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Conserved domains on  [gi|4504697|ref|NP_002182|]
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inhibin alpha chain preproprotein [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TGF_beta_SF super family cl40434
transforming growth factor beta (TGF-beta) like domain found in TGF-beta superfamily; TGF-beta ...
 261-366 4.21e-52

transforming growth factor beta (TGF-beta) like domain found in TGF-beta superfamily; TGF-beta superfamily consists of a large group of cell regulatory proteins, such as TFG-betas, Nodal, Activins/Inhibins, glial cell-line-derived neurotrophic factor (GDNF) family of ligands, bone morphogenetic proteins (BMPs), and growth and differentiation factors (GDFs). They play important roles in developmental and physiological processes in a variety of species, including invertebrates as well as vertebrates, through specific receptor complexes that are composed of type I and type II serine/threonine receptor kinases. The receptor kinases subsequently activate Smad proteins, which then propagate the signals into the nucleus to regulate target gene expression. Proteins from the TGF-beta superfamily are only active as homo- or heterodimer.


The actual alignment was detected with superfamily member cd13754:

Pssm-ID: 477357  Cd Length: 89  Bit Score: 168.01  E-value: 4.21e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504697  261 NCHRVALNISFQELGWERWIVYPPSFIFHYCHGGCGLHIPPNLSlpvpgapptpaqpysllPGAQPCCAALPGTMRPLHV 340
Cdd:cd13754   1 NCHRASLNISFEELGWGNWIVHPSSFTFHYCHGTCSSSHGLTPA-----------------LGIQLCCAAVPGTMRSLRV 63

                        90       100
                ....*....|....*....|....*.
gi 4504697  341 RTTSDGGYSFKYETVPNLLTQHCACI 366
Cdd:cd13754  64 RTTSDGGYSFKYETVPNILTQDCACI 89
 
Name Accession Description Interval E-value
TGF_beta_INHA cd13754
transforming growth factor beta (TGF-beta) like domain found in inhibin alpha chain (INHA) and ...
 261-366 4.21e-52

transforming growth factor beta (TGF-beta) like domain found in inhibin alpha chain (INHA) and similar proteins; INHA is a component of inhibins (inhibin A or inhibin B) that inhibit the secretion of follitropin by the pituitary gland.


Pssm-ID: 381632  Cd Length: 89  Bit Score: 168.01  E-value: 4.21e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504697  261 NCHRVALNISFQELGWERWIVYPPSFIFHYCHGGCGLHIPPNLSlpvpgapptpaqpysllPGAQPCCAALPGTMRPLHV 340
Cdd:cd13754   1 NCHRASLNISFEELGWGNWIVHPSSFTFHYCHGTCSSSHGLTPA-----------------LGIQLCCAAVPGTMRSLRV 63

                        90       100
                ....*....|....*....|....*.
gi 4504697  341 RTTSDGGYSFKYETVPNLLTQHCACI 366
Cdd:cd13754  64 RTTSDGGYSFKYETVPNILTQDCACI 89
TGFB smart00204
Transforming growth factor-beta (TGF-beta) family; Family members are active as ...
 262-366 1.17e-27

Transforming growth factor-beta (TGF-beta) family; Family members are active as disulphide-linked homo- or heterodimers. TGFB is a multifunctional peptide that controls proliferation, differentiation, and other functions in many cell types.


Pssm-ID: 214556  Cd Length: 102  Bit Score: 104.67  E-value: 1.17e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504697     262 CHRVALNISFQELGWERWIVYPPSFIFHYCHGGCGLHIPPNLSLPVPGAPPTPAQPYSLLPGAQPCCAalPGTMRPLHVR 341
Cdd:smart00204   1 CRRRQLYVDFKDLGWDDWIIAPKGYNAYYCEGECPFPLSTSLNATNHAIVQTLVHLLGPNPVPKPCCV--PTKLSPLSML 78

                           90       100
                   ....*....|....*....|....*
gi 4504697     342 TTSDGGYSFKYEtVPNLLTQHCACI 366
Cdd:smart00204  79 YYDDDGNVVLRN-YPNMVVEECGCR 102
TGF_beta pfam00019
Transforming growth factor beta like domain;
261-365 1.01e-19

Transforming growth factor beta like domain;


Pssm-ID: 459632  Cd Length: 102  Bit Score: 83.14  E-value: 1.01e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504697    261 NCHRVALNISFQELGWERWIVYPPSFIFHYCHGGCGLHIPPNLSlpvpgapPTP-----AQPYSLLPGA--QPCCAalPG 333
Cdd:pfam00019   1 ECRRHSLYVDFEDLGWDDWIIAPKGYNAYYCSGSCPSHLNPQLS-------ATNhailqSLLHSLKPANvpKPCCV--PT 71

                          90       100       110
                  ....*....|....*....|....*....|..
gi 4504697    334 TMRPLHVRTTSDGGySFKYETVPNLLTQHCAC 365
Cdd:pfam00019  72 KLSPLSVLYYDDEG-NVVLKTYPDMVVESCGC 102
PHA02913 PHA02913
TGF-beta-like protein; Provisional
 260-365 2.20e-05

TGF-beta-like protein; Provisional


Pssm-ID: 177497  Cd Length: 172  Bit Score: 44.63  E-value: 2.20e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504697   260 ANCHRVALNISFQ-ELGWeRWIVYPPSFIFHYCHGGCGLHIPPNLSLPVpGAPPTPAQPYSLLPgaqPCCAalPGTMRPL 338
Cdd:PHA02913  75 AICCIRDFNIDFKaDMGM-KWILKPEGTHANLCIGICSISNHKKINLMY-GTAFKHHMPDNTIP---FCCA--PIKMKNF 147

                         90       100
                 ....*....|....*....|....*..
gi 4504697   339 HVRTTSdgGYSFKYETVPNLLTQHCAC 365
Cdd:PHA02913 148 IIAYKE--GRKIKTDNIKNFKILECAC 172
 
Name Accession Description Interval E-value
TGF_beta_INHA cd13754
transforming growth factor beta (TGF-beta) like domain found in inhibin alpha chain (INHA) and ...
 261-366 4.21e-52

transforming growth factor beta (TGF-beta) like domain found in inhibin alpha chain (INHA) and similar proteins; INHA is a component of inhibins (inhibin A or inhibin B) that inhibit the secretion of follitropin by the pituitary gland.


Pssm-ID: 381632  Cd Length: 89  Bit Score: 168.01  E-value: 4.21e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504697  261 NCHRVALNISFQELGWERWIVYPPSFIFHYCHGGCGLHIPPNLSlpvpgapptpaqpysllPGAQPCCAALPGTMRPLHV 340
Cdd:cd13754   1 NCHRASLNISFEELGWGNWIVHPSSFTFHYCHGTCSSSHGLTPA-----------------LGIQLCCAAVPGTMRSLRV 63

                        90       100
                ....*....|....*....|....*.
gi 4504697  341 RTTSDGGYSFKYETVPNLLTQHCACI 366
Cdd:cd13754  64 RTTSDGGYSFKYETVPNILTQDCACI 89
TGF_beta_INHA_B_like cd19377
transforming growth factor beta (TGF-beta) like domain found in inhibin alpha chain (INHA), ...
 262-365 9.70e-48

transforming growth factor beta (TGF-beta) like domain found in inhibin alpha chain (INHA), beta chain (INHB) and similar proteins; INHA is a component of inhibins (inhibin A or inhibin B) that inhibit the secretion of follitropin by the pituitary gland. INHB includes inhibin beta A chain (INHBA), B chain (INHBB), C chain (INHBC), and E chain (INHBE). INHBA, also termed activin beta-A chain, or erythroid differentiation protein (EDF), is a component of inhibin A, activin A, or activin AB. Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. INHBB, also termed activin beta-B chain, is a component of inhibin B, activin A, or activin AB. Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. INHBC, also termed activin beta-C chain, might play important roles in carcinogenesis. It may function as a negative regulator of liver growth. INHBE, also termed activin beta-E chain, is a possible insulin resistance-associated hepatokine with hepatic gene expression that positively correlated with insulin resistance and body mass index in humans. It also acts as a possible new marker for drug-induced endoplasmic reticulum stress.


Pssm-ID: 381647  Cd Length: 101  Bit Score: 156.87  E-value: 9.70e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504697  262 CHRVALNISFQELGWERWIVYPPSFIFHYCHGGCGLHIPPNLSLPVPGAPPTPAQPYSLLPGAQPCCAALPGtmRPLHVR 341
Cdd:cd19377   1 CCRVALFVSFEELGWNRWIIAPPGFNFHFCHGGCALHIVPDLSLPVPSAPPTPARPYSVLPGAQPCCAPTKV--TPLSVL 78

                        90       100
                ....*....|....*....|....
gi 4504697  342 TTSDgGYSFKYETVPNLLTQHCAC 365
Cdd:cd19377  79 YTSD-GGTIKYETIPDLIVQECGC 101
TGFB smart00204
Transforming growth factor-beta (TGF-beta) family; Family members are active as ...
 262-366 1.17e-27

Transforming growth factor-beta (TGF-beta) family; Family members are active as disulphide-linked homo- or heterodimers. TGFB is a multifunctional peptide that controls proliferation, differentiation, and other functions in many cell types.


Pssm-ID: 214556  Cd Length: 102  Bit Score: 104.67  E-value: 1.17e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504697     262 CHRVALNISFQELGWERWIVYPPSFIFHYCHGGCGLHIPPNLSLPVPGAPPTPAQPYSLLPGAQPCCAalPGTMRPLHVR 341
Cdd:smart00204   1 CRRRQLYVDFKDLGWDDWIIAPKGYNAYYCEGECPFPLSTSLNATNHAIVQTLVHLLGPNPVPKPCCV--PTKLSPLSML 78

                           90       100
                   ....*....|....*....|....*
gi 4504697     342 TTSDGGYSFKYEtVPNLLTQHCACI 366
Cdd:smart00204  79 YYDDDGNVVLRN-YPNMVVEECGCR 102
TGF_beta pfam00019
Transforming growth factor beta like domain;
261-365 1.01e-19

Transforming growth factor beta like domain;


Pssm-ID: 459632  Cd Length: 102  Bit Score: 83.14  E-value: 1.01e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504697    261 NCHRVALNISFQELGWERWIVYPPSFIFHYCHGGCGLHIPPNLSlpvpgapPTP-----AQPYSLLPGA--QPCCAalPG 333
Cdd:pfam00019   1 ECRRHSLYVDFEDLGWDDWIIAPKGYNAYYCSGSCPSHLNPQLS-------ATNhailqSLLHSLKPANvpKPCCV--PT 71

                          90       100       110
                  ....*....|....*....|....*....|..
gi 4504697    334 TMRPLHVRTTSDGGySFKYETVPNLLTQHCAC 365
Cdd:pfam00019  72 KLSPLSVLYYDDEG-NVVLKTYPDMVVESCGC 102
TGF_beta_BMPs_GDFs cd13756
transforming growth factor beta (TGF-beta) like domain found in the BMP/GDF family; The BMP ...
 262-365 2.04e-13

transforming growth factor beta (TGF-beta) like domain found in the BMP/GDF family; The BMP/GDF family consists of bone morphogenetic proteins (BMPs), growth and differentiation factors (GDFs) and similar proteins. BMPs are a group of growth factors also known as cytokines and as metabologens. They induce the formation of bone and cartilage and functions as pivotal morphogenetic signals, orchestrating tissue architecture throughout the body. GDFs have functions predominantly in development.


Pssm-ID: 381634  Cd Length: 102  Bit Score: 65.80  E-value: 2.04e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504697  262 CHRVALNISFQELGWERWIVYPPSFIFHYCHGGCGLHIPPNLSlpvpgapPTP--------AQPYSLLPGAQPCCAalPG 333
Cdd:cd13756   1 CRRRPLYVDFSDLGWDDWIIAPKGYNANYCAGSCPFPLSSHAN-------ATNhailqallHSLNPKKSVPKPCCV--PT 71

                        90       100       110
                ....*....|....*....|....*....|..
gi 4504697  334 TMRPLHVrTTSDGGYSFKYETVPNLLTQHCAC 365
Cdd:cd13756  72 KYSPLSV-LYYDEDGNVVLKTYPDMVVEECGC 102
TGF_beta_GDF8_like cd13751
transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factors, ...
 262-365 1.13e-12

transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factors, GDF8 and GDF11, and similar proteins; The family includes GDF8 and GDF11. GDF8, also termed myostatin, acts specifically as a negative regulator of skeletal muscle growth. GDF11, also termed bone morphogenetic protein 11 (BMP-11), is a secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development.


Pssm-ID: 381629  Cd Length: 96  Bit Score: 63.44  E-value: 1.13e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504697  262 CHRVALNISFQELGWErWIVYPPSFIFHYCHGGCglhipPNLSLpvpgapptPAQPYSLL-------PGAQPCCAalPGT 334
Cdd:cd13751   3 CCRYPLTVDFEEFGWD-WIIAPKTYDANYCSGEC-----PFVYL--------QSYPHTHLvqqanprGSAGPCCT--PTK 66

                        90       100       110
                ....*....|....*....|....*....|.
gi 4504697  335 MRPLHVrTTSDGGYSFKYETVPNLLTQHCAC 365
Cdd:cd13751  67 MSPLSM-LYFDEDGNIIYGTLPDMVVERCGC 96
TGF_beta_INHB cd13752
transforming growth factor beta (TGF-beta) like domain found in inhibin beta A chain (INHBA), ...
 262-365 1.97e-12

transforming growth factor beta (TGF-beta) like domain found in inhibin beta A chain (INHBA), B chain (INHBB), C chain (INHBC), E chain (INHBE) and similar proteins; The family includes inhibin beta A chain (INHBA), B chain (INHBB), C chain (INHBC), and E chain (INHBE). INHBA, also termed activin beta-A chain, or erythroid differentiation protein (EDF), is a component of inhibin A, activin A, or activin AB. Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. INHBB, also termed activin beta-B chain, is a component of inhibin B, activin A, or activin AB. Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. INHBC, also termed activin beta-C chain, might play important roles in carcinogenesis. It may function as a negative regulator of liver growth. INHBE, also termed activin beta-E chain, is a possible insulin resistance-associated hepatokine with hepatic gene expression that positively correlated with insulin resistance and body mass index in humans. It also acts as a possible new marker for drug-induced endoplasmic reticulum stress.


Pssm-ID: 381630  Cd Length: 100  Bit Score: 62.67  E-value: 1.97e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504697  262 CHRVALNISFQELGWERWIVYPPSFIFHYCHGGCGLHIPPNLSlPVPGAPPTPAQPYSLLPGAQPCCAalPGTMRPLHVR 341
Cdd:cd13752   1 CCRESFYVSFTDIGWDDWIIAPSGYYANYCKGSCSGSSSPFRS-HHTTILQKYLSKNKAKSELTPCCT--PTKMSPLSLL 77

                        90       100
                ....*....|....*....|....
gi 4504697  342 TTSDGGYSFKyETVPNLLTQHCAC 365
Cdd:cd13752  78 YYDSDGNIVK-KDLPNMIVESCGC 100
TGF_beta_BMP3 cd19393
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 3 ...
 261-365 3.93e-12

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 3 (BMP-3) and similar proteins; BMP-3, also termed BMP-3A, or osteogenin, negatively regulates bone density. It antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossification.


Pssm-ID: 381663  Cd Length: 110  Bit Score: 62.36  E-value: 3.93e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504697  261 NCHRVALNISFQELGWERWIVYPPSFIFHYCHGGCGLHIPPNLSLPVPGAPPTPAQPYSLLPG-AQPCCaaLPGTMRPLH 339
Cdd:cd19393   7 NCARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPSNHATIQSIVRAVGVVPGiPEPCC--VPEKMSSLS 84

                        90       100
                ....*....|....*....|....*.
gi 4504697  340 VrTTSDGGYSFKYETVPNLLTQHCAC 365
Cdd:cd19393  85 I-LFFDENKNVVLKVYPNMTVESCAC 109
TGF_beta_GDP9_9B_like cd13762
transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor ...
 262-365 2.46e-11

transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor 9 (GDF-9), growth/differentiation factor 9B (GDF-9B) and similar proteins; The family includes GDF-9B (also known as BMP15) and GDF9. GDF-9B acts as oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth. GDF-9 is required for ovarian folliculogenesis. It promotes primordial follicle development and stimulates granulosa cell proliferation.


Pssm-ID: 381640  Cd Length: 104  Bit Score: 59.77  E-value: 2.46e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504697  262 CHRVALNISFQELGWERWIVYPPSFIFHYCHGGCglhippnlslpvpgaPPTPAQPYS-------------LLPGAQPCC 328
Cdd:cd13762   3 CRRHRLRVRFRDLKWNGWIIAPTRYTANYCKGTC---------------PRVLGQDLNptnhaivqnilhhLLDKSVPRP 67

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 4504697  329 AALPGTMRPLHVRTTSDGGySFKYETVPNLLTQHCAC 365
Cdd:cd13762  68 SCVPTELHPLSVLYYEEDG-SIIYKEYPDMVASSCGC 103
TGF_beta_GDF1_3_like cd13764
transforming growth factor beta (TGF-beta) like domain found in embryonic growth ...
 262-340 1.75e-09

transforming growth factor beta (TGF-beta) like domain found in embryonic growth/differentiation factor 1 (GDF1), factor 3 (GDF3) and similar proteins; The family includes GDF-1 and GDF-3. GDF1 may mediate cell differentiation events during embryonic development. GDF3 is a growth factor involved in early embryonic development and adipose-tissue homeostasis. The family also contains protein DVR-1, also termed vegetal hemisphere VG1 protein (VG-1), which serves to facilitate the differentiation of either mesoderm or endoderm either as a cofactor in an instructive signal or by providing permissive environment.


Pssm-ID: 381642  Cd Length: 102  Bit Score: 54.39  E-value: 1.75e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504697  262 CHRVALNISFQELGWERWIVYPPSFIFHYCHGGCGLhiPPNLSLPVPGAPPTPAQPYSLLPGA--QPCCAalPGTMRPLH 339
Cdd:cd13764   1 CKKRRLYISFRDVGWQNWIIAPQGYMANYCHGECPF--PLTESLNGTNHAILQTLVHSVDPEGtpQPCCV--PTRLSPIS 76


                .
gi 4504697  340 V 340
Cdd:cd13764  77 M 77
TGF_beta_GDF10 cd19394
transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor ...
 262-365 3.09e-09

transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor 10 (GDF10) and similar proteins; GDF10, also termed bone morphogenetic protein 3B (BMP-3B), or bone-inducing protein (BIP), is a growth factor involved in osteogenesis and adipogenesis.


Pssm-ID: 381664  Cd Length: 112  Bit Score: 54.15  E-value: 3.09e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504697  262 CHRVALNISFQELGWERWIVYPPSFIFHYCHGGCGLHIPPNLSLPVPGAPPTPAQPYSLLPGA-QPCCaaLPGTMRPLHV 340
Cdd:cd19394  10 CSRRYLKVDFADIGWSEWIISPKSFDAYYCAGACEFPMPKVVRPSNHATIQSIVKAVGIIPGVpEPCC--VPDKMNSLSV 87

                        90       100
                ....*....|....*....|....*
gi 4504697  341 rTTSDGGYSFKYETVPNLLTQHCAC 365
Cdd:cd19394  88 -LFLDENRNVVLKVYPNMSVETCAC 111
TGF_beta_GDF15 cd19376
transforming growth factor beta (TGF-beta) like domain found in mammalian growth ...
 261-365 3.29e-09

transforming growth factor beta (TGF-beta) like domain found in mammalian growth/differentiation factor 15 (GDF-15) and similar proteins; GDF-15, also termed macrophage inhibitory cytokine 1 (MIC-1), or NSAID-activated gene 1 protein (NAG-1), or NSAID-regulated gene 1 protein (NRG-1), or placental TGF-beta, or placental bone morphogenetic protein, or prostate differentiation factor, regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses.


Pssm-ID: 381646  Cd Length: 101  Bit Score: 53.85  E-value: 3.29e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504697  261 NCHRVALNISFQELGWERWIVYPPSFIFHYCHGGCglhiPPNLSlpvpgapptPAQPYSLL--------PGA--QPCCAa 330
Cdd:cd19376   2 RCCRFSLRVSFKEIGWADWVLAPESYNAYYCDGSC----PHNYK---------PANMHAQIksrlhrlnPGAvpAPCCV- 67

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 4504697  331 lPGTMRPLHV-RTTSDGGYSFKyeTVPNLLTQHCAC 365
Cdd:cd19376  68 -PSSYEPLTLlHYDSDGKLTLT--EFDDMIVKDCHC 100
TGF_beta_SF cd08698
transforming growth factor beta (TGF-beta) like domain found in TGF-beta superfamily; TGF-beta ...
 262-365 3.80e-09

transforming growth factor beta (TGF-beta) like domain found in TGF-beta superfamily; TGF-beta superfamily consists of a large group of cell regulatory proteins, such as TFG-betas, Nodal, Activins/Inhibins, glial cell-line-derived neurotrophic factor (GDNF) family of ligands, bone morphogenetic proteins (BMPs), and growth and differentiation factors (GDFs). They play important roles in developmental and physiological processes in a variety of species, including invertebrates as well as vertebrates, through specific receptor complexes that are composed of type I and type II serine/threonine receptor kinases. The receptor kinases subsequently activate Smad proteins, which then propagate the signals into the nucleus to regulate target gene expression. Proteins from the TGF-beta superfamily are only active as homo- or heterodimer.


Pssm-ID: 381627  Cd Length: 100  Bit Score: 53.64  E-value: 3.80e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504697  262 CHRVALNISFQELGWERWIVYPPSFIFHYCHGGCGLHIpPNLSLPVPGAPPTPAQPYSLLPGAQPCCAalPGTMRPLHVR 341
Cdd:cd08698   1 CCKQPLYVNFKDLGGLNWIIAPSGFTANYCRGSCNSES-SATTNHTKLLQWSRTRRHTPREELKPCCV--PTSYEPLSIL 77

                        90       100
                ....*....|....*....|....*
gi 4504697  342 TTSDGGysFKYET-VPNLLTQHCAC 365
Cdd:cd08698  78 YYDNNG--TVVETlLPNLIVTECGC 100
TGF_beta_BMP3_like cd13763
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 3 ...
 262-366 4.51e-09

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 3 (BMP-3), growth/differentiation factor 10 (GDF10) and similar proteins; The family includes BMP-3 (also known as BMP-3A or osteogenin) and GDF10 (also known as BMP-3B). BMP-3 negatively regulates bone density. It antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossification. GDF10 is a growth factor involved in osteogenesis and adipogenesis.


Pssm-ID: 381641  Cd Length: 103  Bit Score: 53.52  E-value: 4.51e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504697  262 CHRVALNISFQELGWERWIVYPPSFIFHYCHGGCGLHIPPNLSL-----------PVPGAPPTPAqpysllpgaqPCCAa 330
Cdd:cd13763   1 CSRRPLTVDFADIGWSDWIISPKSFDAYYCAGSCPFPLTKELRPsnhatiqsivhAVGIQPGVPA----------PCCV- 69

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 4504697  331 lPGTMRPLHVRTTSDGGySFKYETVPNLLTQHCACI 366
Cdd:cd13763  70 -PDKMSSLTLLYFDENR-NVVLKNYPNMTVESCACR 103
TGF_beta_BMP5_like cd13761
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic proteins ...
 262-295 5.08e-09

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic proteins BMP-5, BMP-6, BMP-7, BMP-8A/B and similar proteins; The family includes BMP-5, BMP-6, BMP-7 and BMP-8A/B, which may induce cartilage and bone formation.


Pssm-ID: 381639  Cd Length: 103  Bit Score: 53.35  E-value: 5.08e-09
                        10        20        30
                ....*....|....*....|....*....|....
gi 4504697  262 CHRVALNISFQELGWERWIVYPPSFIFHYCHGGC 295
Cdd:cd13761   2 CRRHNLYVDFRDLGWQDWIIAPDGYNAYYCSGEC 35
TGF_beta_DAF7 cd19378
transforming growth factor beta (TGF-beta) like domain found in Caenorhabditis elegans Dauer ...
 267-365 6.14e-09

transforming growth factor beta (TGF-beta) like domain found in Caenorhabditis elegans Dauer larva development regulatory growth factor DAF-7 and similar proteins; DAF-7, also termed abnormal dauer formation protein 7, may act as a negative regulator of dauer larva development by transducing chemosensory information from ASI neurons. It is involved in sensitivity to CO2 levels.


Pssm-ID: 381648  Cd Length: 100  Bit Score: 53.11  E-value: 6.14e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504697  267 LNISFQELGWeRWIVYPPSFIFHYCHGGCGLHIPPNLSLPVPGAPPTpaQPYSLLPGAQPCCAalPGTMRPLHVRTTSDG 346
Cdd:cd19378   8 LTIDFEEIGW-NFIIAPKKYNANMCRGDCKSNHHHRPNSASILLNPI--TRSESKQEHGSCCH--PTEYDPITVVYFNED 82

                        90
                ....*....|....*....
gi 4504697  347 GySFKYETVPNLLTQHCAC 365
Cdd:cd19378  83 G-QLKIKTINGMIAKKCSC 100
TGF_beta_LEFTY1_2 cd13758
transforming growth factor beta (TGF-beta) like domain found in left-right determination ...
 262-365 4.86e-08

transforming growth factor beta (TGF-beta) like domain found in left-right determination factor 1 (lefty-1), factor 2 (lefty-2) and similar proteins; Lefty-1, also termed left-right determination factor B, or protein lefty-B, is required for left-right axis determination as a regulator of Lefty-2 and NODAL. Lefty-2, also termed endometrial bleeding-associated factor, or left-right determination factor A, or protein lefty-A, or transforming growth factor beta-4 (TGF-beta-4), is required for left-right (L-R) asymmetry determination of organ systems in mammals. It may play a role in endometrial bleeding.


Pssm-ID: 381636  Cd Length: 90  Bit Score: 50.06  E-value: 4.86e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504697  262 CHRVALNISFQELGW-ERWIVYPPSFIFHYCHGGCglhippnlslpvpgapPTPAQPYSLLPGAQPCCAALPGTMRPLHV 340
Cdd:cd13758   2 CCRQEYYIDFRELTWtDYWIIEPPGYQAYECVGGC----------------PQPPPPLAWPSLGHRQCGVSESASLPMMY 65

                        90       100
                ....*....|....*....|....*
gi 4504697  341 RTTSDGGYSFKYETVPNLLTQHCAC 365
Cdd:cd13758  66 LVKKGDYTEVEVAEFPNMIVEKCGC 90
TGF_beta_BMP4_BMP2B cd19391
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 4 ...
 261-295 1.63e-07

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 4 (BMP-4) and similar proteins; BMP-4, also termed BMP-2B, induces cartilage and bone formation. It also acts in mesoderm induction, tooth development, limb formation and fracture repair.


Pssm-ID: 381661  Cd Length: 107  Bit Score: 49.28  E-value: 1.63e-07
                        10        20        30
                ....*....|....*....|....*....|....*
gi 4504697  261 NCHRVALNISFQELGWERWIVYPPSFIFHYCHGGC 295
Cdd:cd19391   6 NCRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDC 40
TGF_beta_TGFbeta1_2_3 cd13753
transforming growth factor beta (TGF-beta) like domain found in transforming growth factor ...
 267-365 1.69e-07

transforming growth factor beta (TGF-beta) like domain found in transforming growth factor beta-1 (TGF-beta-1), beta-2 (TGF-beta-2), beta-3 (TGF-beta-3) and similar proteins; The family includes TGF-beta-1, TGF-beta-2 and TGF-beta-3, which are polypeptide members of the transforming growth factor beta superfamily of cytokines. TGF-beta-1 is a secreted protein that performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation, and apoptosis. TGF-beta-2 is a secreted protein that performs many cellular functions and has a vital role during embryonic development. It can suppress the effects of interleukin-2 dependent T-cell growth. TGF-beta-3 is involved in embryogenesis and cell differentiation. It regulates molecules involved in cellular adhesion and extracellular matrix (ECM) formation during the process of palate development.


Pssm-ID: 381631  Cd Length: 97  Bit Score: 48.84  E-value: 1.69e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504697  267 LNISFQ-ELGWErWIVYPPSFIFHYCHGGCglhippnlslPVPGAPPTPAQPY-----SLLPGA--QPCCAalPGTMRPL 338
Cdd:cd13753   6 LYINFRrDLGWK-WIHEPKGFNANYCAGAC----------PYLWSADTQHSTVlqlynRLNPVAsaAPCCS--PRELEPL 72

                        90       100
                ....*....|....*....|....*..
gi 4504697  339 HVRTTSDGGYsfKYETVPNLLTQHCAC 365
Cdd:cd13753  73 TILYYDGRNP--KIETLSNMIVTSCKC 97
TGF_beta_GDF8 cd19388
transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor ...
 254-365 2.91e-07

transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor 8 (GDF8) and similar proteins; GDF8, also termed myostatin, acts specifically as a negative regulator of skeletal muscle growth.


Pssm-ID: 381658  Cd Length: 108  Bit Score: 48.49  E-value: 2.91e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504697  254 EEPAAHANCHRVALNISFQELGWErWIVYPPSFIFHYCHGGCG---LHIPPNLSLpVPGAPPTPAqpysllpgAQPCCAa 330
Cdd:cd19388   6 DEHSTESRCCRYPLTVDFEAFGWD-WIIAPKRYKANYCSGECEfvfLQKYPHTHL-VHQANPRGS--------AGPCCT- 74

                        90       100       110
                ....*....|....*....|....*....|....*
gi 4504697  331 lPGTMRPLHVrTTSDGGYSFKYETVPNLLTQHCAC 365
Cdd:cd19388  75 -PTKMSPINM-LYFNGKEQIIYGKIPAMVVDRCGC 107
TGF_beta_BMP2 cd19390
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 2 ...
 260-365 3.44e-07

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 2 (BMP-2) and similar proteins; BMP-2, also termed BMP-2A, induces cartilage and bone formation. It stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway.


Pssm-ID: 381660  Cd Length: 103  Bit Score: 48.06  E-value: 3.44e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504697  260 ANCHRVALNISFQELGWERWIVYPPSFIFHYCHGGCGLHIPPNLSLPVPGAPPTPAQPY-SLLPGAqpCCaaLPGTMRPL 338
Cdd:cd19390   1 SSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAIVQTLVNSVnSKIPKA--CC--VPTELSAI 76

                        90       100
                ....*....|....*....|....*..
gi 4504697  339 HVRTTSDGGYSFKyETVPNLLTQHCAC 365
Cdd:cd19390  77 SMLYLDENEKVVL-KNYQDMVVEGCGC 102
TGF_beta_INHBA cd19404
transforming growth factor beta (TGF-beta) like domain found in inhibin beta A chain (INHBA) ...
 262-365 4.91e-07

transforming growth factor beta (TGF-beta) like domain found in inhibin beta A chain (INHBA) and similar proteins; INHBA, also termed activin beta-A chain, or erythroid differentiation protein (EDF), is a component of inhibin A, activin A, or activin AB. Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland.


Pssm-ID: 381674  Cd Length: 108  Bit Score: 47.61  E-value: 4.91e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504697  262 CHRVALNISFQELGWERWIVYPPSFIFHYCHGGCGLHIP----PNLSLPVPGAPPTPAQPYSLLPGAQPCCaaLPGTMRP 337
Cdd:cd19404   3 CCKKQFYVSFKDIGWSDWIIAPSGYHANYCEGECPSHIAgtsgSSLSFHSTVINHYRMRGYSPFANLKSCC--VPTKLRA 80

                        90       100
                ....*....|....*....|....*...
gi 4504697  338 LHVRTTSDGGYSFKyETVPNLLTQHCAC 365
Cdd:cd19404  81 MSMLYYDDGQNIIK-KDIQNMIVEECGC 107
TGF_beta_GSDF cd19379
transforming growth factor beta (TGF-beta) like domain found in Danio rerio gonadal somatic ...
 262-328 9.21e-07

transforming growth factor beta (TGF-beta) like domain found in Danio rerio gonadal somatic cell derived factor (GSDF) and similar proteins; GSDF is a new member of transforming growth factor beta (TGF-beta) superfamily. It is a teleost- and gonad-specific growth factor that controls sex determination in some fish and plays an important role in mediating germ cell/soma signaling.


Pssm-ID: 381649  Cd Length: 94  Bit Score: 46.59  E-value: 9.21e-07
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4504697  262 CHRVALNISFQELGWERWIVYPPSFIFHYCHG-GCGLHIPPNLSLPVPGAPPTPAQPysllpgaqPCC 328
Cdd:cd19379   3 CCQETSEIFFKDLGWENWVIYPESFTYVQCVGcNAGRNSSESQCRQRLQGRAGARQE--------RCC 62
TGF_beta_BMP10 cd19401
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 10 ...
 262-365 1.00e-06

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 10 (BMP-10) and similar proteins; BMP-10 is required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. It inhibits endothelial cell migration and growth. It may reduce cell migration and cell matrix adhesion in breast cancer cell lines.


Pssm-ID: 381671  Cd Length: 105  Bit Score: 46.77  E-value: 1.00e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504697  262 CHRVALNISFQELGWERWIVYPPSFIFHYCHGGCGLHIPPNLSLPVPGAPPTPAQPYSLLPGAQPCCaaLPGTMRPLHVR 341
Cdd:cd19401   3 CKRSPLYVDFKEIGWDSWIIAPTGYEAYECRGVCYYPLTEHVTPTKHAIVQTLVHLKNPQKASKACC--VPTKLDPISIL 80

                        90       100
                ....*....|....*....|....*..
gi 4504697  342 TTSDGG---YSFKYEtvpNLLTQHCAC 365
Cdd:cd19401  81 YLDDAGvvtYKFKYE---GMVVAECGC 104
TGF_beta_BMP2_like cd13760
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 2 ...
 262-304 1.02e-06

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 2 (BMP-2), 4 (BMP-4) and similar proteins; The family includes BMP2 and BMP4 (also known as BMP2B), both of which induce cartilage and bone formation. BMP-2 stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP-4 acts in mesoderm induction, tooth development, limb formation and fracture repair.


Pssm-ID: 381638  Cd Length: 102  Bit Score: 46.71  E-value: 1.02e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 4504697  262 CHRVALNISFQELGWERWIVYPPSFIFHYCHGGCGLHIPPNLS 304
Cdd:cd13760   1 CRRHSLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLN 43
TGF_beta_NODAL cd13759
transforming growth factor beta (TGF-beta) like domain found in Nodal (NODAL)-related proteins; ...
 261-338 1.18e-06

transforming growth factor beta (TGF-beta) like domain found in Nodal (NODAL)-related proteins; NODAL is essential for mesoderm formation and axial patterning during embryonic development.


Pssm-ID: 381637  Cd Length: 103  Bit Score: 46.53  E-value: 1.18e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504697  261 NCHRVALNISFQELGWERWIVYPPSFIFHYCHGGCGLHI-----PPN-------LSLPVPGAPPtpaqpysllpgaQPCC 328
Cdd:cd13759   2 LCRRVDFYVDFDRIGWGSWIVYPKKYNAYRCEGECPSPVdedfkPTNhaymqslLKLYQPDRVP------------LPCC 69

                        90
                ....*....|
gi 4504697  329 AalPGTMRPL 338
Cdd:cd13759  70 V--PTKLSPL 77
TGF_beta_INHBC_E cd19406
transforming growth factor beta (TGF-beta) like domain found in inhibin beta C chain (INHBC), ...
 262-365 1.23e-06

transforming growth factor beta (TGF-beta) like domain found in inhibin beta C chain (INHBC), inhibin beta E chain (INHBE) and similar proteins; The family includes INHBC and INHBE. INHBC, also termed activin beta-C chain, might play important roles in carcinogenesis. It may function as a negative regulator of liver growth. INHBE, also termed activin beta-E chain, is a possible insulin resistance-associated hepatokine with hepatic gene expression that positively correlated with insulin resistance and body mass index in humans. It also acts as a possible new marker for drug-induced endoplasmic reticulum stress.


Pssm-ID: 381676  Cd Length: 104  Bit Score: 46.69  E-value: 1.23e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504697  262 CHRVALNISFQELGWERWIVYPPSFIFHYCHGGCGLHIP--PNLSLPVPGAPPTPAQPYSLLPGAQPCCaaLPGTMRPLH 339
Cdd:cd19406   1 CCRRDFYVDFKDIGWNDWIIKPEGYQMNYCMGQCPLHIAgsPGIAASFHTAVLNLVKANNIATAVHSCC--VPTARRPLS 78

                        90       100
                ....*....|....*....|....*.
gi 4504697  340 VRTTSDGGYSFKYEtVPNLLTQHCAC 365
Cdd:cd19406  79 LLYFDRNSNIVKTD-IPDMIVEACGC 103
TGF_beta_INHBB cd19405
transforming growth factor beta (TGF-beta) like domain found in inhibin beta B chain (INHBB) ...
 262-365 1.62e-06

transforming growth factor beta (TGF-beta) like domain found in inhibin beta B chain (INHBB) and similar proteins; INHBB, also termed activin beta-B chain, is a component of inhibin B, activin A, or activin AB. Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland.


Pssm-ID: 381675  Cd Length: 107  Bit Score: 46.46  E-value: 1.62e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504697  262 CHRVALNISFQELGWERWIVYPPSFIFHYCHGGCGLHIppnlslpvPGAPPTPAQPYSLLPGAQPCCAALPGTMR----P 337
Cdd:cd19405   3 CCRQQFYIDFRLIGWNDWIIAPVGYYGNYCEGSCPAYM--------AGVPGSASSFHTAVVNQYRMRGMNPGTVNscciP 74

                        90       100       110
                ....*....|....*....|....*....|..
gi 4504697  338 LHVRTTS----DGGYSFKYETVPNLLTQHCAC 365
Cdd:cd19405  75 TKLSTMSmlyfDDEYNIVKRDVPNMIVEECGC 106
TGF_beta_univin cd19387
transforming growth factor beta (TGF-beta) like domain found in Strongylocentrotus purpuratus ...
 262-295 1.87e-06

transforming growth factor beta (TGF-beta) like domain found in Strongylocentrotus purpuratus univin and similar proteins; Univin may have a critical role in early developmental decisions in the sea urchin embryo.


Pssm-ID: 381657  Cd Length: 104  Bit Score: 45.95  E-value: 1.87e-06
                        10        20        30
                ....*....|....*....|....*....|....
gi 4504697  262 CHRVALNISFQELGWERWIVYPPSFIFHYCHGGC 295
Cdd:cd19387   3 CQRHSLYVDFKDVGWSDWIIAPRGYQAYRCAGEC 36
TGF_beta_GDF5 cd19399
transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor ...
 262-365 2.28e-06

transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor 5 (GDF5) and similar proteins; GDF5, also termed bone morphogenetic protein 14 (BMP-14), or cartilage-derived morphogenetic protein 1 (CDMP-1), or lipopolysaccharide-associated protein 4 (LAP-4), or LPS-associated protein 4, or radotermin, is a growth factor involved in bone and cartilage formation.


Pssm-ID: 381669  Cd Length: 103  Bit Score: 45.77  E-value: 2.28e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504697  262 CHRVALNISFQELGWERWIVYPPSFIFHYCHGGCGLHIPPNLSlpvpgaPPTPAQPYSLL----PGAQPCCAALPGTMRP 337
Cdd:cd19399   2 CSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLE------PTNHAVIQTLMnsmdPESTPPTCCVPTRLSP 75

                        90       100
                ....*....|....*....|....*...
gi 4504697  338 LHVRTTsDGGYSFKYETVPNLLTQHCAC 365
Cdd:cd19399  76 ISILFI-DSANNVVYKQYEDMVVESCGC 102
TGF_beta_BMP9 cd19400
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 9 ...
 262-365 2.50e-06

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 9 (BMP-9) and similar proteins; BMP-9, also termed growth/differentiation factor 2 (GDF-2), is a potent circulating inhibitor of angiogenesis. It signals through the type I activin receptor ACVRL1 but not other activin receptor-like kinases (ALKs).


Pssm-ID: 381670  Cd Length: 105  Bit Score: 45.64  E-value: 2.50e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504697  262 CHRVALNISFQELGWERWIVYPPSFIFHYCHGGCGLHIPPNLSlpvpgaPPTPAQPYSLLPGAQP------CCaaLPGTM 335
Cdd:cd19400   3 CRKTSLRVNFKDIGWDSWIIAPKEYDAYECKGGCYFPLTDDVT------PTKHAIIQTLVHLKNPkkagkaCC--VPTKL 74

                        90       100       110
                ....*....|....*....|....*....|...
gi 4504697  336 RPLHVRTTSDGG---YSFKYEtvpNLLTQHCAC 365
Cdd:cd19400  75 DPISVLYKDDMGvptLKYHYE---GMKVAECGC 104
TGF_beta_BMP8 cd19398
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 8A ...
 262-365 2.96e-06

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 8A (BMP-8A), 8B (BMP-8B) and similar proteins; BMP-8A plays a role in the maintenance of spermatogenesis and the integrity of the epididymis. BMP-8B, also termed BMP-8, or osteogenic protein 2 (OP-2), may act as secreted factor in cancer progression. It also plays an essential role in bone metabolism and can regulate thermogenesis and energy balance. Like BMP-8A, BMP-8B plays a role in spermatogenesis and placental development. Mutation in either of the genes encoding BMP-8A or BMP-8B causes postnatal depletion of spermatogonia in mice.


Pssm-ID: 381668  Cd Length: 105  Bit Score: 45.30  E-value: 2.96e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504697  262 CHRVALNISFQELGWERWIVYPPSFIFHYCHGGCGLhiPPNLSLPVPGAPPTPAQPYSLLPGA--QPCCAalPGTMRPLH 339
Cdd:cd19398   4 CKRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSF--PLDSCMNATNHAILQSLVHLMKPEAvpKACCA--PTKLSATS 79

                        90       100
                ....*....|....*....|....*.
gi 4504697  340 VrTTSDGGYSFKYETVPNLLTQHCAC 365
Cdd:cd19398  80 V-LYYDSNNNVILKKHRNMVVKSCGC 104
TGF_beta_BMP7 cd19397
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 7 ...
 262-365 3.61e-06

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 7 (BMP-7) and similar proteins; BMP-7, also termed osteogenic protein 1 (OP-1), or eptotermin alfa, induces cartilage and bone formation. It may act as the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis and play a role in calcium regulation and bone homeostasis.


Pssm-ID: 381667  Cd Length: 107  Bit Score: 45.42  E-value: 3.61e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504697  262 CHRVALNISFQELGWERWIVYPPSFIFHYCHGGCGLhiPPNLSLPVPGAPPTPAQPYSLLPGA--QPCCAalPGTMRPLH 339
Cdd:cd19397   6 CKKHELYVSFRDLGWQDWIIAPEGYAAYYCEGECAF--PLNSYMNATNHAIVQTLVHFINPETvpKPCCA--PTQLNAIS 81

                        90       100
                ....*....|....*....|....*...
gi 4504697  340 VRTTSDGGYSF--KYEtvpNLLTQHCAC 365
Cdd:cd19397  82 VLYFDDSSNVIlkKYR---NMVVRACGC 106
TGF_beta_GDF5_6_7 cd13766
transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor ...
 262-365 5.41e-06

transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor 5 (GDF5), factor 6 (GDF6), factor 7 (GDF7) and similar proteins; The family includes GDF5, GDF6 and GDF7. GDF5, also termed bone morphogenetic protein 14 (BMP-14), or cartilage-derived morphogenetic protein 1 (CDMP-1), or lipopolysaccharide-associated protein 4 (LAP-4), or LPS-associated protein 4, or radotermin, is a growth factor involved in bone and cartilage formation. GDF6, also termed bone morphogenetic protein 13 (BMP-13), or growth/differentiation factor 16, is a growth factor that controls proliferation and cellular differentiation in the retina and bone formation. GDF7, also termed bone morphogenetic protein 12 (BMP-12), may play an active role in the motor area of the primate neocortex.


Pssm-ID: 381644  Cd Length: 102  Bit Score: 44.73  E-value: 5.41e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504697  262 CHRVALNISFQELGWERWIVYPPSFIFHYCHGGCGLHIPPNLSlpvpgaPPTPAQPYSLL----PGAQP--CCaaLPGTM 335
Cdd:cd13766   1 CSRKPLHVNFKDLGWDDWIIAPLDYEAYHCEGVCDFPLRSHLE------PTNHAIIQTLMnsmdPESTPpsCC--VPTKL 72

                        90       100       110
                ....*....|....*....|....*....|
gi 4504697  336 RPLHVRTTsDGGYSFKYETVPNLLTQHCAC 365
Cdd:cd13766  73 SPISILYI-DSANNVVYKQYEDMVVESCGC 101
TGF_beta_DPP cd19392
transforming growth factor beta (TGF-beta) like domain found in Drosophila melanogaster ...
 262-304 5.62e-06

transforming growth factor beta (TGF-beta) like domain found in Drosophila melanogaster protein decapentaplegic (Dpp) and similar proteins; decapentaplegic (Dpp) and similar proteins Dpp, also termed as protein DPP-C, is required later in embryogenesis for dorsal closure and patterning of the hindgut. It also functions postembryonically as a long-range morphogen during imaginal disk development and is responsible for the progression of the morphogenetic furrow during eye development.


Pssm-ID: 381662  Cd Length: 109  Bit Score: 44.83  E-value: 5.62e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 4504697  262 CHRVALNISFQELGWERWIVYPPSFIFHYCHGGCGLHIPPNLS 304
Cdd:cd19392   8 CRRHPLYVDFSDVGWDDWIVAPLGYDAYYCNGECPFPLADYLN 50
TGF_beta_BMP6 cd19396
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 6 ...
 262-365 7.39e-06

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 6 (BMP-6) and similar proteins; BMP-6, also termed VG-1-related protein, or VG-1-R, or VGR-1, induces cartilage and bone formation.


Pssm-ID: 381666  Cd Length: 103  Bit Score: 44.26  E-value: 7.39e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504697  262 CHRVALNISFQELGWERWIVYPPSFIFHYCHGGCGLHIPPNLSLPVPGAPPTPAQPYSLLPGAQPCCAalPGTMRPLHVR 341
Cdd:cd19396   2 CRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVHLMNPEYVPKPCCA--PTKLNAISVL 79

                        90       100
                ....*....|....*....|....*.
gi 4504697  342 TTSDGGYSF--KYEtvpNLLTQHCAC 365
Cdd:cd19396  80 YFDDNSNVIlkKYR---NMVVRACGC 102
TGF_beta_BMP5 cd19395
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 5 ...
 262-365 1.62e-05

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 5 (BMP-5) and similar proteins; BMP-5 induces cartilage and bone formation.


Pssm-ID: 381665  Cd Length: 113  Bit Score: 43.53  E-value: 1.62e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504697  262 CHRVALNISFQELGWERWIVYPPSFIFHYCHGGCGLhiPPNLSLPVPGAPPTPAQPYSLLPG--AQPCCAalPGTMRPLH 339
Cdd:cd19395  12 CKKHELYVSFRDLGWQDWIIAPEGYAAFYCDGECSF--PLNAHMNATNHAIVQTLVHLMFPDnvPKPCCA--PTKLNAIS 87

                        90       100
                ....*....|....*....|....*.
gi 4504697  340 VRTTSDGGySFKYETVPNLLTQHCAC 365
Cdd:cd19395  88 VLYFDDSS-NVILKKYRNMVVRSCGC 112
TGF_beta_GDF9B cd19402
transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor ...
 261-321 1.94e-05

transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor 9B (GDF-9B) and similar proteins; GDF-9B, also termed bone morphogenetic protein 15 (BMP15), acts as oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth.


Pssm-ID: 381672  Cd Length: 104  Bit Score: 43.26  E-value: 1.94e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4504697  261 NCHRVALNISFQELGWERWIVYPPSFIFHYCHGGC------GLHIPP------------NLSLPVPGAPPTPAQPYSLL 321
Cdd:cd19402   2 QCSLHSFWVSFHQLGWDHWIIAPHRYNPGYCKGDCprilhyGYNSPNhaivqnfinqlvDANVPRPSCVPYKYGPISVL 80
PHA02913 PHA02913
TGF-beta-like protein; Provisional
 260-365 2.20e-05

TGF-beta-like protein; Provisional


Pssm-ID: 177497  Cd Length: 172  Bit Score: 44.63  E-value: 2.20e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504697   260 ANCHRVALNISFQ-ELGWeRWIVYPPSFIFHYCHGGCGLHIPPNLSLPVpGAPPTPAQPYSLLPgaqPCCAalPGTMRPL 338
Cdd:PHA02913  75 AICCIRDFNIDFKaDMGM-KWILKPEGTHANLCIGICSISNHKKINLMY-GTAFKHHMPDNTIP---FCCA--PIKMKNF 147

                         90       100
                 ....*....|....*....|....*..
gi 4504697   339 HVRTTSdgGYSFKYETVPNLLTQHCAC 365
Cdd:PHA02913 148 IIAYKE--GRKIKTDNIKNFKILECAC 172
TGF_beta_maverick cd13755
transforming growth factor beta (TGF-beta) like domain found in Drosophila melanogaster ...
 262-365 4.13e-05

transforming growth factor beta (TGF-beta) like domain found in Drosophila melanogaster maverick and similar proteins; Maverick, also termed MAV, is a novel member of the TGF-beta superfamily in Drosophila. It's a bone morphogenetic protein (BMP)/TGF-beta related ligand.


Pssm-ID: 381633  Cd Length: 102  Bit Score: 41.91  E-value: 4.13e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504697  262 CHRVALNISFQEL-GWErWIVYPPSFIFHYCHGGCglhiPPNLSlpvpgapptPAQPYSLLPG---------AQPCCAal 331
Cdd:cd13755   4 CCRHSLKVDFKKLpGFE-WIIQPKEFDAGYCKGRC----PPRYN---------YANNHALIQSllrrmkkkvPRPCCA-- 67

                        90       100       110
                ....*....|....*....|....*....|....*
gi 4504697  332 PGTMRPLHVRTTSDGGYS-FKYETVPNLLTQHCAC 365
Cdd:cd13755  68 PSKLESLEVLHYDESDSSkLKVTKWKGMIVSECAC 102
TGF_beta_GDF11 cd19389
transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor ...
 254-365 8.18e-05

transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor 11 (GDF11) and similar proteins; GDF11, also termed bone morphogenetic protein 11 (BMP-11), is a secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development.


Pssm-ID: 381659  Cd Length: 109  Bit Score: 41.56  E-value: 8.18e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504697  254 EEPAAHANCHRVALNISFQELGWErWIVYPPSFIFHYCHGGCG---LHIPPNLSLpVPGAPPTPAqpysllpgAQPCCAa 330
Cdd:cd19389   7 DEHSTESRCCRYPLTVDFEAFGWD-WIIAPKRYKANYCSGQCEymfMQKYPHTHL-VQQANPRGS--------AGPCCT- 75

                        90       100       110
                ....*....|....*....|....*....|....*
gi 4504697  331 lPGTMRPLHVrTTSDGGYSFKYETVPNLLTQHCAC 365
Cdd:cd19389  76 -PTKMSPINM-LYFNDKQQIIYGKIPGMVVDRCGC 108
TGF_beta_BMP9_like cd13767
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic proteins, ...
 261-365 9.06e-05

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic proteins, BMP-9, BMP-10 and similar proteins; The family includes BMP9 (also known as GDF2) and BMP10. BMP-9 is a potent circulating inhibitor of angiogenesis. It signals through the type I activin receptor ACVRL1 but not other activin receptor-like kinases (ALKs). BMP-10 is required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. It inhibits endothelial cell migration and growth. It may reduce cell migration and cell matrix adhesion in breast cancer cell lines.


Pssm-ID: 381645  Cd Length: 105  Bit Score: 41.19  E-value: 9.06e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504697  261 NCHRVALNISFQELGWERWIVYPPSFIFHYCHGGCGLHIPPNLSlpvpgaPPTPAQPYSLLPGAQP------CCaaLPGT 334
Cdd:cd13767   2 SCRRKPLYVNFADIGWDSWIIAPKGYEAYECSGKCFFPLADHLS------PTKHAIIQTLVHSKSPekvsraCC--VPTK 73

                        90       100       110
                ....*....|....*....|....*....|....
gi 4504697  335 MRPLHVRTTSDGG---YSFKYEtvpNLLTQHCAC 365
Cdd:cd13767  74 LEPISLLYIDENGvltYKYKYE---GMVVAECGC 104
TGF_beta_ADMP cd13765
transforming growth factor beta (TGF-beta) like domain found in anti-dorsalizing morphogenetic ...
 262-328 1.27e-04

transforming growth factor beta (TGF-beta) like domain found in anti-dorsalizing morphogenetic protein (ADMP) and similar proteins; ADMP is a bone morphogenetic protein (BMP)-like transforming growth factor beta ligand, functions in the trunk organizer to antagonize head formation, thereby regulating organizer patterning. It negatively affects the formation of the organizer, although it is robustly expressed within the organizer itself. The organizer-promoting signal of ADMP is mediated by the activin A type I receptor, ACVR1 (also known as activin receptor-like kinase-2, ALK2).


Pssm-ID: 381643  Cd Length: 105  Bit Score: 40.80  E-value: 1.27e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4504697  262 CHRVALNISFQELGWERWIVYPPSFIFHYCHGGCGLHIPPNLSlpvpgapPTP-------AQPYSLLPG-AQPCC 328
Cdd:cd13765   3 CQRHELYVDFEEIGWSGWIISPKGYNAYHCKGSCPFPLGQNQK-------PTNhatvqsiVHALKLAKGvEMPCC 70
TGF_beta_GDF9 cd19403
transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor ...
 262-365 1.43e-03

transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor 9 (GDF-9) and similar proteins; GDF-9 is required for ovarian folliculogenesis. It promotes primordial follicle development and stimulates granulosa cell proliferation.


Pssm-ID: 381673  Cd Length: 106  Bit Score: 37.92  E-value: 1.43e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504697  262 CHRVALNISFQELGWERWIVYPPSFIFHYCHGGCGLHIPPNLSLPVpgapPTPAQP--YSLLPGAQPCCAALPGTMRPLH 339
Cdd:cd19403   5 CELHDFRLSFSQLKWDHWIIAPHRYNPRYCKGSCPRAVGHRYGSPV----HTMVQNiiYEKLDSSIPRPSCVPSEYNPLS 80

                        90       100
                ....*....|....*....|....*.
gi 4504697  340 VRTTSDGGySFKYETVPNLLTQHCAC 365
Cdd:cd19403  81 VLTIEPDG-SIAYKEYEDMIATKCTC 105
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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