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Conserved domains on  [gi|31317299|ref|NP_002156|]
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DNA-binding protein inhibitor ID-1 isoform a [Homo sapiens]

Protein Classification

DNA-binding protein inhibitor ID-1( domain architecture ID 14444556)

DNA-binding protein inhibitor ID-1 acts as transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity

Gene Ontology:  GO:0140416|GO:0045892|GO:0046983

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
bHLH_dnHLH_ID1 cd19691
basic helix-loop-helix (bHLH) domain found in DNA-binding protein inhibitor ID1 and similar ...
62-113 5.28e-32

basic helix-loop-helix (bHLH) domain found in DNA-binding protein inhibitor ID1 and similar proteins; ID1, also termed Class B basic helix-loop-helix protein 24 (bHLHb24), or inhibitor of DNA binding 1, or inhibitor of differentiation 1, is a dominant negative helix-loop-helix (dnHLH) transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the bHLH transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. ID1 interferes with centrosomal function. It has been implicated in the regulation of cell proliferation and differentiation in myogenesis, neurogenesis, and/or hematopoiesis.


:

Pssm-ID: 381534  Cd Length: 52  Bit Score: 108.35  E-value: 5.28e-32
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 31317299  62 VNVLLYDMNGCYSRLKELVPTLPQNRKVSKVEILQHVIDYIRDLQLELNSES 113
Cdd:cd19691   1 MNMLLYDMNGCYSRLKELVPTLPQNRKVSKVEILQHVIDYIWDLQVELDSGP 52
 
Name Accession Description Interval E-value
bHLH_dnHLH_ID1 cd19691
basic helix-loop-helix (bHLH) domain found in DNA-binding protein inhibitor ID1 and similar ...
62-113 5.28e-32

basic helix-loop-helix (bHLH) domain found in DNA-binding protein inhibitor ID1 and similar proteins; ID1, also termed Class B basic helix-loop-helix protein 24 (bHLHb24), or inhibitor of DNA binding 1, or inhibitor of differentiation 1, is a dominant negative helix-loop-helix (dnHLH) transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the bHLH transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. ID1 interferes with centrosomal function. It has been implicated in the regulation of cell proliferation and differentiation in myogenesis, neurogenesis, and/or hematopoiesis.


Pssm-ID: 381534  Cd Length: 52  Bit Score: 108.35  E-value: 5.28e-32
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 31317299  62 VNVLLYDMNGCYSRLKELVPTLPQNRKVSKVEILQHVIDYIRDLQLELNSES 113
Cdd:cd19691   1 MNMLLYDMNGCYSRLKELVPTLPQNRKVSKVEILQHVIDYIWDLQVELDSGP 52
HLH pfam00010
Helix-loop-helix DNA-binding domain;
67-106 1.97e-16

Helix-loop-helix DNA-binding domain;


Pssm-ID: 459628 [Multi-domain]  Cd Length: 53  Bit Score: 68.64  E-value: 1.97e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 31317299    67 YDMNGCYSRLKELVPTLPQNRKVSKVEILQHVIDYIRDLQ 106
Cdd:pfam00010  14 DRINDAFDELRELLPTLPPDKKLSKAEILRLAIEYIKHLQ 53
HLH smart00353
helix loop helix domain;
68-109 6.88e-15

helix loop helix domain;


Pssm-ID: 197674 [Multi-domain]  Cd Length: 53  Bit Score: 64.55  E-value: 6.88e-15
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 31317299     68 DMNGCYSRLKELVPTLPQNRKVSKVEILQHVIDYIRDLQLEL 109
Cdd:smart00353  10 KINEAFDELRSLLPTLPKNKKLSKAEILRLAIEYIKSLQEEL 51
 
Name Accession Description Interval E-value
bHLH_dnHLH_ID1 cd19691
basic helix-loop-helix (bHLH) domain found in DNA-binding protein inhibitor ID1 and similar ...
62-113 5.28e-32

basic helix-loop-helix (bHLH) domain found in DNA-binding protein inhibitor ID1 and similar proteins; ID1, also termed Class B basic helix-loop-helix protein 24 (bHLHb24), or inhibitor of DNA binding 1, or inhibitor of differentiation 1, is a dominant negative helix-loop-helix (dnHLH) transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the bHLH transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. ID1 interferes with centrosomal function. It has been implicated in the regulation of cell proliferation and differentiation in myogenesis, neurogenesis, and/or hematopoiesis.


Pssm-ID: 381534  Cd Length: 52  Bit Score: 108.35  E-value: 5.28e-32
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 31317299  62 VNVLLYDMNGCYSRLKELVPTLPQNRKVSKVEILQHVIDYIRDLQLELNSES 113
Cdd:cd19691   1 MNMLLYDMNGCYSRLKELVPTLPQNRKVSKVEILQHVIDYIWDLQVELDSGP 52
bHLH_dnHLH_ID cd19684
basic helix-loop-helix (bHLH) domain found in the DNA-binding protein inhibitor (ID) family; ...
63-108 8.96e-29

basic helix-loop-helix (bHLH) domain found in the DNA-binding protein inhibitor (ID) family; The ID family includes a dominant negative group of helix-loop-helix (dnHLH) proteins, ID1-4, that are negative regulators of bHLH transcription factors. They contain the HLH-dimerization domain but lack the basic domain necessary for DNA-binding. ID proteins inhibit binding to DNA and transcriptional transactivation by heterodimerization with bHLH proteins. They also interact with many non-bHLH proteins in complex networks. ID proteins have been implicated in regulating gene expression as well as cell-cycle progression. Whereas ID-1, ID-2 and ID-3, are generally considered as tumor promoters, ID4 on the contrary has emerged as a tumor suppressor.


Pssm-ID: 381527  Cd Length: 47  Bit Score: 100.04  E-value: 8.96e-29
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 31317299  63 NVLLYDMNGCYSRLKELVPTLPQNRKVSKVEILQHVIDYIRDLQLE 108
Cdd:cd19684   2 DILNAEMQDCYSKLKELVPTIPQNKKVSKVEILQHVIDYILDLQLA 47
bHLH_dnHLH_ID2 cd19692
basic helix-loop-helix (bHLH) domain found in DNA-binding protein inhibitor ID2 and similar ...
65-113 4.84e-25

basic helix-loop-helix (bHLH) domain found in DNA-binding protein inhibitor ID2 and similar proteins; ID2, also termed Class B basic helix-loop-helix protein 26 (bHLHb26), or inhibitor of DNA binding 2, or inhibitor of differentiation 2, is a dominant negative helix-loop-helix (dnHLH) transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the bHLH transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. It has been implicated in the regulation of cell proliferation and differentiation in myogenesis, neurogenesis, and/or hematopoiesis.


Pssm-ID: 381535  Cd Length: 66  Bit Score: 91.23  E-value: 4.84e-25
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 31317299  65 LLYDMNGCYSRLKELVPTLPQNRKVSKVEILQHVIDYIRDLQLELNSES 113
Cdd:cd19692  18 LLYNMNDCYSKLKELVPSIPQNKKVSKMEILQHVIDYILDLQIALDSHP 66
bHLH_dnHLH_ID4 cd19694
basic helix-loop-helix (bHLH) domain found in DNA-binding protein inhibitor ID4 and similar ...
59-111 3.46e-24

basic helix-loop-helix (bHLH) domain found in DNA-binding protein inhibitor ID4 and similar proteins; ID4, also termed Class B basic helix-loop-helix protein 27 (bHLHb27), or inhibitor of DNA binding 4, or inhibitor of differentiation 4, is a dominant negative helix-loop-helix (dnHLH) transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the bHLH transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. It plays a role in adipose cell differentiation.


Pssm-ID: 381537  Cd Length: 60  Bit Score: 88.92  E-value: 3.46e-24
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 31317299  59 EQQVNVLLYDMNGCYSRLKELVPTLPQNRKVSKVEILQHVIDYIRDLQLELNS 111
Cdd:cd19694   1 EEEALCLQYDMNDCYSRLKRLVPTIPPNKKVSKVEILQHVIDYILDLQLALET 53
bHLH_dnHLH_ID3 cd19693
basic helix-loop-helix (bHLH) domain found in DNA-binding protein inhibitor ID3 and similar ...
65-108 2.04e-22

basic helix-loop-helix (bHLH) domain found in DNA-binding protein inhibitor ID3 and similar proteins; ID3, also termed Class B basic helix-loop-helix protein 25 (bHLHb25), or helix-loop-helix protein HEIR-1, or ID-like protein inhibitor HLH 1R21, or inhibitor of DNA binding 3, or inhibitor of differentiation 3, is a dominant negative helix-loop-helix (dnHLH) transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the bHLH transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. It negatively regulates muscle differentiation by inhibiting the DNA-binding activities of the myogenic regulatory factors.


Pssm-ID: 381536  Cd Length: 61  Bit Score: 84.06  E-value: 2.04e-22
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 31317299  65 LLYDMNGCYSRLKELVPTLPQNRKVSKVEILQHVIDYIRDLQLE 108
Cdd:cd19693  18 LLYDMNDCYSRLRELVPGVPQGTKLSQVEILQHVIDYILDLQIV 61
bHLH_dnHLH_EMC_like cd19695
basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster protein ...
57-111 9.45e-18

basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster protein extra-macrochaetae and similar proteins; Extra-macrochaetae is a negative regulator of sensory organ development in Drosophila. It belongs to dominant negative group of helix-loop-helix (dnHLH) proteins, which lack a basic DNA-binding domain but can form heterodimers with other HLH proteins, thereby inhibiting DNA binding.


Pssm-ID: 381538  Cd Length: 52  Bit Score: 72.02  E-value: 9.45e-18
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 31317299  57 LDEQQVNVLLYdmngcYSRLKELVPTLPQNRKVSKVEILQHVIDYIRDLQLELNS 111
Cdd:cd19695   1 LNQERREMALY-----LAKLRNLVPTLPKNRKVSKLELLQHVIDYIADLEEQLED 50
HLH pfam00010
Helix-loop-helix DNA-binding domain;
67-106 1.97e-16

Helix-loop-helix DNA-binding domain;


Pssm-ID: 459628 [Multi-domain]  Cd Length: 53  Bit Score: 68.64  E-value: 1.97e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 31317299    67 YDMNGCYSRLKELVPTLPQNRKVSKVEILQHVIDYIRDLQ 106
Cdd:pfam00010  14 DRINDAFDELRELLPTLPPDKKLSKAEILRLAIEYIKHLQ 53
HLH smart00353
helix loop helix domain;
68-109 6.88e-15

helix loop helix domain;


Pssm-ID: 197674 [Multi-domain]  Cd Length: 53  Bit Score: 64.55  E-value: 6.88e-15
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 31317299     68 DMNGCYSRLKELVPTLPQNRKVSKVEILQHVIDYIRDLQLEL 109
Cdd:smart00353  10 KINEAFDELRSLLPTLPKNKKLSKAEILRLAIEYIKSLQEEL 51
bHLH_SF cd00083
basic Helix Loop Helix (bHLH) domain superfamily; bHLH proteins are transcriptional regulators ...
69-106 1.30e-13

basic Helix Loop Helix (bHLH) domain superfamily; bHLH proteins are transcriptional regulators that are found in organisms from yeast to humans. Members of the bHLH superfamily have two highly conserved and functionally distinct regions. The basic part is at the amino end of the bHLH that may bind DNA to a consensus hexanucleotide sequence known as the E box (CANNTG). Different families of bHLH proteins recognize different E-box consensus sequences. At the carboxyl-terminal end of the region is the HLH region that interacts with other proteins to form homo- and heterodimers. bHLH proteins function as a diverse set of regulatory factors because they recognize different DNA sequences and dimerize with different proteins. The bHLH proteins can be divided to cell-type specific and widely expressed proteins. The cell-type specific members of bHLH superfamily are involved in cell-fate determination and act in neurogenesis, cardiogenesis, myogenesis, and hematopoiesis.


Pssm-ID: 381392 [Multi-domain]  Cd Length: 46  Bit Score: 61.38  E-value: 1.30e-13
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 31317299  69 MNGCYSRLKELVPTLPQNRKVSKVEILQHVIDYIRDLQ 106
Cdd:cd00083   8 INDAFEELKRLLPELPDSKKLSKASILQKAVEYIRELQ 45
bHLH_TS_ASCL cd11418
basic helix-loop-helix (bHLH) domain found in achaete-scute complex-like (ASCL) family; The ...
70-109 2.64e-10

basic helix-loop-helix (bHLH) domain found in achaete-scute complex-like (ASCL) family; The achaete-scute complex-like (ASCL, also known as achaete-scute complex homolog or ASH) family of bHLH transcription factors, ASCL1-5, have been implicated in cell fate specification and differentiation. They are critical for proper development of the nervous system. The deregulation of ASCL plays a key role in psychiatric and neurological disorders. ASCL-1, also termed Class A basic helix-loop-helix protein 46 (bHLHa46), or achaete-scute homolog 1 (ASH-1), or mammalian achaete-scute homolog 1 (Mash1), is a neural-specific bHLH transcription factor that is expressed in subsets of neural progenitors in both the central and peripheral nervous system. It plays a key role in neuronal differentiation and specification in the nervous system. ASCL-2, also termed achaete-scute homolog 2 (ASH-2), or Class A basic helix-loop-helix protein 45 (bHLHa45), or mammalian achaete-scute homolog 2 (Mash2), is a bHLH transcription factor that is involved in Schwann cell differentiation and control of proliferation in adult peripheral nerves. ASCL-3, also termed Class A basic helix-loop-helix protein 42 (bHLHa42), or bHLH transcriptional regulator Sgn-1, or achaete-scute homolog 3 (ASH-3), is a bHLH transcription factor specifically localized in the duct cells of the salivary glands. It may act as transcriptional repressor that inhibits myogenesis. The family also includes Drosophila melanogaster achaete-scute complex (AS-C) proteins, which consists of lethal of scute (also known as achaete-scute complex protein T3 or AST3), scute (also known as achaete-scute complex protein T4 or AST4), achaete (also known as achaete-scute complex protein T5 or AST5), and asense (also known as achaete-scute complex protein T8 or AST8). They are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system, as well as in sex determination and dosage compensation.


Pssm-ID: 381424 [Multi-domain]  Cd Length: 56  Bit Score: 52.99  E-value: 2.64e-10
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 31317299  70 NGCYSRLKELVPTLPQNRKVSKVEILQHVIDYIRDLQLEL 109
Cdd:cd11418  17 NDAFDRLRQHVPYLKRRKKLSKVKTLRRAIEYIRHLQKLL 56
bHLH_TS_FIGLA cd11422
basic helix-loop-helix (bHLH) domain found in factor in the germline alpha (FIGLA) and similar ...
69-110 5.07e-10

basic helix-loop-helix (bHLH) domain found in factor in the germline alpha (FIGLA) and similar proteins; FIGLA, also termed FIGalpha, or Class C basic helix-loop-helix protein 8 (bHLHc8), or folliculogenesis-specific basic helix-loop-helix protein, or transcription factor FIGa, is a germ-cell-specific bHLH transcription factor expressed abundantly in female and less so in male germ cells. It is essential for primordial follicle formation and expression of many genes required for folliculogenesis, fertilization and early embryonic survival. FIGLA knockout mice cannot form primordial follicles and lose oocytes rapidly after birth, whereas male gonads are unaffected.


Pssm-ID: 381428  Cd Length: 56  Bit Score: 52.36  E-value: 5.07e-10
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 31317299  69 MNGCYSRLKELVPTLPQNRKVSKVEILQHVIDYIRDLQLELN 110
Cdd:cd11422  15 LNSGFSKLRRIVPLIPRDRKPSKVDTLKGATEYIRLLQRILE 56
bHLH_AtPRE_like cd11442
basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana paclobutrazol resistance ...
69-114 7.05e-09

basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana paclobutrazol resistance (PRE) family; The PRE family includes several bHLH transcription factors from Arabidopsis thaliana, such as PRE1-6. PRE1 (also termed AtbHLH136, or protein banquo 1), PRE2 (also termed AtbHLH134, or protein banquo 2, or EN 52), PRE4 (also termed AtbHLH161, or protein banquo 3), and PRE5 (also termed AtbHLH164) are atypical and probable non DNA-binding bHLH transcription factors that integrate multiple signaling pathways to regulate cell elongation and plant development. PRE3 (also termed AtbHLH135, or protein activation-tagged BRI1 suppressor 1, or ATBS1, or protein target of MOOPTEROS 7, or EN 67) is an atypical and probable non DNA-binding bHLH transcription factor required for MONOPTEROS-dependent root initiation in embryo. It promotes the correct definition of the hypophysis cell division plane. PRE5 (also termed AtbHLH163, or protein KIDARI) is an atypical and probable non DNA-binding bHLH transcription factor that regulates light-mediated responses in day light conditions by binding and inhibiting the activity of the bHLH transcription factor HFR1, a critical regulator of light signaling and shade avoidance.


Pssm-ID: 381448  Cd Length: 65  Bit Score: 49.61  E-value: 7.05e-09
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 31317299  69 MNGCYSRLKELVPTLPQNRKVSKVEILQHVIDYIRDLQLELNSESE 114
Cdd:cd11442  12 KNDLYSRLRALLPSIATSDKVSKATVLEEACNYIRNLHREVDDLSE 57
bHLH_TS cd11390
tissue specific basic helix-loop-helix (bHLH-TS) domain family; Tissue specific bHLH domain ...
68-106 1.11e-08

tissue specific basic helix-loop-helix (bHLH-TS) domain family; Tissue specific bHLH domain family includes transcription regulators whose expression are restricted to certain tissues. They are involved in cell-fate determination and process in neurogenesis, cardiogenesis, myogenesis, and hematopoiesis and include proteins from myogenic regulatory factor (MRF) family, twist-related protein (TWIST) family, scleraxis-like family, heart- and neural crest derivatives-expressed protein (HAND) family, helix-loop-helix protein (HEN) family, musculin-like family, germline alpha (FIGLA) family, T-cell acute lymphocytic leukemia protein/ lymphoblastic leukemia-derived sequence (TAL/LYL) family, ovary, uterus and testis protein (OUT) family, mesoderm posterior protein (Mesp) family, muscle, intestine and stomach expression 1 (MIST-1) family, protein atonal homologs (ATOH) family, neurogenin (NGN) family, neurogenic differentiation factor (NeuroD) family, achaete-scute complex-like (ASCL) family, Fer3-like protein (FERD3L)-like family, and Oligodendrocyte lineage genes (OLIG) family of transcription factors.


Pssm-ID: 381396 [Multi-domain]  Cd Length: 55  Bit Score: 48.72  E-value: 1.11e-08
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 31317299  68 DMNGCYSRLKELVPTLPQNRKVSKVEILQHVIDYIRDLQ 106
Cdd:cd11390  14 DLNDAFEALRKVLPTVPPDKKLSKIETLRLAINYIAALS 52
bHLH_TS_ASCL1_like cd19723
basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster achaete-scute complex ...
70-109 1.17e-07

basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster achaete-scute complex (AS-C) proteins, achaete-scute-like proteins, ASCL1-2, and similar proteins; This subfamily includes Drosophila melanogaster AS-C proteins and two ASCL family of transcription factors, ASCL-1 and ASCL-2. Drosophila melanogaster AS-C proteins includes lethal of scute (also known as achaete-scute complex protein T3 or AST3), scute (also known as achaete-scute complex protein T4 or AST4), achaete (also known as achaete-scute complex protein T5 or AST5), and asense (also known as achaete-scute complex protein T8 or AST8). They are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system, as well as in sex determination and dosage compensation. ASCL-1, also termed Class A basic helix-loop-helix protein 46 (bHLHa46), or achaete-scute homolog 1 (ASH-1), or mammalian achaete scute homolog 1 (Mash1), is expressed in subsets of neural progenitors in both the central and peripheral nervous system. It plays a key role in neuronal differentiation and specification in the nervous system. ASCL-2, also termed achaete-scute homolog 2 (ASH-2), or Class A basic helix-loop-helix protein 45 (bHLHa45), or mammalian achaete scute homolog 2 (Mash2), is involved in Schwann cell differentiation and control of proliferation in adult peripheral nerves.


Pssm-ID: 381566  Cd Length: 56  Bit Score: 45.90  E-value: 1.17e-07
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 31317299  70 NGCYSRLKELVPTLPQNRKVSKVEILQHVIDYIRDLQLEL 109
Cdd:cd19723  17 NLGFATLREHVPNGRANKKMSKVETLRSAVEYIRQLQQLL 56
bHLH_TS_dHLH3B_like cd19708
basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster helix loop helix protein ...
68-105 3.20e-07

basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster helix loop helix protein 3B (dHLH3B) and similar proteins; Drosophila HLH3B is an uncharacterized bHLH transcription factor that belongs to the T-cell acute lymphocytic leukemia protein/ lymphoblastic leukemia-derived sequence (TAL/LYL) family.


Pssm-ID: 381551 [Multi-domain]  Cd Length: 60  Bit Score: 44.88  E-value: 3.20e-07
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 31317299  68 DMNGCYSRLKELVPTLPQNRKVSKVEILQHVIDYIRDL 105
Cdd:cd19708  15 NVNGAFAELRKLVPTHPPDKKLSKNEILRLAIKYIRLL 52
bHLHzip_Myc cd11400
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in the Myc family; The Myc family is a ...
68-114 7.08e-07

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in the Myc family; The Myc family is a member of the bHLHzip family of transcription factors that play important roles in the control of normal cell proliferation, growth, survival and differentiation. All Myc isoforms contain two independently functioning polypeptide chain regions: N-terminal transactivating residues and a C-terminal bHLHzip segment. The bHLHzip family of bHLH transcription factors are characterized by a highly conserved N-terminal basic region that may bind DNA at a consensus hexanucleotide sequence known as the E-box (CANNTG) followed by HLH and leucine zipper motifs that may interact with other proteins to form homo- and heterodimers. Myc heterodimerizes with Max enabling specific binding to E-box DNA sequences in the promoters of target genes. The Myc proto-oncoprotein family includes at least five different functional members: c-, N-, L-, S- and B-Myc (which is lacking the bHLH domain).


Pssm-ID: 381406 [Multi-domain]  Cd Length: 80  Bit Score: 44.46  E-value: 7.08e-07
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 31317299  68 DMNGCYSRLKELVPTLPQNRKVSKVEILQHVIDYIRDLQ---LELNSESE 114
Cdd:cd11400  15 DLKNSFEKLRDLVPELADNEKASKVVILKKATEYIKQLQqeeKKLEKEKD 64
bHLH_TS_TAL_LYL cd11413
basic helix-loop-helix (bHLH) domain found in T-cell acute lymphocytic leukemia protein/ ...
60-106 3.48e-06

basic helix-loop-helix (bHLH) domain found in T-cell acute lymphocytic leukemia protein/ lymphoblastic leukemia-derived sequence (TAL/LYL) family; The TAL/LYL family includes a group of bHLH transcription factors (TAL1, TAL2 and LYL1) implicated in T cell acute leukaemia. They act as mediators of T cell leukaemogenesis. TAL-1, also termed Class A basic helix-loop-helix protein 17 (bHLHa17), or stem cell protein (SCL), or T-cell leukemia/lymphoma protein 5, is a hematopoietic-specific bHLH transcription factor that functions in embryonic and adult hematopoiesis in vertebrates. It is also required for embryonic vascular remodeling. It acts as a regulator of erythroid differentiation and binds to regulatory regions of a large cohort of erythroid genes as part of a complex with GATA-1, LMO2 and Ldb1. TAL-2, also termed Class A basic helix-loop-helix protein 19 (bHLHa19), is a bHLH transcription factor essential for the normal brain development. Lyl-1, also termed Class A basic helix-loop-helix protein 18 (bHLHa18), or lymphoblastic leukemia-derived sequence 1, is a proto-oncogenic bHLH transcription factor that plays an important role in hematopoietic stem cell function and is required for the late stages of postnatal angiogenesis to limit the formation of new blood vessels, notably by regulating the activity of the small GTPase Rap1. LYL-1 deficiency induces a stress erythropoiesis.


Pssm-ID: 381419 [Multi-domain]  Cd Length: 60  Bit Score: 42.05  E-value: 3.48e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
gi 31317299  60 QQVNVllydmNGCYSRLKELVPTLPQNRKVSKVEILQHVIDYIRDLQ 106
Cdd:cd11413  12 RQQNV-----NGAFAELRKLIPTHPPDKKLSKNEILRLAMKYIKFLE 53
bHLH_TS_TAL1 cd19706
basic helix-loop-helix (bHLH) domain found in T-cell acute lymphocytic leukemia protein 1 ...
68-114 5.61e-06

basic helix-loop-helix (bHLH) domain found in T-cell acute lymphocytic leukemia protein 1 (TAL-1) and similar proteins; TAL-1, also termed Class A basic helix-loop-helix protein 17 (bHLHa17), or stem cell protein (SCL), or T-cell leukemia/lymphoma protein 5, is a hematopoietic-specific bHLH transcription factor that functions in embryonic and adult hematopoiesis in vertebrates. It is also required for embryonic vascular remodeling. It acts as a regulator of erythroid differentiation and binds to regulatory regions of a large cohort of erythroid genes as part of a complex with GATA-1, LMO2 and Ldb1. TAL-1 has been implicated in T-cell acute lymphoblastic leukemia. In common with other tissue-specific bHLH proteins, Tal heterodimerizes with ubiquitously-expressed members of the E2A family and form a DNA-binding complex with an E-box (CANNTG) to regulate transcription at its recognition site.


Pssm-ID: 381549 [Multi-domain]  Cd Length: 65  Bit Score: 41.95  E-value: 5.61e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
gi 31317299  68 DMNGCYSRLKELVPTLPQNRKVSKVEILQHVIDYIRDLQLELNSESE 114
Cdd:cd19706  18 NVNGAFAELRKLIPTHPPDKKLSKNEILRLAMKYINFLAKLLNDQEE 64
bHLH_TS_HEN cd11414
basic helix-loop-helix (bHLH) domain found in helix-loop-helix protein (HEN) family; The HEN ...
70-102 8.60e-06

basic helix-loop-helix (bHLH) domain found in helix-loop-helix protein (HEN) family; The HEN family includes two neuron-specific bHLH transcription factors, HEN-1 (also known as Nhlh1 or bHLHa35 or NSCL-1) and HEN-2 (also known as Nhlh2 or bHLHa34 or NSCL-2). They may serve as DNA-binding protein that is involved in the control of cell-type determination, possibly within the developing nervous system.


Pssm-ID: 381420  Cd Length: 57  Bit Score: 40.97  E-value: 8.60e-06
                        10        20        30
                ....*....|....*....|....*....|...
gi 31317299  70 NGCYSRLKELVPTLPQNRKVSKVEILQHVIDYI 102
Cdd:cd11414  18 NSAFAQLRKLLPTLPPDKKLSKIEILRLAICYI 50
bHLH_TS_LYL1 cd19705
basic helix-loop-helix (bHLH) domain found in protein lyl-1 and similar proteins; Lyl-1, also ...
68-113 1.48e-05

basic helix-loop-helix (bHLH) domain found in protein lyl-1 and similar proteins; Lyl-1, also termed Class A basic helix-loop-helix protein 18 (bHLHa18), or lymphoblastic leukemia-derived sequence 1, is a proto-oncogenic bHLH transcription factor involved in T-cell acute lymphoblastic leukemia. It plays an important role in hematopoietic stem cell function and is required for the late stages of postnatal angiogenesis to limit the formation of new blood vessels, notably by regulating the activity of the small GTPase Rap1. LYL-1 deficiency induces a stress erythropoiesis.


Pssm-ID: 381548 [Multi-domain]  Cd Length: 65  Bit Score: 40.77  E-value: 1.48e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 31317299  68 DMNGCYSRLKELVPTLPQNRKVSKVEILQHVIDYIRDLQLELNSES 113
Cdd:cd19705  20 NVNGAFAELRKLIPTHPPDKKLSKNEILRLAMKYIDFLVTLLRDQA 65
bHLH-O_HERP_HES cd19685
basic helix-loop-helix-orange (bHLH-O) domain found in HERP/HES-like family; The HERP/HES-like ...
69-109 1.64e-05

basic helix-loop-helix-orange (bHLH-O) domain found in HERP/HES-like family; The HERP/HES-like family includes bHLH-O transcriptional regulators that are related to the Drosophila hairy and Enhancer-of-split (HES) proteins. The HERP (HES-related repressor protein) subfamily proteins contain a basic helix-loop-helix (bHLH) domain with an invariant glycine residue in its basic region, an orange domain in the central region and YXXW sequence motif at its C-terminal region. Hairy and enhancer of split (HES)-related repressor protein (HERP) proteins (HEY1, HEY2 and HEYL) act as downstream effectors of Notch signaling. They are involved in cardiovascular development and have roles in somitogenesis, myogenesis and gliogenesis. Hairy and enhancer of split-related protein HELT is a transcriptional repressor expressed in the developing central nervous system. It binds preferentially to the canonical E box sequence 5'-CACGCG-3' and regulates neuronal differentiation and/or identity. Differentially expressed in chondrocytes proteins, DEC1 and DEC2, are widely expressed in both embryonic and adult tissues and have been implicated in apoptosis, cell proliferation, and circadian rhythms, as well as malignancy in various cancers. Drosophila melanogaster protein clockwork orange (Cwo) is also included in this subfamily. It is involved in the regulation of Drosophila circadian rhythms. It functions as both an activator and a repressor of clock gene expression. The HES subfamily proteins contain a basic helix-loop-helix (bHLH) domain with an invariant proline residue in its basic region, an orange domain in the central region and a conserved tetrapeptide motif, WRPW, at its C-terminal region. They form heterodimers or homodimers via their HLH domain and bind DNA to repress gene transcription that play an essential role in development of both compartment and boundary cells of the central nervous system.


Pssm-ID: 381528 [Multi-domain]  Cd Length: 52  Bit Score: 40.10  E-value: 1.64e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 31317299  69 MNGCYSRLKELVP---TLPQNRKVSKVEILQHVIDYIRDLQLEL 109
Cdd:cd19685   9 INDKLNQLKELLPpnlSKQSRSKLSKAEILEMAITELRRLQQEV 52
bHLHzip_Mlx_like cd11404
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-like protein X (Mlx) family; Mlx, ...
69-106 2.00e-05

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-like protein X (Mlx) family; Mlx, also termed Class D basic helix-loop-helix protein 13 (bHLHd13), or Max-like bHLHZip protein, or protein BigMax, or transcription factor-like protein 4, is a Max-like bHLHZip transcription regulator that interacts with the Max network of transcription factors. It forms a sequence-specific DNA-binding protein complex with some member of Mad family (Mad1 and Mad4) and Mondo family but not the Myc family and bind the E-box DNA to control transcription. The family also includes Saccharomyces cerevisiae INO4, which is a bHLH transcriptional activator of phospholipid synthetic genes (such as INO1, CHO1/PSS, CHO2/PEM1, OPI3/PEM2, etc.). It is required for de-repression of phospholipid biosynthetic gene expression in response to inositol deprivation in yeast.


Pssm-ID: 381410 [Multi-domain]  Cd Length: 70  Bit Score: 40.36  E-value: 2.00e-05
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 31317299  69 MNGCYSRLKELVPTLpQNRKVSKVEILQHVIDYIRDLQ 106
Cdd:cd11404  17 IKKGYDELCALVPGL-DPQKRTKADILQKAADWIQELK 53
bHLH_TS_scleraxis_like cd11465
basic helix-loop-helix (bHLH) domain found in scleraxis, transcription factor 15 (TCF-15) and ...
67-105 2.24e-05

basic helix-loop-helix (bHLH) domain found in scleraxis, transcription factor 15 (TCF-15) and similar proteins; The family includes scleraxis and transcription factor 15 (TCF-15). Scleraxis, also termed SCX, or Class A basic helix-loop-helix protein 41 (bHLHa41), or Class A basic helix-loop-helix protein 48 (bHLHa48), is a bHLH transcription factor that is expressed in sclerotome limb bud cranial and body wall mesenchyme, pericardium and heart valves, ligaments and tendons. It is required for tendon formation ligaments, connective tissue, the diaphragm, and testis development. Scleraxis plays a central role in promoting fibroblast proliferation and matrix synthesis during the embryonic development of tendons. TCF-15, also termed Class A basic helix-loop-helix protein 40 (bHLHa40), or paraxis, or protein bHLH-EC2, is a bHLH transcription factor expressed in caudal lateral and paraxial mesoderm dermomyotome and sclerotome fore limb buds during embryo development. It may function as an early transcriptional regulator involved in the patterning of the mesoderm and in lineage determination of cell types derived from the mesoderm.


Pssm-ID: 381471 [Multi-domain]  Cd Length: 55  Bit Score: 40.09  E-value: 2.24e-05
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 31317299  67 YDMNGCYSRLKELVPTLPQNRKVSKVEILQHVIDYIRDL 105
Cdd:cd11465  13 HSVNSAFTALRTLIPTEPADRKLSKIETLRLASSYISHL 51
bHLH_TS_ASCL3_like cd19724
basic helix-loop-helix (bHLH) domain found in achaete-scute-like proteins, ASCL3-5, and ...
70-106 3.91e-05

basic helix-loop-helix (bHLH) domain found in achaete-scute-like proteins, ASCL3-5, and similar proteins; This subfamily includes three ASCL family of transcription factors, ASCL-3, ASCL-4 and ASCL-5. ASCL-3, also termed Class A basic helix-loop-helix protein 42 (bHLHa42), or bHLH transcriptional regulator Sgn-1, or achaete-scute homolog 3 (ASH-3), is specifically localized in the duct cells of the salivary glands. It may act as transcriptional repressor that inhibits myogenesis. ASCL-4, also termed Class A basic helix-loop-helix protein 44 (bHLHa44), or achaete-scute homolog 4 (ASH-4), or Hash4, may be involved in skin development. ASCL-5, also termed Class A basic helix-loop-helix protein 47 (bHLHa47), or achaete-scute homolog 5 (ASH-5), is an uncharacterized bHLH transcription factor that is close related to ASCL-3 and ASCL-4.


Pssm-ID: 381567  Cd Length: 56  Bit Score: 39.21  E-value: 3.91e-05
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 31317299  70 NGCYSRLKELVPTLPQNRKVSKVEILQHVIDYIRDLQ 106
Cdd:cd19724  17 NEGYARLRRHLPLENKDKRLSKVETLRAAIRYIKHLQ 53
bHLH-O_HERP_like cd11389
basic helix-loop-helix-orange (bHLH-O) domain found in hairy and enhancer of split (HES) ...
69-106 5.04e-05

basic helix-loop-helix-orange (bHLH-O) domain found in hairy and enhancer of split (HES)-related repressor protein (HERP)-like family; The HERP-like family includes bHLH-O transcriptional regulators that are related to the Drosophila hairy and Enhancer-of-split proteins. They contain a basic helix-loop-helix (bHLH) domain with an invariant glycine residue in its basic region, an orange domain in the central region and YXXW sequence motif at its C-terminal region. HERP proteins (HEY1, HEY2 and HEYL) act as downstream effectors of Notch signaling. They are involved in cardiovascular development and have roles in somitogenesis, myogenesis and gliogenesis. Hairy and enhancer of split-related protein HELT is a transcriptional repressor expressed in the developing central nervous system. It binds preferentially to the canonical E box sequence 5'-CACGCG-3' and regulates neuronal differentiation and/or identity. Differentially expressed in chondrocytes proteins, DEC1 and DEC2, are widely expressed in both embryonic and adult tissues and have been implicated in apoptosis, cell proliferation, and circadian rhythms, as well as malignancy in various cancers. Drosophila melanogaster protein clockwork orange (Cwo) is also included in this family. It is involved in the regulation of Drosophila circadian rhythms. It functions as both an activator and a repressor of clock gene expression.


Pssm-ID: 381395 [Multi-domain]  Cd Length: 55  Bit Score: 38.84  E-value: 5.04e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 31317299  69 MNGCYSRLKELVPT---LPQNRKVSKVEILQHVIDYIRDLQ 106
Cdd:cd11389  12 INESLAELRRLVPEarkSKGSGKLEKAEILEMTLQHLKALQ 52
bHLH_TS_HEN1 cd19701
basic helix-loop-helix (bHLH) domain found in helix-loop-helix protein 1 (HEN-1) and similar ...
70-102 9.17e-05

basic helix-loop-helix (bHLH) domain found in helix-loop-helix protein 1 (HEN-1) and similar proteins; HEN-1, also termed nescient helix-loop-helix 1 (Nhlh1), or Class A basic helix-loop-helix protein 35 (bHLHa35), or nescient helix loop helix 1 (NSCL-1), is a neuron-specific bHLH transcription factor that may serve as DNA-binding protein and may be involved in the control of cell-type determination, possibly within the developing nervous system.


Pssm-ID: 381544 [Multi-domain]  Cd Length: 72  Bit Score: 38.87  E-value: 9.17e-05
                        10        20        30
                ....*....|....*....|....*....|...
gi 31317299  70 NGCYSRLKELVPTLPQNRKVSKVEILQHVIDYI 102
Cdd:cd19701  32 NVAFAELRKLLPTLPPDKKLSKIEILRLAICYI 64
bHLH_TS_ASCL1_Mash1 cd19742
basic helix-loop-helix (bHLH) domain found in achaete-scute-like protein 1 (ASCL-1) and ...
69-115 1.17e-04

basic helix-loop-helix (bHLH) domain found in achaete-scute-like protein 1 (ASCL-1) and similar proteins; ASCL-1, also termed Class A basic helix-loop-helix protein 46 (bHLHa46), or achaete-scute homolog 1 (ASH-1), or mammalian achaete scute homolog 1 (Mash1), is a neural-specific bHLH transcription factor that is expressed in subsets of neural progenitors in both the central and peripheral nervous system. It plays a key role in neuronal differentiation and specification in the nervous system.


Pssm-ID: 381585  Cd Length: 71  Bit Score: 38.58  E-value: 1.17e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
gi 31317299  69 MNGCYSRLKELVPTLPQNRKVSKVEILQHVIDYIRDLQLELNSESEV 115
Cdd:cd19742  20 VNMGFATLREHVPNGAANKKMSKVETLRSAVEYIRALQQLLDEHDAV 66
bHLH_TS_FERD3L_like cd19686
basic helix-loop-helix (bHLH) domain found in Fer3-like protein (FERD3L), pancreas ...
69-105 1.37e-04

basic helix-loop-helix (bHLH) domain found in Fer3-like protein (FERD3L), pancreas transcription factor 1 subunit alpha (PTF1A) and similar proteins; The family corresponds to a group of bHLH transcription factors, including FERD3L and PTF1A. FERD3L, also termed basic helix-loop-helix protein N-twist, or Class A basic helix-loop-helix protein 31 (bHLHa31), or nephew of atonal 3 (NATO3), or Neuronal twist (NTWIST), is expressed in the developing central nervous system (CNS). It regulates floor plate (FP) cells development. FP is a critical organizing center located at the ventral-most midline of the neural tube. FERD3L binds to the E-box and functions as inhibitor of transcription. PTF1A, also termed Class A basic helix-loop-helix protein 29 (bHLHa29), or pancreas-specific transcription factor 1a, or bHLH transcription factor p48, or p48 DNA-binding subunit of transcription factor PTF1 (PTF1-p48), is implicated in the cell fate determination in various organs. It binds to the E-box consensus sequence 5'-CANNTG-3' and plays a role in early and late pancreas development and differentiation.


Pssm-ID: 381529 [Multi-domain]  Cd Length: 56  Bit Score: 37.79  E-value: 1.37e-04
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 31317299  69 MNGCYSRLKELVPTLPQNRKVSKVEILQHVIDYIRDL 105
Cdd:cd19686  16 INDAFDGLRRHIPTFPYEKRLSKVDTLRLAIQYINFL 52
bHLH_TS_ASCL4 cd19746
basic helix-loop-helix (bHLH) domain found in achaete-scute-like protein 4 (ASCL-4) and ...
69-106 1.48e-04

basic helix-loop-helix (bHLH) domain found in achaete-scute-like protein 4 (ASCL-4) and similar proteins; ASCL-4, also termed Class A basic helix-loop-helix protein 44 (bHLHa44), or achaete-scute homolog 4 (ASH-4), or Hash4, is a bHLH transcriptional regulator that may be involved in skin development.


Pssm-ID: 381589  Cd Length: 64  Bit Score: 38.09  E-value: 1.48e-04
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 31317299  69 MNGCYSRLKELVPTLPQNRKVSKVEILQHVIDYIRDLQ 106
Cdd:cd19746  23 VNEGYARLREHLPQELADKRLSKVETLRAAIDYIKHLQ 60
bHLH_TS_ATOH1_like cd11430
basic helix-loop-helix (bHLH) domain found in protein atonal homologs ATOH1, ATOH7 and similar ...
66-109 1.77e-04

basic helix-loop-helix (bHLH) domain found in protein atonal homologs ATOH1, ATOH7 and similar proteins; The family includes ATOH1 and ATOH7. ATOH1, also termed Class A basic helix-loop-helix protein 14 (bHLHa14), or helix-loop-helix protein hATH-1 (hATH1), or Math1, or Cath1, is a proneural bHLH transcription factor that is essential for inner ear hair cell differentiation. It dimerizes with E47 and activates E-box (CANNTG) dependent transcription. ATOH1 is a mammalian homolog of the Drosophila melanogaster gene atonal and mouse atonal homolog 1 (Math1). ATOH7, also termed Class A basic helix-loop-helix protein 13 (bHLHa13), or helix-loop-helix protein hATH-5 (hATH5), or Math5, is a bHLH transcription factor involved in the differentiation of retinal ganglion cells. The family also includes protein Amos (also termed absent MD neurons and olfactory sensilla protein, or reduced olfactory organs protein, or rough eye protein). It is a bHLH transcription factor that promotes multiple dendritic neuron formation in the Drosophila peripheral nervous system.


Pssm-ID: 381436 [Multi-domain]  Cd Length: 56  Bit Score: 37.41  E-value: 1.77e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 31317299  66 LYDMNGCYSRLKELVPTLPQNRKVSKVEILQHVIDYIRDLQLEL 109
Cdd:cd11430  13 MNGLNRAFDQLRSVVPSIGNDKKLSKYETLQMAQIYIETLSELL 56
bHLHzip_Mlx cd19687
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-like protein X (Mlx) and similar ...
73-108 2.92e-04

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-like protein X (Mlx) and similar proteins; Mlx, also termed Class D basic helix-loop-helix protein 13 (bHLHd13), or Max-like bHLHZip protein, or protein BigMax, or transcription factor-like protein 4, is a Max-like bHLHZip transcription regulator that interacts with the Max network of transcription factors. It forms a sequence-specific DNA-binding protein complex with some member of Mad family (Mad1 and Mad4) and Mondo family but not the Myc family and bind the E-box DNA to control transcription.


Pssm-ID: 381530 [Multi-domain]  Cd Length: 76  Bit Score: 37.40  E-value: 2.92e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 31317299  73 YSRLKELVPTLPQN-----RKVSKVEILQHVIDYIRDLQLE 108
Cdd:cd19687  21 YDDLQDIVPTCQQQddigsQKLSKATILQRSIDYIQFLHQQ 61
bHLH_TS_ASCL2_Mash2 cd19743
basic helix-loop-helix (bHLH) domain found in achaete-scute-like protein 2 (ASCL-2) and ...
73-115 3.56e-04

basic helix-loop-helix (bHLH) domain found in achaete-scute-like protein 2 (ASCL-2) and similar proteins; ASCL-2, also termed achaete-scute homolog 2 (ASH-2), or Class A basic helix-loop-helix protein 45 (bHLHa45), or mammalian achaete scute homolog 2 (Mash2), is a bHLH transcription factor that is involved in Schwann cell differentiation and control of proliferation in adult peripheral nerves.


Pssm-ID: 381586  Cd Length: 64  Bit Score: 36.87  E-value: 3.56e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 31317299  73 YSRLKELVPTLPQNRKVSKVEILQHVIDYIRDLQLELNSESEV 115
Cdd:cd19743  22 FAALRQHVPQGGASKKMSKVETLRSAVEYIRALQRLLGEHDAE 64
bHLHzip_MLXIP cd19688
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MLX-interacting protein (MLXIP) and ...
67-108 3.66e-04

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MLX-interacting protein (MLXIP) and similar proteins; MLXIP, also termed Class E basic helix-loop-helix protein 36 (bHLHe36), or transcriptional activator MondoA, is a bHLHZip transcriptional activator that binds DNA as a heterodimer with Mlx. It binds to the canonical E box sequence 5'-CACGTG-3' and plays a role in transcriptional activation of glycolytic target genes. MLXIP is most highly expressed in skeletal muscle and functions as an indirect glucose sensor, by sensing glucose 6-phosphate and shuttling between the nucleus and the cytoplasm.


Pssm-ID: 381531  Cd Length: 72  Bit Score: 37.23  E-value: 3.66e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 31317299  67 YDMNGCYSRLKELVPTLPQNRKVSKVEILQHVIDYIRDLQLE 108
Cdd:cd19688  16 FNIKICFDTLNSLVSTLKNSKPISNAITLQKTVEYIAKLQQE 57
bHLH_TS_ATOH7 cd19714
basic helix-loop-helix (bHLH) domain found in protein atonal homolog 7 (ATOH7) and similar ...
69-105 4.14e-04

basic helix-loop-helix (bHLH) domain found in protein atonal homolog 7 (ATOH7) and similar proteins; ATOH7, also termed Class A basic helix-loop-helix protein 13 (bHLHa13), or helix-loop-helix protein hATH-5 (hATH5), or Math5, is a bHLH transcription factor involved in the differentiation of retinal ganglion cells.


Pssm-ID: 381557 [Multi-domain]  Cd Length: 69  Bit Score: 36.85  E-value: 4.14e-04
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 31317299  69 MNGCYSRLKELVPTLPQNRKVSKVEILQHVIDYIRDL 105
Cdd:cd19714  23 LNTAFDRLRKVVPQWGQDKKLSKYETLQMALSYIMAL 59
bHLH_TS_TAL2 cd19707
basic helix-loop-helix (bHLH) domain found in T-cell acute lymphocytic leukemia protein 2 ...
68-102 4.43e-04

basic helix-loop-helix (bHLH) domain found in T-cell acute lymphocytic leukemia protein 2 (TAL-2) and similar proteins; TAL-2, also termed Class A basic helix-loop-helix protein 19 (bHLHa19), is a bHLH transcription factor essential for the normal brain development. It has been implicated in T-cell acute lymphoblastic leukemia.


Pssm-ID: 381550 [Multi-domain]  Cd Length: 61  Bit Score: 36.51  E-value: 4.43e-04
                        10        20        30
                ....*....|....*....|....*....|....*
gi 31317299  68 DMNGCYSRLKELVPTLPQNRKVSKVEILQHVIDYI 102
Cdd:cd19707  16 NVNSAFAELRKLIPTHPPDKKLSKNEILRLAMKYI 50
bHLH_TS_NGN2_ATOH4 cd19717
basic helix-loop-helix (bHLH) domain found in neurogenin-2 (NGN-2) and similar proteins; NGN-2, ...
66-102 5.58e-04

basic helix-loop-helix (bHLH) domain found in neurogenin-2 (NGN-2) and similar proteins; NGN-2, also termed Class A basic helix-loop-helix protein 8 (bHLHa8), or protein atonal homolog 4 (ATOH4), is a neural-specific bHLH transcription factor required for sensory neurogenesis. It activates transcription by binding to the E box (5'-CANNTG-3').


Pssm-ID: 381560 [Multi-domain]  Cd Length: 69  Bit Score: 36.54  E-value: 5.58e-04
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 31317299  66 LYDMNGCYSRLKELVPTLPQNRKVSKVEILQHVIDYI 102
Cdd:cd19717  22 MHNLNAALDSLREVLPTFPEDAKLTKIETLRFAHNYI 58
bHLH_AtbHLH_like cd11393
basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana genes coding transcription ...
69-109 6.90e-04

basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana genes coding transcription factors and similar proteins; bHLH proteins are the second largest class of plant transcription factors that regulate transcription of genes that are involve in many essential physiological and developmental process. bHLH proteins are transcriptional regulators that are found in organisms from yeast to humans. The Arabidopsis bHLH proteins that have been characterized so far have roles in regulation of fruit dehiscence, cell development (carpel, anther and epidermal), phytochrome signaling, flavonoid biosynthesis, hormone signaling and stress responses.


Pssm-ID: 381399 [Multi-domain]  Cd Length: 53  Bit Score: 36.01  E-value: 6.90e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 31317299  69 MNGCYSRLKELVPTLPqnrKVSKVEILQHVIDYIRDLQLEL 109
Cdd:cd11393  12 INERIRALRSLVPNGG---KTDKASILDEAIEYIKFLQEQV 49
bHLHzip_Mnt cd11402
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-binding protein Mnt and similar ...
72-106 8.37e-04

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-binding protein Mnt and similar proteins; Mnt, also termed Class D basic helix-loop-helix protein 3 (bHLHd3), or Myc antagonist MNT, or protein ROX, is a bHLHZip transcriptional repressor that binds DNA as a heterodimer with MAX. It binds to the canonical E box sequence 5'-CACGTG-3' and, with higher affinity, to 5'-CACGCG-3'. Mnt has an important role as an antagonist and regulator of Myc activities and it is a potential tumor suppressor. Mnt is ubiquitously expressed. Mnt-deficient mice shown to exhibit early postnatal lethality.


Pssm-ID: 381408 [Multi-domain]  Cd Length: 77  Bit Score: 36.14  E-value: 8.37e-04
                        10        20        30
                ....*....|....*....|....*....|....*
gi 31317299  72 CYSRLKELVPTLpQNRKVSKVEILQHVIDYIRDLQ 106
Cdd:cd11402  20 CFETLKRQIPNL-DDKKTSNLNILRSALRYIQILK 53
bHLH_TS_HEN2 cd19702
basic helix-loop-helix (bHLH) domain found in helix-loop-helix protein 2 (HEN-2) and similar ...
70-105 9.26e-04

basic helix-loop-helix (bHLH) domain found in helix-loop-helix protein 2 (HEN-2) and similar proteins; HEN-2, also termed nescient helix-loop-helix 2 (Nhlh2), or Class A basic helix-loop-helix protein 34 (bHLHa34), or nescient helix loop helix 2 (NSCL-2), is a neuron-specific bHLH transcription factor that may serve as DNA-binding protein and may be involved in the control of cell-type determination, possibly within the developing nervous system.


Pssm-ID: 381545 [Multi-domain]  Cd Length: 73  Bit Score: 36.22  E-value: 9.26e-04
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 31317299  70 NGCYSRLKELVPTLPQNRKVSKVEILQHVIDYIRDL 105
Cdd:cd19702  32 NLAFAELRKLLPTLPPDKKLSKIEILRLAICYISYL 67
bHLHzip_N-Myc_like cd11456
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in N-Myc and similar proteins; N-Myc, ...
56-108 9.70e-04

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in N-Myc and similar proteins; N-Myc, also termed Class E basic helix-loop-helix protein 37 (bHLHe37), is a bHLHZip proto-oncogene protein that positively regulates the transcription of MYCNOS in neuroblastoma cells. It is also essential during embryonic development. N-Myc has a critical role in regulating the switch between proliferation and differentiation of progenitor cells. It binds DNA as a heterodimer with MAX. The family also includes S-Myc, encoded by rat or mouse intronless myc gene, which has apoptosis-inducing activity.


Pssm-ID: 381462 [Multi-domain]  Cd Length: 87  Bit Score: 36.42  E-value: 9.70e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 31317299  56 LLDEQQVNvllyDMNGCYSRLKELVPTLPQNRKVSKVEILQHVIDYIRDLQLE 108
Cdd:cd11456  11 ILERQRRN----DLRSSFLTLRDHVPELVKNEKAAKVVILKKATEYVHSLQAE 59
bHLHzip_USF_MITF cd11387
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in USF/MITF family; The USF (upstream ...
70-106 9.84e-04

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in USF/MITF family; The USF (upstream stimulatory factor)/MITF (microphthalmia-associated transcription factor) family includes two bHLHzip transcription factor subfamilies. USFs are ubiquitously expressed and key regulators of a wide number of gene regulation networks, including the stress and immune responses, cell cycle and proliferation, lipid and glucid metabolism. USFs recruit chromatin remodeling enzymes and interact with co-activators and the members of the transcription pre-initiation complex. USFs interact with high affinity to E-box regulatory elements. The MITF (also known as microphthalmia-TFE, or MiT) subfamily comprises four genes in mammals (MITF, TFE3, TFEB, and TFEC); each gene has different functions. MITF is involved in neural crest melanocytes development as well as the pigmented retinal epithelium. TFEB is required for vascularization of the mouse placenta. TFE3 is involved in B cell function. TFEC regulates gene expression in macrophages. The MITF subfamily proteins can form homodimers or heterodimers with each other but not with other bHLH or bHLHzip proteins.


Pssm-ID: 381393 [Multi-domain]  Cd Length: 58  Bit Score: 35.69  E-value: 9.84e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 31317299  70 NGCYSRLKELVPTLPQNR---KVSKVEILQHVIDYIRDLQ 106
Cdd:cd11387  14 NEKIQELGSLVPPSRLETkdlKPNKGSILSKAVEYIRELQ 53
bHLHzip_SREBP_like cd11395
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in sterol regulatory element-binding ...
69-106 1.02e-03

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in sterol regulatory element-binding protein (SREBP) family and similar proteins; The SREBP family includes SREBP1 and SREBP2, which are bHLHzip transcriptional activator of genes encoding proteins essential for cholesterol biosynthesis/uptake and fatty acid biosynthesis. SREBP1 and SREBP2 are principally found in the liver and in adipocytes and made up of an N-terminal transcription factor portion (composed of an activation domain, a bHLHzip domain, and a nuclear localization signal), a hydrophobic region containing two membrane spanning regions, and a C-terminal regulatory segment. They recognize a symmetric sterol regulatory element (TCACNCCAC) instead of E-box. The family also includes Saccharomyces cerevisiae transcription factor HMS1 (also termed high-copy MEP suppressor protein 1) and serine-rich protein TYE7. HMS1 is a putative bHLHzip transcription factor involved in exit from mitosis and pseudohyphal differentiation. TYE7, also termed basic-helix-loop-helix protein SGC1, is a putative bHLHzip transcription activator required for Ty1-mediated glycolytic gene expression. TYE7 N-terminal is extremely rich in serine residues. It binds DNA on E-box motifs, 5'-CANNTG-3'. TYE7 is not essential for growth.


Pssm-ID: 381401 [Multi-domain]  Cd Length: 87  Bit Score: 36.16  E-value: 1.02e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 31317299  69 MNGCYSRLKELVPTLPQN---------------RKVSKVEILQHVIDYIRDLQ 106
Cdd:cd11395  18 LNTKIERLRDAIPSLRSPegksddgglgglaptTKLSKATILTKAIEYIRHLE 70
bHLH_TS_scleraxis cd18951
basic helix-loop-helix (bHLH) domain found in scleraxis and similar proteins; Scleraxis, also ...
69-105 1.16e-03

basic helix-loop-helix (bHLH) domain found in scleraxis and similar proteins; Scleraxis, also termed SCX, or Class A basic helix-loop-helix protein 41 (bHLHa41), or Class A basic helix-loop-helix protein 48 (bHLHa48), is a bHLH transcription factor that is expressed in sclerotome limb bud cranial and body wall mesenchyme, pericardium and heart valves, ligaments and tendons. It is required for tendon formation ligaments, connective tissue, the diaphragm, and testis development. Scleraxis plays a central role in promoting fibroblast proliferation and matrix synthesis during the embryonic development of tendons.


Pssm-ID: 381521 [Multi-domain]  Cd Length: 68  Bit Score: 35.90  E-value: 1.16e-03
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 31317299  69 MNGCYSRLKELVPTLPQNRKVSKVEILQHVIDYIRDL 105
Cdd:cd18951  19 VNTAFTALRTLIPTEPADRKLSKIETLRLASSYISHL 55
bHLHzip_MLXIP_like cd11405
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MLX-interacting protein (MLXIP), ...
67-108 1.57e-03

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MLX-interacting protein (MLXIP), MLX-interacting protein-like (MLXIPL) and similar proteins; The family includes MLXIP and MLXIPL. MLXIP, also termed Class E basic helix-loop-helix protein 36 (bHLHe36), or transcriptional activator MondoA, is a bHLHZip transcriptional activator that binds DNA as a heterodimer with Mlx. It binds to the canonical E box sequence 5'-CACGTG-3' and plays a role in transcriptional activation of glycolytic target genes. MLXIP is most highly expressed in skeletal muscle and functions as an indirect glucose sensor, by sensing glucose 6-phosphate and shuttling between the nucleus and the cytoplasm. MLXIPL, also termed carbohydrate-responsive element-binding protein (ChREBP), or Class D basic helix-loop-helix protein 14 (bHLHd14), or MLX interactor, or WS basic-helix-loop-helix leucine zipper protein (WS-bHLH), or Williams-Beuren syndrome chromosomal region 14 protein (WBSCR14), is a bHLHZip transcriptional factor integral to the regulation of glycolysis and lipogenesis in the liver. It forms heterodimers with the bHLHZip protein Mlx to bind the DNA sequence 5'-CACGTG-3'.


Pssm-ID: 381411 [Multi-domain]  Cd Length: 74  Bit Score: 35.33  E-value: 1.57e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 31317299  67 YDMNGCYSRLKELVPTL--PQNRKVSKVEILQHVIDYIRDLQLE 108
Cdd:cd11405  16 FNIKSGFDTLQSLIPSLgqNPNQKVSKAAMLQKAAEYIKSLKRE 59
bHLH-O_HERP cd11407
basic helix-loop-helix-orange (bHLH-O) domain found in hairy and enhancer of split (HES) ...
69-106 1.72e-03

basic helix-loop-helix-orange (bHLH-O) domain found in hairy and enhancer of split (HES)-related repressor protein (HERP) family; HERP (also called Hey/Hesr/HRT/CHF/gridlock) proteins corresponds to a family of bHLH-O transcriptional repressors that are related to the Drosophila hairy and Enhancer-of-split proteins and act as downstream effectors of Notch signaling. They contain a basic helix-loop-helix (bHLH) domain with an invariant glycine residue in its basic region, an orange domain in the central region and YXXW sequence motif at its C-terminal region. HERP proteins are involved in cardiovascular development and have roles in somitogenesis, myogenesis and gliogenesis.


Pssm-ID: 381413 [Multi-domain]  Cd Length: 59  Bit Score: 35.09  E-value: 1.72e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 31317299  69 MNGCYSRLKELVPTLPQNR---KVSKVEILQHVIDYIRDLQ 106
Cdd:cd11407  16 INNSLAELRRLVPTAFEKQgsaKLEKAEILQMTVDHLKMLH 56
bHLHzip_Max cd11406
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in protein Max and similar proteins; Max, ...
71-106 1.80e-03

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in protein Max and similar proteins; Max, also termed Class D basic helix-loop-helix protein 4 (bHLHd4), or Myc-associated factor X, is a bHLHZip transcription regulator that forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a transcriptional repressor. Max homodimer bind DNA but is transcriptionally inactive. Targeted deletion of max results in early embryonic lethality in mice.


Pssm-ID: 381412  Cd Length: 69  Bit Score: 35.02  E-value: 1.80e-03
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 31317299  71 GCYSRLKELVPTLpQNRKVSKVEILQHVIDYIRDLQ 106
Cdd:cd11406  18 DSFHSLRDSVPSL-QGEKASRAQILKKATEYIQYMR 52
bHLH_TS_PTF1A cd11417
basic helix-loop-helix (bHLH) domain found in pancreas transcription factor 1 subunit alpha ...
69-106 3.26e-03

basic helix-loop-helix (bHLH) domain found in pancreas transcription factor 1 subunit alpha (PTF1A) and similar proteins; PTF1A, also termed Class A basic helix-loop-helix protein 29 (bHLHa29), or pancreas-specific transcription factor 1a, or bHLH transcription factor p48, or p48 DNA-binding subunit of transcription factor PTF1 (PTF1-p48), is a bHLH transcription factor implicated in the cell fate determination in various organs. It binds to the E-box consensus sequence 5'-CANNTG-3' and plays a role in early and late pancreas development and differentiation.


Pssm-ID: 381423 [Multi-domain]  Cd Length: 56  Bit Score: 34.05  E-value: 3.26e-03
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 31317299  69 MNGCYSRLKELVPTLPQNRKVSKVEILQHVIDYIRDLQ 106
Cdd:cd11417  16 INDAFEGLRSHIPTLPYEKRLSKVDTLRLAIGYINFLS 53
bHLHzip_spESC1_like cd19690
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Schizosaccharomyces pombe ESC1 (spESC1) ...
68-111 4.45e-03

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Schizosaccharomyces pombe ESC1 (spESC1) and similar proteins; spESC1 is a bHLHzip protein with homology to human MyoD and Myf-5 myogenic differentiation inducers. It is involved in the sexual differentiation process.


Pssm-ID: 381533  Cd Length: 65  Bit Score: 33.97  E-value: 4.45e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 31317299  68 DMNGCYSRLKELvptLPQNR--KVSKVEILQHVIDYI-------RDLQLELNS 111
Cdd:cd19690  14 EMKELFEDLRDA---LPQERgtKASKWEILTKAISYIqqlkrhiRELRSEVND 63
bHLH_TS_ASCL3 cd19745
basic helix-loop-helix (bHLH) domain found in achaete-scute-like protein 3 (ASCL-3) and ...
69-106 4.95e-03

basic helix-loop-helix (bHLH) domain found in achaete-scute-like protein 3 (ASCL-3) and similar proteins; ASCL-3, also termed Class A basic helix-loop-helix protein 42 (bHLHa42), or bHLH transcriptional regulator Sgn-1, or achaete-scute homolog 3 (ASH-3), is a bHLH transcription factor specifically localized in the duct cells of the salivary glands. It may act as transcriptional repressor that inhibits myogenesis.


Pssm-ID: 381588  Cd Length: 59  Bit Score: 33.68  E-value: 4.95e-03
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 31317299  69 MNGCYSRLKELVPTLPQNRKVSKVEILQHVIDYIRDLQ 106
Cdd:cd19745  19 VNEGYAKLRRHLPQEYSEKRLSKVETLRAAIKYIKHLQ 56
bHLH_AtPIF_like cd11445
basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana phytochrome interacting ...
75-110 5.03e-03

basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana phytochrome interacting factors (PIFs) and similar proteins; The family includes several bHLH transcription factors from Arabidopsis thaliana, such as PIFs, ALC, PIL1, SPATULA, and UNE10. PIFs (PIF1, PIF3, PIF4, PIF5, PIF6 and PIF7) have been shown to control light-regulated gene expression. They directly bind to the photoactivated phytochromes and are degraded in response to light signals. ALC, also termed AtbHLH73, or protein ALCATRAZ, or EN 98, is required for the dehiscence of fruit, especially for the separation of the valve cells from the replum. It promotes the differentiation of a strip of labile non-lignified cells sandwiched between layers of lignified cells. PIL1, also termed AtbHLH124, or protein phytochrome interacting factor 3-like 1, or EN 110, is involved in responses to transient and long-term shade. It is required for the light-mediated inhibition of hypocotyl elongation and necessary for rapid light-induced expression of the photomorphogenesis- and circadian-related gene APRR9. PIL1 seems to play a role in multiple PHYB responses, such as flowering transition and petiole elongation. SPATULA, also termed AtbHLH24, or EN 99, plays a role in floral organogenesis. It promotes the growth of carpel margins and of pollen tract tissues derived from them. UNE10, also termed AtbHLH16, or protein UNFERTILIZED EMBRYO SAC 10, or EN 99, is required during the fertilization of ovules by pollen.


Pssm-ID: 381451  Cd Length: 64  Bit Score: 33.88  E-value: 5.03e-03
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 31317299  75 RLKELVPTLPQNRKVSKVEILQHVIDYIRDLQLELN 110
Cdd:cd11445  20 KMKALQELIPNCNKTDKASMLDEAIEYLKSLQLQVQ 55
bHLH_TS_ASCL5 cd19747
basic helix-loop-helix (bHLH) domain found in achaete-scute-like protein 5 (ASCL-5) and ...
69-106 5.34e-03

basic helix-loop-helix (bHLH) domain found in achaete-scute-like protein 5 (ASCL-5) and similar proteins; ASCL-5, also termed Class A basic helix-loop-helix protein 47 (bHLHa47), or achaete-scute homolog 5 (ASH-5), is an uncharacterized bHLH transcription factor that belongs to AS-C (achaete, scute, lethal of scute, and asense) family.


Pssm-ID: 381590  Cd Length: 61  Bit Score: 33.82  E-value: 5.34e-03
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 31317299  69 MNGCYSRLKELVPTLPQNRKVSKVEILQHVIDYIRDLQ 106
Cdd:cd19747  21 VNEGYARLRDHLPGAMAEKRLSKVETLRAAIRYIKYLQ 58
bHLH-O_Cwo_like cd11440
basic helix-loop-helix-orange (bHLH-O) domain found in Drosophila melanogaster protein ...
69-109 5.76e-03

basic helix-loop-helix-orange (bHLH-O) domain found in Drosophila melanogaster protein clockwork orange (Cwo) and similar proteins; Cwo is a bHLH-O transcriptional regulator involved in the regulation of Drosophila circadian rhythms. It functions as both an activator and a repressor of clock gene expression.


Pssm-ID: 381446 [Multi-domain]  Cd Length: 60  Bit Score: 33.61  E-value: 5.76e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 31317299  69 MNGCYSRLKELVPT--LPQNR-KVSKVEILQHVIDYIRDLQLEL 109
Cdd:cd11440  17 MNNCLADLSRLIPPtyLKKGRgRIEKTEIIEMAIKHIKHLQQHA 60
bHLHzip_TFAP4 cd11419
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor AP-4 (TFAP4) and ...
70-109 6.29e-03

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor AP-4 (TFAP4) and similar proteins; TFAP4, also termed activating enhancer-binding protein 4, or Class C basic helix-loop-helix protein 41 (bHLHc41), is a bHLHzip transcription factor that activates both viral and cellular genes involved in the regulation of cellular proliferation, stemness, and epithelial-mesenchymal transition by binding to the symmetrical DNA sequence 5'-CAGCTG-3'.


Pssm-ID: 381425  Cd Length: 61  Bit Score: 33.44  E-value: 6.29e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 31317299  70 NGCYSRLKELVPTLpQNRKVSKVEILQHVIDYIRDLQLEL 109
Cdd:cd11419  20 NAGFQSLRTLLPHC-DGEKLSKAAILQQTAEYIFSLEQEK 58
bHLH_TS_TCF15_paraxis cd11470
basic helix-loop-helix (bHLH) domain found in transcription factor 15 (TCF-15) and similar ...
69-105 6.46e-03

basic helix-loop-helix (bHLH) domain found in transcription factor 15 (TCF-15) and similar proteins; TCF-15, also termed Class A basic helix-loop-helix protein 40 (bHLHa40), or paraxis, or protein bHLH-EC2, is a bHLH transcription factor expressed in caudal lateral and paraxial mesoderm dermomyotome and sclerotome fore limb buds during embryo development. It may function as an early transcriptional regulator involved in the patterning of the mesoderm and in lineage determination of cell types derived from the mesoderm.


Pssm-ID: 381476 [Multi-domain]  Cd Length: 66  Bit Score: 33.52  E-value: 6.46e-03
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 31317299  69 MNGCYSRLKELVPTLPQNRKVSKVEILQHVIDYIRDL 105
Cdd:cd11470  23 VNTAFTALRTLIPTEPVDRKLSKIETLRLASSYIAHL 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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