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Conserved domains on  [gi|23111009|ref|NP_002469|]
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myoblast determination protein 1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
BASIC smart00520
Basic domain in HLH proteins of MYOD family;
19-114 8.04e-39

Basic domain in HLH proteins of MYOD family;


:

Pssm-ID: 128794  Cd Length: 91  Bit Score: 132.19  E-value: 8.04e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23111009     19 SLCSFATTDDFYDDPCFDSPDLRFFEDLDPR-LMHVGALLKpeehshfpaavHPAPGAREDEHVRAPSGHHQAGRCLLWA 97
Cdd:smart00520   6 TNCYFFPSQRFYDGDCFPSPDLGFFEDLGPReLGHCGALLK-----------DELRGSEEEEHVRAPSGHHQPGQCLPWA 74
                           90
                   ....*....|....*..
gi 23111009     98 CKACKRKTTNADRRKAA 114
Cdd:smart00520  75 CKACKRKSVTMDRRKAA 91
bHLH_TS_MYOD1_Myf3 cd18936
basic helix-loop-helix (bHLH) domain found in myoblast determination protein 1 (MYOD1) and ...
105-165 4.19e-38

basic helix-loop-helix (bHLH) domain found in myoblast determination protein 1 (MYOD1) and similar proteins; MYOD1, also termed Class C basic helix-loop-helix protein 1 (bHLHc1), or myogenic factor 3 (Myf-3), is a bHLH transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with Myf-5 and MYOG, MYOD1 co-occupies muscle-specific gene promoter core region during myogenesis.


:

Pssm-ID: 381506  Cd Length: 61  Bit Score: 129.79  E-value: 4.19e-38
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 23111009 105 TTNADRRKAATMRERRRLSKVNEAFETLKRCTSSNPNQRLPKVEILRNAIRYIEGLQALLR 165
Cdd:cd18936   1 TTNADRRKAATMRERRRLSKVNEAFETLKRCTSTNPNQRLPKVEILRNAIRYIESLQALLR 61
Myf5 pfam12232
Myogenic determination factor 5; This domain family is found in eukaryotes, and is ...
191-259 1.21e-27

Myogenic determination factor 5; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The family is found in association with pfam00010, pfam01586. There is a conserved CSD sequence motif. Myf5 is responsible for directing cells to the skeletal myocyte lineage during development. Myf5 is likely to act in a similar way to the other MRF4 proteins such as MyoD which perform the same function. These are histone acetyltransferases and histone deacetylases which activate and repress genes involved in the myocyte lineage.


:

Pssm-ID: 463500  Cd Length: 71  Bit Score: 102.44  E-value: 1.21e-27
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 23111009   191 EHY---SGDSDASSPRSNCSDGMMDYSGPPSGARRRNcYEGAYYNEAPSEPRPGKSAAVSSLDCLSSIVERI 259
Cdd:pfam12232   1 ENYyglSSDSEASSPRSNCSDGMMDCNSPVWSSRNSS-FSSSYCSDLPNGSSSSKSSVVSSLDCLSSIVDRI 71
 
Name Accession Description Interval E-value
BASIC smart00520
Basic domain in HLH proteins of MYOD family;
19-114 8.04e-39

Basic domain in HLH proteins of MYOD family;


Pssm-ID: 128794  Cd Length: 91  Bit Score: 132.19  E-value: 8.04e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23111009     19 SLCSFATTDDFYDDPCFDSPDLRFFEDLDPR-LMHVGALLKpeehshfpaavHPAPGAREDEHVRAPSGHHQAGRCLLWA 97
Cdd:smart00520   6 TNCYFFPSQRFYDGDCFPSPDLGFFEDLGPReLGHCGALLK-----------DELRGSEEEEHVRAPSGHHQPGQCLPWA 74
                           90
                   ....*....|....*..
gi 23111009     98 CKACKRKTTNADRRKAA 114
Cdd:smart00520  75 CKACKRKSVTMDRRKAA 91
bHLH_TS_MYOD1_Myf3 cd18936
basic helix-loop-helix (bHLH) domain found in myoblast determination protein 1 (MYOD1) and ...
105-165 4.19e-38

basic helix-loop-helix (bHLH) domain found in myoblast determination protein 1 (MYOD1) and similar proteins; MYOD1, also termed Class C basic helix-loop-helix protein 1 (bHLHc1), or myogenic factor 3 (Myf-3), is a bHLH transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with Myf-5 and MYOG, MYOD1 co-occupies muscle-specific gene promoter core region during myogenesis.


Pssm-ID: 381506  Cd Length: 61  Bit Score: 129.79  E-value: 4.19e-38
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 23111009 105 TTNADRRKAATMRERRRLSKVNEAFETLKRCTSSNPNQRLPKVEILRNAIRYIEGLQALLR 165
Cdd:cd18936   1 TTNADRRKAATMRERRRLSKVNEAFETLKRCTSTNPNQRLPKVEILRNAIRYIESLQALLR 61
Basic pfam01586
Myogenic Basic domain; This basic domain is found in the MyoD family of muscle specific ...
27-109 7.75e-31

Myogenic Basic domain; This basic domain is found in the MyoD family of muscle specific proteins that control muscle development. The bHLH region of the MyoD family includes the basic domain and the Helix-loop-helix (HLH) motif. The bHLH region mediates specific DNA binding. With 12 residues of the basic domain involved in DNA binding. The basic domain forms an extended alpha helix in the structure.


Pssm-ID: 460258  Cd Length: 81  Bit Score: 111.35  E-value: 7.75e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23111009    27 DDFYDDPCFDSPDLRFFEDLD-PRLMHVGALLKPEEHSHFPAAVHPAPGareDEHVRAPSGHHQAGRCLLWACKACKRKT 105
Cdd:pfam01586   1 MELYETNCYFFPDQRFYEDGEnPRLQGYDQALYQPRESPSLCGDGRAAG---EEHVRAPPGHHCPGQCLPWACKACKRKS 77

                  ....
gi 23111009   106 TNAD 109
Cdd:pfam01586  78 VTMD 81
Myf5 pfam12232
Myogenic determination factor 5; This domain family is found in eukaryotes, and is ...
191-259 1.21e-27

Myogenic determination factor 5; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The family is found in association with pfam00010, pfam01586. There is a conserved CSD sequence motif. Myf5 is responsible for directing cells to the skeletal myocyte lineage during development. Myf5 is likely to act in a similar way to the other MRF4 proteins such as MyoD which perform the same function. These are histone acetyltransferases and histone deacetylases which activate and repress genes involved in the myocyte lineage.


Pssm-ID: 463500  Cd Length: 71  Bit Score: 102.44  E-value: 1.21e-27
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 23111009   191 EHY---SGDSDASSPRSNCSDGMMDYSGPPSGARRRNcYEGAYYNEAPSEPRPGKSAAVSSLDCLSSIVERI 259
Cdd:pfam12232   1 ENYyglSSDSEASSPRSNCSDGMMDCNSPVWSSRNSS-FSSSYCSDLPNGSSSSKSSVVSSLDCLSSIVDRI 71
HLH smart00353
helix loop helix domain;
115-166 1.76e-15

helix loop helix domain;


Pssm-ID: 197674 [Multi-domain]  Cd Length: 53  Bit Score: 69.55  E-value: 1.76e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 23111009    115 TMRERRRLSKVNEAFETLKRCTSSNP-NQRLPKVEILRNAIRYIEGLQALLRD 166
Cdd:smart00353   1 NARERRRRRKINEAFDELRSLLPTLPkNKKLSKAEILRLAIEYIKSLQEELQK 53
HLH pfam00010
Helix-loop-helix DNA-binding domain;
110-161 2.55e-15

Helix-loop-helix DNA-binding domain;


Pssm-ID: 459628 [Multi-domain]  Cd Length: 53  Bit Score: 69.03  E-value: 2.55e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 23111009   110 RRKAATMRERRRLSKVNEAFETLKRC-TSSNPNQRLPKVEILRNAIRYIEGLQ 161
Cdd:pfam00010   1 RREAHNERERRRRDRINDAFDELRELlPTLPPDKKLSKAEILRLAIEYIKHLQ 53
 
Name Accession Description Interval E-value
BASIC smart00520
Basic domain in HLH proteins of MYOD family;
19-114 8.04e-39

Basic domain in HLH proteins of MYOD family;


Pssm-ID: 128794  Cd Length: 91  Bit Score: 132.19  E-value: 8.04e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23111009     19 SLCSFATTDDFYDDPCFDSPDLRFFEDLDPR-LMHVGALLKpeehshfpaavHPAPGAREDEHVRAPSGHHQAGRCLLWA 97
Cdd:smart00520   6 TNCYFFPSQRFYDGDCFPSPDLGFFEDLGPReLGHCGALLK-----------DELRGSEEEEHVRAPSGHHQPGQCLPWA 74
                           90
                   ....*....|....*..
gi 23111009     98 CKACKRKTTNADRRKAA 114
Cdd:smart00520  75 CKACKRKSVTMDRRKAA 91
bHLH_TS_MYOD1_Myf3 cd18936
basic helix-loop-helix (bHLH) domain found in myoblast determination protein 1 (MYOD1) and ...
105-165 4.19e-38

basic helix-loop-helix (bHLH) domain found in myoblast determination protein 1 (MYOD1) and similar proteins; MYOD1, also termed Class C basic helix-loop-helix protein 1 (bHLHc1), or myogenic factor 3 (Myf-3), is a bHLH transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with Myf-5 and MYOG, MYOD1 co-occupies muscle-specific gene promoter core region during myogenesis.


Pssm-ID: 381506  Cd Length: 61  Bit Score: 129.79  E-value: 4.19e-38
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 23111009 105 TTNADRRKAATMRERRRLSKVNEAFETLKRCTSSNPNQRLPKVEILRNAIRYIEGLQALLR 165
Cdd:cd18936   1 TTNADRRKAATMRERRRLSKVNEAFETLKRCTSTNPNQRLPKVEILRNAIRYIESLQALLR 61
bHLH_TS_MRF cd11411
basic helix-loop-helix (bHLH) domain found in myogenic regulatory factor (MRF) family; MRFs ...
109-164 1.33e-32

basic helix-loop-helix (bHLH) domain found in myogenic regulatory factor (MRF) family; MRFs are a family of muscle-specific bHLH transcription proteins (MyoD, Myf5, Mrf4 and MyoG) that plays an essential role in regulating skeletal muscle development and growth. MRFs are capable of binding to E-box motifs as a heterodimer with E-proteins to regulate transcription expression.


Pssm-ID: 381417  Cd Length: 56  Bit Score: 114.94  E-value: 1.33e-32
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 23111009 109 DRRKAATMRERRRLSKVNEAFETLKRCTSSNPNQRLPKVEILRNAIRYIEGLQALL 164
Cdd:cd11411   1 DRRKAATMRERRRLKKVNEAFEALKRCTSANPNQRLPKVEILRNAIEYIESLQDLL 56
bHLH_TS_Myf5 cd18937
basic helix-loop-helix (bHLH) domain found in myogenic factor 5 (Myf-5) and similar proteins; ...
109-167 2.76e-32

basic helix-loop-helix (bHLH) domain found in myogenic factor 5 (Myf-5) and similar proteins; Myf-5, also termed Class C basic helix-loop-helix protein 2 (bHLHc2), is a nuclear bHLH transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle specification and differentiation. It also acts as an RNA-binding protein which enhances Ccnd1/Cyclin D1 mRNA translation during myogenesis.


Pssm-ID: 381507  Cd Length: 64  Bit Score: 114.46  E-value: 2.76e-32
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 23111009 109 DRRKAATMRERRRLSKVNEAFETLKRCTSSNPNQRLPKVEILRNAIRYIEGLQALLRDQ 167
Cdd:cd18937   1 DRRKAATMRERRRLKKVNQAFETLKRCTTSNPNQRLPKVEILRNAIRYIESLQDLLREQ 59
Basic pfam01586
Myogenic Basic domain; This basic domain is found in the MyoD family of muscle specific ...
27-109 7.75e-31

Myogenic Basic domain; This basic domain is found in the MyoD family of muscle specific proteins that control muscle development. The bHLH region of the MyoD family includes the basic domain and the Helix-loop-helix (HLH) motif. The bHLH region mediates specific DNA binding. With 12 residues of the basic domain involved in DNA binding. The basic domain forms an extended alpha helix in the structure.


Pssm-ID: 460258  Cd Length: 81  Bit Score: 111.35  E-value: 7.75e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23111009    27 DDFYDDPCFDSPDLRFFEDLD-PRLMHVGALLKPEEHSHFPAAVHPAPGareDEHVRAPSGHHQAGRCLLWACKACKRKT 105
Cdd:pfam01586   1 MELYETNCYFFPDQRFYEDGEnPRLQGYDQALYQPRESPSLCGDGRAAG---EEHVRAPPGHHCPGQCLPWACKACKRKS 77

                  ....
gi 23111009   106 TNAD 109
Cdd:pfam01586  78 VTMD 81
bHLH_TS_dMYOD_like cd19699
basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster myogenic-determination ...
109-164 7.56e-30

basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster myogenic-determination protein (dMYOD) and similar proteins; dMYOD, also termed protein nautilus, or Myd, may play an important role in the early development of muscle in Drosophila.


Pssm-ID: 381542  Cd Length: 56  Bit Score: 108.01  E-value: 7.56e-30
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 23111009 109 DRRKAATMRERRRLSKVNEAFETLKRCTSSNPNQRLPKVEILRNAIRYIEGLQALL 164
Cdd:cd19699   1 DRRKAATMRERRRLRKVNEAFEVLKRRTCPNPNQRLPKVEILRNAIEYIESLEDLL 56
Myf5 pfam12232
Myogenic determination factor 5; This domain family is found in eukaryotes, and is ...
191-259 1.21e-27

Myogenic determination factor 5; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The family is found in association with pfam00010, pfam01586. There is a conserved CSD sequence motif. Myf5 is responsible for directing cells to the skeletal myocyte lineage during development. Myf5 is likely to act in a similar way to the other MRF4 proteins such as MyoD which perform the same function. These are histone acetyltransferases and histone deacetylases which activate and repress genes involved in the myocyte lineage.


Pssm-ID: 463500  Cd Length: 71  Bit Score: 102.44  E-value: 1.21e-27
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 23111009   191 EHY---SGDSDASSPRSNCSDGMMDYSGPPSGARRRNcYEGAYYNEAPSEPRPGKSAAVSSLDCLSSIVERI 259
Cdd:pfam12232   1 ENYyglSSDSEASSPRSNCSDGMMDCNSPVWSSRNSS-FSSSYCSDLPNGSSSSKSSVVSSLDCLSSIVDRI 71
bHLH_TS_MYOG_Myf4 cd18935
basic helix-loop-helix (bHLH) domain found in myogenin (MYOG) and similar proteins; MYOG, also ...
109-164 1.50e-26

basic helix-loop-helix (bHLH) domain found in myogenin (MYOG) and similar proteins; MYOG, also termed Class C basic helix-loop-helix protein 3 (bHLHc3), or myogenic factor 4 (Myf-4), is a bHLH transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation, cell cycle exit and muscle atrophy.


Pssm-ID: 381505  Cd Length: 59  Bit Score: 99.34  E-value: 1.50e-26
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 23111009 109 DRRKAATMRERRRLSKVNEAFETLKRCTSSNPNQRLPKVEILRNAIRYIEGLQALL 164
Cdd:cd18935   1 DRRRAATLREKRRLKKVNEAFEALKRSTLLNPNQRLPKVEILRSAIQYIERLQALL 56
bHLH_TS_MRF4_Myf6 cd18934
basic helix-loop-helix (bHLH) domain found in muscle-specific regulatory factor 4 (MRF4) and ...
109-168 2.06e-24

basic helix-loop-helix (bHLH) domain found in muscle-specific regulatory factor 4 (MRF4) and similar proteins; MRF4, also termed Class C basic helix-loop-helix protein 4 (bHLHc4), or myogenic factor 6 (Myf-6), is a bHLH transcription factor associated with myogenesis. It plays a role in skeletal muscle differentiation.


Pssm-ID: 381504  Cd Length: 64  Bit Score: 93.98  E-value: 2.06e-24
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 23111009 109 DRRKAATMRERRRLSKVNEAFETLKRCTSSNPNQRLPKVEILRNAIRYIEGLQALLRDQD 168
Cdd:cd18934   1 DRRKAATLRERRRLKKINEAFEALKRRTVPNPNQRLPKVEILRSAINYIEKLQDLLHSLD 60
bHLH_TS cd11390
tissue specific basic helix-loop-helix (bHLH-TS) domain family; Tissue specific bHLH domain ...
111-164 2.23e-19

tissue specific basic helix-loop-helix (bHLH-TS) domain family; Tissue specific bHLH domain family includes transcription regulators whose expression are restricted to certain tissues. They are involved in cell-fate determination and process in neurogenesis, cardiogenesis, myogenesis, and hematopoiesis and include proteins from myogenic regulatory factor (MRF) family, twist-related protein (TWIST) family, scleraxis-like family, heart- and neural crest derivatives-expressed protein (HAND) family, helix-loop-helix protein (HEN) family, musculin-like family, germline alpha (FIGLA) family, T-cell acute lymphocytic leukemia protein/ lymphoblastic leukemia-derived sequence (TAL/LYL) family, ovary, uterus and testis protein (OUT) family, mesoderm posterior protein (Mesp) family, muscle, intestine and stomach expression 1 (MIST-1) family, protein atonal homologs (ATOH) family, neurogenin (NGN) family, neurogenic differentiation factor (NeuroD) family, achaete-scute complex-like (ASCL) family, Fer3-like protein (FERD3L)-like family, and Oligodendrocyte lineage genes (OLIG) family of transcription factors.


Pssm-ID: 381396 [Multi-domain]  Cd Length: 55  Bit Score: 79.92  E-value: 2.23e-19
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 23111009 111 RKAATMRERRRLSKVNEAFETLKRCTSS-NPNQRLPKVEILRNAIRYIEGLQALL 164
Cdd:cd11390   1 RNAANARERRRMHDLNDAFEALRKVLPTvPPDKKLSKIETLRLAINYIAALSDLL 55
HLH smart00353
helix loop helix domain;
115-166 1.76e-15

helix loop helix domain;


Pssm-ID: 197674 [Multi-domain]  Cd Length: 53  Bit Score: 69.55  E-value: 1.76e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 23111009    115 TMRERRRLSKVNEAFETLKRCTSSNP-NQRLPKVEILRNAIRYIEGLQALLRD 166
Cdd:smart00353   1 NARERRRRRKINEAFDELRSLLPTLPkNKKLSKAEILRLAIEYIKSLQEELQK 53
HLH pfam00010
Helix-loop-helix DNA-binding domain;
110-161 2.55e-15

Helix-loop-helix DNA-binding domain;


Pssm-ID: 459628 [Multi-domain]  Cd Length: 53  Bit Score: 69.03  E-value: 2.55e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 23111009   110 RRKAATMRERRRLSKVNEAFETLKRC-TSSNPNQRLPKVEILRNAIRYIEGLQ 161
Cdd:pfam00010   1 RREAHNERERRRRDRINDAFDELRELlPTLPPDKKLSKAEILRLAIEYIKHLQ 53
bHLH_TS_FERD3L_like cd19686
basic helix-loop-helix (bHLH) domain found in Fer3-like protein (FERD3L), pancreas ...
111-164 1.43e-13

basic helix-loop-helix (bHLH) domain found in Fer3-like protein (FERD3L), pancreas transcription factor 1 subunit alpha (PTF1A) and similar proteins; The family corresponds to a group of bHLH transcription factors, including FERD3L and PTF1A. FERD3L, also termed basic helix-loop-helix protein N-twist, or Class A basic helix-loop-helix protein 31 (bHLHa31), or nephew of atonal 3 (NATO3), or Neuronal twist (NTWIST), is expressed in the developing central nervous system (CNS). It regulates floor plate (FP) cells development. FP is a critical organizing center located at the ventral-most midline of the neural tube. FERD3L binds to the E-box and functions as inhibitor of transcription. PTF1A, also termed Class A basic helix-loop-helix protein 29 (bHLHa29), or pancreas-specific transcription factor 1a, or bHLH transcription factor p48, or p48 DNA-binding subunit of transcription factor PTF1 (PTF1-p48), is implicated in the cell fate determination in various organs. It binds to the E-box consensus sequence 5'-CANNTG-3' and plays a role in early and late pancreas development and differentiation.


Pssm-ID: 381529 [Multi-domain]  Cd Length: 56  Bit Score: 64.37  E-value: 1.43e-13
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 23111009 111 RKAATMRERRRLSKVNEAFETLKRCTSSNP-NQRLPKVEILRNAIRYIEGLQALL 164
Cdd:cd19686   2 RQAANIRERKRMRSINDAFDGLRRHIPTFPyEKRLSKVDTLRLAIQYINFLTELL 56
bHLH_TS_ASCL cd11418
basic helix-loop-helix (bHLH) domain found in achaete-scute complex-like (ASCL) family; The ...
110-164 8.75e-13

basic helix-loop-helix (bHLH) domain found in achaete-scute complex-like (ASCL) family; The achaete-scute complex-like (ASCL, also known as achaete-scute complex homolog or ASH) family of bHLH transcription factors, ASCL1-5, have been implicated in cell fate specification and differentiation. They are critical for proper development of the nervous system. The deregulation of ASCL plays a key role in psychiatric and neurological disorders. ASCL-1, also termed Class A basic helix-loop-helix protein 46 (bHLHa46), or achaete-scute homolog 1 (ASH-1), or mammalian achaete-scute homolog 1 (Mash1), is a neural-specific bHLH transcription factor that is expressed in subsets of neural progenitors in both the central and peripheral nervous system. It plays a key role in neuronal differentiation and specification in the nervous system. ASCL-2, also termed achaete-scute homolog 2 (ASH-2), or Class A basic helix-loop-helix protein 45 (bHLHa45), or mammalian achaete-scute homolog 2 (Mash2), is a bHLH transcription factor that is involved in Schwann cell differentiation and control of proliferation in adult peripheral nerves. ASCL-3, also termed Class A basic helix-loop-helix protein 42 (bHLHa42), or bHLH transcriptional regulator Sgn-1, or achaete-scute homolog 3 (ASH-3), is a bHLH transcription factor specifically localized in the duct cells of the salivary glands. It may act as transcriptional repressor that inhibits myogenesis. The family also includes Drosophila melanogaster achaete-scute complex (AS-C) proteins, which consists of lethal of scute (also known as achaete-scute complex protein T3 or AST3), scute (also known as achaete-scute complex protein T4 or AST4), achaete (also known as achaete-scute complex protein T5 or AST5), and asense (also known as achaete-scute complex protein T8 or AST8). They are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system, as well as in sex determination and dosage compensation.


Pssm-ID: 381424 [Multi-domain]  Cd Length: 56  Bit Score: 62.24  E-value: 8.75e-13
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 23111009 110 RRKAatmRERRRLSKVNEAFETLKRCTSS-NPNQRLPKVEILRNAIRYIEGLQALL 164
Cdd:cd11418   4 RRNE---RERRRVQAVNDAFDRLRQHVPYlKRRKKLSKVKTLRRAIEYIRHLQKLL 56
bHLH_TS_taxi_Dei cd11431
basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster protein taxi and similar ...
110-164 1.15e-11

basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster protein taxi and similar proteins; Protein taxi, also termed protein delilah (Dei), is a bHLH transcription factor that is involved in regulation of cell adhesion and attachment that is expressed in specialized cells that provide anchoring sites to either muscles (tendon cells), or proprioceptors (chordotonal attachment cells) during embryonic development. It probably plays an important role in the differentiation of epidermal cells into the tendon cells that form the attachment sites for all muscles.


Pssm-ID: 381437 [Multi-domain]  Cd Length: 59  Bit Score: 58.98  E-value: 1.15e-11
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 23111009 110 RRKAATMRERRRLSKVNEAFETLKRCTSSNP----NQRLPKVEILRNAIRYIEGLQALL 164
Cdd:cd11431   1 RRKTANARERDRMREINDAFEALRRAVPEYPvagkDGKLTKITTLRLAMNYIKALTDLL 59
bHLH_TS_ASCL3_like cd19724
basic helix-loop-helix (bHLH) domain found in achaete-scute-like proteins, ASCL3-5, and ...
117-164 3.09e-11

basic helix-loop-helix (bHLH) domain found in achaete-scute-like proteins, ASCL3-5, and similar proteins; This subfamily includes three ASCL family of transcription factors, ASCL-3, ASCL-4 and ASCL-5. ASCL-3, also termed Class A basic helix-loop-helix protein 42 (bHLHa42), or bHLH transcriptional regulator Sgn-1, or achaete-scute homolog 3 (ASH-3), is specifically localized in the duct cells of the salivary glands. It may act as transcriptional repressor that inhibits myogenesis. ASCL-4, also termed Class A basic helix-loop-helix protein 44 (bHLHa44), or achaete-scute homolog 4 (ASH-4), or Hash4, may be involved in skin development. ASCL-5, also termed Class A basic helix-loop-helix protein 47 (bHLHa47), or achaete-scute homolog 5 (ASH-5), is an uncharacterized bHLH transcription factor that is close related to ASCL-3 and ASCL-4.


Pssm-ID: 381567  Cd Length: 56  Bit Score: 57.70  E-value: 3.09e-11
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 23111009 117 RERRRLSKVNEAFETLKRCTS-SNPNQRLPKVEILRNAIRYIEGLQALL 164
Cdd:cd19724   8 RERQRVRCVNEGYARLRRHLPlENKDKRLSKVETLRAAIRYIKHLQELL 56
bHLH_SF cd00083
basic Helix Loop Helix (bHLH) domain superfamily; bHLH proteins are transcriptional regulators ...
118-162 8.04e-11

basic Helix Loop Helix (bHLH) domain superfamily; bHLH proteins are transcriptional regulators that are found in organisms from yeast to humans. Members of the bHLH superfamily have two highly conserved and functionally distinct regions. The basic part is at the amino end of the bHLH that may bind DNA to a consensus hexanucleotide sequence known as the E box (CANNTG). Different families of bHLH proteins recognize different E-box consensus sequences. At the carboxyl-terminal end of the region is the HLH region that interacts with other proteins to form homo- and heterodimers. bHLH proteins function as a diverse set of regulatory factors because they recognize different DNA sequences and dimerize with different proteins. The bHLH proteins can be divided to cell-type specific and widely expressed proteins. The cell-type specific members of bHLH superfamily are involved in cell-fate determination and act in neurogenesis, cardiogenesis, myogenesis, and hematopoiesis.


Pssm-ID: 381392 [Multi-domain]  Cd Length: 46  Bit Score: 56.37  E-value: 8.04e-11
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 23111009 118 ERRRLSKVNEAFETLKRCTSSNPN-QRLPKVEILRNAIRYIEGLQA 162
Cdd:cd00083   1 ERRRRDKINDAFEELKRLLPELPDsKKLSKASILQKAVEYIRELQS 46
bHLH_TS_PTF1A cd11417
basic helix-loop-helix (bHLH) domain found in pancreas transcription factor 1 subunit alpha ...
110-164 7.20e-10

basic helix-loop-helix (bHLH) domain found in pancreas transcription factor 1 subunit alpha (PTF1A) and similar proteins; PTF1A, also termed Class A basic helix-loop-helix protein 29 (bHLHa29), or pancreas-specific transcription factor 1a, or bHLH transcription factor p48, or p48 DNA-binding subunit of transcription factor PTF1 (PTF1-p48), is a bHLH transcription factor implicated in the cell fate determination in various organs. It binds to the E-box consensus sequence 5'-CANNTG-3' and plays a role in early and late pancreas development and differentiation.


Pssm-ID: 381423 [Multi-domain]  Cd Length: 56  Bit Score: 54.08  E-value: 7.20e-10
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 23111009 110 RRKAATMRERRRLSKVNEAFETLKRCTSSNP-NQRLPKVEILRNAIRYIEGLQALL 164
Cdd:cd11417   1 QRQAANLRERRRMQSINDAFEGLRSHIPTLPyEKRLSKVDTLRLAIGYINFLSELV 56
bHLH_TS_FERD3L_NATO3 cd11415
basic helix-loop-helix (bHLH) domain found in Fer3-like protein (FERD3L) and similar proteins; ...
102-164 9.04e-10

basic helix-loop-helix (bHLH) domain found in Fer3-like protein (FERD3L) and similar proteins; FERD3L, also termed basic helix-loop-helix protein N-twist, or Class A basic helix-loop-helix protein 31 (bHLHa31), or nephew of atonal 3 (NATO3), or Neuronal twist (NTWIST), is a bHLH transcription factor expressed in the developing central nervous system (CNS). It regulates floor plate (FP) cells development. FP is a critical organizing center located at the ventral-most midline of the neural tube. FERD3L binds to the E-box and functions as inhibitor of transcription.


Pssm-ID: 381421 [Multi-domain]  Cd Length: 64  Bit Score: 53.97  E-value: 9.04e-10
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 23111009 102 KRKTTNAdRRKAATMRERRRLSKVNEAFETLKRCTSSNP-NQRLPKVEILRNAIRYIEGLQALL 164
Cdd:cd11415   2 KRVITYA-QRQAANIRERRRMFNLNEAFDKLRKKVPTFAyEKRLSRIETLRLAIVYISFMTDLL 64
bHLH_TS_TAL_LYL cd11413
basic helix-loop-helix (bHLH) domain found in T-cell acute lymphocytic leukemia protein/ ...
110-168 1.08e-09

basic helix-loop-helix (bHLH) domain found in T-cell acute lymphocytic leukemia protein/ lymphoblastic leukemia-derived sequence (TAL/LYL) family; The TAL/LYL family includes a group of bHLH transcription factors (TAL1, TAL2 and LYL1) implicated in T cell acute leukaemia. They act as mediators of T cell leukaemogenesis. TAL-1, also termed Class A basic helix-loop-helix protein 17 (bHLHa17), or stem cell protein (SCL), or T-cell leukemia/lymphoma protein 5, is a hematopoietic-specific bHLH transcription factor that functions in embryonic and adult hematopoiesis in vertebrates. It is also required for embryonic vascular remodeling. It acts as a regulator of erythroid differentiation and binds to regulatory regions of a large cohort of erythroid genes as part of a complex with GATA-1, LMO2 and Ldb1. TAL-2, also termed Class A basic helix-loop-helix protein 19 (bHLHa19), is a bHLH transcription factor essential for the normal brain development. Lyl-1, also termed Class A basic helix-loop-helix protein 18 (bHLHa18), or lymphoblastic leukemia-derived sequence 1, is a proto-oncogenic bHLH transcription factor that plays an important role in hematopoietic stem cell function and is required for the late stages of postnatal angiogenesis to limit the formation of new blood vessels, notably by regulating the activity of the small GTPase Rap1. LYL-1 deficiency induces a stress erythropoiesis.


Pssm-ID: 381419 [Multi-domain]  Cd Length: 60  Bit Score: 53.61  E-value: 1.08e-09
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 23111009 110 RRKAATMRERRRLSKVNEAFETLKRCTSSNP-NQRLPKVEILRNAIRYIEGLQALLRDQD 168
Cdd:cd11413   1 RRIFTNTRERWRQQNVNGAFAELRKLIPTHPpDKKLSKNEILRLAMKYIKFLEKILEDQE 60
bHLH_TS_ASCL1_like cd19723
basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster achaete-scute complex ...
110-164 3.20e-09

basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster achaete-scute complex (AS-C) proteins, achaete-scute-like proteins, ASCL1-2, and similar proteins; This subfamily includes Drosophila melanogaster AS-C proteins and two ASCL family of transcription factors, ASCL-1 and ASCL-2. Drosophila melanogaster AS-C proteins includes lethal of scute (also known as achaete-scute complex protein T3 or AST3), scute (also known as achaete-scute complex protein T4 or AST4), achaete (also known as achaete-scute complex protein T5 or AST5), and asense (also known as achaete-scute complex protein T8 or AST8). They are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system, as well as in sex determination and dosage compensation. ASCL-1, also termed Class A basic helix-loop-helix protein 46 (bHLHa46), or achaete-scute homolog 1 (ASH-1), or mammalian achaete scute homolog 1 (Mash1), is expressed in subsets of neural progenitors in both the central and peripheral nervous system. It plays a key role in neuronal differentiation and specification in the nervous system. ASCL-2, also termed achaete-scute homolog 2 (ASH-2), or Class A basic helix-loop-helix protein 45 (bHLHa45), or mammalian achaete scute homolog 2 (Mash2), is involved in Schwann cell differentiation and control of proliferation in adult peripheral nerves.


Pssm-ID: 381566  Cd Length: 56  Bit Score: 52.06  E-value: 3.20e-09
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 23111009 110 RRKAatmRERRRLSKVNEAFETLKRCTSSNP-NQRLPKVEILRNAIRYIEGLQALL 164
Cdd:cd19723   4 RRNE---RERNRVKLVNLGFATLREHVPNGRaNKKMSKVETLRSAVEYIRQLQQLL 56
bHLH_TS_FIGLA cd11422
basic helix-loop-helix (bHLH) domain found in factor in the germline alpha (FIGLA) and similar ...
111-165 7.97e-09

basic helix-loop-helix (bHLH) domain found in factor in the germline alpha (FIGLA) and similar proteins; FIGLA, also termed FIGalpha, or Class C basic helix-loop-helix protein 8 (bHLHc8), or folliculogenesis-specific basic helix-loop-helix protein, or transcription factor FIGa, is a germ-cell-specific bHLH transcription factor expressed abundantly in female and less so in male germ cells. It is essential for primordial follicle formation and expression of many genes required for folliculogenesis, fertilization and early embryonic survival. FIGLA knockout mice cannot form primordial follicles and lose oocytes rapidly after birth, whereas male gonads are unaffected.


Pssm-ID: 381428  Cd Length: 56  Bit Score: 51.20  E-value: 7.97e-09
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 23111009 111 RKAATMRERRRLSKVNEAFETLKRCTSSNPNQRLP-KVEILRNAIRYIEGLQALLR 165
Cdd:cd11422   1 RRVANARERERVRNLNSGFSKLRRIVPLIPRDRKPsKVDTLKGATEYIRLLQRILE 56
bHLH_TS_ATOH8 cd11421
basic helix-loop-helix (bHLH) domain found in protein atonal homolog 8 (ATOH8) and similar ...
104-168 9.70e-09

basic helix-loop-helix (bHLH) domain found in protein atonal homolog 8 (ATOH8) and similar proteins; ATOH8, also termed Class A basic helix-loop-helix protein 21 (bHLHa21), or helix-loop-helix protein hATH-6 (hATH6), is a bHLH shear-stress-responsive transcription factor expressed in activated satellite cells and proliferating myoblasts of human skeletal muscle tissue. It regulates endothelial cell proliferation, migration and tube-like structures formation. ATOH8 binds a palindromic (canonical) core consensus DNA sequence 5'-CANNTG- 3' known as an E-box element, possibly as a heterodimer with other bHLH proteins.


Pssm-ID: 381427 [Multi-domain]  Cd Length: 68  Bit Score: 51.28  E-value: 9.70e-09
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 23111009 104 KTTNADRRKAATMRERRRLSKVNEAFETLKRCTSS-NPNQRLPKVEILRNAIRYIEGLQALLrDQD 168
Cdd:cd11421   2 KNMTRQRRIEANARERTRVHTISAAFEALRKAVPSySYNQKLSKLAILRIACSYILALARLA-DLD 66
bHLH_TS_scleraxis_like cd11465
basic helix-loop-helix (bHLH) domain found in scleraxis, transcription factor 15 (TCF-15) and ...
111-164 3.20e-08

basic helix-loop-helix (bHLH) domain found in scleraxis, transcription factor 15 (TCF-15) and similar proteins; The family includes scleraxis and transcription factor 15 (TCF-15). Scleraxis, also termed SCX, or Class A basic helix-loop-helix protein 41 (bHLHa41), or Class A basic helix-loop-helix protein 48 (bHLHa48), is a bHLH transcription factor that is expressed in sclerotome limb bud cranial and body wall mesenchyme, pericardium and heart valves, ligaments and tendons. It is required for tendon formation ligaments, connective tissue, the diaphragm, and testis development. Scleraxis plays a central role in promoting fibroblast proliferation and matrix synthesis during the embryonic development of tendons. TCF-15, also termed Class A basic helix-loop-helix protein 40 (bHLHa40), or paraxis, or protein bHLH-EC2, is a bHLH transcription factor expressed in caudal lateral and paraxial mesoderm dermomyotome and sclerotome fore limb buds during embryo development. It may function as an early transcriptional regulator involved in the patterning of the mesoderm and in lineage determination of cell types derived from the mesoderm.


Pssm-ID: 381471 [Multi-domain]  Cd Length: 55  Bit Score: 49.34  E-value: 3.20e-08
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 23111009 111 RKAATMRERRRLSKVNEAFETLKRCTSSNP-NQRLPKVEILRNAIRYIEGLQALL 164
Cdd:cd11465   1 RQAANARERDRTHSVNSAFTALRTLIPTEPaDRKLSKIETLRLASSYISHLATVL 55
bHLH_TS_ATOH1_like cd11430
basic helix-loop-helix (bHLH) domain found in protein atonal homologs ATOH1, ATOH7 and similar ...
110-164 3.86e-08

basic helix-loop-helix (bHLH) domain found in protein atonal homologs ATOH1, ATOH7 and similar proteins; The family includes ATOH1 and ATOH7. ATOH1, also termed Class A basic helix-loop-helix protein 14 (bHLHa14), or helix-loop-helix protein hATH-1 (hATH1), or Math1, or Cath1, is a proneural bHLH transcription factor that is essential for inner ear hair cell differentiation. It dimerizes with E47 and activates E-box (CANNTG) dependent transcription. ATOH1 is a mammalian homolog of the Drosophila melanogaster gene atonal and mouse atonal homolog 1 (Math1). ATOH7, also termed Class A basic helix-loop-helix protein 13 (bHLHa13), or helix-loop-helix protein hATH-5 (hATH5), or Math5, is a bHLH transcription factor involved in the differentiation of retinal ganglion cells. The family also includes protein Amos (also termed absent MD neurons and olfactory sensilla protein, or reduced olfactory organs protein, or rough eye protein). It is a bHLH transcription factor that promotes multiple dendritic neuron formation in the Drosophila peripheral nervous system.


Pssm-ID: 381436 [Multi-domain]  Cd Length: 56  Bit Score: 49.36  E-value: 3.86e-08
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 23111009 110 RRKAATMRERRRLSKVNEAFETLKRCT-SSNPNQRLPKVEILRNAIRYIEGLQALL 164
Cdd:cd11430   1 RRLAANARERRRMNGLNRAFDQLRSVVpSIGNDKKLSKYETLQMAQIYIETLSELL 56
bHLH_TS_LYL1 cd19705
basic helix-loop-helix (bHLH) domain found in protein lyl-1 and similar proteins; Lyl-1, also ...
110-167 5.66e-08

basic helix-loop-helix (bHLH) domain found in protein lyl-1 and similar proteins; Lyl-1, also termed Class A basic helix-loop-helix protein 18 (bHLHa18), or lymphoblastic leukemia-derived sequence 1, is a proto-oncogenic bHLH transcription factor involved in T-cell acute lymphoblastic leukemia. It plays an important role in hematopoietic stem cell function and is required for the late stages of postnatal angiogenesis to limit the formation of new blood vessels, notably by regulating the activity of the small GTPase Rap1. LYL-1 deficiency induces a stress erythropoiesis.


Pssm-ID: 381548 [Multi-domain]  Cd Length: 65  Bit Score: 48.86  E-value: 5.66e-08
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 23111009 110 RRKAATMRERRRLSKVNEAFETLKRCTSSNP-NQRLPKVEILRNAIRYIEGLQALLRDQ 167
Cdd:cd19705   6 RRVFTNSRERWRQQNVNGAFAELRKLIPTHPpDKKLSKNEILRLAMKYIDFLVTLLRDQ 64
bHLH_TS_TAL2 cd19707
basic helix-loop-helix (bHLH) domain found in T-cell acute lymphocytic leukemia protein 2 ...
110-168 5.88e-08

basic helix-loop-helix (bHLH) domain found in T-cell acute lymphocytic leukemia protein 2 (TAL-2) and similar proteins; TAL-2, also termed Class A basic helix-loop-helix protein 19 (bHLHa19), is a bHLH transcription factor essential for the normal brain development. It has been implicated in T-cell acute lymphoblastic leukemia.


Pssm-ID: 381550 [Multi-domain]  Cd Length: 61  Bit Score: 48.83  E-value: 5.88e-08
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 23111009 110 RRKAATMRERRRLSKVNEAFETLKRCTSSNP-NQRLPKVEILRNAIRYIEGLQALLRDQD 168
Cdd:cd19707   2 RKIFTNTRERWRQQNVNSAFAELRKLIPTHPpDKKLSKNEILRLAMKYINFLVKLLGDQG 61
bHLH_TS_ATOH7 cd19714
basic helix-loop-helix (bHLH) domain found in protein atonal homolog 7 (ATOH7) and similar ...
110-166 9.41e-08

basic helix-loop-helix (bHLH) domain found in protein atonal homolog 7 (ATOH7) and similar proteins; ATOH7, also termed Class A basic helix-loop-helix protein 13 (bHLHa13), or helix-loop-helix protein hATH-5 (hATH5), or Math5, is a bHLH transcription factor involved in the differentiation of retinal ganglion cells.


Pssm-ID: 381557 [Multi-domain]  Cd Length: 69  Bit Score: 48.41  E-value: 9.41e-08
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 23111009 110 RRKAATMRERRRLSKVNEAFETLKRCTSS-NPNQRLPKVEILRNAIRYIEGLQALLRD 166
Cdd:cd19714   8 RRLAANARERRRMQGLNTAFDRLRKVVPQwGQDKKLSKYETLQMALSYIMALTRILAE 65
bHLH_TS_TWIST cd11464
basic helix-loop-helix (bHLH) domain found in twist-related protein (TWIST) family; The TWIST ...
110-168 1.09e-07

basic helix-loop-helix (bHLH) domain found in twist-related protein (TWIST) family; The TWIST family includes TWIST1 and TWIST2, which are highly homologous bHLH transcription factors that promote epithelial-mesenchymal transition (EMT) during development and tumor metastasis. They are involved in the negative regulation of cellular determination and in the differentiation of several lineages, including myogenesis, osteogenesis, and neurogenesis. TWIST factors express in broad partially-overlapping patterns during embryo development and dimerize with a broad sets of dimer partners that form numerous unique transcriptional complexes to regulate embryonic development.


Pssm-ID: 381470 [Multi-domain]  Cd Length: 59  Bit Score: 47.87  E-value: 1.09e-07
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 23111009 110 RRKAATMRERRRLSKVNEAFETLKRCTSSNPNQRLPKVEILRNAIRYIEGLQALLRDQD 168
Cdd:cd11464   1 QRVLANVRERQRTQSLNEAFTSLRKIIPTLPSDKLSKIQTLKLAARYIDFLYQVLRSDE 59
bHLH_TS_dHLH3B_like cd19708
basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster helix loop helix protein ...
110-167 1.20e-07

basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster helix loop helix protein 3B (dHLH3B) and similar proteins; Drosophila HLH3B is an uncharacterized bHLH transcription factor that belongs to the T-cell acute lymphocytic leukemia protein/ lymphoblastic leukemia-derived sequence (TAL/LYL) family.


Pssm-ID: 381551 [Multi-domain]  Cd Length: 60  Bit Score: 47.96  E-value: 1.20e-07
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 23111009 110 RRKAATMRERRRLSKVNEAFETLKRCTSSNP-NQRLPKVEILRNAIRYIEGLQALLRDQ 167
Cdd:cd19708   1 RRMFTNSRERWRQQNVNGAFAELRKLVPTHPpDKKLSKNEILRLAIKYIRLLSNVLEWQ 59
bHLH_TS_TWIST1 cd11412
basic helix-loop-helix (bHLH) domain found in twist-related protein 1 (TWIST1) and similar ...
109-167 1.41e-07

basic helix-loop-helix (bHLH) domain found in twist-related protein 1 (TWIST1) and similar proteins; TWIST1, also termed Class A basic helix-loop-helix protein 38 (bHLHa38), or H-twist, is a bHLH transcriptional regulator that inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. It also represses expression of proinflammatory cytokines such as TNFA and IL1B. In addition, TWIST1 is involved in cancer development and progression.


Pssm-ID: 381418 [Multi-domain]  Cd Length: 77  Bit Score: 48.24  E-value: 1.41e-07
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 23111009 109 DRRKAATMRERRRLSKVNEAFETLKRCTSSNPNQRLPKVEILRNAIRYIEGL-QALLRDQ 167
Cdd:cd11412  11 TQRVMANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFLyQVLQSDE 70
bHLH_TS_ASCL1_Mash1 cd19742
basic helix-loop-helix (bHLH) domain found in achaete-scute-like protein 1 (ASCL-1) and ...
117-168 1.66e-07

basic helix-loop-helix (bHLH) domain found in achaete-scute-like protein 1 (ASCL-1) and similar proteins; ASCL-1, also termed Class A basic helix-loop-helix protein 46 (bHLHa46), or achaete-scute homolog 1 (ASH-1), or mammalian achaete scute homolog 1 (Mash1), is a neural-specific bHLH transcription factor that is expressed in subsets of neural progenitors in both the central and peripheral nervous system. It plays a key role in neuronal differentiation and specification in the nervous system.


Pssm-ID: 381585  Cd Length: 71  Bit Score: 47.83  E-value: 1.66e-07
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 23111009 117 RERRRLSKVNEAFETLKR-CTSSNPNQRLPKVEILRNAIRYIEGLQALLRDQD 168
Cdd:cd19742  12 RERNRVKLVNMGFATLREhVPNGAANKKMSKVETLRSAVEYIRALQQLLDEHD 64
bHLH_TS_ASCL2_Mash2 cd19743
basic helix-loop-helix (bHLH) domain found in achaete-scute-like protein 2 (ASCL-2) and ...
105-168 2.01e-07

basic helix-loop-helix (bHLH) domain found in achaete-scute-like protein 2 (ASCL-2) and similar proteins; ASCL-2, also termed achaete-scute homolog 2 (ASH-2), or Class A basic helix-loop-helix protein 45 (bHLHa45), or mammalian achaete scute homolog 2 (Mash2), is a bHLH transcription factor that is involved in Schwann cell differentiation and control of proliferation in adult peripheral nerves.


Pssm-ID: 381586  Cd Length: 64  Bit Score: 47.27  E-value: 2.01e-07
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 23111009 105 TTNADRRKAatmRERRRLSKVNEAFETLKR-CTSSNPNQRLPKVEILRNAIRYIEGLQALLRDQD 168
Cdd:cd19743   1 AAAVERRNE---RERNRVKLVNLGFAALRQhVPQGGASKKMSKVETLRSAVEYIRALQRLLGEHD 62
bHLH_TS_TAL1 cd19706
basic helix-loop-helix (bHLH) domain found in T-cell acute lymphocytic leukemia protein 1 ...
110-168 3.43e-07

basic helix-loop-helix (bHLH) domain found in T-cell acute lymphocytic leukemia protein 1 (TAL-1) and similar proteins; TAL-1, also termed Class A basic helix-loop-helix protein 17 (bHLHa17), or stem cell protein (SCL), or T-cell leukemia/lymphoma protein 5, is a hematopoietic-specific bHLH transcription factor that functions in embryonic and adult hematopoiesis in vertebrates. It is also required for embryonic vascular remodeling. It acts as a regulator of erythroid differentiation and binds to regulatory regions of a large cohort of erythroid genes as part of a complex with GATA-1, LMO2 and Ldb1. TAL-1 has been implicated in T-cell acute lymphoblastic leukemia. In common with other tissue-specific bHLH proteins, Tal heterodimerizes with ubiquitously-expressed members of the E2A family and form a DNA-binding complex with an E-box (CANNTG) to regulate transcription at its recognition site.


Pssm-ID: 381549 [Multi-domain]  Cd Length: 65  Bit Score: 46.96  E-value: 3.43e-07
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 23111009 110 RRKAATMRERRRLSKVNEAFETLKRCTSSNP-NQRLPKVEILRNAIRYIEGLQALLRDQD 168
Cdd:cd19706   4 RRIFTNSRERWRQQNVNGAFAELRKLIPTHPpDKKLSKNEILRLAMKYINFLAKLLNDQE 63
bHLH_TS_ASCL3 cd19745
basic helix-loop-helix (bHLH) domain found in achaete-scute-like protein 3 (ASCL-3) and ...
117-164 3.56e-07

basic helix-loop-helix (bHLH) domain found in achaete-scute-like protein 3 (ASCL-3) and similar proteins; ASCL-3, also termed Class A basic helix-loop-helix protein 42 (bHLHa42), or bHLH transcriptional regulator Sgn-1, or achaete-scute homolog 3 (ASH-3), is a bHLH transcription factor specifically localized in the duct cells of the salivary glands. It may act as transcriptional repressor that inhibits myogenesis.


Pssm-ID: 381588  Cd Length: 59  Bit Score: 46.39  E-value: 3.56e-07
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 23111009 117 RERRRLSKVNEAFETLKR-CTSSNPNQRLPKVEILRNAIRYIEGLQALL 164
Cdd:cd19745  11 RERQRVKCVNEGYAKLRRhLPQEYSEKRLSKVETLRAAIKYIKHLQSVL 59
bHLH_TS_NeuroD6_ATOH2 cd19722
basic helix-loop-helix (bHLH) domain found in neurogenic differentiation factor 6 (NeuroD6) ...
110-165 4.25e-07

basic helix-loop-helix (bHLH) domain found in neurogenic differentiation factor 6 (NeuroD6) and similar proteins; NeuroD6, also termed Class A basic helix-loop-helix protein 2 (bHLHa2), or protein atonal homolog 2 (ATH-2), or Atoh2, or Math2, or Nex1, is a neurogenic bHLH transcription factor involved in neuronal development, differentiation, and survival in Alzheimer's disease (AD) brains of both cohorts. It plays an integrative role in coordinating increase in mitochondrial mass with cytoskeletal remodeling, suggesting that it may act as a co-regulator of neuronal differentiation and energy metabolism.


Pssm-ID: 381565 [Multi-domain]  Cd Length: 70  Bit Score: 46.56  E-value: 4.25e-07
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 23111009 110 RRKAATMRERRRLSKVNEAFETLKR---CTSSnpNQRLPKVEILRNAIRYIEGLQALLR 165
Cdd:cd19722  14 RRQEANARERNRMHGLNDALDSLRKvvpCYSK--TQKLSKIETLRLAKNYIWALSEILR 70
bHLH_TS_ceHLH13_like cd11416
basic helix-loop-helix (bHLH) domain found in Caenorhabditis elegans Helix-loop-helix protein ...
110-166 4.98e-07

basic helix-loop-helix (bHLH) domain found in Caenorhabditis elegans Helix-loop-helix protein 13 (HLH13) and similar proteins; Caenorhabditis elegans HLH13, also termed Fer3-like protein, or nephew of atonal 3, is a bHLH transcription factor that plays a role in the negative regulation of exit from L1 arrest and dauer diapause dependent on IIS signaling (insulin and insulin-like growth factor (IGF) signaling).


Pssm-ID: 381422 [Multi-domain]  Cd Length: 63  Bit Score: 46.35  E-value: 4.98e-07
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 23111009 110 RRKAATMRERRRLSKVNEAFETLKRCTSSNP-NQRLPKVEILRNAIRYIeglqALLRD 166
Cdd:cd11416   5 QRHAANIRERKRMLSINSAFEELRCHVPTFPyEKRLSKIDTLRLAIAYI----ALLRD 58
bHLH_TS_ASCL5 cd19747
basic helix-loop-helix (bHLH) domain found in achaete-scute-like protein 5 (ASCL-5) and ...
117-164 6.80e-07

basic helix-loop-helix (bHLH) domain found in achaete-scute-like protein 5 (ASCL-5) and similar proteins; ASCL-5, also termed Class A basic helix-loop-helix protein 47 (bHLHa47), or achaete-scute homolog 5 (ASH-5), is an uncharacterized bHLH transcription factor that belongs to AS-C (achaete, scute, lethal of scute, and asense) family.


Pssm-ID: 381590  Cd Length: 61  Bit Score: 45.76  E-value: 6.80e-07
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 23111009 117 RERRRLSKVNEAFETLK-RCTSSNPNQRLPKVEILRNAIRYIEGLQALL 164
Cdd:cd19747  13 RERQRVKCVNEGYARLRdHLPGAMAEKRLSKVETLRAAIRYIKYLQDLL 61
bHLH_TS_bHLHa9 cd18912
basic helix-loop-helix (bHLH) domain found in Class A basic helix-loop-helix protein 9 (bHLHa9) ...
110-164 2.15e-06

basic helix-loop-helix (bHLH) domain found in Class A basic helix-loop-helix protein 9 (bHLHa9) and similar proteins; bHLHa9, also termed Class F basic helix-loop-helix factor 42 (bHLHf42), is a bHLH transcription factor that plays an essential role in limb development.


Pssm-ID: 381482  Cd Length: 63  Bit Score: 44.55  E-value: 2.15e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 23111009 110 RRKAATMRERRRLSKVNEAFETLKRCTSSNPN-QRLPKVEILRNAIRYIEGLQALL 164
Cdd:cd18912   8 RRVAANVRERKRILDYNQAFNALRLALKHDLGgKRLSKIATLRRAINRISALSLFL 63
bHLH_TS_ATOH1 cd19713
basic helix-loop-helix (bHLH) domain found in protein atonal homolog 1 (ATOH1) and similar ...
110-164 2.80e-06

basic helix-loop-helix (bHLH) domain found in protein atonal homolog 1 (ATOH1) and similar proteins; ATOH1, also termed Class A basic helix-loop-helix protein 14 (bHLHa14), or helix-loop-helix protein hATH-1 (hATH1), or Math1, or Cath1, is a proneural bHLH transcription factor that is essential for inner ear hair cell differentiation. It dimerizes with E47 and activates E-box (CANNTG) dependent transcription. ATOH1 is a mammalian homolog of the Drosophila melanogaster gene atonal and mouse atonal homolog 1 (Math1).


Pssm-ID: 381556  Cd Length: 64  Bit Score: 44.17  E-value: 2.80e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 23111009 110 RRKAATMRERRRLSKVNEAFETLKRCTSS-NPNQRLPKVEILRNAIRYIEGLQALL 164
Cdd:cd19713   6 RRLAANARERRRMHGLNHAFDQLRNVIPSfNNDKKLSKYETLQMAQIYINALSELL 61
bHLH_TS_NGN cd11428
basic helix-loop-helix (bHLH) domain found in neurogenin (NGN) family; The NGN family includes ...
110-165 2.89e-06

basic helix-loop-helix (bHLH) domain found in neurogenin (NGN) family; The NGN family includes three neural-specific bHLH transcription factors, NGN1-3, which may function at neuroblast selection genes during the development of several neuronal lineages. NGN-1, also termed Class A basic helix-loop-helix protein 6 (bHLHa6), or neurogenic basic-helix-loop-helix protein, or neurogenic differentiation factor 3 (NeuroD3), is a neural-specific bHLH transcription factor involved in the initiation of neuronal differentiation. NGN-2, also termed Class A basic helix-loop-helix protein 8 (bHLHa8), or protein atonal homolog 4 (ATOH4), is a neural-specific bHLH transcription factor required for sensory neurogenesis. NGN-3, also termed Class A basic helix-loop-helix protein 7 (bHLHa7), or protein atonal homolog 5 (ATOH5), is a neural-specific bHLH transcription factor expressed in the developing central nervous system and the embryonic pancreas. It is involved in neurogenesis and plays an important role in spermatogenesis.


Pssm-ID: 381434 [Multi-domain]  Cd Length: 57  Bit Score: 43.97  E-value: 2.89e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 23111009 110 RRKAATMRERRRLSKVNEAFETLKRCTSSNPNQ-RLPKVEILRNAIRYIEGLQALLR 165
Cdd:cd11428   1 RRLKANDRERNRMHNLNDALDALREVLPSFPDEtKLTKIETLRFAHNYIWALSETLK 57
bHLH_TS_HAND2 cd11471
basic helix-loop-helix (bHLH) domain found in heart- and neural crest derivatives-expressed ...
110-168 3.10e-06

basic helix-loop-helix (bHLH) domain found in heart- and neural crest derivatives-expressed protein 2 (HAND2) and similar proteins; HAND2, also termed Class A basic helix-loop-helix protein 26 (bHLHa26), or deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2 (dHAND), is a bHLH transcription factor that is essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries.


Pssm-ID: 381477 [Multi-domain]  Cd Length: 62  Bit Score: 43.90  E-value: 3.10e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 23111009 110 RRKAATMRERRRLSKVNEAFETLKRCTSSNP-NQRLPKVEILRNAIRYIEGLQALLRDQD 168
Cdd:cd11471   1 RRGTANRKERRRTQSINSAFAELRECIPNVPaDTKLSKIKTLRLATSYIAYLMDLLAKDD 60
bHLH_TS_dAS-C_like cd19744
basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster achaete-scute complex ...
110-164 3.25e-06

basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster achaete-scute complex (AS-C) proteins and similar proteins; Drosophila melanogaster AS-C proteins includes lethal of scute (also known as achaete-scute complex protein T3 or AST3), scute (also known as achaete-scute complex protein T4 or AST4), achaete (also known as achaete-scute complex protein T5 or AST5), and asense (also known as achaete-scute complex protein T8 or AST8). They are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system, as well as in sex determination and dosage compensation.


Pssm-ID: 381587 [Multi-domain]  Cd Length: 67  Bit Score: 44.12  E-value: 3.25e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 23111009 110 RRKAatmRERRRLSKVNEAFETLKR------CTS------SNPNQRLPKVEILRNAIRYIEGLQALL 164
Cdd:cd19744   4 RRNA---RERNRVKQVNNGFAILRQhipqsvIEDltagggRGKSKKLSKVDTLRMAVEYIRRLQKLL 67
bHLH_TS_NeuroD cd11427
basic helix-loop-helix (bHLH) domain found in neurogenic differentiation factor (NeuroD) ...
111-164 3.52e-06

basic helix-loop-helix (bHLH) domain found in neurogenic differentiation factor (NeuroD) family; The NeuroD family includes NeuroD1, NeuroD2, NeuroD4 and NeuroD6. NeuroD1, also termed Class A basic helix-loop-helix protein 3 (bHLHa3), is a neuronal bHLH transcription factor involved in the development and maintenance of the endocrine pancreas and neuronal elements. It acts as an essential regulator of glutamatergic neuronal differentiation. Loss of NeuroD1 causes ataxia, cerebellar hypoplasia, sensorineural deafness, and severe retinal dystrophy in mice. NeuroD2, also termed Class A basic helix-loop-helix protein 1 (bHLHa1), or NeuroD-related factor (NDRF), is a neuronal calcium-dependent bHLH transcription factor that induces neuronal differentiation and promotes neuronal survival. It plays a central role in thalamocortical synaptic maturation. NeuroD2 mediates calcium-dependent transcription activation by binding to E box-containing promoter. NeuroD4, also termed Class A basic helix-loop-helix protein 4 (bHLHa4), or protein atonal homolog 3 (ATH-3), or Atoh3, or Math-3, is a bHLH transcriptional activator that mediates neuronal differentiation. NeuroD6, also termed Class A basic helix-loop-helix protein 2 (bHLHa2), or protein atonal homolog 2 (ATH-2), or Atoh2, or Math2, or Nex1, is a neurogenic bHLH transcription factor involved in neuronal development, differentiation, and survival in Alzheimer's disease (AD) brains of both cohorts. It plays an integrative role in coordinating increase in mitochondrial mass with cytoskeletal remodeling, suggesting that it may act as a co-regulator of neuronal differentiation and energy metabolism.


Pssm-ID: 381433 [Multi-domain]  Cd Length: 55  Bit Score: 43.54  E-value: 3.52e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 23111009 111 RKAATMRERRRLSKVNEAFETLKR---CTSsnPNQRLPKVEILRNAIRYIEGLQALL 164
Cdd:cd11427   1 RVKANARERNRMHGLNDALDNLRKvvpCYS--KTQKLSKIETLRLARNYIWALSEIL 55
bHLH_TS_amos_like cd19715
basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster protein Amos and similar ...
110-164 4.12e-06

basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster protein Amos and similar proteins; Amos, also termed absent MD neurons and olfactory sensilla protein, or reduced olfactory organs protein, or rough eye protein, is a bHLH transcription factor that promotes multiple dendritic neuron formation in the Drosophila peripheral nervous system.


Pssm-ID: 381558 [Multi-domain]  Cd Length: 64  Bit Score: 43.67  E-value: 4.12e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 23111009 110 RRKAATMRERRRLSKVNEAFETLKRCTSSNPN-QRLPKVEILRNAIRYIEGLQALL 164
Cdd:cd19715   8 RRLAANARERRRMNSLNVAFDKLRDVVPSLGDdRKLSKYETLQMAQSYITALKELL 63
bHLH_TS_TWIST2 cd19700
basic helix-loop-helix (bHLH) domain found in twist-related protein 2 (TWIST2) and similar ...
109-168 4.81e-06

basic helix-loop-helix (bHLH) domain found in twist-related protein 2 (TWIST2) and similar proteins; TWIST2, also termed Class A basic helix-loop-helix protein 39 (bHLHa39), or Dermis-expressed protein 1, or Dermo-1, is a bHLH transcription factor that regulates the development of mesenchymal tissues and plays a critical role in embryogenesis. It binds to the E-box consensus sequence 5'-CANNTG-3' as a heterodimer and inhibits transcriptional activation by MYOD1, MYOG, MEF2A and MEF2C.


Pssm-ID: 381543 [Multi-domain]  Cd Length: 82  Bit Score: 44.01  E-value: 4.81e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 23111009 109 DRRKAATMRERRRLSKVNEAFETLKRCTSSNPNQRLPKVEILRNAIRYIEGLQALLRDQD 168
Cdd:cd19700  16 SQRILANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFLYQVLQSDE 75
bHLH_TS_NeuroD2 cd19720
basic helix-loop-helix (bHLH) domain found in neurogenic differentiation factor 2 (NeuroD2) ...
102-165 6.09e-06

basic helix-loop-helix (bHLH) domain found in neurogenic differentiation factor 2 (NeuroD2) and similar proteins; NeuroD2, also termed Class A basic helix-loop-helix protein 1 (bHLHa1), or NeuroD-related factor (NDRF), is a neuronal calcium-dependent bHLH transcription factor that induces neuronal differentiation and promotes neuronal survival. It plays a central role in thalamocortical synaptic maturation. NeuroD2 mediates calcium-dependent transcription activation by binding to E box-containing promoter.


Pssm-ID: 381563 [Multi-domain]  Cd Length: 93  Bit Score: 43.90  E-value: 6.09e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 23111009 102 KRKTTNAD------RRKAATMRERRRLSKVNEAFETLKR---CTSSnpNQRLPKVEILRNAIRYIEGLQALLR 165
Cdd:cd19720  21 KRKMTKARlersklRRQKANARERNRMHDLNSALDNLRKvvpCYSK--TQKLSKIETLRLAKNYIWALSEILR 91
bHLHzip_TFAP4 cd11419
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor AP-4 (TFAP4) and ...
110-162 7.86e-06

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor AP-4 (TFAP4) and similar proteins; TFAP4, also termed activating enhancer-binding protein 4, or Class C basic helix-loop-helix protein 41 (bHLHc41), is a bHLHzip transcription factor that activates both viral and cellular genes involved in the regulation of cellular proliferation, stemness, and epithelial-mesenchymal transition by binding to the symmetrical DNA sequence 5'-CAGCTG-3'.


Pssm-ID: 381425  Cd Length: 61  Bit Score: 42.68  E-value: 7.86e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 23111009 110 RRKAATMRERRRLSKVNEAFETLKRCTSSNPNQRLPKVEILRNAIRYIEGLQA 162
Cdd:cd11419   4 RREIANSNERRRMQSINAGFQSLRTLLPHCDGEKLSKAAILQQTAEYIFSLEQ 56
bHLH_TS_NeuroD4_ATOH3 cd19721
basic helix-loop-helix (bHLH) domain found in neurogenic differentiation factor 4 (NeuroD4) ...
102-165 8.18e-06

basic helix-loop-helix (bHLH) domain found in neurogenic differentiation factor 4 (NeuroD4) and similar proteins; NeuroD4, also termed Class A basic helix-loop-helix protein 4 (bHLHa4), or protein atonal homolog 3 (ATH-3), or Atoh3, or Math-3, is a bHLH transcriptional activator that mediates neuronal differentiation.


Pssm-ID: 381564 [Multi-domain]  Cd Length: 87  Bit Score: 43.53  E-value: 8.18e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 23111009 102 KRKTTNAD------RRKAATMRERRRLSKVNEAFETLKR---CTSSnpNQRLPKVEILRNAIRYIEGLQALLR 165
Cdd:cd19721  16 KKKMTKARlerfraRRVKANARERSRMHGLNDALDNLRRvmpCYSK--TQKLSKIETLRLARNYIWALSEVLE 86
bHLHzip_MGA_like cd19682
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MAX gene-associated protein (MGA) ...
111-161 1.23e-05

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MAX gene-associated protein (MGA) family; The MGA family includes MGA, Schizosaccharomyces pombe ESC1 (spESC1) and similar proteins. MGA, also termed MAX dimerization protein 5 (MAD5), is a dual specificity T-box/ bHLHzip transcription factor that regulates the expression of both Max-network and T-box family target genes. It contains a Myc-like bHLHZip motif and requires heterodimerization with Max for binding to the preferred Myc-Max-binding site CACGTG. In addition to the bHLHZip domain, MGA harbors a second DNA-binding domain, the T-box or T-domain. It thus binds the preferred Brachyury-binding sequence and represses transcription of reporter genes containing promoter-proximal Brachyury-binding sites. spESC1 is a bHLHzip protein with homology to human MyoD and Myf-5 myogenic differentiation inducers. It is involved in the sexual differentiation process.


Pssm-ID: 381525 [Multi-domain]  Cd Length: 65  Bit Score: 42.26  E-value: 1.23e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 23111009 111 RKAATMRERRRLSKVNEAFETLKRCTSSNPNQRLPKVEILRNAIRYIEGLQ 161
Cdd:cd19682   1 RLRHKKRERERRSELRELFDKLKQLLGLDSDEKASKLAVLTEAIEEIQQLK 51
bHLH_TS_HEN cd11414
basic helix-loop-helix (bHLH) domain found in helix-loop-helix protein (HEN) family; The HEN ...
111-164 1.29e-05

basic helix-loop-helix (bHLH) domain found in helix-loop-helix protein (HEN) family; The HEN family includes two neuron-specific bHLH transcription factors, HEN-1 (also known as Nhlh1 or bHLHa35 or NSCL-1) and HEN-2 (also known as Nhlh2 or bHLHa34 or NSCL-2). They may serve as DNA-binding protein that is involved in the control of cell-type determination, possibly within the developing nervous system.


Pssm-ID: 381420  Cd Length: 57  Bit Score: 42.12  E-value: 1.29e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 23111009 111 RKAATMRERRRLSKVNEAFETLKRCTSS-NPNQRLPKVEILRNAIRYIEGLQALL 164
Cdd:cd11414   3 RNAHATRERIRVEAFNSAFAQLRKLLPTlPPDKKLSKIEILRLAICYISYLNHVL 57
bHLH_TS_NGN2_ATOH4 cd19717
basic helix-loop-helix (bHLH) domain found in neurogenin-2 (NGN-2) and similar proteins; NGN-2, ...
110-168 1.68e-05

basic helix-loop-helix (bHLH) domain found in neurogenin-2 (NGN-2) and similar proteins; NGN-2, also termed Class A basic helix-loop-helix protein 8 (bHLHa8), or protein atonal homolog 4 (ATOH4), is a neural-specific bHLH transcription factor required for sensory neurogenesis. It activates transcription by binding to the E box (5'-CANNTG-3').


Pssm-ID: 381560 [Multi-domain]  Cd Length: 69  Bit Score: 42.31  E-value: 1.68e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 23111009 110 RRKAATMRERRRLSKVNEAFETLKRCTSSNP-NQRLPKVEILRNAIRYIEGLQALLRDQD 168
Cdd:cd19717  10 RRVKANNRERNRMHNLNAALDSLREVLPTFPeDAKLTKIETLRFAHNYIWALSETLRLAD 69
bHLH_TS_TCF15_paraxis cd11470
basic helix-loop-helix (bHLH) domain found in transcription factor 15 (TCF-15) and similar ...
110-164 1.86e-05

basic helix-loop-helix (bHLH) domain found in transcription factor 15 (TCF-15) and similar proteins; TCF-15, also termed Class A basic helix-loop-helix protein 40 (bHLHa40), or paraxis, or protein bHLH-EC2, is a bHLH transcription factor expressed in caudal lateral and paraxial mesoderm dermomyotome and sclerotome fore limb buds during embryo development. It may function as an early transcriptional regulator involved in the patterning of the mesoderm and in lineage determination of cell types derived from the mesoderm.


Pssm-ID: 381476 [Multi-domain]  Cd Length: 66  Bit Score: 41.99  E-value: 1.86e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 23111009 110 RRKAATMRERRRLSKVNEAFETLKRCTSSNP-NQRLPKVEILRNAIRYIEGLQALL 164
Cdd:cd11470   8 QRQAANARERDRTQSVNTAFTALRTLIPTEPvDRKLSKIETLRLASSYIAHLANVL 63
bHLH_TS_ASCL4 cd19746
basic helix-loop-helix (bHLH) domain found in achaete-scute-like protein 4 (ASCL-4) and ...
117-164 1.89e-05

basic helix-loop-helix (bHLH) domain found in achaete-scute-like protein 4 (ASCL-4) and similar proteins; ASCL-4, also termed Class A basic helix-loop-helix protein 44 (bHLHa44), or achaete-scute homolog 4 (ASH-4), or Hash4, is a bHLH transcriptional regulator that may be involved in skin development.


Pssm-ID: 381589  Cd Length: 64  Bit Score: 41.94  E-value: 1.89e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 23111009 117 RERRRLSKVNEAFETLKRCTSSN-PNQRLPKVEILRNAIRYIEGLQALL 164
Cdd:cd19746  15 RERQRVRCVNEGYARLREHLPQElADKRLSKVETLRAAIDYIKHLQELL 63
bHLH_TS_Mesp_like cd11425
basic helix-loop-helix (bHLH) domain found in mesoderm posterior protein (Mesp) family; Mesp, ...
110-164 2.50e-05

basic helix-loop-helix (bHLH) domain found in mesoderm posterior protein (Mesp) family; Mesp, a bHLH tissue specific transcription factor, acts as a key regulator of the cardiovascular transcriptional network by inducing directly and/or indirectly the expression of the majority of key cardiovascular transcription factors. The Mesp family includes two bHLH transcription factors, Mesp1 and Mesp2. Mesp1, also termed Class C basic helix-loop-helix protein 5 (bHLHc5), promotes cardiovascular differentiation during embryonic development and embryonic stem cell differentiation. Mesp2, also termed Class C basic helix-loop-helix protein 6 (bHLHc6), plays an important role in somitogenesis. The family also includes mesogenin-1 (Msgn1) and similar proteins. Msgn1, also termed paraxial mesoderm-specific mesogenin1, or pMesogenin1 (pMsgn1), is a bHLH transcription factor required for maturation and segmentation of paraxial mesoderm. It may regulate the expression of T-box transcription factors essential for mesoderm formation and differentiation.


Pssm-ID: 381431 [Multi-domain]  Cd Length: 59  Bit Score: 41.32  E-value: 2.50e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 23111009 110 RRKAATMRERRRLSKVNEAFETLKRC---TSSNPNQRLPKVEILRNAIRYIEGLQALL 164
Cdd:cd11425   1 QRQLANERERLRMRTLADALGELRQHlppSVAPKGKRLSKIQTLKYAIRYIGYLGNVL 58
bHLH_TS_NGN3_ATOH5 cd19718
basic helix-loop-helix (bHLH) domain found in neurogenin-3 (NGN-3) and similar proteins; NGN-3, ...
109-168 3.16e-05

basic helix-loop-helix (bHLH) domain found in neurogenin-3 (NGN-3) and similar proteins; NGN-3, also termed Class A basic helix-loop-helix protein 7 (bHLHa7), or protein atonal homolog 5 (ATOH5), is a neural-specific bHLH transcription factor expressed in the developing central nervous system and the embryonic pancreas. It is involved in neurogenesis and plays an important role in spermatogenesis.


Pssm-ID: 381561 [Multi-domain]  Cd Length: 68  Bit Score: 41.17  E-value: 3.16e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 23111009 109 DRRKAATMRERRRLSKVNEAFETLKRCTSSNPNQ-RLPKVEILRNAIRYIEGLQALLRDQD 168
Cdd:cd19718   7 NRRMKANDRERNRMHNLNSALDALRSVLPTFPDDaKLTKIETLRFAHNYIWALTETLRMAD 67
bHLH_TS_HAND1 cd18952
basic helix-loop-helix (bHLH) domain found in heart- and neural crest derivatives-expressed ...
110-164 3.65e-05

basic helix-loop-helix (bHLH) domain found in heart- and neural crest derivatives-expressed protein 1 (HAND1) and similar proteins; HAND1, also termed Class A basic helix-loop-helix protein 27 (bHLHa27), or extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1 (eHAND), is a bHLH transcription factor that plays an essential role in both trophoblast-giant cells differentiation and in cardiac morphogenesis.


Pssm-ID: 381522 [Multi-domain]  Cd Length: 60  Bit Score: 40.78  E-value: 3.65e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 23111009 110 RRKAATMRERRRLSKVNEAFETLKRCTSSNP-NQRLPKVEILRNAIRYIEGLQALL 164
Cdd:cd18952   2 RKGAGPKKERRRTESINSAFAELRECIPNVPaDTKLSKIKTLRLATSYIAYLMDVL 57
bHLH_TS_HEN1 cd19701
basic helix-loop-helix (bHLH) domain found in helix-loop-helix protein 1 (HEN-1) and similar ...
102-164 7.66e-05

basic helix-loop-helix (bHLH) domain found in helix-loop-helix protein 1 (HEN-1) and similar proteins; HEN-1, also termed nescient helix-loop-helix 1 (Nhlh1), or Class A basic helix-loop-helix protein 35 (bHLHa35), or nescient helix loop helix 1 (NSCL-1), is a neuron-specific bHLH transcription factor that may serve as DNA-binding protein and may be involved in the control of cell-type determination, possibly within the developing nervous system.


Pssm-ID: 381544 [Multi-domain]  Cd Length: 72  Bit Score: 40.41  E-value: 7.66e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 23111009 102 KRKTTNADRRKAATMRERRRLSKVNEAFETLKRCTSS-NPNQRLPKVEILRNAIRYIEGLQALL 164
Cdd:cd19701   8 RRRRATAKYRTAHATRERIRVEAFNVAFAELRKLLPTlPPDKKLSKIEILRLAICYISYLNHVL 71
bHLH_TS_MIST1 cd19711
basic helix-loop-helix (bHLH) domain found in muscle, intestine and stomach expression 1 ...
110-164 1.05e-04

basic helix-loop-helix (bHLH) domain found in muscle, intestine and stomach expression 1 (MIST-1) and similar proteins; MIST-1, also termed Class A basic helix-loop-helix protein 15 (bHLHa15), or Class B basic helix-loop-helix protein 8 (bHLHb8), is a bHLH transcription factor expressed in pancreatic acinar cells and other serous exocrine cells. It is essential for cytoskeletal organization and secretory activity. It also functions as a potent endoplasmic reticulum (ER) stress-inducible transcriptional regulator. MIST-1 is capable of binding to E-box (CANNTG) motifs as a homodimer or a heterodimer with E-proteins (E12 and E47) to regulate transcription.


Pssm-ID: 381554  Cd Length: 62  Bit Score: 39.70  E-value: 1.05e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 23111009 110 RRKAATMRERRRLSKVNEAFETLKRCTSS-NPNQRLPKVEILRNAIRYIEGLQALL 164
Cdd:cd19711   1 RRLESNERERQRMHKLNNAFQALREVIPHvRAEKKLSKIETLTLAKNYIKSLTTTI 56
bHLH_TS_HEN2 cd19702
basic helix-loop-helix (bHLH) domain found in helix-loop-helix protein 2 (HEN-2) and similar ...
102-164 1.09e-04

basic helix-loop-helix (bHLH) domain found in helix-loop-helix protein 2 (HEN-2) and similar proteins; HEN-2, also termed nescient helix-loop-helix 2 (Nhlh2), or Class A basic helix-loop-helix protein 34 (bHLHa34), or nescient helix loop helix 2 (NSCL-2), is a neuron-specific bHLH transcription factor that may serve as DNA-binding protein and may be involved in the control of cell-type determination, possibly within the developing nervous system.


Pssm-ID: 381545 [Multi-domain]  Cd Length: 73  Bit Score: 40.07  E-value: 1.09e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 23111009 102 KRKTTNADRRKAATMRERRRLSKVNEAFETLKRCTSS-NPNQRLPKVEILRNAIRYIEGLQALL 164
Cdd:cd19702   8 RRRRATAKYRSAHATRERIRVEAFNLAFAELRKLLPTlPPDKKLSKIEILRLAICYISYLNHVL 71
bHLHzip_Myc cd11400
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in the Myc family; The Myc family is a ...
118-162 1.44e-04

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in the Myc family; The Myc family is a member of the bHLHzip family of transcription factors that play important roles in the control of normal cell proliferation, growth, survival and differentiation. All Myc isoforms contain two independently functioning polypeptide chain regions: N-terminal transactivating residues and a C-terminal bHLHzip segment. The bHLHzip family of bHLH transcription factors are characterized by a highly conserved N-terminal basic region that may bind DNA at a consensus hexanucleotide sequence known as the E-box (CANNTG) followed by HLH and leucine zipper motifs that may interact with other proteins to form homo- and heterodimers. Myc heterodimerizes with Max enabling specific binding to E-box DNA sequences in the promoters of target genes. The Myc proto-oncoprotein family includes at least five different functional members: c-, N-, L-, S- and B-Myc (which is lacking the bHLH domain).


Pssm-ID: 381406 [Multi-domain]  Cd Length: 80  Bit Score: 39.84  E-value: 1.44e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 23111009 118 ERRRLSKVNEAFETLKRC---TSSNPnqRLPKVEILRNAIRYIEGLQA 162
Cdd:cd11400   9 ERQRRNDLKNSFEKLRDLvpeLADNE--KASKVVILKKATEYIKQLQQ 54
bHLH_TS_HAND cd11466
basic helix-loop-helix (bHLH) domain found in heart- and neural crest derivatives-expressed ...
110-164 1.68e-04

basic helix-loop-helix (bHLH) domain found in heart- and neural crest derivatives-expressed protein (HAND) family; The HAND family includes two bHLH transcription factors, HAND1 and HAND2. HAND1, also termed Class A basic helix-loop-helix protein 27 (bHLHa27), or extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1 (eHAND), plays an essential role in both trophoblast-giant cells differentiation and in cardiac morphogenesis. HAND2, also termed Class A basic helix-loop-helix protein 26 (bHLHa26), or deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2 (dHAND), is essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries.


Pssm-ID: 381472 [Multi-domain]  Cd Length: 56  Bit Score: 38.93  E-value: 1.68e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 23111009 110 RRKAATMRERRRLSKVNEAFETLKRCTSSNP-NQRLPKVEILRNAIRYIEGLQALL 164
Cdd:cd11466   1 RRGSANKKERRRTQSINSAFADLRECIPNVPaDTKLSKIKTLRLATSYIAYLMDVL 56
bHLH_E-protein_E47-like cd18943
basic helix-loop-helix (bHLH) domain found in transcription factor E47 and similar proteins; ...
102-168 1.86e-04

basic helix-loop-helix (bHLH) domain found in transcription factor E47 and similar proteins; E47 is a class I bHLH transcriptional regulator that forms heterodimers with class II bHLH proteins to regulate distinct differentiation pathways. Its homodimers regulate B lymphocytes development.


Pssm-ID: 381513  Cd Length: 74  Bit Score: 39.26  E-value: 1.86e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 23111009 102 KRKTTNADRRKAATMRERRRLSKVNEAFETLKRCTSSN--PNQRLPKVEILRNAIRYIEGLQALLRDQD 168
Cdd:cd18943   2 EKDLRDRERRMANNARERVRVRDINEAFKELGRMCQMHlkSDKAQTKLIILQQAVQVILGLEQQVRERN 70
bHLH_TS_Mesp cd18938
basic helix-loop-helix (bHLH) domain found in the mesoderm posterior protein (Mesp) family; ...
110-165 1.99e-04

basic helix-loop-helix (bHLH) domain found in the mesoderm posterior protein (Mesp) family; Mesp, a bHLH tissue specific transcription factor, acts as a key regulator of the cardiovascular transcriptional network by inducing directly and/or indirectly the expression of the majority of key cardiovascular transcription factors. The Mesp family includes two bHLH transcription factors, Mesp1 and Mesp2. Mesp1, also termed Class C basic helix-loop-helix protein 5 (bHLHc5), promotes cardiovascular differentiation during embryonic development and embryonic stem cell differentiation. Mesp2, also termed Class C basic helix-loop-helix protein 6 (bHLHc6), plays an important role in somitogenesis.


Pssm-ID: 381508 [Multi-domain]  Cd Length: 65  Bit Score: 39.11  E-value: 1.99e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 23111009 110 RRKAATMRERRRLSKVNEAFETLKRC---TSSNPNQRLPKVEILRNAIRYIEGLQALLR 165
Cdd:cd18938   1 QRQSASEREKLRMRDLAKALHNLRRYlppSVAPAGQSLTKIETLRLTIRYISHLSAQLG 59
bHLH_TS_Msgn1 cd18939
basic helix-loop-helix (bHLH) domain found in mesogenin-1 (Msgn1) and similar proteins; Msgn1, ...
107-164 2.07e-04

basic helix-loop-helix (bHLH) domain found in mesogenin-1 (Msgn1) and similar proteins; Msgn1, also termed paraxial mesoderm-specific mesogenin1, or pMesogenin1 (pMsgn1), is a bHLH transcription factor required for maturation and segmentation of paraxial mesoderm. It may regulate the expression of T-box transcription factors essential for mesoderm formation and differentiation.


Pssm-ID: 381509  Cd Length: 66  Bit Score: 39.12  E-value: 2.07e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 23111009 107 NADRRKAATMRERRRLSKVNEAFETLKRCTSSNPNQR---LPKVEILRNAIRYIEGLQALL 164
Cdd:cd18939   5 SAQRRRKASEREKLRMRTLAEALHTLRNYLPPVYSQRgqpLTKIQTLKCTIQYISELSGLL 65
bHLH_TS_NGN1_NeuroD3 cd19716
basic helix-loop-helix (bHLH) domain found in neurogenin-1 (NGN-1) and similar proteins; NGN-1, ...
105-168 2.10e-04

basic helix-loop-helix (bHLH) domain found in neurogenin-1 (NGN-1) and similar proteins; NGN-1, also termed Class A basic helix-loop-helix protein 6 (bHLHa6), or neurogenic basic-helix-loop-helix protein, or neurogenic differentiation factor 3 (NeuroD3), is a neural-specific bHLH transcription factor involved in the initiation of neuronal differentiation. It activates transcription by binding to the E box (5'-CANNTG-3').


Pssm-ID: 381559 [Multi-domain]  Cd Length: 77  Bit Score: 39.24  E-value: 2.10e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 23111009 105 TTNADRRKAATMRERRRLSKVNEAFETLKRCTSSNPNQ-RLPKVEILRNAIRYIEGLQALLRDQD 168
Cdd:cd19716  12 TIKKSRRVKANDRERNRMHNLNAALDELRSVLPSFPDDtKLTKIETLRFAHNYIWALSETLRLAD 76
bHLH_E-protein_E2A_TCF3 cd18944
basic helix-loop-helix (bHLH) domain found in transcription factor E2-alpha (E2A) and similar ...
109-168 2.30e-04

basic helix-loop-helix (bHLH) domain found in transcription factor E2-alpha (E2A) and similar proteins; E2A, also termed Class B basic helix-loop-helix protein 21 (bHLHb21), or immunoglobulin enhancer-binding factor E12/E47, or immunoglobulin transcription factor 1, or Kappa-E2-binding factor, or transcription factor 3 (TCF-3), or transcription factor ITF-1, is a bHLH transcriptional regulator involved in the initiation of neuronal differentiation.


Pssm-ID: 381514  Cd Length: 74  Bit Score: 39.24  E-value: 2.30e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 23111009 109 DRRKAATMRERRRLSKVNEAFETLKRCTSSNPNQRLP--KVEILRNAIRYIEGLQALLRDQD 168
Cdd:cd18944   1 ERRVANNARERLRVRDINEAFKELGRMCQLHLNSEKPqtKLLILHQAVSVILNLEQQVRERN 62
bHLH_TS_NeuroD1 cd19719
basic helix-loop-helix (bHLH) domain found in neurogenic differentiation factor 1 (NeuroD1) ...
102-165 3.88e-04

basic helix-loop-helix (bHLH) domain found in neurogenic differentiation factor 1 (NeuroD1) and similar proteins; NeuroD1, also termed Class A basic helix-loop-helix protein 3 (bHLHa3), is a neuronal bHLH transcription factor involved in the development and maintenance of the endocrine pancreas and neuronal elements. It acts as an essential regulator of glutamatergic neuronal differentiation. Loss of NeuroD1 causes ataxia, cerebellar hypoplasia, sensorineural deafness, and severe retinal dystrophy in mice.


Pssm-ID: 381562  Cd Length: 86  Bit Score: 38.62  E-value: 3.88e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 23111009 102 KRKTTNAD------RRKAATMRERRRLSKVNEAFETLKRCTSS-NPNQRLPKVEILRNAIRYIEGLQALLR 165
Cdd:cd19719  14 KKKMTKARlerfkmRRMKANARERNRMHGLNAALDNLRKVVPCySKTQKLSKIETLRLAKNYIWALSEILR 84
bHLH_AtBIM_like cd11453
basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana BES1-interacting Myc-like ...
118-166 6.10e-04

basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana BES1-interacting Myc-like proteins (BIMs) and similar proteins; The family includes Arabidopsis thaliana BIM1 and its homologs (BIM2 and BIM3), which are bHLH transcription factors that interact with BES1 to regulate transcription of Brassinosteroid (BR)-induced gene. BR regulates many growth and developmental processes such as cell elongation, vascular development, senescence stress responses, and photomorphogenesis. BIM1 heterodimerize with BES1 and bind to E-box sequences present in many BR-induced promoters to regulated BR-induced genes.


Pssm-ID: 381459  Cd Length: 77  Bit Score: 37.84  E-value: 6.10e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 23111009 118 ERRRLSKVNEAFETLkRCTSSNPNQRLPKVEILRNAIRYIEGLQALLRD 166
Cdd:cd11453  11 EQRRRSKINERLQAL-RDLIPHSDQKRDKASFLLEVIEYIQALQEKVAK 58
bHLH_TS_MIST1_like cd11426
basic helix-loop-helix (bHLH) domain found in muscle, intestine and stomach expression 1 ...
110-164 6.72e-04

basic helix-loop-helix (bHLH) domain found in muscle, intestine and stomach expression 1 (MIST-1) family; MIST-1, also termed Class A basic helix-loop-helix protein 15 (bHLHa15), or Class B basic helix-loop-helix protein 8 (bHLHb8), is a bHLH transcription factor expressed in pancreatic acinar cells and other serous exocrine cells. It is essential for cytoskeletal organization and secretory activity. It also functions as a potent endoplasmic reticulum (ER) stress-inducible transcriptional regulator. MIST-1 is capable of binding to E-box (CANNTG) motifs as a homodimer or a heterodimer with E-proteins (E12 and E47) to regulate transcription. The family also includes Drosophila melanogaster protein dimmed and similar proteins. Dimmed, also termed DIMM, is a bHLH transcription factor that regulates neurosecretory (NS) cell function and neuroendocrine cell fate in Drosophila.


Pssm-ID: 381432  Cd Length: 56  Bit Score: 37.19  E-value: 6.72e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 23111009 110 RRKAATMRERRRLSKVNEAFETLKR-CTSSNPNQRLPKVEILRNAIRYIEGLQALL 164
Cdd:cd11426   1 RRLESNERERLRMHQLNDAFQALREvIPHVRSERKLSKIETLTLAKNYIKSLTNMI 56
bHLH-O_HERP_like cd11389
basic helix-loop-helix-orange (bHLH-O) domain found in hairy and enhancer of split (HES) ...
118-164 7.39e-04

basic helix-loop-helix-orange (bHLH-O) domain found in hairy and enhancer of split (HES)-related repressor protein (HERP)-like family; The HERP-like family includes bHLH-O transcriptional regulators that are related to the Drosophila hairy and Enhancer-of-split proteins. They contain a basic helix-loop-helix (bHLH) domain with an invariant glycine residue in its basic region, an orange domain in the central region and YXXW sequence motif at its C-terminal region. HERP proteins (HEY1, HEY2 and HEYL) act as downstream effectors of Notch signaling. They are involved in cardiovascular development and have roles in somitogenesis, myogenesis and gliogenesis. Hairy and enhancer of split-related protein HELT is a transcriptional repressor expressed in the developing central nervous system. It binds preferentially to the canonical E box sequence 5'-CACGCG-3' and regulates neuronal differentiation and/or identity. Differentially expressed in chondrocytes proteins, DEC1 and DEC2, are widely expressed in both embryonic and adult tissues and have been implicated in apoptosis, cell proliferation, and circadian rhythms, as well as malignancy in various cancers. Drosophila melanogaster protein clockwork orange (Cwo) is also included in this family. It is involved in the regulation of Drosophila circadian rhythms. It functions as both an activator and a repressor of clock gene expression.


Pssm-ID: 381395 [Multi-domain]  Cd Length: 55  Bit Score: 36.92  E-value: 7.39e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 23111009 118 ERRRLSKVNEAFETLKR----CTSSNPNQRLPKVEILRNAIRYIEGLQALL 164
Cdd:cd11389   5 EKRRRDRINESLAELRRlvpeARKSKGSGKLEKAEILEMTLQHLKALQSST 55
bHLHzip_MGA cd18911
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MAX gene-associated protein (MGA) and ...
111-161 1.84e-03

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MAX gene-associated protein (MGA) and similar proteins; MGA, also termed MAX dimerization protein 5 (MAD5), is a dual specificity T-box/ bHLHzip transcription factor that regulates the expression of both Max-network and T-box family target genes. It contains a Myc-like bHLHZip motif and requires heterodimerization with Max for binding to the preferred Myc-Max-binding site CACGTG. In addition to the bHLHZip domain, MGA harbors a second DNA-binding domain, the T-box or T-domain. It thus binds the preferred Brachyury-binding sequence and represses transcription of reporter genes containing promoter-proximal Brachyury-binding sites.


Pssm-ID: 381481  Cd Length: 65  Bit Score: 36.30  E-value: 1.84e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 23111009 111 RKAATMRERRRLSKVNEAFETLKRCTSSNPNQRLPKVEILRNAIRYIEGLQ 161
Cdd:cd18911   1 RRTHTANERRRRNEMRDLFEKLKRTLGLHNLPKVSKYYILKQAFEEIQGLT 51
bHLH-O_HERP_HES cd19685
basic helix-loop-helix-orange (bHLH-O) domain found in HERP/HES-like family; The HERP/HES-like ...
118-162 1.95e-03

basic helix-loop-helix-orange (bHLH-O) domain found in HERP/HES-like family; The HERP/HES-like family includes bHLH-O transcriptional regulators that are related to the Drosophila hairy and Enhancer-of-split (HES) proteins. The HERP (HES-related repressor protein) subfamily proteins contain a basic helix-loop-helix (bHLH) domain with an invariant glycine residue in its basic region, an orange domain in the central region and YXXW sequence motif at its C-terminal region. Hairy and enhancer of split (HES)-related repressor protein (HERP) proteins (HEY1, HEY2 and HEYL) act as downstream effectors of Notch signaling. They are involved in cardiovascular development and have roles in somitogenesis, myogenesis and gliogenesis. Hairy and enhancer of split-related protein HELT is a transcriptional repressor expressed in the developing central nervous system. It binds preferentially to the canonical E box sequence 5'-CACGCG-3' and regulates neuronal differentiation and/or identity. Differentially expressed in chondrocytes proteins, DEC1 and DEC2, are widely expressed in both embryonic and adult tissues and have been implicated in apoptosis, cell proliferation, and circadian rhythms, as well as malignancy in various cancers. Drosophila melanogaster protein clockwork orange (Cwo) is also included in this subfamily. It is involved in the regulation of Drosophila circadian rhythms. It functions as both an activator and a repressor of clock gene expression. The HES subfamily proteins contain a basic helix-loop-helix (bHLH) domain with an invariant proline residue in its basic region, an orange domain in the central region and a conserved tetrapeptide motif, WRPW, at its C-terminal region. They form heterodimers or homodimers via their HLH domain and bind DNA to repress gene transcription that play an essential role in development of both compartment and boundary cells of the central nervous system.


Pssm-ID: 381528 [Multi-domain]  Cd Length: 52  Bit Score: 35.86  E-value: 1.95e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 23111009 118 ERRRLSKVNEAFETLKR----CTSSNPNQRLPKVEILRNAIRYIEGLQA 162
Cdd:cd19685   2 EKRRRQRINDKLNQLKEllppNLSKQSRSKLSKAEILEMAITELRRLQQ 50
bHLH_TS_scleraxis cd18951
basic helix-loop-helix (bHLH) domain found in scleraxis and similar proteins; Scleraxis, also ...
110-164 2.95e-03

basic helix-loop-helix (bHLH) domain found in scleraxis and similar proteins; Scleraxis, also termed SCX, or Class A basic helix-loop-helix protein 41 (bHLHa41), or Class A basic helix-loop-helix protein 48 (bHLHa48), is a bHLH transcription factor that is expressed in sclerotome limb bud cranial and body wall mesenchyme, pericardium and heart valves, ligaments and tendons. It is required for tendon formation ligaments, connective tissue, the diaphragm, and testis development. Scleraxis plays a central role in promoting fibroblast proliferation and matrix synthesis during the embryonic development of tendons.


Pssm-ID: 381521 [Multi-domain]  Cd Length: 68  Bit Score: 35.90  E-value: 2.95e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 23111009 110 RRKAATMRERRRLSKVNEAFETLKRCTSSNPNQR-LPKVEILRNAIRYIEGLQALL 164
Cdd:cd18951   4 QRHTANARERDRTNSVNTAFTALRTLIPTEPADRkLSKIETLRLASSYISHLGNVL 59
bHLH_TS_TCF21_capsulin cd19704
basic helix-loop-helix (bHLH) domain found in transcription factor 21 (TCF-21) and similar ...
110-164 5.33e-03

basic helix-loop-helix (bHLH) domain found in transcription factor 21 (TCF-21) and similar proteins; TCF-21, also termed capsulin, or Class A basic helix-loop-helix protein 23 (bHLHa23), or epicardin, or podocyte-expressed 1 (Pod-1), is a bHLH transcription factor expressed specifically in mesodermally-derived cells that surround the epithelium of the developing gastrointestinal, genitourinary and respiratory systems during mouse embryogenesis. It may play a role in the specification or differentiation of one or more subsets of epicardial cell types.


Pssm-ID: 381547 [Multi-domain]  Cd Length: 64  Bit Score: 34.80  E-value: 5.33e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 23111009 110 RRKAATMRERRRLSKVNEAFETLKRCTS-SNPNQRLPKVEILRNAIRYIEGLQALL 164
Cdd:cd19704   4 QRNAANARERARMRVLSKAFSRLKTTLPwVPPDTKLSKLDTLRLASSYIAHLRQIL 59
bHLH_AtTT8_like cd11451
basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein transparent testa 8 ...
116-161 6.20e-03

basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein transparent testa 8 (TT8) and similar proteins; The family includes several bHLH transcription factors from Arabidopsis thaliana, such as TT8, EGL1, and GL3. TT8, also termed AtbHLH42, or EN 32, is involved in the control of flavonoid pigmentation and plays a key role in regulating leucoanthocyanidin reductase (BANYULS) and dihydroflavonol-4-reductase (DFR). EGL1, also termed AtbHLH2, or EN 30, or AtMYC146, or protein enhancer of GLABRA 3, is involved in epidermal cell fate specification and regulates negatively stomata formation but promotes trichome formation. GL3, also termed AtbHLH1, or AtMYC6, or protein shapeshifter, or EN 31, is involved in epidermal cell fate specification. It regulates negatively stomata formation, but, in association with TTG1 and MYB0/GL1, promotes trichome formation, branching and endoreplication.


Pssm-ID: 381457  Cd Length: 75  Bit Score: 35.09  E-value: 6.20e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 23111009 116 MRERRRLSKVNEAFETLKRCTSSnpNQRLPKVEILRNAIRYIEGLQ 161
Cdd:cd11451   8 MAERRRREKLNERFITLRSMVPF--VTKMDKVSILGDAIEYLKQLQ 51
bHLHzip_Mnt cd11402
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-binding protein Mnt and similar ...
111-168 6.55e-03

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-binding protein Mnt and similar proteins; Mnt, also termed Class D basic helix-loop-helix protein 3 (bHLHd3), or Myc antagonist MNT, or protein ROX, is a bHLHZip transcriptional repressor that binds DNA as a heterodimer with MAX. It binds to the canonical E box sequence 5'-CACGTG-3' and, with higher affinity, to 5'-CACGCG-3'. Mnt has an important role as an antagonist and regulator of Myc activities and it is a potential tumor suppressor. Mnt is ubiquitously expressed. Mnt-deficient mice shown to exhibit early postnatal lethality.


Pssm-ID: 381408 [Multi-domain]  Cd Length: 77  Bit Score: 34.99  E-value: 6.55e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 23111009 111 RKAATMRERRRLSKVNEAFETLKRCTSSNPNQRLPKVEILRNAIRYIEGLQALLRDQD 168
Cdd:cd11402   3 REVHNKLEKNRRAHLKECFETLKRQIPNLDDKKTSNLNILRSALRYIQILKRKEKEYE 60
bHLHzip_USF_MITF cd11387
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in USF/MITF family; The USF (upstream ...
118-165 6.91e-03

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in USF/MITF family; The USF (upstream stimulatory factor)/MITF (microphthalmia-associated transcription factor) family includes two bHLHzip transcription factor subfamilies. USFs are ubiquitously expressed and key regulators of a wide number of gene regulation networks, including the stress and immune responses, cell cycle and proliferation, lipid and glucid metabolism. USFs recruit chromatin remodeling enzymes and interact with co-activators and the members of the transcription pre-initiation complex. USFs interact with high affinity to E-box regulatory elements. The MITF (also known as microphthalmia-TFE, or MiT) subfamily comprises four genes in mammals (MITF, TFE3, TFEB, and TFEC); each gene has different functions. MITF is involved in neural crest melanocytes development as well as the pigmented retinal epithelium. TFEB is required for vascularization of the mouse placenta. TFE3 is involved in B cell function. TFEC regulates gene expression in macrophages. The MITF subfamily proteins can form homodimers or heterodimers with each other but not with other bHLH or bHLHzip proteins.


Pssm-ID: 381393 [Multi-domain]  Cd Length: 58  Bit Score: 34.54  E-value: 6.91e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 23111009 118 ERRRLSKVNEAFETLKRCTSSNP----NQRLPKVEILRNAIRYIEGLQALLR 165
Cdd:cd11387   6 ERRRRDNINEKIQELGSLVPPSRletkDLKPNKGSILSKAVEYIRELQNQNQ 57
bHLH_AtbHLH_like cd11393
basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana genes coding transcription ...
117-161 7.21e-03

basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana genes coding transcription factors and similar proteins; bHLH proteins are the second largest class of plant transcription factors that regulate transcription of genes that are involve in many essential physiological and developmental process. bHLH proteins are transcriptional regulators that are found in organisms from yeast to humans. The Arabidopsis bHLH proteins that have been characterized so far have roles in regulation of fruit dehiscence, cell development (carpel, anther and epidermal), phytochrome signaling, flavonoid biosynthesis, hormone signaling and stress responses.


Pssm-ID: 381399 [Multi-domain]  Cd Length: 53  Bit Score: 34.08  E-value: 7.21e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 23111009 117 RERRRLSKVNEAFETLKRCTSsnPNQRLPKVEILRNAIRYIEGLQ 161
Cdd:cd11393   4 AERKRREKINERIRALRSLVP--NGGKTDKASILDEAIEYIKFLQ 46
bHLH_TS_musculin cd19703
basic helix-loop-helix (bHLH) domain found in musculin and similar proteins; Musculin, also ...
110-166 7.60e-03

basic helix-loop-helix (bHLH) domain found in musculin and similar proteins; Musculin, also termed activated B-cell factor 1 (ABF-1), or Class A basic helix-loop-helix protein 22 (bHLHa22), is a bHLH transcription factor expressed in activated B lymphocytes. It acts as a transcription repressor capable of inhibiting the transactivation capability of TCF3/E47. Musculin may play a role in regulating antigen-dependent B-cell differentiation. The mouse homolog, musculin, is suggested to be a repressor of myogenesis that is expressed in developing muscle and in the spleen. Musculin heterodimerizes with products of the E2A gene.


Pssm-ID: 381546 [Multi-domain]  Cd Length: 66  Bit Score: 34.74  E-value: 7.60e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 23111009 110 RRKAATMRERRRLSKVNEAFETLKRCTS-SNPNQRLPKVEILRNAIRYIEGLQALLRD 166
Cdd:cd19703   4 QRNAANARERARMRVLSKAFSRLKTSLPwVPPDTKLSKLDTLRLASSYIAHLRQLLQE 61
bHLHzip_SREBP_like cd11395
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in sterol regulatory element-binding ...
110-161 8.05e-03

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in sterol regulatory element-binding protein (SREBP) family and similar proteins; The SREBP family includes SREBP1 and SREBP2, which are bHLHzip transcriptional activator of genes encoding proteins essential for cholesterol biosynthesis/uptake and fatty acid biosynthesis. SREBP1 and SREBP2 are principally found in the liver and in adipocytes and made up of an N-terminal transcription factor portion (composed of an activation domain, a bHLHzip domain, and a nuclear localization signal), a hydrophobic region containing two membrane spanning regions, and a C-terminal regulatory segment. They recognize a symmetric sterol regulatory element (TCACNCCAC) instead of E-box. The family also includes Saccharomyces cerevisiae transcription factor HMS1 (also termed high-copy MEP suppressor protein 1) and serine-rich protein TYE7. HMS1 is a putative bHLHzip transcription factor involved in exit from mitosis and pseudohyphal differentiation. TYE7, also termed basic-helix-loop-helix protein SGC1, is a putative bHLHzip transcription activator required for Ty1-mediated glycolytic gene expression. TYE7 N-terminal is extremely rich in serine residues. It binds DNA on E-box motifs, 5'-CANNTG-3'. TYE7 is not essential for growth.


Pssm-ID: 381401 [Multi-domain]  Cd Length: 87  Bit Score: 35.00  E-value: 8.05e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 23111009 110 RRKAATMRERRRLSKVNEAFETLKRC----------------TSSNPNQRLPKVEILRNAIRYIEGLQ 161
Cdd:cd11395   3 KRLPHNAIEKRYRSNLNTKIERLRDAipslrspegksddgglGGLAPTTKLSKATILTKAIEYIRHLE 70
bHLH_AtMYC1_like cd18918
basic Helix-Loop-Helix (bHLH) domain found in Arabidopsis thaliana MYC1 and similar proteins; ...
118-166 9.62e-03

basic Helix-Loop-Helix (bHLH) domain found in Arabidopsis thaliana MYC1 and similar proteins; MYC1, also termed AtbHLH12, or EN 58, acts as a transcription activator, when associated with MYB75/PAP1 or MYB90/PAP2.


Pssm-ID: 381488 [Multi-domain]  Cd Length: 70  Bit Score: 34.23  E-value: 9.62e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 23111009 118 ERRRLSKVNEAFETLkRCTSSNPNQRlPKVEILRNAIRYIEGLQALLRD 166
Cdd:cd18918   5 ERERREKLNEKFSDL-RNLIPNPTKN-DRASILSDAIKYINELQRTVEE 51
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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