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2-oxoglutarate dehydrogenase complex component E1 isoform 1 precursor [Homo sapiens]
Protein Classification
2-oxoglutarate dehydrogenase family protein ( domain architecture ID 11426267 )
2-oxoglutarate dehydrogenase family protein, such as 2-oxoglutarate dehydrogenase subunit E1 that catalyzes the decarboxylation of 2-oxoglutarate and the formation of TPP-hydroxysuccinate
List of domain hits
Name
Accession
Description
Interval
E-value
SucA
COG0567 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes ...
49-1016
0e+00
2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes [Energy production and conversion]; 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 440333 [Multi-domain]
Cd Length: 935
Bit Score: 1322.77
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 49 FLSG TSSN Y V EE M Y CAW LE N P K SV HK SW DI FF RNTNAGAPPGTAYQ SP LPLSRGS LA AVAHAQSLVE A Q pn VDKLVEDHL 128
Cdd:COG0567 11 FLSG ANAA Y I EE L Y EQY LE D P D SV DP SW RA FF DGLPDVPGARDFAH SP IREEFRK LA KNGAGAAASA A A -- DPEAARKQV 88
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 129 A V QS LI R AY QI RGH HV A Q LDPLG ILD ---- AD LD ssvpadiisstdk LG FYGL D E S DLD K VF H lp T TTFI G GQE sa LP LR 204
Cdd:COG0567 89 R V LQ LI N AY RV RGH LF A K LDPLG LRE rpyv PE LD ------------- PA FYGL T E A DLD T VF N -- T GSLL G LET -- AT LR 151
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 205 EII RR L EMA YC QH IGVE F M F I N D L E QCQ WI RQKF E TP - GIMQ F TN EEK RTL L AR L VRSTR FE E FL QR K WSSE KRF G LEG C 283
Cdd:COG0567 152 EII AA L KET YC GS IGVE Y M H I S D P E EKR WI QERL E ST r NRPS F SA EEK KRI L EK L TAAEG FE K FL HT K YVGQ KRF S LEG G 231
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 284 E V LIPAL KTI I DKSS E N GV DYVIM GM P HRGRLNVL A N VIR K ELEQ IF CQ F DS K LEAADE GSGDVKYHLG m YHR ri NRV T D 363
Cdd:COG0567 232 E S LIPAL DEL I ERAG E L GV KEIVI GM A HRGRLNVL V N ILG K PPRD IF SE F EG K SAEDVL GSGDVKYHLG - FSS -- DVE T P 308
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 364 - RNIT LSL VA NPSHLE AAD PVV M G KTK A E Q FYC GDT EGK KV MS IL L HGDAAFAGQG I VYET FHL S D L PS Y T T H GT V H V V V 442
Cdd:COG0567 309 g GKVH LSL AF NPSHLE IVN PVV E G SVR A R Q DRR GDT DRD KV LP IL I HGDAAFAGQG V VYET LNM S Q L RG Y R T G GT I H I V I 388
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 443 NNQIGFTT D PR M ARSS P Y P TDVA RV V N APIFHVN S DDPEAV MY V CKV A AEW R ST F H KDVV V DLVCYRR N GHNE M DEP M FT 522
Cdd:COG0567 389 NNQIGFTT S PR D ARSS T Y C TDVA KM V Q APIFHVN G DDPEAV VF V ARL A LDY R QK F K KDVV I DLVCYRR H GHNE G DEP A FT 468
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 523 QPLMYK Q I R K QKPVLQK YA EL LV SQ GV VNQP E YE E EISK Y DKICE E A F ARS K d E KILHIKH WL DSP W PGFFT L d G QPRSM 602
Cdd:COG0567 469 QPLMYK K I K K HPTTREI YA DK LV AE GV ITAE E AD E MVDE Y RAALD E G F EVV K - E YKPNKAD WL EGD W SPYRR L - G EDWDD 546
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 603 SCP s TG LTEDI L THI G NVASSV P v E N F TI H GGLSR IL KT R GE M V - KNRTV DW AL AE YM A FG SLL K EG IHI RLSGQD VE RG 681
Cdd:COG0567 547 PVD - TG VPLEK L KEL G EKLTTL P - E G F KL H PKVEK IL ED R RK M A e GEKPL DW GM AE AL A YA SLL D EG YPV RLSGQD SG RG 624
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 682 TFSHRH H VLHDQ N v DKR T CI P M NHL WPN QA PYT V C NS S LSE YG VLGFE L G F A M A S PN A LV L WEAQFGDF H N T AQ CI IDQF 761
Cdd:COG0567 625 TFSHRH A VLHDQ K - TGE T YV P L NHL SEG QA RFE V Y NS L LSE EA VLGFE Y G Y A L A E PN T LV I WEAQFGDF A N G AQ VV IDQF 703
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 762 I CP G QA KW V R QN G I V L LLPHG M EG M GPEHSSAR P ERFLQ M C ND D pdvlpdlkeanfdinqlydc N WV V V N CS TP GNF FH V 841
Cdd:COG0567 704 I SS G ES KW G R LS G L V M LLPHG Y EG Q GPEHSSAR L ERFLQ L C AE D -------------------- N MQ V C N PT TP AQY FH L 763
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 842 LRRQ ILL PFRKPLI IF TPKSLLRH PE A R SS FD E MLP G t H FQ R VI PEDGPA aq N P EN VKR LLF C T GKVYYDL T --- RER KA 918
Cdd:COG0567 764 LRRQ MKR PFRKPLI VM TPKSLLRH KL A V SS LE E LAE G - S FQ E VI DDTDEL -- D P KK VKR VVL C S GKVYYDL L eer RER GR 840
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 919 R D mvgq VAI T RIEQL S PFP FDL L LK E VQ KYPNA - E LA WCQEE H KN Q G YYDYVKP RL RTTISRAKPVW YAGR DPA A A PATG 997
Cdd:COG0567 841 D D ---- VAI V RIEQL Y PFP EEE L AA E LA KYPNA k E VV WCQEE P KN M G AWYFIQH RL EEVLPKGQRLR YAGR PAS A S PATG 916
970
....*....|....*....
gi 51873036 998 NKKT H LT E LQR L LDT A FDL 1016
Cdd:COG0567 917 YMSV H KA E QKA L VEE A LGI 935
Name
Accession
Description
Interval
E-value
SucA
COG0567 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes ...
49-1016
0e+00
2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes [Energy production and conversion]; 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 440333 [Multi-domain]
Cd Length: 935
Bit Score: 1322.77
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 49 FLSG TSSN Y V EE M Y CAW LE N P K SV HK SW DI FF RNTNAGAPPGTAYQ SP LPLSRGS LA AVAHAQSLVE A Q pn VDKLVEDHL 128
Cdd:COG0567 11 FLSG ANAA Y I EE L Y EQY LE D P D SV DP SW RA FF DGLPDVPGARDFAH SP IREEFRK LA KNGAGAAASA A A -- DPEAARKQV 88
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 129 A V QS LI R AY QI RGH HV A Q LDPLG ILD ---- AD LD ssvpadiisstdk LG FYGL D E S DLD K VF H lp T TTFI G GQE sa LP LR 204
Cdd:COG0567 89 R V LQ LI N AY RV RGH LF A K LDPLG LRE rpyv PE LD ------------- PA FYGL T E A DLD T VF N -- T GSLL G LET -- AT LR 151
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 205 EII RR L EMA YC QH IGVE F M F I N D L E QCQ WI RQKF E TP - GIMQ F TN EEK RTL L AR L VRSTR FE E FL QR K WSSE KRF G LEG C 283
Cdd:COG0567 152 EII AA L KET YC GS IGVE Y M H I S D P E EKR WI QERL E ST r NRPS F SA EEK KRI L EK L TAAEG FE K FL HT K YVGQ KRF S LEG G 231
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 284 E V LIPAL KTI I DKSS E N GV DYVIM GM P HRGRLNVL A N VIR K ELEQ IF CQ F DS K LEAADE GSGDVKYHLG m YHR ri NRV T D 363
Cdd:COG0567 232 E S LIPAL DEL I ERAG E L GV KEIVI GM A HRGRLNVL V N ILG K PPRD IF SE F EG K SAEDVL GSGDVKYHLG - FSS -- DVE T P 308
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 364 - RNIT LSL VA NPSHLE AAD PVV M G KTK A E Q FYC GDT EGK KV MS IL L HGDAAFAGQG I VYET FHL S D L PS Y T T H GT V H V V V 442
Cdd:COG0567 309 g GKVH LSL AF NPSHLE IVN PVV E G SVR A R Q DRR GDT DRD KV LP IL I HGDAAFAGQG V VYET LNM S Q L RG Y R T G GT I H I V I 388
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 443 NNQIGFTT D PR M ARSS P Y P TDVA RV V N APIFHVN S DDPEAV MY V CKV A AEW R ST F H KDVV V DLVCYRR N GHNE M DEP M FT 522
Cdd:COG0567 389 NNQIGFTT S PR D ARSS T Y C TDVA KM V Q APIFHVN G DDPEAV VF V ARL A LDY R QK F K KDVV I DLVCYRR H GHNE G DEP A FT 468
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 523 QPLMYK Q I R K QKPVLQK YA EL LV SQ GV VNQP E YE E EISK Y DKICE E A F ARS K d E KILHIKH WL DSP W PGFFT L d G QPRSM 602
Cdd:COG0567 469 QPLMYK K I K K HPTTREI YA DK LV AE GV ITAE E AD E MVDE Y RAALD E G F EVV K - E YKPNKAD WL EGD W SPYRR L - G EDWDD 546
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 603 SCP s TG LTEDI L THI G NVASSV P v E N F TI H GGLSR IL KT R GE M V - KNRTV DW AL AE YM A FG SLL K EG IHI RLSGQD VE RG 681
Cdd:COG0567 547 PVD - TG VPLEK L KEL G EKLTTL P - E G F KL H PKVEK IL ED R RK M A e GEKPL DW GM AE AL A YA SLL D EG YPV RLSGQD SG RG 624
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 682 TFSHRH H VLHDQ N v DKR T CI P M NHL WPN QA PYT V C NS S LSE YG VLGFE L G F A M A S PN A LV L WEAQFGDF H N T AQ CI IDQF 761
Cdd:COG0567 625 TFSHRH A VLHDQ K - TGE T YV P L NHL SEG QA RFE V Y NS L LSE EA VLGFE Y G Y A L A E PN T LV I WEAQFGDF A N G AQ VV IDQF 703
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 762 I CP G QA KW V R QN G I V L LLPHG M EG M GPEHSSAR P ERFLQ M C ND D pdvlpdlkeanfdinqlydc N WV V V N CS TP GNF FH V 841
Cdd:COG0567 704 I SS G ES KW G R LS G L V M LLPHG Y EG Q GPEHSSAR L ERFLQ L C AE D -------------------- N MQ V C N PT TP AQY FH L 763
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 842 LRRQ ILL PFRKPLI IF TPKSLLRH PE A R SS FD E MLP G t H FQ R VI PEDGPA aq N P EN VKR LLF C T GKVYYDL T --- RER KA 918
Cdd:COG0567 764 LRRQ MKR PFRKPLI VM TPKSLLRH KL A V SS LE E LAE G - S FQ E VI DDTDEL -- D P KK VKR VVL C S GKVYYDL L eer RER GR 840
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 919 R D mvgq VAI T RIEQL S PFP FDL L LK E VQ KYPNA - E LA WCQEE H KN Q G YYDYVKP RL RTTISRAKPVW YAGR DPA A A PATG 997
Cdd:COG0567 841 D D ---- VAI V RIEQL Y PFP EEE L AA E LA KYPNA k E VV WCQEE P KN M G AWYFIQH RL EEVLPKGQRLR YAGR PAS A S PATG 916
970
....*....|....*....
gi 51873036 998 NKKT H LT E LQR L LDT A FDL 1016
Cdd:COG0567 917 YMSV H KA E QKA L VEE A LGI 935
sucA
PRK09404 2-oxoglutarate dehydrogenase E1 component; Reviewed
49-1015
0e+00
2-oxoglutarate dehydrogenase E1 component; Reviewed
Pssm-ID: 236499 [Multi-domain]
Cd Length: 924
Bit Score: 1275.05
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 49 FL S G TSSN Y V EE M Y CAW L EN P K SV HKS W DI FF RNTNAG AP PGTA yqsplplsrgs L A AVAHAQS L VEAQPNVDKLVEDHL 128
Cdd:PRK09404 13 FL F G ANAA Y I EE L Y EQY L KD P D SV DEE W RA FF DGLPGV AP DVAH ----------- S A VRESFRR L AKPARVSSAVSDPQV 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 129 A V QS LI R AY QI RGH HV A Q LDPLG IL ---- DAD LD ssvpadiisstdk LG FYGL D E S DLD KV F H lp T TTFIG G Q E S A l P LR 204
Cdd:PRK09404 82 K V LQ LI N AY RF RGH LA A N LDPLG LW krpd VPE LD ------------- PA FYGL T E A DLD RT F N -- T GSLAL G K E T A - T LR 145
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 205 EII RR L EMA YC QH IGVE F M F I N D L E QCQ W IR Q KF E TPGI m Q F TN EEK RTL L A RL VRSTR FE E FL QR K WSSE KRF G LEG C E 284
Cdd:PRK09404 146 EII EA L KKT YC GS IGVE Y M H I S D P E ERR W LQ Q RI E SGRP - S F SA EEK KAI L E RL TAAEG FE R FL HT K FVGQ KRF S LEG G E 224
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 285 V LIP A L KT II DKSSEN GV DYVIM GM P HRGRLNVL A NV IR K ELEQI F CQ F DS K LEAAD - E GSGDVKYHLG m YHR ri N R V TD 363
Cdd:PRK09404 225 S LIP M L DE II RRAGKL GV KEIVI GM A HRGRLNVL V NV LG K PPRDL F AE F EG K HGPDE v L GSGDVKYHLG - FSS -- D R E TD 301
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 364 - RNIT LSL VA NPSHLE AAD PVV M G KTK A E Q FYC GD - TEG KKV MS IL L HGDAAFAGQG I V Y ET FH LS D L PS Y T T H GT V H V V 441
Cdd:PRK09404 302 g GEVH LSL AF NPSHLE IVN PVV E G SVR A R Q DRR GD g QDR KKV LP IL I HGDAAFAGQG V V A ET LN LS Q L RG Y R T G GT I H I V 381
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 442 V NNQIGFTT D P RMA RS S PY P TDVA RV V N APIFHVN S DDPEAV MYVCKV A A E W R ST F H KDVV V DLVCYRR N GHNE M DEP M F 521
Cdd:PRK09404 382 I NNQIGFTT S P PDD RS T PY C TDVA KM V Q APIFHVN G DDPEAV VFATRL A L E Y R QK F K KDVV I DLVCYRR H GHNE G DEP S F 461
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 522 TQPLMYK Q I R K QKPVLQK YA EL LV SQ GV VNQP E YE E EISK Y DKICEEA F ARS K DEK ilh IKH WL DSP W PGFFTLDGQPR s 601
Cdd:PRK09404 462 TQPLMYK K I K K HPTTREL YA DK LV AE GV ITEE E AD E MVNE Y RDALDAG F EVV K EWR --- PAD WL AGD W SPYLGHEWDDP - 537
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 602 msc PS TG LTEDI L THIGNVASS VP v E N F TI H GGLSR IL KT R G EM VK - NRTV DW AL AE YM AF G SLL K EG IHI RLSGQD VE R 680
Cdd:PRK09404 538 --- VD TG VPLER L KELAEKLTT VP - E G F KV H PKVKK IL ED R R EM AE g EKPI DW GM AE AL AF A SLL D EG YPV RLSGQD SG R 613
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 681 GTFSHRH H VLHDQ N v DKR T C IP M NHL WPN QA PYT V CN S S LSE YG VLGFE L G FAM A S PN A LV L WEAQFGDF H N T AQ CI IDQ 760
Cdd:PRK09404 614 GTFSHRH A VLHDQ K - TGE T Y IP L NHL SEG QA SFE V YD S P LSE EA VLGFE Y G YST A E PN T LV I WEAQFGDF A N G AQ VV IDQ 692
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 761 FI CP G QA KW V R QN G I V L LLPHG M EG M GPEHSSAR P ERFLQ M C ND D pdvlpdlkeanfdinqlydc N WV V V N CS TP GNF FH 840
Cdd:PRK09404 693 FI SS G EQ KW G R LS G L V M LLPHG Y EG Q GPEHSSAR L ERFLQ L C AE D -------------------- N MQ V C N PT TP AQY FH 752
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 841 V LRRQ I L L PFRKPL IIF TPKSLLRHP E A R SS FD E MLP G T h FQ R VI PE dg PAAQN P EN VKR LLF C T GKVYYDL TRE R KA R D 920
Cdd:PRK09404 753 L LRRQ A L R PFRKPL VVM TPKSLLRHP L A V SS LE E LAE G S - FQ P VI GD -- IDELD P KK VKR VVL C S GKVYYDL LEA R RK R G 829
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 921 m VGQ VAI T RIEQL S PFP FDL L LK E VQ KYPNA - E LA WCQEE H KNQG YYDYVKPR L RTTISRAKPVW YAGR DPA A A PA T G NK 999
Cdd:PRK09404 830 - IDD VAI V RIEQL Y PFP HEE L AA E LA KYPNA k E VV WCQEE P KNQG AWYFIQHH L EEVLPEGQKLR YAGR PAS A S PA V G YM 908
970
....*....|....*.
gi 51873036 1000 KT H LTELQR L LDT A FD 1015
Cdd:PRK09404 909 SL H KKQQEA L VED A LG 924
2oxo_dh_E1
TIGR00239 2-oxoglutarate dehydrogenase, E1 component; The 2-oxoglutarate dehydrogenase complex consists ...
49-1014
0e+00
2-oxoglutarate dehydrogenase, E1 component; The 2-oxoglutarate dehydrogenase complex consists of this thiamine pyrophosphate-binding subunit (E1), dihydrolipoamide succinyltransferase (E2), and lipoamide dehydrogenase (E3). The E1 ortholog from Corynebacterium glutamicum is unusual in having an N-terminal extension that resembles the dihydrolipoamide succinyltransferase (E2) component of 2-oxoglutarate dehydrogenase. [Energy metabolism, TCA cycle]
Pssm-ID: 161785 [Multi-domain]
Cd Length: 929
Bit Score: 992.84
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 49 F LSG TSSN Y V EE M Y CAW L EN P K SV HK SW DIF F RNTNAGA P PGTAYQ SP LPLSRGS LA AV A HAQ S LVEAQ P nv D KL V EDHL 128
Cdd:TIGR00239 1 Y LSG ANQS Y I EE L Y EDY L TD P D SV DA SW RST F DQLPGPG P APDQFH SP TRSYFRR LA KD A SRG S VTISD P -- D TN V SQVK 78
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 129 AV Q s LIRAY QI RGH HV A Q LDPLG ILDA D ldss VPADI isstd K L G FYGL D E S DL DKV F HLPTTTFIGGQESA L PLR E IIR 208
Cdd:TIGR00239 79 VL Q - LIRAY RF RGH LH A N LDPLG LKQQ D ---- KVPEL ----- D L S FYGL T E A DL QET F NIGSFVSGKDATMK L SNL E LLQ 148
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 209 R L EMA YC QH IG V E F M F I NDL E QCQ W IR Q KF E TPGIM QF TN EEK RTL L A RL VRSTR FE E FL QR K WSSE KRF G LEG CEV L I P 288
Cdd:TIGR00239 149 A L KQT YC GS IG A E Y M H I TST E EKR W LQ Q RI E SGERA QF NS EEK KRF L S RL TAAEG FE R FL GA K FPGA KRF S LEG LDA L V P 228
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 289 A LK T II DK S SEN G VDY V IM GM P HRGRLNVL A NV IR K EL E Q IF CQ F DS K LEAAD - E G S GDVKYH L G MYHRRIN r VTDRNIT 367
Cdd:TIGR00239 229 M LK E II RH S VNS G TRD V VL GM A HRGRLNVL V NV LG K PP E D IF SE F AG K HKSHL p D G T GDVKYH M G RFSSDFT - TDGKLVH 307
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 368 L S L VA NPSHLE AAD PVV M G K T K A EQFYCG D - T E GK KV MS IL L HGDAAFAGQG I V Y ET FHL S D L PS Y TTH GT V H VVV NNQI 446
Cdd:TIGR00239 308 L A L AF NPSHLE IVS PVV I G S T R A RLDRLN D s P E ST KV LA IL I HGDAAFAGQG V V Q ET LNM S K L RG Y SVG GT I H III NNQI 387
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 447 GFTT D P RM ARS S PY PT D V A RVVN APIFHVN S DDPEAV MYVCKV A A E W R S TF HK DV VV DLV C YRR N GHNE M DEP MF TQPLM 526
Cdd:TIGR00239 388 GFTT N P LD ARS T PY CS D L A KMIQ APIFHVN A DDPEAV AFATRL A V E Y R N TF KR DV FI DLV G YRR H GHNE A DEP SA TQPLM 467
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 527 Y KQ I R K QKPVLQK YA EL LVS Q GV VN qpey EE EISKYDKICEE A FARSKD e KILHIKHWLDSPWPGFFT L D g QPRSMSC P S 606
Cdd:TIGR00239 468 Y QK I K K HPTPRKV YA DK LVS E GV AT ---- EE DVTEMVNLYRD A LEAADC - VVPSWREMNTASFTWSPE L N - HEWDEEY P N 541
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 607 T g LTEDI L THIGNVA S S VP v E NFTI H GGLSR I LKT R GEMVK -- NRTV DW AL AE YM AF GS L LKE GI HI RLSG Q D V ERGTF S 684
Cdd:TIGR00239 542 K - VEMKR L QELAKRI S E VP - E GVEM H SRVAK I YFD R TKAMA ag EKLF DW GG AE NL AF AT L VDD GI PV RLSG E D S ERGTF F 619
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 685 H RH H VLHDQ N v DKR T CI P MN HL WPN Q APYT V C NS S LSE YG VLGFE L G F A MA SP NA LV L WEAQFGDF H N T AQ CI IDQFI CP 764
Cdd:TIGR00239 620 Q RH A VLHDQ S - NGS T YT P LQ HL HNG Q GAFR V W NS V LSE ES VLGFE Y G Y A TT SP RT LV I WEAQFGDF A N G AQ VV IDQFI SS 698
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 765 G QA KW VRQN G I V L LLPHG M EG M GPEHSS A R P ERFLQ MCNDD pdvlpdlkeanfdinqlydc N WV V VNCS TP GNF FH V LRR 844
Cdd:TIGR00239 699 G EQ KW GQMS G L V M LLPHG Y EG Q GPEHSS G R L ERFLQ LAAEQ -------------------- N MQ V CVPT TP AQV FH I LRR 758
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 845 Q I L LPF R K PL IIFT PKSLLRHP E A R SS FD E MLP GT h FQ R VI P -- E DGPAAQN PE N VKRL LF C T GKVYYDL t R E RKARDMV 922
Cdd:TIGR00239 759 Q A L RGM R R PL VVMS PKSLLRHP L A V SS LE E LAE GT - FQ P VI G ei E ESGLSLD PE G VKRL VL C S GKVYYDL - H E QRRKNGQ 836
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 923 GQ VAI T RIEQL S PFP FDLLLKEV Q K YPN - A E LA WCQEE HK N Q G YYD Y VK P R LR TT I SRAKP V W YAGR DPA A A PA T G NKKT 1001
Cdd:TIGR00239 837 KD VAI V RIEQL Y PFP HKAVKEVL Q Q YPN l K E IV WCQEE PL N M G AWY Y SQ P H LR EV I PEGVS V R YAGR PAS A S PA V G YMSL 916
970
....*....|...
gi 51873036 1002 H LTEL Q R LL DT A F 1014
Cdd:TIGR00239 917 H QKQQ Q D LL ND A L 929
TPP_E1_OGDC_like
cd02016 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed ...
264-527
1.25e-179
Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of 2-oxoglutarate to succinyl-CoA and carbon dioxide, a key reaction of the tricarboxylic acid cycle.
Pssm-ID: 238974 [Multi-domain]
Cd Length: 265
Bit Score: 522.47
E-value: 1.25e-179
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 264 FE E FL QR K WSSE KRFGLEG C E V LIPAL KTI ID KSS E N GV DY V IM GM P HRGRLNVLANV IR K E LEQIF CQ F DS K L E AAD -- 341
Cdd:cd02016 1 FE Q FL AT K FPGQ KRFGLEG A E S LIPAL DEL ID RAA E L GV EE V VI GM A HRGRLNVLANV LG K P LEQIF SE F EG K S E FPE dd 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 342 EGSGDVKYHLG MYHR R INRV t DRNIT LSL VA NPSHLEA AD PVVMGKT K A E Q F Y C GD T E GK KV MS IL L HGDAAFAGQG I VY 421
Cdd:cd02016 81 EGSGDVKYHLG YSSD R KTPS - GKKVH LSL AP NPSHLEA VN PVVMGKT R A K Q D Y R GD G E RD KV LP IL I HGDAAFAGQG V VY 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 422 ET FH LS D LP S YTT H GT V H V VVNNQIGFTTDPR MA RSSPY P TDVA RVVN APIFHVN S DDPEAV MYVCKV A A E W R ST F H KDV 501
Cdd:cd02016 160 ET LN LS N LP G YTT G GT I H I VVNNQIGFTTDPR DS RSSPY C TDVA KMIG APIFHVN G DDPEAV VRATRL A L E Y R QK F K KDV 239
250 260
....*....|....*....|....*.
gi 51873036 502 V V DLVCYRR N GHNE M DEP M FTQPLMY 527
Cdd:cd02016 240 V I DLVCYRR H GHNE L DEP S FTQPLMY 265
E1_dh
pfam00676 Dehydrogenase E1 component; This family uses thiamine pyrophosphate as a cofactor. This family ...
256-582
7.07e-112
Dehydrogenase E1 component; This family uses thiamine pyrophosphate as a cofactor. This family includes pyruvate dehydrogenase, 2-oxoglutarate dehydrogenase and 2-oxoisovalerate dehydrogenase.
Pssm-ID: 395548 [Multi-domain]
Cd Length: 300
Bit Score: 348.16
E-value: 7.07e-112
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 256 A R LVRST R F E EFLQRKWSSEKRF G LEGCEVLIP A LKTI I DKSS E N G v DY V I M G mp H R GRL N V LA NVIR ke LE Q IF CQFDS 335
Cdd:pfam00676 1 R R MMTLR R M E DARDALYKRQGIR G FYHLYAGQE A AQVG I AAAL E P G - DY I I P G -- Y R DHG N L LA RGLS -- LE E IF AELYG 75
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 336 KLE aad E G S G DVKY hl G M Y HRRI NR VTDR N IT L SLVAN pshl EA A DPVVMG K T kaeqfycgdt E GKK VMS I L L H GD A A f A 415
Cdd:pfam00676 76 RVA --- K G K G GSMH -- G Y Y GAKG NR FYGG N GI L GAQVP ---- LG A GIALAA K Y ---------- R GKK EVA I T L Y GD G A - A 135
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 416 G QG IVY E TFHLSD L PSYTT hgt VH V VV NNQ I G FT T DPRM A RS S PYPT D V AR VVNA P IF HV NSD DP E AV MYVC K V AAE WRS 495
Cdd:pfam00676 136 N QG DFF E GLNFAA L WKLPV --- IF V CE NNQ Y G IS T PAER A SA S TTYA D R AR GYGI P GL HV DGM DP L AV YQAS K F AAE RAR 212
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 496 T FHKDVVVD LV C YR RN GH NEM D E P MFTQ - PLM Y KQI RK Q K PVL Q KYA E L LVS Q GV VNQP E YEEEISKYD K IC EEAF ARSK 574
Cdd:pfam00676 213 T GKGPFLIE LV T YR YG GH SMS D D P STYR t RDE Y EEV RK K K DPI Q RFK E H LVS K GV WSEE E LKAIEKEVR K EV EEAF KKAE 292
....*...
gi 51873036 575 DEKIL H IK 582
Cdd:pfam00676 293 SAPEP H PE 300
Transket_pyr
smart00861 Transketolase, pyrimidine binding domain; Transketolase (TK) catalyzes the reversible transfer ...
717-864
4.19e-22
Transketolase, pyrimidine binding domain; Transketolase (TK) catalyzes the reversible transfer of a two-carbon ketol unit from xylulose 5-phosphate to an aldose receptor, such as ribose 5-phosphate, to form sedoheptulose 7-phosphate and glyceraldehyde 3- phosphate. This enzyme, together with transaldolase, provides a link between the glycolytic and pentose-phosphate pathways. TK requires thiamine pyrophosphate as a cofactor. In most sources where TK has been purified, it is a homodimer of approximately 70 Kd subunits. TK sequences from a variety of eukaryotic and prokaryotic sources show that the enzyme has been evolutionarily conserved. In the peroxisomes of methylotrophic yeast Hansenula polymorpha, there is a highly related enzyme, dihydroxy-acetone synthase (DHAS) (also known as formaldehyde transketolase), which exhibits a very unusual specificity by including formaldehyde amongst its substrates.
Pssm-ID: 214865 [Multi-domain]
Cd Length: 136
Bit Score: 92.93
E-value: 4.19e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 717 NSSLS E YGVL GF EL G F A MA spn A L VLWEAQ F GD F HNT A QCI I DQFIC pgqak WVRQNGIVLLLPH G ME G M - GP E H S S ARP 795
Cdd:smart00861 19 DTGIA E QAMV GF AA G L A LH --- G L RPVVEI F FT F FDR A KDQ I RSAGA ----- SGNVPVVFRHDGG G GV G E d GP T H H S IED 90
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 796 E - RFLQM cnddpdvlpdlkeanfdinqlyd CNWV VV NC S T P GNFFHV LR RQ I LLP f RKPL I IFTP KSL L R 864
Cdd:smart00861 91 E a LLRAI ----------------------- PGLK VV AP S D P AEAKGL LR AA I RDD - GPVV I RLER KSL Y R 136
Name
Accession
Description
Interval
E-value
SucA
COG0567 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes ...
49-1016
0e+00
2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes [Energy production and conversion]; 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 440333 [Multi-domain]
Cd Length: 935
Bit Score: 1322.77
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 49 FLSG TSSN Y V EE M Y CAW LE N P K SV HK SW DI FF RNTNAGAPPGTAYQ SP LPLSRGS LA AVAHAQSLVE A Q pn VDKLVEDHL 128
Cdd:COG0567 11 FLSG ANAA Y I EE L Y EQY LE D P D SV DP SW RA FF DGLPDVPGARDFAH SP IREEFRK LA KNGAGAAASA A A -- DPEAARKQV 88
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 129 A V QS LI R AY QI RGH HV A Q LDPLG ILD ---- AD LD ssvpadiisstdk LG FYGL D E S DLD K VF H lp T TTFI G GQE sa LP LR 204
Cdd:COG0567 89 R V LQ LI N AY RV RGH LF A K LDPLG LRE rpyv PE LD ------------- PA FYGL T E A DLD T VF N -- T GSLL G LET -- AT LR 151
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 205 EII RR L EMA YC QH IGVE F M F I N D L E QCQ WI RQKF E TP - GIMQ F TN EEK RTL L AR L VRSTR FE E FL QR K WSSE KRF G LEG C 283
Cdd:COG0567 152 EII AA L KET YC GS IGVE Y M H I S D P E EKR WI QERL E ST r NRPS F SA EEK KRI L EK L TAAEG FE K FL HT K YVGQ KRF S LEG G 231
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 284 E V LIPAL KTI I DKSS E N GV DYVIM GM P HRGRLNVL A N VIR K ELEQ IF CQ F DS K LEAADE GSGDVKYHLG m YHR ri NRV T D 363
Cdd:COG0567 232 E S LIPAL DEL I ERAG E L GV KEIVI GM A HRGRLNVL V N ILG K PPRD IF SE F EG K SAEDVL GSGDVKYHLG - FSS -- DVE T P 308
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 364 - RNIT LSL VA NPSHLE AAD PVV M G KTK A E Q FYC GDT EGK KV MS IL L HGDAAFAGQG I VYET FHL S D L PS Y T T H GT V H V V V 442
Cdd:COG0567 309 g GKVH LSL AF NPSHLE IVN PVV E G SVR A R Q DRR GDT DRD KV LP IL I HGDAAFAGQG V VYET LNM S Q L RG Y R T G GT I H I V I 388
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 443 NNQIGFTT D PR M ARSS P Y P TDVA RV V N APIFHVN S DDPEAV MY V CKV A AEW R ST F H KDVV V DLVCYRR N GHNE M DEP M FT 522
Cdd:COG0567 389 NNQIGFTT S PR D ARSS T Y C TDVA KM V Q APIFHVN G DDPEAV VF V ARL A LDY R QK F K KDVV I DLVCYRR H GHNE G DEP A FT 468
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 523 QPLMYK Q I R K QKPVLQK YA EL LV SQ GV VNQP E YE E EISK Y DKICE E A F ARS K d E KILHIKH WL DSP W PGFFT L d G QPRSM 602
Cdd:COG0567 469 QPLMYK K I K K HPTTREI YA DK LV AE GV ITAE E AD E MVDE Y RAALD E G F EVV K - E YKPNKAD WL EGD W SPYRR L - G EDWDD 546
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 603 SCP s TG LTEDI L THI G NVASSV P v E N F TI H GGLSR IL KT R GE M V - KNRTV DW AL AE YM A FG SLL K EG IHI RLSGQD VE RG 681
Cdd:COG0567 547 PVD - TG VPLEK L KEL G EKLTTL P - E G F KL H PKVEK IL ED R RK M A e GEKPL DW GM AE AL A YA SLL D EG YPV RLSGQD SG RG 624
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 682 TFSHRH H VLHDQ N v DKR T CI P M NHL WPN QA PYT V C NS S LSE YG VLGFE L G F A M A S PN A LV L WEAQFGDF H N T AQ CI IDQF 761
Cdd:COG0567 625 TFSHRH A VLHDQ K - TGE T YV P L NHL SEG QA RFE V Y NS L LSE EA VLGFE Y G Y A L A E PN T LV I WEAQFGDF A N G AQ VV IDQF 703
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 762 I CP G QA KW V R QN G I V L LLPHG M EG M GPEHSSAR P ERFLQ M C ND D pdvlpdlkeanfdinqlydc N WV V V N CS TP GNF FH V 841
Cdd:COG0567 704 I SS G ES KW G R LS G L V M LLPHG Y EG Q GPEHSSAR L ERFLQ L C AE D -------------------- N MQ V C N PT TP AQY FH L 763
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 842 LRRQ ILL PFRKPLI IF TPKSLLRH PE A R SS FD E MLP G t H FQ R VI PEDGPA aq N P EN VKR LLF C T GKVYYDL T --- RER KA 918
Cdd:COG0567 764 LRRQ MKR PFRKPLI VM TPKSLLRH KL A V SS LE E LAE G - S FQ E VI DDTDEL -- D P KK VKR VVL C S GKVYYDL L eer RER GR 840
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 919 R D mvgq VAI T RIEQL S PFP FDL L LK E VQ KYPNA - E LA WCQEE H KN Q G YYDYVKP RL RTTISRAKPVW YAGR DPA A A PATG 997
Cdd:COG0567 841 D D ---- VAI V RIEQL Y PFP EEE L AA E LA KYPNA k E VV WCQEE P KN M G AWYFIQH RL EEVLPKGQRLR YAGR PAS A S PATG 916
970
....*....|....*....
gi 51873036 998 NKKT H LT E LQR L LDT A FDL 1016
Cdd:COG0567 917 YMSV H KA E QKA L VEE A LGI 935
sucA
PRK09404 2-oxoglutarate dehydrogenase E1 component; Reviewed
49-1015
0e+00
2-oxoglutarate dehydrogenase E1 component; Reviewed
Pssm-ID: 236499 [Multi-domain]
Cd Length: 924
Bit Score: 1275.05
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 49 FL S G TSSN Y V EE M Y CAW L EN P K SV HKS W DI FF RNTNAG AP PGTA yqsplplsrgs L A AVAHAQS L VEAQPNVDKLVEDHL 128
Cdd:PRK09404 13 FL F G ANAA Y I EE L Y EQY L KD P D SV DEE W RA FF DGLPGV AP DVAH ----------- S A VRESFRR L AKPARVSSAVSDPQV 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 129 A V QS LI R AY QI RGH HV A Q LDPLG IL ---- DAD LD ssvpadiisstdk LG FYGL D E S DLD KV F H lp T TTFIG G Q E S A l P LR 204
Cdd:PRK09404 82 K V LQ LI N AY RF RGH LA A N LDPLG LW krpd VPE LD ------------- PA FYGL T E A DLD RT F N -- T GSLAL G K E T A - T LR 145
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 205 EII RR L EMA YC QH IGVE F M F I N D L E QCQ W IR Q KF E TPGI m Q F TN EEK RTL L A RL VRSTR FE E FL QR K WSSE KRF G LEG C E 284
Cdd:PRK09404 146 EII EA L KKT YC GS IGVE Y M H I S D P E ERR W LQ Q RI E SGRP - S F SA EEK KAI L E RL TAAEG FE R FL HT K FVGQ KRF S LEG G E 224
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 285 V LIP A L KT II DKSSEN GV DYVIM GM P HRGRLNVL A NV IR K ELEQI F CQ F DS K LEAAD - E GSGDVKYHLG m YHR ri N R V TD 363
Cdd:PRK09404 225 S LIP M L DE II RRAGKL GV KEIVI GM A HRGRLNVL V NV LG K PPRDL F AE F EG K HGPDE v L GSGDVKYHLG - FSS -- D R E TD 301
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 364 - RNIT LSL VA NPSHLE AAD PVV M G KTK A E Q FYC GD - TEG KKV MS IL L HGDAAFAGQG I V Y ET FH LS D L PS Y T T H GT V H V V 441
Cdd:PRK09404 302 g GEVH LSL AF NPSHLE IVN PVV E G SVR A R Q DRR GD g QDR KKV LP IL I HGDAAFAGQG V V A ET LN LS Q L RG Y R T G GT I H I V 381
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 442 V NNQIGFTT D P RMA RS S PY P TDVA RV V N APIFHVN S DDPEAV MYVCKV A A E W R ST F H KDVV V DLVCYRR N GHNE M DEP M F 521
Cdd:PRK09404 382 I NNQIGFTT S P PDD RS T PY C TDVA KM V Q APIFHVN G DDPEAV VFATRL A L E Y R QK F K KDVV I DLVCYRR H GHNE G DEP S F 461
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 522 TQPLMYK Q I R K QKPVLQK YA EL LV SQ GV VNQP E YE E EISK Y DKICEEA F ARS K DEK ilh IKH WL DSP W PGFFTLDGQPR s 601
Cdd:PRK09404 462 TQPLMYK K I K K HPTTREL YA DK LV AE GV ITEE E AD E MVNE Y RDALDAG F EVV K EWR --- PAD WL AGD W SPYLGHEWDDP - 537
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 602 msc PS TG LTEDI L THIGNVASS VP v E N F TI H GGLSR IL KT R G EM VK - NRTV DW AL AE YM AF G SLL K EG IHI RLSGQD VE R 680
Cdd:PRK09404 538 --- VD TG VPLER L KELAEKLTT VP - E G F KV H PKVKK IL ED R R EM AE g EKPI DW GM AE AL AF A SLL D EG YPV RLSGQD SG R 613
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 681 GTFSHRH H VLHDQ N v DKR T C IP M NHL WPN QA PYT V CN S S LSE YG VLGFE L G FAM A S PN A LV L WEAQFGDF H N T AQ CI IDQ 760
Cdd:PRK09404 614 GTFSHRH A VLHDQ K - TGE T Y IP L NHL SEG QA SFE V YD S P LSE EA VLGFE Y G YST A E PN T LV I WEAQFGDF A N G AQ VV IDQ 692
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 761 FI CP G QA KW V R QN G I V L LLPHG M EG M GPEHSSAR P ERFLQ M C ND D pdvlpdlkeanfdinqlydc N WV V V N CS TP GNF FH 840
Cdd:PRK09404 693 FI SS G EQ KW G R LS G L V M LLPHG Y EG Q GPEHSSAR L ERFLQ L C AE D -------------------- N MQ V C N PT TP AQY FH 752
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 841 V LRRQ I L L PFRKPL IIF TPKSLLRHP E A R SS FD E MLP G T h FQ R VI PE dg PAAQN P EN VKR LLF C T GKVYYDL TRE R KA R D 920
Cdd:PRK09404 753 L LRRQ A L R PFRKPL VVM TPKSLLRHP L A V SS LE E LAE G S - FQ P VI GD -- IDELD P KK VKR VVL C S GKVYYDL LEA R RK R G 829
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 921 m VGQ VAI T RIEQL S PFP FDL L LK E VQ KYPNA - E LA WCQEE H KNQG YYDYVKPR L RTTISRAKPVW YAGR DPA A A PA T G NK 999
Cdd:PRK09404 830 - IDD VAI V RIEQL Y PFP HEE L AA E LA KYPNA k E VV WCQEE P KNQG AWYFIQHH L EEVLPEGQKLR YAGR PAS A S PA V G YM 908
970
....*....|....*.
gi 51873036 1000 KT H LTELQR L LDT A FD 1015
Cdd:PRK09404 909 SL H KKQQEA L VED A LG 924
kgd
PRK12270 multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
117-1016
0e+00
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;
Pssm-ID: 237030 [Multi-domain]
Cd Length: 1228
Bit Score: 1021.75
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 117 QPNVDKL V EDHLA V QS LI R AY QI RGH HV A QL DPL GI --- LDA DLD ssvpadiisstdk LGFY GL DES DLD KV F hl P TTT F 193
Cdd:PRK12270 376 PADHEDE V DKNAR V ME LI H AY RV RGH LM A DT DPL EY rqr SHP DLD ------------- VLTH GL TLW DLD RE F -- P VGG F 440
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 194 i GG Q E S a LP LR E I IRR L EMA YC QHI G V E F M F I N D L EQ CQ W IRQKF E T P g IMQF T N EE KRTL L AR L VRSTR FE E FLQ R K WS 273
Cdd:PRK12270 441 - GG K E R - MK LR D I LGV L RDS YC RTV G I E Y M H I Q D P EQ RR W LQERV E R P - HEKP T R EE QKRI L SK L NAAEA FE T FLQ T K YV 517
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 274 SE KRF G LEG C E V LIP A L KTII D KSS E N G V D Y V IM GM P HRGRLNVLAN VIR K ELE QIF CQ F DSK L E - AADE GSGDVKYHLG 352
Cdd:PRK12270 518 GQ KRF S LEG G E S LIP L L DAVL D QAA E H G L D E V VI GM A HRGRLNVLAN IVG K PYS QIF RE F EGN L D p RSAQ GSGDVKYHLG 597
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 353 --- MYHR rinr VTDRN I TL SL V ANPSHLEA A DPV VM G KTK A E Q FYCGD - T EG KK V MS ILLHGDAAFAGQG I V Y ET FH LS D 428
Cdd:PRK12270 598 aeg TFTQ ---- MFGDE I KV SL A ANPSHLEA V DPV LE G IVR A K Q DRLDK g E EG FT V LP ILLHGDAAFAGQG V V A ET LN LS Q 673
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 429 L PS Y T T H GT V H V VVNNQ I GFTT D P RMA RSS P Y P TDVA RVVN APIFHVN S DDPEAV MY V CKV A A E W R ST FHKDVV V DLVCY 508
Cdd:PRK12270 674 L RG Y R T G GT I H I VVNNQ V GFTT A P ESS RSS E Y A TDVA KMIQ APIFHVN G DDPEAV VR V ARL A F E Y R QR FHKDVV I DLVCY 753
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 509 RR N GHNE M D E P MF TQPLMY KQ I RKQKP V LQK Y A E L L VSQ G VVNQP E Y E EEISK Y DKIC E EA F ARSKDEK ilhi K H wl DSP 588
Cdd:PRK12270 754 RR R GHNE G D D P SM TQPLMY DL I DAKRS V RKL Y T E A L IGR G DITVE E A E QALRD Y QGQL E RV F NEVREAE ---- K K -- PPE 827
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 589 W P GFFTL D GQ P rs MSCPS T GLTEDI L TH IG NVASSV P v E N FT I H GG L SRI L KT R G EM VKNRTV DWA LA E YM AFGSLL K EG 668
Cdd:PRK12270 828 P P ESVES D QG P -- PAGVD T AVSAEV L ER IG DAHVNL P - E G FT V H PK L KPL L EK R R EM AREGGI DWA FG E LL AFGSLL L EG 904
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 669 IHI RLSGQD VE RGTFS H RH H VL H D QNVDKRTC i P MNH L WPN Q APYT V CN S S LSEY GVL GFE L G FAMAS P N ALVLWEAQFG 748
Cdd:PRK12270 905 TPV RLSGQD SR RGTFS Q RH A VL I D RETGEEYT - P LQN L SDD Q GKFL V YD S L LSEY AAM GFE Y G YSVER P D ALVLWEAQFG 983
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 749 DF H N T AQ C IID Q FI CP G Q AKW VRQN G I VLLLPHG M EG M GP E HSSAR P ERFLQ M C NDD pdvlpdlkeanfdinqlydc N WV 828
Cdd:PRK12270 984 DF A N G AQ T IID E FI SS G E AKW GQRS G V VLLLPHG Y EG Q GP D HSSAR I ERFLQ L C AEG -------------------- N MT 1043
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 829 V VNC STP G N F FH V LRRQ I L LPF R K PL II FTPKS L LR HPE A R S SFDEMLP G T h F QR VI PE dg P AAQNPEN V K R L L F C T GK V 908
Cdd:PRK12270 1044 V AQP STP A N Y FH L LRRQ A L SGP R R PL VV FTPKS M LR LKA A V S DVEDFTE G K - F RP VI DD -- P TVDDGAK V R R V L L C S GK L 1120
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 909 YYDL TRE R KARD m VGQV AI T R I EQL S P F P FDL L LKEVQK YPNA - E LA W C QEE HK NQG YYDYVKPR L RTTISRAKPVWYAG 987
Cdd:PRK12270 1121 YYDL AAR R EKDG - RDDT AI V R V EQL Y P L P RAE L REALAR YPNA t E VV W V QEE PA NQG AWPFMALN L PELLPDGRRLRRVS 1199
890 900
....*....|....*....|....*....
gi 51873036 988 R DPA A A PATG NK K T H LT E L Q R LLD T AF DL 1016
Cdd:PRK12270 1200 R PAS A S PATG SA K V H AV E Q Q E LLD E AF AR 1228
2oxo_dh_E1
TIGR00239 2-oxoglutarate dehydrogenase, E1 component; The 2-oxoglutarate dehydrogenase complex consists ...
49-1014
0e+00
2-oxoglutarate dehydrogenase, E1 component; The 2-oxoglutarate dehydrogenase complex consists of this thiamine pyrophosphate-binding subunit (E1), dihydrolipoamide succinyltransferase (E2), and lipoamide dehydrogenase (E3). The E1 ortholog from Corynebacterium glutamicum is unusual in having an N-terminal extension that resembles the dihydrolipoamide succinyltransferase (E2) component of 2-oxoglutarate dehydrogenase. [Energy metabolism, TCA cycle]
Pssm-ID: 161785 [Multi-domain]
Cd Length: 929
Bit Score: 992.84
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 49 F LSG TSSN Y V EE M Y CAW L EN P K SV HK SW DIF F RNTNAGA P PGTAYQ SP LPLSRGS LA AV A HAQ S LVEAQ P nv D KL V EDHL 128
Cdd:TIGR00239 1 Y LSG ANQS Y I EE L Y EDY L TD P D SV DA SW RST F DQLPGPG P APDQFH SP TRSYFRR LA KD A SRG S VTISD P -- D TN V SQVK 78
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 129 AV Q s LIRAY QI RGH HV A Q LDPLG ILDA D ldss VPADI isstd K L G FYGL D E S DL DKV F HLPTTTFIGGQESA L PLR E IIR 208
Cdd:TIGR00239 79 VL Q - LIRAY RF RGH LH A N LDPLG LKQQ D ---- KVPEL ----- D L S FYGL T E A DL QET F NIGSFVSGKDATMK L SNL E LLQ 148
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 209 R L EMA YC QH IG V E F M F I NDL E QCQ W IR Q KF E TPGIM QF TN EEK RTL L A RL VRSTR FE E FL QR K WSSE KRF G LEG CEV L I P 288
Cdd:TIGR00239 149 A L KQT YC GS IG A E Y M H I TST E EKR W LQ Q RI E SGERA QF NS EEK KRF L S RL TAAEG FE R FL GA K FPGA KRF S LEG LDA L V P 228
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 289 A LK T II DK S SEN G VDY V IM GM P HRGRLNVL A NV IR K EL E Q IF CQ F DS K LEAAD - E G S GDVKYH L G MYHRRIN r VTDRNIT 367
Cdd:TIGR00239 229 M LK E II RH S VNS G TRD V VL GM A HRGRLNVL V NV LG K PP E D IF SE F AG K HKSHL p D G T GDVKYH M G RFSSDFT - TDGKLVH 307
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 368 L S L VA NPSHLE AAD PVV M G K T K A EQFYCG D - T E GK KV MS IL L HGDAAFAGQG I V Y ET FHL S D L PS Y TTH GT V H VVV NNQI 446
Cdd:TIGR00239 308 L A L AF NPSHLE IVS PVV I G S T R A RLDRLN D s P E ST KV LA IL I HGDAAFAGQG V V Q ET LNM S K L RG Y SVG GT I H III NNQI 387
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 447 GFTT D P RM ARS S PY PT D V A RVVN APIFHVN S DDPEAV MYVCKV A A E W R S TF HK DV VV DLV C YRR N GHNE M DEP MF TQPLM 526
Cdd:TIGR00239 388 GFTT N P LD ARS T PY CS D L A KMIQ APIFHVN A DDPEAV AFATRL A V E Y R N TF KR DV FI DLV G YRR H GHNE A DEP SA TQPLM 467
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 527 Y KQ I R K QKPVLQK YA EL LVS Q GV VN qpey EE EISKYDKICEE A FARSKD e KILHIKHWLDSPWPGFFT L D g QPRSMSC P S 606
Cdd:TIGR00239 468 Y QK I K K HPTPRKV YA DK LVS E GV AT ---- EE DVTEMVNLYRD A LEAADC - VVPSWREMNTASFTWSPE L N - HEWDEEY P N 541
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 607 T g LTEDI L THIGNVA S S VP v E NFTI H GGLSR I LKT R GEMVK -- NRTV DW AL AE YM AF GS L LKE GI HI RLSG Q D V ERGTF S 684
Cdd:TIGR00239 542 K - VEMKR L QELAKRI S E VP - E GVEM H SRVAK I YFD R TKAMA ag EKLF DW GG AE NL AF AT L VDD GI PV RLSG E D S ERGTF F 619
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 685 H RH H VLHDQ N v DKR T CI P MN HL WPN Q APYT V C NS S LSE YG VLGFE L G F A MA SP NA LV L WEAQFGDF H N T AQ CI IDQFI CP 764
Cdd:TIGR00239 620 Q RH A VLHDQ S - NGS T YT P LQ HL HNG Q GAFR V W NS V LSE ES VLGFE Y G Y A TT SP RT LV I WEAQFGDF A N G AQ VV IDQFI SS 698
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 765 G QA KW VRQN G I V L LLPHG M EG M GPEHSS A R P ERFLQ MCNDD pdvlpdlkeanfdinqlydc N WV V VNCS TP GNF FH V LRR 844
Cdd:TIGR00239 699 G EQ KW GQMS G L V M LLPHG Y EG Q GPEHSS G R L ERFLQ LAAEQ -------------------- N MQ V CVPT TP AQV FH I LRR 758
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 845 Q I L LPF R K PL IIFT PKSLLRHP E A R SS FD E MLP GT h FQ R VI P -- E DGPAAQN PE N VKRL LF C T GKVYYDL t R E RKARDMV 922
Cdd:TIGR00239 759 Q A L RGM R R PL VVMS PKSLLRHP L A V SS LE E LAE GT - FQ P VI G ei E ESGLSLD PE G VKRL VL C S GKVYYDL - H E QRRKNGQ 836
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 923 GQ VAI T RIEQL S PFP FDLLLKEV Q K YPN - A E LA WCQEE HK N Q G YYD Y VK P R LR TT I SRAKP V W YAGR DPA A A PA T G NKKT 1001
Cdd:TIGR00239 837 KD VAI V RIEQL Y PFP HKAVKEVL Q Q YPN l K E IV WCQEE PL N M G AWY Y SQ P H LR EV I PEGVS V R YAGR PAS A S PA V G YMSL 916
970
....*....|...
gi 51873036 1002 H LTEL Q R LL DT A F 1014
Cdd:TIGR00239 917 H QKQQ Q D LL ND A L 929
TPP_E1_OGDC_like
cd02016 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed ...
264-527
1.25e-179
Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of 2-oxoglutarate to succinyl-CoA and carbon dioxide, a key reaction of the tricarboxylic acid cycle.
Pssm-ID: 238974 [Multi-domain]
Cd Length: 265
Bit Score: 522.47
E-value: 1.25e-179
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 264 FE E FL QR K WSSE KRFGLEG C E V LIPAL KTI ID KSS E N GV DY V IM GM P HRGRLNVLANV IR K E LEQIF CQ F DS K L E AAD -- 341
Cdd:cd02016 1 FE Q FL AT K FPGQ KRFGLEG A E S LIPAL DEL ID RAA E L GV EE V VI GM A HRGRLNVLANV LG K P LEQIF SE F EG K S E FPE dd 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 342 EGSGDVKYHLG MYHR R INRV t DRNIT LSL VA NPSHLEA AD PVVMGKT K A E Q F Y C GD T E GK KV MS IL L HGDAAFAGQG I VY 421
Cdd:cd02016 81 EGSGDVKYHLG YSSD R KTPS - GKKVH LSL AP NPSHLEA VN PVVMGKT R A K Q D Y R GD G E RD KV LP IL I HGDAAFAGQG V VY 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 422 ET FH LS D LP S YTT H GT V H V VVNNQIGFTTDPR MA RSSPY P TDVA RVVN APIFHVN S DDPEAV MYVCKV A A E W R ST F H KDV 501
Cdd:cd02016 160 ET LN LS N LP G YTT G GT I H I VVNNQIGFTTDPR DS RSSPY C TDVA KMIG APIFHVN G DDPEAV VRATRL A L E Y R QK F K KDV 239
250 260
....*....|....*....|....*.
gi 51873036 502 V V DLVCYRR N GHNE M DEP M FTQPLMY 527
Cdd:cd02016 240 V I DLVCYRR H GHNE L DEP S FTQPLMY 265
E1_dh
pfam00676 Dehydrogenase E1 component; This family uses thiamine pyrophosphate as a cofactor. This family ...
256-582
7.07e-112
Dehydrogenase E1 component; This family uses thiamine pyrophosphate as a cofactor. This family includes pyruvate dehydrogenase, 2-oxoglutarate dehydrogenase and 2-oxoisovalerate dehydrogenase.
Pssm-ID: 395548 [Multi-domain]
Cd Length: 300
Bit Score: 348.16
E-value: 7.07e-112
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 256 A R LVRST R F E EFLQRKWSSEKRF G LEGCEVLIP A LKTI I DKSS E N G v DY V I M G mp H R GRL N V LA NVIR ke LE Q IF CQFDS 335
Cdd:pfam00676 1 R R MMTLR R M E DARDALYKRQGIR G FYHLYAGQE A AQVG I AAAL E P G - DY I I P G -- Y R DHG N L LA RGLS -- LE E IF AELYG 75
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 336 KLE aad E G S G DVKY hl G M Y HRRI NR VTDR N IT L SLVAN pshl EA A DPVVMG K T kaeqfycgdt E GKK VMS I L L H GD A A f A 415
Cdd:pfam00676 76 RVA --- K G K G GSMH -- G Y Y GAKG NR FYGG N GI L GAQVP ---- LG A GIALAA K Y ---------- R GKK EVA I T L Y GD G A - A 135
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 416 G QG IVY E TFHLSD L PSYTT hgt VH V VV NNQ I G FT T DPRM A RS S PYPT D V AR VVNA P IF HV NSD DP E AV MYVC K V AAE WRS 495
Cdd:pfam00676 136 N QG DFF E GLNFAA L WKLPV --- IF V CE NNQ Y G IS T PAER A SA S TTYA D R AR GYGI P GL HV DGM DP L AV YQAS K F AAE RAR 212
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 496 T FHKDVVVD LV C YR RN GH NEM D E P MFTQ - PLM Y KQI RK Q K PVL Q KYA E L LVS Q GV VNQP E YEEEISKYD K IC EEAF ARSK 574
Cdd:pfam00676 213 T GKGPFLIE LV T YR YG GH SMS D D P STYR t RDE Y EEV RK K K DPI Q RFK E H LVS K GV WSEE E LKAIEKEVR K EV EEAF KKAE 292
....*...
gi 51873036 575 DEKIL H IK 582
Cdd:pfam00676 293 SAPEP H PE 300
OxoGdeHyase_C
pfam16870 2-oxoglutarate dehydrogenase C-terminal; OxoGdeHyase_C is a family found immediately ...
869-1014
1.75e-80
2-oxoglutarate dehydrogenase C-terminal; OxoGdeHyase_C is a family found immediately C-terminal to Transket_pyr, pfam02779. It is found at the C-terminus of 2-oxoglutarate dehydrogenase.
Pssm-ID: 465289 [Multi-domain]
Cd Length: 147
Bit Score: 258.14
E-value: 1.75e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 869 RSS FD E ML PGTHFQRVIP EDG P A a QN PE N VKR LLF C T GKVYYDL TR ER KA R DMVGQ VAI T RIEQL S PFPFDLL LK E VQ KY 948
Cdd:pfam16870 1 RSS LE E FT PGTHFQRVIP DPE P L - VD PE K VKR VVL C S GKVYYDL LK ER EE R GGIKD VAI V RIEQL Y PFPFDLL KE E LD KY 79
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 51873036 949 PNA - E LA WCQEE H KNQG YYDY V K PRL R T TISRA - KPVW YAGR D P A A A PATG N K KT HL T E LQR LLD T AF 1014
Cdd:pfam16870 80 PNA a E IV WCQEE P KNQG AWSF V Q PRL E T VLNET g HRLR YAGR P P S A S PATG S K SV HL A E QEA LLD D AF 147
Transket_pyr
pfam02779 Transketolase, pyrimidine binding domain; This family includes transketolase enzymes, pyruvate ...
649-864
2.93e-53
Transketolase, pyrimidine binding domain; This family includes transketolase enzymes, pyruvate dehydrogenases, and branched chain alpha-keto acid decarboxylases.
Pssm-ID: 460692 [Multi-domain]
Cd Length: 174
Bit Score: 183.52
E-value: 2.93e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 649 RTVDWAL A EYM A FGS L L K EGIHIRLS G Q D VER GTF SHRHHV LH D qnvdkrtcipmnhlwpn Q APYT V CNSSLS E YGVL GF 728
Cdd:pfam02779 1 KKIATRK A SGE A LAE L A K RDPRVVGG G A D LAG GTF TVTKGL LH P ----------------- Q GAGR V IDTGIA E QAMV GF 63
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 729 EL G F A MAS P N a L VLW EA Q F G DF H N taqc II D QF I CP G Q A KWVRQNG - I V LLL P H G MEGM GP E H S S ARPER FL QMCN ddpd 807
Cdd:pfam02779 64 AN G M A LHG P L - L PPV EA T F S DF L N ---- RA D DA I RH G A A LGKLPVP f V V TRD P I G VGED GP T H Q S VEDLA FL RAIP ---- 134
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 51873036 808 vlpdlkeanfdinqlydc NWV VV NC S TPGNFFHV LR RQ I LLPF RKP LIIFT P KS LLR 864
Cdd:pfam02779 135 ------------------ GLK VV RP S DAAETKGL LR AA I RRDG RKP VVLRL P RQ LLR 173
Transket_pyr
smart00861 Transketolase, pyrimidine binding domain; Transketolase (TK) catalyzes the reversible transfer ...
717-864
4.19e-22
Transketolase, pyrimidine binding domain; Transketolase (TK) catalyzes the reversible transfer of a two-carbon ketol unit from xylulose 5-phosphate to an aldose receptor, such as ribose 5-phosphate, to form sedoheptulose 7-phosphate and glyceraldehyde 3- phosphate. This enzyme, together with transaldolase, provides a link between the glycolytic and pentose-phosphate pathways. TK requires thiamine pyrophosphate as a cofactor. In most sources where TK has been purified, it is a homodimer of approximately 70 Kd subunits. TK sequences from a variety of eukaryotic and prokaryotic sources show that the enzyme has been evolutionarily conserved. In the peroxisomes of methylotrophic yeast Hansenula polymorpha, there is a highly related enzyme, dihydroxy-acetone synthase (DHAS) (also known as formaldehyde transketolase), which exhibits a very unusual specificity by including formaldehyde amongst its substrates.
Pssm-ID: 214865 [Multi-domain]
Cd Length: 136
Bit Score: 92.93
E-value: 4.19e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 717 NSSLS E YGVL GF EL G F A MA spn A L VLWEAQ F GD F HNT A QCI I DQFIC pgqak WVRQNGIVLLLPH G ME G M - GP E H S S ARP 795
Cdd:smart00861 19 DTGIA E QAMV GF AA G L A LH --- G L RPVVEI F FT F FDR A KDQ I RSAGA ----- SGNVPVVFRHDGG G GV G E d GP T H H S IED 90
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 796 E - RFLQM cnddpdvlpdlkeanfdinqlyd CNWV VV NC S T P GNFFHV LR RQ I LLP f RKPL I IFTP KSL L R 864
Cdd:smart00861 91 E a LLRAI ----------------------- PGLK VV AP S D P AEAKGL LR AA I RDD - GPVV I RLER KSL Y R 136
2-oxogl_dehyd_N
pfam16078 2-oxoglutarate dehydrogenase N-terminus; This domain is found at the N-terminus of ...
47-87
1.25e-15
2-oxoglutarate dehydrogenase N-terminus; This domain is found at the N-terminus of 2-oxoglutarate dehydrogenases.
Pssm-ID: 465008 [Multi-domain]
Cd Length: 41
Bit Score: 71.41
E-value: 1.25e-15
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 51873036 47 EP FLSG TSSN Y V EE M Y CAW L EN P K SV HK SW DIF F R N TNA G A 87
Cdd:pfam16078 1 DS FLSG ANAA Y I EE L Y EQY L KD P S SV DP SW RAY F D N LDD G E 41
TPP_E1_PDC_ADC_BCADC
cd02000 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; ...
400-572
1.11e-11
Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain alpha-keto acid dehydrogenase/2-oxoisovalerate dehydrogenase complex (BCADC). PDC catalyzes the irreversible oxidative decarboxylation of pyruvate to produce acetyl-CoA in the bridging step between glycolysis and the citric acid cycle. ADC participates in the breakdown of acetoin while BCADC participates in the breakdown of branched chain amino acids. BCADC catalyzes the oxidative decarboxylation of 4-methyl-2-oxopentanoate, 3-methyl-2-oxopentanoate and 3-methyl-2-oxobutanoate (branched chain 2-oxo acids derived from the transamination of leucine, valine and isoleucine).
Pssm-ID: 238958 [Multi-domain]
Cd Length: 293
Bit Score: 66.75
E-value: 1.11e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 400 G KKVMSILLH GD A A f AGQ G IVY E TFHLS --- D LP sytthg TVH V VV NN QIGFT T d P R m A R SSPYPTDVA R VVNA -- P IFH 474
Cdd:cd02000 124 G EDRVAVCFF GD G A - TNE G DFH E ALNFA alw K LP ------ VIF V CE NN GYAIS T - P T - S R QTAGTSIAD R AAAY gi P GIR 194
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51873036 475 V NSD D PE AV MYVC K V A A E W - R ST f HKDVVVDL V C YR RN GH NEM D E P M ftqpl M Y K ----- QIR K QKPVLQKYAEL L VSQ G 548
Cdd:cd02000 195 V DGN D VL AV YEAA K E A V E R a R AG - GGPTLIEA V T YR LG GH STS D D P S ----- R Y R tkeev EEW K KRDPILRLRKY L IEA G 268
170 180
....*....|....*....|....
gi 51873036 549 VVNQP E YEEEISKYDKIC EEA FAR 572
Cdd:cd02000 269 ILTEE E LAAIEAEVKAEV EEA VEF 292
kgd
PRK12270 multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
57-112
1.86e-03
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;
Pssm-ID: 237030 [Multi-domain]
Cd Length: 1228
Bit Score: 42.18
E-value: 1.86e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 51873036 57 Y VEEMY CAW L EN P K SV HK SW DI FF RNTNA G APPGTAYQSPLPLSRG S LA A V A H A QS 112
Cdd:PRK12270 10 L VEEMY QQY L AD P N SV DP SW RE FF ADYGP G STAAPTAAAAAAAAAA S AP A A A P A AK 65
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
