLERDDLHESVFRITEqekLKKELERLKDDLGTITNKCEEFFSQAAAS-SSVPTLRSELNVVlqnmnqvysmsST 840
Cdd:TIGR02168  216 KELKAELRELELALLVLRLEE---LREELEELQEELKEAEEELEELTAELQELeEKLEELRLEVSEL-----------EE 281

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443     841 YIDKLKTVNLVLKNTQAaealvKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEM 920
Cdd:TIGR02168  282 EIEELQKELYALANEIS-----RLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESL 356

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443     921 FKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDD----WIQQVETTQRKIQENQpe 996
Cdd:TIGR02168  357 EAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDrrerLQQEIEELLKKLEEAE-- 434

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443     997 nSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMD 1076
Cdd:TIGR02168  435 -LKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGVKALLK 513

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1077 LRTRYTALVTLMTQYIKFA-----------GDSLKRLEEEEIKRCKETSEHGAYSDLlqrQKATVLENSKLTG-KISELE 1144
Cdd:TIGR02168  514 NQSGLSGILGVLSELISVDegyeaaieaalGGRLQAVVVENLNAAKKAIAFLKQNEL---GRVTFLPLDSIKGtEIQGND 590

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1145 RMVAELKKQKSRVEEELPKVREAAE---NELRKQQRNVEDISlqkiRAESEAKQYRRElETIVrekeAAERELERVRQLT 1221
Cdd:TIGR02168  591 REILKNIEGFLGVAKDLVKFDPKLRkalSYLLGGVLVVDDLD----NALELAKKLRPG-YRIV----TLDGDLVRPGGVI 661

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1222 IEAEAKRAAveeNLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKLIKQMEKDLAFQ 1301
Cdd:TIGR02168  662 TGGSAKTNS---SILERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARL 738

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1302 KQVAEKQLKEKQKIELEARRKITEIqytcrenalpvcpiTQATSCRAVTGLQQEHDKQKAEELKQQVDELTAANRKAEQD 1381
Cdd:TIGR02168  739 EAEVEQLEERIAQLSKELTELEAEI--------------EELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREA 804

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1382 MRELTYELNALQLEKTSSEEKARLLKDKLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLnqttgkaEEAMQEASD 1461
Cdd:TIGR02168  805 LDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELI-------EELESELEA 877

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1462 LKKIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFRdekelERLQICQRKSDHLKEQFEKSHEQL 1541
Cdd:TIGR02168  878 LLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLE-----LRLEGLEVRIDNLQERLSEEYSLT 952

                          810       820       830       840
                   ....*....|....*....|....*....|....*....|...
gi 4502443    1542 LQNIKAEKENND-KIQRLNEELEKsnecaemLKQKVEELTRQN 1583
Cdd:TIGR02168  953 LEEAEALENKIEdDEEEARRRLKR-------LENKIKELGPVN 988
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1223-1851 1.24e-13

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 77.28  E-value: 1.24e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1223 EAEAKRAAVEENLlnfrnqleentfTRrtLEDHLKRKDLSLNDLEQQKNK------LMEELRRkRDNEEELLKLikqmek 1296
Cdd:COG1196  176 EAERKLEATEENL------------ER--LEDILGELERQLEPLERQAEKaeryreLKEELKE-LEAELLLLKL------ 234

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1297 dlafqkQVAEKQLKEKQKIELEARRKITEIQytcrenalpvcpitqatscravtgLQQEHDKQKAEELKQQVDELTAANR 1376
Cdd:COG1196  235 ------RELEAELEELEAELEELEAELEELE------------------------AELAELEAELEELRLELEELELELE 284

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1377 KAEQDMRELTYELNALQLEKTSSEEKARLLKDKLDEtnntlrcLKLELERKDQAEKGYSQQLRELGRQLNQTTGKAEEAM 1456
Cdd:COG1196  285 EAQAEEYELLAELARLEQDIARLEERRRELEERLEE-------LEEELAELEEELEELEEELEELEEELEEAEEELEEAE 357

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1457 QEASDLKKIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFRDEKE---------LERLQICQRKS 1527
Cdd:COG1196  358 AELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLErleeeleelEEALAELEEEE 437

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1528 DHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEELEKSNECAEMLKQKVEELTRQNNETKLMMQRIQAESENIVLEKQTI 1607
Cdd:COG1196  438 EEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLA 517

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1608 QQR--CEALKIQADGFK-----DQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLV--SEFKQKCDQQNIIIQNTK 1678
Cdd:COG1196  518 GLRglAGAVAVLIGVEAayeaaLEAALAAALQNIVVEDDEVAAAAIEYLKAAKAGRATFLplDKIRARAALAAALARGAI 597

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1679 KEVRNLNAELNASKEEKRRGEQKVQLQQAQVQELNN----RLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFKQSAEEF 1754
Cdd:COG1196  598 GAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEaalrRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEA 677

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1755 RKKMEKLMESKVITENDISGIRLDFVSLQQENSRAQENAKLCETNIKELERQLQQYREQMQQGQHMEANHYQKCQKLEDE 1834
Cdd:COG1196  678 EAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELP 757

                        650       660
                 ....*....|....*....|.
gi 4502443  1835 LI----AQKREVENLKQKMDQ 1851
Cdd:COG1196  758 EPpdleELERELERLEREIEA 778
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 1179-1849 1.39e-13

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 77.08  E-value: 1.39e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1179 VEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLtieAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKR 1258
Cdd:pfam15921   59 VELDSPRKIIAYPGKEHIERVLEEYSHQVKDLQRRLNESNEL---HEKQKFYLRQSVIDLQTKLQEMQMERDAMADIRRR 135

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1259 KDLSLNDLEQQKNKLMEELRRKRDNEEELLK----LIKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEiqytcrENA 1334
Cdd:pfam15921  136 ESQSQEDLRNQLQNTVHELEAAKCLKEDMLEdsntQIEQLRKMMLSHEGVLQEIRSILVDFEEASGKKIYE------HDS 209

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1335 LPVCPITQATScrAVTGLQQEHDKQkAEELKQQV----DELTAANRKAEQDMrELTYELNALQLEKTSSEEKARL--LKD 1408
Cdd:pfam15921  210 MSTMHFRSLGS--AISKILRELDTE-ISYLKGRIfpveDQLEALKSESQNKI-ELLLQQHQDRIEQLISEHEVEItgLTE 285

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1409 KLDETNNTLRCLKLELE-RKDQAEKGYSQQLRELGrQLNQTTGkaeeamQEASDLKKIKRNYQLELESL-------NHEK 1480
Cdd:pfam15921  286 KASSARSQANSIQSQLEiIQEQARNQNSMYMRQLS-DLESTVS------QLRSELREAKRMYEDKIEELekqlvlaNSEL 358

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1481 GKLQREVDRITRAHAVAEKNIQHLNSQIHSFRDEKELERLQ---ICQRKS------DHLKEQFEKSH------EQLLQNI 1545
Cdd:pfam15921  359 TEARTERDQFSQESGNLDDQLQKLLADLHKREKELSLEKEQnkrLWDRDTgnsitiDHLRRELDDRNmevqrlEALLKAM 438

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1546 KAE-----KENNDKIQRLNEELEKSNECA-------EMLKQKVEELTRQnnetKLMMQRIQAESENIVLEKQTIQQRCEA 1613
Cdd:pfam15921  439 KSEcqgqmERQMAAIQGKNESLEKVSSLTaqlestkEMLRKVVEELTAK----KMTLESSERTVSDLTASLQEKERAIEA 514

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1614 LKIQADGFKDQLR---STNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQKcdqqniiIQNTKKEVRNLNAELNA 1690
Cdd:pfam15921  515 TNAEITKLRSRVDlklQELQHLKNEGDHLRNVQTECEALKLQMAEKDKVIEILRQQ-------IENMTQLVGQHGRTAGA 587

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1691 SKEEKRRGEQKVQLQQAQVQELnnRLKKVQDELHLKTIEEQMTH---RKMVLFQEESGKFKqSAEEFRKKMEKLMESKVI 1767
Cdd:pfam15921  588 MQVEKAQLEKEINDRRLELQEF--KILKDKKDAKIRELEARVSDlelEKVKLVNAGSERLR-AVKDIKQERDQLLNEVKT 664

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1768 TENDISGIRLDFVSLQQeNSRAQENAKLCETN-----IKELERQLQQYREQMQQGQHMEANHYQKCQKLEDELIAQKREV 1842
Cdd:pfam15921  665 SRNELNSLSEDYEVLKR-NFRNKSEEMETTTNklkmqLKSAQSELEQTRNTLKSMEGSDGHAMKVAMGMQKQITAKRGQI 743


                   ....*..
gi 4502443    1843 ENLKQKM 1849
Cdd:pfam15921  744 DALQSKI 750
PTZ00121 PTZ00121
MAEBL; Provisional
 1201-2077 1.89e-13

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 77.10  E-value: 1.89e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1201 ETIVREKEAAERELERVRQLTIEAEAKRAAVEENllnfRNQLEENTFTRrtledhlKRKDLSLNDLEQQKNKLMEELRRK 1280
Cdd:PTZ00121 1039 DDVLKEKDIIDEDIDGNHEGKAEAKAHVGQDEGL----KPSYKDFDFDA-------KEDNRADEATEEAFGKAEEAKKTE 1107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1281 RDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIElEARRKiteiqytcrENALPVCPITQATSCRAVTGLQQEHDKQK 1360
Cdd:PTZ00121 1108 TGKAEEARKAEEAKKKAEDARKAEEARKAEDARKAE-EARKA---------EDAKRVEIARKAEDARKAEEARKAEDAKK 1177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1361 AEELKQQVDELTAAN-RKAE-----QDMRELTYELNALQLEKTSSEEKARLLKdKLDETNNTLRCLKLELERKDQAEKGY 1434
Cdd:PTZ00121 1178 AEAARKAEEVRKAEElRKAEdarkaEAARKAEEERKAEEARKAEDAKKAEAVK-KAEEAKKDAEEAKKAEEERNNEEIRK 1256

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1435 SQQLRELGRQLNQTTGKAEEAmQEASDLKKIKRNYQLELESLNHEKGKLQ---------REVDRITRAHAVAEKNIQHLN 1505
Cdd:PTZ00121 1257 FEEARMAHFARRQAAIKAEEA-RKADELKKAEEKKKADEAKKAEEKKKADeakkkaeeaKKADEAKKKAEEAKKKADAAK 1335

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1506 SQIHSFRDEKELERLQiCQRKSDHLKEQFEKSHEQLLQNiKAEKENNDKIQRLNEELEKSNEC---AEMLKQKVEELTRQ 1582
Cdd:PTZ00121 1336 KKAEEAKKAAEAAKAE-AEAAADEAEAAEEKAEAAEKKK-EEAKKKADAAKKKAEEKKKADEAkkkAEEDKKKADELKKA 1413

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1583 NNETKlMMQRIQAESENIVLEKQTIQQRCEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQRKIKCLEE----DLAKSQn 1658
Cdd:PTZ00121 1414 AAAKK-KADEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEakkaDEAKKK- 1491

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1659 lVSEFKQKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQLQQAQVQELNNRLKKVQDELHLKTIEEQMTHRKMV 1738
Cdd:PTZ00121 1492 -AEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAK 1570

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1739 LFQEESGKFKQSAEEFRKKMEKLMEskvitenDISGIRLDFVSLQQENSRAQENAKLCETNIKELERQlqqyREQMQQGQ 1818
Cdd:PTZ00121 1571 KAEEDKNMALRKAEEAKKAEEARIE-------EVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEE----KKKVEQLK 1639

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1819 HMEANHYQKCQKLEDELIAQKREVENLKQKMDQQIKEHEHqlvLLQCEIQKKSTAKDCTFKPDFEMTVKECQHSGELSSR 1898
Cdd:PTZ00121 1640 KKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEE---AKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKK 1716

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1899 NTGHLHPTPRSPLLRWTQEPQPLEEkwQHRVVEQIPKEVQFQPPGAPLEKEKSQQCySEYFSQTSTELQITFDETNPITR 1978
Cdd:PTZ00121 1717 KAEELKKAEEENKIKAEEAKKEAEE--DKKKAEEAKKDEEEKKKIAHLKKEEEKKA-EEIRKEKEAVIEEELDEEDEKRR 1793

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1979 LSEIEKIRD--------QALNNSRPPvrYQDNACEMElVKVLTPLEIAKNKQYDMHTEVTTLKQEKNPVpSAEEWMLEGC 2050
Cdd:PTZ00121 1794 MEVDKKIKDifdnfaniIEGGKEGNL--VINDSKEME-DSAIKEVADSKNMQLEEADAFEKHKFNKNNE-NGEDGNKEAD 1869

                         890       900
                  ....*....|....*....|....*..
gi 4502443   2051 RASGGLKKGDFLKKGLEPETFQNFDGD 2077
Cdd:PTZ00121 1870 FNKEKDLKEDDEEEIEEADEIEKIDKD 1896
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1122-1620 3.86e-13

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 75.74  E-value: 3.86e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1122 LLQRQKATVLENSKLTGKISELERMVAELKKQKSRVEEELPKVREAAENELRKQQRNVEDISLQKIRAESEAKQYRRELE 1201
Cdd:COG1196  244 LEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEE 323

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1202 TIVREKEAAERELERVRQLTIEAEAKRAAVEENLLNFRNQLEEntftRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKR 1281
Cdd:COG1196  324 ELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEA----LLEAEAELAEAEEELEELAEELLEALRAAAELA 399

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1282 DNEEELLKLIKQMEKDLA-FQKQVAEKQLKEKQKIELEARRKITEIQYTCRENALpvcpitqatscravtGLQQEHDKQK 1360
Cdd:COG1196  400 AQLEELEEAEEALLERLErLEEELEELEEALAELEEEEEEEEEALEEAAEEEAEL---------------EEEEEALLEL 464

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1361 AEELKQQVDELTAANRKAEQDMRELTYELNALQLEKTSSEEKARLLKDKLDETNNTLRCLKLELERKDQAEKGYSQQLRE 1440
Cdd:COG1196  465 LAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAALEAAL 544

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1441 LGRQLNQTTGKAEEAMQEASDLK-------------KIKRNYQLELESLNHEKGKLQREVDRITRAHA---------VAE 1498
Cdd:COG1196  545 AAALQNIVVEDDEVAAAAIEYLKaakagratflpldKIRARAALAAALARGAIGAAVDLVASDLREADaryyvlgdtLLG 624

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1499 KNIQHLNSQIHSFRDEKELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEELEKSNECAEMLKQKVEE 1578
Cdd:COG1196  625 RTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEE 704

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|..
gi 4502443  1579 LTRQNNETKLMMQRIQAESENIVLEKQTIQQRCEALKIQADG 1620
Cdd:COG1196  705 EERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEE 746
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 1174-1864 3.87e-13

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 75.53  E-value: 3.87e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1174 KQQRNVEDISLQKIRAESEAKQYRRELEtivREKEAAERELERVRQLTIEAEAKRAAVEENLLNFRNQLEENTFTRrtle 1253
Cdd:pfam05483   82 KLYKEAEKIKKWKVSIEAELKQKENKLQ---ENRKIIEAQRKAIQELQFENEKVSLKLEEEIQENKDLIKENNATR---- 154

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1254 dHLkrkdlsLNDLEQQKNKLMEELRRKRDNEEELLKLIKQMEKDLafqkqvaEKQLKEKQKIELEARRKITEIQYTCREN 1333
Cdd:pfam05483  155 -HL------CNLLKETCARSAEKTKKYEYEREETRQVYMDLNNNI-------EKMILAFEELRVQAENARLEMHFKLKED 220

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1334 AlpvcpitqatscRAVTGLQQEHDKQKAEElKQQVDELTAANRKAEQDMRELTYELNALQLEKTSSEEKARLLKDKLDET 1413
Cdd:pfam05483  221 H------------EKIQHLEEEYKKEINDK-EKQVSLLLIQITEKENKMKDLTFLLEESRDKANQLEEKTKLQDENLKEL 287

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1414 N-------NTLRCLKLELERKDQAEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLKKIKRNYQLELES--------LNH 1478
Cdd:pfam05483  288 IekkdhltKELEDIKMSLQRSMSTQKALEEDLQIATKTICQLTEEKEAQMEELNKAKAAHSFVVTEFEAttcsleelLRT 367

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1479 EKGKLQREVDRITRAHAVAEKNIQHLnSQIHSFRDEK--ELERLQICQRKSDHL---KEQFEKSHEQlLQNIKAE----- 1548
Cdd:pfam05483  368 EQQRLEKNEDQLKIITMELQKKSSEL-EEMTKFKNNKevELEELKKILAEDEKLldeKKQFEKIAEE-LKGKEQElifll 445

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1549 KENNDKIQRLNEELEKSNECAEMLKQKVEELTRQNNETKLMMQRIQAESENIVLEKQTIQQRCEALKIqadgfkdQLRST 1628
Cdd:pfam05483  446 QAREKEIHDLEIQLTAIKTSEEHYLKEVEDLKTELEKEKLKNIELTAHCDKLLLENKELTQEASDMTL-------ELKKH 518

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1629 NEHLHKQTKTEQDFQRKIKCLEEDLAKSQN----LVSEFKQKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQL 1704
Cdd:pfam05483  519 QEDIINCKKQEERMLKQIENLEEKEMNLRDelesVREEFIQKGDEVKCKLDKSEENARSIEYEVLKKEKQMKILENKCNN 598

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1705 QQAQVQELNNRLKKVQDELHLKTIEEQMTHRKMVLFQEESGKF-------KQSAEEFRKKMEKLMESKVITENDISG--- 1774
Cdd:pfam05483  599 LKKQIENKNKNIEELHQENKALKKKGSAENKQLNAYEIKVNKLelelasaKQKFEEIIDNYQKEIEDKKISEEKLLEeve 678

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1775 ----IRLDFVSLQQE-NSRAQ----ENAKLCETN-------IKELERQLQQYREQMQQGQHMEANHYQKCQKLEDELIAQ 1838
Cdd:pfam05483  679 kakaIADEAVKLQKEiDKRCQhkiaEMVALMEKHkhqydkiIEERDSELGLYKNKEQEQSSAKAALEIELSNIKAELLSL 758

                          730       740
                   ....*....|....*....|....*.
gi 4502443    1839 KREVENLKQKMDQQIKEHEHQLVLLQ 1864
Cdd:pfam05483  759 KKQLEIEKEEKEKLKMEAKENTAILK 784
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 2480-2517 3.88e-13

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 459901  Cd Length: 39  Bit Score: 65.43  E-value: 3.88e-13
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 4502443    2480 LEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQL 2517
Cdd:pfam00681    2 LEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQKL 39
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1207-1816 4.50e-13

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 75.36  E-value: 4.50e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1207 KEAAERELERVRQ-LTiEAEAKRAAVEENLlnfrNQLE---ENTFTRRTLEDHLKRKDLSL-----NDLEQQKNKLMEEL 1277
Cdd:COG1196  174 KEEAERKLEATEEnLE-RLEDILGELERQL----EPLErqaEKAERYRELKEELKELEAELlllklRELEAELEELEAEL 248

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1278 RRKRDNEEELLKLIKQMEKDLAFQKQV---AEKQLKEKQKIELEARRKITEIQytcrenalpvcpitqatscravtgLQQ 1354
Cdd:COG1196  249 EELEAELEELEAELAELEAELEELRLEleeLELELEEAQAEEYELLAELARLE------------------------QDI 304

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1355 EHDKQKAEELKQQVDELTAANRKAEQDMRELTYELNALQLEKTSSEEKARLLKDKLDETNNTLRCLKLELERKDQAEKGY 1434
Cdd:COG1196  305 ARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEEL 384

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1435 SQQLRELGRQLNQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFRD- 1513
Cdd:COG1196  385 AEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLEl 464

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1514 -EKELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEELEKSNECAEmLKQKVEELTRQNNETKLMMQR 1592
Cdd:COG1196  465 lAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGL-AGAVAVLIGVEAAYEAALEAA 543

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1593 IQAESENIVLEKQTIQQRC-EALKIQADGF-------KDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEF- 1663
Cdd:COG1196  544 LAAALQNIVVEDDEVAAAAiEYLKAAKAGRatflpldKIRARAALAAALARGAIGAAVDLVASDLREADARYYVLGDTLl 623

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1664 -----KQKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQLQQAQVQELNNRLKKVQDELHLKTIEEQMTHRKMV 1738
Cdd:COG1196  624 grtlvAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEE 703

                        570       580       590       600       610       620       630
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4502443  1739 LFQEESGKFKQSAEEFRKKMEKLMESKVITENDISGIRLDFvslQQENSRAQENAKLCETNIKELERQLQQYREQMQQ 1816
Cdd:COG1196  704 EEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEE---EELLEEEALEELPEPPDLEELERELERLEREIEA 778
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 852-1767 6.20e-13

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 75.08  E-value: 6.20e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443     852 LKNTQAAEALVKLYETKLCEEEAVIADKNN-----------IENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEM 920
Cdd:TIGR00606  202 VQEHQMELKYLKQYKEKACEIRDQITSKEAqlessreivksYENELDPLKNRLKEIEHNLSKIMKLDNEIKALKSRKKQM 281

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443     921 FKTYKerdldfdwhkekadQLVERWQNVHVQIDNRLRDLegigkslkyYRDTYHPLDDWIQQVETTQRKIQENQPEnskt 1000
Cdd:TIGR00606  282 EKDNS--------------ELELKMEKVFQGTDEQLNDL---------YHNHQRTVREKERELVDCQRELEKLNKE---- 334

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1001 lATQLNQQKmlvSEIEMKQSKMdECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSP-----------VKRRRMQSSADL 1069
Cdd:TIGR00606  335 -RRLLNQEK---TELLVEQGRL-QLQADRHQEHIRARDSLIQSLATRLELDGFERGPfserqiknfhtLVIERQEDEAKT 409

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1070 IIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEhgaysdllqrQKATVLENSKLTGKISELERMVAE 1149
Cdd:TIGR00606  410 AAQLCADLQSKERLKQEQADEIRDEKKGLGRTIELKKEILEKKQEE----------LKFVIKELQQLEGSSDRILELDQE 479

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1150 LKKQksrvEEELPKVREAAENELRKQQ----RNVEDISLQKIRAESEA-------KQYRRELETIVREKEAAERELERVR 1218
Cdd:TIGR00606  480 LRKA----ERELSKAEKNSLTETLKKEvkslQNEKADLDRKLRKLDQEmeqlnhhTTTRTQMEMLTKDKMDKDEQIRKIK 555

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1219 QLTIEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKLI------K 1292
Cdd:TIGR00606  556 SRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASLEQNKNHINNELESKEEQLSSYEDKLfdvcgsQ 635

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1293 QMEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCRENAlPVCPITQatscravtglqqeHDKQKAEELKQQVDELT 1372
Cdd:TIGR00606  636 DEESDLERLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQ-SCCPVCQ-------------RVFQTEAELQEFISDLQ 701

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1373 AANRKAEQDMRELTYELNALQLEKTSSEEKARLLKDKLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLNQTTGKA 1452
Cdd:TIGR00606  702 SKLRLAPDKLKSTESELKKKEKRRDEMLGLAPGRQSIIDLKEKEIPELRNKLQKVNRDIQRLKNDIEEQETLLGTIMPEE 781

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1453 EEAMQEASDLKKIKRNYQ----------------------LELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHS 1510
Cdd:TIGR00606  782 ESAKVCLTDVTIMERFQMelkdverkiaqqaaklqgsdldRTVQQVNQEKQEKQHELDTVVSKIELNRKLIQDQQEQIQH 861

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1511 FR---DEKELERLQICQRKSDhlKEQFEkshEQLLQNIKAEKENNDKIQRLNEELEKSNECAEMLKQKVEELTRQNNETK 1587
Cdd:TIGR00606  862 LKsktNELKSEKLQIGTNLQR--RQQFE---EQLVELSTEVQSLIREIKDAKEQDSPLETFLEKDQQEKEELISSKETSN 936

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1588 LM----MQRIQAESENIVLEKQTIQQrcealKIQaDGFKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEF 1663
Cdd:TIGR00606  937 KKaqdkVNDIKEKVKNIHGYMKDIEN-----KIQ-DGKDDYLKQKETELNTVNAQLEECEKHQEKINEDMRLMRQDIDTQ 1010

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1664 KQkcdQQNIIIQNTKKEVRNlnaelNASKEEKRRGEQKV-QLQQAQVQELNNRLKKVQDELHLKTIEEQMTHRKMVLFQE 1742
Cdd:TIGR00606 1011 KI---QERWLQDNLTLRKRE-----NELKEVEEELKQHLkEMGQMQVLQMKQEHQKLEENIDLIKRNHVLALGRQKGYEK 1082

                          970       980
                   ....*....|....*....|....*..
gi 4502443    1743 ESGKFKQ--SAEEFRKKMEKLMESKVI 1767
Cdd:TIGR00606 1083 EIKHFKKelREPQFRDAEEKYREMMIV 1109
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 882-1615 8.79e-13

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 74.71  E-value: 8.79e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443     882 IENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDldfdwhkEKADQLVERWQNVHVQIDNRLRDLEG 961
Cdd:TIGR02168  234 LEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELE-------EEIEELQKELYALANEISRLEQQKQI 306

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443     962 IGKSLKYYRDTYHPLDDWIQQVETTQRKIQEN---QPENSKTLATQLNQQKMLVSEIEMKQ----SKMDECQKYAEQYSA 1034
Cdd:TIGR02168  307 LRERLANLERQLEELEAQLEELESKLDELAEElaeLEEKLEELKEELESLEAELEELEAELeeleSRLEELEEQLETLRS 386

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1035 TVKDYELQTMTYRAMV---DSQQKSPVKRRRMQSS------ADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEE 1105
Cdd:TIGR02168  387 KVAQLELQIASLNNEIerlEARLERLEDRRERLQQeieellKKLEEAELKELQAELEELEEELEELQEELERLEEALEEL 466

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1106 EIKRCKETSEHGAYSDLLQRQKATVLENSKLTGKISELERMVAELKKQKSRVEEELPKVRE----------AAENELRKQ 1175
Cdd:TIGR02168  467 REELEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGVKALLKNQSGLSGILGVLSElisvdegyeaAIEAALGGR 546

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1176 QRNVEDISLQKIRAESEA-KQYRRELETI-----VREKEAAERELERVRQL-----------TIEAEAKRA--------A 1230
Cdd:TIGR02168  547 LQAVVVENLNAAKKAIAFlKQNELGRVTFlpldsIKGTEIQGNDREILKNIegflgvakdlvKFDPKLRKAlsyllggvL 626

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1231 VEENLLNFRNQLEENTFTRR--TLEDHL---------KRKDLSLNDLEQQKNklMEELRRKRDNEEELLKLIKQMEKDLA 1299
Cdd:TIGR02168  627 VVDDLDNALELAKKLRPGYRivTLDGDLvrpggvitgGSAKTNSSILERRRE--IEELEEKIEELEEKIAELEKALAELR 704

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1300 FQKQVAEKQLKEKQKIELEARRKI--TEIQYTCRENAlpvcpITQATSCRAVTGLQQEHDKQKAEELKQQVDELTAANRK 1377
Cdd:TIGR02168  705 KELEELEEELEQLRKELEELSRQIsaLRKDLARLEAE-----VEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAE 779

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1378 AEQDMRELTYELNALQLEKTSSEEKarllkdkLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLNQTTGKAEEAmq 1457
Cdd:TIGR02168  780 AEAEIEELEAQIEQLKEELKALREA-------LDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEEL-- 850

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1458 easdlkkikrnyQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFRDEKELERLQIcqrksdhlkeqfeKS 1537
Cdd:TIGR02168  851 ------------SEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRSELEELSEEL-------------RE 905

                          730       740       750       760       770       780       790
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4502443    1538 HEqllqniKAEKENNDKIQRLNEELEKSNECAEMLKQKVEELTRQ-NNETKLMMQRIQAESENIVLEKQTIQQRCEALK 1615
Cdd:TIGR02168  906 LE------SKRSELRRELEELREKLAQLELRLEGLEVRIDNLQERlSEEYSLTLEEAEALENKIEDDEEEARRRLKRLE 978
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1100-1579 2.72e-12

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 72.79  E-value: 2.72e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1100 KRLEEEEIKRCKETSEHGAYSDLLQRQKATVLENSKLTGKISELERMVAELKKQKSRVEEELPKVREAAE--NELRKQQR 1177
Cdd:PRK03918  283 KELKELKEKAEEYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEERIKELEEKEERLEELKKKLKELEKrlEELEERHE 362

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1178 NVEDI--------SLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLTIEAEAKRAAVEENLLNFRNQLEENTFTR 1249
Cdd:PRK03918  363 LYEEAkakkeeleRLKKRLTGLTPEKLEKELEELEKAKEEIEEEISKITARIGELKKEIKELKKAIEELKKAKGKCPVCG 442

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1250 RTLEDH-----LKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKLIKQmEKDLAFQKQVAE--KQLKEK-QKIELEarr 1321
Cdd:PRK03918  443 RELTEEhrkelLEEYTAELKRIEKELKEIEEKERKLRKELRELEKVLKK-ESELIKLKELAEqlKELEEKlKKYNLE--- 518

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1322 kiteiqytcrenalpvcpitqatscravtglQQEHDKQKAEELKQQVDELTAANRKAEQDMRELtyelNALQLEKTSSEE 1401
Cdd:PRK03918  519 -------------------------------ELEKKAEEYEKLKEKLIKLKGEIKSLKKELEKL----EELKKKLAELEK 563

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1402 KARLLKDKLDETNNTLRCLKLELERKDQAEkgysqqLRELgrqlnqttgkaEEAMQEASDLKKIKRnyqlELESLNHEKG 1481
Cdd:PRK03918  564 KLDELEEELAELLKELEELGFESVEELEER------LKEL-----------EPFYNEYLELKDAEK----ELEREEKELK 622

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1482 KLQREVDRITRAHAVAEKNIQHLNSQIHSFR---DEKELERL-QICQRKSDHLK------EQFEKSHEQL---LQNIKAE 1548
Cdd:PRK03918  623 KLEEELDKAFEELAETEKRLEELRKELEELEkkySEEEYEELrEEYLELSRELAglraelEELEKRREEIkktLEKLKEE 702

                         490       500       510
                  ....*....|....*....|....*....|.
gi 4502443   1549 KENNDKIQRLNEELEKSNECAEMLKQKVEEL 1579
Cdd:PRK03918  703 LEEREKAKKELEKLEKALERVEELREKVKKY 733
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 2170-2208 3.13e-12

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 459901  Cd Length: 39  Bit Score: 62.73  E-value: 3.13e-12
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 4502443    2170 FLEAQAATGFIIDPISGQTYSVEDAVLKGVVDPEFRIRL 2208
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQKL 39
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1352-1860 3.73e-12

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 72.28  E-value: 3.73e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1352 LQQEHDKQKAEELKQQVDELTAANRKAEQDMRELTYELNALQLEKTSSEEKARLLKDKLDEtnntlrcLKLELERKdqae 1431
Cdd:COG1196  218 LKEELKELEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEE-------LELELEEA---- 286

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1432 kgySQQLRELGRQLNQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSF 1511
Cdd:COG1196  287 ---QAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEA 363

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1512 ---RDEKELERLQICQRKSDHLKEQFEKSHE------QLLQNIKAEKENNDKIQRLNEELEKSNECAEMLKQKVEELTRQ 1582
Cdd:COG1196  364 eeaLLEAEAELAEAEEELEELAEELLEALRAaaelaaQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEA 443

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1583 NNETKLMMQRIQAESEN---IVLEKQTIQQRCEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQRKIKclEEDLAKSQNL 1659
Cdd:COG1196  444 LEEAAEEEAELEEEEEAlleLLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVK--AALLLAGLRG 521

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1660 VSEFKQKCDQ-----------------QNIIIQNTK--KEVRNLNAELNASKEEKRRGEQKVQLQQAQVQELNNRLKKVQ 1720
Cdd:COG1196  522 LAGAVAVLIGveaayeaaleaalaaalQNIVVEDDEvaAAAIEYLKAAKAGRATFLPLDKIRARAALAAALARGAIGAAV 601

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1721 DELHLKTIEEQMTHRKMVLFQEESGKFKQSAEEFRKKMEKLMESKVITENDISGIRLDFVSLQQENSRAQENAKLCETNI 1800
Cdd:COG1196  602 DLVASDLREADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAEL 681

                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1801 KELERQLQQYREQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQKMDQQIKEHEHQL 1860
Cdd:COG1196  682 EELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEEL 741
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 1514-1846 4.85e-12

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 72.02  E-value: 4.85e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1514 EKELERLQICQRKSDHLKEQFEKSHEQLlQNIKAEKENNDKIQRLNEELEKSnECAEMLKQKvEELTRQNNETKLMMQRI 1593
Cdd:TIGR02169  173 EKALEELEEVEENIERLDLIIDEKRQQL-ERLRREREKAERYQALLKEKREY-EGYELLKEK-EALERQKEAIERQLASL 249

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1594 QAESENIVLEKQTIQQRCEALKiqadgfkDQLRSTNEHLHKQTKTEQ-DFQRKIKCLEEDLAKSQNLVSEFKQKcdqqni 1672
Cdd:TIGR02169  250 EEELEKLTEEISELEKRLEEIE-------QLLEELNKKIKDLGEEEQlRVKEKIGELEAEIASLERSIAEKERE------ 316

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1673 iIQNTKKEVRNLNAELNASKEEKRRGEQKVQLQQAQVQELNNRLKKVQDELHLKT--IEE-----QMTHRKMVLFQEESG 1745
Cdd:TIGR02169  317 -LEDAEERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRaeLEEvdkefAETRDELKDYREKLE 395

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1746 KFKQSAEEFRKKMEKLMESKVITENDISGIRLDFVSLQQENSRAQENAKLCETNIKELERQLQQYREQMQQGQHMEANHY 1825
Cdd:TIGR02169  396 KLKREINELKRELDRLQEELQRLSEELADLNAAIAGIEAKINELEEEKEDKALEIKKQEWKLEQLAADLSKYEQELYDLK 475

                          330       340
                   ....*....|....*....|.
gi 4502443    1826 QKCQKLEDELIAQKREVENLK 1846
Cdd:TIGR02169  476 EEYDRVEKELSKLQRELAEAE 496
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 896-1741 7.40e-12

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 71.64  E-value: 7.40e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443     896 VDEKRQVFHALEDELQKA---KAISDEMfktykeRDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDT 972
Cdd:TIGR02169  193 IDEKRQQLERLRREREKAeryQALLKEK------REYEGYELLKEKEALERQKEAIERQLASLEEELEKLTEEISELEKR 266

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443     973 YHPLDDWIQQVEttqRKIQENQPENSKTLATQLNQqkmLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDS 1052
Cdd:TIGR02169  267 LEEIEQLLEELN---KKIKDLGEEEQLRVKEKIGE---LEAEIASLERSIAEKERELEDAEERLAKLEAEIDKLLAEIEE 340

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1053 QQKS--PVKRRRMQssadlIIQEFMDLRTRYTALVtlmtqyikfagdslKRLEEEEiKRCKETSEhgaysdllqRQKATV 1130
Cdd:TIGR02169  341 LEREieEERKRRDK-----LTEEYAELKEELEDLR--------------AELEEVD-KEFAETRD---------ELKDYR 391

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1131 LENSKLTGKISELERMVAELKKQKSRVEEELPKVREAAEnelrkqqrnvedislqkiRAESEAKQYRRELETIVREKEAA 1210
Cdd:TIGR02169  392 EKLEKLKREINELKRELDRLQEELQRLSEELADLNAAIA------------------GIEAKINELEEEKEDKALEIKKQ 453

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1211 ERELERVRqltieaeAKRAAVEENLLNFRNQLEEntftrrtLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLK- 1289
Cdd:TIGR02169  454 EWKLEQLA-------ADLSKYEQELYDLKEEYDR-------VEKELSKLQRELAEAEAQARASEERVRGGRAVEEVLKAs 519

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1290 ----------LIKQMEKDLA---------FQKQVAEKQLKEKQKIELEARRKITEIQY----TCRENALPVCPITQATSC 1346
Cdd:TIGR02169  520 iqgvhgtvaqLGSVGERYATaievaagnrLNNVVVEDDAVAKEAIELLKRRKAGRATFlplnKMRDERRDLSILSEDGVI 599

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1347 RAVTGLQqEHDKQKAEELKQQ------VDELTAANRKAEQdMRELTYE----------------LNALQLEKTSSEEKAR 1404
Cdd:TIGR02169  600 GFAVDLV-EFDPKYEPAFKYVfgdtlvVEDIEAARRLMGK-YRMVTLEgelfeksgamtggsraPRGGILFSRSEPAELQ 677

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1405 LLKDKLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQ 1484
Cdd:TIGR02169  678 RLRERLEGLKRELSSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEIENVK 757

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1485 REVDRITRAHAVAEKNIQHLNSQIHSFRDEKELERLQICQRKSDHLKEQFEK------SHEQLLQNIKAEKEN-NDKIQR 1557
Cdd:TIGR02169  758 SELKELEARIEELEEDLHKLEEALNDLEARLSHSRIPEIQAELSKLEEEVSRiearlrEIEQKLNRLTLEKEYlEKEIQE 837

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1558 LNEELEKSNECAEMLKQKVEELTRQNNETKLMMQRIQAESENIVLEKQTIQQRCEALKIQADGFKDQLRSTNEHLHKQTK 1637
Cdd:TIGR02169  838 LQEQRIDLKEQIKSIEKEIENLNGKKEELEEELEELEAALRDLESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRK 917

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1638 TEQDFQRKIKCLEEDLAKSQNLVSEFKQKcDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQK---VQLQQAQVQELNN 1714
Cdd:TIGR02169  918 RLSELKAKLEALEEELSEIEDPKGEDEEI-PEEELSLEDVQAELQRVEEEIRALEPVNMLAIQEyeeVLKRLDELKEKRA 996

                          890       900
                   ....*....|....*....|....*..
gi 4502443    1715 RLKKVQDELhLKTIEEQMTHRKMVLFQ 1741
Cdd:TIGR02169  997 KLEEERKAI-LERIEEYEKKKREVFME 1022
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1099-1600 1.09e-11

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 70.86  E-value: 1.09e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1099 LKRLEEEEIKRCKETSEHGAYSDLLQRQKATVLENSKLTGKISELERMVAELKKQKSRVEEELPKVREAAEnELRKQQRN 1178
Cdd:PRK03918  206 LREINEISSELPELREELEKLEKEVKELEELKEEIEELEKELESLEGSKRKLEEKIRELEERIEELKKEIE-ELEEKVKE 284

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1179 VEDI---SLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLTIEAEAKRAAVEEnllnFRNQLEEntfTRRTLEDh 1255
Cdd:PRK03918  285 LKELkekAEEYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEERIKELEEKEERLEE----LKKKLKE---LEKRLEE- 356

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1256 LKRKDLSLNDLEQQKNKlMEELRRKRDNE--EELLKLIKQMEKDlafQKQVAEKQLKEKQKI-ELEARRKITEIQYTCRE 1332
Cdd:PRK03918  357 LEERHELYEEAKAKKEE-LERLKKRLTGLtpEKLEKELEELEKA---KEEIEEEISKITARIgELKKEIKELKKAIEELK 432

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1333 NALPVCPItqatsCRAVtgLQQEHDKQKAEELKQQVDELTAANRKAEQDMRELTYELNALQ--LEKTSSEEKARLLKDKL 1410
Cdd:PRK03918  433 KAKGKCPV-----CGRE--LTEEHRKELLEEYTAELKRIEKELKEIEEKERKLRKELRELEkvLKKESELIKLKELAEQL 505

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1411 DETNNTLRCLKLE-LERKDQAEKGYSQQLRELG---RQLNQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKL--- 1483
Cdd:PRK03918  506 KELEEKLKKYNLEeLEKKAEEYEKLKEKLIKLKgeiKSLKKELEKLEELKKKLAELEKKLDELEEELAELLKELEELgfe 585

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1484 -QREVD-RITRAHAVAEKNIQHLNSQIHSFRDEKELERLQicqrksDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEE 1561
Cdd:PRK03918  586 sVEELEeRLKELEPFYNEYLELKDAEKELEREEKELKKLE------EELDKAFEELAETEKRLEELRKELEELEKKYSEE 659

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*...
gi 4502443   1562 ---------LEKSNECAEmLKQKVEELTRQNNETKLMMQRIQAESENI 1600
Cdd:PRK03918  660 eyeelreeyLELSRELAG-LRAELEELEKRREEIKKTLEKLKEELEER 706
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 1155-1899 1.19e-11

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 70.59  E-value: 1.19e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1155 SRVEEELpkvrEAAENELRKQQRnvedislQKIRAESEAKQYRRELETIVREKEAAERELERVRQLTIEAE-------AK 1227
Cdd:pfam01576    1 TRQEEEM----QAKEEELQKVKE-------RQQKAESELKELEKKHQQLCEEKNALQEQLQAETELCAEAEemrarlaAR 69

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1228 RAAVEENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKN---------------------KLMEELRRKRDNEEE 1286
Cdd:pfam01576   70 KQELEEILHELESRLEEEEERSQQLQNEKKKMQQHIQDLEEQLDeeeaarqklqlekvtteakikKLEEDILLLEDQNSK 149

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1287 LLKLIKQMEKDLA-FQKQVAEKQLKEK--QKIELEARRKITEIQYTCRENALPVCPITQATscRAVTGLQQEHDKQKAeE 1363
Cdd:pfam01576  150 LSKERKLLEERISeFTSNLAEEEEKAKslSKLKNKHEAMISDLEERLKKEEKGRQELEKAK--RKLEGESTDLQEQIA-E 226

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1364 LKQQVDELTAANRKAEQDMRELTYELNALQLEKTSSEEKARLLKDKLDEtnntlrcLKLELERKDQAEKGYSQQLRELGR 1443
Cdd:pfam01576  227 LQAQIAELRAQLAKKEEELQAALARLEEETAQKNNALKKIRELEAQISE-------LQEDLESERAARNKAEKQRRDLGE 299

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1444 QLNQTTGKAEEAMQEAsdlkkikrNYQLELES-LNHEKGKLQREVDRITRAH--AVAEKNIQHlNSQIHSFRDEKE-LER 1519
Cdd:pfam01576  300 ELEALKTELEDTLDTT--------AAQQELRSkREQEVTELKKALEEETRSHeaQLQEMRQKH-TQALEELTEQLEqAKR 370

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1520 LQICQRKSDHL--KEQFEKSHE-QLLQNIKAEKENNDKiqRLNEELEKsnecaemLKQKVEELTRQNNETKLMMQRIQAE 1596
Cdd:pfam01576  371 NKANLEKAKQAleSENAELQAElRTLQQAKQDSEHKRK--KLEGQLQE-------LQARLSESERQRAELAEKLSKLQSE 441

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1597 SENIVLEKQTIQQRCEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSE---FKQKCDQQ--- 1670
Cdd:pfam01576  442 LESVSSLLNEAEGKNIKLSKDVSSLESQLQDTQELLQEETRQKLNLSTRLRQLEDERNSLQEQLEEeeeAKRNVERQlst 521

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1671 -NIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQLQQAQVQE-------LNNRLKKVQDELHLKTIEEQMTHRKMVLFQE 1742
Cdd:pfam01576  522 lQAQLSDMKKKLEEDAGTLEALEEGKKRLQRELEALTQQLEEkaaaydkLEKTKNRLQQELDDLLVDLDHQRQLVSNLEK 601

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1743 ESGKFKQSAEEfrkkmEKLMESKVITENDisgirldfvslqqensRAQENAKLCETNIKELERQLQQYREQMQqgqhmEA 1822
Cdd:pfam01576  602 KQKKFDQMLAE-----EKAISARYAEERD----------------RAEAEAREKETRALSLARALEEALEAKE-----EL 655

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1823 NHYQKCQKLE-DELIAQK-------REVENLKQKMDQQIKEHEHQLVLLQCEIQkksTAKDCTFKPDFEMTVKECQHSGE 1894
Cdd:pfam01576  656 ERTNKQLRAEmEDLVSSKddvgknvHELERSKRALEQQVEEMKTQLEELEDELQ---ATEDAKLRLEVNMQALKAQFERD 732


                   ....*
gi 4502443    1895 LSSRN 1899
Cdd:pfam01576  733 LQARD 737
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 1191-1879 1.28e-11

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 70.77  E-value: 1.28e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1191 SEAKQYRRELETivrEKEAAERELERVRQLTIEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDlEQQK 1270
Cdd:TIGR00618  183 LMEFAKKKSLHG---KAELLTLRSQLLTLCTPCMPDTYHERKQVLEKELKHLREALQQTQQSHAYLTQKREAQEE-QLKK 258

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1271 NKLMEELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQ--KIELEARRKITEIQ--YTCRENALPVCPITQATSC 1346
Cdd:TIGR00618  259 QQLLKQLRARIEELRAQEAVLEETQERINRARKAAPLAAHIKAvtQIEQQAQRIHTELQskMRSRAKLLMKRAAHVKQQS 338

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1347 RAVTGLQQEHDKQKAEELKQQVDELTAANRKAEQDMRELTYELNALQLEKTSSEEKARLLKDKLD-ETNNTLRCLKLELE 1425
Cdd:TIGR00618  339 SIEEQRRLLQTLHSQEIHIRDAHEVATSIREISCQQHTLTQHIHTLQQQKTTLTQKLQSLCKELDiLQREQATIDTRTSA 418

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1426 RKD------QAEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREvdriTRAHAVAEK 1499
Cdd:TIGR00618  419 FRDlqgqlaHAKKQQELQQRYAELCAAAITCTAQCEKLEKIHLQESAQSLKEREQQLQTKEQIHLQE----TRKKAVVLA 494

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1500 NIQHLNSQIHSFRD---EKELERLQICQRKSDHLK----EQFEKSHEQLLQNIKAE-KENNDKIQRLNEELEKSNECAEM 1571
Cdd:TIGR00618  495 RLLELQEEPCPLCGsciHPNPARQDIDNPGPLTRRmqrgEQTYAQLETSEEDVYHQlTSERKQRASLKEQMQEIQQSFSI 574

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1572 LKQKVEELTRQNNETKLMMQRIQAESEniVLEKQTIQQRCEAlkiqadgfKDQLRSTNEHLHKQTK--TEQDFQRKIKCL 1649
Cdd:TIGR00618  575 LTQCDNRSKEDIPNLQNITVRLQDLTE--KLSEAEDMLACEQ--------HALLRKLQPEQDLQDVrlHLQQCSQELALK 644

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1650 EEDLAKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQLQQAQ--VQELNNRLKKVQDELHlkT 1727
Cdd:TIGR00618  645 LTALHALQLTLTQERVREHALSIRVLPKELLASRQLALQKMQSEKEQLTYWKEMLAQCQtlLRELETHIEEYDREFN--E 722

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1728 IEEQMTHRKMVLFQEESGKFKQSAEEFRKKMEKLMESKVITENDISGIRLDFVSLQQENSRAQENAKLCETnIKELERQL 1807
Cdd:TIGR00618  723 IENASSSLGSDLAAREDALNQSLKELMHQARTVLKARTEAHFNNNEEVTAALQTGAELSHLAAEIQFFNRL-REEDTHLL 801

                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4502443    1808 QQYREQMQQgqhmEANHYQKCQKLEDELIAQKRE-VENLKQKMDQQIKEHEHQLVLLQCEIQKKSTAKDCTFK 1879
Cdd:TIGR00618  802 KTLEAEIGQ----EIPSDEDILNLQCETLVQEEEqFLSRLEEKSATLGEITHQLLKYEECSKQLAQLTQEQAK 870
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1258-1854 2.99e-11

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 69.32  E-value: 2.99e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1258 RKDLSLNDLEQQKNKLME---ELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEiqytcrena 1334
Cdd:PRK03918  152 RQILGLDDYENAYKNLGEvikEIKRRIERLEKFIKRTENIEELIKEKEKELEEVLREINEISSELPELREE--------- 222

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1335 lpvcpitqatscraVTGLQQEhdKQKAEELKQQVDELTAANRKAEQDMRELTYELNALQLEKTSSEEKARLLKDKLDETN 1414
Cdd:PRK03918  223 --------------LEKLEKE--VKELEELKEEIEELEKELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKVKELK 286

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1415 NtLRCLKLELERKDQAEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLKKIKRnyqlELESLNHEKGKLQREVDRITRAH 1494
Cdd:PRK03918  287 E-LKEKAEEYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEERIKELEEKEE----RLEELKKKLKELEKRLEELEERH 361

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1495 AVAEKNIQHLNsqihsfrdekELERLQicQRKSDHLKEQFEKSHEQLLqniKAEKENNDKIQRLNEELEKSNECAEMLKQ 1574
Cdd:PRK03918  362 ELYEEAKAKKE----------ELERLK--KRLTGLTPEKLEKELEELE---KAKEEIEEEISKITARIGELKKEIKELKK 426

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1575 KVEELTRQNNETKLMMQRIQAESENIVLEKQTIQ-QRCEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDL 1653
Cdd:PRK03918  427 AIEELKKAKGKCPVCGRELTEEHRKELLEEYTAElKRIEKELKEIEEKERKLRKELRELEKVLKKESELIKLKELAEQLK 506

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1654 AKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEqkvqlqqaqvqELNNRLKKVQDELH-----LKTI 1728
Cdd:PRK03918  507 ELEEKLKKYNLEELEKKAEEYEKLKEKLIKLKGEIKSLKKELEKLE-----------ELKKKLAELEKKLDeleeeLAEL 575

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1729 EEQMTHRKMVLFQEESGKFKqSAEEFRKKMEKLMESkvitENDISGIRLDFVSLQQENSRAQENAKLCETNIKELERQLQ 1808
Cdd:PRK03918  576 LKELEELGFESVEELEERLK-ELEPFYNEYLELKDA----EKELEREEKELKKLEEELDKAFEELAETEKRLEELRKELE 650

                         570       580       590       600
                  ....*....|....*....|....*....|....*....|....*.
gi 4502443   1809 QYREQMQQGQHMEAnhYQKCQKLEDELIAQKREVENLKQKMDQQIK 1854
Cdd:PRK03918  651 ELEKKYSEEEYEEL--REEYLELSRELAGLRAELEELEKRREEIKK 694
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1060-1564 3.21e-11

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 69.17  E-value: 3.21e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1060 RRRMQSSADLIIQEFMDLRTRYTALVTLMTQYikfagDSLKRLEE--EEIKRCKETSEHGAYSDLLQRQKATVLENSKLT 1137
Cdd:COG4913  220 EPDTFEAADALVEHFDDLERAHEALEDAREQI-----ELLEPIRElaERYAAARERLAELEYLRAALRLWFAQRRLELLE 294

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1138 GKISELERMVAELKKQKSRVEEELPKVREAAEnELRKQQRNVEDISLQKIRAESEAKQyrRELETIVREKEAAErelERV 1217
Cdd:COG4913  295 AELEELRAELARLEAELERLEARLDALREELD-ELEAQIRGNGGDRLEQLEREIERLE--RELEERERRRARLE---ALL 368

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1218 RQLTIEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEE---LRRKRDN-EEELLKLIKQ 1293
Cdd:COG4913  369 AALGLPLPASAEEFAALRAEAAALLEALEEELEALEEALAEAEAALRDLRRELRELEAEiasLERRKSNiPARLLALRDA 448

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1294 MEKDLAFQK----------QVAEKQLKEKQKIEL-----------------EARRKI------TEIQY------------ 1328
Cdd:COG4913  449 LAEALGLDEaelpfvgeliEVRPEEERWRGAIERvlggfaltllvppehyaAALRWVnrlhlrGRLVYervrtglpdper 528

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1329 -TCRENALP------VCPITQ-----------ATSCRAVTGLQQ------------------EHDKQ------------- 1359
Cdd:COG4913  529 pRLDPDSLAgkldfkPHPFRAwleaelgrrfdYVCVDSPEELRRhpraitragqvkgngtrhEKDDRrrirsryvlgfdn 608

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1360 --KAEELKQQVDELTAANRKAEQDMRELTYELNALQLEKTSSEEKARLLKDKLD--ETNNTLRCLKLELERKDQAekgyS 1435
Cdd:COG4913  609 raKLAALEAELAELEEELAEAEERLEALEAELDALQERREALQRLAEYSWDEIDvaSAEREIAELEAELERLDAS----S 684

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1436 QQLRELGRQLNQttgkAEEAMQEASDlkkikrnyqlELESLNHEKGKLQREVDRitrahavAEKNIQHLNSQIHSFRDEK 1515
Cdd:COG4913  685 DDLAALEEQLEE----LEAELEELEE----------ELDELKGEIGRLEKELEQ-------AEEELDELQDRLEAAEDLA 743

                        570       580       590       600       610
                 ....*....|....*....|....*....|....*....|....*....|
gi 4502443  1516 ELERLQICQRKSDHLKEqfEKSHEQLLQNIKAE-KENNDKIQRLNEELEK 1564
Cdd:COG4913  744 RLELRALLEERFAAALG--DAVERELRENLEERiDALRARLNRAEEELER 791
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 1132-1623 4.15e-11

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 68.89  E-value: 4.15e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1132 ENSKLTGKISELERMVAELKKQKSRVEEELPKVreaaENELRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAE 1211
Cdd:TIGR04523  212 KNKSLESQISELKKQNNQLKDNIEKKQQEINEK----TTEISNTQTQLNQLKDEQNKIKKQLSEKQKELEQNNKKIKELE 287

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1212 RELErvrQLTIEAEAKRAAVEENLLN-FRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKL 1290
Cdd:TIGR04523  288 KQLN---QLKSEISDLNNQKEQDWNKeLKSELKNQEKKLEEIQNQISQNNKIISQLNEQISQLKKELTNSESENSEKQRE 364

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1291 IKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQatscravtgLQQEHdkqkaEELKQQVDE 1370
Cdd:TIGR04523  365 LEEKQNEIEKLKKENQSYKQEIKNLESQINDLESKIQNQEKLNQQKDEQIKK---------LQQEK-----ELLEKEIER 430

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1371 LTAANRKAEQDMRELTYELNALQLEKTSSEEKARLLKDKLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLNQTTG 1450
Cdd:TIGR04523  431 LKETIIKNNSEIKDLTNQDSVKELIIKNLDNTRESLETQLKVLSRSINKIKQNLEQKQKELKSKEKELKKLNEEKKELEE 510

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1451 KAEEAMQEASDLKKikrnyqlELESLNHEKGKLqrevdritrahavaEKNIQHLNSQIHSFRDEKELERLQIcqrKSDHL 1530
Cdd:TIGR04523  511 KVKDLTKKISSLKE-------KIEKLESEKKEK--------------ESKISDLEDELNKDDFELKKENLEK---EIDEK 566

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1531 KEQFEKSHEQLLQNIKAEKENNDKIQRLNEELEKSNECAEMLKQKVEELTRQNNETKLMMQRIQAESENIVLEKQTIQQR 1610
Cdd:TIGR04523  567 NKEIEELKQTQKSLKKKQEEKQELIDQKEKEKKDLIKEIEEKEKKISSLEKELEKAKKENEKLSSIIKNIKSKKNKLKQE 646

                          490
                   ....*....|...
gi 4502443    1611 CEALKIQADGFKD 1623
Cdd:TIGR04523  647 VKQIKETIKEIRN 659
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1099-1538 1.48e-10

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 66.71  E-value: 1.48e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1099 LKRLEEEEIKRCKETSEHGAYSDLLQRQKATVLENSKLTGKISELERMVAELKKQKSRveEELPKVREAAENELRKQQRN 1178
Cdd:COG4717   70 LKELKELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLLQL--LPLYQELEALEAELAELPER 147

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1179 VEdislqkiraesEAKQYRRELETIVREKEAAERELERVR-QLTIEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLK 1257
Cdd:COG4717  148 LE-----------ELEERLEELRELEEELEELEAELAELQeELEELLEQLSLATEEELQDLAEELEELQQRLAELEEELE 216

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1258 RKDLSLNDLEQQKNKLMEELRRKRDNEE----------------------ELLKLIKQMEKDLAFQKQVAEKQLKEKQKI 1315
Cdd:COG4717  217 EAQEELEELEEELEQLENELEAAALEERlkearlllliaaallallglggSLLSLILTIAGVLFLVLGLLALLFLLLARE 296

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1316 ELEARRKITEIQYTCRENALpvcpiTQATSCRAVT--GLQQEHDKQKAEELKQQVDELTAANRKAEQDMRELtyELNALQ 1393
Cdd:COG4717  297 KASLGKEAEELQALPALEEL-----EEEELEELLAalGLPPDLSPEELLELLDRIEELQELLREAEELEEEL--QLEELE 369

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1394 lektssEEKARLLKDKLDETNNTLRCLKLELERKDQAEkgysQQLRELGRQLNQTTGKAEEAM---------QEASDLKK 1464
Cdd:COG4717  370 ------QEIAALLAEAGVEDEEELRAALEQAEEYQELK----EELEELEEQLEELLGELEELLealdeeeleEELEELEE 439

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4502443  1465 IKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKN--IQHLNSQIHsfRDEKELERLQICQRKSDHLKEQFEKSH 1538
Cdd:COG4717  440 ELEELEEELEELREELAELEAELEQLEEDGELAELLqeLEELKAELR--ELAEEWAALKLALELLEEAREEYREER 513
SPEC smart00150
Spectrin repeats;
376-476 2.35e-10

Spectrin repeats;


Pssm-ID: 197544 [Multi-domain]  Cd Length: 101  Bit Score: 59.65  E-value: 2.35e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443      376 HNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRA 455
Cdd:smart00150    1 QQFLRDADELEAWLEEKEQLLASEDLGKDLESVEALLKKHEAFEAELEAHEERVEALNELGEQLIEEGHPDAEEIEERLE 80

                            90       100
                    ....*....|....*....|.
gi 4502443      456 AMQTQWSWILQLCQCVEQHIK 476
Cdd:smart00150   81 ELNERWEELKELAEERRQKLE 101
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 1132-1854 3.22e-10

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 65.97  E-value: 3.22e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1132 ENSKLTGKISELERMVAELKKQKSRVEEELPKVREAAENElrKQQRNVediSLQKIR-AESEAKQYRRELEtivREKEAA 1210
Cdd:pfam01576  216 ESTDLQEQIAELQAQIAELRAQLAKKEEELQAALARLEEE--TAQKNN---ALKKIReLEAQISELQEDLE---SERAAR 287

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1211 ERELERVRQLTIEAEAKRAAVEENLLNFRNQLE-------ENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELrrkrdn 1283
Cdd:pfam01576  288 NKAEKQRRDLGEELEALKTELEDTLDTTAAQQElrskreqEVTELKKALEEETRSHEAQLQEMRQKHTQALEEL------ 361

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1284 eEELLKLIKQMEKDLAFQKQVAEKQLKEKQ---------KIELEARRKITEIQytcrenalpvcpiTQATSCRAVTGLQQ 1354
Cdd:pfam01576  362 -TEQLEQAKRNKANLEKAKQALESENAELQaelrtlqqaKQDSEHKRKKLEGQ-------------LQELQARLSESERQ 427

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1355 EHDKQ-KAEELKQQVDELTAANRKAEQDMRELTYELNAL--QLEKTSS----EEKARL-LKDKLDETNNTLRCLKLELER 1426
Cdd:pfam01576  428 RAELAeKLSKLQSELESVSSLLNEAEGKNIKLSKDVSSLesQLQDTQEllqeETRQKLnLSTRLRQLEDERNSLQEQLEE 507

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1427 KDQAEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNS 1506
Cdd:pfam01576  508 EEEAKRNVERQLSTLQAQLSDMKKKLEEDAGTLEALEEGKKRLQRELEALTQQLEEKAAAYDKLEKTKNRLQQELDDLLV 587

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1507 QIHSFRdeKELERLQICQRKSDH-LKEQFEKSHEQLLQNIKAEKENNDKIQRLneeLEKSNECAEMLKQKvEELTRQNNE 1585
Cdd:pfam01576  588 DLDHQR--QLVSNLEKKQKKFDQmLAEEKAISARYAEERDRAEAEAREKETRA---LSLARALEEALEAK-EELERTNKQ 661

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1586 TKLMMQRIQAESENI-----VLE--KQTIQQRCEALKIQADGFKDQLRSTNEHLHK--------QTKTEQDFQRKIKCLE 1650
Cdd:pfam01576  662 LRAEMEDLVSSKDDVgknvhELErsKRALEQQVEEMKTQLEELEDELQATEDAKLRlevnmqalKAQFERDLQARDEQGE 741

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1651 EDLAKSQNLVSEFKQKCD----QQNIIIQNTKK---EVRNLNAELNASKEEKRRGEQKVQLQQAQVQELNNRLKKV---- 1719
Cdd:pfam01576  742 EKRRQLVKQVRELEAELEderkQRAQAVAAKKKlelDLKELEAQIDAANKGREEAVKQLKKLQAQMKDLQRELEEArasr 821

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1720 --------QDELHLKTIEEQMTHrkmvlFQEE---SGKFKQSAEEFRKKMEKLMES----KVITENDISGIRLDFVSLQQ 1784
Cdd:pfam01576  822 deilaqskESEKKLKNLEAELLQ-----LQEDlaaSERARRQAQQERDELADEIASgasgKSALQDEKRRLEARIAQLEE 896

                          730       740       750       760       770       780       790
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1785 ENSRAQENAKLcetnIKELERQLQQYREQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQKMDQQIK 1854
Cdd:pfam01576  897 ELEEEQSNTEL----LNDRLRKSTLQVEQLTTELAAERSTSQKSESARQQLERQNKELKAKLQEMEGTVK 962
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 868-1602 3.24e-10

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 66.24  E-value: 3.24e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443     868 KLCEEEAVIADKNNIENLISTLK----QWRSEVDEKRQVFHALEDELQ----KAKAISDEMFKTYKERDLDF-------- 931
Cdd:TIGR02169  228 LLKEKEALERQKEAIERQLASLEeeleKLTEEISELEKRLEEIEQLLEelnkKIKDLGEEEQLRVKEKIGELeaeiasle 307

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443     932 ---DWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQ 1008
Cdd:TIGR02169  308 rsiAEKERELEDAEERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAETRDEL 387

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1009 KMLVSEIEMKQSKMDECQKyaeqysatvkdyelqtmtyramvdsqqkspvKRRRMQSSADLIIQEFMDLRTRYTALVTLM 1088
Cdd:TIGR02169  388 KDYREKLEKLKREINELKR-------------------------------ELDRLQEELQRLSEELADLNAAIAGIEAKI 436

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1089 TQYIKFAGDSLKRLEEEEIKRCKETSEHGAYSDLLQRQKATVlenSKLTGKISELERMVAELKKQKSRVEE--------- 1159
Cdd:TIGR02169  437 NELEEEKEDKALEIKKQEWKLEQLAADLSKYEQELYDLKEEY---DRVEKELSKLQRELAEAEAQARASEErvrggrave 513

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1160 ---------------ELPKVRE--------AAENelRKQQRNVED---------------------ISLQKIRAESEAKQ 1195
Cdd:TIGR02169  514 evlkasiqgvhgtvaQLGSVGEryataievAAGN--RLNNVVVEDdavakeaiellkrrkagratfLPLNKMRDERRDLS 591

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1196 YRRELETI--------------------------VREKEAAERELERVRQLTIEAE--AKRAAVEEnllNFRNQLEENTF 1247
Cdd:TIGR02169  592 ILSEDGVIgfavdlvefdpkyepafkyvfgdtlvVEDIEAARRLMGKYRMVTLEGElfEKSGAMTG---GSRAPRGGILF 668

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1248 TRRtLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKLIKQMEKDL----AFQKQVAEKQLKEKQKIElEARRKI 1323
Cdd:TIGR02169  669 SRS-EPAELQRLRERLEGLKRELSSLQSELRRIENRLDELSQELSDASRKIgeieKEIEQLEQEEEKLKERLE-ELEEDL 746

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1324 TEIQYTcRENAlpvcpITQATSCRAVTGLQQEhdkqKAEELKQQVDELTAanRKAEQDMRELTYELNAlqLEKTSSEEKA 1403
Cdd:TIGR02169  747 SSLEQE-IENV-----KSELKELEARIEELEE----DLHKLEEALNDLEA--RLSHSRIPEIQAELSK--LEEEVSRIEA 812

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1404 RllkdkLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKL 1483
Cdd:TIGR02169  813 R-----LREIEQKLNRLTLEKEYLEKEIQELQEQRIDLKEQIKSIEKEIENLNGKKEELEEELEELEAALRDLESRLGDL 887

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1484 QREVDRITRAHAVAEKNIQHLNSQIHSFRD--EKELERLQICQRKSDHL-----KEQFEKSHEQLLQNIKAEKEnndKIQ 1556
Cdd:TIGR02169  888 KKERDELEAQLRELERKIEELEAQIEKKRKrlSELKAKLEALEEELSEIedpkgEDEEIPEEELSLEDVQAELQ---RVE 964

                          810       820       830       840
                   ....*....|....*....|....*....|....*....|....*.
gi 4502443    1557 RLNEELEKSNECAEmlkQKVEELTRQNNETKLMMQRIQAESENIVL 1602
Cdd:TIGR02169  965 EEIRALEPVNMLAI---QEYEEVLKRLDELKEKRAKLEEERKAILE 1007
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 1103-1779 4.29e-10

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 65.76  E-value: 4.29e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1103 EEEEIKRCKETSEHGAYSDLLQRQKATVLENSKLTGKISELERMVAELKKQKSRVEEELPKVREAAENELRKQQRNVE-- 1180
Cdd:pfam02463  293 KEEEELKSELLKLERRKVDDEEKLKESEKEKKKAEKELKKEKEEIEELEKELKELEIKREAEEEEEEELEKLQEKLEQle 372

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1181 ---DISLQKIRAESEAKQYRRELETIVREKEAAER----ELERVRQLTIEAEAKRAAVEENLLNFRNQLEENTFTRRTLE 1253
Cdd:pfam02463  373 eelLAKKKLESERLSSAAKLKEEELELKSEEEKEAqlllELARQLEDLLKEEKKEELEILEEEEESIELKQGKLTEEKEE 452

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1254 DHLKRKDLSLNDLEQQKNKLMEELRRKRDNE---EELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTC 1330
Cdd:pfam02463  453 LEKQELKLLKDELELKKSEDLLKETQLVKLQeqlELLLSRQKLEERSQKESKARSGLKVLLALIKDGVGGRIISAHGRLG 532

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1331 R-ENALPVCPITQATSCRAVTGLQQEHDKQKAEELKQQVDELTAANRKAEQDMRELTYELNALQLEKTSSEEKARLLKDK 1409
Cdd:pfam02463  533 DlGVAVENYKVAISTAVIVEVSATADEVEERQKLVRALTELPLGARKLRLLIPKLKLPLKSIAVLEIDPILNLAQLDKAT 612

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1410 LDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLKKI-KRNYQLELESLNHEKGKLQREVD 1488
Cdd:pfam02463  613 LEADEDDKRAKVVEGILKDTELTKLKESAKAKESGLRKGVSLEEGLAEKSEVKASLsELTKELLEIQELQEKAESELAKE 692

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1489 RITRAHAVAEKNIQHLNSQIHSFRDEKELERLQICQRKSDHLKEQFEKSHEQLLQNI-KAEKENNDKIQRLNEELEKSNE 1567
Cdd:pfam02463  693 EILRRQLEIKKKEQREKEELKKLKLEAEELLADRVQEAQDKINEELKLLKQKIDEEEeEEEKSRLKKEEKEEEKSELSLK 772

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1568 CAEMLKQKVEELTRQNNETKLMMQRIQAESENIVLEKQTIQ-QRCEALKIQADGFKDQLRSTNEHLHKQTKTEQ-----D 1641
Cdd:pfam02463  773 EKELAEEREKTEKLKVEEEKEEKLKAQEEELRALEEELKEEaELLEEEQLLIEQEEKIKEEELEELALELKEEQkleklA 852

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1642 FQRKIKCLEEDLAKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRG------EQKVQLQQAQVQELNNR 1715
Cdd:pfam02463  853 EEELERLEEEITKEELLQELLLKEEELEEQKLKDELESKEEKEKEEKKELEEESQKLnlleekENEIEERIKEEAEILLK 932

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1716 LKKVQDELHL---KTIEEQMTHRKMVL---------FQEESGKFKQSAEEFRKKMEK----LMESKVITENDISGIRLDF 1779
Cdd:pfam02463  933 YEEEPEELLLeeaDEKEKEENNKEEEEernkrlllaKEELGKVNLMAIEEFEEKEERynkdELEKERLEEEKKKLIRAII 1012
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1223-1445 4.65e-10

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 64.40  E-value: 4.65e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1223 EAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKLIKQMEKDLAFQK 1302
Cdd:COG4942   24 EAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQK 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1303 QVAEKQLKEKQKIELEARRKIteiqytcrenALPVCPITQATSCRAVTGLQQEHDKQKAEELKQQVDELTAANRKAEQDM 1382
Cdd:COG4942  104 EELAELLRALYRLGRQPPLAL----------LLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAER 173

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4502443  1383 RELTYELNALQLEKTSSEEKARLLKDKLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQL 1445
Cdd:COG4942  174 AELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEA 236
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1135-1583 5.67e-10

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 64.79  E-value: 5.67e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1135 KLTGKISELERMVAELKKQKSRVEEELPKVREAAENELRKQQRNVEDISLQKIRAESEAKQYRRELE--TIVREKEAAER 1212
Cdd:COG4717   60 KPQGRKPELNLKELKELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLLQllPLYQELEALEA 139

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1213 EL----ERVRQLT------IEAEAKRAAVEENLLNFRNQLEE-NTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKR 1281
Cdd:COG4717  140 ELaelpERLEELEerleelRELEEELEELEAELAELQEELEElLEQLSLATEEELQDLAEELEELQQRLAELEEELEEAQ 219

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1282 DNEEELLKLIKQMEKDLAFQKQvaEKQLKEkQKIELEARRKITEIQYTCRENALPVCPITQATSCRA-VTGLQQEHDKQK 1360
Cdd:COG4717  220 EELEELEEELEQLENELEAAAL--EERLKE-ARLLLLIAAALLALLGLGGSLLSLILTIAGVLFLVLgLLALLFLLLARE 296

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1361 AEELKQQVDELTAANRKAEQDMRELTYELNALQLEKTSSEEKARLLKDKLDETNNTLRclKLELERKDQAEKGYSQQLRE 1440
Cdd:COG4717  297 KASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLELLDRIEELQELLR--EAEELEEELQLEELEQEIAA 374

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1441 LgrqLNQTTGKAEEAMQEASDLKKIKRNYQLELESLNH---EKGKLQREVDRITRAHAVAEKnIQHLNSQIHSFrdEKEL 1517
Cdd:COG4717  375 L---LAEAGVEDEEELRAALEQAEEYQELKEELEELEEqleELLGELEELLEALDEEELEEE-LEELEEELEEL--EEEL 448

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4502443  1518 ERLQICQRKSDHLKEQFEKSHEqlLQNIKAEKEN-NDKIQRLNEELEKSNECAEMLKQKVEELTRQN 1583
Cdd:COG4717  449 EELREELAELEAELEQLEEDGE--LAELLQELEElKAELRELAEEWAALKLALELLEEAREEYREER 513
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 811-1273 5.73e-10

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 65.14  E-value: 5.73e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443     811 AAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLK-TVNLVLKNTQAAEalvKLYETKLCEEEAVIADKNnienliSTL 889
Cdd:pfam15921  288 SSARSQANSIQSQLEIIQEQARNQNSMYMRQLSDLEsTVSQLRSELREAK---RMYEDKIEELEKQLVLAN------SEL 358

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443     890 KQWRSEVDEKRQVFHALEDELQKAKAisdEMFKTYKERDLDfdwhKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYY 969
Cdd:pfam15921  359 TEARTERDQFSQESGNLDDQLQKLLA---DLHKREKELSLE----KEQNKRLWDRDTGNSITIDHLRRELDDRNMEVQRL 431

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443     970 RDTYHPLDDWIQ-QVETTQRKIQ-ENQP-ENSKTLATQLNQQKML----VSEIEMKQSKMDECQKYAEQYSATVKDYElq 1042
Cdd:pfam15921  432 EALLKAMKSECQgQMERQMAAIQgKNESlEKVSSLTAQLESTKEMlrkvVEELTAKKMTLESSERTVSDLTASLQEKE-- 509

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1043 tmtyRAMvdsqQKSPVKRRRMQSSADLIIQEFmdlrtrytalvtlmtQYIKFAGDSLKRLEEEEIKRCKETSEHGAYSDL 1122
Cdd:pfam15921  510 ----RAI----EATNAEITKLRSRVDLKLQEL---------------QHLKNEGDHLRNVQTECEALKLQMAEKDKVIEI 566

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1123 LQRQKATVLENSKLTGKIS---ELERMVAELKKQKSRVE-EELPKVREAAENELRKQQRNVEDISLQKIRAESEAKQYRR 1198
Cdd:pfam15921  567 LRQQIENMTQLVGQHGRTAgamQVEKAQLEKEINDRRLElQEFKILKDKKDAKIRELEARVSDLELEKVKLVNAGSERLR 646

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4502443    1199 ELETIVREKEAAERELERVRQltiEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRkdlSLNDLEQQKNKL 1273
Cdd:pfam15921  647 AVKDIKQERDQLLNEVKTSRN---ELNSLSEDYEVLKRNFRNKSEEMETTTNKLKMQLKS---AQSELEQTRNTL 715
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 747-1574 8.42e-10

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 64.60  E-value: 8.42e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443     747 RNIRLRLENCEDRLIRQIRtpLERDDLHESVFRITEQEKLKKELERLKDDLGTITN-------KCEEFFSQAaasssvPT 819
Cdd:TIGR00618   92 RTLRCTRSHRKTEQPEQLY--LEQKKGRGRILAAKKSETEEVIHDLLKLDYKTFTRvvllpqgEFAQFLKAK------SK 163

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443     820 LRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLyetklCEEEAVIADKNNIENLISTLKQWRSEVDEK 899
Cdd:TIGR00618  164 EKKELLMNLFPLDQYTQLALMEFAKKKSLHGKAELLTLRSQLLTL-----CTPCMPDTYHERKQVLEKELKHLREALQQT 238

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443     900 RQVFHALEDELQKAKAISdemfktykerdldfdwhkekadqlveRWQNVHVQIDNRLRDLEGIGKSLKyyrdtyhplddw 979
Cdd:TIGR00618  239 QQSHAYLTQKREAQEEQL--------------------------KKQQLLKQLRARIEELRAQEAVLE------------ 280

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443     980 IQQVETTQRKIQENQPENSKTLaTQLNQQKMLV-SEIemkQSKMDECQKYAEQYSATVKDyELQTMTYRAMVDSQQKSPV 1058
Cdd:TIGR00618  281 ETQERINRARKAAPLAAHIKAV-TQIEQQAQRIhTEL---QSKMRSRAKLLMKRAAHVKQ-QSSIEEQRRLLQTLHSQEI 355

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1059 KRRRMQSSADLIIQEF---MDLRTRYTAL---VTLMTQYIKFAGDSLKRLEEEEIKRCKETSEHGAysdlLQRQKATVLE 1132
Cdd:TIGR00618  356 HIRDAHEVATSIREIScqqHTLTQHIHTLqqqKTTLTQKLQSLCKELDILQREQATIDTRTSAFRD----LQGQLAHAKK 431

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1133 NSKLTGKISELERMVAELKKQKSRVEEELPKVREAAENELRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAER 1212
Cdd:TIGR00618  432 QQELQQRYAELCAAAITCTAQCEKLEKIHLQESAQSLKEREQQLQTKEQIHLQETRKKAVVLARLLELQEEPCPLCGSCI 511

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1213 ELERVRQLTIEAEA----------KRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRD 1282
Cdd:TIGR00618  512 HPNPARQDIDNPGPltrrmqrgeqTYAQLETSEEDVYHQLTSERKQRASLKEQMQEIQQSFSILTQCDNRSKEDIPNLQN 591

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1283 NEEELLKLIkQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCRENALpvcpiTQATSCRAVTGLQQEHDKQKAE 1362
Cdd:TIGR00618  592 ITVRLQDLT-EKLSEAEDMLACEQHALLRKLQPEQDLQDVRLHLQQCSQELAL-----KLTALHALQLTLTQERVREHAL 665

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1363 ELKQQVDELTAANRKAEQDM----RELTY---ELNALQLEKTSSEEKARLLKDKLDETNNTLRCLKLELERKDQAekgYS 1435
Cdd:TIGR00618  666 SIRVLPKELLASRQLALQKMqsekEQLTYwkeMLAQCQTLLRELETHIEEYDREFNEIENASSSLGSDLAAREDA---LN 742

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1436 QQLRELGRQLNQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREvdRITRAHAVAEKNIQHlNSQIHSFRDEK 1515
Cdd:TIGR00618  743 QSLKELMHQARTVLKARTEAHFNNNEEVTAALQTGAELSHLAAEIQFFNRL--REEDTHLLKTLEAEI-GQEIPSDEDIL 819

                          810       820       830       840       850
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 4502443    1516 ELERLQICQRKsDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEELEKSNECAEMLKQ 1574
Cdd:TIGR00618  820 NLQCETLVQEE-EQFLSRLEEKSATLGEITHQLLKYEECSKQLAQLTQEQAKIIQLSDK 877
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1100-1317 8.71e-10

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 63.24  E-value: 8.71e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1100 KRLEEEEIKRCKETSEHGAYSDLLQRQKATVLENSK----LTGKISELERMVAELKKQKSRVEEELPKVREAAENELRKQ 1175
Cdd:COG4942   34 QEIAELEKELAALKKEEKALLKQLAALERRIAALARriraLEQELAALEAELAELEKEIAELRAELEAQKEELAELLRAL 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1176 QRNVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLTIEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDH 1255
Cdd:COG4942  114 YRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAELEALLAELEEERAALEAL 193

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4502443  1256 LKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIEL 1317
Cdd:COG4942  194 KAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTPAAGFAALKGKL 255
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
1097-1614 1.57e-09

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 63.52  E-value: 1.57e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1097 DSLKRLEEEEIkRCKETSEhgAYSDLLQRQKATVLENSKLTGKISELERMVAELKKQKSRVEEELPKVREAAEnELRKQQ 1176
Cdd:PRK02224  220 EEIERYEEQRE-QARETRD--EADEVLEEHEERREELETLEAEIEDLRETIAETEREREELAEEVRDLRERLE-ELEEER 295

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1177 R-----------NVEDISLQKIRAESEAKQYRRELET----IVREKEAAERELERVRQLTIEAEAKR---AAVEENLLNF 1238
Cdd:PRK02224  296 DdllaeaglddaDAEAVEARREELEDRDEELRDRLEEcrvaAQAHNEEAESLREDADDLEERAEELReeaAELESELEEA 375

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1239 RNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKLIKQMEKDLafqkQVAEKQLKEKQKIeLE 1318
Cdd:PRK02224  376 REAVEDRREEIEELEEEIEELRERFGDAPVDLGNAEDFLEELREERDELREREAELEATL----RTARERVEEAEAL-LE 450

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1319 ARRkiteiqytCRENALPV--CPITQATscravtglqqEHDKQKAEELKQQVDELTAANRKAEQDMRELTyELNALQLEK 1396
Cdd:PRK02224  451 AGK--------CPECGQPVegSPHVETI----------EEDRERVEELEAELEDLEEEVEEVEERLERAE-DLVEAEDRI 511

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1397 TSSEEKARLLKDKLDETNNTLRclklelERKDQAEkgysqQLRELGRQLNQTTGKAEEAMQEASDLKKIKRNyqlELESL 1476
Cdd:PRK02224  512 ERLEERREDLEELIAERRETIE------EKRERAE-----ELRERAAELEAEAEEKREAAAEAEEEAEEARE---EVAEL 577

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1477 NHEKGKLQREVDRITRAHAVAEKnIQHLNSQIHSFRDEKELERLQICQRKsDHLKEQFEKsHEQLlqnikAEKENNDKIQ 1556
Cdd:PRK02224  578 NSKLAELKERIESLERIRTLLAA-IADAEDEIERLREKREALAELNDERR-ERLAEKRER-KREL-----EAEFDEARIE 649

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4502443   1557 RLNEELEKSNECAEMLKQKVEELTRQNNETKL---MMQRIQAESENIVLEKQTIQQRCEAL 1614
Cdd:PRK02224  650 EAREDKERAEEYLEQVEEKLDELREERDDLQAeigAVENELEELEELRERREALENRVEAL 710
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 989-1591 1.79e-09

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 63.59  E-value: 1.79e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443     989 KIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTmtyrAMVDSQQKSPVKRRrmqssaD 1068
Cdd:pfam05483  223 KIQHLEEEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKANQLEEKT----KLQDENLKELIEKK------D 292

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1069 LIIQEFMDLRT---RYTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSE-HGAYSDLLQRQKATV--------LENSKL 1136
Cdd:pfam05483  293 HLTKELEDIKMslqRSMSTQKALEEDLQIATKTICQLTEEKEAQMEELNKaKAAHSFVVTEFEATTcsleellrTEQQRL 372

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1137 TGKISELERMVAELKKQKSRVeEELPKVREAAENELRKqqrnvedisLQKIRAESEAKQY-RRELETIVREKEAAERELE 1215
Cdd:pfam05483  373 EKNEDQLKIITMELQKKSSEL-EEMTKFKNNKEVELEE---------LKKILAEDEKLLDeKKQFEKIAEELKGKEQELI 442

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1216 RVRQltiEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKLIKQME 1295
Cdd:pfam05483  443 FLLQ---AREKEIHDLEIQLTAIKTSEEHYLKEVEDLKTELEKEKLKNIELTAHCDKLLLENKELTQEASDMTLELKKHQ 519

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1296 KDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTcrenalpvcpitqatscravtglqqehdkqkAEELKQQVDELTAAN 1375
Cdd:pfam05483  520 EDIINCKKQEERMLKQIENLEEKEMNLRDELESV-------------------------------REEFIQKGDEVKCKL 568

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1376 RKAEQDMRELTYELNALQLEKTSSEEKARLLKDKLDETNNTLRCLKLE---LERKDQAEkgySQQLRELGRQLNQTTGKA 1452
Cdd:pfam05483  569 DKSEENARSIEYEVLKKEKQMKILENKCNNLKKQIENKNKNIEELHQEnkaLKKKGSAE---NKQLNAYEIKVNKLELEL 645

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1453 EEAMQEasdLKKIKRNYQLELESLNHEKGKLQREVDritRAHAVAEKNIQhLNSQIHSFRDEKELERLQICQRKSDHLKE 1532
Cdd:pfam05483  646 ASAKQK---FEEIIDNYQKEIEDKKISEEKLLEEVE---KAKAIADEAVK-LQKEIDKRCQHKIAEMVALMEKHKHQYDK 718

                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 4502443    1533 QFEKSHEQLlqNIKAEKENNDKIQRLNEELEKSNECAEMLKQKVEELTRQNNETKLMMQ 1591
Cdd:pfam05483  719 IIEERDSEL--GLYKNKEQEQSSAKAALEIELSNIKAELLSLKKQLEIEKEEKEKLKME 775
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 1213-1870 1.80e-09

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 63.45  E-value: 1.80e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1213 ELERVRQLTIEAEA--KRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKDLSlnDLEQQknkLMEELRRKRDNEEELLKL 1290
Cdd:TIGR00618  174 PLDQYTQLALMEFAkkKSLHGKAELLTLRSQLLTLCTPCMPDTYHERKQVLE--KELKH---LREALQQTQQSHAYLTQK 248

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1291 IKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQATscravtglqqEHDKQKAEELKQQVDE 1370
Cdd:TIGR00618  249 REAQEEQLKKQQLLKQLRARIEELRAQEAVLEETQERINRARKAAPLAAHIKAV----------TQIEQQAQRIHTELQS 318

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1371 ltaanrkaeqDMRELTYEL---NALQLEKTSSEEKARLLKDKLDETNNTLRCLKLELERKDQAEKGYS--QQLRELGRQL 1445
Cdd:TIGR00618  319 ----------KMRSRAKLLmkrAAHVKQQSSIEEQRRLLQTLHSQEIHIRDAHEVATSIREISCQQHTltQHIHTLQQQK 388

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1446 NQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSfrdEKELERLQICQR 1525
Cdd:TIGR00618  389 TTLTQKLQSLCKELDILQREQATIDTRTSAFRDLQGQLAHAKKQQELQQRYAELCAAAITCTAQC---EKLEKIHLQESA 465

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1526 KSDHLKEQFEKSHEQLLQniKAEKENNDKIQRLNEELEKSNECAEMLKQKVEELTRQNNETKLMMQRIQAESENIVLEKQ 1605
Cdd:TIGR00618  466 QSLKEREQQLQTKEQIHL--QETRKKAVVLARLLELQEEPCPLCGSCIHPNPARQDIDNPGPLTRRMQRGEQTYAQLETS 543

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1606 TiqqrcEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQKCDQQNiiiqNTKKEVRNLN 1685
Cdd:TIGR00618  544 E-----EDVYHQLTSERKQRASLKEQMQEIQQSFSILTQCDNRSKEDIPNLQNITVRLQDLTEKLS----EAEDMLACEQ 614

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1686 AELNASKEEKRRGEQKVQLQQAQVQELNNRL-KKVQDELHLKTIEEQMTHRKMVLFQEESGKFKQSAE-EFRKKMEKLME 1763
Cdd:TIGR00618  615 HALLRKLQPEQDLQDVRLHLQQCSQELALKLtALHALQLTLTQERVREHALSIRVLPKELLASRQLALqKMQSEKEQLTY 694

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1764 SKVITENDISGIRLDFVSLQQENSRAQENAKLCETNIKELERQ-------LQQYREQMQQGQHMEANHYQKCQKLEDELI 1836
Cdd:TIGR00618  695 WKEMLAQCQTLLRELETHIEEYDREFNEIENASSSLGSDLAARedalnqsLKELMHQARTVLKARTEAHFNNNEEVTAAL 774

                          650       660       670
                   ....*....|....*....|....*....|....*..
gi 4502443    1837 AQKREVENLKQKMDQQIKEHE---HQLVLLQCEIQKK 1870
Cdd:TIGR00618  775 QTGAELSHLAAEIQFFNRLREedtHLLKTLEAEIGQE 811
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 1423-1878 2.47e-09

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 63.32  E-value: 2.47e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1423 ELERKDQAEKGYSQQLRELGRQLNQttgKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQRevDRITRAHAVAEkniq 1502
Cdd:pfam12128  277 RQEERQETSAELNQLLRTLDDQWKE---KRDELNGELSAADAAVAKDRSELEALEDQHGAFLD--ADIETAAADQE---- 347

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1503 hlnsQIHSFRDEKEL--ERLQICQRKSDHLKEQFEKsheqLLQNIKaeKENNDKIQRLNEELEKSNECAEMLKQkVEELT 1580
Cdd:pfam12128  348 ----QLPSWQSELENleERLKALTGKHQDVTAKYNR----RRSKIK--EQNNRDIAGIKDKLAKIREARDRQLA-VAEDD 416

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1581 RQNNETKLMMQRIQAESEnivlekqtiqqrceaLKIQADGFKDQLRSTNEHLHKQTKTEQdfqrkikcLEEDLAKSQNLV 1660
Cdd:pfam12128  417 LQALESELREQLEAGKLE---------------FNEEEYRLKSRLGELKLRLNQATATPE--------LLLQLENFDERI 473

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1661 SEFKQKCDQQNiiiqntkKEVRNLNAELNASKeeKRRGEQKVQLQQAQ--VQELNNRLKKVQDELHLKTIEEQMTHRKMV 1738
Cdd:pfam12128  474 ERAREEQEAAN-------AEVERLQSELRQAR--KRRDQASEALRQASrrLEERQSALDELELQLFPQAGTLLHFLRKEA 544

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1739 LFQEES-GKFKQSAEEFRKKME-KLMESKVITENDISGIRLDFVSLQQENSRAQEN------AKLCET------NIKELE 1804
Cdd:pfam12128  545 PDWEQSiGKVISPELLHRTDLDpEVWDGSVGGELNLYGVKLDLKRIDVPEWAASEEelrerlDKAEEAlqsareKQAAAE 624

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1805 RQLQQYREQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQKMDQQIKEH-----------EHQLVLLQCEIQKKSTA 1873
Cdd:pfam12128  625 EQLVQANGELEKASREETFARTALKNARLDLRRLFDEKQSEKDKKNKALAERkdsanerlnslEAQLKQLDKKHQAWLEE 704


                   ....*
gi 4502443    1874 KDCTF 1878
Cdd:pfam12128  705 QKEQK 709
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
883-1326 6.60e-09

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 61.32  E-value: 6.60e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   883 ENLISTLKQWRSEVDEKRQV---FHALEDELQKAKAISDEMFKTYKERDLDFDwHKEKADQLVERWQNVHvQIDNRLRDL 959
Cdd:COG4717   67 ELNLKELKELEEELKEAEEKeeeYAELQEELEELEEELEELEAELEELREELE-KLEKLLQLLPLYQELE-ALEAELAEL 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   960 EGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQE--------NQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQ 1031
Cdd:COG4717  145 PERLEELEERLEELRELEEELEELEAELAELQEeleelleqLSLATEEELQDLAEELEELQQRLAELEEELEEAQEELEE 224

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1032 YSATVKDYELQtmtyrAMVDSQQKSPVKRRRMQSSADLII------QEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEE 1105
Cdd:COG4717  225 LEEELEQLENE-----LEAAALEERLKEARLLLLIAAALLallglgGSLLSLILTIAGVLFLVLGLLALLFLLLAREKAS 299

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1106 EIKRCKETSEHGAYSDLLQRQKATVLENSKLTGKIS-----ELERMVAELKKQKSRVEEELpkvREAAENELRKQQRNVe 1180
Cdd:COG4717  300 LGKEAEELQALPALEELEEEELEELLAALGLPPDLSpeellELLDRIEELQELLREAEELE---EELQLEELEQEIAAL- 375

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1181 disLQKIRAESEAkqyrrELETIVREKEAAERELERVRQLTIEAEAKRAAVEENLlnfrnqleeNTFTRRTLEDHLKRKD 1260
Cdd:COG4717  376 ---LAEAGVEDEE-----ELRAALEQAEEYQELKEELEELEEQLEELLGELEELL---------EALDEEELEEELEELE 438

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4502443  1261 LSLNDLEQQKNKLMEELRrkrdneeELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEI 1326
Cdd:COG4717  439 EELEELEEELEELREELA-------ELEAELEQLEEDGELAELLQELEELKAELRELAEEWAALKL 497
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
1104-1586 6.64e-09

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 61.59  E-value: 6.64e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1104 EEEIKRCKET-----SEHGAYSDLLQRQKATVLE-NSKLTGKISE----------LERMVAELKKQKSRVEEELPKVREA 1167
Cdd:PRK02224  257 EAEIEDLRETiaeteREREELAEEVRDLRERLEElEEERDDLLAEaglddadaeaVEARREELEDRDEELRDRLEECRVA 336

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1168 AENELRKQQRNVEDISlqkiRAESEAKQYRRELETIVREKEAAERELErvrqltiEAEAKRAAVEENLLNFRNQLEENTF 1247
Cdd:PRK02224  337 AQAHNEEAESLREDAD----DLEERAEELREEAAELESELEEAREAVE-------DRREEIEELEEEIEELRERFGDAPV 405

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1248 TRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKLIK-----QMEKDLAFQKQVAEKQLKEKQKIELEARRK 1322
Cdd:PRK02224  406 DLGNAEDFLEELREERDELREREAELEATLRTARERVEEAEALLEagkcpECGQPVEGSPHVETIEEDRERVEELEAELE 485

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1323 ITEIQYTCRENALPVCPITQATSCRAVTGLQQ---------------EHDKQKAEELKQQVDELTAANRKAE-------- 1379
Cdd:PRK02224  486 DLEEEVEEVEERLERAEDLVEAEDRIERLEERredleeliaerretiEEKRERAEELRERAAELEAEAEEKReaaaeaee 565

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1380 --QDMRELTYELNALQLEKTSSEEKARLLKDKLDE-TNNTLRCLKLELERKDQAE-----KGYSQQLRELGRQLNQTTGK 1451
Cdd:PRK02224  566 eaEEAREEVAELNSKLAELKERIESLERIRTLLAAiADAEDEIERLREKREALAElnderRERLAEKRERKRELEAEFDE 645

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1452 A--EEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRItrahavaekniqhlnsqihsfrdEKELERLQICQRKSDH 1529
Cdd:PRK02224  646 AriEEAREDKERAEEYLEQVEEKLDELREERDDLQAEIGAV-----------------------ENELEELEELRERREA 702

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 4502443   1530 LKEQFEKsheqllqnIKAEKENNDKIQRLNEELEksnecAEMLKQKVEELTRQNNET 1586
Cdd:PRK02224  703 LENRVEA--------LEALYDEAEELESMYGDLR-----AELRQRNVETLERMLNET 746
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 1142-1487 9.86e-09

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 60.91  E-value: 9.86e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1142 ELERMVAE-LKKQKSRVEEELPKVREAAENElrkQQRNVEDISLQKIRAESE--AKQYRRELETIvrEKEAAERELERVR 1218
Cdd:pfam17380  292 KFEKMEQErLRQEKEEKAREVERRRKLEEAE---KARQAEMDRQAAIYAEQErmAMERERELERI--RQEERKRELERIR 366

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1219 QLTIEAEAKRAAVEENLLNFRNQleENTFTRRTLEDHLKRKDL--SLNDLEQQKNKLMEELRRKRDN--EEELLKLIKQM 1294
Cdd:pfam17380  367 QEEIAMEISRMRELERLQMERQQ--KNERVRQELEAARKVKILeeERQRKIQQQKVEMEQIRAEQEEarQREVRRLEEER 444

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1295 EKDLafqKQVAEKQLKEKQKIEL------EARRKITEIQytcrenalpvcpitqatscravtglQQEHDKQKAEELKQQV 1368
Cdd:pfam17380  445 AREM---ERVRLEEQERQQQVERlrqqeeERKRKKLELE-------------------------KEKRDRKRAEEQRRKI 496

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1369 DELTAANRKaeQDMREltyelnalqlektsSEEKARLLKDKLDETNNTlrcLKLELERKDQAEKGYSQQLRELGRQLNQT 1448
Cdd:pfam17380  497 LEKELEERK--QAMIE--------------EERKRKLLEKEMEERQKA---IYEEERRREAEEERRKQQEMEERRRIQEQ 557

                          330       340       350
                   ....*....|....*....|....*....|....*....
gi 4502443    1449 TGKAEEamqEASDLKKIKRNYQLELESLNHEKGKLQREV 1487
Cdd:pfam17380  558 MRKATE---ERSRLEAMEREREMMRQIVESEKARAEYEA 593
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 1502-1810 1.28e-08

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 60.52  E-value: 1.28e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1502 QHLNSQIHSFRDEKEL-ERLQicqrksdhlKEQFEKSHEQLLQNIKAEKENNDKIQRLNEELEKSNEcAEMLKQ------ 1574
Cdd:pfam17380  269 EFLNQLLHIVQHQKAVsERQQ---------QEKFEKMEQERLRQEKEEKAREVERRRKLEEAEKARQ-AEMDRQaaiyae 338

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1575 -------KVEELTR-QNNETKLMMQRIQAES-----------ENIVLEKQT----IQQRCEALKIQADGFKDQLRSTNEH 1631
Cdd:pfam17380  339 qermameRERELERiRQEERKRELERIRQEEiameisrmrelERLQMERQQknerVRQELEAARKVKILEEERQRKIQQQ 418

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1632 LHKQTKT----EQDFQRKIKCLEEDLAKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLNAELNasKEEKRRGEQKVQLQQA 1707
Cdd:pfam17380  419 KVEMEQIraeqEEARQREVRRLEEERAREMERVRLEEQERQQQVERLRQQEEERKRKKLELE--KEKRDRKRAEEQRRKI 496

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1708 QVQELN-NRLKKVQDELHLKTIEEQMTHRKMVLFQEESgkfKQSAEEFRKKMEKLMESKVITEndisgiRLDFVSLQQEN 1786
Cdd:pfam17380  497 LEKELEeRKQAMIEEERKRKLLEKEMEERQKAIYEEER---RREAEEERRKQQEMEERRRIQE------QMRKATEERSR 567

                          330       340
                   ....*....|....*....|....
gi 4502443    1787 SRAQENAKLCETNIKELERQLQQY 1810
Cdd:pfam17380  568 LEAMEREREMMRQIVESEKARAEY 591
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 2244-2282 1.76e-08

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 459901  Cd Length: 39  Bit Score: 52.33  E-value: 1.76e-08
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 4502443    2244 ILEAQIASGGVIDPVRGIRVPPEIALQQGLLNNAILQFL 2282
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQKL 39
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1635-1855 2.08e-08

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 59.01  E-value: 2.08e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1635 QTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQLQQAQVQELNN 1714
Cdd:COG4942   18 QADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRA 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1715 RLKKVQDELHLKTIEEQMTHR----KMVLFQEESGKFKQSAEEFRKKMEKLMEskvitenDISGIRLDFVSLQQENSRAQ 1790
Cdd:COG4942   98 ELEAQKEELAELLRALYRLGRqpplALLLSPEDFLDAVRRLQYLKYLAPARRE-------QAEELRADLAELAALRAELE 170

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4502443  1791 ENAKLCETNIKELERQLQQYREQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQKMDQQIKE 1855
Cdd:COG4942  171 AERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAE 235
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
 2556-2593 4.77e-08

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 459901  Cd Length: 39  Bit Score: 50.79  E-value: 4.77e-08
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 4502443    2556 LEFQYLTGGLIEPQVHSRLSIEEALQVGIIDVLIATKL 2593
Cdd:pfam00681    2 LEAQAATGGIIDPVTGERLSVEEAVKRGLIDPETAQKL 39
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
761-1326 4.85e-08

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 58.92  E-value: 4.85e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    761 IRQ--IRTPLERDDLHESVFR-ITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVL-QNMNQVYS 836
Cdd:PRK03918  132 IRQgeIDAILESDESREKVVRqILGLDDYENAYKNLGEVIKEIKRRIERLEKFIKRTENIEELIKEKEKELeEVLREINE 211

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    837 MSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAI 916
Cdd:PRK03918  212 ISSELPELREELEKLEKEVKELEELKEEIEELEKELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKVKELKELKEK 291

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    917 SDEMFKTYKERDlDFDWHKEKADQLVERWQNVHVQIDNRLRDLEG-------IGKSLKYYRDTYHPLDDWIQQVETTQRK 989
Cdd:PRK03918  292 AEEYIKLSEFYE-EYLDELREIEKRLSRLEEEINGIEERIKELEEkeerleeLKKKLKELEKRLEELEERHELYEEAKAK 370

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    990 iqENQPENSKTLATQLNQQKmLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVD----SQQKSPVKRRrmqs 1065
Cdd:PRK03918  371 --KEELERLKKRLTGLTPEK-LEKELEELEKAKEEIEEEISKITARIGELKKEIKELKKAIEelkkAKGKCPVCGR---- 443

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1066 saDLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEHGAYSDLLQ--------------------R 1125
Cdd:PRK03918  444 --ELTEEHRKELLEEYTAELKRIEKELKEIEEKERKLRKELRELEKVLKKESELIKLKElaeqlkeleeklkkynleelE 521

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1126 QKATVLENSK-----LTGKISELERMV---AELKKQKSRVEEELPKVREAAENELRK-QQRNVEDISLQKIRAESEAKQY 1196
Cdd:PRK03918  522 KKAEEYEKLKeklikLKGEIKSLKKELeklEELKKKLAELEKKLDELEEELAELLKElEELGFESVEELEERLKELEPFY 601

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1197 RR--ELETIVREKEAAERELERVRQLTIEAEAKRAAVEENLLNFRNQLEE--------------NTFTRrtLEDHLKRKD 1260
Cdd:PRK03918  602 NEylELKDAEKELEREEKELKKLEEELDKAFEELAETEKRLEELRKELEElekkyseeeyeelrEEYLE--LSRELAGLR 679

                         570       580       590       600       610       620
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4502443   1261 LSLNDLEQQKN---KLMEELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEI 1326
Cdd:PRK03918  680 AELEELEKRREeikKTLEKLKEELEEREKAKKELEKLEKALERVEELREKVKKYKALLKERALSKVGEI 748
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 1103-1817 5.14e-08

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 58.65  E-value: 5.14e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1103 EEEEIKRC--KETSEHGA-YSDLLQRQKATVLEnskLTGKISELERMVAELKKQKSRVEEElpkvreaaENELRKQQRnv 1179
Cdd:pfam01576  328 EVTELKKAleEETRSHEAqLQEMRQKHTQALEE---LTEQLEQAKRNKANLEKAKQALESE--------NAELQAELR-- 394

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1180 ediSLQKIRAESEAKqyRRELETIVREKEAAERELERVRQLTIEAEAKRAAVEENLLNFRNQLEENTFTRR----TLEDH 1255
Cdd:pfam01576  395 ---TLQQAKQDSEHK--RKKLEGQLQELQARLSESERQRAELAEKLSKLQSELESVSSLLNEAEGKNIKLSkdvsSLESQ 469

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1256 LKRKDLSLNDLEQQKNKLMEELRRKrdnEEELLKLIKQMEKDLAfQKQVAEKQLKEKQKIELEARRKITEIQYTcrenal 1335
Cdd:pfam01576  470 LQDTQELLQEETRQKLNLSTRLRQL---EDERNSLQEQLEEEEE-AKRNVERQLSTLQAQLSDMKKKLEEDAGT------ 539

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1336 pvcpITQATSCRAVTGLQQEHDKQKAEELKQQVDELTAANRKAEQDMRELTYELNALQLEKTSSEEKARLLKDKLDETNN 1415
Cdd:pfam01576  540 ----LEALEEGKKRLQRELEALTQQLEEKAAAYDKLEKTKNRLQQELDDLLVDLDHQRQLVSNLEKKQKKFDQMLAEEKA 615

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1416 TlrCLKLELERkDQAEKgysqQLRELGRQLNQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRITRAHA 1495
Cdd:pfam01576  616 I--SARYAEER-DRAEA----EAREKETRALSLARALEEALEAKEELERTNKQLRAEMEDLVSSKDDVGKNVHELERSKR 688

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1496 VAEKNIQHLNSQIHSFRDE---KELERLQIcQRKSDHLKEQFEKSheqlLQNikAEKENNDKIQRLNEEL-EKSNECAEM 1571
Cdd:pfam01576  689 ALEQQVEEMKTQLEELEDElqaTEDAKLRL-EVNMQALKAQFERD----LQA--RDEQGEEKRRQLVKQVrELEAELEDE 761

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1572 LKQKVEELT-RQNNETKLMMQRIQAESENIVLEKQTIQQRcealKIQADgFKDQLRSTNEHLHKQTK---TEQDFQRKIK 1647
Cdd:pfam01576  762 RKQRAQAVAaKKKLELDLKELEAQIDAANKGREEAVKQLK----KLQAQ-MKDLQRELEEARASRDEilaQSKESEKKLK 836

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1648 CLE-------EDLAKSQNLVSEFKQKCDQqniiiqnTKKEVRNLNAELNASKEEKRRGEQKV-QLQ------QAQVQELN 1713
Cdd:pfam01576  837 NLEaellqlqEDLAASERARRQAQQERDE-------LADEIASGASGKSALQDEKRRLEARIaQLEeeleeeQSNTELLN 909

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1714 NRLKKVQdeLHLKTIEEQMTHRKMVLFQEESGK--FKQSAEEFRKKMEKlMESKVITE--NDISGIRLDFVS----LQQE 1785
Cdd:pfam01576  910 DRLRKST--LQVEQLTTELAAERSTSQKSESARqqLERQNKELKAKLQE-MEGTVKSKfkSSIAALEAKIAQleeqLEQE 986

                          730       740       750       760
                   ....*....|....*....|....*....|....*....|..
gi 4502443    1786 NSRAQENAKLC---ETNIKEL-------ERQLQQYREQMQQG 1817
Cdd:pfam01576  987 SRERQAANKLVrrtEKKLKEVllqvedeRRHADQYKDQAEKG 1028
PLEC smart00250
Plectin repeat;
2170-2205 7.05e-08

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 50.56  E-value: 7.05e-08
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 4502443     2170 FLEAQAATGFIIDPISGQTYSVEDAVLKGVVDPEFR 2205
Cdd:smart00250    3 LLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
PLEC smart00250
Plectin repeat;
2477-2514 9.55e-08

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 50.17  E-value: 9.55e-08
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 4502443     2477 LRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFA 2514
Cdd:smart00250    1 QRLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 620-1854 9.62e-08

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 58.14  E-value: 9.62e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443     620 KEAVDLANRIEQqyqnvltlwHESHINMKSVVSwHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLedsQE 699
Cdd:TIGR01612  620 KKAIDLKKIIEN---------NNAYIDELAKIS-PYQVPEHLKNKDKIYSTIKSELSKIYEDDIDALYNELSSIV---KE 686

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443     700 SQVFSGSDITQLEKEVNVCKQYYQELlksaerEEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDdLHESV-- 777
Cdd:TIGR01612  687 NAIDNTEDKAKLDDLKSKIDKEYDKI------QNMETATVELHLSNIENKKNELLDIIVEIKKHIHGEINKD-LNKILed 759

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443     778 FRITEQEKLKK--ELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSElnvvlqNMNQVYSMSSTYIdklKTVNLvlknt 855
Cdd:TIGR01612  760 FKNKEKELSNKinDYAKEKDELNKYKSKISEIKNHYNDQINIDNIKDE------DAKQNYDKSKEYI---KTISI----- 825

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443     856 QAAEALVKLYETKLCEEEAViadkNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAkaISDEMFKTYKERDLDF-DWH 934
Cdd:TIGR01612  826 KEDEIFKIINEMKFMKDDFL----NKVDKFINFENNCKEKIDSEHEQFAELTNKIKAE--ISDDKLNDYEKKFNDSkSLI 899

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443     935 KEKADQLVERWQNVHV--QIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQ-VETTQ-----RKIQENQPENskTLATQLN 1006
Cdd:TIGR01612  900 NEINKSIEEEYQNINTlkKVDEYIKICENTKESIEKFHNKQNILKEILNKnIDTIKesnliEKSYKDKFDN--TLIDKIN 977

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1007 QQKMLVSEIEMK--QSKMDECQKYAEQYSATVKDYELQTMTY------RAMVDSQQKSpVKRRRMQSSADLIIqefmdlr 1078
Cdd:TIGR01612  978 ELDKAFKDASLNdyEAKNNELIKYFNDLKANLGKNKENMLYHqfdekeKATNDIEQKI-EDANKNIPNIEIAI------- 1049

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1079 trYTALVTLMTQYIKFAGDSLKRLEEEEIKRC----------KETSEHGAYSDLLQRqkatvlENSKLTGKISELERMVA 1148
Cdd:TIGR01612 1050 --HTSIYNIIDEIEKEIGKNIELLNKEILEEAeinitnfneiKEKLKHYNFDDFGKE------ENIKYADEINKIKDDIK 1121

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1149 ELKKQKSRVEEELPKVREAAEN---ELRKQQRNVEDISLQKIRAEsEAKQYRRELETIVREKEaaerelervrqltieae 1225
Cdd:TIGR01612 1122 NLDQKIDHHIKALEEIKKKSENyidEIKAQINDLEDVADKAISND-DPEEIEKKIENIVTKID----------------- 1183

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1226 aKRAAVEENLLNFRNQLEENTFTRRTLEdhlKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKLIKQMEKDL-AFQKQV 1304
Cdd:TIGR01612 1184 -KKKNIYDEIKKLLNEIAEIEKDKTSLE---EVKGINLSYGKNLGKLFLEKIDEEKKKSEHMIKAMEAYIEDLdEIKEKS 1259

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1305 AEKQLKEKQKIELEARRKITEIQYTCRENALPVcpitqatscravtglQQEHDKQkAEELKQQVDELTAANRKaEQDMRE 1384
Cdd:TIGR01612 1260 PEIENEMGIEMDIKAEMETFNISHDDDKDHHII---------------SKKHDEN-ISDIREKSLKIIEDFSE-ESDIND 1322

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1385 LTYEL--NALQLEKTSSEekarlLKDKLDETNNTLRCLKLELERKDQAE-KGYSQQLRELGRQLNQTTGKAEEAmqeasd 1461
Cdd:TIGR01612 1323 IKKELqkNLLDAQKHNSD-----INLYLNEIANIYNILKLNKIKKIIDEvKEYTKEIEENNKNIKDELDKSEKL------ 1391

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1462 LKKIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHS-FRDEKE--------LERLQICQRKSDH-LK 1531
Cdd:TIGR01612 1392 IKKIKDDINLEECKSKIESTLDDKDIDECIKKIKELKNHILSEESNIDTyFKNADEnnenvlllFKNIEMADNKSQHiLK 1471

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1532 EQFEKSHEQLLQNIKAEKENNDKIQRLNEE-------LEKSNECAEMLKQKVEEL-------------TRQNNETKLMMQ 1591
Cdd:TIGR01612 1472 IKKDNATNDHDFNINELKEHIDKSKGCKDEadknakaIEKNKELFEQYKKDVTELlnkysalaiknkfAKTKKDSEIIIK 1551

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1592 RIQAESENIVLEKQTIQQRCEALKIQADGFKDQLRSTNehlhKQTKTEQDFQRKIKCLEEDLAKsqnlVSEFKQKcdqqn 1671
Cdd:TIGR01612 1552 EIKDAHKKFILEAEKSEQKIKEIKKEKFRIEDDAAKND----KSNKAAIDIQLSLENFENKFLK----ISDIKKK----- 1618

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1672 iiIQNTKKEVRNLnaelnaskeEKRRGEQKVQLQQAQVQELNNRLKKVQDelHLKTIEEQmthrkmvlfqeesgkfKQSA 1751
Cdd:TIGR01612 1619 --INDCLKETESI---------EKKISSFSIDSQDTELKENGDNLNSLQE--FLESLKDQ----------------KKNI 1669

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1752 EEFRKKMEKLmeskvitendisgirldfvslqqensraqenaklcETNIKELERQLQQYREQMQQGqhmeanhyqKCQKL 1831
Cdd:TIGR01612 1670 EDKKKELDEL-----------------------------------DSEIEKIEIDVDQHKKNYEIG---------IIEKI 1705

                         1290      1300
                   ....*....|....*....|...
gi 4502443    1832 EDELIAQKREVENLKQKMDQQIK 1854
Cdd:TIGR01612 1706 KEIAIANKEEIESIKELIEPTIE 1728
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1136-1455 3.95e-07

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 56.08  E-value: 3.95e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1136 LTGKISELERMVAELKKQKSRVEEELPKVREAAENELRKQQRNVEDISLQKIRAESEAKQYRRE--------LETIVREK 1207
Cdd:COG4913  615 LEAELAELEEELAEAEERLEALEAELDALQERREALQRLAEYSWDEIDVASAEREIAELEAELErldassddLAALEEQL 694

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1208 EAAERELERVRQLTIEAEAKRAAVEENLLNFRNQLEENtftRRTLEDHLKRKDLSLN-DLEQQKNKLMEELRRKRdneee 1286
Cdd:COG4913  695 EELEAELEELEEELDELKGEIGRLEKELEQAEEELDEL---QDRLEAAEDLARLELRaLLEERFAAALGDAVERE----- 766

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1287 llklikqMEKDLAFQKQVAEKQLKEKQKielEARRKITEIQytcreNALPVCPITQATSCRAVTGLQQEHDKQKAEELKQ 1366
Cdd:COG4913  767 -------LRENLEERIDALRARLNRAEE---ELERAMRAFN-----REWPAETADLDADLESLPEYLALLDRLEEDGLPE 831

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1367 QVDELTAA-NRKAEQDMRELTYELnalqlektssEEKARLLKDKLDETNNTL--------RCLKLELE-RKDQAEKGYSQ 1436
Cdd:COG4913  832 YEERFKELlNENSIEFVADLLSKL----------RRAIREIKERIDPLNDSLkripfgpgRYLRLEARpRPDPEVREFRQ 901

                        330
                 ....*....|....*....
gi 4502443  1437 QLRELGRQLNQTTGKAEEA 1455
Cdd:COG4913  902 ELRAVTSGASLFDEELSEA 920
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1359-1584 4.48e-07

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 55.69  E-value: 4.48e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1359 QKAEELKQQVDELTAAN------RKAEQDMRELTYELNALQLEKtsSEEKARLLKDKLDETNNTLRCLKLELERKDQAEK 1432
Cdd:COG4913  242 EALEDAREQIELLEPIRelaeryAAARERLAELEYLRAALRLWF--AQRRLELLEAELEELRAELARLEAELERLEARLD 319

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1433 GYSQQLRELGRQLNQTTGKaeeamqeasdlkkikrnyqlELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSfr 1512
Cdd:COG4913  320 ALREELDELEAQIRGNGGD--------------------RLEQLEREIERLERELEERERRRARLEALLAALGLPLPA-- 377

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4502443  1513 DEKELERLqicQRKSDHLKEQFEKSHEQLLQnikAEKENNDKIQRLNEELEKsnecaemLKQKVEELTRQNN 1584
Cdd:COG4913  378 SAEEFAAL---RAEAAALLEALEEELEALEE---ALAEAEAALRDLRRELRE-------LEAEIASLERRKS 436
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 1117-1723 5.74e-07

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 55.57  E-value: 5.74e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1117 GAYSDLLQRQKATVLENSKLTGKISELERMVAELKKQKSRVEEELPKVR---EAAENELRKQQRNVEDISLQKIRAES-- 1191
Cdd:pfam01576  398 QAKQDSEHKRKKLEGQLQELQARLSESERQRAELAEKLSKLQSELESVSsllNEAEGKNIKLSKDVSSLESQLQDTQEll 477

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1192 -EAKQYRRELETIVREKEAAERELErvRQLTIEAEAKRAA------VEENLLNFRNQLEENTFTRRTLEDHLKR------ 1258
Cdd:pfam01576  478 qEETRQKLNLSTRLRQLEDERNSLQ--EQLEEEEEAKRNVerqlstLQAQLSDMKKKLEEDAGTLEALEEGKKRlqrele 555

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1259 --------KDLSLNDLEQQKNKLMEELR-------RKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARRKI 1323
Cdd:pfam01576  556 altqqleeKAAAYDKLEKTKNRLQQELDdllvdldHQRQLVSNLEKKQKKFDQMLAEEKAISARYAEERDRAEAEAREKE 635

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1324 TEIQYTCRenALPVCPITQATSCRAVTGLQQEHDK--QKAEELKQQVDELTAANRKAEQDMRELTYELNALQLEKTSSEE 1401
Cdd:pfam01576  636 TRALSLAR--ALEEALEAKEELERTNKQLRAEMEDlvSSKDDVGKNVHELERSKRALEQQVEEMKTQLEELEDELQATED 713

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1402 -KARLlkdkldETNntLRCLKLELERKDQA--EKGySQQLRELGRQLNQTTGKAEEAMQEASDLKKIKRNYQLELESLNH 1478
Cdd:pfam01576  714 aKLRL------EVN--MQALKAQFERDLQArdEQG-EEKRRQLVKQVRELEAELEDERKQRAQAVAAKKKLELDLKELEA 784

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1479 E-----KGK----------------LQREVD--RITRAHAVA-----EKNIQHLnsqihsfrdEKELERLQICQRKSDHL 1530
Cdd:pfam01576  785 QidaanKGReeavkqlkklqaqmkdLQRELEeaRASRDEILAqskesEKKLKNL---------EAELLQLQEDLAASERA 855

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1531 KEQFEKSHEQLLQNIKAEKENN-----------DKIQRLNEELEKSNECAEMLKQKVEELTRQNNEtklMMQRIQAEsen 1599
Cdd:pfam01576  856 RRQAQQERDELADEIASGASGKsalqdekrrleARIAQLEEELEEEQSNTELLNDRLRKSTLQVEQ---LTTELAAE--- 929

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1600 ivlekQTIQQRCEALKIQADGFKDQLRSTNEHLHKQTKTEqdFQRKIKCLEEDLAKSQNLVSEFKQKCDQQNIIIQNTKK 1679
Cdd:pfam01576  930 -----RSTSQKSESARQQLERQNKELKAKLQEMEGTVKSK--FKSSIAALEAKIAQLEEQLEQESRERQAANKLVRRTEK 1002

                          650       660       670       680
                   ....*....|....*....|....*....|....*....|....
gi 4502443    1680 EVRNLnaeLNASKEEKRRGEQkvqlQQAQVQELNNRLKKVQDEL 1723
Cdd:pfam01576 1003 KLKEV---LLQVEDERRHADQ----YKDQAEKGNSRMKQLKRQL 1039
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 1358-1875 7.53e-07

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 54.97  E-value: 7.53e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1358 KQKAEELKQQVDELTAANrKAEQDMRELTYELNALQLEKTSSEEKARLLKDKLDETNNTLRCLKLELERKDQAEKGYSQQ 1437
Cdd:TIGR00618  159 KAKSKEKKELLMNLFPLD-QYTQLALMEFAKKKSLHGKAELLTLRSQLLTLCTPCMPDTYHERKQVLEKELKHLREALQQ 237

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1438 LRELGRQLNQTTGKAEEAMQEASDLKKIKRNYQlELESLNHEKGKLQREVDRITRAHAVAE--KNIQHLNSQ---IHSFR 1512
Cdd:TIGR00618  238 TQQSHAYLTQKREAQEEQLKKQQLLKQLRARIE-ELRAQEAVLEETQERINRARKAAPLAAhiKAVTQIEQQaqrIHTEL 316

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1513 DEKELERLQICQRKSDHLKEQFEKSHEQLLQNikaekenndKIQRLNEELEKSNECAEMLKqkvEELTRQNNETklmmQR 1592
Cdd:TIGR00618  317 QSKMRSRAKLLMKRAAHVKQQSSIEEQRRLLQ---------TLHSQEIHIRDAHEVATSIR---EISCQQHTLT----QH 380

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1593 IQAESENIVLEKQTIQQRCEALkiqadgfkDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQnlvsefkQKCDQQNI 1672
Cdd:TIGR00618  381 IHTLQQQKTTLTQKLQSLCKEL--------DILQREQATIDTRTSAFRDLQGQLAHAKKQQELQQ-------RYAELCAA 445

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1673 IIQNTKKEVRNLNAELNASKEEKRrgEQKVQLQQAQVQELNNRLKKvqdELHLKTIEEQmthrkmvlfQEESGKFKQSAE 1752
Cdd:TIGR00618  446 AITCTAQCEKLEKIHLQESAQSLK--EREQQLQTKEQIHLQETRKK---AVVLARLLEL---------QEEPCPLCGSCI 511

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1753 EFRKKMEKLMESKVITENDISGIrldfvslqQENSRAQENAKLCETNIKELERQLQQYREQMQQGQHMEANHYQKCQKLE 1832
Cdd:TIGR00618  512 HPNPARQDIDNPGPLTRRMQRGE--------QTYAQLETSEEDVYHQLTSERKQRASLKEQMQEIQQSFSILTQCDNRSK 583

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|...
gi 4502443    1833 DELIAQKREVENLKQKMDQQIKEHEHQLVLLQCEIQKKSTAKD 1875
Cdd:TIGR00618  584 EDIPNLQNITVRLQDLTEKLSEAEDMLACEQHALLRKLQPEQD 626
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 785-1851 8.04e-07

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 55.06  E-value: 8.04e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443     785 KLKKELERLKDDLGTITNKCEEFFSQAAASSS----VPTLRSELNVVLQNMnqvySMSSTYIDKLKTVNLVLKNTQAaea 860
Cdd:TIGR01612  562 EIKKELEEENEDSIHLEKEIKDLFDKYLEIDDeiiyINKLKLELKEKIKNI----SDKNEYIKKAIDLKKIIENNNA--- 634

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443     861 lvklyetkLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFhalEDELQKakaISDEMFKTYKERDLDFDWHKEKADQ 940
Cdd:TIGR01612  635 --------YIDELAKISPYQVPEHLKNKDKIYSTIKSELSKIY---EDDIDA---LYNELSSIVKENAIDNTEDKAKLDD 700

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443     941 LVERWQNVHVQIDNRlrDLEGIGKSLKYYRDTYHPLDDWIqqVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQS 1020
Cdd:TIGR01612  701 LKSKIDKEYDKIQNM--ETATVELHLSNIENKKNELLDII--VEIKKHIHGEINKDLNKILEDFKNKEKELSNKINDYAK 776

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1021 KMDECQKYAEQYSATVKDYELQTMtyramVDSQQKSPVKRRRMQSSadliiqefmdlrtRYTALVTLMTQYIKFAGDSLK 1100
Cdd:TIGR01612  777 EKDELNKYKSKISEIKNHYNDQIN-----IDNIKDEDAKQNYDKSK-------------EYIKTISIKEDEIFKIINEMK 838

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1101 RLEEEEIKR----------CKET--SEHGAYSDLLQRQKATVLEN--SKLTGKISELERMVAELKKQksrVEEELPKVre 1166
Cdd:TIGR01612  839 FMKDDFLNKvdkfinfennCKEKidSEHEQFAELTNKIKAEISDDklNDYEKKFNDSKSLINEINKS---IEEEYQNI-- 913

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1167 aaeNELRKQqrnveDISLQKIRAESEAKQYRRELETIVREKeaAERELERVRqltieaeakraavEENLL--NFRNQLEe 1244
Cdd:TIGR01612  914 ---NTLKKV-----DEYIKICENTKESIEKFHNKQNILKEI--LNKNIDTIK-------------ESNLIekSYKDKFD- 969

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1245 NTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDN-----EEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEA 1319
Cdd:TIGR01612  970 NTLIDKINELDKAFKDASLNDYEAKNNELIKYFNDLKANlgknkENMLYHQFDEKEKATNDIEQKIEDANKNIPNIEIAI 1049

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1320 RRKI-------------------TEIQYTCRENALPVCPITQATSCRAVTGLQQEHDKQKAEE----------LKQQVD- 1369
Cdd:TIGR01612 1050 HTSIyniideiekeigkniellnKEILEEAEINITNFNEIKEKLKHYNFDDFGKEENIKYADEinkikddiknLDQKIDh 1129

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1370 ---ELTAANRKAEQDMRELTYELNALQ--LEKTSS-------EEKARLLKDKLDETNNTLRCLKLELERKDQAEK----- 1432
Cdd:TIGR01612 1130 hikALEEIKKKSENYIDEIKAQINDLEdvADKAISnddpeeiEKKIENIVTKIDKKKNIYDEIKKLLNEIAEIEKdktsl 1209

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1433 --------GYSQQLRELG-RQLNQTTGKAE---EAMQE-ASDLKKIKRNYQlELESLNHEKGKLQREVDRITRAHAVAEK 1499
Cdd:TIGR01612 1210 eevkginlSYGKNLGKLFlEKIDEEKKKSEhmiKAMEAyIEDLDEIKEKSP-EIENEMGIEMDIKAEMETFNISHDDDKD 1288

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1500 niQHLNSQIH--SFRD--EKELERLQICQRKSD--HLKEQFEKSHeqllqnIKAEKENNDKIQRLNE--------ELEKS 1565
Cdd:TIGR01612 1289 --HHIISKKHdeNISDirEKSLKIIEDFSEESDinDIKKELQKNL------LDAQKHNSDINLYLNEianiynilKLNKI 1360

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1566 NECAEMLKQKVEELTRQNNETKLMMQR----IQAESENIVLE--KQTIQQRCEALKIQaDGFKDQLRSTNEHLHKQTKTE 1639
Cdd:TIGR01612 1361 KKIIDEVKEYTKEIEENNKNIKDELDKseklIKKIKDDINLEecKSKIESTLDDKDID-ECIKKIKELKNHILSEESNID 1439

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1640 QDFQRK----------IKCLEEDLAKSQNL---------------VSEFKQKCDQQNIIIQNTKKEVRNLnaELNASKEE 1694
Cdd:TIGR01612 1440 TYFKNAdennenvlllFKNIEMADNKSQHIlkikkdnatndhdfnINELKEHIDKSKGCKDEADKNAKAI--EKNKELFE 1517

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1695 KRRGEQKVQLQQAQVQELNNRLKKVQDELHLKTIEEQMTHRKMVLfqeESGKFKQSAEEFRKkmEKLMESKVITENDIS- 1773
Cdd:TIGR01612 1518 QYKKDVTELLNKYSALAIKNKFAKTKKDSEIIIKEIKDAHKKFIL---EAEKSEQKIKEIKK--EKFRIEDDAAKNDKSn 1592

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1774 ----GIRLDFVSLQQE-----NSRAQENAKLCETniKELERQLQQYREQMQQGQHME-ANHYQKCQKLEDELIAQKREVE 1843
Cdd:TIGR01612 1593 kaaiDIQLSLENFENKflkisDIKKKINDCLKET--ESIEKKISSFSIDSQDTELKEnGDNLNSLQEFLESLKDQKKNIE 1670


                   ....*...
gi 4502443    1844 NLKQKMDQ 1851
Cdd:TIGR01612 1671 DKKKELDE 1678
SPEC smart00150
Spectrin repeats;
282-373 8.73e-07

Spectrin repeats;


Pssm-ID: 197544 [Multi-domain]  Cd Length: 101  Bit Score: 49.25  E-value: 8.73e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443      282 VQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTA---PLKLTYAEKLHRLESQY 358
Cdd:smart00150    7 ADELEAWLEEKEQLLASEDLGKDLESVEALLKKHEAFEAELEAHEERVEALNELGEQLIEeghPDAEEIEERLEELNERW 86

                            90
                    ....*....|....*
gi 4502443      359 AKLLNTSRNQERHLD 373
Cdd:smart00150   87 EELKELAEERRQKLE 101
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1163-1615 1.13e-06

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 54.00  E-value: 1.13e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1163 KVREAAENELRKQQRNVEdISLQKIRAES----EAKQYRRELETIVREKEAAERELERVRQLTIEAEAKRAAVEENLlnf 1238
Cdd:COG4717   50 RLEKEADELFKPQGRKPE-LNLKELKELEeelkEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLL--- 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1239 rnQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKekqkielE 1318
Cdd:COG4717  126 --QLLPLYQELEALEAELAELPERLEELEERLEELRELEEELEELEAELAELQEELEELLEQLSLATEEELQ-------D 196

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1319 ARRKITEIQytcrenalpvcpitqatscravtglqqehdkQKAEELKQQVDELTAANRKAEQDMRELTYELNALQLEKTS 1398
Cdd:COG4717  197 LAEELEELQ-------------------------------QRLAELEEELEEAQEELEELEEELEQLENELEAAALEERL 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1399 SEEKARLL------------KDKLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLKKIK 1466
Cdd:COG4717  246 KEARLLLLiaaallallglgGSLLSLILTIAGVLFLVLGLLALLFLLLAREKASLGKEAEELQALPALEELEEEELEELL 325

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1467 RNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLnsQIHSFRDEKElerlQICQRKSDHLKEQFEKSHEQLLQNIK 1546
Cdd:COG4717  326 AALGLPPDLSPEELLELLDRIEELQELLREAEELEEEL--QLEELEQEIA----ALLAEAGVEDEEELRAALEQAEEYQE 399

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4502443  1547 AEKENNDKIQRLNEELEKSNECAEMLKQkvEELTRQNNETKLMMQRIQAESENIVLEKQTIQQRCEALK 1615
Cdd:COG4717  400 LKEELEELEEQLEELLGELEELLEALDE--EELEEELEELEEELEELEEELEELREELAELEAELEQLE 466
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 1289-1619 1.24e-06

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 53.97  E-value: 1.24e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1289 KLIKQMEKDLAFQKQVAEK--QLKEKQKIELEARRKITEIQyTCRENALPVCPITQATSCRAVTGLQQEHDKQKAEELKQ 1366
Cdd:pfam17380  282 KAVSERQQQEKFEKMEQERlrQEKEEKAREVERRRKLEEAE-KARQAEMDRQAAIYAEQERMAMERERELERIRQEERKR 360

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1367 QVDELtaanRKAEQDMR-ELTYELNALQLEKTSSEEKARllkdkldetnntlrcLKLELERKDQ-AEKGYSQQLRELGRQ 1444
Cdd:pfam17380  361 ELERI----RQEEIAMEiSRMRELERLQMERQQKNERVR---------------QELEAARKVKiLEEERQRKIQQQKVE 421

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1445 LNQTTGKAEEAMQEasDLKKIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFRDEKELERLQICQ 1524
Cdd:pfam17380  422 MEQIRAEQEEARQR--EVRRLEEERAREMERVRLEEQERQQQVERLRQQEEERKRKKLELEKEKRDRKRAEEQRRKILEK 499

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1525 rksdHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEELEKSNECAEMLKQKVEELTRQNNETKLMMQRIQAESENIVLEK 1604
Cdd:pfam17380  500 ----ELEERKQAMIEEERKRKLLEKEMEERQKAIYEEERRREAEEERRKQQEMEERRRIQEQMRKATEERSRLEAMERER 575

                          330
                   ....*....|....*
gi 4502443    1605 QTIQQRCEALKIQAD 1619
Cdd:pfam17380  576 EMMRQIVESEKARAE 590
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1435-1658 1.39e-06

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 53.23  E-value: 1.39e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1435 SQQLRELGRQLNQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFRde 1514
Cdd:COG4942   19 ADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELR-- 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1515 KELERLQicQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQR---LNEELEKSNECAEMLKQKVEELTRQNNETKLMMQ 1591
Cdd:COG4942   97 AELEAQK--EELAELLRALYRLGRQPPLALLLSPEDFLDAVRRlqyLKYLAPARREQAEELRADLAELAALRAELEAERA 174

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4502443  1592 RIQAESENIVLEKQTIQQRCEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQN 1658
Cdd:COG4942  175 ELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAE 241
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1605-1864 1.42e-06

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 54.17  E-value: 1.42e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1605 QTIQQRCEALKIQAdgFKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQKcdqqniiIQNTKKEVRNL 1684
Cdd:COG1196  216 RELKEELKELEAEL--LLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLE-------LEELELELEEA 286

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1685 NAELNASKEEKRRGEQKVQLQQAQVQELNNRLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFKQSAEEFRKKMEKLMES 1764
Cdd:COG1196  287 QAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEA 366

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1765 KVITENDISGIRLDFVSLQQENSRAQENAKLCETNIKELERQLQ-------QYREQMQQGQHMEANHYQKCQKLEDELIA 1837
Cdd:COG1196  367 LLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEallerleRLEEELEELEEALAELEEEEEEEEEALEE 446

                        250       260
                 ....*....|....*....|....*..
gi 4502443  1838 QKREVENLKQKMDQQIKEHEHQLVLLQ 1864
Cdd:COG1196  447 AAEEEAELEEEEEALLELLAELLEEAA 473
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
1149-1665 1.49e-06

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 53.89  E-value: 1.49e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1149 ELKKQKSRVEE-ELPKVREAAENELRKQQRNVEDISLQKIRAE----------SEAKQYRRELETIvrekeaaERELERV 1217
Cdd:PRK02224  191 QLKAQIEEKEEkDLHERLNGLESELAELDEEIERYEEQREQARetrdeadevlEEHEERREELETL-------EAEIEDL 263

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1218 RQLTIEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKLIKQMEKD 1297
Cdd:PRK02224  264 RETIAETEREREELAEEVRDLRERLEELEEERDDLLAEAGLDDADAEAVEARREELEDRDEELRDRLEECRVAAQAHNEE 343

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1298 lafqkqvAEKQLKEKQKIELEARRKiteiqytcRENALPVcpITQATSCRAVTGLQQEhdkqKAEELKQQVDELTAANRK 1377
Cdd:PRK02224  344 -------AESLREDADDLEERAEEL--------REEAAEL--ESELEEAREAVEDRRE----EIEELEEEIEELRERFGD 402

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1378 AEQDMRELTYELNALQLEKTSSEEKARLLKDKLDETNNTLRCLKLEL----------------------ERKDQAEKgys 1435
Cdd:PRK02224  403 APVDLGNAEDFLEELREERDELREREAELEATLRTARERVEEAEALLeagkcpecgqpvegsphvetieEDRERVEE--- 479

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1436 qqLRELGRQLNQTTGKAEEAMQEASDLKKIKRnyqlELESLnheKGKLQREVDRITRAHAVAEKNiqhlNSQIHSFRDEK 1515
Cdd:PRK02224  480 --LEAELEDLEEEVEEVEERLERAEDLVEAED----RIERL---EERREDLEELIAERRETIEEK----RERAEELRERA 546

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1516 -ELERLQICQRKS-DHLKEQFEKSHEQL------LQNIKAEKENNDKIQRLNEELEKSNECAEMLKQKVEELTRQNNETK 1587
Cdd:PRK02224  547 aELEAEAEEKREAaAEAEEEAEEAREEVaelnskLAELKERIESLERIRTLLAAIADAEDEIERLREKREALAELNDERR 626

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4502443   1588 lmmQRIQAESENIV-LEKQTIQQRCEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQ 1665
Cdd:PRK02224  627 ---ERLAEKRERKReLEAEFDEARIEEAREDKERAEEYLEQVEEKLDELREERDDLQAEIGAVENELEELEELRERREA 702
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1528-1723 1.58e-06

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 53.77  E-value: 1.58e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1528 DHLKEQFE--KSHEQLLQNIKAEKENNDKIQRLNEELEKSNECAEMLKQKVEELTRQNNETKLmmQRIQAESENIVLEKQ 1605
Cdd:COG4913  228 DALVEHFDdlERAHEALEDAREQIELLEPIRELAERYAAARERLAELEYLRAALRLWFAQRRL--ELLEAELEELRAELA 305

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1606 TIQQRCEALKIQADGFKDQLRSTNEHLHKQ-TKTEQDFQRKIKCLEEDLAKSQNLVSEFKQKCDQQNIIIQNTKKE---- 1680
Cdd:COG4913  306 RLEAELERLEARLDALREELDELEAQIRGNgGDRLEQLEREIERLERELEERERRRARLEALLAALGLPLPASAEEfaal 385

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 4502443  1681 VRNLNAELNASKEEKRRGEQKVQLQQAQVQELNNRLKKVQDEL 1723
Cdd:COG4913  386 RAEAAALLEALEEELEALEEALAEAEAALRDLRRELRELEAEI 428
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1382-1855 1.96e-06

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 53.23  E-value: 1.96e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1382 MRELTYELNALQlekTSSEEKARLLKDKLDETNNTLRCLKLELERKDQAEkgysQQLRELGRQLNQTTGKAEEAMQEASD 1461
Cdd:COG4717   48 LERLEKEADELF---KPQGRKPELNLKELKELEEELKEAEEKEEEYAELQ----EELEELEEELEELEAELEELREELEK 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1462 LKKIKRNYQL--ELESLNHEKGKLQREVDRITRAHAV---AEKNIQHLNSQIHSFRDEKELERLQICQRKSDHLkEQFEK 1536
Cdd:COG4717  121 LEKLLQLLPLyqELEALEAELAELPERLEELEERLEElreLEEELEELEAELAELQEELEELLEQLSLATEEEL-QDLAE 199

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1537 SHEQLLQnikaekenndKIQRLNEELEKsnecaemLKQKVEELTRQNNETKLMMQRIQAESEnivLEKQTIQQRCEALKI 1616
Cdd:COG4717  200 ELEELQQ----------RLAELEEELEE-------AQEELEELEEELEQLENELEAAALEER---LKEARLLLLIAAALL 259

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1617 QADGFKDQLRSTNEHLHKQTKTEQDFqrkIKCLEEDLAKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLNAELNASKEEKR 1696
Cdd:COG4717  260 ALLGLGGSLLSLILTIAGVLFLVLGL---LALLFLLLAREKASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSP 336

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1697 RGEQKVQLQQAQVQELNNRLKKVQDELHLKTIEEQMTHrkmvLFQEESGKfkqSAEEFRKKMEKLMESKVITEndisgiR 1776
Cdd:COG4717  337 EELLELLDRIEELQELLREAEELEEELQLEELEQEIAA----LLAEAGVE---DEEELRAALEQAEEYQELKE------E 403

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1777 LDFVSLQQENSRAQENAKLCETNIKELERQLQQYREQMQQGQHMEANHYQKCQKLE---------DELIAQKREVENLKQ 1847
Cdd:COG4717  404 LEELEEQLEELLGELEELLEALDEEELEEELEELEEELEELEEELEELREELAELEaeleqleedGELAELLQELEELKA 483


                 ....*...
gi 4502443  1848 KMDQQIKE 1855
Cdd:COG4717  484 ELRELAEE 491
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1462-1860 3.17e-06

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 52.76  E-value: 3.17e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1462 LKKIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFRD-EKELERLQICQRKSDHLKEQFEKSHEQ 1540
Cdd:PRK03918  167 LGEVIKEIKRRIERLEKFIKRTENIEELIKEKEKELEEVLREINEISSELPElREELEKLEKEVKELEELKEEIEELEKE 246

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1541 LLQNIKAEKENNDKIQRLNEELEKSNECAEMLKQKVEELTRQNNETKLMMqRIQAESENIVLEKQTIQQRCEALKIQADG 1620
Cdd:PRK03918  247 LESLEGSKRKLEEKIRELEERIEELKKEIEELEEKVKELKELKEKAEEYI-KLSEFYEEYLDELREIEKRLSRLEEEING 325

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1621 FKDQLR---STNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLNAELNASKEEKRR 1697
Cdd:PRK03918  326 IEERIKeleEKEERLEELKKKLKELEKRLEELEERHELYEEAKAKKEELERLKKRLTGLTPEKLEKELEELEKAKEEIEE 405

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1698 GEQKVQLQQAQVQELNNRLKKVQDELHL---------KTIEEQMTHRKMVLFQEESGKFKQSAEEFRKKMEKLMESKVIT 1768
Cdd:PRK03918  406 EISKITARIGELKKEIKELKKAIEELKKakgkcpvcgRELTEEHRKELLEEYTAELKRIEKELKEIEEKERKLRKELREL 485

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1769 ENDISGIRlDFVSLQQ--ENSRAQENaKLCETNIKELERQLQQYREQMQQGQHMEAN--HYQKCQKLEDELIAQKREVEN 1844
Cdd:PRK03918  486 EKVLKKES-ELIKLKElaEQLKELEE-KLKKYNLEELEKKAEEYEKLKEKLIKLKGEikSLKKELEKLEELKKKLAELEK 563

                         410
                  ....*....|....*.
gi 4502443   1845 LKQKMDQQIKEHEHQL 1860
Cdd:PRK03918  564 KLDELEEELAELLKEL 579
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 1399-1814 3.21e-06

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 53.13  E-value: 3.21e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1399 SEEKArlLKDKLDETNNTLRCLK-LELERKDQAEKGYSQQLRELGRQLNQTTGK----------AEEAMQEASdlKKIKR 1467
Cdd:TIGR00606  166 SEGKA--LKQKFDEIFSATRYIKaLETLRQVRQTQGQKVQEHQMELKYLKQYKEkaceirdqitSKEAQLESS--REIVK 241

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1468 NYQLELESLNHEKGKLQR------EVDRITRAHAVAEKNIQHLNSQIhsfrdekELERLQICQRKSDHLKEQFEKSHEQL 1541
Cdd:TIGR00606  242 SYENELDPLKNRLKEIEHnlskimKLDNEIKALKSRKKQMEKDNSEL-------ELKMEKVFQGTDEQLNDLYHNHQRTV 314

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1542 lqnikaeKENNDKIQRLNEELEKSNECAEMLKQKVEELTRQNNETKLMMQRIQAESENIVLEKQTIQQRCE--------- 1612
Cdd:TIGR00606  315 -------REKERELVDCQRELEKLNKERRLLNQEKTELLVEQGRLQLQADRHQEHIRARDSLIQSLATRLEldgfergpf 387

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1613 -------ALKIQADGFKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLN 1685
Cdd:TIGR00606  388 serqiknFHTLVIERQEDEAKTAAQLCADLQSKERLKQEQADEIRDEKKGLGRTIELKKEILEKKQEELKFVIKELQQLE 467

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1686 ----------------------AELNASKEEKRRGEQKVQLQQAQVQELNNRLKKVQDEL-HLKTIEEQM---THRKMVL 1739
Cdd:TIGR00606  468 gssdrileldqelrkaerelskAEKNSLTETLKKEVKSLQNEKADLDRKLRKLDQEMEQLnHHTTTRTQMemlTKDKMDK 547

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1740 FQEESGKFKQSAEEF---------RKKMEKLMESKvitENDISGIRLDFVSLQQENSRAQENAKLCETNIKELERQLQQY 1810
Cdd:TIGR00606  548 DEQIRKIKSRHSDELtsllgyfpnKKQLEDWLHSK---SKEINQTRDRLAKLNKELASLEQNKNHINNELESKEEQLSSY 624


                   ....
gi 4502443    1811 REQM 1814
Cdd:TIGR00606  625 EDKL 628
HCR pfam07111
Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha ...
 1359-1852 3.35e-06

Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha helical coiled-coil rod HCR proteins. The function of HCR is unknown but it has been implicated in psoriasis in humans and is thought to affect keratinocyte proliferation.


Pssm-ID: 284517 [Multi-domain]  Cd Length: 749  Bit Score: 52.83  E-value: 3.35e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1359 QKAEELKQQVDELtaanRKAEQDMReltyelnalQLEKTSSEEKARLlkdkldetnnTLRCLKLE-LERKDQAEKGYSQQ 1437
Cdd:pfam07111   63 QQAELISRQLQEL----RRLEEEVR---------LLRETSLQQKMRL----------EAQAMELDaLAVAEKAGQAEAEG 119

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1438 LRELGRQLNQTTGKAEEAMQEasDLKKIKRNYQLELESLNHEKgklQREVDRITRAHAVAEKNIQHLNSqihsfRDEKEL 1517
Cdd:pfam07111  120 LRAALAGAEMVRKNLEEGSQR--ELEEIQRLHQEQLSSLTQAH---EEALSSLTSKAEGLEKSLNSLET-----KRAGEA 189

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1518 ERLQICQRKSDHLKEQFEKSHEQL------LQNIK--AEKENNDKIQRLNEELEKsNECAEMLKQKVEELTRQNNETKLM 1589
Cdd:pfam07111  190 KQLAEAQKEAELLRKQLSKTQEELeaqvtlVESLRkyVGEQVPPEVHSQTWELER-QELLDTMQHLQEDRADLQATVELL 268

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1590 MQRIQAESENIVLEKQTIQQRCEALKIQADGFKDQLRSTNEH-------LHKQTKTeQDFQRK--IKCLEEDLAKSQNLV 1660
Cdd:pfam07111  269 QVRVQSLTHMLALQEEELTRKIQPSDSLEPEFPKKCRSLLNRwrekvfaLMVQLKA-QDLEHRdsVKQLRGQVAELQEQV 347

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1661 SEFKQKCDQQNIIIQNTKKEV-------RNLNAELNASKEEKRRGEQKVQLQQAQVQELNNRLKKVQDELH--------- 1724
Cdd:pfam07111  348 TSQSQEQAILQRALQDKAAEVevermsaKGLQMELSRAQEARRRQQQQTASAEEQLKFVVNAMSSTQIWLEttmtrveqa 427

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1725 -----------------LKTIEEQMThRKMVLFQ--EESGKFKQSAEEFRKKMEKLMESKVITENDISG-IRLDFVSLQQ 1784
Cdd:pfam07111  428 varipslsnrlsyavrkVHTIKGLMA-RKVALAQlrQESCPPPPPAPPVDADLSLELEQLREERNRLDAeLQLSAHLIQQ 506

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4502443    1785 ENSRAQENAKLCETNIKELERQLQQyreQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQKMDQQ 1852
Cdd:pfam07111  507 EVGRAREQGEAERQQLSEVAQQLEQ---ELQRAQESLASVGQQLEVARQGQQESTEEAASLRQELTQQ 571
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 1363-1722 3.54e-06

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 52.20  E-value: 3.54e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1363 ELKQQVDELTAANRKAEQDMRELTYELNALQLEKTS-SEEKARLLKDKLDetnNTLRCLKLElerkdQAEKGYSQQLREL 1441
Cdd:pfam07888   77 ELESRVAELKEELRQSREKHEELEEKYKELSASSEElSEEKDALLAQRAA---HEARIRELE-----EDIKTLTQRVLER 148

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1442 GRQLNQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFRDekeleRLQ 1521
Cdd:pfam07888  149 ETELERMKERAKKAGAQRKEEEAERKQLQAKLQQTEEELRSLSKEFQELRNSLAQRDTQVLQLQDTITTLTQ-----KLT 223

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1522 ICQRKsdhlkeqfEKSHEQLLQNIKAekenndkiqrLNEELEKSNECAEMLKQKVEELTRQNNET--KLMMQRIQAESEN 1599
Cdd:pfam07888  224 TAHRK--------EAENEALLEELRS----------LQERLNASERKVEGLGEELSSMAAQRDRTqaELHQARLQAAQLT 285

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1600 IVLEKQTIQQRCEalKIQADGFKDQLRSTNEHLH-KQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQKCDQQNIIIQNTK 1678
Cdd:pfam07888  286 LQLADASLALREG--RARWAQERETLQQSAEADKdRIEKLSAELQRLEERLQEERMEREKLEVELGREKDCNRVQLSESR 363

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....
gi 4502443    1679 KEVRNLNAELNASKEEKRRGEQKVQLQQAQVQELNNRLKKVQDE 1722
Cdd:pfam07888  364 RELQELKASLRVAQKEKEQLQAEKQELLEYIRQLEQRLETVADA 407
PTZ00121 PTZ00121
MAEBL; Provisional
 981-1325 4.01e-06

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 52.84  E-value: 4.01e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    981 QQVETTQRKIQE-NQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEqysATVKDYELQTMTYRAMVDSQQKSPVK 1059
Cdd:PTZ00121 1457 KKAEEAKKKAEEaKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAE---AKKKADEAKKAEEAKKADEAKKAEEA 1533

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1060 RRRMQSSADLIIQEFMDLR----TRYTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEHGAYSDLLQRQKATVLENSK 1135
Cdd:PTZ00121 1534 KKADEAKKAEEKKKADELKkaeeLKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAK 1613

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1136 LtgkiSELERMVAELKKQKSRVEEELPKVREAAENELRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAERELE 1215
Cdd:PTZ00121 1614 K----AEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKK 1689

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1216 RVRQLTIEAEAKRAAveENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKLIKQME 1295
Cdd:PTZ00121 1690 AAEALKKEAEEAKKA--EELKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDKKKAEEAKKDEEEKKKIAHLKKEEE 1767

                         330       340       350
                  ....*....|....*....|....*....|
gi 4502443   1296 KDLAFQKQVAEKQLKEKQKIELEARRKITE 1325
Cdd:PTZ00121 1768 KKAEEIRKEKEAVIEEELDEEDEKRRMEVD 1797
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 627-1772 5.31e-06

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 52.36  E-value: 5.31e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443     627 NRIEQQYQNVLTlwHESHINMKSVVSWHYLINEIDRIRASNVASIKTmlpgehqQVLSNLQSRFEDFLEDSQESQVFSGS 706
Cdd:TIGR01612 1029 NDIEQKIEDANK--NIPNIEIAIHTSIYNIIDEIEKEIGKNIELLNK-------EILEEAEINITNFNEIKEKLKHYNFD 1099

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443     707 DITqleKEVNVckQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIrtplerDDLhESVFRITEQEKL 786
Cdd:TIGR01612 1100 DFG---KEENI--KYADEINKIKDDIKNLDQKIDHHIKALEEIKKKSENYIDEIKAQI------NDL-EDVADKAISNDD 1167

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443     787 KKELERLKDDLGTITNKCEEFFSqaaasssvptlrsELNVVLQNMNQVySMSSTYIDKLKTVNLvlkntQAAEALVKLYE 866
Cdd:TIGR01612 1168 PEEIEKKIENIVTKIDKKKNIYD-------------EIKKLLNEIAEI-EKDKTSLEEVKGINL-----SYGKNLGKLFL 1228

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443     867 TKLCEEeaviadKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEM--FKTYKERDLDFDWHKEKADQLVER 944
Cdd:TIGR01612 1229 EKIDEE------KKKSEHMIKAMEAYIEDLDEIKEKSPEIENEMGIEMDIKAEMetFNISHDDDKDHHIISKKHDENISD 1302

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443     945 WQNVHVQI---DNRLRDLEGIGKSLKYY------------------RDTYHPL-----DDWIQQVETTQRKIQenqpENS 998
Cdd:TIGR01612 1303 IREKSLKIiedFSEESDINDIKKELQKNlldaqkhnsdinlylneiANIYNILklnkiKKIIDEVKEYTKEIE----ENN 1378

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443     999 KTLATQLNQQKMLVSEIEmKQSKMDECQKYAEqysATVKDYELQtmtyramvDSQQKSPVKRRRMQSSADLIIQEFMDLR 1078
Cdd:TIGR01612 1379 KNIKDELDKSEKLIKKIK-DDINLEECKSKIE---STLDDKDID--------ECIKKIKELKNHILSEESNIDTYFKNAD 1446

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1079 tRYTALVTLMTQYIKFAGDSLKRLeeEEIKRCKETSEHG-------AYSDLLQRQKATVLENSKLTGKISELermvaeLK 1151
Cdd:TIGR01612 1447 -ENNENVLLLFKNIEMADNKSQHI--LKIKKDNATNDHDfninelkEHIDKSKGCKDEADKNAKAIEKNKEL------FE 1517

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1152 KQKSRVEEELPKVREAAENELRKQQRNVEDISLQKIRaesEAKQyrreleTIVREKEAAERELERVR--QLTIEAEA--- 1226
Cdd:TIGR01612 1518 QYKKDVTELLNKYSALAIKNKFAKTKKDSEIIIKEIK---DAHK------KFILEAEKSEQKIKEIKkeKFRIEDDAakn 1588

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1227 ---KRAA--VEENLLNFRNQLEENTFTRRTLEDHLK-----RKDLSLNDLEQQKNKLmEELRRKRDNEEELLKLIKQMEK 1296
Cdd:TIGR01612 1589 dksNKAAidIQLSLENFENKFLKISDIKKKINDCLKetesiEKKISSFSIDSQDTEL-KENGDNLNSLQEFLESLKDQKK 1667

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1297 DLAFQKQVAEKQLKEKQKIELEA--RRKITEIQytcrenalpvcpITQATSCRAVTglqqehDKQKAEELKQQVdeltaa 1374
Cdd:TIGR01612 1668 NIEDKKKELDELDSEIEKIEIDVdqHKKNYEIG------------IIEKIKEIAIA------NKEEIESIKELI------ 1723

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1375 nrkaEQDMRELTYELNALQLEKTSSEEkarllkdKLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLNQTTGKAEE 1454
Cdd:TIGR01612 1724 ----EPTIENLISSFNTNDLEGIDPNE-------KLEEYNTEIGDIYEEFIELYNIIAGCLETVSKEPITYDEIKNTRIN 1792

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1455 AMQEASDLKKIKRNYQLELES---------LNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFR---DEKELerLQI 1522
Cdd:TIGR01612 1793 AQNEFLKIIEIEKKSKSYLDDieakefdriINHFKKKLDHVNDKFTKEYSKINEGFDDISKSIENVKnstDENLL--FDI 1870

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1523 CQRKSDHLKEQFEKSH-------EQLLQNI-KAEKENNDKIQrlneelekSNECAEMLKQ-KVEELTRQNNETKLMMQRI 1593
Cdd:TIGR01612 1871 LNKTKDAYAGIIGKKYysykdeaEKIFINIsKLANSINIQIQ--------NNSGIDLFDNiNIAILSSLDSEKEDTLKFI 1942

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1594 ---QAESENIVLEKQTIQQRCEALKIQADGFKDQ-----LRSTNEHLH---KQTKTEQDFQRKIKCLEEDLAKSQNLV-- 1660
Cdd:TIGR01612 1943 pspEKEPEIYTKIRDSYDTLLDIFKKSQDLHKKEqdtlnIIFENQQLYekiQASNELKDTLSDLKYKKEKILNDVKLLlh 2022

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1661 --SEFKQ-KCDQQN--IIIQNTKKEvrNLNAELNASKEEKRRGEQKVQLqQAQVQELNNRLKKVQDELHLKTIEEQMTHR 1735
Cdd:TIGR01612 2023 kfDELNKlSCDSQNydTILELSKQD--KIKEKIDNYEKEKEKFGIDFDV-KAMEEKFDNDIKDIEKFENNYKHSEKDNHD 2099

                         1210      1220      1230      1240
                   ....*....|....*....|....*....|....*....|...
gi 4502443    1736 kmvlFQEESGKFKQSAEEFRKKME------KLMESKVITENDI 1772
Cdd:TIGR01612 2100 ----FSEEKDNIIQSKKKLKELTEafnteiKIIEDKIIEKNDL 2138
PLEC smart00250
Plectin repeat;
2553-2586 5.80e-06

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 45.17  E-value: 5.80e-06
                            10        20        30
                    ....*....|....*....|....*....|....
gi 4502443     2553 IRCLEFQYLTGGLIEPQVHSRLSIEEALQVGIID 2586
Cdd:smart00250    1 QRLLEAQSAIGGIIDPETGQKLSVEEALRRGLID 34
PRK04778 PRK04778
septation ring formation regulator EzrA; Provisional
 1139-1591 7.69e-06

septation ring formation regulator EzrA; Provisional


Pssm-ID: 179877 [Multi-domain]  Cd Length: 569  Bit Score: 51.38  E-value: 7.69e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1139 KISELERMVAELKKQKsrVEEELPKVREA-----AENELRKQQRNVEDISLQKI--------RAESEAKQYR-----REL 1200
Cdd:PRK04778   30 RIDELEERKQELENLP--VNDELEKVKKLnltgqSEEKFEEWRQKWDEIVTNSLpdieeqlfEAEELNDKFRfrkakHEI 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1201 ETIVREKEAAERELERVR----QLTIEAEAKRAAVEENLLNF---RNQLEENTFTRRTLEDHLKRKdlsLNDLEQQKNKl 1273
Cdd:PRK04778  108 NEIESLLDLIEEDIEQILeelqELLESEEKNREEVEQLKDLYrelRKSLLANRFSFGPALDELEKQ---LENLEEEFSQ- 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1274 MEELRRKRDNE---EELLKLIKQMEkdlAFQKQVAE-KQLKEKQKIELEARrkITEIQYTCRE-----NALPVCPITQAt 1344
Cdd:PRK04778  184 FVELTESGDYVearEILDQLEEELA---ALEQIMEEiPELLKELQTELPDQ--LQELKAGYRElveegYHLDHLDIEKE- 257

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1345 scraVTGLQQEHDKQKAEELKQQVDELTAANRKAEQDMRELtYELnaLQLE---KTSSEEKARLLKDKLDETNNTLRCLK 1421
Cdd:PRK04778  258 ----IQDLKEQIDENLALLEELDLDEAEEKNEEIQERIDQL-YDI--LEREvkaRKYVEKNSDTLPDFLEHAKEQNKELK 330

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1422 LELERKDQA----------EKGYSQQLRELGRQLNQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRIT 1491
Cdd:PRK04778  331 EEIDRVKQSytlneselesVRQLEKQLESLEKQYDEITERIAEQEIAYSELQEELEEILKQLEEIEKEQEKLSEMLQGLR 410

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1492 RAHAVAEKNIQHLNSQIHSFRdeKELERLQICQRKSDHLKEQFEKSHE--QLLQNIKAEKENNDKIQRLneeLEKSNECA 1569
Cdd:PRK04778  411 KDELEAREKLERYRNKLHEIK--RYLEKSNLPGLPEDYLEMFFEVSDEieALAEELEEKPINMEAVNRL---LEEATEDV 485

                         490       500
                  ....*....|....*....|..
gi 4502443   1570 EMLKQKVEELTRQNNETKLMMQ 1591
Cdd:PRK04778  486 ETLEEETEELVENATLTEQLIQ 507
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 1134-1465 7.94e-06

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 51.56  E-value: 7.94e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1134 SKLTGKISELERMVAELKKQKSRVEEELPKVREAAENELRKQQRNVEDISL---------QKIR-AESEAKQYRRELETI 1203
Cdd:TIGR04523  338 SQLNEQISQLKKELTNSESENSEKQRELEEKQNEIEKLKKENQSYKQEIKNlesqindleSKIQnQEKLNQQKDEQIKKL 417

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1204 VREKEAAERELERVRQLTIEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDN 1283
Cdd:TIGR04523  418 QQEKELLEKEIERLKETIIKNNSEIKDLTNQDSVKELIIKNLDNTRESLETQLKVLSRSINKIKQNLEQKQKELKSKEKE 497

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1284 EEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCREnalpvcpITQATSCRAVTGLQQEHDK--QKA 1361
Cdd:TIGR04523  498 LKKLNEEKKELEEKVKDLTKKISSLKEKIEKLESEKKEKESKISDLEDE-------LNKDDFELKKENLEKEIDEknKEI 570

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1362 EELKQQVDELTAANRKAEQDMRELTYELNALQLEKTSSEEKARLLKDKLDETNNTLRCLKLELERKDQAEKGYSQQLREL 1441
Cdd:TIGR04523  571 EELKQTQKSLKKKQEEKQELIDQKEKEKKDLIKEIEEKEKKISSLEKELEKAKKENEKLSSIIKNIKSKKNKLKQEVKQI 650

                          330       340
                   ....*....|....*....|....
gi 4502443    1442 GRQLNQTTGKAEEAMQEASDLKKI 1465
Cdd:TIGR04523  651 KETIKEIRNKWPEIIKKIKESKTK 674
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
 1311-1859 9.86e-06

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 51.28  E-value: 9.86e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1311 EKQKIELEARRKITEIQYTCRENAlpvcpitqatscravTGLQQEHDKQKaeELKQQVDELTAANRKAEQDMREltyELN 1390
Cdd:pfam05557   17 EKKQMELEHKRARIELEKKASALK---------------RQLDRESDRNQ--ELQKRIRLLEKREAEAEEALRE---QAE 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1391 ALQLEKTSSEEKARLLKDK---LDETNNTLRCLKlelerkdqaekgysqqlrelgrqlnqttgkaeeamQEASDLKKIKR 1467
Cdd:pfam05557   77 LNRLKKKYLEALNKKLNEKesqLADAREVISCLK-----------------------------------NELSELRRQIQ 121

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1468 NYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFRDE----KELERlQICQRKSDhlKEQFEKSHEQLLQ 1543
Cdd:pfam05557  122 RAELELQSTNSELEELQERLDLLKAKASEAEQLRQNLEKQQSSLAEAeqriKELEF-EIQSQEQD--SEIVKNSKSELAR 198

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1544 NIKAEKEnndkIQRL---NEELEKSNECAEMLKQKVEELtrqnnETKL-MMQRIQAESENIVLEKQTIQQRCEALKiqad 1619
Cdd:pfam05557  199 IPELEKE----LERLrehNKHLNENIENKLLLKEEVEDL-----KRKLeREEKYREEAATLELEKEKLEQELQSWV---- 265

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1620 gfkdqlrstnehlhkqtKTEQDfqrkiKCLeeDLAKSQNLVSEFKQkCDQQNIiiqNTKKEVRNLNAELNASKEEKRRGE 1699
Cdd:pfam05557  266 -----------------KLAQD-----TGL--NLRSPEDLSRRIEQ-LQQREI---VLKEENSSLTSSARQLEKARRELE 317

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1700 QKVQLQQAQVQELNNRLKkvqdelHLKTIEEQMTHRKMVLFQEESGkFKQSAEEFRKKM------EKLMESKVITENDIS 1773
Cdd:pfam05557  318 QELAQYLKKIEDLNKKLK------RHKALVRRLQRRVLLLTKERDG-YRAILESYDKELtmsnysPQLLERIEEAEDMTQ 390

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1774 GIRLDFVSLQQENSRAQENAKLCETNIKELERQLQQYREQMQQG-QHMEANHYQKCQKLEDELIAQKREVENLKQKMDQQ 1852
Cdd:pfam05557  391 KMQAHNEEMEAQLSVAEEELGGYKQQAQTLERELQALRQQESLAdPSYSKEEVDSLRRKLETLELERQRLREQKNELEME 470


                   ....*..
gi 4502443    1853 IKEHEHQ 1859
Cdd:pfam05557  471 LERRCLQ 477
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 1393-1736 1.11e-05

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 50.89  E-value: 1.11e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1393 QLEKTSSEEKARLLKDKLDETNntlrclklELERKDQAEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLKKIKRNYQle 1472
Cdd:pfam17380  289 QQEKFEKMEQERLRQEKEEKAR--------EVERRRKLEEAEKARQAEMDRQAAIYAEQERMAMERERELERIRQEER-- 358

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1473 leslnhekgklQREVDRITRahavaekniQHLNSQIHSFRdekELERLQI-CQRKSDHLKEQFEKSHEQLLQ-------- 1543
Cdd:pfam17380  359 -----------KRELERIRQ---------EEIAMEISRMR---ELERLQMeRQQKNERVRQELEAARKVKILeeerqrki 415

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1544 --------NIKAEKEN--NDKIQRLNEELEKsnecaEMLKQKVEELTRQNNETKLMMQRIQAESENIVLEKQTiQQRCEA 1613
Cdd:pfam17380  416 qqqkvemeQIRAEQEEarQREVRRLEEERAR-----EMERVRLEEQERQQQVERLRQQEEERKRKKLELEKEK-RDRKRA 489

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1614 LKIQADGFKDQLRStnehlHKQTKTEQDFQRKIkcLEEDLAKSQNLVSEFKQKcdqqniiiqNTKKEVRNLNAELnaskE 1693
Cdd:pfam17380  490 EEQRRKILEKELEE-----RKQAMIEEERKRKL--LEKEMEERQKAIYEEERR---------REAEEERRKQQEM----E 549

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....
gi 4502443    1694 EKRRgeqkVQLQQAQVQELNNRLKKVQDELH-LKTIEEQMTHRK 1736
Cdd:pfam17380  550 ERRR----IQEQMRKATEERSRLEAMEREREmMRQIVESEKARA 589
PRK12704 PRK12704
phosphodiesterase; Provisional
 1184-1326 1.17e-05

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 50.55  E-value: 1.17e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1184 LQKIRAESEAKQYRRELETIVrekEAAERELERVRQLtIEAEAKraaveENLLNFRNQLEENTFTRRtleDHLKRKDLSL 1263
Cdd:PRK12704   24 VRKKIAEAKIKEAEEEAKRIL---EEAKKEAEAIKKE-ALLEAK-----EEIHKLRNEFEKELRERR---NELQKLEKRL 91

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4502443   1264 NDLEQQKNKLMEELRRKrdnEEELLKLikqmEKDLAFQKQVAEKQLKEKQKIELEARRKITEI 1326
Cdd:PRK12704   92 LQKEENLDRKLELLEKR---EEELEKK----EKELEQKQQELEKKEEELEELIEEQLQELERI 147
PLN02939 PLN02939
transferase, transferring glycosyl groups
 1264-1564 1.78e-05

transferase, transferring glycosyl groups


Pssm-ID: 215507 [Multi-domain]  Cd Length: 977  Bit Score: 50.29  E-value: 1.78e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1264 NDLEQQKNKLMEElRRKRDNEEELLKLIKQMEKDLAFQKQV-------AEKQLKEKQKIElearRKITEIQYTCREnalp 1336
Cdd:PLN02939  111 IDNEQQTNSKDGE-QLSDFQLEDLVGMIQNAEKNILLLNQArlqaledLEKILTEKEALQ----GKINILEMRLSE---- 181

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1337 vcpitqaTSCRAVTGLQQEHDKQKAEE-LKQQVDELTAANRKAEQDMRELTYELNALQLEKTSSEEKARLLKDKLDETNN 1415
Cdd:PLN02939  182 -------TDARIKLAAQEKIHVEILEEqLEKLRNELLIRGATEGLCVHSLSKELDVLKEENMLLKDDIQFLKAELIEVAE 254

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1416 T-LRCLKLELERKdqaekGYSQQLRELGRQLNQttgkAEEAMQEASDLKkikrnYQLELESLNHEKGKLQREVDRITRAH 1494
Cdd:PLN02939  255 TeERVFKLEKERS-----LLDASLRELESKFIV----AQEDVSKLSPLQ-----YDCWWEKVENLQDLLDRATNQVEKAA 320

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1495 AVAEKNiQHLNSQIHSFRDEKE--------LERLQICQRKSDHLKEQFEKSHEQLLQNIK----AEKENNDKIQRLNEEL 1562
Cdd:PLN02939  321 LVLDQN-QDLRDKVDKLEASLKeanvskfsSYKVELLQQKLKLLEERLQASDHEIHSYIQlyqeSIKEFQDTLSKLKEES 399


                  ..
gi 4502443   1563 EK 1564
Cdd:PLN02939  400 KK 401
mukB PRK04863
chromosome partition protein MukB;
1436-1736 1.81e-05

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 50.73  E-value: 1.81e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1436 QQLRELGRQLNQttgKAEEAMQEASDLKKIKRNYQ-------------------LELESLNHEKGKLQREVDRIT----- 1491
Cdd:PRK04863  786 KRIEQLRAEREE---LAERYATLSFDVQKLQRLHQafsrfigshlavafeadpeAELRQLNRRRVELERALADHEsqeqq 862

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1492 -RAHAVAEKN----IQHLNSQIHSFRDEKELERLQICQRKSDHLKE--QFEKSH-------EQLLQNIKAEKENNDKIQR 1557
Cdd:PRK04863  863 qRSQLEQAKEglsaLNRLLPRLNLLADETLADRVEEIREQLDEAEEakRFVQQHgnalaqlEPIVSVLQSDPEQFEQLKQ 942

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1558 LNEELEKSNEcaeMLKQKVEELTRqnnetklMMQRIQ----AESENIVLEKQ----TIQQRCEALKIQADGFKDQLRSTN 1629
Cdd:PRK04863  943 DYQQAQQTQR---DAKQQAFALTE-------VVQRRAhfsyEDAAEMLAKNSdlneKLRQRLEQAEQERTRAREQLRQAQ 1012

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1630 EHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQKCDQQNIIIQNTKKEvrNLNAELNASKEEKRRGEQKVQLQQAQV 1709
Cdd:PRK04863 1013 AQLAQYNQVLASLKSSYDAKRQMLQELKQELQDLGVPADSGAEERARARRD--ELHARLSANRSRRNQLEKQLTFCEAEM 1090

                         330       340
                  ....*....|....*....|....*..
gi 4502443   1710 QELNNRLKKVQDELHlkTIEEQMTHRK 1736
Cdd:PRK04863 1091 DNLTKKLRKLERDYH--EMREQVVNAK 1115
Tht1 pfam04163
Tht1-like nuclear fusion protein;
1599-1875 1.96e-05

Tht1-like nuclear fusion protein;


Pssm-ID: 282073  Cd Length: 595  Bit Score: 50.21  E-value: 1.96e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1599 NIVLEKQTIQQRCEALKIQADGFKDQLRSTNEHLHKQTktEQDFQRkikcLEEDLAKS-QNLVSEFKQKCDQQNIIIQNT 1677
Cdd:pfam04163  156 LLEFEKELIIELFLNITELQDQFGDDLDMKILHLMFQM--EQDFEN----FLDDLAQMfDKFDGEFNNATESNRIIIEND 229

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1678 KKEVRNLNAELNASKEEKRRGEQKVQLQQAQVQELNNRLKKVQDELhlktieeqmtHRKMVLFQEESGKFKQSAeefrkk 1757
Cdd:pfam04163  230 FKDFNFKVNDEIMGLVELENHEQEGMVLEKEIIEKIKQLKNEIDDI----------HHFFADFADELAGYKNDI------ 293

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1758 MEKLMESKVITENDIsgirldfvSLQQENSRAQENAKLCETNIKELERQLQQYREQMQQGQHMEANhyQKCQKLEDELIA 1837
Cdd:pfam04163  294 IEKINDLKDDSENAI--------ALSAIGKYTSEFSAFMEKNIKDLIEMSEDSLKESVQRNIDFVN--SGFQELEDFSIG 363

                          250       260       270
                   ....*....|....*....|....*....|....*....
gi 4502443    1838 QKREVENLKQKM-DQQIKEHEHqlvLLQCEIQKKSTAKD 1875
Cdd:pfam04163  364 LKEELGGLKKDLsEQQNLEAEE---ILQWKSDFLNILHD 399
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
 1432-1874 2.18e-05

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 50.21  E-value: 2.18e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1432 KGYSQQLRELGRQLNQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSF 1511
Cdd:pfam10174  170 KGLPKKSGEEDWERTRRIAEAEMQLGHLEVLLDQKEKENIHLREELHRRNQLQPDPAKTKALQTVIEMKDTKISSLERNI 249

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1512 RD-EKELERLQ-----ICQRKSDHLKeQFE--KSHEQLLQNikaekenndKIQRLNEELEKSNECAEMLKQKVEELTRQN 1583
Cdd:pfam10174  250 RDlEDEVQMLKtngllHTEDREEEIK-QMEvyKSHSKFMKN---------KIDQLKQELSKKESELLALQTKLETLTNQN 319

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1584 NETKlmmQRIQAESENIVLEkqtiQQRCEALKIQADGFKDQLRSTNEHLHKQTKTEQD---------------------- 1641
Cdd:pfam10174  320 SDCK---QHIEVLKESLTAK----EQRAAILQTEVDALRLRLEEKESFLNKKTKQLQDlteekstlageirdlkdmldvk 392

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1642 ------FQRKIKCLEEDLAKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLNAELnASKEE--KRRGEQKVQLQQAQVQELN 1713
Cdd:pfam10174  393 erkinvLQKKIENLQEQLRDKDKQLAGLKERVKSLQTDSSNTDTALTTLEEAL-SEKERiiERLKEQREREDRERLEELE 471

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1714 NRLKKvqdelhLKTIEEQMTHRKMVLFQEESG--KFKQSAEEFRKKMEKLMESKVITENDISGIRLDFVSLQQENSRAQE 1791
Cdd:pfam10174  472 SLKKE------NKDLKEKVSALQPELTEKESSliDLKEHASSLASSGLKKDSKLKSLEIAVEQKKEECSKLENQLKKAHN 545

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1792 NAKLCETN------IKELERQLQQYREqmqqgqhmEANhyqKCQKLEDELIAQKREVENLKQKMDQQIKEHEhQLVLLQC 1865
Cdd:pfam10174  546 AEEAVRTNpeindrIRLLEQEVARYKE--------ESG---KAQAEVERLLGILREVENEKNDKDKKIAELE-SLTLRQM 613


                   ....*....
gi 4502443    1866 EIQKKSTAK 1874
Cdd:pfam10174  614 KEQNKKVAN 622
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1514-1723 2.33e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 49.38  E-value: 2.33e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1514 EKELERLQICQRKSDHLKEQFEKSHEQLLQNIKaekENNDKIQRLNEELEKSNECAEMLKQKVEELTRQNNETKLMMQRI 1593
Cdd:COG4942   26 EAELEQLQQEIAELEKELAALKKEEKALLKQLA---ALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQ 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1594 QAESENIVLEKQTIQQRCE-ALKIQADGFKDQLRST------NEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQK 1666
Cdd:COG4942  103 KEELAELLRALYRLGRQPPlALLLSPEDFLDAVRRLqylkylAPARREQAEELRADLAELAALRAELEAERAELEALLAE 182

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 4502443  1667 CDQQNIIIQNTKKEVRNLNAELNASKEEKRrgeQKVQLQQAQVQELNNRLKKVQDEL 1723
Cdd:COG4942  183 LEEERAALEALKAERQKLLARLEKELAELA---AELAELQQEAEELEALIARLEAEA 236
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 1519-1876 2.45e-05

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 49.51  E-value: 2.45e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1519 RLQICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEELEKS----NECAEMLKQKVEELTRQNNETKLMMQRIQ 1594
Cdd:pfam07888   35 RLEECLQERAELLQAQEAANRQREKEKERYKRDREQWERQRRELESRvaelKEELRQSREKHEELEEKYKELSASSEELS 114

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1595 AESENIVLEKQTIQQRCEALK--IQADGFKDQLRSTNEHLHKQTKTEQDFQRKikcleEDLAKSQNLVSEFKQkcdqqni 1672
Cdd:pfam07888  115 EEKDALLAQRAAHEARIRELEedIKTLTQRVLERETELERMKERAKKAGAQRK-----EEEAERKQLQAKLQQ------- 182

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1673 iiqnTKKEVRNLNAELNASKEEKRRGEQKVQLQQAQVQELNNRLkkvqDELHLKTIEEQMTHRKMVLFQEESGKFKQSAE 1752
Cdd:pfam07888  183 ----TEEELRSLSKEFQELRNSLAQRDTQVLQLQDTITTLTQKL----TTAHRKEAENEALLEELRSLQERLNASERKVE 254

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1753 EFRKKMEKLMESKVITENDISGIRLDfvslqqensRAQENAKLCETNI--KELERQLQQYREQMQQGqhMEANHyQKCQK 1830
Cdd:pfam07888  255 GLGEELSSMAAQRDRTQAELHQARLQ---------AAQLTLQLADASLalREGRARWAQERETLQQS--AEADK-DRIEK 322

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*.
gi 4502443    1831 LEDELiaqkrevenlkQKMDQQIKEHEHQLVLLQCEIQKKstaKDC 1876
Cdd:pfam07888  323 LSAEL-----------QRLEERLQEERMEREKLEVELGRE---KDC 354
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 1113-1846 2.54e-05

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 49.95  E-value: 2.54e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1113 TSEHGAYSDLLQRqkatVLENSKLTGKIselERMVAELKKQKSRVEEELPKVREAAENELRKQQRnvedislqKIRAESE 1192
Cdd:COG3096  326 EQDYQAASDHLNL----VQTALRQQEKI---ERYQEDLEELTERLEEQEEVVEEAAEQLAEAEAR--------LEAAEEE 390

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1193 AKQ-------YRRELETIVREKEA---AERELERVRQLTIEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKDLS 1262
Cdd:COG3096  391 VDSlksqladYQQALDVQQTRAIQyqqAVQALEKARALCGLPDLTPENAEDYLAAFRAKEQQATEEVLELEQKLSVADAA 470

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1263 LNDLE-------------------QQKNKLMEELRRKR---DNEEELLKLIKQMEKDLAFQKQvAEKQLKE---KQKIEL 1317
Cdd:COG3096  471 RRQFEkayelvckiageversqawQTARELLRRYRSQQalaQRLQQLRAQLAELEQRLRQQQN-AERLLEEfcqRIGQQL 549

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1318 EARRKITEIQYTcRENALPVCPITQATSCRAVTGLQQEHD--KQKAEELKQQVDELTAANRKAEQdMRELTYE------- 1388
Cdd:COG3096  550 DAAEELEELLAE-LEAQLEELEEQAAEAVEQRSELRQQLEqlRARIKELAARAPAWLAAQDALER-LREQSGEaladsqe 627

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1389 -LNALQ--LEKtssEEKARLLKDKLDETNntlRCLKLELERKDQAEKGYSQQLRELGRQLN------------------- 1446
Cdd:COG3096  628 vTAAMQqlLER---EREATVERDELAARK---QALESQIERLSQPGGAEDPRLLALAERLGgvllseiyddvtledapyf 701

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1447 -------------QTTGKAEEAMQE----ASDLKKIKRNYQLELESLNH----EKGKLQREVDRITR----------AHA 1495
Cdd:COG3096  702 salygparhaivvPDLSAVKEQLAGledcPEDLYLIEGDPDSFDDSVFDaeelEDAVVVKLSDRQWRysrfpevplfGRA 781

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1496 VAEKNIQHLNS-------QIHSFR-DEKELERL--QICQRKSDHLKEQFEKSHEQLLQNIkaekenNDKIQRLNEELEKS 1565
Cdd:COG3096  782 AREKRLEELRAerdelaeQYAKASfDVQKLQRLhqAFSQFVGGHLAVAFAPDPEAELAAL------RQRRSELERELAQH 855

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1566 NECAEMLKQKVEELTRQNNetklMMQRIQAESEniVLEKQTIQQRCEALKIQADGFKDQLRSTNEHLHKQTKTEqdfqRK 1645
Cdd:COG3096  856 RAQEQQLRQQLDQLKEQLQ----LLNKLLPQAN--LLADETLADRLEELREELDAAQEAQAFIQQHGKALAQLE----PL 925

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1646 IKCLEEDLAKSQNLVSEFKQKCDQQNIIIQNTK--KEVRNLNAELNASKEEKRRGEQ-------KVQLQQAQVQ--ELNN 1714
Cdd:COG3096  926 VAVLQSDPEQFEQLQADYLQAKEQQRRLKQQIFalSEVVQRRPHFSYEDAVGLLGENsdlneklRARLEQAEEArrEARE 1005

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1715 RLKKVQDELhlktieEQMTHRKMVLFQEESGKfKQSAEEFRKKMEKLmeskvitendisGIRLDFVSLQQENSRAQE-NA 1793
Cdd:COG3096 1006 QLRQAQAQY------SQYNQVLASLKSSRDAK-QQTLQELEQELEEL------------GVQADAEAEERARIRRDElHE 1066

                        810       820       830       840       850
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 4502443  1794 KLCETN--IKELERQLQQYREQMQQGQhmeanhyQKCQKLEDELIAQKREVENLK 1846
Cdd:COG3096 1067 ELSQNRsrRSQLEKQLTRCEAEMDSLQ-------KRLRKAERDYKQEREQVVQAK 1114
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1142-1657 2.82e-05

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 49.91  E-value: 2.82e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1142 ELERMVAELKKQKSRVE--EELPKVREAAENELRKQQRnvedisLQKIRAESEAKQYRRELETIVREKEAAERELERVRQ 1219
Cdd:COG4913  236 DLERAHEALEDAREQIEllEPIRELAERYAAARERLAE------LEYLRAALRLWFAQRRLELLEAELEELRAELARLEA 309

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1220 LTIEAEAKRAAVEENLLNFRNQLEENTFTRrtledhlkrkdlsLNDLEQQKNKLMEELRRKRDNEEELLKLIKQmekdLA 1299
Cdd:COG4913  310 ELERLEARLDALREELDELEAQIRGNGGDR-------------LEQLEREIERLERELEERERRRARLEALLAA----LG 372

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1300 FQKQVAEKQLKEKQKIELEARRKITEIQYTCRENAlpvcpiTQATscRAVTGLQQEHDKQKAE--ELKQQV--------- 1368
Cdd:COG4913  373 LPLPASAEEFAALRAEAAALLEALEEELEALEEAL------AEAE--AALRDLRRELRELEAEiaSLERRKsniparlla 444

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1369 --DELTAANRKAEQDMR---ELtyelnaLQLEKTSSE-----EKA------RLL---------KDKLDETNNTLRcLKLE 1423
Cdd:COG4913  445 lrDALAEALGLDEAELPfvgEL------IEVRPEEERwrgaiERVlggfalTLLvppehyaaaLRWVNRLHLRGR-LVYE 517

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1424 LERKDQA--------EKGYSQQL------------RELGR-----------QLNQTT--------GKAEEAMQEASDLKK 1464
Cdd:COG4913  518 RVRTGLPdperprldPDSLAGKLdfkphpfrawleAELGRrfdyvcvdspeELRRHPraitragqVKGNGTRHEKDDRRR 597

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1465 IKRNYQLELEslNHEKGK-LQREVDRITRAHAVAEKNIQHLNSQIHSFRdekelERLQICQRKSDHLKEQFE-KSHEQLL 1542
Cdd:COG4913  598 IRSRYVLGFD--NRAKLAaLEAELAELEEELAEAEERLEALEAELDALQ-----ERREALQRLAEYSWDEIDvASAEREI 670

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1543 QNIKAEKE----NNDKIQRLNEELEKsnecaemLKQKVEELTRQNNETKLMMQRIQAESENIVLEKQTIQQRCEALkiqA 1618
Cdd:COG4913  671 AELEAELErldaSSDDLAALEEQLEE-------LEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAA---E 740

                        570       580       590
                 ....*....|....*....|....*....|....*....
gi 4502443  1619 DGFKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQ 1657
Cdd:COG4913  741 DLARLELRALLEERFAAALGDAVERELRENLEERIDALR 779
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 1169-1326 3.45e-05

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 47.61  E-value: 3.45e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1169 ENELRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLTIEAEAKRAAVEENLLNFRNQLEENTFT 1248
Cdd:COG1579   16 DSELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLGNVRNNKEYEALQ 95

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4502443  1249 RRtlEDHLKRKdlsLNDLEQQKNKLMEELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEI 1326
Cdd:COG1579   96 KE--IESLKRR---ISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAELEELEAEREEL 168
MARTX_Nterm NF012221
MARTX multifunctional-autoprocessing repeats-in-toxin holotoxin N-terminal region; This model ...
 1524-1710 3.46e-05

MARTX multifunctional-autoprocessing repeats-in-toxin holotoxin N-terminal region; This model describes the N-terminal 1900 amino acids of MARTX family multifunctional-autoprocessing repeats-in-toxin holotoxins, which contain both repeat regions that facilitate their entry into eukaryotic target cells, and multiple effector domains.


Pssm-ID: 467957 [Multi-domain]  Cd Length: 1848  Bit Score: 49.83  E-value: 3.46e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1524 QRKSDHLKEQFEKSheQLLQNIKAEKENNDK-IQRLneELEKSNECAEMLK-QKVEELTRQNN-ETKLMMQR--IQAESE 1598
Cdd:NF012221 1541 SQQADAVSKHAKQD--DAAQNALADKERAEAdRQRL--EQEKQQQLAAISGsQSQLESTDQNAlETNGQAQRdaILEESR 1616

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1599 NIVLEKQTIQQRCEALKIQ---------------ADGFKD----QLRSTNEHLHKQ-TKTEQDFQRKIKCLEEDLAKSQN 1658
Cdd:NF012221 1617 AVTKELTTLAQGLDALDSQatyagesgdqwrnpfAGGLLDrvqeQLDDAKKISGKQlADAKQRHVDNQQKVKDAVAKSEA 1696

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1659 LV--SEFKQKCDQQNIIIQNTKKEVRNLNAELN-------------ASKEEKRRGEQKV---QLQQAQVQ 1710
Cdd:NF012221 1697 GVaqGEQNQANAEQDIDDAKADAEKRKDDALAKqneaqqaesdanaAANDAQSRGEQDAsaaENKANQAQ 1766
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1238-1514 3.63e-05

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 49.53  E-value: 3.63e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1238 FRNQ-LEE-NTFTR-RTLEDHLKRkdlsLNDLEQQknklMEELRRKRdneeELLKLIKQMEKDLAfqkqvaekqlkekqk 1314
Cdd:COG4913  213 VREYmLEEpDTFEAaDALVEHFDD----LERAHEA----LEDAREQI----ELLEPIRELAERYA--------------- 265

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1315 ielEARRKITEIQYtcrenalpvcpitqatscrAVTGLQQEHDKQKAEELKQQVDELTAANRKAEQDMRELTYELNALQL 1394
Cdd:COG4913  266 ---AARERLAELEY-------------------LRAALRLWFAQRRLELLEAELEELRAELARLEAELERLEARLDALRE 323

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1395 EKTSSEEKARLLK-DKLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLNQT----TGKAEEAMQEASDLKKIKRNY 1469
Cdd:COG4913  324 ELDELEAQIRGNGgDRLEQLEREIERLERELEERERRRARLEALLAALGLPLPASaeefAALRAEAAALLEALEEELEAL 403

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 4502443  1470 QLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFRDE 1514
Cdd:COG4913  404 EEALAEAEAALRDLRRELRELEAEIASLERRKSNIPARLLALRDA 448
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 1236-1871 3.91e-05

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 49.66  E-value: 3.91e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1236 LNFRNQLEENTFTRRTLEDHLKR---KDLSLNDLEQQKNKLMEELRRKRDN---EEELLK----LIKQMEKDLAFQKQVA 1305
Cdd:TIGR01612  561 HEIKKELEEENEDSIHLEKEIKDlfdKYLEIDDEIIYINKLKLELKEKIKNisdKNEYIKkaidLKKIIENNNAYIDELA 640

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1306 E-------KQLKEKQKIELEARRKITEIqYTCRENALpvcpITQATSCRAVTGLQQEHDKQKAEELKQQVDELTAAnrka 1378
Cdd:TIGR01612  641 KispyqvpEHLKNKDKIYSTIKSELSKI-YEDDIDAL----YNELSSIVKENAIDNTEDKAKLDDLKSKIDKEYDK---- 711

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1379 EQDMRELTYELNALQLEKTSSEEKARLLKDK---LDETNNTLRCLKLELERKDqaekgysqqlRELGRQLNQTTGKAEEA 1455
Cdd:TIGR01612  712 IQNMETATVELHLSNIENKKNELLDIIVEIKkhiHGEINKDLNKILEDFKNKE----------KELSNKINDYAKEKDEL 781

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1456 MQEASDLKKIKRNY--QLELESLNHEKGKLQREVDR-ITRAHAVAEKNIQHLNSQIHSFRDEKeLERLQICQRKSDHLKE 1532
Cdd:TIGR01612  782 NKYKSKISEIKNHYndQINIDNIKDEDAKQNYDKSKeYIKTISIKEDEIFKIINEMKFMKDDF-LNKVDKFINFENNCKE 860

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1533 QFEKSHEQ---LLQNIKAEKENndkiQRLNEELEKSNECAEMLkqkveeltrqnNETKlmmQRIQAESENIvlekQTIQQ 1609
Cdd:TIGR01612  861 KIDSEHEQfaeLTNKIKAEISD----DKLNDYEKKFNDSKSLI-----------NEIN---KSIEEEYQNI----NTLKK 918

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1610 RCEALKIqadgFKDQLRSTNEHLHKQTKTEQDFQRKIKCLeedlaKSQNLVSefKQKCDQQNIIIQNTKKEVRNLNAELN 1689
Cdd:TIGR01612  919 VDEYIKI----CENTKESIEKFHNKQNILKEILNKNIDTI-----KESNLIE--KSYKDKFDNTLIDKINELDKAFKDAS 987

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1690 ASKEEKRrgeqkvqlqqaqvqelNNRLKKVQDEL--HLKTIEEQMTHRKMVLFQEESGKFKQSAEEFRKKMEKLmesKVI 1767
Cdd:TIGR01612  988 LNDYEAK----------------NNELIKYFNDLkaNLGKNKENMLYHQFDEKEKATNDIEQKIEDANKNIPNI---EIA 1048

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1768 TENDISGIrldfvsLQQENSRAQENAKLCETNI-KELERQLQQYREQMQQGQHMEANHYQKCQ--KLEDELIAQKREVEN 1844
Cdd:TIGR01612 1049 IHTSIYNI------IDEIEKEIGKNIELLNKEIlEEAEINITNFNEIKEKLKHYNFDDFGKEEniKYADEINKIKDDIKN 1122

                          650       660
                   ....*....|....*....|....*..
gi 4502443    1845 LKQKMDQQIKEHEhqlvllqcEIQKKS 1871
Cdd:TIGR01612 1123 LDQKIDHHIKALE--------EIKKKS 1141
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1143-1326 4.02e-05

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 49.24  E-value: 4.02e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1143 LERMVAELKKQKSRVEEELPKVR---EAAENELRKQQRNVEDISLqkiraESEAKQYRRELETIvrekeaaERELERVRQ 1219
Cdd:COG3206  166 LELRREEARKALEFLEEQLPELRkelEEAEAALEEFRQKNGLVDL-----SEEAKLLLQQLSEL-------ESQLAEARA 233

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1220 LTIEAEAKRAAVEENLLNFRNQLEE--NTFTRRTLEDHLKRKDLSLNDLEQQ---KNKLMEELRRKRDN-EEELLKLIKQ 1293
Cdd:COG3206  234 ELAEAEARLAALRAQLGSGPDALPEllQSPVIQQLRAQLAELEAELAELSARytpNHPDVIALRAQIAAlRAQLQQEAQR 313

                        170       180       190
                 ....*....|....*....|....*....|...
gi 4502443  1294 MEKDLAFQKQVAEKQLKEKQKIELEARRKITEI 1326
Cdd:COG3206  314 ILASLEAELEALQAREASLQAQLAQLEARLAEL 346
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1166-1723 4.16e-05

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 49.14  E-value: 4.16e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1166 EAAENELRKQQRNVEdiSLQKIRAESEA-KQYRRELETIVREKEA-----AERELERVRQLTIEAEAKRAAVEENLLNFR 1239
Cdd:COG4913  238 ERAHEALEDAREQIE--LLEPIRELAERyAAARERLAELEYLRAAlrlwfAQRRLELLEAELEELRAELARLEAELERLE 315

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1240 NQLEENTFTRRTLEDHLKRKDLS-LNDLEQQKNKLMEELRRKRDNEEELLKLIKQmekdLAFQKQVAEKQLKEKQKIELE 1318
Cdd:COG4913  316 ARLDALREELDELEAQIRGNGGDrLEQLEREIERLERELEERERRRARLEALLAA----LGLPLPASAEEFAALRAEAAA 391

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1319 ARRKITEIQytcrenalpvcpitqatscravtglqqehdkqkaEELKQQVDELTAANRKAEQDMRELTYELNALQLEKTS 1398
Cdd:COG4913  392 LLEALEEEL----------------------------------EALEEALAEAEAALRDLRRELRELEAEIASLERRKSN 437

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1399 SEEKARLLKDKL-DETNNTLRCLK-----LELERKDQA------------------EKGYSQQLRE------LGRQLNqt 1448
Cdd:COG4913  438 IPARLLALRDALaEALGLDEAELPfvgelIEVRPEEERwrgaiervlggfaltllvPPEHYAAALRwvnrlhLRGRLV-- 515

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1449 TGKAEEAMQEAsDLKKIKRN---YQLELES------LNHEKGK------------LQREVDRITRA------HAVAEKNI 1501
Cdd:COG4913  516 YERVRTGLPDP-ERPRLDPDslaGKLDFKPhpfrawLEAELGRrfdyvcvdspeeLRRHPRAITRAgqvkgnGTRHEKDD 594

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1502 QHLNSQIH--SFRDEKELERLQicqRKSDHLKEQFEKSHEQLlQNIKAEKENNDKIQRLNEELEKSNECAEMLKQKVEEL 1579
Cdd:COG4913  595 RRRIRSRYvlGFDNRAKLAALE---AELAELEEELAEAEERL-EALEAELDALQERREALQRLAEYSWDEIDVASAEREI 670

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1580 TRQNNetklmmQRIQAESENIVLEkqtiqqrceALKIQADGFKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNL 1659
Cdd:COG4913  671 AELEA------ELERLDASSDDLA---------ALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDR 735

                        570       580       590       600       610       620
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 4502443  1660 VSEFKQKCDQQniiiqntkkEVRNLNAELNASKEEKRRGEQKVQLQQaQVQELNNRLKKVQDEL 1723
Cdd:COG4913  736 LEAAEDLARLE---------LRALLEERFAAALGDAVERELRENLEE-RIDALRARLNRAEEEL 789
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 853-1465 4.55e-05

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 49.07  E-value: 4.55e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443     853 KNTQAAEALVKLYETKLCEEEAVIADKNNIENL---ISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDL 929
Cdd:pfam12128  310 LSAADAAVAKDRSELEALEDQHGAFLDADIETAaadQEQLPSWQSELENLEERLKALTGKHQDVTAKYNRRRSKIKEQNN 389

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443     930 -DFDWHKEKADQLVERWQNVHVQIDNRLRDLEgigkslkyyrdtyHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQ 1008
Cdd:pfam12128  390 rDIAGIKDKLAKIREARDRQLAVAEDDLQALE-------------SELREQLEAGKLEFNEEEYRLKSRLGELKLRLNQA 456

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1009 KMLVSEIEMKQSKMDECQKYAEQYSATVKDYElqtmtyramvDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLM 1088
Cdd:pfam12128  457 TATPELLLQLENFDERIERAREEQEAANAEVE----------RLQSELRQARKRRDQASEALRQASRRLEERQSALDELE 526

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1089 TQYIKFAGdSLKRLEEEEIKRCKETSEHGAYSDLLQR-------QKATVLENSKLTGKISELERM-VAELKKQKSRVEEE 1160
Cdd:pfam12128  527 LQLFPQAG-TLLHFLRKEAPDWEQSIGKVISPELLHRtdldpevWDGSVGGELNLYGVKLDLKRIdVPEWAASEEELRER 605

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1161 LPKVREAAENELRKQQRnvedislqkirAESEAKQYRRELETIVREKEAAEREL----ERVRQLTIEAEAKRAAVEENLL 1236
Cdd:pfam12128  606 LDKAEEALQSAREKQAA-----------AEEQLVQANGELEKASREETFARTALknarLDLRRLFDEKQSEKDKKNKALA 674

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1237 NFRNQLEENtftRRTLEDHLKRKDLSLND-LEQQKnklmeelRRKRDNEEELLKLIKQMEKDLAFQkQVAEKQLKEKQKI 1315
Cdd:pfam12128  675 ERKDSANER---LNSLEAQLKQLDKKHQAwLEEQK-------EQKREARTEKQAYWQVVEGALDAQ-LALLKAAIAARRS 743

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1316 ELEARRKITEIQYTCRENALPVCPITQATSCRAVTGLQQ-----EHDKQKA--------EELKQQVDELTAANRKAEQDM 1382
Cdd:pfam12128  744 GAKAELKALETWYKRDLASLGVDPDVIAKLKREIRTLERkieriAVRRQEVlryfdwyqETWLQRRPRLATQLSNIERAI 823

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1383 RELTYELNALQ------LEKTSSEEKArlLKDKLDETNNTLRCLKLELER---------KDQAEKGYSQQLRELGRQLNQ 1447
Cdd:pfam12128  824 SELQQQLARLIadtklrRAKLEMERKA--SEKQQVRLSENLRGLRCEMSKlatlkedanSEQAQGSIGERLAQLEDLKLK 901

                          650
                   ....*....|....*...
gi 4502443    1448 TTGKAEEAMQEASDLKKI 1465
Cdd:pfam12128  902 RDYLSESVKKYVEHFKNV 919
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 1121-1455 5.00e-05

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 48.74  E-value: 5.00e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1121 DLLQRQKATV--LENSKLTGKIS--ELERMVAELKKQKSRVEEELPKVREAAENELRKQ---QRNVEDISLQKI---RAE 1190
Cdd:pfam07888   45 ELLQAQEAANrqREKEKERYKRDreQWERQRRELESRVAELKEELRQSREKHEELEEKYkelSASSEELSEEKDallAQR 124

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1191 SEAKQYRRELE----TIVREKEAAERELERVRQLTIEAEAKRAAVEENLLNFRNQLEENTFTRRTL-------EDHLKRK 1259
Cdd:pfam07888  125 AAHEARIRELEedikTLTQRVLERETELERMKERAKKAGAQRKEEEAERKQLQAKLQQTEEELRSLskefqelRNSLAQR 204

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1260 DLSLNDLEQQKNKLMEEL---RRKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCRENALP 1336
Cdd:pfam07888  205 DTQVLQLQDTITTLTQKLttaHRKEAENEALLEELRSLQERLNASERKVEGLGEELSSMAAQRDRTQAELHQARLQAAQL 284

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1337 VCPITQAT----SCRAVTGLQQEHDKQKAEELKQQVDELTAANRKAEQDMRELTYELNALQLE----KTSSEEKARLLKD 1408
Cdd:pfam07888  285 TLQLADASlalrEGRARWAQERETLQQSAEADKDRIEKLSAELQRLEERLQEERMEREKLEVElgreKDCNRVQLSESRR 364

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*..
gi 4502443    1409 KLDETNNTLRCLKLELERKdQAEKgysQQLRELGRQLNQTTGKAEEA 1455
Cdd:pfam07888  365 ELQELKASLRVAQKEKEQL-QAEK---QELLEYIRQLEQRLETVADA 407
COG5022 COG5022
Myosin heavy chain [General function prediction only];
1077-1449 6.44e-05

Myosin heavy chain [General function prediction only];


Pssm-ID: 227355 [Multi-domain]  Cd Length: 1463  Bit Score: 48.92  E-value: 6.44e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1077 LRTRYTALVTLMT--QYIKFAGDSLKRLEEEEIKRCketsehgaysDLLQRQKATVLENSKLTGK-ISELERMVAELKKQ 1153
Cdd:COG5022  760 LRRRYLQALKRIKkiQVIQHGFRLRRLVDYELKWRL----------FIKLQPLLSLLGSRKEYRSyLACIIKLQKTIKRE 829

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1154 KsrveeelpKVREAAENELRkqqRNVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLTIEAEAKRAA--- 1230
Cdd:COG5022  830 K--------KLRETEEVEFS---LKAEVLIQKFGRSLKAKKRFSLLKKETIYLQSAQRVELAERQLQELKIDVKSISslk 898

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1231 -----VEENLLNFRNQLEENTFTR--------RTLEDHLKRKDL---SLNDLEQQK--NKLMEELRRKRDNEEELLKLIK 1292
Cdd:COG5022  899 lvnleLESEIIELKKSLSSDLIENlefkteliARLKKLLNNIDLeegPSIEYVKLPelNKLHEVESKLKETSEEYEDLLK 978

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1293 QMEKdLAFQKQVAEKQLKEKQKIELEARRKITEIQY---TCRENALPVCPITQATS--CRAVTGLQQEHDKQKAEELKQQ 1367
Cdd:COG5022  979 KSTI-LVREGNKANSELKNFKKELAELSKQYGALQEstkQLKELPVEVAELQSASKiiSSESTELSILKPLQKLKGLLLL 1057

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1368 VDELTAANRKAEQDMRELT--YELNALQLEKTSSEEKARLLKD-KLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQ 1444
Cdd:COG5022 1058 ENNQLQARYKALKLRRENSllDDKQLYQLESTENLLKTINVKDlEVTNRNLVKPANVLQFIVAQMIKLNLLQEISKFLSQ 1137


                 ....*
gi 4502443  1445 LNQTT 1449
Cdd:COG5022 1138 LVNTL 1142
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 1437-1601 7.15e-05

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 46.84  E-value: 7.15e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1437 QLRELGRQLNQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFRDEKE 1516
Cdd:COG1579   11 DLQELDSELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLGNVRNNKE 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1517 LERLqicQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEELEKSNECaemLKQKVEELTRQNNETKLMMQRIQAE 1596
Cdd:COG1579   91 YEAL---QKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAE---LEEKKAELDEELAELEAELEELEAE 164


                 ....*
gi 4502443  1597 SENIV 1601
Cdd:COG1579  165 REELA 169
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1082-1308 7.31e-05

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 47.90  E-value: 7.31e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1082 TALVTLMTQYIKFAGDSLKRLEEE--EIKRCKETSEhGAYSDLLQRQKATVLENSKLTGKISELERMVAELKKQKSRVEE 1159
Cdd:COG3883    1 ALALALAAPTPAFADPQIQAKQKElsELQAELEAAQ-AELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1160 ELPKVREAAENELRKQQRNVEDISLQKIRAESE-AKQYRRELETIVREKEAAERELERVRQLTIEAEAKRAAVEENLLNF 1238
Cdd:COG3883   80 EIEERREELGERARALYRSGGSVSYLDVLLGSEsFSDFLDRLSALSKIADADADLLEELKADKAELEAKKAELEAKLAEL 159

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1239 RNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQ 1308
Cdd:COG3883  160 EALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAA 229
PRK01156 PRK01156
chromosome segregation protein; Provisional
 1381-1869 7.69e-05

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 48.36  E-value: 7.69e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1381 DMRELTYELNALQLEKTSSEEKARLLKDKLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLNQTTGKAEEAMQEAS 1460
Cdd:PRK01156  177 MLRAEISNIDYLEEKLKSSNLELENIKKQIADDEKSHSITLKEIERLSIEYNNAMDDYNNLKSALNELSSLEDMKNRYES 256

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1461 DLKKIKRNYQLELESLNHEKGkLQREVDRITRAHAVAEKN------------------IQHLNSQIHSFRDE-KELERLQ 1521
Cdd:PRK01156  257 EIKTAESDLSMELEKNNYYKE-LEERHMKIINDPVYKNRNyindyfkykndienkkqiLSNIDAEINKYHAIiKKLSVLQ 335

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1522 icQRKSDHLKEQFEKshEQLLQNIKAEKENNDKIQRLNEELEKSNECAEMLKQKVEELTRQNNETklmMQRIQAESENIV 1601
Cdd:PRK01156  336 --KDYNDYIKKKSRY--DDLNNQILELEGYEMDYNSYLKSIESLKKKIEEYSKNIERMSAFISEI---LKIQEIDPDAIK 408

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1602 LEKQTIQQRCEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQRKIKC------LEEDlaKSQNLVSEFKQKCDQQNIIIQ 1675
Cdd:PRK01156  409 KELNEINVKLQDISSKVSSLNQRIRALRENLDELSRNMEMLNGQSVCpvcgttLGEE--KSNHIINHYNEKKSRLEEKIR 486

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1676 NTKKEVRNLNAELNASKEEKRRgeqkvqLQQAQVQELNNRLKKVQDELH-LKTIEEQMTHRKmvlfqEESGKFKQSAEEF 1754
Cdd:PRK01156  487 EIEIEVKDIDEKIVDLKKRKEY------LESEEINKSINEYNKIESARAdLEDIKIKINELK-----DKHDKYEEIKNRY 555

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1755 RKKMEKLMESK---------VITENDISGIRLDFVSLQQE----NSRAQE-------NAKLCETNIKELERQLQQYREQM 1814
Cdd:PRK01156  556 KSLKLEDLDSKrtswlnalaVISLIDIETNRSRSNEIKKQlndlESRLQEieigfpdDKSYIDKSIREIENEANNLNNKY 635

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 4502443   1815 QQGQHMEANHYQKCQKLED--ELIAQKREVENLKQKMDQQIKEHEHQLVLLQCEIQK 1869
Cdd:PRK01156  636 NEIQENKILIEKLRGKIDNykKQIAEIDSIIPDLKEITSRINDIEDNLKKSRKALDD 692
COG1340 COG1340
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];
1366-1655 8.06e-05

Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];


Pssm-ID: 440951 [Multi-domain]  Cd Length: 297  Bit Score: 47.21  E-value: 8.06e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1366 QQVDELTAANRKAEQDMRELTYELNALQLEKTSSEEKARLLKDKLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQL 1445
Cdd:COG1340    1 SKTDELSSSLEELEEKIEELREEIEELKEKRDELNEELKELAEKRDELNAQVKELREEAQELREKRDELNEKVKELKEER 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1446 NQTTGKAEEAMQEASDLKKIKRNYQLELESLNhekgKLQREVDRItrahavaEKNIQhlnSQIHSFRDEKEL-ERLQICQ 1524
Cdd:COG1340   81 DELNEKLNELREELDELRKELAELNKAGGSID----KLRKEIERL-------EWRQQ---TEVLSPEEEKELvEKIKELE 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1525 RKSDHLKEQFEKSHE--QLLQNIKAEKENNDKI-QRLNEELEKSNEC-AEM--LKQKVEELTRQNNETKLMMQRIQAESE 1598
Cdd:COG1340  147 KELEKAKKALEKNEKlkELRAELKELRKEAEEIhKKIKELAEEAQELhEEMieLYKEADELRKEADELHKEIVEAQEKAD 226

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 4502443  1599 NIVLEKQTIQQRCEALKIQADGFKDQLRSTnehlhKQTKTEQDFQRKIKCLEEDLAK 1655
Cdd:COG1340  227 ELHEEIIELQKELRELRKELKKLRKKQRAL-----KREKEKEELEEKAEEIFEKLKK 278
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1621-1818 9.39e-05

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 47.84  E-value: 9.39e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1621 FKDQLRSTNEHLHKQT-KTEQDFQRKIKCLEEDLAKSQNLVSEFKQKCDQqniiIQNTKKEVRNLNAELNASKEEKRRGE 1699
Cdd:COG4717   47 LLERLEKEADELFKPQgRKPELNLKELKELEEELKEAEEKEEEYAELQEE----LEELEEELEELEAELEELREELEKLE 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1700 QKVQLQQ--AQVQELNNRLKKVQDELhlKTIEEQMTHRKMVLFQEESgkFKQSAEEFRKKMEKLMESK-VITENDISGIR 1776
Cdd:COG4717  123 KLLQLLPlyQELEALEAELAELPERL--EELEERLEELRELEEELEE--LEAELAELQEELEELLEQLsLATEEELQDLA 198

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 4502443  1777 LDFVSLQQENSRAQENAKLCETNIKELERQLQQYREQMQQGQ 1818
Cdd:COG4717  199 EELEELQQRLAELEEELEEAQEELEELEEELEQLENELEAAA 240
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1148-1381 9.56e-05

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 47.52  E-value: 9.56e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1148 AELKKQKSRVEEELpkvrEAAENELRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERvRQLTIEAEAK 1227
Cdd:COG3883   19 QAKQKELSELQAEL----EAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEE-RREELGERAR 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1228 RAAVEENLLNFRNQLeentFTRRTLEDHLKRKDLsLNDLEQQKNKLMEELRRKRDNEEELLKLIKQMEKDLAFQKQVAEK 1307
Cdd:COG3883   94 ALYRSGGSVSYLDVL----LGSESFSDFLDRLSA-LSKIADADADLLEELKADKAELEAKKAELEAKLAELEALKAELEA 168

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 4502443  1308 QLKEKQKIELEARRKITEIQytcrenalpvcpITQATSCRAVTGLQQEHDKQKAEELKQQVDELTAANRKAEQD 1381
Cdd:COG3883  169 AKAELEAQQAEQEALLAQLS------------AEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAA 230
Spectrin pfam00435
Spectrin repeat; Spectrin repeat-domains are found in several proteins involved in ...
 375-469 9.88e-05

Spectrin repeat; Spectrin repeat-domains are found in several proteins involved in cytoskeletal structure. These include spectrin, alpha-actinin and dystrophin. The sequence repeat used in this family is taken from the structural repeat in reference. The spectrin domain- repeat forms a three helix bundle. The second helix is interrupted by proline in some sequences. The repeats are defined by a characteriztic tryptophan (W) residue at position 17 in helix A and a leucine (L) at 2 residues from the carboxyl end of helix C. Although the domain occurs in multiple repeats along sequences, the domains are actually stable on their own - ie they act, biophysically, like domains rather than repeats that along function when aggregated.


Pssm-ID: 395348 [Multi-domain]  Cd Length: 105  Bit Score: 43.85  E-value: 9.88e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443     375 LHNFVSRATNELIWLNEKEE----EEVAYDWSErntnIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTI 450
Cdd:pfam00435    3 LQQFFRDADDLESWIEEKEAllssEDYGKDLES----VQALLKKHKALEAELAAHQDRVEALNELAEKLIDEGHYASEEI 78

                           90
                   ....*....|....*....
gi 4502443     451 EAYRAAMQTQWSWILQLCQ 469
Cdd:pfam00435   79 QERLEELNERWEQLLELAA 97
mukB PRK04863
chromosome partition protein MukB;
1167-1564 1.30e-04

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 47.64  E-value: 1.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1167 AAENELRKQQRNVEDI--SLQKIRAESEAKQYR-----RELETIVREKEAAERELERVR---QLTIEAEA-----KRAAV 1231
Cdd:PRK04863  276 RHANERRVHLEEALELrrELYTSRRQLAAEQYRlvemaRELAELNEAESDLEQDYQAASdhlNLVQTALRqqekiERYQA 355

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1232 EENLLNFRnqLEENTFTRrtledhlkrkdlslndlEQQKNKLMEELRRKRDNEEELLKLikqmekdlafQKQVAEKQlke 1311
Cdd:PRK04863  356 DLEELEER--LEEQNEVV-----------------EEADEQQEENEARAEAAEEEVDEL----------KSQLADYQ--- 403

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1312 kQKIELEARRKIteiQYTCRENALpvcpiTQATSCRAVTGLQQEHDKQKAEELKQQVDELTAANRKAEQDMR-------- 1383
Cdd:PRK04863  404 -QALDVQQTRAI---QYQQAVQAL-----ERAKQLCGLPDLTADNAEDWLEEFQAKEQEATEELLSLEQKLSvaqaahsq 474

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1384 -ELTYEL---------------NALQLEKTSSEEKArllkdkLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLNQ 1447
Cdd:PRK04863  475 fEQAYQLvrkiagevsrseawdVARELLRRLREQRH------LAEQLQQLRMRLSELEQRLRQQQRAERLLAEFCKRLGK 548

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1448 TTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRITRahavaekNIQHLNSQIHSFRDEKE-LERLQicqrk 1526
Cdd:PRK04863  549 NLDDEDELEQLQEELEARLESLSESVSEARERRMALRQQLEQLQA-------RIQRLAARAPAWLAAQDaLARLR----- 616

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*...
gi 4502443   1527 sDHLKEQFEKSHE------QLLQNIKAEKENNDKI----QRLNEELEK 1564
Cdd:PRK04863  617 -EQSGEEFEDSQDvteymqQLLERERELTVERDELaarkQALDEEIER 663
EzrA pfam06160
Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like ...
 1152-1591 1.34e-04

Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like cell-division protein FtsZ polymerizes into a ring structure that establishes the location of the nascent division site. EzrA modulates the frequency and position of FtsZ ring formation. The structure contains 5 spectrin like alpha helical repeats.


Pssm-ID: 428797 [Multi-domain]  Cd Length: 542  Bit Score: 47.16  E-value: 1.34e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1152 KQKSRVEEELPKVREAAEN-ELRKQQRNVEDISLQKIRAESEAKQYRRELETIV----REKEAAERELERVRQLTIEAEA 1226
Cdd:pfam06160   60 KSLPDIEELLFEAEELNDKyRFKKAKKALDEIEELLDDIEEDIKQILEELDELLeseeKNREEVEELKDKYRELRKTLLA 139

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1227 KRAAVEENLLNFRNQLEE-----NTFTRRTLE-DHLKRKDLsLNDLEQQKNKLMEELrrkrdneEELLKLIKQMEKDlaF 1300
Cdd:pfam06160  140 NRFSYGPAIDELEKQLAEieeefSQFEELTESgDYLEAREV-LEKLEEETDALEELM-------EDIPPLYEELKTE--L 209

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1301 QKQVAE-----KQLKEKQKI--ELEARRKITEIqytcrenalpvcpitqatscravtglqqehdKQKAEELKQQVDELTA 1373
Cdd:pfam06160  210 PDQLEElkegyREMEEEGYAleHLNVDKEIQQL-------------------------------EEQLEENLALLENLEL 258

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1374 ANrkAEQDMRELTYELNAL--QLEKtssEEKARL--------LKDKLDETNNTLRCLKLELERKDQA----------EKG 1433
Cdd:pfam06160  259 DE--AEEALEEIEERIDQLydLLEK---EVDAKKyveknlpeIEDYLEHAEEQNKELKEELERVQQSytlnenelerVRG 333

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1434 YSQQLRELGRQLNQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFRd 1513
Cdd:pfam06160  334 LEKQLEELEKRYDEIVERLEEKEVAYSELQEELEEILEQLEEIEEEQEEFKESLQSLRKDELEAREKLDEFKLELREIK- 412

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1514 eKELERLQIcQRKSDHLKEQFEKSHEQL--LQNIKAEKENNdkIQRLNEELEKSNECAEMLKQKVEELTRQNNETKLMMQ 1591
Cdd:pfam06160  413 -RLVEKSNL-PGLPESYLDYFFDVSDEIedLADELNEVPLN--MDEVNRLLDEAQDDVDTLYEKTEELIDNATLAEQLIQ 488
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1670-1870 1.35e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 47.07  E-value: 1.35e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1670 QNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQLQQAQVQELNNRLKKVQDELhlKTIEEQMThrkmvLFQEESGKFKQ 1749
Cdd:COG4942   18 QADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRI--RALEQELA-----ALEAELAELEK 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1750 SAEEFRKKMEKLME--SKVITENDISGI--RLDFVSLQQENSRAQENAKLCETNIKELERQLQQYREQMQQGQHMEA--- 1822
Cdd:COG4942   91 EIAELRAELEAQKEelAELLRALYRLGRqpPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAele 170

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 4502443  1823 NHYQKCQKLEDELIAQKREVENLKQKMDQQIKEHEHQLVLLQCEIQKK 1870
Cdd:COG4942  171 AERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAEL 218
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 1626-1873 1.37e-04

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 47.43  E-value: 1.37e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1626 RSTNEHlHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQ--KCDQQNIIIQNT-KKEVRNLNAELNASKEEKRRGEQKV 1702
Cdd:pfam17380  282 KAVSER-QQQEKFEKMEQERLRQEKEEKAREVERRRKLEEaeKARQAEMDRQAAiYAEQERMAMERERELERIRQEERKR 360

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1703 QLQQAQVQELNNRLKKVQdELHLKTIEEQMTHRKMVLFQEESGKFKQSAEEFRKKMEKLMeskvitendisgIRLDFVSL 1782
Cdd:pfam17380  361 ELERIRQEEIAMEISRMR-ELERLQMERQQKNERVRQELEAARKVKILEEERQRKIQQQK------------VEMEQIRA 427

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1783 QQENSRAQENAKLCETNIKELERQLQQYREQMQQGQHM---EANHYQKCQKLEDELIAQKREVENLKQKMDQQIKEHEHQ 1859
Cdd:pfam17380  428 EQEEARQREVRRLEEERAREMERVRLEEQERQQQVERLrqqEEERKRKKLELEKEKRDRKRAEEQRRKILEKELEERKQA 507

                          250       260
                   ....*....|....*....|.
gi 4502443    1860 LV-------LLQCEIQKKSTA 1873
Cdd:pfam17380  508 MIeeerkrkLLEKEMEERQKA 528
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1654-1864 1.45e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 46.75  E-value: 1.45e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1654 AKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQLQQAQVQELNNRLKKVQDELHLKtiEEQMT 1733
Cdd:COG3883   12 AFADPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEER--REELG 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1734 HRkMVLFQEESGKFK--------QSAEEFRKKMEKLmesKVITENDISGIRlDFVSLQQENSRAQENAKLCETNIKELER 1805
Cdd:COG3883   90 ER-ARALYRSGGSVSyldvllgsESFSDFLDRLSAL---SKIADADADLLE-ELKADKAELEAKKAELEAKLAELEALKA 164

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 4502443  1806 QLQQYREQMQQGQhmeanhyQKCQKLEDELIAQKREVENLKQKMDQQIKEHEHQLVLLQ 1864
Cdd:COG3883  165 ELEAAKAELEAQQ-------AEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAA 216
PLEC smart00250
Plectin repeat;
2515-2552 1.51e-04

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 40.93  E-value: 1.51e-04
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 4502443     2515 QQLRQCELVITGIGHPITNKMMSVVEAVNANIINKEMG 2552
Cdd:smart00250    1 QRLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
PLEC smart00250
Plectin repeat;
2242-2274 1.51e-04

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 40.93  E-value: 1.51e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 4502443     2242 KHILEAQIASGGVIDPVRGIRVPPEIALQQGLL 2274
Cdd:smart00250    1 QRLLEAQSAIGGIIDPETGQKLSVEEALRRGLI 33
PRK12705 PRK12705
hypothetical protein; Provisional
 1172-1326 1.53e-04

hypothetical protein; Provisional


Pssm-ID: 237178 [Multi-domain]  Cd Length: 508  Bit Score: 47.01  E-value: 1.53e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1172 LRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLTIEAEAKRAavEENLLNFRNQLEENTFTRRT 1251
Cdd:PRK12705   25 LKKRQRLAKEAERILQEAQKEAEEKLEAALLEAKELLLRERNQQRQEARREREELQRE--EERLVQKEEQLDARAEKLDN 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1252 LEDHLKRKDLSLND----LEQQKNKLMEELRRKRDNEEELLK--LIKQMEKDLAFQKQVAEKQLKEkqKIELEARRKITE 1325
Cdd:PRK12705  103 LENQLEEREKALSAreleLEELEKQLDNELYRVAGLTPEQARklLLKLLDAELEEEKAQRVKKIEE--EADLEAERKAQN 180


                  .
gi 4502443   1326 I 1326
Cdd:PRK12705  181 I 181
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 1139-1298 1.83e-04

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 45.69  E-value: 1.83e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1139 KISELERMVAELKKQKSRVEEELpkvrEAAENELRKQQRNVEDISLQKIRAESEAKQYRRELETI---------VREKEA 1209
Cdd:COG1579   18 ELDRLEHRLKELPAELAELEDEL----AALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYeeqlgnvrnNKEYEA 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1210 AERELErvrqltiEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKDlslNDLEQQKNKLMEELRRKRDNEEELLK 1289
Cdd:COG1579   94 LQKEIE-------SLKRRISDLEDEILELMERIEELEEELAELEAELAELE---AELEEKKAELDEELAELEAELEELEA 163


                 ....*....
gi 4502443  1290 LIKQMEKDL 1298
Cdd:COG1579  164 EREELAAKI 172
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 1141-1757 1.83e-04

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 47.14  E-value: 1.83e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1141 SELERMVAELKKQKSRVEEELP--KVREA---AENELRKQQRNvEDISLQKIRAESEAKqyRRELETIVREKEAA----E 1211
Cdd:pfam12128  426 EQLEAGKLEFNEEEYRLKSRLGelKLRLNqatATPELLLQLEN-FDERIERAREEQEAA--NAEVERLQSELRQArkrrD 502

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1212 RELERVRQLTIEAEAKRAAVEE----------NLLNFRN---QLEENTFTRRTLEDHLKRKDL-----------SLN--- 1264
Cdd:pfam12128  503 QASEALRQASRRLEERQSALDElelqlfpqagTLLHFLRkeaPDWEQSIGKVISPELLHRTDLdpevwdgsvggELNlyg 582

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1265 ---DLEQ----QKNKLMEELRRKRDNEEELLK----LIKQMEKDLAfqkqVAEKQLKEKQKIELEARRKITEiqytCREN 1333
Cdd:pfam12128  583 vklDLKRidvpEWAASEEELRERLDKAEEALQsareKQAAAEEQLV----QANGELEKASREETFARTALKN----ARLD 654

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1334 alpvcpitqatscravtgLQQEHDKQKAEELKQQvDELTAANRKAEQDMRELTYELNALQLEktsseekarlLKDKLDET 1413
Cdd:pfam12128  655 ------------------LRRLFDEKQSEKDKKN-KALAERKDSANERLNSLEAQLKQLDKK----------HQAWLEEQ 705

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1414 NNTLRCLKLELERKDQAEKGysqqlrELGRQLNQ-TTGKAEEAMQEASDLKKIKRNYQLELESLNhekgklqrevdritr 1492
Cdd:pfam12128  706 KEQKREARTEKQAYWQVVEG------ALDAQLALlKAAIAARRSGAKAELKALETWYKRDLASLG--------------- 764

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1493 ahaVAEKNIQHLNSQIHSFrdEKELERlqICQRKSDHLKEQFEKSHEQLLQNikaekenndkiQRLNEELEKSNECAEML 1572
Cdd:pfam12128  765 ---VDPDVIAKLKREIRTL--ERKIER--IAVRRQEVLRYFDWYQETWLQRR-----------PRLATQLSNIERAISEL 826

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1573 KQkveELTRQNNETKLmmQRIQAESENIVLEKQTIQqrceaLKIQADGFKDQLRSTNE-HLHKQT-KTEQDFQRKIKCLE 1650
Cdd:pfam12128  827 QQ---QLARLIADTKL--RRAKLEMERKASEKQQVR-----LSENLRGLRCEMSKLATlKEDANSeQAQGSIGERLAQLE 896

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1651 EDLAKSQNLVSEFKQKCDQQNIIIqntKKEVRNLNAELNASKEEKRRGEQKVQLQQAQVQELnnrLKKVQDELHLKTIEE 1730
Cdd:pfam12128  897 DLKLKRDYLSESVKKYVEHFKNVI---ADHSGSGLAETWESLREEDHYQNDKGIRLLDYRKL---VPYLEQWFDVRVPQS 970

                          650       660
                   ....*....|....*....|....*...
gi 4502443    1731 QMTHRKMV-LFQEESGKFKQSAEEFRKK 1757
Cdd:pfam12128  971 IMVLREQVsILGVDLTEFYDVLADFDRR 998
PRK11281 PRK11281
mechanosensitive channel MscK;
1358-1596 1.86e-04

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 47.21  E-value: 1.86e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1358 KQKAEELKQQVDEltaanrkAEQDMRELTYELNALQlEKTSSEEKARL-------LKDKLDETNNTLRCLKLEL------ 1424
Cdd:PRK11281   79 KEETEQLKQQLAQ-------APAKLRQAQAELEALK-DDNDEETRETLstlslrqLESRLAQTLDQLQNAQNDLaeynsq 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1425 --------ERKDQAEKGYSQQLRELGRQLNqtTGKAEEAMQEASDLKKikrnYQLELESLNhEKGKLQREV--------D 1488
Cdd:PRK11281  151 lvslqtqpERAQAALYANSQRLQQIRNLLK--GGKVGGKALRPSQRVL----LQAEQALLN-AQNDLQRKSlegntqlqD 223

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1489 RITRAHAVAEKNIQHLNSQIHSFRDEKELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKI-QRLNEELEKSNe 1567
Cdd:PRK11281  224 LLQKQRDYLTARIQRLEHQLQLLQEAINSKRLTLSEKTVQEAQSQDEAARIQANPLVAQELEINLQLsQRLLKATEKLN- 302

                         250       260       270
                  ....*....|....*....|....*....|
gi 4502443   1568 caemlkqkveELTRQNNETKLMMQR-IQAE 1596
Cdd:PRK11281  303 ----------TLTQQNLRVKNWLDRlTQSE 322
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
1378-1640 1.97e-04

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 46.43  E-value: 1.97e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1378 AEQDMRELTYELNALQLEKTSSEEKARLLKDKLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLNQTTGKAEEAMQ 1457
Cdd:COG4372   29 LSEQLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQEELESLQE 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1458 EASDLKKIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFRDEKELERLQICQRKSDHLKEQFEKS 1537
Cdd:COG4372  109 EAEELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEELAALEQELQALSEAEAEQALDEL 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1538 HEQLLQNIKAEKENNDKIQRLNEELEKSNECAEMLKQKVEELTRQNNETKLMMQRIQAESENIVLEKQTIQQRCEALKIQ 1617
Cdd:COG4372  189 LKEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLDALELEEDKEELLEEVILKEIEELELAIL 268

                        250       260
                 ....*....|....*....|...
gi 4502443  1618 ADGFKDQLRSTNEHLHKQTKTEQ 1640
Cdd:COG4372  269 VEKDTEEEELEIAALELEALEEA 291
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 1124-1579 2.41e-04

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 46.71  E-value: 2.41e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1124 QRQKATVLENskltgKISELERMVAELKKQKSRVEEElpkvREAAENELRKQQ-------RNVEDISLQKIRAESEAKQY 1196
Cdd:pfam01576  592 QRQLVSNLEK-----KQKKFDQMLAEEKAISARYAEE----RDRAEAEAREKEtralslaRALEEALEAKEELERTNKQL 662

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1197 RRELETIVREKEAAER---ELERvrqltieaeAKRAAvEENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQ---- 1269
Cdd:pfam01576  663 RAEMEDLVSSKDDVGKnvhELER---------SKRAL-EQQVEEMKTQLEELEDELQATEDAKLRLEVNMQALKAQferd 732

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1270 ---KNKLMEELRRK-----RDNEEELLKLIKQMEKDLAFQKQV------AEKQLKEKQKIELEARRKITEIQYTCRENAL 1335
Cdd:pfam01576  733 lqaRDEQGEEKRRQlvkqvRELEAELEDERKQRAQAVAAKKKLeldlkeLEAQIDAANKGREEAVKQLKKLQAQMKDLQR 812

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1336 PvCPITQATSCRAVTGLQQEHDKQKA--EELKQQVDELTAANR---KAEQDMRELTYEL-------NALQLEKTSSEEKA 1403
Cdd:pfam01576  813 E-LEEARASRDEILAQSKESEKKLKNleAELLQLQEDLAASERarrQAQQERDELADEIasgasgkSALQDEKRRLEARI 891

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1404 RLLKDKLDETNNTLRCLKLELERKDQ----------AEKGYSQQLRELGRQLNQTTGKAEEAMQEASdlKKIKRNYQLEL 1473
Cdd:pfam01576  892 AQLEEELEEEQSNTELLNDRLRKSTLqveqlttelaAERSTSQKSESARQQLERQNKELKAKLQEME--GTVKSKFKSSI 969

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1474 ESLNHEKGKLQREVDRITRAHAVAEKNIQhlnsqihsfRDEKELERLQIC----QRKSDHLKEQFEKSHEQLLQNIKAEK 1549
Cdd:pfam01576  970 AALEAKIAQLEEQLEQESRERQAANKLVR---------RTEKKLKEVLLQvedeRRHADQYKDQAEKGNSRMKQLKRQLE 1040

                          490       500       510
                   ....*....|....*....|....*....|....*..
gi 4502443    1550 ENNDKIQRLN-------EELEKSNECAEMLKQKVEEL 1579
Cdd:pfam01576 1041 EAEEEASRANaarrklqRELDDATESNESMNREVSTL 1077
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 1197-1605 2.59e-04

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 46.43  E-value: 2.59e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1197 RRELETIVREKEAAERELERVRQltieaEAKRAaveenllnfRNQLEEntfTRRTLEDHLKRkdlslndleqqknkLMEE 1276
Cdd:pfam07888   40 LQERAELLQAQEAANRQREKEKE-----RYKRD---------REQWER---QRRELESRVAE--------------LKEE 88

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1277 LRRKRDNEEEllklikqmekdlafqkqvaekqLKEKQKIELEARRKITEIqytcrenalpvcpitqatscRAVTGLQQEH 1356
Cdd:pfam07888   89 LRQSREKHEE----------------------LEEKYKELSASSEELSEE--------------------KDALLAQRAA 126

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1357 DKQKAEELKQQVDELTAANRKAEQDMRELTYELNALQLEKTSSEEKARLLKDKLDETNNTLRCLKLELE--RKDQAEKGY 1434
Cdd:pfam07888  127 HEARIRELEEDIKTLTQRVLERETELERMKERAKKAGAQRKEEEAERKQLQAKLQQTEEELRSLSKEFQelRNSLAQRDT 206

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1435 S-QQLRELGRQLNQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVdritrAHAVAEKNiqHLNSQIHSFRD 1513
Cdd:pfam07888  207 QvLQLQDTITTLTQKLTTAHRKEAENEALLEELRSLQERLNASERKVEGLGEEL-----SSMAAQRD--RTQAELHQARL 279

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1514 EKELERLQICQrKSDHLKE---QFEKSHEQLLQNIKAEKennDKIQRLNEELEKSNEC---AEMLKQKVE---------- 1577
Cdd:pfam07888  280 QAAQLTLQLAD-ASLALREgraRWAQERETLQQSAEADK---DRIEKLSAELQRLEERlqeERMEREKLEvelgrekdcn 355

                          410       420       430
                   ....*....|....*....|....*....|...
gi 4502443    1578 -----ELTRQNNETKLMMQRIQAESENIVLEKQ 1605
Cdd:pfam07888  356 rvqlsESRRELQELKASLRVAQKEKEQLQAEKQ 388
PRK09039 PRK09039
peptidoglycan -binding protein;
1420-1581 4.12e-04

peptidoglycan -binding protein;


Pssm-ID: 181619 [Multi-domain]  Cd Length: 343  Bit Score: 45.34  E-value: 4.12e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1420 LKLELERKDQAekgysqqLRELGRQLNQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEK 1499
Cdd:PRK09039   44 LSREISGKDSA-------LDRLNSQIAELADLLSLERQGNQDLQDSVANLRASLSAAEAERSRLQALLAELAGAGAAAEG 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1500 NIQHLNSQIHSFRDEKELERLQIcqrksDHLKEQFEKSHEQL--LQNI-----KAEKENNDKIQRLNEELEKSnecaemL 1572
Cdd:PRK09039  117 RAGELAQELDSEKQVSARALAQV-----ELLNQQIAALRRQLaaLEAAldaseKRDRESQAKIADLGRRLNVA------L 185


                  ....*....
gi 4502443   1573 KQKVEELTR 1581
Cdd:PRK09039  186 AQRVQELNR 194
DUF4670 pfam15709
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ...
 1142-1327 4.20e-04

Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.


Pssm-ID: 464815 [Multi-domain]  Cd Length: 522  Bit Score: 45.71  E-value: 4.20e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1142 ELERMVAELKKQKSRVEEELPKVREAAENELRKQQRNVEDISLQKIRAESEakQYRREletivrekeaaerELERVRQLT 1221
Cdd:pfam15709  349 EVERKRREQEEQRRLQQEQLERAEKMREELELEQQRRFEEIRLRKQRLEEE--RQRQE-------------EEERKQRLQ 413

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1222 IEAEAKRAaveenllnfRNQLEEntFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKLIKQMEKDLAFQ 1301
Cdd:pfam15709  414 LQAAQERA---------RQQQEE--FRRKLQELQRKKQQEEAERAEAEKQRQKELEMQLAEEQKRLMEMAEEERLEYQRQ 482

                          170       180
                   ....*....|....*....|....*.
gi 4502443    1302 KQVAEkqlkEKQKIELEARRKITEIQ 1327
Cdd:pfam15709  483 KQEAE----EKARLEAEERRQKEEEA 504
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 745-943 4.42e-04

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 45.87  E-value: 4.42e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443     745 EVRNIRLRLENC---EDRLIRQIRTPLERddlhESVFRiTEQEKLKKELERLKDDLGTITNKCEE-FFSQAAASSSVPTL 820
Cdd:pfam05483  514 ELKKHQEDIINCkkqEERMLKQIENLEEK----EMNLR-DELESVREEFIQKGDEVKCKLDKSEEnARSIEYEVLKKEKQ 588

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443     821 RSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEA-LVKLYETKLCEEEAVIAD-KNNIENLISTlkqWRSEVDE 898
Cdd:pfam05483  589 MKILENKCNNLKKQIENKNKNIEELHQENKALKKKGSAENkQLNAYEIKVNKLELELASaKQKFEEIIDN---YQKEIED 665

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 4502443     899 KRQVFHALEDELQKAKAISDEMFKTYKERDLD-----------FDWHKEKADQLVE 943
Cdd:pfam05483  666 KKISEEKLLEEVEKAKAIADEAVKLQKEIDKRcqhkiaemvalMEKHKHQYDKIIE 721
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 1359-1863 4.62e-04

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 45.98  E-value: 4.62e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1359 QKAEELKQQVDELTAANRKAEQDMRELTYELNALQlektssEEKARLLKDKLDEtnntlrcLKLELERKDQaekgYSQQL 1438
Cdd:pfam12128  294 TLDDQWKEKRDELNGELSAADAAVAKDRSELEALE------DQHGAFLDADIET-------AAADQEQLPS----WQSEL 356

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1439 RELGRQLNQTTGKAEEaMQEASDLKKIKRNYQLELE-SLNHEKGKLQREVdrITRAHAVAEKNIQHL--------NSQIH 1509
Cdd:pfam12128  357 ENLEERLKALTGKHQD-VTAKYNRRRSKIKEQNNRDiAGIKDKLAKIREA--RDRQLAVAEDDLQALeselreqlEAGKL 433

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1510 SFRDEK----------------------ELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEELEKSNE 1567
Cdd:pfam12128  434 EFNEEEyrlksrlgelklrlnqatatpeLLLQLENFDERIERAREEQEAANAEVERLQSELRQARKRRDQASEALRQASR 513

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1568 CAEMLKQKVEELTRQ------------NNETKLMMQRI---------------------QAESEN----IVLEKQTIQ-- 1608
Cdd:pfam12128  514 RLEERQSALDELELQlfpqagtllhflRKEAPDWEQSIgkvispellhrtdldpevwdgSVGGELnlygVKLDLKRIDvp 593

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1609 ---QRCEALKIQADGFK--------------DQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQKCDQQ- 1670
Cdd:pfam12128  594 ewaASEEELRERLDKAEealqsarekqaaaeEQLVQANGELEKASREETFARTALKNARLDLRRLFDEKQSEKDKKNKAl 673

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1671 NIIIQNTKKEVRNLNAELNASKEekrrgEQKVQLQQAQVQELNNRLKKVQDELHL-KTIEEQMTHRKMVLFQEESGKfKQ 1749
Cdd:pfam12128  674 AERKDSANERLNSLEAQLKQLDK-----KHQAWLEEQKEQKREARTEKQAYWQVVeGALDAQLALLKAAIAARRSGA-KA 747

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1750 SAEEFRKKMEKLMESKVITENDISGIRLDFVSLQQENSRAQENaklcETNIKELERQLQ-QYREQMQQGQHMEANHYQKC 1828
Cdd:pfam12128  748 ELKALETWYKRDLASLGVDPDVIAKLKREIRTLERKIERIAVR----RQEVLRYFDWYQeTWLQRRPRLATQLSNIERAI 823

                          570       580       590
                   ....*....|....*....|....*....|....*
gi 4502443    1829 QKLEDELIAQKREVENLKQKMDQQIKEHEHQLVLL 1863
Cdd:pfam12128  824 SELQQQLARLIADTKLRRAKLEMERKASEKQQVRL 858
PRK12704 PRK12704
phosphodiesterase; Provisional
 1154-1334 4.70e-04

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 45.54  E-value: 4.70e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1154 KSRVEEELPKVREAAENELRKQQRNVEDISLQKIR-AESEAKQYRRELETIVREKEaaeRELERVrqltieaeakraavE 1232
Cdd:PRK12704   26 KKIAEAKIKEAEEEAKRILEEAKKEAEAIKKEALLeAKEEIHKLRNEFEKELRERR---NELQKL--------------E 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1233 ENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKLIKQMEKDLAfqKQVAEKQLKEk 1312
Cdd:PRK12704   89 KRLLQKEENLDRKLELLEKREEELEKKEKELEQKQQELEKKEEELEELIEEQLQELERISGLTAEEA--KEILLEKVEE- 165

                         170       180
                  ....*....|....*....|..
gi 4502443   1313 qKIELEARRKITEIQYTCRENA 1334
Cdd:PRK12704  166 -EARHEAAVLIKEIEEEAKEEA 186
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
1135-1220 6.53e-04

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 45.23  E-value: 6.53e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1135 KLTGKISELERMVAELKKQKSRVEEELPKVREAAENELRKQqrnvedislQKIRA-ESEAKQYRRELETIVREKEAAERE 1213
Cdd:COG2433  424 RLEAEVEELEAELEEKDERIERLERELSEARSEERREIRKD---------REISRlDREIERLERELEEERERIEELKRK 494


                 ....*..
gi 4502443  1214 LERVRQL 1220
Cdd:COG2433  495 LERLKEL 501
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 1531-1875 7.44e-04

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 45.11  E-value: 7.44e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1531 KEQFEKSHEQLLQNIKaekennDKIQRLNEELEKSNECAEMLKQKVEELtrqnnETKLmmQRIQAESENIVLEKQTIQQR 1610
Cdd:pfam15921   73 KEHIERVLEEYSHQVK------DLQRRLNESNELHEKQKFYLRQSVIDL-----QTKL--QEMQMERDAMADIRRRESQS 139

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1611 CEALKiqadgfkDQLRSTNEHLHKQtkteqdfqrkiKCLEEDLAKSQNL-VSEFKQKCDQQNIIIQntkkEVRNLNAELN 1689
Cdd:pfam15921  140 QEDLR-------NQLQNTVHELEAA-----------KCLKEDMLEDSNTqIEQLRKMMLSHEGVLQ----EIRSILVDFE 197

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1690 ASKEEKRRgeQKVQLQQAQVQELNNRLKKVqdelhLKTIEEQMTHRKMVLFQEESgKFKQSAEEFRKKMEKLMES-KVIT 1768
Cdd:pfam15921  198 EASGKKIY--EHDSMSTMHFRSLGSAISKI-----LRELDTEISYLKGRIFPVED-QLEALKSESQNKIELLLQQhQDRI 269

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1769 ENDISGIRLDFVSLQQENSRAQENAKlcetnikELERQLQQYREQMQQGQHMEANHYQKCQKLEDELIAQKREVenlKQK 1848
Cdd:pfam15921  270 EQLISEHEVEITGLTEKASSARSQAN-------SIQSQLEIIQEQARNQNSMYMRQLSDLESTVSQLRSELREA---KRM 339

                          330       340
                   ....*....|....*....|....*..
gi 4502443    1849 MDQQIKEHEHQLVLLQCEIQKKSTAKD 1875
Cdd:pfam15921  340 YEDKIEELEKQLVLANSELTEARTERD 366
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1067-1295 7.50e-04

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 45.01  E-value: 7.50e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1067 ADLIIQEFMD--LRTRYTALvtlmTQYIKFAGDSLKRLEEEeikrcKETSEHgAYSDLLQRQKATVL--ENSKLTGKISE 1142
Cdd:COG3206  154 ANALAEAYLEqnLELRREEA----RKALEFLEEQLPELRKE-----LEEAEA-ALEEFRQKNGLVDLseEAKLLLQQLSE 223

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1143 LERMVAELKKQKSRVEEELPKVREAAENELRKQQRNVEDISLQKIRAE-SEAKQYRRELETIVREK----EAAERELERV 1217
Cdd:COG3206  224 LESQLAEARAELAEAEARLAALRAQLGSGPDALPELLQSPVIQQLRAQlAELEAELAELSARYTPNhpdvIALRAQIAAL 303

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1218 RQLtIEAEAKRAaveenLLNFRNQLEENTFTRRTLE---DHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKLIKQM 1294
Cdd:COG3206  304 RAQ-LQQEAQRI-----LASLEAELEALQAREASLQaqlAQLEARLAELPELEAELRRLEREVEVARELYESLLQRLEEA 377


                 .
gi 4502443  1295 E 1295
Cdd:COG3206  378 R 378
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1371-1582 8.23e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 44.37  E-value: 8.23e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1371 LTAANRKAEQDMRELTYELNALQLEKTSSEEKARLLKDKLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLNQTTG 1450
Cdd:COG4942   11 LALAAAAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEK 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1451 KAEEAMQEasdLKKIKRNYQLELESL----NHEKGKL---QREVDRITRAHAVAEKNIQHLNSQIHSFRDE-KELERLQI 1522
Cdd:COG4942   91 EIAELRAE---LEAQKEELAELLRALyrlgRQPPLALllsPEDFLDAVRRLQYLKYLAPARREQAEELRADlAELAALRA 167

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4502443  1523 CQRKSDHLKEQFEKSHEQLLQNIKAEK-ENNDKIQRLNEELEKSNECAEMLKQKVEELTRQ 1582
Cdd:COG4942  168 ELEAERAELEALLAELEEERAALEALKaERQKLLARLEKELAELAAELAELQQEAEELEAL 228
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
 1353-1852 1.02e-03

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 44.43  E-value: 1.02e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1353 QQEHDKQKAEELKQQVDELTAANRKAEQDMRELTYELNALQLEKTSSEEKARLLKDKL---DETNNTLR----CLKLELE 1425
Cdd:pfam10174  276 QMEVYKSHSKFMKNKIDQLKQELSKKESELLALQTKLETLTNQNSDCKQHIEVLKESLtakEQRAAILQtevdALRLRLE 355

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1426 RKDQAEKGYSQQLRELGRQLNQTTGKAEEaMQEASDLKKIKRNyqleleslnhekgklqrevdritrahaVAEKNIQHLN 1505
Cdd:pfam10174  356 EKESFLNKKTKQLQDLTEEKSTLAGEIRD-LKDMLDVKERKIN---------------------------VLQKKIENLQ 407

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1506 SQIhsfRD-EKEL----ERLQICQRKSDHLK------EQFEKSHEQLLQNIKAEKENNDKIQRlnEELEKSNECAEMLKQ 1574
Cdd:pfam10174  408 EQL---RDkDKQLaglkERVKSLQTDSSNTDtalttlEEALSEKERIIERLKEQREREDRERL--EELESLKKENKDLKE 482

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1575 KVEELTRQNNETKLMMQRIQAESENIVLEKQTIQQRCEALKIQADGFKDQLRSTNEHLHK------QTKTEQDFQRKIKC 1648
Cdd:pfam10174  483 KVSALQPELTEKESSLIDLKEHASSLASSGLKKDSKLKSLEIAVEQKKEECSKLENQLKKahnaeeAVRTNPEINDRIRL 562

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1649 LEEDlaksqnlVSEFKQKCDQqniiiqnTKKEVRNLNAELNASKEEKRRGEQKVqlqqAQVQELNNRLKKVQD--ELHLK 1726
Cdd:pfam10174  563 LEQE-------VARYKEESGK-------AQAEVERLLGILREVENEKNDKDKKI----AELESLTLRQMKEQNkkVANIK 624

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1727 TIEEQMTHRKMVLFQEESGKFKQSAEEFR-KKMEKLME--SKVITENDISGIRLDfvSLQQenSRAQENAKLceTNIK-E 1802
Cdd:pfam10174  625 HGQQEMKKKGAQLLEEARRREDNLADNSQqLQLEELMGalEKTRQELDATKARLS--STQQ--SLAEKDGHL--TNLRaE 698

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4502443    1803 LERQLQQYREQMQQG-----QHMEAN------HYQKCQKLEDELIAQKREVENLKQKMDQQ 1852
Cdd:pfam10174  699 RRKQLEEILEMKQEAllaaiSEKDANiallelSSSKKKKTQEEVMALKREKDRLVHQLKQQ 759
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 1142-1322 1.07e-03

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 44.07  E-value: 1.07e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1142 ELERMVAELKKQKSRVEEELPKVREAAENelRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAERElervrqlt 1221
Cdd:TIGR02794   51 QANRIQQQKKPAAKKEQERQKKLEQQAEE--AEKQRAAEQARQKELEQRAAAEKAAKQAEQAAKQAEEKQKQ-------- 120

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1222 iEAEAKRAAVEEnllnfRNQLEENTFTRRTLEDHLKRKDlslndlEQQKNKLMEELRRKRDnEEELLKLIKQMEKDLAFQ 1301
Cdd:TIGR02794  121 -AEEAKAKQAAE-----AKAKAEAEAERKAKEEAAKQAE------EEAKAKAAAEAKKKAE-EAKKKAEAEAKAKAEAEA 187

                          170       180
                   ....*....|....*....|....*
gi 4502443    1302 KQVAE----KQLKEKQKIELEARRK 1322
Cdd:TIGR02794  188 KAKAEeakaKAEAAKAKAAAEAAAK 212
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1278-1564 1.12e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 44.52  E-value: 1.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1278 RRKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIeLEARRKITEIQYTcrenalpvcPITQATSCRAVTGLQQEHD 1357
Cdd:COG4913  609 RAKLAALEAELAELEEELAEAEERLEALEAELDALQER-REALQRLAEYSWD---------EIDVASAEREIAELEAELE 678

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1358 KQKA-----EELKQQVDELTAANRKAEQDMRELTYELNALQLEKTSSEEKARLLKDKLDEtnntlrclklelerkdqAEK 1432
Cdd:COG4913  679 RLDAssddlAALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEA-----------------AED 741

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1433 GYSQQLRELGRQlnqttgKAEEAMQEASdLKKIKRNYQLELESLNHEKGKLQREVDRITRAH-AVAEKNIQHLNSQIHSF 1511
Cdd:COG4913  742 LARLELRALLEE------RFAAALGDAV-ERELRENLEERIDALRARLNRAEEELERAMRAFnREWPAETADLDADLESL 814

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4502443  1512 RD-EKELERLqicqrKSDHLKEQFEKSHEQLLQNIKAEKEN------------NDKIQRLNEELEK 1564
Cdd:COG4913  815 PEyLALLDRL-----EEDGLPEYEERFKELLNENSIEFVADllsklrraireiKERIDPLNDSLKR 875
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1064-1234 1.18e-03

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 44.24  E-value: 1.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1064 QSSADLIIQEFMDLRTRYTALvTLMTQYIKFAGDSLKRLEEEEIKRCKETSEHGAYSDLLQRQKATVLE----NSKLTGK 1139
Cdd:COG3206  211 SEEAKLLLQQLSELESQLAEA-RAELAEAEARLAALRAQLGSGPDALPELLQSPVIQQLRAQLAELEAElaelSARYTPN 289

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1140 ISELERMVAELKKQKSRVEEELPKVREAAENELRKQQRNVEDISLQKIRAESEAKQY---RRELETIVREKEAAERELER 1216
Cdd:COG3206  290 HPDVIALRAQIAALRAQLQQEAQRILASLEAELEALQAREASLQAQLAQLEARLAELpelEAELRRLEREVEVARELYES 369

                        170
                 ....*....|....*...
gi 4502443  1217 VRQLTIEAEAKRAAVEEN 1234
Cdd:COG3206  370 LLQRLEEARLAEALTVGN 387
GAS pfam13851
Growth-arrest specific micro-tubule binding; This family is the highly conserved central ...
 1536-1722 1.39e-03

Growth-arrest specific micro-tubule binding; This family is the highly conserved central region of a number of metazoan proteins referred to as growth-arrest proteins. In mouse, Gas8 is predominantly a testicular protein, whose expression is developmentally regulated during puberty and spermatogenesis. In humans, it is absent in infertile males who lack the ability to generate gametes. The localization of Gas8 in the motility apparatus of post-meiotic gametocytes and mature spermatozoa, together with the detection of Gas8 also in cilia at the apical surfaces of epithelial cells lining the pulmonary bronchi and Fallopian tubes suggests that the Gas8 protein may have a role in the functioning of motile cellular appendages. Gas8 is a microtubule-binding protein localized to regions of dynein regulation in mammalian cells.


Pssm-ID: 464001 [Multi-domain]  Cd Length: 200  Bit Score: 42.59  E-value: 1.39e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1536 KSHEQLLQNIKA-----EKENNDKIQRLNEELEKSNECAEMLKQKVEELTRQNNETKLMMQriQAESENIVLEKQTIQQr 1610
Cdd:pfam13851    4 KNHEKAFNEIKNyyndiTRNNLELIKSLKEEIAELKKKEERNEKLMSEIQQENKRLTEPLQ--KAQEEVEELRKQLENY- 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1611 cEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQRKIKCLEED----LAKSQNLVSEFKQKCDQQNIIIQntkKEVRNLNA 1686
Cdd:pfam13851   81 -EKDKQSLKNLKARLKVLEKELKDLKWEHEVLEQRFEKVERErdelYDKFEAAIQDVQQKTGLKNLLLE---KKLQALGE 156

                          170       180       190
                   ....*....|....*....|....*....|....*...
gi 4502443    1687 ELNasKEEKRRGE--QKVQLQQAQVQELNNRLKKVQDE 1722
Cdd:pfam13851  157 TLE--KKEAQLNEvlAAANLDPDALQAVTEKLEDVLES 192
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
1156-1496 1.49e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 43.74  E-value: 1.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1156 RVEEELPKVREAAENELRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLTIEAEAKRAAVEENL 1235
Cdd:COG4372    3 RLGEKVGKARLSLFGLRPKTGILIAALSEQLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEEL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1236 LNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKI 1315
Cdd:COG4372   83 EELNEQLQAAQAELAQAQEELESLQEEAEELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESL 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1316 ELEARRKITEIQYTCRENALPVCPITQATSCRAVTGLQQEHDKQKAEELKQQVDELTAANRKAEQDMRELTYELNALQLE 1395
Cdd:COG4372  163 QEELAALEQELQALSEAEAEQALDELLKEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLDAL 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1396 KTSSEEKARLLKDKLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLKKIKRNYQLELES 1475
Cdd:COG4372  243 ELEEDKEELLEEVILKEIEELELAILVEKDTEEEELEIAALELEALEEAALELKLLALLLNLAALSLIGALEDALLAALL 322

                        330       340
                 ....*....|....*....|.
gi 4502443  1476 LNHEKGKLQREVDRITRAHAV 1496
Cdd:COG4372  323 ELAKKLELALAILLAELADLL 343
Filament pfam00038
Intermediate filament protein;
1141-1466 1.52e-03

Intermediate filament protein;


Pssm-ID: 459643 [Multi-domain]  Cd Length: 313  Bit Score: 43.37  E-value: 1.52e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1141 SELERMVAELKKQKSRVEEELPKVREAAENELRKQqrnVEDISLQKIRAESEAKQYRRELETiVREKEAAERelervrql 1220
Cdd:pfam00038   28 KLLETKISELRQKKGAEPSRLYSLYEKEIEDLRRQ---LDTLTVERARLQLELDNLRLAAED-FRQKYEDEL-------- 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1221 tieaeAKRAAVEENLLNFRNQLEENTFTRrtledhlkrkdlslNDLEQQKNKLMEELR-RKRDNEEEllklIKQMEKDLA 1299
Cdd:pfam00038   96 -----NLRTSAENDLVGLRKDLDEATLAR--------------VDLEAKIESLKEELAfLKKNHEEE----VRELQAQVS 152

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1300 FQKQVAEkqLKEKQKIEL-----EARRKITEIQYTCRENAlpvcpitqatscravtglqQEHDKQKAEELKQQVDELTAA 1374
Cdd:pfam00038  153 DTQVNVE--MDAARKLDLtsalaEIRAQYEEIAAKNREEA-------------------EEWYQSKLEELQQAAARNGDA 211

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1375 NRKAEQDMRELTYELNALQLEKTSSEEKARLLKDKLDETNntlrclklelERKDQAEKGYSQQLRELGRQLNQTTGKAEE 1454
Cdd:pfam00038  212 LRSAKEEITELRRTIQSLEIELQSLKKQKASLERQLAETE----------ERYELQLADYQELISELEAELQETRQEMAR 281

                          330
                   ....*....|..
gi 4502443    1455 AMQEASDLKKIK 1466
Cdd:pfam00038  282 QLREYQELLNVK 293
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 1550-1872 1.52e-03

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 43.94  E-value: 1.52e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1550 ENNDKIQRLNEELEKSNECAEMLKQKVEELTRQNnETKLMMQRIQAESENIVLEKQTIQQRCEALKIQAD--GFKDQLRS 1627
Cdd:pfam05483   71 ENSEGLSRLYSKLYKEAEKIKKWKVSIEAELKQK-ENKLQENRKIIEAQRKAIQELQFENEKVSLKLEEEiqENKDLIKE 149

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1628 TNEHLHKQTKTEQDFQR---KIKCLEEDLAKSQNLVSEFKQKCDQqnIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQL 1704
Cdd:pfam05483  150 NNATRHLCNLLKETCARsaeKTKKYEYEREETRQVYMDLNNNIEK--MILAFEELRVQAENARLEMHFKLKEDHEKIQHL 227

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1705 QQAQVQELNNRLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFKQSAEEFRKKMEKLMESKVITENDISGIRLDFVSLQQ 1784
Cdd:pfam05483  228 EEEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKANQLEEKTKLQDENLKELIEKKDHLTKELEDIKMSLQR 307

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1785 ENSRAQENAKLCETNIKELERQLQQYREQMQQGQHMEANHyqkcQKLEDELIAQKREVENLKQKMDQQIKEHEHQLVLLQ 1864
Cdd:pfam05483  308 SMSTQKALEEDLQIATKTICQLTEEKEAQMEELNKAKAAH----SFVVTEFEATTCSLEELLRTEQQRLEKNEDQLKIIT 383


                   ....*...
gi 4502443    1865 CEIQKKST 1872
Cdd:pfam05483  384 MELQKKSS 391
SPEC cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members ...
 868-1032 1.61e-03

Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; the repeats are independent folding units; tandem repeats are found in differing numbers and arrange in an antiparallel manner to form dimers; the repeats are defined by a characteristic tryptophan (W) residue in helix A and a leucine (L) at the carboxyl end of helix C and separated by a linker of 5 residues; two copies of the repeat are present here


Pssm-ID: 238103 [Multi-domain]  Cd Length: 213  Bit Score: 42.43  E-value: 1.61e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   868 KLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEdelQKAKAISDEmfktykeRDLDFDWHKEKADQLVERWQN 947
Cdd:cd00176   21 ELLSSTDYGDDLESVEALLKKHEALEAELAAHEERVEALN---ELGEQLIEE-------GHPDAEEIQERLEELNQRWEE 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   948 VHVQIDNRLRDLEGIGKSLKYYRDTYHpLDDWIQqvETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQK 1027
Cdd:cd00176   91 LRELAEERRQRLEEALDLQQFFRDADD-LEQWLE--EKEAALASEDLGKDLESVEELLKKHKELEEELEAHEPRLKSLNE 167


                 ....*
gi 4502443  1028 YAEQY 1032
Cdd:cd00176  168 LAEEL 172
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1451-1702 1.63e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 43.60  E-value: 1.63e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1451 KAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFrdEKELERLQicqRKSDHL 1530
Cdd:COG4942   21 AAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAAL--EAELAELE---KEIAEL 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1531 KEQFEKSHEQLLQNIKA--EKENNDKIQRL--NEELEKSNECAEMLKQKVEELTRQnnetklmMQRIQAESENIVLEKQT 1606
Cdd:COG4942   96 RAELEAQKEELAELLRAlyRLGRQPPLALLlsPEDFLDAVRRLQYLKYLAPARREQ-------AEELRADLAELAALRAE 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1607 IQQRCEALKiqadgfkdqlrstnehlhkQTKTEQDFQRKIkcLEEDLAKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLNA 1686
Cdd:COG4942  169 LEAERAELE-------------------ALLAELEEERAA--LEALKAERQKLLARLEKELAELAAELAELQQEAEELEA 227

                        250
                 ....*....|....*.
gi 4502443  1687 ELNASKEEKRRGEQKV 1702
Cdd:COG4942  228 LIARLEAEAAAAAERT 243
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1253-1461 1.63e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 43.28  E-value: 1.63e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1253 EDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKLIKQMEKDL-AFQKQV--AEKQLKEKQKIELEARRKITEI--- 1326
Cdd:COG3883   15 DPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELeALQAEIdkLQAEIAEAEAEIEERREELGERara 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1327 QYTCRENALPVCPITQATS----CRAVTGLQQ--EHDKQKAEELKQQVDELTAANRKAEQDMRELTYELNALQLEKTSSE 1400
Cdd:COG3883   95 LYRSGGSVSYLDVLLGSESfsdfLDRLSALSKiaDADADLLEELKADKAELEAKKAELEAKLAELEALKAELEAAKAELE 174

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4502443  1401 EKARLLKDKLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLNQTTGKAEEAMQEASD 1461
Cdd:COG3883  175 AQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAAAA 235
PRK01156 PRK01156
chromosome segregation protein; Provisional
 770-1299 1.83e-03

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 43.74  E-value: 1.83e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    770 RDDLHESvfrITEQEKLKKELERLKDDLGTITNKCEEFfsqAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVN 849
Cdd:PRK01156  189 EEKLKSS---NLELENIKKQIADDEKSHSITLKEIERL---SIEYNNAMDDYNNLKSALNELSSLEDMKNRYESEIKTAE 262

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    850 LVLKNTQAAEALVKLYETKL--CEEEAVIADKNNIENLISTLKQwrseVDEKRQVFHALEDELQKAKAISDEMFKTYKER 927
Cdd:PRK01156  263 SDLSMELEKNNYYKELEERHmkIINDPVYKNRNYINDYFKYKND----IENKKQILSNIDAEINKYHAIIKKLSVLQKDY 338

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    928 DlDFDWHKEKADQLverwqnvhvqiDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVEttqRKIQENQPENSKTLATQLNQ 1007
Cdd:PRK01156  339 N-DYIKKKSRYDDL-----------NNQILELEGYEMDYNSYLKSIESLKKKIEEYS---KNIERMSAFISEILKIQEID 403

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1008 QKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYR---AMVDSQQKSPVkrrrmqSSADLIIQEFMDLRTRYtal 1084
Cdd:PRK01156  404 PDAIKKELNEINVKLQDISSKVSSLNQRIRALRENLDELSrnmEMLNGQSVCPV------CGTTLGEEKSNHIINHY--- 474

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1085 vtlmtqyikfaGDSLKRLEEEEIKrcketsehgaysdllqrqkaTVLENSKLTGKISELERMVAELKKQKSRVEEELPKV 1164
Cdd:PRK01156  475 -----------NEKKSRLEEKIRE--------------------IEIEVKDIDEKIVDLKKRKEYLESEEINKSINEYNK 523

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1165 REAAENELRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLtIEAEAKRAAVEE-----NLLNFR 1239
Cdd:PRK01156  524 IESARADLEDIKIKINELKDKHDKYEEIKNRYKSLKLEDLDSKRTSWLNALAVISL-IDIETNRSRSNEikkqlNDLESR 602

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4502443   1240 NQLEENTF--TRRTLEDHLKRKDLSLNDLEQQKNKL------MEELRRKRDNEEELLKLIKQMEKDLA 1299
Cdd:PRK01156  603 LQEIEIGFpdDKSYIDKSIREIENEANNLNNKYNEIqenkilIEKLRGKIDNYKKQIAEIDSIIPDLK 670
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
 1090-1593 1.87e-03

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 43.58  E-value: 1.87e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1090 QYIKFAGDSLKR-LEEEEIKRCKETSEHGAYSDLLQRQKA-TVLENSKLTGKISELERMVAElKKQKSRVEEELPKVREA 1167
Cdd:pfam05557    5 IESKARLSQLQNeKKQMELEHKRARIELEKKASALKRQLDrESDRNQELQKRIRLLEKREAE-AEEALREQAELNRLKKK 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1168 AENELRKQQRN----VEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLTIEAEAKRAAVEENLLNFRNQLE 1243
Cdd:pfam05557   84 YLEALNKKLNEkesqLADAREVISCLKNELSELRRQIQRAELELQSTNSELEELQERLDLLKAKASEAEQLRQNLEKQQS 163

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1244 ENTFTR---RTLEDHL-------------KRKDLSLNDLEQQKNKLMEELRRKRDN-------EEELLKLIKQMEKDLAF 1300
Cdd:pfam05557  164 SLAEAEqriKELEFEIqsqeqdseivknsKSELARIPELEKELERLREHNKHLNENienklllKEEVEDLKRKLEREEKY 243

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1301 QKQVAEKQLkEKQKIELEARRKITEIQYTCRENALPVcpitqATSCRAVTGLQQEHD-KQKAEELKQQVDELTAANRKAE 1379
Cdd:pfam05557  244 REEAATLEL-EKEKLEQELQSWVKLAQDTGLNLRSPE-----DLSRRIEQLQQREIVlKEENSSLTSSARQLEKARRELE 317

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1380 QDMRELTYELNALQLEKTSSEEKARLLKDKLDETNNTLRCLKLELER--KDQAEKGYSQQLRELGRQLNQTTGK----AE 1453
Cdd:pfam05557  318 QELAQYLKKIEDLNKKLKRHKALVRRLQRRVLLLTKERDGYRAILESydKELTMSNYSPQLLERIEEAEDMTQKmqahNE 397

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1454 EAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRITRAHAVAE-----KNIQHLNSQIHSFRDEKELERLQICQR--- 1525
Cdd:pfam05557  398 EMEAQLSVAEEELGGYKQQAQTLERELQALRQQESLADPSYSKEEvdslrRKLETLELERQRLREQKNELEMELERRclq 477

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1526 --------KSDHL--------KEQFEKSHEQLLQNIKAEKENNDKIQRLNEELEKSNE-CAEMLKQKVEELTRQNNETKL 1588
Cdd:pfam05557  478 gdydpkktKVLHLsmnpaaeaYQQRKNQLEKLQAEIERLKRLLKKLEDDLEQVLRLPEtTSTMNFKEVLDLRKELESAEL 557


                   ....*
gi 4502443    1589 MMQRI 1593
Cdd:pfam05557  558 KNQRL 562
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
1649-1818 2.23e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 42.97  E-value: 2.23e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1649 LEEDLAKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQLQQAQVQELNNRLKKVQDELHLKTI 1728
Cdd:COG4372   15 LFGLRPKTGILIAALSEQLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEELEELNEQLQAAQA 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1729 EEQMTHRKMVLFQEESGKFKQSAEEFRKKMEKLMESKVITENDISGIRLDFVSLQQENSRAQENAKLCETNIKELERQLQ 1808
Cdd:COG4372   95 ELAQAQEELESLQEEAEELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEELAALEQELQ 174

                        170
                 ....*....|
gi 4502443  1809 QYREQMQQGQ 1818
Cdd:COG4372  175 ALSEAEAEQA 184
PLN02939 PLN02939
transferase, transferring glycosyl groups
 1343-1730 2.28e-03

transferase, transferring glycosyl groups


Pssm-ID: 215507 [Multi-domain]  Cd Length: 977  Bit Score: 43.35  E-value: 2.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1343 ATSCRAVTglQQEHDKQKAEELKQQVDELTAANRKAEQDMRELTYELNA-------LQLEKTSSEEKARLLKDKLDETNN 1415
Cdd:PLN02939   32 AVSCRARR--RGFSSQQKKKRGKNIAPKQRSSNSKLQSNTDENGQLENTslrtvmeLPQKSTSSDDDHNRASMQRDEAIA 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1416 TLRclKLELERKDQAEKGYSQQLRELGrQLNQTTGKAEEAMQEAsdlkkikRNYQLE-LESLNHEKGKLQREVDRI-TRA 1493
Cdd:PLN02939  110 AID--NEQQTNSKDGEQLSDFQLEDLV-GMIQNAEKNILLLNQA-------RLQALEdLEKILTEKEALQGKINILeMRL 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1494 HAVAEKNIQHLNSQIHSFRDEKELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEKEN-NDKIQRLNEELEKSNECAEML 1572
Cdd:PLN02939  180 SETDARIKLAAQEKIHVEILEEQLEKLRNELLIRGATEGLCVHSLSKELDVLKEENMLlKDDIQFLKAELIEVAETEERV 259

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1573 KQKVEELTRQNNETKLMMQRIQAESENiVLEKQTIQQRCEALKIqaDGFKDQLRSTNEHLHKQTKT---EQDFQRKIKCL 1649
Cdd:PLN02939  260 FKLEKERSLLDASLRELESKFIVAQED-VSKLSPLQYDCWWEKV--ENLQDLLDRATNQVEKAALVldqNQDLRDKVDKL 336

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1650 EEDLAKSQnlVSEFKQKcdqqniIIQNTKKEVRNLNAELNASKEEKrrgEQKVQLQQAQVQELNNRLKKVQDELHLKTIE 1729
Cdd:PLN02939  337 EASLKEAN--VSKFSSY------KVELLQQKLKLLEERLQASDHEI---HSYIQLYQESIKEFQDTLSKLKEESKKRSLE 405


                  .
gi 4502443   1730 E 1730
Cdd:PLN02939  406 H 406
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 1209-1564 2.45e-03

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 43.40  E-value: 2.45e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1209 AAERELERVRQLTIEAE-----AKRAAVEENLLNFRNQLEENTFTRRTLE-------DHLKrkdLSLNDLEQQknklmEE 1276
Cdd:COG3096  277 ANERRELSERALELRRElfgarRQLAEEQYRLVEMARELEELSARESDLEqdyqaasDHLN---LVQTALRQQ-----EK 348

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1277 LRRKRDNEEELlklikqmEKDLAFQKQVAEKqlKEKQKIELEARRKITE------------------------IQYTCRE 1332
Cdd:COG3096  349 IERYQEDLEEL-------TERLEEQEEVVEE--AAEQLAEAEARLEAAEeevdslksqladyqqaldvqqtraIQYQQAV 419

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1333 NALpvcpiTQATSCRAVTGLQQEHDKQKAEELKQQVDELTAANRKAEQDMR---------ELTYELnalqLEKTSSE--- 1400
Cdd:COG3096  420 QAL-----EKARALCGLPDLTPENAEDYLAAFRAKEQQATEEVLELEQKLSvadaarrqfEKAYEL----VCKIAGEver 490

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1401 ----EKAR-LLKD-----KLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLKKIKRNYQ 1470
Cdd:COG3096  491 sqawQTAReLLRRyrsqqALAQRLQQLRAQLAELEQRLRQQQNAERLLEEFCQRIGQQLDAAEELEELLAELEAQLEELE 570

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1471 LELESLNHEKGKLQREVDRITRahavaekNIQHLNSQIHSFRDEKE-LERLQicqrksDHLKEQFEKSHE------QLLQ 1543
Cdd:COG3096  571 EQAAEAVEQRSELRQQLEQLRA-------RIKELAARAPAWLAAQDaLERLR------EQSGEALADSQEvtaamqQLLE 637

                        410       420
                 ....*....|....*....|.
gi 4502443  1544 NIKAEKENNDKIQRLNEELEK 1564
Cdd:COG3096  638 REREATVERDELAARKQALES 658
CCCAP pfam15964
Centrosomal colon cancer autoantigen protein family; CCCAP is a family of proteins found in ...
 1104-1617 2.56e-03

Centrosomal colon cancer autoantigen protein family; CCCAP is a family of proteins found in eukaryotes. CCCAP is also known as SDCCAG8, serologically defined colon cancer antigen 8. It is associated with the centrosome.


Pssm-ID: 435040 [Multi-domain]  Cd Length: 703  Bit Score: 43.36  E-value: 2.56e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1104 EEEIKRCKETsehgaYSDLLQRQKATVLENSKLTGK---------ISELERMVAELKKQKSRVEEE-------------- 1160
Cdd:pfam15964  127 EAEVKFCKEE-----LSEMKQRVQVVVLENEKLQQElksqtqeetLREQTLLDSSGNMQNSWCTPEdsrvhqtskrpash 201

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1161 --LPKVREAAENELRKQQRNVEDISL----QKIRAESEAKQYRRELETIVREKEAAEREL------------ERVRQLTI 1222
Cdd:pfam15964  202 nlAERLKSATTGEDEKWRLELEKLKLlyeaKTEVLESQVKSLRKDLAESQKTCEDLKERLkhkeslvaastsSRVGGLCL 281

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1223 EAEAKRAAVEENLLNFRNQ-LEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEEL-------LKLIKQM 1294
Cdd:pfam15964  282 KCAQHEAVLAQTHTNVHMQtIERLTKERDDLMSALVSVRSSLAEAQQRESSAYEQVKQAVQMTEEAnfektkaLIQCEQL 361

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1295 EKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCRENALPvcpiTQATSCRAVTGLQQEHDKQKAEELKQQVDELTAA 1374
Cdd:pfam15964  362 KSELERQKERLEKELASQQEKRAQEKEALRKEMKKEREELGA----TMLALSQNVAQLEAQVEKVTREKNSLVSQLEEAQ 437

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1375 NRKAEQDMR------ELTYELNALQLEKTSSEEKARLLKDKLDEtnntlrclklELERKDQAEKGYSQQLRELGRQLNQT 1448
Cdd:pfam15964  438 KQLASQEMDvtkvcgEMRYQLNQTKMKKDEAEKEHREYRTKTGR----------QLEIKDQEIEKLGLELSESKQRLEQA 507

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1449 TGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRITRAHAV-AEKNIQHLNSQIHSF-----RDEKELERLQI 1522
Cdd:pfam15964  508 QQDAARAREECLKLTELLGESEHQLHLTRLEKESIQQSFSNEAKAQALqAQQREQELTQKMQQMeaqhdKTVNEQYSLLT 587

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1523 CQ---------------RKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEELE----KSNECAEMLKQKVEELTRQN 1583
Cdd:pfam15964  588 SQntfiaklkeecctlaKKLEEITQKSRSEVEQLSQEKEYLQDRLEKLQKRNEELEeqcvQHGRMHERMKQRLRQLDKHC 667

                          570       580       590
                   ....*....|....*....|....*....|....
gi 4502443    1584 NETKLMMQRIQAESENIVLEKQTIQQRCEALKIQ 1617
Cdd:pfam15964  668 QATAQQLVQLLSKQNQLFKERQNLTEEVQSLRSQ 701
PLEC smart00250
Plectin repeat;
2446-2476 2.59e-03

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 37.46  E-value: 2.59e-03
                            10        20        30
                    ....*....|....*....|....*....|.
gi 4502443     2446 SPVAGYWLTASGERISVLKASRRNLVDRITA 2476
Cdd:smart00250    8 SAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1608-1817 3.34e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 42.44  E-value: 3.34e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1608 QQRCEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLNAE 1687
Cdd:COG4942   19 ADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAE 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1688 LNASKEE-----------KRRGEQKVQLQQAQ----------VQELNNRLKKVQDELHLKTIEEQMTHRKMVLFQEESGK 1746
Cdd:COG4942   99 LEAQKEElaellralyrlGRQPPLALLLSPEDfldavrrlqyLKYLAPARREQAEELRADLAELAALRAELEAERAELEA 178

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4502443  1747 FKQSAEEFRKKMEKLMESKVITENDISGirlDFVSLQQENSRAQENAKLCETNIKELERQLQQYREQMQQG 1817
Cdd:COG4942  179 LLAELEEERAALEALKAERQKLLARLEK---ELAELAAELAELQQEAEELEALIARLEAEAAAAAERTPAA 246
DUF4659 pfam15558
Domain of unknown function (DUF4659); This family of proteins is found in eukaryotes. Proteins ...
 1258-1610 3.75e-03

Domain of unknown function (DUF4659); This family of proteins is found in eukaryotes. Proteins in this family are typically between 427 and 674 amino acids in length. There are two completely conserved residues (D and I) that may be functionally important.


Pssm-ID: 464768 [Multi-domain]  Cd Length: 374  Bit Score: 42.33  E-value: 3.75e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1258 RKDLSLNDLEQQKNKLMEELRRKRD-----NEEELLKLIKQMEKdlafQKQVAEKQLKEKQKIELEARRKITEIQYTCRE 1332
Cdd:pfam15558   18 KEEQRMRELQQQAALAWEELRRRDQkrqetLERERRLLLQQSQE----QWQAEKEQRKARLGREERRRADRREKQVIEKE 93

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1333 NalpvcpitqatSCRAVTGLQQEHDKQKAEELKQQVDELtaaNRKAEQDMRELTYELNALQlektssEEKARLLKDKLDE 1412
Cdd:pfam15558   94 S-----------RWREQAEDQENQRQEKLERARQEAEQR---KQCQEQRLKEKEEELQALR------EQNSLQLQERLEE 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1413 TNNTLRCLKLELERKDQAEKGYSQQLRELGRQLNQTTGKAEEAMQ----EASDLKKIKRNYQLELESLNHEKGKLQREVD 1488
Cdd:pfam15558  154 ACHKRQLKEREEQKKVQENNLSELLNHQARKVLVDCQAKAEELLRrlslEQSLQRSQENYEQLVEERHRELREKAQKEEE 233

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1489 RITRAHAVAEKniqhlnsqihsfRDEKELERLQICQRKSDHLKEQFEKSHEQLLQNiKAEkenndKIQRLNEELEKSNec 1568
Cdd:pfam15558  234 QFQRAKWRAEE------------KEEERQEHKEALAELADRKIQQARQVAHKTVQD-KAQ-----RARELNLEREKNH-- 293

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|...
gi 4502443    1569 aEMLKQKVEELTRQNNE-TKLMMQRIQAESENIVLEKQTIQQR 1610
Cdd:pfam15558  294 -HILKLKVEKEEKCHREgIKEAIKKKEQRSEQISREKEATLEE 335
PLN02939 PLN02939
transferase, transferring glycosyl groups
 1199-1427 3.91e-03

transferase, transferring glycosyl groups


Pssm-ID: 215507 [Multi-domain]  Cd Length: 977  Bit Score: 42.58  E-value: 3.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1199 ELETIVREKEAAEREL--------ERVRQLTIEAEAKRAA--VEENLLNFRNQLEENTFTRRTLE-------DHLKRKDL 1261
Cdd:PLN02939  157 DLEKILTEKEALQGKInilemrlsETDARIKLAAQEKIHVeiLEEQLEKLRNELLIRGATEGLCVhslskelDVLKEENM 236

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1262 SL-NDLEQQKNKLMEelrrKRDNEEELLKLikqmEKDLAFQKQvAEKQLKEKQKIELEARRKITEIQYTCR----EN--A 1334
Cdd:PLN02939  237 LLkDDIQFLKAELIE----VAETEERVFKL----EKERSLLDA-SLRELESKFIVAQEDVSKLSPLQYDCWwekvENlqD 307

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1335 LPVCPITQATscRAVTGLQQEHDkqkaeeLKQQVDELTAANRKAEQdMRELTYELNALQLEKTSSEEK-----------A 1403
Cdd:PLN02939  308 LLDRATNQVE--KAALVLDQNQD------LRDKVDKLEASLKEANV-SKFSSYKVELLQQKLKLLEERlqasdheihsyI 378

                         250       260
                  ....*....|....*....|....
gi 4502443   1404 RLLKDKLDETNNTLRCLKLELERK 1427
Cdd:PLN02939  379 QLYQESIKEFQDTLSKLKEESKKR 402
46 PHA02562
endonuclease subunit; Provisional
 1518-1732 4.06e-03

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 42.31  E-value: 4.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1518 ERLQICQRKSDHLKEQFeKSHEQLLQNIkaEKENNDKIQRLNEELEKSNECAEMLKQKVEELTRQ------------NNE 1585
Cdd:PHA02562  181 QQIQTLDMKIDHIQQQI-KTYNKNIEEQ--RKKNGENIARKQNKYDELVEEAKTIKAEIEELTDEllnlvmdiedpsAAL 257

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1586 TKLMMQRIQAES-------ENIVLEKQTIQQRCEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQN 1658
Cdd:PHA02562  258 NKLNTAAAKIKSkieqfqkVIKMYEKGGVCPTCTQQISEGPDRITKIKDKLKELQHSLEKLDTAIDELEEIMDEFNEQSK 337

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4502443   1659 LVSEFKQKCDQQNIIIQNTKKEVRNLNAEL-NASKEEKRRGEQKVQLQQaQVQELNNRLKKVQDELHLKTIEEQM 1732
Cdd:PHA02562  338 KLLELKNKISTNKQSLITLVDKAKKVKAAIeELQAEFVDNAEELAKLQD-ELDKIVKTKSELVKEKYHRGIVTDL 411
Nup88 pfam10168
Nuclear pore component; Nup88 can be divided into two structural domains; the N-terminal ...
 1630-1734 4.91e-03

Nuclear pore component; Nup88 can be divided into two structural domains; the N-terminal two-thirds of the protein has no obvious structural motifs but is the region for binding to Nup98, one of the components of the nuclear pore. the C-terminal end is a predicted coiled-coil domain. Nup88 is overexpressed in tumour cells.


Pssm-ID: 462975 [Multi-domain]  Cd Length: 713  Bit Score: 42.34  E-value: 4.91e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1630 EHLHKQTKTEQDFQRKIKCLE----------EDLAKSQNLVSE--------FKQKCDQQNIIIQNTKKEVRNLNAELNAS 1691
Cdd:pfam10168  547 EYLKKHDLAREEIQKRVKLLKlqkeqqlqelQSLEEERKSLSEraeklaekYEEIKDKQEKLMRRCKKVLQRLNSQLPVL 626

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 4502443    1692 KEEKRRGEQKVQLQQAQVQELNNRLKKVQdelhlKTIEEQMTH 1734
Cdd:pfam10168  627 SDAEREMKKELETINEQLKHLANAIKQAK-----KKMNYQRYQ 664
mukB PRK04863
chromosome partition protein MukB;
1103-1846 4.96e-03

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 42.64  E-value: 4.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1103 EEEEIKRcKETS---EHGAYSDLLQRqkatVLENSKLTGKIselERMVAELKKQKSRVEEELPKVREAAE----NELRKQ 1175
Cdd:PRK04863  315 ELAELNE-AESDleqDYQAASDHLNL----VQTALRQQEKI---ERYQADLEELEERLEEQNEVVEEADEqqeeNEARAE 386

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1176 QRNVEDISLQK---------IRAESEAKQYRReletivrekeaAERELERVRQLTIEAEAKRAAVEENLLNFRNQLEENT 1246
Cdd:PRK04863  387 AAEEEVDELKSqladyqqalDVQQTRAIQYQQ-----------AVQALERAKQLCGLPDLTADNAEDWLEEFQAKEQEAT 455

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1247 FTRRTLEDHLK----------------RK---DLSLNDLEQQKNKLMEELRRKR---DNEEELLKLIKQMEKDLAfQKQV 1304
Cdd:PRK04863  456 EELLSLEQKLSvaqaahsqfeqayqlvRKiagEVSRSEAWDVARELLRRLREQRhlaEQLQQLRMRLSELEQRLR-QQQR 534

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1305 AEKQLKEKQK----------------IELEARRK-ITEIQYTCREnalpvcpitQATSCRAvtglQQEHDKQKAEELKQQ 1367
Cdd:PRK04863  535 AERLLAEFCKrlgknlddedeleqlqEELEARLEsLSESVSEARE---------RRMALRQ----QLEQLQARIQRLAAR 601

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1368 VDELTAANRKAEQ----------DMRELTyELNALQLEKtssEEKARLLKDKLDETNntlRCLKLELERKDQAEKGYSQQ 1437
Cdd:PRK04863  602 APAWLAAQDALARlreqsgeefeDSQDVT-EYMQQLLER---ERELTVERDELAARK---QALDEEIERLSQPGGSEDPR 674

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1438 LRELGRQLNQ---TTGKAEEAMQEA----------------SDLKKIKRnyQLE-----------------------LES 1475
Cdd:PRK04863  675 LNALAERFGGvllSEIYDDVSLEDApyfsalygparhaivvPDLSDAAE--QLAgledcpedlyliegdpdsfddsvFSV 752

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1476 LNHEKGKLQREVDRITR----------AHAVAEKNIQHLNSQIHSF--RDEKELERLQICQRKSDHLkEQFEKSHEQLLQ 1543
Cdd:PRK04863  753 EELEKAVVVKIADRQWRysrfpevplfGRAAREKRIEQLRAEREELaeRYATLSFDVQKLQRLHQAF-SRFIGSHLAVAF 831

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1544 NIKAEKENNDKIQRLNEELEKSNECAEMLKQKVEELtRQNNETKLMMQRIQAESEniVLEKQTIQQRCEALKIQ------ 1617
Cdd:PRK04863  832 EADPEAELRQLNRRRVELERALADHESQEQQQRSQL-EQAKEGLSALNRLLPRLN--LLADETLADRVEEIREQldeaee 908

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1618 ADGFKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQKCDqqniiiqnTKKEVRNLNAELNASKEEKRR 1697
Cdd:PRK04863  909 AKRFVQQHGNALAQLEPIVSVLQSDPEQFEQLKQDYQQAQQTQRDAKQQAF--------ALTEVVQRRAHFSYEDAAEML 980

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1698 GEqkvqlQQAQVQELNNRLKKVQDEL-----HLKTIEEQMTHRKMVLFQEESgkfkqsaeEFRKKMEKLMESKviTENDI 1772
Cdd:PRK04863  981 AK-----NSDLNEKLRQRLEQAEQERtrareQLRQAQAQLAQYNQVLASLKS--------SYDAKRQMLQELK--QELQD 1045

                         810       820       830       840       850       860       870
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4502443   1773 SGIRLDFVSLQQENSRAQE-NAKL--CETNIKELERQLQQYREQMQqgqhmeaNHYQKCQKLEDELIAQKREVENLK 1846
Cdd:PRK04863 1046 LGVPADSGAEERARARRDElHARLsaNRSRRNQLEKQLTFCEAEMD-------NLTKKLRKLERDYHEMREQVVNAK 1115
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
1557-1861 5.08e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 41.81  E-value: 5.08e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1557 RLNEELEKSNECAEMLKQKVEELTRQNNETKLMMQRIQAESENIVLEKQTIQQRCEALKIQADGFKDQLRSTNEHLHKQT 1636
Cdd:COG4372   14 SLFGLRPKTGILIAALSEQLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEELEELNEQLQAAQ 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1637 KTEQDFQRKIKCLEEDLAKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQLQQAQVQELNNRL 1716
Cdd:COG4372   94 AELAQAQEELESLQEEAEELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEELAALEQEL 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1717 KKVQDELHLKTIEEQMTHRKMVLFQEESGKFKQSAEEFRKKMEKLMESKVITENDISGIRLDFVSLQQENSRAQENAKLC 1796
Cdd:COG4372  174 QALSEAEAEQALDELLKEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLDALELEEDKEELLE 253

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4502443  1797 ETNIKELERQLQQYREQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQKMDQQIKEHEHQLV 1861
Cdd:COG4372  254 EVILKEIEELELAILVEKDTEEEELEIAALELEALEEAALELKLLALLLNLAALSLIGALEDALL 318
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1266-1722 5.18e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 42.06  E-value: 5.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1266 LEQQKNKLMEELRRKRDNEEEL-LKLIKQMEKDLAfQKQVAEKQLKEKQKIELEARRKITEIQytcrenalpvcpitqat 1344
Cdd:COG4717   47 LLERLEKEADELFKPQGRKPELnLKELKELEEELK-EAEEKEEEYAELQEELEELEEELEELE----------------- 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1345 scRAVTGLQQEHDKQkaeELKQQVDELTAANRKAEQDMRELTYELNALQLEKTSSEE---KARLLKDKLDETNNTL-RCL 1420
Cdd:COG4717  109 --AELEELREELEKL---EKLLQLLPLYQELEALEAELAELPERLEELEERLEELREleeELEELEAELAELQEELeELL 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1421 KLELERKDQAEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEK-------------------G 1481
Cdd:COG4717  184 EQLSLATEEELQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEErlkearlllliaaallallG 263

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1482 KLQREVDRITRAHAVA--------------EKNIQHLNSQIHSFRDEKELERLQicQRKSDHLKEQFEKSHEQLLQNIKA 1547
Cdd:COG4717  264 LGGSLLSLILTIAGVLflvlgllallflllAREKASLGKEAEELQALPALEELE--EEELEELLAALGLPPDLSPEELLE 341

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1548 EKENNDKIQRLNEELEKSNecaemlkqkvEELTRQNNETKL--MMQRIQAESENIVLEKQTIQQRCEALKIQADGFKDQL 1625
Cdd:COG4717  342 LLDRIEELQELLREAEELE----------EELQLEELEQEIaaLLAEAGVEDEEELRAALEQAEEYQELKEELEELEEQL 411

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1626 RSTNEHLHKQ--TKTEQDFQRKIKCLEEDLAKSQNLVSEFKQKCDQQNIIIQN--TKKEVRNLNAELNASKEEKRRGEQK 1701
Cdd:COG4717  412 EELLGELEELleALDEEELEEELEELEEELEELEEELEELREELAELEAELEQleEDGELAELLQELEELKAELRELAEE 491

                        490       500
                 ....*....|....*....|.
gi 4502443  1702 VQLQQAQVQELNNRLKKVQDE 1722
Cdd:COG4717  492 WAALKLALELLEEAREEYREE 512
Tropomyosin pfam00261
Tropomyosin; Tropomyosin is an alpha-helical protein that forms a coiled-coil structure of 2 ...
 1194-1488 7.33e-03

Tropomyosin; Tropomyosin is an alpha-helical protein that forms a coiled-coil structure of 2 parallel helices containing 2 sets of 7 alternating actin binding sites. The protein is best known for its role in regulating the interaction between actin and myosin in muscle contraction, but is also involved in the organization and dynamics of the cytoskeleton in non-muscle cells. There are multiple cell-specific isoforms, expressed by alternative promoters and alternative RNA processing of at least four genes. Muscle isoforms of tropomyosin are characterized by having 284 amino acid residues and a highly conserved N-terminal region, whereas non-muscle forms are generally smaller and are heterogeneous in their N-terminal region.


Pssm-ID: 459736 [Multi-domain]  Cd Length: 235  Bit Score: 40.78  E-value: 7.33e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1194 KQYRRELETIVREKEAAERELERVRQLTIEAEAKRAAveenlLNFRNQLeentftrrtLEDHLKRKdlslNDLEQQKNKL 1273
Cdd:pfam00261    4 QQIKEELDEAEERLKEAMKKLEEAEKRAEKAEAEVAA-----LNRRIQL---------LEEELERT----EERLAEALEK 65

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1274 MEELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEIqytcrenalpvcpitqatscravtglq 1353
Cdd:pfam00261   66 LEEAEKAADESERGRKVLENRALKDEEKMEILEAQLKEAKEIAEEADRKYEEV--------------------------- 118

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1354 qehdkqkAEELKQQVDELTAANRKAEQdmreltyelnalqlektsSEEKARLLKDKLDETNNTLRCLKLELERKDQAEKG 1433
Cdd:pfam00261  119 -------ARKLVVVEGDLERAEERAEL------------------AESKIVELEEELKVVGNNLKSLEASEEKASEREDK 173

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 4502443    1434 YSQQLRELGRQLNQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVD 1488
Cdd:pfam00261  174 YEEQIRFLTEKLKEAETRAEFAERSVQKLEKEVDRLEDELEAEKEKYKAISEELD 228
PLN02939 PLN02939
transferase, transferring glycosyl groups
 1547-1871 8.51e-03

transferase, transferring glycosyl groups


Pssm-ID: 215507 [Multi-domain]  Cd Length: 977  Bit Score: 41.81  E-value: 8.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1547 AEKENNDKIQRLNEELEKSNECAEMLKQKVEELTRQNNEtklMMQRIQAESENIVLEKQTiqqRCEALkiqadgfkdqlr 1626
Cdd:PLN02939   94 DDDHNRASMQRDEAIAAIDNEQQTNSKDGEQLSDFQLED---LVGMIQNAEKNILLLNQA---RLQAL------------ 155

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1627 stnEHLHKQTKTEQDFQRKIKCLEEDLAKSqnlvSEFKQKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQLQQ 1706
Cdd:PLN02939  156 ---EDLEKILTEKEALQGKINILEMRLSET----DARIKLAAQEKIHVEILEEQLEKLRNELLIRGATEGLCVHSLSKEL 228

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1707 AQVQELNNRLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFKQSAEEfrkkmeklMESKVI-TENDISGIrldfVSLQQE 1785
Cdd:PLN02939  229 DVLKEENMLLKDDIQFLKAELIEVAETEERVFKLEKERSLLDASLRE--------LESKFIvAQEDVSKL----SPLQYD 296

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1786 ----------------NSRAQENAKLCETNiKELERQLQQYREQMQQGQHMEANHY------QKCQKLEDELIAQKREVE 1843
Cdd:PLN02939  297 cwwekvenlqdlldraTNQVEKAALVLDQN-QDLRDKVDKLEASLKEANVSKFSSYkvellqQKLKLLEERLQASDHEIH 375

                         330       340
                  ....*....|....*....|....*...
gi 4502443   1844 NLKQKMDQQIKEHEHQLVLLQCEIQKKS 1871
Cdd:PLN02939  376 SYIQLYQESIKEFQDTLSKLKEESKKRS 403
PLEC smart00250
Plectin repeat;
2337-2366 8.61e-03

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 36.31  E-value: 8.61e-03
                            10        20        30
                    ....*....|....*....|....*....|
gi 4502443     2337 HRISVVDTKTGSELTVYEAFQRNLIEKSIY 2366
Cdd:smart00250    9 AIGGIIDPETGQKLSVEEALRRGLIDPETG 38
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
1355-1845 8.63e-03

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 41.56  E-value: 8.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1355 EHDKQKAEELKQQVDELTAANRKAEQDMRELTYELNALQLEKTSSEEKARLLKDKLDETNNTLRCLKLELERKDQAEKGY 1434
Cdd:PRK02224  247 EERREELETLEAEIEDLRETIAETEREREELAEEVRDLRERLEELEEERDDLLAEAGLDDADAEAVEARREELEDRDEEL 326

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1435 SQQLRELGRQLNQTTGKAEEAMQEASDLKKikrnyqlELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFRDE 1514
Cdd:PRK02224  327 RDRLEECRVAAQAHNEEAESLREDADDLEE-------RAEELREEAAELESELEEAREAVEDRREEIEELEEEIEELRER 399

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1515 KEL--ERLQICQRKSDHLKEQFEKSHEQlLQNIKAEKENNDKIQRLNEELEKSNECAEmLKQKVEELTRQN--NETKLMM 1590
Cdd:PRK02224  400 FGDapVDLGNAEDFLEELREERDELRER-EAELEATLRTARERVEEAEALLEAGKCPE-CGQPVEGSPHVEtiEEDRERV 477

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1591 QRIQAESENIVLEKQTIQQRCEALKiqadgfkdqlrstnehlhKQTKTEQDFQRkikcLEEDLAKSQNLVSEFKQKCDQQ 1670
Cdd:PRK02224  478 EELEAELEDLEEEVEEVEERLERAE------------------DLVEAEDRIER----LEERREDLEELIAERRETIEEK 535

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1671 NIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQLQQAQVQELNNRLKKVQDELH-LKTIEEQMTHR-----KMVLFQEES 1744
Cdd:PRK02224  536 RERAEELRERAAELEAEAEEKREAAAEAEEEAEEAREEVAELNSKLAELKERIEsLERIRTLLAAIadaedEIERLREKR 615

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1745 GKFKQSAEEFRKKMEKLMESKVITENDISGIRLDfvSLQQENSRAQENAKLCETNIKELERQlqqyREQMQQGQHMEANH 1824
Cdd:PRK02224  616 EALAELNDERRERLAEKRERKRELEAEFDEARIE--EAREDKERAEEYLEQVEEKLDELREE----RDDLQAEIGAVENE 689

                         490       500
                  ....*....|....*....|.
gi 4502443   1825 YQKCQKLEDELIAQKREVENL 1845
Cdd:PRK02224  690 LEELEELRERREALENRVEAL 710
ClpA COG0542
ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein ...
 1471-1591 8.69e-03

ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440308 [Multi-domain]  Cd Length: 836  Bit Score: 41.61  E-value: 8.69e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443  1471 LELESLNHEKGKLQREVDRITRAHAVAEKNiqhlnsqihsfRDEKELERLQICQRKSDHLKEQFEksheQLLQNIKAEKE 1550
Cdd:COG0542  404 MEIDSKPEELDELERRLEQLEIEKEALKKE-----------QDEASFERLAELRDELAELEEELE----ALKARWEAEKE 468

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 4502443  1551 NNDKIQRLNEELEKSNECAEMLKQKVEELTRQNNETKLMMQ 1591
Cdd:COG0542  469 LIEEIQELKEELEQRYGKIPELEKELAELEEELAELAPLLR 509
PRK10929 PRK10929
putative mechanosensitive channel protein; Provisional
 1361-1697 8.71e-03

putative mechanosensitive channel protein; Provisional


Pssm-ID: 236798 [Multi-domain]  Cd Length: 1109  Bit Score: 41.58  E-value: 8.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1361 AEELKQQVDELTAANRKAEQD-MRELTYELNALQlEKTSSEEKARLLKDKLDETNNTLRCLKLELERKDQAEKGY----- 1434
Cdd:PRK10929   25 EKQITQELEQAKAAKTPAQAEiVEALQSALNWLE-ERKGSLERAKQYQQVIDNFPKLSAELRQQLNNERDEPRSVppnms 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1435 -----------SQQLRELGRQLNQTTGKAEEAM-------QEASDLKKIKRNYQLELESLNHEKGKLQREVDRITRAHAV 1496
Cdd:PRK10929  104 tdaleqeilqvSSQLLEKSRQAQQEQDRAREISdslsqlpQQQTEARRQLNEIERRLQTLGTPNTPLAQAQLTALQAESA 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1497 AEK-NIQHLNSQIHSFRDEKELERLQIcqrksdhlkEQFEKSHEQLLQNIKAEKeNNDKIQRlNEELEKSNECAEMLKQK 1575
Cdd:PRK10929  184 ALKaLVDELELAQLSANNRQELARLRS---------ELAKKRSQQLDAYLQALR-NQLNSQR-QREAERALESTELLAEQ 252

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1576 VEELT-------RQNNETKLMMQRiQAESENIVLEKQ------TIQQR-------------------CEALKIQA----- 1618
Cdd:PRK10929  253 SGDLPksivaqfKINRELSQALNQ-QAQRMDLIASQQrqaasqTLQVRqalntlreqsqwlgvsnalGEALRAQVarlpe 331

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443   1619 -------DGFKDQLRSTN-------EHLHKQTKTEQDF-------QRKIkcLEEDLAKSQNLVSEFKQKCDQQniIIQNT 1677
Cdd:PRK10929  332 mpkpqqlDTEMAQLRVQRlryedllNKQPQLRQIRQADgqpltaeQNRI--LDAQLRTQRELLNSLLSGGDTL--ILELT 407

                         410       420
                  ....*....|....*....|..
gi 4502443   1678 KKEVRN--LNAELNASKEEKRR 1697
Cdd:PRK10929  408 KLKVANsqLEDALKEVNEATHR 429
DUF4670 pfam15709
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ...
 1205-1405 8.84e-03

Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.


Pssm-ID: 464815 [Multi-domain]  Cd Length: 522  Bit Score: 41.48  E-value: 8.84e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1205 REKEAAEREL---ERVRQLTIEAEAKRAAVEENllnfrnqleentftRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKR 1281
Cdd:pfam15709  328 REQEKASRDRlraERAEMRRLEVERKRREQEEQ--------------RRLQQEQLERAEKMREELELEQQRRFEEIRLRK 393

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502443    1282 DNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKielEARRKITEIQYTcrenalpvcpitqatscravtglQQEHDKQKA 1361
Cdd:pfam15709  394 QRLEEERQRQEEEERKQRLQLQAAQERARQQQE---EFRRKLQELQRK-----------------------KQQEEAERA 447

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*..
gi 4502443    1362 EELKQQVDELT---AANRKAEQDMREltYELNALQLEKTSSEEKARL 1405
Cdd:pfam15709  448 EAEKQRQKELEmqlAEEQKRLMEMAE--EERLEYQRQKQEAEEKARL 492
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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