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Conserved domains on  [gi|4504747|ref|NP_002195|]
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integrin alpha-3 preproprotein [Homo sapiens]

Protein Classification

integrin alpha( domain architecture ID 12192630)

integrin alpha forms a heterodimer with integrin beta to mediate cell-extracellular matrix and cell-cell interactions; integrin alpha is a component of integrin, a cell adhesion molecule that mediates cell-extracellular matrix and cell-cell interactions

CATH:  2.130.10.130|2.60.40.1510|2.60.40.1530|2.60.40.1460
Gene Ontology:  GO:0007155|GO:0008305|GO:0005178|GO:0046872
PubMed:  3028640|2199285|12297042|12826403|14689578|12361595|12234368
SCOP:  4003137

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Integrin_alpha2 pfam08441
Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...
 463-916 1.41e-113

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.


:

Pssm-ID: 462478 [Multi-domain]  Cd Length: 449  Bit Score: 358.94  E-value: 1.41e-113
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504747     463 RPVINIVhKTLVPRPAVLDPA--LCTAT----SCVQVELCFAYNqsaGNPNYRRNITLAYTLEADRDRRPPRLR----FA 532
Cdd:pfam08441    1 RPVVSVS-ASLQVEPNSINPEkkNCTLTgtpvSCFTVRACFSYT---GKPIPNPSLVLNYELELDRQKKKGLPPrvlfLD 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504747     533 GSESAVFHGFFSMPEMR--CQKLELLLMDNLRDKLRPIIISMNYSLplRMPDRPRLGLRSLDayPILNQAQALENHTEVQ 610
Cdd:pfam08441   77 SQQPSLTGTLVLLSQGRkvCRTTKAYLRDEFRDKLSPIVISLNYSL--RVDPRAPSDLPGLK--PILDQNQPSTVQEQAN 152

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504747     611 FQKECGPDNKCESNLQMRAAFVSEQQQKLSRLQysrDVRKLLLSINVTNTrtsersGEDAHEALLTLVVPPALLLSSVRP 690
Cdd:pfam08441  153 FLKDCGEDNVCVPDLQLSAKFDSRESDEPLLLG---DDNDLALEITVTNL------GEDAYEAELYVTLPPGLDYSGVRR 223

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504747     691 PGA-----CQANE-----TIFCELGNPFKRNQRMELLIAFEVIGVTLHTRDLQVQLQLSTSSHQD-NLWPMILTLLVDYT 759
Cdd:pfam08441  224 EGSekqlsCTAKKenstrQVVCDLGNPMKRGTQVTFGLRFSVSGLELSTEELSFDLQIRSTNEQNsNSNPVSLKVPVVAE 303

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504747     760 LQTSLSMVNHRLQsFFGGTVMGESGMK--TVEDVGSPLKYEFQVGPMGEGLVglGTLVLGLEWPYEVSNGKWLLYPTEIT 837
Cdd:pfam08441  304 AQLSLSGVSKPDQ-VVGGSVKGESAMKprSEEDIGPLVEHTYEVINNGPSTV--SGASLEISWPYELSNGKWLLYLLDVQ 380

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4504747     838 VHGNGSwpCRPPgDLINPLNLTLSDPGDRPSSPQRRRRQLDPGGGQGPPPvtlaaaKKAKSETVLTCATGrAHCVWLEC 916
Cdd:pfam08441  381 GQGKGE--CSPQ-NEINPLNLTQSLESSKPLRTSRVHHVVKRRDVLKSEK------ATQTASVLLSCDSG-ARCVVIRC 449
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 365-417 5.18e-14

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 67.40  E-value: 5.18e-14
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 4504747      365 SGSAFGLSVASIGDINQDGFQDIAVGAPFEG----LGKVYIYHSSSKGLLRQPQQVI 417
Cdd:smart00191    1 PGSYFGYSVAGVGDVNGDGYPDLLVGAPRANdageTGAVYVYFGSSGGGNSIPLQNL 57
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 304-352 4.17e-11

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 58.93  E-value: 4.17e-11
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|
gi 4504747      304 GAYFGSAIA-LADLNNDGWQDLLVGAPYYFERKEevGGAIYVFMNQAGTS 352
Cdd:smart00191    2 GSYFGYSVAgVGDVNGDGYPDLLVGAPRANDAGE--TGAVYVYFGSSGGG 49
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 48-108 2.39e-07

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 48.53  E-value: 2.39e-07
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4504747       48 PGSLFGYSVALHRQTERQQRYLLLAGAPRelavpDGYTNRTGAVYLCPLTAHKDDCERMNI 108
Cdd:smart00191    1 PGSYFGYSVAGVGDVNGDGYPDLLVGAPR-----ANDAGETGAVYVYFGSSGGGNSIPLQN 56
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 430-481 3.43e-03

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 36.58  E-value: 3.43e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 4504747      430 FGYSLSGQMDVDENFYPDLLVGS-LSDHIVLLRARPVINIVHKTLVPRPAVLD 481
Cdd:smart00191    5 FGYSVAGVGDVNGDGYPDLLVGApRANDAGETGAVYVYFGSSGGGNSIPLQNL 57
 
Name Accession Description Interval E-value
Integrin_alpha2 pfam08441
Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...
 463-916 1.41e-113

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.


Pssm-ID: 462478 [Multi-domain]  Cd Length: 449  Bit Score: 358.94  E-value: 1.41e-113
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504747     463 RPVINIVhKTLVPRPAVLDPA--LCTAT----SCVQVELCFAYNqsaGNPNYRRNITLAYTLEADRDRRPPRLR----FA 532
Cdd:pfam08441    1 RPVVSVS-ASLQVEPNSINPEkkNCTLTgtpvSCFTVRACFSYT---GKPIPNPSLVLNYELELDRQKKKGLPPrvlfLD 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504747     533 GSESAVFHGFFSMPEMR--CQKLELLLMDNLRDKLRPIIISMNYSLplRMPDRPRLGLRSLDayPILNQAQALENHTEVQ 610
Cdd:pfam08441   77 SQQPSLTGTLVLLSQGRkvCRTTKAYLRDEFRDKLSPIVISLNYSL--RVDPRAPSDLPGLK--PILDQNQPSTVQEQAN 152

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504747     611 FQKECGPDNKCESNLQMRAAFVSEQQQKLSRLQysrDVRKLLLSINVTNTrtsersGEDAHEALLTLVVPPALLLSSVRP 690
Cdd:pfam08441  153 FLKDCGEDNVCVPDLQLSAKFDSRESDEPLLLG---DDNDLALEITVTNL------GEDAYEAELYVTLPPGLDYSGVRR 223

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504747     691 PGA-----CQANE-----TIFCELGNPFKRNQRMELLIAFEVIGVTLHTRDLQVQLQLSTSSHQD-NLWPMILTLLVDYT 759
Cdd:pfam08441  224 EGSekqlsCTAKKenstrQVVCDLGNPMKRGTQVTFGLRFSVSGLELSTEELSFDLQIRSTNEQNsNSNPVSLKVPVVAE 303

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504747     760 LQTSLSMVNHRLQsFFGGTVMGESGMK--TVEDVGSPLKYEFQVGPMGEGLVglGTLVLGLEWPYEVSNGKWLLYPTEIT 837
Cdd:pfam08441  304 AQLSLSGVSKPDQ-VVGGSVKGESAMKprSEEDIGPLVEHTYEVINNGPSTV--SGASLEISWPYELSNGKWLLYLLDVQ 380

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4504747     838 VHGNGSwpCRPPgDLINPLNLTLSDPGDRPSSPQRRRRQLDPGGGQGPPPvtlaaaKKAKSETVLTCATGrAHCVWLEC 916
Cdd:pfam08441  381 GQGKGE--CSPQ-NEINPLNLTQSLESSKPLRTSRVHHVVKRRDVLKSEK------ATQTASVLLSCDSG-ARCVVIRC 449
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 365-417 5.18e-14

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 67.40  E-value: 5.18e-14
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 4504747      365 SGSAFGLSVASIGDINQDGFQDIAVGAPFEG----LGKVYIYHSSSKGLLRQPQQVI 417
Cdd:smart00191    1 PGSYFGYSVAGVGDVNGDGYPDLLVGAPRANdageTGAVYVYFGSSGGGNSIPLQNL 57
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 304-352 4.17e-11

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 58.93  E-value: 4.17e-11
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|
gi 4504747      304 GAYFGSAIA-LADLNNDGWQDLLVGAPYYFERKEevGGAIYVFMNQAGTS 352
Cdd:smart00191    2 GSYFGYSVAgVGDVNGDGYPDLLVGAPRANDAGE--TGAVYVYFGSSGGG 49
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 307-345 3.88e-09

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 52.90  E-value: 3.88e-09
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 4504747     307 FGSAIALADLNNDGWQDLLVGAPYYFERKeevGGAIYVF 345
Cdd:pfam01839    1 FGYSVAVGDLNGDGYADLAVGAPGEGGAG---AGAVYVL 36
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 369-402 2.19e-08

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 50.59  E-value: 2.19e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 4504747     369 FGLSVASiGDINQDGFQDIAVGAPFEGL---GKVYIY 402
Cdd:pfam01839    1 FGYSVAV-GDLNGDGYADLAVGAPGEGGagaGAVYVL 36
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 48-108 2.39e-07

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 48.53  E-value: 2.39e-07
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4504747       48 PGSLFGYSVALHRQTERQQRYLLLAGAPRelavpDGYTNRTGAVYLCPLTAHKDDCERMNI 108
Cdd:smart00191    1 PGSYFGYSVAGVGDVNGDGYPDLLVGAPR-----ANDAGETGAVYVYFGSSGGGNSIPLQN 56
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 430-481 3.43e-03

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 36.58  E-value: 3.43e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 4504747      430 FGYSLSGQMDVDENFYPDLLVGS-LSDHIVLLRARPVINIVHKTLVPRPAVLD 481
Cdd:smart00191    5 FGYSVAGVGDVNGDGYPDLLVGApRANDAGETGAVYVYFGSSGGGNSIPLQNL 57
 
Name Accession Description Interval E-value
Integrin_alpha2 pfam08441
Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...
 463-916 1.41e-113

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.


Pssm-ID: 462478 [Multi-domain]  Cd Length: 449  Bit Score: 358.94  E-value: 1.41e-113
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504747     463 RPVINIVhKTLVPRPAVLDPA--LCTAT----SCVQVELCFAYNqsaGNPNYRRNITLAYTLEADRDRRPPRLR----FA 532
Cdd:pfam08441    1 RPVVSVS-ASLQVEPNSINPEkkNCTLTgtpvSCFTVRACFSYT---GKPIPNPSLVLNYELELDRQKKKGLPPrvlfLD 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504747     533 GSESAVFHGFFSMPEMR--CQKLELLLMDNLRDKLRPIIISMNYSLplRMPDRPRLGLRSLDayPILNQAQALENHTEVQ 610
Cdd:pfam08441   77 SQQPSLTGTLVLLSQGRkvCRTTKAYLRDEFRDKLSPIVISLNYSL--RVDPRAPSDLPGLK--PILDQNQPSTVQEQAN 152

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504747     611 FQKECGPDNKCESNLQMRAAFVSEQQQKLSRLQysrDVRKLLLSINVTNTrtsersGEDAHEALLTLVVPPALLLSSVRP 690
Cdd:pfam08441  153 FLKDCGEDNVCVPDLQLSAKFDSRESDEPLLLG---DDNDLALEITVTNL------GEDAYEAELYVTLPPGLDYSGVRR 223

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504747     691 PGA-----CQANE-----TIFCELGNPFKRNQRMELLIAFEVIGVTLHTRDLQVQLQLSTSSHQD-NLWPMILTLLVDYT 759
Cdd:pfam08441  224 EGSekqlsCTAKKenstrQVVCDLGNPMKRGTQVTFGLRFSVSGLELSTEELSFDLQIRSTNEQNsNSNPVSLKVPVVAE 303

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504747     760 LQTSLSMVNHRLQsFFGGTVMGESGMK--TVEDVGSPLKYEFQVGPMGEGLVglGTLVLGLEWPYEVSNGKWLLYPTEIT 837
Cdd:pfam08441  304 AQLSLSGVSKPDQ-VVGGSVKGESAMKprSEEDIGPLVEHTYEVINNGPSTV--SGASLEISWPYELSNGKWLLYLLDVQ 380

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4504747     838 VHGNGSwpCRPPgDLINPLNLTLSDPGDRPSSPQRRRRQLDPGGGQGPPPvtlaaaKKAKSETVLTCATGrAHCVWLEC 916
Cdd:pfam08441  381 GQGKGE--CSPQ-NEINPLNLTQSLESSKPLRTSRVHHVVKRRDVLKSEK------ATQTASVLLSCDSG-ARCVVIRC 449
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 365-417 5.18e-14

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 67.40  E-value: 5.18e-14
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 4504747      365 SGSAFGLSVASIGDINQDGFQDIAVGAPFEG----LGKVYIYHSSSKGLLRQPQQVI 417
Cdd:smart00191    1 PGSYFGYSVAGVGDVNGDGYPDLLVGAPRANdageTGAVYVYFGSSGGGNSIPLQNL 57
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 304-352 4.17e-11

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 58.93  E-value: 4.17e-11
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|
gi 4504747      304 GAYFGSAIA-LADLNNDGWQDLLVGAPYYFERKEevGGAIYVFMNQAGTS 352
Cdd:smart00191    2 GSYFGYSVAgVGDVNGDGYPDLLVGAPRANDAGE--TGAVYVYFGSSGGG 49
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 307-345 3.88e-09

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 52.90  E-value: 3.88e-09
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 4504747     307 FGSAIALADLNNDGWQDLLVGAPYYFERKeevGGAIYVF 345
Cdd:pfam01839    1 FGYSVAVGDLNGDGYADLAVGAPGEGGAG---AGAVYVL 36
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 369-402 2.19e-08

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 50.59  E-value: 2.19e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 4504747     369 FGLSVASiGDINQDGFQDIAVGAPFEGL---GKVYIY 402
Cdd:pfam01839    1 FGYSVAV-GDLNGDGYADLAVGAPGEGGagaGAVYVL 36
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 48-108 2.39e-07

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 48.53  E-value: 2.39e-07
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4504747       48 PGSLFGYSVALHRQTERQQRYLLLAGAPRelavpDGYTNRTGAVYLCPLTAHKDDCERMNI 108
Cdd:smart00191    1 PGSYFGYSVAGVGDVNGDGYPDLLVGAPR-----ANDAGETGAVYVYFGSSGGGNSIPLQN 56
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 315-389 6.84e-07

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 47.22  E-value: 6.84e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4504747     315 DLNNDGWQDLLVGAPyyferkeevgGAIYVFMNQAGTSFPAHPSLLLHGPSGsafGLSVAsIGDINQDGFQDIAV 389
Cdd:pfam13517    1 DLDGDGKLDLVVAND----------GGLRLYLNNGDGTFTFITSVSLGGGGG---GLSVA-VGDLDGDGRLDLLV 61
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 378-450 1.70e-03

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 37.59  E-value: 1.70e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4504747     378 DINQDGFQDIAVGAPfeglGKVYIYHSSSKGLLRQPQQVIHGEKLGLPGLATFgyslsgqmDVDENFYPDLLV 450
Cdd:pfam13517    1 DLDGDGKLDLVVAND----GGLRLYLNNGDGTFTFITSVSLGGGGGGLSVAVG--------DLDGDGRLDLLV 61
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 430-481 3.43e-03

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 36.58  E-value: 3.43e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 4504747      430 FGYSLSGQMDVDENFYPDLLVGS-LSDHIVLLRARPVINIVHKTLVPRPAVLD 481
Cdd:smart00191    5 FGYSVAGVGDVNGDGYPDLLVGApRANDAGETGAVYVYFGSSGGGNSIPLQNL 57
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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