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Conserved domains on  [gi|34485722|ref|NP_002258|]
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importin subunit alpha-4 [Homo sapiens]

Protein Classification

armadillo/beta-catenin-like repeat-containing protein( domain architecture ID 1000979)

armadillo/beta-catenin-like repeat-containing protein similar to Saccharomyces cerevisiae vacuolar protein 8 that functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SRP1 super family cl34886
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
2-521 0e+00

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


The actual alignment was detected with superfamily member COG5064:

Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 519.83  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485722   2 AENPSLENHRIKSFKNKGR-DVETMRRHRNEVTVELRKNKRDEHLLKKRN-VPQEESLEDSDVDADFKAQNvTLEAILQN 79
Cdd:COG5064   1 STSRFVPEARRYNFKGKGRfSADELRRRREEQQVELRKQKREELLNKRRNlADVSEEAESSFIPMEQQFYS-ELPQLTQQ 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485722  80 ATSDNPVVQLSAVQAARKLLSSDRNPPIDDLIKSGILPILVKCLERDDNPSLQFEAAWALTNIASGTSAQTQAVVQSNAV 159
Cdd:COG5064  80 LFSDDIEQQLQAVYKFRKLLSKETSPPIQPVIDAGVVPRFVEFMDEIQRDMLQFEAAWALTNIASGTTQQTKVVVDAGAV 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485722 160 PLFLRLLRSPHQNVCEQAVWALGNIIGDGPQCRDYVISLGVVKPLLSFI-SPSIPITFLRNVTWVIVNLCRNKDPPPPME 238
Cdd:COG5064 160 PLFIQLLSSTEDDVREQAVWALGNIAGDSEGCRDYVLQCGALEPLLGLLlSSAIHISMLRNATWTLSNLCRGKNPPPDWS 239

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485722 239 TVQEILPALCVLIYHTDINILVDTVWALSYLTDGGNEQIQMVIDSGVVPFLVPLLSHQEVKVQTAALRAVGNIVTGTDEQ 318
Cdd:COG5064 240 NISQALPILAKLIYSRDPEVLVDACWAISYLSDGPNEKIQAVLDVGIPGRLVELLSHESAKIQTPALRSVGNIVTGSDDQ 319

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485722 319 TQVVLNCDVLSHFPNLLSHPKEKINKEAVWFLSNITAGNQQQVQAVIDAGLIPMIIHQLAKGDFGTQKEAAWAISNLTIS 398
Cdd:COG5064 320 TQVIINCGALKAFRSLLSSPKENIRKEACWTISNITAGNTEQIQAVIDANLIPPLIHLLSSAEYKIKKEACWAISNATSG 399

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485722 399 G--RKDQVEYLVQQNVIPPFCNLLSVKDSQVVQVVLDGLKNIL-------IMAGDEASTIAEIIEECGGLEKIEVLQQHE 469
Cdd:COG5064 400 GlnRPDIIRYLVSQGFIKPLCDLLDVVDNKIIEVALDAIENILkvgeqdrLRYGKNINIYAVYVEKAGGMDAIHGLQDSV 479

                       490       500       510       520       530
                ....*....|....*....|....*....|....*....|....*....|..
gi 34485722 470 NEDIYKLAFEIIDQYFSGDDIDEDpcLIPEaTQGGTYNFDPTANLQtkeFNF 521
Cdd:COG5064 480 NRTIYDKAYSIIEKFFGEEDAVDE--LAPE-TAGNTFTFGSNVNQQ---GNF 525
 
Name Accession Description Interval E-value
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
2-521 0e+00

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 519.83  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485722   2 AENPSLENHRIKSFKNKGR-DVETMRRHRNEVTVELRKNKRDEHLLKKRN-VPQEESLEDSDVDADFKAQNvTLEAILQN 79
Cdd:COG5064   1 STSRFVPEARRYNFKGKGRfSADELRRRREEQQVELRKQKREELLNKRRNlADVSEEAESSFIPMEQQFYS-ELPQLTQQ 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485722  80 ATSDNPVVQLSAVQAARKLLSSDRNPPIDDLIKSGILPILVKCLERDDNPSLQFEAAWALTNIASGTSAQTQAVVQSNAV 159
Cdd:COG5064  80 LFSDDIEQQLQAVYKFRKLLSKETSPPIQPVIDAGVVPRFVEFMDEIQRDMLQFEAAWALTNIASGTTQQTKVVVDAGAV 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485722 160 PLFLRLLRSPHQNVCEQAVWALGNIIGDGPQCRDYVISLGVVKPLLSFI-SPSIPITFLRNVTWVIVNLCRNKDPPPPME 238
Cdd:COG5064 160 PLFIQLLSSTEDDVREQAVWALGNIAGDSEGCRDYVLQCGALEPLLGLLlSSAIHISMLRNATWTLSNLCRGKNPPPDWS 239

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485722 239 TVQEILPALCVLIYHTDINILVDTVWALSYLTDGGNEQIQMVIDSGVVPFLVPLLSHQEVKVQTAALRAVGNIVTGTDEQ 318
Cdd:COG5064 240 NISQALPILAKLIYSRDPEVLVDACWAISYLSDGPNEKIQAVLDVGIPGRLVELLSHESAKIQTPALRSVGNIVTGSDDQ 319

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485722 319 TQVVLNCDVLSHFPNLLSHPKEKINKEAVWFLSNITAGNQQQVQAVIDAGLIPMIIHQLAKGDFGTQKEAAWAISNLTIS 398
Cdd:COG5064 320 TQVIINCGALKAFRSLLSSPKENIRKEACWTISNITAGNTEQIQAVIDANLIPPLIHLLSSAEYKIKKEACWAISNATSG 399

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485722 399 G--RKDQVEYLVQQNVIPPFCNLLSVKDSQVVQVVLDGLKNIL-------IMAGDEASTIAEIIEECGGLEKIEVLQQHE 469
Cdd:COG5064 400 GlnRPDIIRYLVSQGFIKPLCDLLDVVDNKIIEVALDAIENILkvgeqdrLRYGKNINIYAVYVEKAGGMDAIHGLQDSV 479

                       490       500       510       520       530
                ....*....|....*....|....*....|....*....|....*....|..
gi 34485722 470 NEDIYKLAFEIIDQYFSGDDIDEDpcLIPEaTQGGTYNFDPTANLQtkeFNF 521
Cdd:COG5064 480 NRTIYDKAYSIIEKFFGEEDAVDE--LAPE-TAGNTFTFGSNVNQQ---GNF 525
IBB pfam01749
Importin beta binding domain; This family consists of the importin alpha (karyopherin alpha), ...
 11-93 3.28e-30

Importin beta binding domain; This family consists of the importin alpha (karyopherin alpha), importin beta (karyopherin beta) binding domain. The domain mediates formation of the importin alpha beta complex; required for classical NLS import of proteins into the nucleus, through the nuclear pore complex and across the nuclear envelope. Also in the alignment is the NLS of importin alpha which overlaps with the IBB domain.


Pssm-ID: 460311 [Multi-domain]  Cd Length: 79  Bit Score: 112.63  E-value: 3.28e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485722    11 RIKSFKNKGRDVETMRRHRNEVTVELRKNKRDEHLLKKRNVPQEESLEDSDVDadfkAQNVTLEAILQNATSDNPVVQLS 90
Cdd:pfam01749   1 RRKSFKNKGKDADELRRRREEVQVELRKQKREEQLLKRRNVGAPSSSSSSAES----QLLESLPEMVQGVNSDDPELQLE 76


                  ...
gi 34485722    91 AVQ 93
Cdd:pfam01749  77 ATQ 79
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 274-312 9.46e-09

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 50.89  E-value: 9.46e-09
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 34485722    274 NEQIQMVIDSGVVPFLVPLLSHQEVKVQTAALRAVGNIV 312
Cdd:smart00185   2 DENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 72-186 1.38e-04

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 44.71  E-value: 1.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485722    72 TLEA-----ILQNATSDNPVVQLSAVQAARKLLSSDRNPpIDDLIKSGILPILVKCLERDDNPSLQFEAAWALTNIASGT 146
Cdd:PLN03200  185 TLEAggvdiLVKLLSSGNSDAQANAASLLARLMMAFESS-ISKVLDAGAVKQLLKLLGQGNEVSVRAEAAGALEALSSQS 263

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 34485722   147 SAQTQAVVQSNAVPLFLRLLRSPH----QNVCEQ-----AVWALGNIIG 186
Cdd:PLN03200  264 KEAKQAIADAGGIPALINATVAPSkefmQGEFAQalqenAMGALANICG 312
 
Name Accession Description Interval E-value
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
2-521 0e+00

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 519.83  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485722   2 AENPSLENHRIKSFKNKGR-DVETMRRHRNEVTVELRKNKRDEHLLKKRN-VPQEESLEDSDVDADFKAQNvTLEAILQN 79
Cdd:COG5064   1 STSRFVPEARRYNFKGKGRfSADELRRRREEQQVELRKQKREELLNKRRNlADVSEEAESSFIPMEQQFYS-ELPQLTQQ 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485722  80 ATSDNPVVQLSAVQAARKLLSSDRNPPIDDLIKSGILPILVKCLERDDNPSLQFEAAWALTNIASGTSAQTQAVVQSNAV 159
Cdd:COG5064  80 LFSDDIEQQLQAVYKFRKLLSKETSPPIQPVIDAGVVPRFVEFMDEIQRDMLQFEAAWALTNIASGTTQQTKVVVDAGAV 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485722 160 PLFLRLLRSPHQNVCEQAVWALGNIIGDGPQCRDYVISLGVVKPLLSFI-SPSIPITFLRNVTWVIVNLCRNKDPPPPME 238
Cdd:COG5064 160 PLFIQLLSSTEDDVREQAVWALGNIAGDSEGCRDYVLQCGALEPLLGLLlSSAIHISMLRNATWTLSNLCRGKNPPPDWS 239

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485722 239 TVQEILPALCVLIYHTDINILVDTVWALSYLTDGGNEQIQMVIDSGVVPFLVPLLSHQEVKVQTAALRAVGNIVTGTDEQ 318
Cdd:COG5064 240 NISQALPILAKLIYSRDPEVLVDACWAISYLSDGPNEKIQAVLDVGIPGRLVELLSHESAKIQTPALRSVGNIVTGSDDQ 319

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485722 319 TQVVLNCDVLSHFPNLLSHPKEKINKEAVWFLSNITAGNQQQVQAVIDAGLIPMIIHQLAKGDFGTQKEAAWAISNLTIS 398
Cdd:COG5064 320 TQVIINCGALKAFRSLLSSPKENIRKEACWTISNITAGNTEQIQAVIDANLIPPLIHLLSSAEYKIKKEACWAISNATSG 399

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485722 399 G--RKDQVEYLVQQNVIPPFCNLLSVKDSQVVQVVLDGLKNIL-------IMAGDEASTIAEIIEECGGLEKIEVLQQHE 469
Cdd:COG5064 400 GlnRPDIIRYLVSQGFIKPLCDLLDVVDNKIIEVALDAIENILkvgeqdrLRYGKNINIYAVYVEKAGGMDAIHGLQDSV 479

                       490       500       510       520       530
                ....*....|....*....|....*....|....*....|....*....|..
gi 34485722 470 NEDIYKLAFEIIDQYFSGDDIDEDpcLIPEaTQGGTYNFDPTANLQtkeFNF 521
Cdd:COG5064 480 NRTIYDKAYSIIEKFFGEEDAVDE--LAPE-TAGNTFTFGSNVNQQ---GNF 525
IBB pfam01749
Importin beta binding domain; This family consists of the importin alpha (karyopherin alpha), ...
 11-93 3.28e-30

Importin beta binding domain; This family consists of the importin alpha (karyopherin alpha), importin beta (karyopherin beta) binding domain. The domain mediates formation of the importin alpha beta complex; required for classical NLS import of proteins into the nucleus, through the nuclear pore complex and across the nuclear envelope. Also in the alignment is the NLS of importin alpha which overlaps with the IBB domain.


Pssm-ID: 460311 [Multi-domain]  Cd Length: 79  Bit Score: 112.63  E-value: 3.28e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485722    11 RIKSFKNKGRDVETMRRHRNEVTVELRKNKRDEHLLKKRNVPQEESLEDSDVDadfkAQNVTLEAILQNATSDNPVVQLS 90
Cdd:pfam01749   1 RRKSFKNKGKDADELRRRREEVQVELRKQKREEQLLKRRNVGAPSSSSSSAES----QLLESLPEMVQGVNSDDPELQLE 76


                  ...
gi 34485722    91 AVQ 93
Cdd:pfam01749  77 ATQ 79
Arm_3 pfam16186
Atypical Arm repeat; This atypical Arm repeat appears at the very C-terminus of eukaryotic ...
 453-499 3.43e-21

Atypical Arm repeat; This atypical Arm repeat appears at the very C-terminus of eukaryotic proteins such as importin subunit alpha-2, as the last of the repeating units.


Pssm-ID: 465050 [Multi-domain]  Cd Length: 49  Bit Score: 86.49  E-value: 3.43e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 34485722   453 IEECGGLEKIEVLQQHENEDIYKLAFEIIDQYFSGDDIDEDPCLIPE 499
Cdd:pfam16186   3 IEEAGGLDKIEALQNHENEEIYKKAYKIIEKYFSDEEEEDDENLAPE 49
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 146-184 3.24e-10

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 55.15  E-value: 3.24e-10
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 34485722   146 TSAQTQAVVQSNAVPLFLRLLRSPHQNVCEQAVWALGNI 184
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNL 39
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 129-184 9.52e-10

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 54.30  E-value: 9.52e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 34485722   129 PSLQFEAAWALTNIASGTSAQTQAVVQsNAVPLFLRLLRSPHQNVCEQAVWALGNI 184
Cdd:pfam13513   1 WRVREAAALALGSLAEGGPDLLAPAVP-ELLPALLPLLNDDSDLVREAAAWALGRL 55
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 274-313 4.25e-09

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 52.07  E-value: 4.25e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 34485722   274 NEQIQMVIDSGVVPFLVPLLSHQEVKVQTAALRAVGNIVT 313
Cdd:pfam00514   2 PENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 357-396 4.64e-09

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 52.07  E-value: 4.64e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 34485722   357 NQQQVQAVIDAGLIPMIIHQLAKGDFGTQKEAAWAISNLT 396
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 274-312 9.46e-09

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 50.89  E-value: 9.46e-09
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 34485722    274 NEQIQMVIDSGVVPFLVPLLSHQEVKVQTAALRAVGNIV 312
Cdd:smart00185   2 DENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 104-144 2.14e-08

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 50.15  E-value: 2.14e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 34485722   104 NPPIDDLIKSGILPILVKCLeRDDNPSLQFEAAWALTNIAS 144
Cdd:pfam00514   2 PENKQAVIEAGAVPPLVRLL-SSPDEEVQEEAAWALSNLAA 41
HEAT COG1413
HEAT repeat [General function prediction only];
72-184 2.56e-08

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 52.71  E-value: 2.56e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485722  72 TLEAILQNATSDNPVVQLSAVQAARKLLSSDRNPPIDDLIKSG-------------------ILPILVKCLeRDDNPSLQ 132
Cdd:COG1413  17 AVPALIAALADEDPDVRAAAARALGRLGDPRAVPALLEALKDPdpevraaaaealgrigdpeAVPALIAAL-KDEDPEVR 95

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 34485722 133 FEAAWALTNIASgtsaqtqavvqSNAVPLFLRLLRSPHQNVCEQAVWALGNI 184
Cdd:COG1413  96 RAAAEALGRLGD-----------PAAVPALLEALKDPDWEVRRAAARALGRL 136
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 146-184 2.70e-08

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 49.74  E-value: 2.70e-08
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 34485722    146 TSAQTQAVVQSNAVPLFLRLLRSPHQNVCEQAVWALGNI 184
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNL 39
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 103-144 8.99e-08

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 48.19  E-value: 8.99e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 34485722    103 RNPPIDDLIKSGILPILVKCLeRDDNPSLQFEAAWALTNIAS 144
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELL-KSEDEEVVKEAAWALSNLSS 41
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 116-184 1.60e-07

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 48.87  E-value: 1.60e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 34485722   116 LPILVKCLERDDNPSLQFEAAWALTNIASgtsaqtqavvqSNAVPLFLRLLRSPHQNVCEQAVWALGNI 184
Cdd:pfam13646   1 LPALLQALLRDPDPEVRAAAIRALGRIGD-----------PEAVPALLELLKDEDPAVRRAAAEALGKI 58
HEAT COG1413
HEAT repeat [General function prediction only];
116-311 1.76e-07

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 50.40  E-value: 1.76e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485722 116 LPILVKCLeRDDNPSLQFEAAWALTNIASGTsaqtqavvqsnAVPLFLRLLRSPHQNVCEQAVWALGNIigdgpqcrdyv 195
Cdd:COG1413  18 VPALIAAL-ADEDPDVRAAAARALGRLGDPR-----------AVPALLEALKDPDPEVRAAAAEALGRI----------- 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485722 196 islgvvkpllsfispsipitflrnvtwvivnlcrnKDPpppmetvqEILPALCVLIYHTDINILVDTVWALSYLTdggne 275
Cdd:COG1413  75 -----------------------------------GDP--------EAVPALIAALKDEDPEVRRAAAEALGRLG----- 106

                       170       180       190
                ....*....|....*....|....*....|....*.
gi 34485722 276 qiqmviDSGVVPFLVPLLSHQEVKVQTAALRAVGNI 311
Cdd:COG1413 107 ------DPAAVPALLEALKDPDWEVRRAAARALGRL 136
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 315-355 2.07e-07

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 47.06  E-value: 2.07e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 34485722   315 TDEQTQVVLNCDVLSHFPNLLSHPKEKINKEAVWFLSNITA 355
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 315-355 7.77e-07

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 45.50  E-value: 7.77e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 34485722    315 TDEQTQVVLNCDVLSHFPNLLSHPKEKINKEAVWFLSNITA 355
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 357-396 1.45e-06

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 44.73  E-value: 1.45e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 34485722    357 NQQQVQAVIDAGLIPMIIHQLAKGDFGTQKEAAWAISNLT 396
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 402-438 5.85e-05

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 40.52  E-value: 5.85e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 34485722   402 DQVEYLVQQNVIPPFCNLLSVKDSQVVQVVLDGLKNI 438
Cdd:pfam00514   3 ENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNL 39
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 72-186 1.38e-04

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 44.71  E-value: 1.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485722    72 TLEA-----ILQNATSDNPVVQLSAVQAARKLLSSDRNPpIDDLIKSGILPILVKCLERDDNPSLQFEAAWALTNIASGT 146
Cdd:PLN03200  185 TLEAggvdiLVKLLSSGNSDAQANAASLLARLMMAFESS-ISKVLDAGAVKQLLKLLGQGNEVSVRAEAAGALEALSSQS 263

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 34485722   147 SAQTQAVVQSNAVPLFLRLLRSPH----QNVCEQ-----AVWALGNIIG 186
Cdd:PLN03200  264 KEAKQAIADAGGIPALINATVAPSkefmQGEFAQalqenAMGALANICG 312
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 232-271 7.39e-04

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 37.05  E-value: 7.39e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 34485722   232 DPPPPMETVQE-ILPALCVLIYHTDINILVDTVWALSYLTD 271
Cdd:pfam00514   1 SPENKQAVIEAgAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
Adaptin_N pfam01602
Adaptin N terminal region; This family consists of the N terminal region of various alpha, ...
 75-495 7.83e-04

Adaptin N terminal region; This family consists of the N terminal region of various alpha, beta and gamma subunits of the AP-1, AP-2 and AP-3 adaptor protein complexes. The adaptor protein (AP) complexes are involved in the formation of clathrin-coated pits and vesicles. The N-terminal region of the various adaptor proteins (APs) is constant by comparison to the C-terminal which is variable within members of the AP-2 family; and it has been proposed that this constant region interacts with another uniform component of the coated vesicles.


Pssm-ID: 396262 [Multi-domain]  Cd Length: 523  Bit Score: 42.22  E-value: 7.83e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485722    75 AILQNATSDNPVVQLSAVQAARKLLSSDrnppiDDLIKSGIlPILVKCLErDDNPSlqfeaawaltniasgtsaqtqavV 154
Cdd:pfam01602 118 DIKKLLVDRSPYVRKKAALAILKLYRKS-----PDLVRDFV-PELKELLS-DKDPG-----------------------V 167

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485722   155 QSNAVPLFLRLLRSPHQNVceQAVWALGNIIGDGpqcrdyvisLGVVKPLLSfispsipITFLRnvtwVIVNLCRNkDPP 234
Cdd:pfam01602 168 QSAAVALLYEICKNDRLYL--KLLPLLFRRLCNL---------LGVLNPWLQ-------VKILR----LLTRLAPL-DPL 224

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485722   235 PPMETVQEILPalcvLIYHTDINILVDTVWALSYLtDGGNEQIQMVIDSgvvpfLVPLLSHQEVKVQTAALRAVGNIVTG 314
Cdd:pfam01602 225 LPKELLEDLLN----LLQNSNNAVLYETANTIVHL-APAPELIVLAVNA-----LGRLLSSPDENLRYVALRNLNKIVMK 294

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485722   315 TdeqTQVVLNCDVLSHFpnLLSHPKEKINKEAVWFLSNItaGNQQQVQAVIDagLIPMIIHQLAKGDFgtQKEAAWAISN 394
Cdd:pfam01602 295 E---PKAVQHLDLIIFC--LKTDDDISIRLRALDLLYAL--VNESNVKEIVK--ELLKYVHEIADPDF--KIELVRAIGR 363

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485722   395 LTI-SGRKdqveylvQQNVIPPFCNLLSVKDSQVVQVVLDGLKNILIMAgdeASTIAEIIEECgglekIEVLQQHENEDI 473
Cdd:pfam01602 364 LAEkFPTD-------AEWYLDVLLDLLSLAGSYVVDEIVEVIRDIIQNV---PELREYILEHL-----CELLEDIESPEA 428

                         410       420
                  ....*....|....*....|..
gi 34485722   474 YKLAFEIIDQYfsGDDIDEDPC 495
Cdd:pfam01602 429 LAAALWILGEY--GELIPNGSS 448
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 402-438 1.15e-03

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 36.64  E-value: 1.15e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 34485722    402 DQVEYLVQQNVIPPFCNLLSVKDSQVVQVVLDGLKNI 438
Cdd:smart00185   3 ENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNL 39
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 189-229 2.41e-03

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 35.89  E-value: 2.41e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 34485722   189 PQCRDYVISLGVVKPLLSFI-SPSIPItfLRNVTWVIVNLCR 229
Cdd:pfam00514   2 PENKQAVIEAGAVPPLVRLLsSPDEEV--QEEAAWALSNLAA 41
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 73-182 3.89e-03

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 36.55  E-value: 3.89e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34485722    73 LEAILQNATSD-NPVVQLSAVQAarklLSSDRNPpiddliksGILPILVKCLeRDDNPSLQFEAAWALTNIASgtsaqtq 151
Cdd:pfam13646   1 LPALLQALLRDpDPEVRAAAIRA----LGRIGDP--------EAVPALLELL-KDEDPAVRRAAAEALGKIGD------- 60

                          90       100       110
                  ....*....|....*....|....*....|..
gi 34485722   152 avvqSNAVPLFLRLLRS-PHQNVCEQAVWALG 182
Cdd:pfam13646  61 ----PEALPALLELLRDdDDDVVRAAAAEALA 88
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 263-311 5.61e-03

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 35.04  E-value: 5.61e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 34485722   263 VWALSYLTDGGNEQIQMVIDSgVVPFLVPLLSHQEVKVQTAALRAVGNI 311
Cdd:pfam13513   8 ALALGSLAEGGPDLLAPAVPE-LLPALLPLLNDDSDLVREAAAWALGRL 55
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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