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Conserved domains on  [gi|4506033|ref|NP_002713|]
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pancreatic polypeptide prohormone isoform 1 preproprotein [Homo sapiens]

Protein Classification

PAH domain-containing protein( domain architecture ID 10645658)

PAH domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PAH smart00309
Pancreatic hormones / neuropeptide F / peptide YY family; Pancreatic hormone is a regulator of ...
 30-65 2.91e-14

Pancreatic hormones / neuropeptide F / peptide YY family; Pancreatic hormone is a regulator of pancreatic and gastrointestinal functions.


:

Pssm-ID: 197643  Cd Length: 36  Bit Score: 60.81  E-value: 2.91e-14
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 4506033     30 APLEPVYPGDNATPEQMAQYAADLRRYINMLTRPRY 65
Cdd:smart00309  1 MPSKPERPGDDASPEDLRQYLAALREYINLITRPRF 36
 
Name Accession Description Interval E-value
PAH smart00309
Pancreatic hormones / neuropeptide F / peptide YY family; Pancreatic hormone is a regulator of ...
 30-65 2.91e-14

Pancreatic hormones / neuropeptide F / peptide YY family; Pancreatic hormone is a regulator of pancreatic and gastrointestinal functions.


Pssm-ID: 197643  Cd Length: 36  Bit Score: 60.81  E-value: 2.91e-14
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 4506033     30 APLEPVYPGDNATPEQMAQYAADLRRYINMLTRPRY 65
Cdd:smart00309  1 MPSKPERPGDDASPEDLRQYLAALREYINLITRPRF 36
PAH cd00126
Pancreatic Hormone domain, a regulator of pancreatic and gastrointestinal functions; ...
 30-65 1.99e-13

Pancreatic Hormone domain, a regulator of pancreatic and gastrointestinal functions; neuropeptide Y (NPY)b, peptide YY (PYY), and pancreatic polypetide (PP) are closely related; propeptide is enzymatically cleaved to yield the mature active peptide with amidated C-terminal ends; receptor binding and activation functions may reside in the N- and C-termini respectively; occurs in neurons, intestinal endocrine cells, and pancreas; exist as monomers and dimers


Pssm-ID: 238072  Cd Length: 36  Bit Score: 58.43  E-value: 1.99e-13
                       10        20        30
               ....*....|....*....|....*....|....*.
gi 4506033  30 APLEPVYPGDNATPEQMAQYAADLRRYINMLTRPRY 65
Cdd:cd00126  1 MPSKPENPGDDASPEELRQYLAALREYINLITRPRF 36
Hormone_3 pfam00159
Pancreatic hormone peptide;
31-65 6.36e-11

Pancreatic hormone peptide;


Pssm-ID: 459693  Cd Length: 35  Bit Score: 52.13  E-value: 6.36e-11
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 4506033    31 PLEPVYPGDNATPEQMAQYAADLRRYINMLTRPRY 65
Cdd:pfam00159  1 PAPPERPKEFASPEELRRYLAQLNEYYNLIGRPRF 35
 
Name Accession Description Interval E-value
PAH smart00309
Pancreatic hormones / neuropeptide F / peptide YY family; Pancreatic hormone is a regulator of ...
 30-65 2.91e-14

Pancreatic hormones / neuropeptide F / peptide YY family; Pancreatic hormone is a regulator of pancreatic and gastrointestinal functions.


Pssm-ID: 197643  Cd Length: 36  Bit Score: 60.81  E-value: 2.91e-14
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 4506033     30 APLEPVYPGDNATPEQMAQYAADLRRYINMLTRPRY 65
Cdd:smart00309  1 MPSKPERPGDDASPEDLRQYLAALREYINLITRPRF 36
PAH cd00126
Pancreatic Hormone domain, a regulator of pancreatic and gastrointestinal functions; ...
 30-65 1.99e-13

Pancreatic Hormone domain, a regulator of pancreatic and gastrointestinal functions; neuropeptide Y (NPY)b, peptide YY (PYY), and pancreatic polypetide (PP) are closely related; propeptide is enzymatically cleaved to yield the mature active peptide with amidated C-terminal ends; receptor binding and activation functions may reside in the N- and C-termini respectively; occurs in neurons, intestinal endocrine cells, and pancreas; exist as monomers and dimers


Pssm-ID: 238072  Cd Length: 36  Bit Score: 58.43  E-value: 1.99e-13
                       10        20        30
               ....*....|....*....|....*....|....*.
gi 4506033  30 APLEPVYPGDNATPEQMAQYAADLRRYINMLTRPRY 65
Cdd:cd00126  1 MPSKPENPGDDASPEELRQYLAALREYINLITRPRF 36
Hormone_3 pfam00159
Pancreatic hormone peptide;
31-65 6.36e-11

Pancreatic hormone peptide;


Pssm-ID: 459693  Cd Length: 35  Bit Score: 52.13  E-value: 6.36e-11
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 4506033    31 PLEPVYPGDNATPEQMAQYAADLRRYINMLTRPRY 65
Cdd:pfam00159  1 PAPPERPKEFASPEELRRYLAQLNEYYNLIGRPRF 35
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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