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Conserved domains on  [gi|1514769207|ref|NP_002519|]
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endonuclease III-like protein 1 isoform 1 [Homo sapiens]

Protein Classification

endonuclease III domain-containing protein( domain architecture ID 11415064)

endonuclease III domain-containing protein such as endonuclease III, a DNA repair enzyme that has both DNA N-glycosylase and AP-lyase activities

CATH:  1.10.1670.10
Gene Ontology:  GO:0016798|GO:0006284|GO:0051539
PubMed:  10908318|1411536
SCOP:  4001141

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Nth COG0177
Endonuclease III [Replication, recombination and repair];
122-302 2.23e-65

Endonuclease III [Replication, recombination and repair];


:

Pssm-ID: 439947 [Multi-domain]  Cd Length: 198  Bit Score: 203.79  E-value: 2.23e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514769207 122 YQVLLSLMLSSQTKDQVTAGAMQRLRARGLTVDSILQTDDATLGKLIYPVGFWRSKVKYIKQTSAILQQHYGGDIPASVA 201
Cdd:COG0177    21 FELLVATILSAQTTDERVNKATPRLFARYPTPEALAAADLEELEELIRPIGLYRNKAKNIIALARILVEKYGGEVPETRE 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514769207 202 ELVALPGVGPKMAHLAMAVAWGtVSGIAVDTHVHRIANRLRWTKkaTKSPEETRAALEEWLPRELWHEINGLLVGFGQQT 281
Cdd:COG0177   101 ELESLPGVGRKTANVVLNFAFG-KPAIAVDTHVHRVSNRLGLVP--GKDPEEVEKDLMKLIPKEYWGDLHHLLILHGRYI 177

                         170       180
                  ....*....|....*....|.
gi 1514769207 282 CLPVHPRCHACLNQALCPAAQ 302
Cdd:COG0177   178 CKARKPKCEECPLADLCPYYG 198
 
Name Accession Description Interval E-value
Nth COG0177
Endonuclease III [Replication, recombination and repair];
122-302 2.23e-65

Endonuclease III [Replication, recombination and repair];


Pssm-ID: 439947 [Multi-domain]  Cd Length: 198  Bit Score: 203.79  E-value: 2.23e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514769207 122 YQVLLSLMLSSQTKDQVTAGAMQRLRARGLTVDSILQTDDATLGKLIYPVGFWRSKVKYIKQTSAILQQHYGGDIPASVA 201
Cdd:COG0177    21 FELLVATILSAQTTDERVNKATPRLFARYPTPEALAAADLEELEELIRPIGLYRNKAKNIIALARILVEKYGGEVPETRE 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514769207 202 ELVALPGVGPKMAHLAMAVAWGtVSGIAVDTHVHRIANRLRWTKkaTKSPEETRAALEEWLPRELWHEINGLLVGFGQQT 281
Cdd:COG0177   101 ELESLPGVGRKTANVVLNFAFG-KPAIAVDTHVHRVSNRLGLVP--GKDPEEVEKDLMKLIPKEYWGDLHHLLILHGRYI 177

                         170       180
                  ....*....|....*....|.
gi 1514769207 282 CLPVHPRCHACLNQALCPAAQ 302
Cdd:COG0177   178 CKARKPKCEECPLADLCPYYG 198
ENDO3c smart00478
endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), ...
 130-279 2.42e-51

endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases


Pssm-ID: 214684 [Multi-domain]  Cd Length: 149  Bit Score: 165.90  E-value: 2.42e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514769207  130 LSSQTKDQVTAGAMQRLRARGLTVDSILQTDDATLGKLIYPVGFWRSKVKYIKQTSAILQQHYGGDIPASVAELVALPGV 209
Cdd:smart00478   1 LSQQTTDERVNKATERLFEKFPTPEDLAAADEEELEELIRGLGFYRRKARYLIELARILVEEYGGEVPDDREELLKLPGV 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514769207  210 GPKMAHLAMAVAWGTVsGIAVDTHVHRIANRLRWTKKaTKSPEETRAALEEWLPRELWHEINGLLVGFGQ 279
Cdd:smart00478  81 GRKTANAVLSFALGKP-FIPVDTHVLRIAKRLGLVDK-KSTPEEVEKLLEKLLPEEDWRELNLLLIDFGR 148
ENDO3c cd00056
endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), ...
 122-278 6.60e-48

endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases


Pssm-ID: 238013 [Multi-domain]  Cd Length: 158  Bit Score: 157.40  E-value: 6.60e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514769207 122 YQVLLSLMLSSQTKDQVTAGAMQRLRAR-GLTVDSILQTDDATLGKLIYPVGFwRSKVKYIKQTSAILQQHYGGDI---P 197
Cdd:cd00056     1 FEVLVSEILSQQTTDKAVNKAYERLFERyGPTPEALAAADEEELRELIRSLGY-RRKAKYLKELARAIVEGFGGLVlddP 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514769207 198 ASVAELVALPGVGPKMAHLAMAVAWGtVSGIAVDTHVHRIANRLRWTKKaTKSPEETRAALEEWLPRELWHEINGLLVGF 277
Cdd:cd00056    80 DAREELLALPGVGRKTANVVLLFALG-PDAFPVDTHVRRVLKRLGLIPK-KKTPEELEELLEELLPKPYWGEANQALMDL 157


                  .
gi 1514769207 278 G 278
Cdd:cd00056   158 G 158
nth TIGR01083
endonuclease III; This equivalog model identifes nth members of the pfam00730 superfamily ...
 122-289 3.82e-44

endonuclease III; This equivalog model identifes nth members of the pfam00730 superfamily (HhH-GPD: Helix-hairpin-helix and Gly/Pro rich loop followed by a conserved aspartate). The major members of the superfamily are nth and mutY. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273434 [Multi-domain]  Cd Length: 192  Bit Score: 149.07  E-value: 3.82e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514769207 122 YQVLLSLMLSSQTKDQVTAGAMQRLRARGLTVDSILQTDDATLGKLIYPVGFWRSKVKYIKQTSAILQQHYGGDIPASVA 201
Cdd:TIGR01083  28 FELLVATILSAQATDKRVNKATPKLFEVYPTPQALAQAGLEELEEYIKSIGLYRNKAKNIIELCRKLVERYGGEVPEDRE 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514769207 202 ELVALPGVGPKMAHLAMAVAWGtVSGIAVDTHVHRIANRLRWTKkaTKSPEETRAALEEWLPRELWHEINGLLVGFGQQT 281
Cdd:TIGR01083 108 ELVKLPGVGRKTANVVLNVAFG-IPAIAVDTHVFRVSNRLGLSK--GKDPIKVEEDLMKLVPREFWVKLHHWLILHGRYT 184


                  ....*...
gi 1514769207 282 CLPVHPRC 289
Cdd:TIGR01083 185 CKARKPLC 192
HhH-GPD pfam00730
HhH-GPD superfamily base excision DNA repair protein; This family contains a diverse range of ...
 126-264 7.04e-43

HhH-GPD superfamily base excision DNA repair protein; This family contains a diverse range of structurally related DNA repair proteins. The superfamily is called the HhH-GPD family after its hallmark Helix-hairpin-helix and Gly/Pro rich loop followed by a conserved aspartate. This includes endonuclease III, EC:4.2.99.18 and MutY an A/G-specific adenine glycosylase, both have a C terminal 4Fe-4S cluster. The family also includes 8-oxoguanine DNA glycosylases. The methyl-CPG binding protein MBD4 also contains a related domain that is a thymine DNA glycosylase. The family also includes DNA-3-methyladenine glycosylase II EC:3.2.2.21 and other members of the AlkA family.


Pssm-ID: 425841 [Multi-domain]  Cd Length: 141  Bit Score: 143.96  E-value: 7.04e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514769207 126 LSLMLSSQTKDQVTAGAMQRLRAR-GLTVDSILQTDDATLGKLIYPVGFWRSKVKYIKQTSAILQQHYGGDIPASVAELV 204
Cdd:pfam00730   1 VSAILSQQTSDKAVNKITERLFEKfFPTPEDLADADEEELRELIRGLGFYRRKAKYLKELARILVEGYGGEVPLDEEELE 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1514769207 205 A-LPGVGPKMAHLAMAVAWG-TVSGIAVDTHVHRIANRLRWTkKATKSPEETRAALEEWLPR 264
Cdd:pfam00730  81 AlLKGVGRWTAEAVLIFALGrPDPLPVVDTHVRRVLKRLGLI-KEKPTPKEVERELEELWPP 141
PRK10702 PRK10702
endonuclease III; Provisional
 122-298 6.81e-24

endonuclease III; Provisional


Pssm-ID: 182661 [Multi-domain]  Cd Length: 211  Bit Score: 96.62  E-value: 6.81e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514769207 122 YQVLLSLMLSSQTKDQVTAGAMQRLRARGLTVDSILQTDDATLGKLIYPVGFWRSKVKYIKQTSAILQQHYGGDIPASVA 201
Cdd:PRK10702   30 FELLIAVLLSAQATDVSVNKATAKLYPVANTPAAMLELGVEGVKTYIKTIGLYNSKAENVIKTCRILLEQHNGEVPEDRA 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514769207 202 ELVALPGVGPKMAHLAMAVAWGTVSgIAVDTHVHRIANRLRWTkkATKSPEETRAALEEWLPRELWHEINGLLVGFGQQT 281
Cdd:PRK10702  110 ALEALPGVGRKTANVVLNTAFGWPT-IAVDTHIFRVCNRTQFA--PGKNVEQVEEKLLKVVPAEFKVDCHHWLILHGRYT 186

                         170
                  ....*....|....*..
gi 1514769207 282 CLPVHPRCHACLNQALC 298
Cdd:PRK10702  187 CIARKPRCGSCIIEDLC 203
 
Name Accession Description Interval E-value
Nth COG0177
Endonuclease III [Replication, recombination and repair];
122-302 2.23e-65

Endonuclease III [Replication, recombination and repair];


Pssm-ID: 439947 [Multi-domain]  Cd Length: 198  Bit Score: 203.79  E-value: 2.23e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514769207 122 YQVLLSLMLSSQTKDQVTAGAMQRLRARGLTVDSILQTDDATLGKLIYPVGFWRSKVKYIKQTSAILQQHYGGDIPASVA 201
Cdd:COG0177    21 FELLVATILSAQTTDERVNKATPRLFARYPTPEALAAADLEELEELIRPIGLYRNKAKNIIALARILVEKYGGEVPETRE 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514769207 202 ELVALPGVGPKMAHLAMAVAWGtVSGIAVDTHVHRIANRLRWTKkaTKSPEETRAALEEWLPRELWHEINGLLVGFGQQT 281
Cdd:COG0177   101 ELESLPGVGRKTANVVLNFAFG-KPAIAVDTHVHRVSNRLGLVP--GKDPEEVEKDLMKLIPKEYWGDLHHLLILHGRYI 177

                         170       180
                  ....*....|....*....|.
gi 1514769207 282 CLPVHPRCHACLNQALCPAAQ 302
Cdd:COG0177   178 CKARKPKCEECPLADLCPYYG 198
ENDO3c smart00478
endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), ...
 130-279 2.42e-51

endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases


Pssm-ID: 214684 [Multi-domain]  Cd Length: 149  Bit Score: 165.90  E-value: 2.42e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514769207  130 LSSQTKDQVTAGAMQRLRARGLTVDSILQTDDATLGKLIYPVGFWRSKVKYIKQTSAILQQHYGGDIPASVAELVALPGV 209
Cdd:smart00478   1 LSQQTTDERVNKATERLFEKFPTPEDLAAADEEELEELIRGLGFYRRKARYLIELARILVEEYGGEVPDDREELLKLPGV 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514769207  210 GPKMAHLAMAVAWGTVsGIAVDTHVHRIANRLRWTKKaTKSPEETRAALEEWLPRELWHEINGLLVGFGQ 279
Cdd:smart00478  81 GRKTANAVLSFALGKP-FIPVDTHVLRIAKRLGLVDK-KSTPEEVEKLLEKLLPEEDWRELNLLLIDFGR 148
ENDO3c cd00056
endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), ...
 122-278 6.60e-48

endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases


Pssm-ID: 238013 [Multi-domain]  Cd Length: 158  Bit Score: 157.40  E-value: 6.60e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514769207 122 YQVLLSLMLSSQTKDQVTAGAMQRLRAR-GLTVDSILQTDDATLGKLIYPVGFwRSKVKYIKQTSAILQQHYGGDI---P 197
Cdd:cd00056     1 FEVLVSEILSQQTTDKAVNKAYERLFERyGPTPEALAAADEEELRELIRSLGY-RRKAKYLKELARAIVEGFGGLVlddP 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514769207 198 ASVAELVALPGVGPKMAHLAMAVAWGtVSGIAVDTHVHRIANRLRWTKKaTKSPEETRAALEEWLPRELWHEINGLLVGF 277
Cdd:cd00056    80 DAREELLALPGVGRKTANVVLLFALG-PDAFPVDTHVRRVLKRLGLIPK-KKTPEELEELLEELLPKPYWGEANQALMDL 157


                  .
gi 1514769207 278 G 278
Cdd:cd00056   158 G 158
nth TIGR01083
endonuclease III; This equivalog model identifes nth members of the pfam00730 superfamily ...
 122-289 3.82e-44

endonuclease III; This equivalog model identifes nth members of the pfam00730 superfamily (HhH-GPD: Helix-hairpin-helix and Gly/Pro rich loop followed by a conserved aspartate). The major members of the superfamily are nth and mutY. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273434 [Multi-domain]  Cd Length: 192  Bit Score: 149.07  E-value: 3.82e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514769207 122 YQVLLSLMLSSQTKDQVTAGAMQRLRARGLTVDSILQTDDATLGKLIYPVGFWRSKVKYIKQTSAILQQHYGGDIPASVA 201
Cdd:TIGR01083  28 FELLVATILSAQATDKRVNKATPKLFEVYPTPQALAQAGLEELEEYIKSIGLYRNKAKNIIELCRKLVERYGGEVPEDRE 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514769207 202 ELVALPGVGPKMAHLAMAVAWGtVSGIAVDTHVHRIANRLRWTKkaTKSPEETRAALEEWLPRELWHEINGLLVGFGQQT 281
Cdd:TIGR01083 108 ELVKLPGVGRKTANVVLNVAFG-IPAIAVDTHVFRVSNRLGLSK--GKDPIKVEEDLMKLVPREFWVKLHHWLILHGRYT 184


                  ....*...
gi 1514769207 282 CLPVHPRC 289
Cdd:TIGR01083 185 CKARKPLC 192
HhH-GPD pfam00730
HhH-GPD superfamily base excision DNA repair protein; This family contains a diverse range of ...
 126-264 7.04e-43

HhH-GPD superfamily base excision DNA repair protein; This family contains a diverse range of structurally related DNA repair proteins. The superfamily is called the HhH-GPD family after its hallmark Helix-hairpin-helix and Gly/Pro rich loop followed by a conserved aspartate. This includes endonuclease III, EC:4.2.99.18 and MutY an A/G-specific adenine glycosylase, both have a C terminal 4Fe-4S cluster. The family also includes 8-oxoguanine DNA glycosylases. The methyl-CPG binding protein MBD4 also contains a related domain that is a thymine DNA glycosylase. The family also includes DNA-3-methyladenine glycosylase II EC:3.2.2.21 and other members of the AlkA family.


Pssm-ID: 425841 [Multi-domain]  Cd Length: 141  Bit Score: 143.96  E-value: 7.04e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514769207 126 LSLMLSSQTKDQVTAGAMQRLRAR-GLTVDSILQTDDATLGKLIYPVGFWRSKVKYIKQTSAILQQHYGGDIPASVAELV 204
Cdd:pfam00730   1 VSAILSQQTSDKAVNKITERLFEKfFPTPEDLADADEEELRELIRGLGFYRRKAKYLKELARILVEGYGGEVPLDEEELE 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1514769207 205 A-LPGVGPKMAHLAMAVAWG-TVSGIAVDTHVHRIANRLRWTkKATKSPEETRAALEEWLPR 264
Cdd:pfam00730  81 AlLKGVGRWTAEAVLIFALGrPDPLPVVDTHVRRVLKRLGLI-KEKPTPKEVERELEELWPP 141
PRK10702 PRK10702
endonuclease III; Provisional
 122-298 6.81e-24

endonuclease III; Provisional


Pssm-ID: 182661 [Multi-domain]  Cd Length: 211  Bit Score: 96.62  E-value: 6.81e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514769207 122 YQVLLSLMLSSQTKDQVTAGAMQRLRARGLTVDSILQTDDATLGKLIYPVGFWRSKVKYIKQTSAILQQHYGGDIPASVA 201
Cdd:PRK10702   30 FELLIAVLLSAQATDVSVNKATAKLYPVANTPAAMLELGVEGVKTYIKTIGLYNSKAENVIKTCRILLEQHNGEVPEDRA 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514769207 202 ELVALPGVGPKMAHLAMAVAWGTVSgIAVDTHVHRIANRLRWTkkATKSPEETRAALEEWLPRELWHEINGLLVGFGQQT 281
Cdd:PRK10702  110 ALEALPGVGRKTANVVLNTAFGWPT-IAVDTHIFRVCNRTQFA--PGKNVEQVEEKLLKVVPAEFKVDCHHWLILHGRYT 186

                         170
                  ....*....|....*..
gi 1514769207 282 CLPVHPRCHACLNQALC 298
Cdd:PRK10702  187 CIARKPRCGSCIIEDLC 203
HP0602 COG2231
3-Methyladenine DNA glycosylase, HhH-GPD/Endo3 superfamily [Replication, recombination and ...
 142-302 1.06e-20

3-Methyladenine DNA glycosylase, HhH-GPD/Endo3 superfamily [Replication, recombination and repair];


Pssm-ID: 441832 [Multi-domain]  Cd Length: 220  Bit Score: 88.36  E-value: 1.06e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514769207 142 AMQRLRARG-LTVDSILQTDDATLGKLIYPVGFWRSKVKYIKQTSAILQQHYGGDI------PASV--AELVALPGVGPK 212
Cdd:COG2231    50 AIANLKEAGlLDPEALAALDPEELAELIRPSGFYNQKAKRLKNLARWLVERYGGGLeklkalPTEElrEELLSLKGIGPE 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514769207 213 mahlamavawgTVSGIA----------VDTHVHRIANRLRWTKKaTKSPEETRAALEEWLPR--ELWHEINGLLVGFGQQ 280
Cdd:COG2231   130 -----------TADSILlyafnrpvfvVDAYTRRIFSRLGLIEE-DASYDELQRLFEENLPPdvALYNEFHALIVEHGKE 197

                         170       180
                  ....*....|....*....|..
gi 1514769207 281 TCLPVhPRCHACLNQALCPAAQ 302
Cdd:COG2231   198 YCKKK-PKCEECPLRDLCPYGG 218
HHH pfam00633
Helix-hairpin-helix motif; The helix-hairpin-helix DNA-binding motif is found to be duplicated ...
 191-215 3.41e-07

Helix-hairpin-helix motif; The helix-hairpin-helix DNA-binding motif is found to be duplicated in the central domain of RuvA. The HhH domain of DisA, a bacterial checkpoint control protein, is a DNA-binding domain.


Pssm-ID: 425789 [Multi-domain]  Cd Length: 30  Bit Score: 45.87  E-value: 3.41e-07
                          10        20
                  ....*....|....*....|....*
gi 1514769207 191 HYGGDIPASVAELVALPGVGPKMAH 215
Cdd:pfam00633   1 SLEGLIPASVEELLALPGVGPKTAE 25
AlkA COG0122
3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [Replication, recombination and ...
 152-261 4.26e-04

3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [Replication, recombination and repair];


Pssm-ID: 439892 [Multi-domain]  Cd Length: 255  Bit Score: 41.02  E-value: 4.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514769207 152 TVDSILQTDDATLGKLiypvGFWRSKVKYIKQTSAILQQH-------YGGDIPASVAELVALPGVGPKMAHLAMAVAWG- 223
Cdd:COG0122   129 TPEALAAASEEELRAC----GLSRRKARYLRALARAVADGeldlealAGLDDEEAIARLTALPGIGPWTAEMVLLFALGr 204

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1514769207 224 --TVSgiAVDTHVHRIANRLRWTKKATkSPEETRAALEEW 261
Cdd:COG0122   205 pdAFP--AGDLGLRRALGRLYGLGERP-TPKELRELAEPW 241
FES smart00525
iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); ...
 281-301 6.23e-04

iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3);


Pssm-ID: 197771 [Multi-domain]  Cd Length: 21  Bit Score: 36.37  E-value: 6.23e-04
                           10        20
                   ....*....|....*....|.
gi 1514769207  281 TCLPVHPRCHACLNQALCPAA 301
Cdd:smart00525   1 ICTARKPRCDECPLKDLCPAY 21
ogg TIGR00588
8-oxoguanine DNA-glycosylase (ogg); All proteins in this family for which functions are known ...
 177-272 8.40e-04

8-oxoguanine DNA-glycosylase (ogg); All proteins in this family for which functions are known are 8-oxo-guanaine DNA glycosylases that function in base excision repair. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). This family is distantly realted to the Nth-MutY superfamily. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 211589 [Multi-domain]  Cd Length: 310  Bit Score: 40.28  E-value: 8.40e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514769207 177 KVKYIKQTS----------AILQQHYGGDIPASVAELVALPGVGPKMAHLAMAVAWGTVSGIAVDTHVHRIANR---LRW 243
Cdd:TIGR00588 186 RARYIRETAralleeqggrAWLQQIRGASYEDAREALCELPGVGPKVADCICLMGLDKPQAVPVDVHVWRIANRdypWHP 265

                          90       100
                  ....*....|....*....|....*....
gi 1514769207 244 TKKATKSPEETRAALEEWLPRELWHEING 272
Cdd:TIGR00588 266 KTSRAKGPSPFARKELGNFFRSLWGPYAG 294
MutY COG1194
Adenine-specific DNA glycosylase, acts on AG and A-oxoG pairs [Replication, recombination and ...
 187-292 4.58e-03

Adenine-specific DNA glycosylase, acts on AG and A-oxoG pairs [Replication, recombination and repair];


Pssm-ID: 440807 [Multi-domain]  Cd Length: 350  Bit Score: 38.20  E-value: 4.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514769207 187 ILQQHYGGDIPASVAELVALPGVGPKMAHLAMAVAWGtVSGIAVDTHVHRIANRLRwtkkatkspeetraALEEWLP--- 263
Cdd:COG1194    94 QVVEEHGGVFPDTYEELLALPGIGPYTAAAIASIAFG-EPAPIVDGNVKRVLSRLF--------------AIEGPIGspa 158

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1514769207 264 --RELWHEINGLL----VG--------FGQQTCLPVHPRCHAC 292
Cdd:COG1194   159 akKELWALAEELLpperPGdfnqalmdLGATVCTPKKPKCLLC 201
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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