corticotropin-releasing factor-binding protein [Homo sapiens]
Protein Classification
CRF-BP domain-containing protein( domain architecture ID 10527118)
CRF-BP domain-containing protein
List of domain hits
| Name | Accession | Description | Interval | E-value | |||||
| CRF-BP | pfam05428 | Corticotropin-releasing factor binding protein (CRF-BP); This family consists of several ... |
10-307 | 0e+00 | |||||
Corticotropin-releasing factor binding protein (CRF-BP); This family consists of several eukaryotic corticotropin-releasing factor binding proteins (CRF-BP or CRH-BP). Corticotropin-releasing hormone (CRH) plays multiple roles in vertebrate species. In mammals, it is the major hypothalamic releasing factor for pituitary adrenocorticotropin secretion, and is a neurotransmitter or neuromodulator at other sites in the central nervous system. In non-mammalian vertebrates, CRH not only acts as a neurotransmitter and hypophysiotropin, it also acts as a potent thyrotropin-releasing factor, allowing CRH to regulate both the adrenal and thyroid axes, especially in development. CRH-BP is thought to play an inhibitory role in which it binds CRH and other CRH-like ligands and prevents the activation of CRH receptors. There is however evidence that CRH-BP may also exhibit diverse extra and intracellular roles in a cell specific fashion and at specific times in development. : Pssm-ID: 461650 Cd Length: 298 Bit Score: 647.16 E-value: 0e+00
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| Name | Accession | Description | Interval | E-value | |||||
| CRF-BP | pfam05428 | Corticotropin-releasing factor binding protein (CRF-BP); This family consists of several ... |
10-307 | 0e+00 | |||||
Corticotropin-releasing factor binding protein (CRF-BP); This family consists of several eukaryotic corticotropin-releasing factor binding proteins (CRF-BP or CRH-BP). Corticotropin-releasing hormone (CRH) plays multiple roles in vertebrate species. In mammals, it is the major hypothalamic releasing factor for pituitary adrenocorticotropin secretion, and is a neurotransmitter or neuromodulator at other sites in the central nervous system. In non-mammalian vertebrates, CRH not only acts as a neurotransmitter and hypophysiotropin, it also acts as a potent thyrotropin-releasing factor, allowing CRH to regulate both the adrenal and thyroid axes, especially in development. CRH-BP is thought to play an inhibitory role in which it binds CRH and other CRH-like ligands and prevents the activation of CRH receptors. There is however evidence that CRH-BP may also exhibit diverse extra and intracellular roles in a cell specific fashion and at specific times in development. Pssm-ID: 461650 Cd Length: 298 Bit Score: 647.16 E-value: 0e+00
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| Name | Accession | Description | Interval | E-value | |||||
| CRF-BP | pfam05428 | Corticotropin-releasing factor binding protein (CRF-BP); This family consists of several ... |
10-307 | 0e+00 | |||||
Corticotropin-releasing factor binding protein (CRF-BP); This family consists of several eukaryotic corticotropin-releasing factor binding proteins (CRF-BP or CRH-BP). Corticotropin-releasing hormone (CRH) plays multiple roles in vertebrate species. In mammals, it is the major hypothalamic releasing factor for pituitary adrenocorticotropin secretion, and is a neurotransmitter or neuromodulator at other sites in the central nervous system. In non-mammalian vertebrates, CRH not only acts as a neurotransmitter and hypophysiotropin, it also acts as a potent thyrotropin-releasing factor, allowing CRH to regulate both the adrenal and thyroid axes, especially in development. CRH-BP is thought to play an inhibitory role in which it binds CRH and other CRH-like ligands and prevents the activation of CRH receptors. There is however evidence that CRH-BP may also exhibit diverse extra and intracellular roles in a cell specific fashion and at specific times in development. Pssm-ID: 461650 Cd Length: 298 Bit Score: 647.16 E-value: 0e+00
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