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Conserved domains on  [gi|94538366|ref|NP_002411|]
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transient receptor potential cation channel subfamily M member 1 isoform 2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LSDAT_euk pfam18139
SLOG in TRPM; Family in the SLOG superfamily, found in several eukaryotic channels including ...
 70-335 1.12e-161

SLOG in TRPM; Family in the SLOG superfamily, found in several eukaryotic channels including diverse ciliate channels and the TRPM class of animal ion channels. Positioned near the N-terminus of all TRPM channels, it is predicted to play a regulatory role for the channel in potentially recognizing a universal nucleotide or nucleotide-derived ligand.


:

Pssm-ID: 465665  Cd Length: 266  Bit Score: 489.78  E-value: 1.12e-161
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94538366     70 AMYIRVSYDTKPDSLLHLMVKDWQLELPKLLISVHGGLQNFEMQPKLKQVFGKGLIKAAMTTGAWIFTGGVSTGVISHVG 149
Cdd:pfam18139    1 AKYIRLSFDTDPEDLLHLMEKEWQLELPKLVISVHGGATNFELQPKLKRVFRKGLLKAAKTTGAWIITGGTNTGVMRHVG 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94538366    150 DALKDHSSKSRGRVCAIGIAPWGIVENKEDLVGKDVTRVYQTMSNPLSKLSVLNNSHTHFILADNGTLGKYGAEVKLRRL 229
Cdd:pfam18139   81 DALKDLGSQSRRKIVTIGIAPWGIIKNREDLIGKDVVVPYQTLGNPKSKLAVLNNNHSHFLLVDDGTVGKYGAEIILRRR 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94538366    230 LEKHISLQKINTRLGQGVPLVGLVVEGGPNVVSIVLEYLQEEPPIPVVICDGSGRASDILSFAHKYCEEGGIINESLREQ 309
Cdd:pfam18139  161 LEKYISQQKIHPRGGQGVPVVCVVVEGGPNTIKTVLEYVRDTPPVPVVVCDGSGRAADLLAFAHKYTHEDGQLPSSVKEQ 240

                          250       260
                   ....*....|....*....|....*.
gi 94538366    310 LLVTIQKTFNYNKAQSHQLFAIIMEC 335
Cdd:pfam18139  241 LLSLIQKTFGYSQKQAEKLLKQLMEC 266
TRPM_tetra pfam16519
tetramerization domain of TRPM; TRPM7_tetra is a short anti-parallel coiled-coil ...
 1179-1234 2.35e-23

tetramerization domain of TRPM; TRPM7_tetra is a short anti-parallel coiled-coil tetramerization domain of the transient receptor potential cation channel subfamily M member proteins 1-8. It is held together by extensive core packing and interstrand polar interactions. Transient receptor potential (TRP) channels comprise a large family of tetrameric cation-selective ion channels that respond to diverse forms of sensory input. The presence of cytoplasmic domains that direct channel assembly appears to be a feature of many voltage-gated ion channel superfamily members.


:

Pssm-ID: 465156  Cd Length: 56  Bit Score: 94.32  E-value: 2.35e-23
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 94538366   1179 DERIRVTSERVENMSMRLEEINERETFMKTSLQTVDLRLAQLEELSNRMVNALENL 1234
Cdd:pfam16519    1 DERIRVTTERVENMSMKVEEVNEKENFQKASLQSLDFRLGKLEDLSAQTVDTLSVL 56
TRPV super family cl40437
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ...
 712-1110 3.11e-23

Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).


The actual alignment was detected with superfamily member TIGR00870:

Pssm-ID: 454755 [Multi-domain]  Cd Length: 743  Bit Score: 107.09  E-value: 3.11e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94538366    712 LKLAVAAKHRDFIAHTCSQMLLTDMWMGRL-RMRKNPGLKVIMGIllppTILFLEFRTYDDFsYQTSKENEDGKEKeeen 790
Cdd:TIGR00870  275 LKLAIKYKQKKFVAWPNGQQLLSLYWLEELdGWRRKQSVLELIVV----FVIGLKFPELSDM-YLIAPLSRLGQFK---- 345

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94538366    791 tdanadagsRKgdeenehkkqrsipigtkicefynaPIVKFWFYTISYLG--YLLLFN---YVILVRMDGW-----PSLQ 860
Cdd:TIGR00870  346 ---------WK-------------------------PFIKFIFHSASYLYflYLIIFTsvaYYRPTRTDLRvtglqQTPL 391

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94538366    861 EWIVISYIVSLALEKIREILMsepgklsQKIKVWLQEYWNITDLVAISTFMIG------AILRLQNQPYM---------- 924
Cdd:TIGR00870  392 EMLIVTWVDGLRLGEEKLIWL-------GGIFEYIHQLWNILDFGMNSFYLATfldrpfAILFVTQAFLVlrehwlrfdp 464

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94538366    925 --GYgRVIYCVDIIFWYIRVLDIFGVNKYLGPYVMMIGKMMI-DMLYFVVIMLVVLMSFGVARQAILH---PEEKPSWKL 998
Cdd:TIGR00870  465 tlIE-EALFAFALVLSWLNLLYIFRGNQHLGPLQIMIGRMILgDILRFLFIYAVVLFGFACGLNQLYQyydELKLNECSN 543

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94538366    999 ARNIFYMPYWMIYGEVFADQIDLYAMEINppcGENLYDEEGKRLPpcipgaWLTPALMACYLLVANILLVNLLIAVFNNT 1078
Cdd:TIGR00870  544 PHARSCEKQGNAYSTLFETSQELFWAIIG---LGDLLANEHKFTE------FVGLLLFGAYNVIMYILLLNMLIAMMGNT 614

                          410       420       430
                   ....*....|....*....|....*....|...
gi 94538366   1079 FFEVKSISNQVWKFQRYQLIM-TFHDRPVLPPP 1110
Cdd:TIGR00870  615 YQLIADDADEEWKFQRAKLWMsYEREGGTCPPP 647
 
Name Accession Description Interval E-value
LSDAT_euk pfam18139
SLOG in TRPM; Family in the SLOG superfamily, found in several eukaryotic channels including ...
 70-335 1.12e-161

SLOG in TRPM; Family in the SLOG superfamily, found in several eukaryotic channels including diverse ciliate channels and the TRPM class of animal ion channels. Positioned near the N-terminus of all TRPM channels, it is predicted to play a regulatory role for the channel in potentially recognizing a universal nucleotide or nucleotide-derived ligand.


Pssm-ID: 465665  Cd Length: 266  Bit Score: 489.78  E-value: 1.12e-161
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94538366     70 AMYIRVSYDTKPDSLLHLMVKDWQLELPKLLISVHGGLQNFEMQPKLKQVFGKGLIKAAMTTGAWIFTGGVSTGVISHVG 149
Cdd:pfam18139    1 AKYIRLSFDTDPEDLLHLMEKEWQLELPKLVISVHGGATNFELQPKLKRVFRKGLLKAAKTTGAWIITGGTNTGVMRHVG 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94538366    150 DALKDHSSKSRGRVCAIGIAPWGIVENKEDLVGKDVTRVYQTMSNPLSKLSVLNNSHTHFILADNGTLGKYGAEVKLRRL 229
Cdd:pfam18139   81 DALKDLGSQSRRKIVTIGIAPWGIIKNREDLIGKDVVVPYQTLGNPKSKLAVLNNNHSHFLLVDDGTVGKYGAEIILRRR 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94538366    230 LEKHISLQKINTRLGQGVPLVGLVVEGGPNVVSIVLEYLQEEPPIPVVICDGSGRASDILSFAHKYCEEGGIINESLREQ 309
Cdd:pfam18139  161 LEKYISQQKIHPRGGQGVPVVCVVVEGGPNTIKTVLEYVRDTPPVPVVVCDGSGRAADLLAFAHKYTHEDGQLPSSVKEQ 240

                          250       260
                   ....*....|....*....|....*.
gi 94538366    310 LLVTIQKTFNYNKAQSHQLFAIIMEC 335
Cdd:pfam18139  241 LLSLIQKTFGYSQKQAEKLLKQLMEC 266
TRPM_tetra pfam16519
tetramerization domain of TRPM; TRPM7_tetra is a short anti-parallel coiled-coil ...
 1179-1234 2.35e-23

tetramerization domain of TRPM; TRPM7_tetra is a short anti-parallel coiled-coil tetramerization domain of the transient receptor potential cation channel subfamily M member proteins 1-8. It is held together by extensive core packing and interstrand polar interactions. Transient receptor potential (TRP) channels comprise a large family of tetrameric cation-selective ion channels that respond to diverse forms of sensory input. The presence of cytoplasmic domains that direct channel assembly appears to be a feature of many voltage-gated ion channel superfamily members.


Pssm-ID: 465156  Cd Length: 56  Bit Score: 94.32  E-value: 2.35e-23
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 94538366   1179 DERIRVTSERVENMSMRLEEINERETFMKTSLQTVDLRLAQLEELSNRMVNALENL 1234
Cdd:pfam16519    1 DERIRVTTERVENMSMKVEEVNEKENFQKASLQSLDFRLGKLEDLSAQTVDTLSVL 56
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 712-1110 3.11e-23

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 107.09  E-value: 3.11e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94538366    712 LKLAVAAKHRDFIAHTCSQMLLTDMWMGRL-RMRKNPGLKVIMGIllppTILFLEFRTYDDFsYQTSKENEDGKEKeeen 790
Cdd:TIGR00870  275 LKLAIKYKQKKFVAWPNGQQLLSLYWLEELdGWRRKQSVLELIVV----FVIGLKFPELSDM-YLIAPLSRLGQFK---- 345

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94538366    791 tdanadagsRKgdeenehkkqrsipigtkicefynaPIVKFWFYTISYLG--YLLLFN---YVILVRMDGW-----PSLQ 860
Cdd:TIGR00870  346 ---------WK-------------------------PFIKFIFHSASYLYflYLIIFTsvaYYRPTRTDLRvtglqQTPL 391

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94538366    861 EWIVISYIVSLALEKIREILMsepgklsQKIKVWLQEYWNITDLVAISTFMIG------AILRLQNQPYM---------- 924
Cdd:TIGR00870  392 EMLIVTWVDGLRLGEEKLIWL-------GGIFEYIHQLWNILDFGMNSFYLATfldrpfAILFVTQAFLVlrehwlrfdp 464

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94538366    925 --GYgRVIYCVDIIFWYIRVLDIFGVNKYLGPYVMMIGKMMI-DMLYFVVIMLVVLMSFGVARQAILH---PEEKPSWKL 998
Cdd:TIGR00870  465 tlIE-EALFAFALVLSWLNLLYIFRGNQHLGPLQIMIGRMILgDILRFLFIYAVVLFGFACGLNQLYQyydELKLNECSN 543

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94538366    999 ARNIFYMPYWMIYGEVFADQIDLYAMEINppcGENLYDEEGKRLPpcipgaWLTPALMACYLLVANILLVNLLIAVFNNT 1078
Cdd:TIGR00870  544 PHARSCEKQGNAYSTLFETSQELFWAIIG---LGDLLANEHKFTE------FVGLLLFGAYNVIMYILLLNMLIAMMGNT 614

                          410       420       430
                   ....*....|....*....|....*....|...
gi 94538366   1079 FFEVKSISNQVWKFQRYQLIM-TFHDRPVLPPP 1110
Cdd:TIGR00870  615 YQLIADDADEEWKFQRAKLWMsYEREGGTCPPP 647
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 831-1084 1.59e-18

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 86.55  E-value: 1.59e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94538366    831 FWFYtisYLGYLLLFNYVILVRMDGWP-------SLQEWIVISYIVSLALEKIREILMSEPgklsqkIKVWLQEYWNITD 903
Cdd:pfam00520    2 RYFE---LFILLLILLNTIFLALETYFqpeepltTVLEILDYVFTGIFTLEMLLKIIAAGF------KKRYFRSPWNILD 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94538366    904 LVAISTFMIGAILRLQNQPYMGygRVIycvdIIFWYIRVLDIFGVNKYLGPYVMMIGKMMIDMLYFVVIMLVVLMSFGVA 983
Cdd:pfam00520   73 FVVVLPSLISLVLSSVGSLSGL--RVL----RLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAII 146

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94538366    984 RQAILHPEEKpSWKLARNIFYMpyWMIYGEVFadqidLYAMEINppCGENLYDEegkrLPPCIP--GAWLTPALMACYLL 1061
Cdd:pfam00520  147 GYQLFGGKLK-TWENPDNGRTN--FDNFPNAF-----LWLFQTM--TTEGWGDI----MYDTIDgkGEFWAYIYFVSFII 212

                          250       260
                   ....*....|....*....|...
gi 94538366   1062 VANILLVNLLIAVFNNTFFEVKS 1084
Cdd:pfam00520  213 LGGFLLLNLFIAVIIDNFQELTE 235
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 950-1093 5.35e-09

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 60.80  E-value: 5.35e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94538366  950 KYLGPYVMMIGKMMI-DMLYFVVIMLVVLMSFGVARQAILHPEEkPSWklarnifyMPYWMIYGEVFADQIDLYAMEINP 1028
Cdd:cd22192  445 QMLGPFTIMIQKIIFgDLMKFCWLMFVVILGFSSAFYMIFQTED-PDS--------LGHFYDFPMTLFSTFELFLGLIDG 515

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 94538366 1029 PcgenlydeegkrLPPCIPGAWLTPALMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQ 1093
Cdd:cd22192  516 P------------ANYTVDLPFMYKVLYTAFAVIAYLLMLNLLIAMMGDTHWRVAHERDELWRAQ 568
 
Name Accession Description Interval E-value
LSDAT_euk pfam18139
SLOG in TRPM; Family in the SLOG superfamily, found in several eukaryotic channels including ...
 70-335 1.12e-161

SLOG in TRPM; Family in the SLOG superfamily, found in several eukaryotic channels including diverse ciliate channels and the TRPM class of animal ion channels. Positioned near the N-terminus of all TRPM channels, it is predicted to play a regulatory role for the channel in potentially recognizing a universal nucleotide or nucleotide-derived ligand.


Pssm-ID: 465665  Cd Length: 266  Bit Score: 489.78  E-value: 1.12e-161
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94538366     70 AMYIRVSYDTKPDSLLHLMVKDWQLELPKLLISVHGGLQNFEMQPKLKQVFGKGLIKAAMTTGAWIFTGGVSTGVISHVG 149
Cdd:pfam18139    1 AKYIRLSFDTDPEDLLHLMEKEWQLELPKLVISVHGGATNFELQPKLKRVFRKGLLKAAKTTGAWIITGGTNTGVMRHVG 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94538366    150 DALKDHSSKSRGRVCAIGIAPWGIVENKEDLVGKDVTRVYQTMSNPLSKLSVLNNSHTHFILADNGTLGKYGAEVKLRRL 229
Cdd:pfam18139   81 DALKDLGSQSRRKIVTIGIAPWGIIKNREDLIGKDVVVPYQTLGNPKSKLAVLNNNHSHFLLVDDGTVGKYGAEIILRRR 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94538366    230 LEKHISLQKINTRLGQGVPLVGLVVEGGPNVVSIVLEYLQEEPPIPVVICDGSGRASDILSFAHKYCEEGGIINESLREQ 309
Cdd:pfam18139  161 LEKYISQQKIHPRGGQGVPVVCVVVEGGPNTIKTVLEYVRDTPPVPVVVCDGSGRAADLLAFAHKYTHEDGQLPSSVKEQ 240

                          250       260
                   ....*....|....*....|....*.
gi 94538366    310 LLVTIQKTFNYNKAQSHQLFAIIMEC 335
Cdd:pfam18139  241 LLSLIQKTFGYSQKQAEKLLKQLMEC 266
TRPM_tetra pfam16519
tetramerization domain of TRPM; TRPM7_tetra is a short anti-parallel coiled-coil ...
 1179-1234 2.35e-23

tetramerization domain of TRPM; TRPM7_tetra is a short anti-parallel coiled-coil tetramerization domain of the transient receptor potential cation channel subfamily M member proteins 1-8. It is held together by extensive core packing and interstrand polar interactions. Transient receptor potential (TRP) channels comprise a large family of tetrameric cation-selective ion channels that respond to diverse forms of sensory input. The presence of cytoplasmic domains that direct channel assembly appears to be a feature of many voltage-gated ion channel superfamily members.


Pssm-ID: 465156  Cd Length: 56  Bit Score: 94.32  E-value: 2.35e-23
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 94538366   1179 DERIRVTSERVENMSMRLEEINERETFMKTSLQTVDLRLAQLEELSNRMVNALENL 1234
Cdd:pfam16519    1 DERIRVTTERVENMSMKVEEVNEKENFQKASLQSLDFRLGKLEDLSAQTVDTLSVL 56
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 712-1110 3.11e-23

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 107.09  E-value: 3.11e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94538366    712 LKLAVAAKHRDFIAHTCSQMLLTDMWMGRL-RMRKNPGLKVIMGIllppTILFLEFRTYDDFsYQTSKENEDGKEKeeen 790
Cdd:TIGR00870  275 LKLAIKYKQKKFVAWPNGQQLLSLYWLEELdGWRRKQSVLELIVV----FVIGLKFPELSDM-YLIAPLSRLGQFK---- 345

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94538366    791 tdanadagsRKgdeenehkkqrsipigtkicefynaPIVKFWFYTISYLG--YLLLFN---YVILVRMDGW-----PSLQ 860
Cdd:TIGR00870  346 ---------WK-------------------------PFIKFIFHSASYLYflYLIIFTsvaYYRPTRTDLRvtglqQTPL 391

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94538366    861 EWIVISYIVSLALEKIREILMsepgklsQKIKVWLQEYWNITDLVAISTFMIG------AILRLQNQPYM---------- 924
Cdd:TIGR00870  392 EMLIVTWVDGLRLGEEKLIWL-------GGIFEYIHQLWNILDFGMNSFYLATfldrpfAILFVTQAFLVlrehwlrfdp 464

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94538366    925 --GYgRVIYCVDIIFWYIRVLDIFGVNKYLGPYVMMIGKMMI-DMLYFVVIMLVVLMSFGVARQAILH---PEEKPSWKL 998
Cdd:TIGR00870  465 tlIE-EALFAFALVLSWLNLLYIFRGNQHLGPLQIMIGRMILgDILRFLFIYAVVLFGFACGLNQLYQyydELKLNECSN 543

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94538366    999 ARNIFYMPYWMIYGEVFADQIDLYAMEINppcGENLYDEEGKRLPpcipgaWLTPALMACYLLVANILLVNLLIAVFNNT 1078
Cdd:TIGR00870  544 PHARSCEKQGNAYSTLFETSQELFWAIIG---LGDLLANEHKFTE------FVGLLLFGAYNVIMYILLLNMLIAMMGNT 614

                          410       420       430
                   ....*....|....*....|....*....|...
gi 94538366   1079 FFEVKSISNQVWKFQRYQLIM-TFHDRPVLPPP 1110
Cdd:TIGR00870  615 YQLIADDADEEWKFQRAKLWMsYEREGGTCPPP 647
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 831-1084 1.59e-18

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 86.55  E-value: 1.59e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94538366    831 FWFYtisYLGYLLLFNYVILVRMDGWP-------SLQEWIVISYIVSLALEKIREILMSEPgklsqkIKVWLQEYWNITD 903
Cdd:pfam00520    2 RYFE---LFILLLILLNTIFLALETYFqpeepltTVLEILDYVFTGIFTLEMLLKIIAAGF------KKRYFRSPWNILD 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94538366    904 LVAISTFMIGAILRLQNQPYMGygRVIycvdIIFWYIRVLDIFGVNKYLGPYVMMIGKMMIDMLYFVVIMLVVLMSFGVA 983
Cdd:pfam00520   73 FVVVLPSLISLVLSSVGSLSGL--RVL----RLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAII 146

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94538366    984 RQAILHPEEKpSWKLARNIFYMpyWMIYGEVFadqidLYAMEINppCGENLYDEegkrLPPCIP--GAWLTPALMACYLL 1061
Cdd:pfam00520  147 GYQLFGGKLK-TWENPDNGRTN--FDNFPNAF-----LWLFQTM--TTEGWGDI----MYDTIDgkGEFWAYIYFVSFII 212

                          250       260
                   ....*....|....*....|...
gi 94538366   1062 VANILLVNLLIAVFNNTFFEVKS 1084
Cdd:pfam00520  213 LGGFLLLNLFIAVIIDNFQELTE 235
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 950-1093 5.35e-09

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 60.80  E-value: 5.35e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94538366  950 KYLGPYVMMIGKMMI-DMLYFVVIMLVVLMSFGVARQAILHPEEkPSWklarnifyMPYWMIYGEVFADQIDLYAMEINP 1028
Cdd:cd22192  445 QMLGPFTIMIQKIIFgDLMKFCWLMFVVILGFSSAFYMIFQTED-PDS--------LGHFYDFPMTLFSTFELFLGLIDG 515

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 94538366 1029 PcgenlydeegkrLPPCIPGAWLTPALMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQ 1093
Cdd:cd22192  516 P------------ANYTVDLPFMYKVLYTAFAVIAYLLMLNLLIAMMGDTHWRVAHERDELWRAQ 568
TRPV cd21882
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ...
 950-1094 3.29e-08

Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).


Pssm-ID: 411975 [Multi-domain]  Cd Length: 600  Bit Score: 58.35  E-value: 3.29e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94538366  950 KYLGPYVMMIGKMMI-DMLYFVVIMLVVLMSFGVARQAILHPEEKPSWKLARNIfYMPYWMIYgEVFADQIDLyameinp 1028
Cdd:cd21882  430 QMLGIYTVMIQKMILrDLMRFCWVYLVFLFGFASAFVILFQTEDPNKLGEFRDY-PDALLELF-KFTIGMGDL------- 500

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 94538366 1029 PCGENlYDeegkrlppcIPGAWLTpaLMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQR 1094
Cdd:cd21882  501 PFNEN-VD---------FPFVYLI--LLLAYVILTYLLLLNMLIALMGETVNRVAQESDEIWKLQK 554
TRPV1-4 cd22193
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 1-4; TRPV1-4 are ...
 829-1101 2.47e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 1-4; TRPV1-4 are thermo-sensing channels that function directly in temperature-sensing and nociception; they share substantial structural and functional properties. Transient Receptor Potential (TRP) ion channels activated by temperature (thermo TRPs) are important molecular players in acute, inflammatory, and chronic pain states. So far, 11 TRP channels in mammalian cells have been identified as thermosensitive TRP (thermo-TRP) channels. TRPV1-4 channels are activated by different heat temperatures, for example, TRPV1 and TRPV2 are activated by high temperatures (>43C and >55C, respectively). TRPV1-4 belong to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411977 [Multi-domain]  Cd Length: 607  Bit Score: 52.10  E-value: 2.47e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94538366  829 VKFWFYTISYLGYLLLFNYVILVR-MDGWPS--------------LQEWIVISYIVSLALEKIREILMSEPGKLSQKIKV 893
Cdd:cd22193  306 YMFFFSFCFYLFYMIIFTLVAYYRpREDEPPpplakttkmdymrlLGEILVLLGGVYFFVKEIAYFLLRRSDLQSSFSDS 385

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94538366  894 WLQEYWNITDLVAIstfmIGAILRL-QNQPY---------MGYGRVIYcvdiifwYIRVLdifgvnKYLGPYVMMIGKMM 963
Cdd:cd22193  386 YFEILFFVQAVLVI----LSVVLYLfAYKEYlaclvlalaLGWANMLY-------YTRGF------QSMGIYSVMIQKVI 448

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94538366  964 I-DMLYFVVIMLVVLMSFGVARQAILHPEEKPSWKLArnifymPYWMIYGEVfadqIDLYAMEINppCGENLYDEEGKrl 1042
Cdd:cd22193  449 LrDLLRFLFVYLLFLFGFAVALVSLIEKCSSDKKDCS------SYGSFSDAV----LELFKLTIG--MGDLEFQENST-- 514

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 94538366 1043 ppcIPGAWLTpaLMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTF 1101
Cdd:cd22193  515 ---YPAVFLI--LLLTYVILTFVLLLNMLIALMGETVNNVSKESKRIWKLQRAITILEF 568
TRPV1 cd22196
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 1; Vanilloid receptor 1 ...
 950-1094 8.86e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 1; Vanilloid receptor 1 (TRPV1), a capsaicin (vanilloid) receptor, is the founding member of the vanilloid TRP subfamily (TRPV). In humans, it is expressed in the brain, kidney, pancreas, testis, uterus, spleen, stomach, small intestine, lung and liver. TRPV1 has been implicated to have function in thermo-sensation (heat), autonomic thermoregulation, nociception, food intake regulation, and multiple functions in the gastrointestinal (GI) tract. The receptor has also been involved in growth cone guidance, long-term depression, endocannabinoid signaling and osmosensing in the central nervous system. TRPV1 is up regulated in several human pathological conditions including vulvodynia, GI inflammation, Crohn's disease and ulcerative colitis. TRPV1 knock-out mice exhibit impaired sensation to thermal-mechanical acute pain. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411980 [Multi-domain]  Cd Length: 649  Bit Score: 50.57  E-value: 8.86e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94538366  950 KYLGPYVMMIGKMMI-DMLYFVVIMLVVLMSFGVARQAILhpEEKPSWKLARNIFYM----PYWMIYGEVFADQIDLYAM 1024
Cdd:cd22196  452 QQMGIYSVMIQKMILrDICRFLFVYLVFLFGFSAALVTLI--EDGPPKGDVNTSQKEcvckSGYNSYNSLYSTCLELFKF 529

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94538366 1025 EINppCGENLYDEEGKRLPPCIpgawltpALMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQR 1094
Cdd:cd22196  530 TIG--MGDLEFTENYKFKEVFI-------FLLISYVILTYILLLNMLIALMGETVSKIAQESKNIWKLQR 590
TRPV3 cd22194
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a ...
 952-1109 1.62e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a temperature-sensitive Transient Receptor Potential (TRP) ion channel that is activated by warm temperatures, synthetic small-molecule chemicals, and natural compounds from plants. TRPV3 function is regulated by physiological factors such as extracellular divalent cations and acidic pH, intracellular adenosine triphosphate, membrane voltage, and arachidonic acid. It is expressed in both neuronal and non-neuronal tissues including epidermal keratinocytes, epithelial cells in the gut, endothelial cells in blood vessels, and neurons in dorsal root ganglia and CNS. TRPV3 null mice have abnormal hair morphogenesis and compromised skin barrier function. It may play roles in inflammatory skin disorders, such as itch and pain sensation. TRPV3 is also expressed by many neuronal and non-neuronal tissues, showing that TRPV3 might play roles in other unknown cellular and physiological functions. TRPV3 belongs to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411978 [Multi-domain]  Cd Length: 680  Bit Score: 49.76  E-value: 1.62e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94538366  952 LGPYVMMIGKMMI-DMLYFVVIMLVVLMSFGVARQAILH-----PEEKPSWKLARNIFympywmiygEVFADQIDLYAME 1025
Cdd:cd22194  498 LGIYSVMIQKVILnDVLKFLLVYILFLLGFGVALASLIEdcpddSECSSYGSFSDAVL---------ELFKLTIGLGDLE 568

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94538366 1026 InppcgenlyDEEGKrlppcIPGAWLtpALMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHDRp 1105
Cdd:cd22194  569 I---------QQNSK-----YPILFL--LLLITYVILTFVLLLNMLIALMGETVENVSKESERIWRLQRARTILEFEKS- 631


                 ....
gi 94538366 1106 vLPP 1109
Cdd:cd22194  632 -LPE 634
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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