NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|4506041|ref|NP_002716|]
View 

prolargin precursor [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
106-305 2.94e-22

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 97.31  E-value: 2.94e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506041  106 YLYLQNNFITELPvESFQNATGLRWINLDNNRIRKIDqRVLEKLPGLVFLYMEKNQLEEVPSALPR--NLEQLRLSQNHI 183
Cdd:COG4886 117 SLDLSGNQLTDLP-EELANLTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLPEELGNltNLKELDLSNNQI 194

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506041  184 SRIppgvfsklenlllldlqhnrlsdgvfkPDTFHGLKNLMQLNLAHNILRKMPPRVP--TAIHQLYLDSNKIETIPNgy 261
Cdd:COG4886 195 TDL---------------------------PEPLGNLTNLEELDLSGNQLTDLPEPLAnlTNLETLDLSNNQLTDLPE-- 245

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 4506041  262 FKSFPNLAFIRLNYNKLTDrgLPKnSFNISNLLVLHLSHNRISS 305
Cdd:COG4886 246 LGNLTNLEELDLSNNQLTD--LPP-LANLTNLKTLDLSNNQLTD 286
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 244-374 5.85e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 55.95  E-value: 5.85e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506041  244 IHQLYLDSNKIETIPNgyFKSFPNLAFIRLNYNKLTdrgLPKNSFNISNLLVLHLSHNRISSVPAINN--RLEHLYLNNN 321
Cdd:cd21340   4 ITHLYLNDKNITKIDN--LSLCKNLKVLYLYDNKIT---KIENLEFLTNLTHLYLQNNQIEKIENLENlvNLKKLYLGGN 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 4506041  322 SIEKINGtqicpndlvafhdfssdLENVPHLRYLRLDGNYLkppiPLDLMMCF 374
Cdd:cd21340  79 RISVVEG-----------------LENLTNLEELHIENQRL----PPGEKLTF 110
LRRNT smart00013
Leucine rich repeat N-terminal domain;
72-107 2.38e-06

Leucine rich repeat N-terminal domain;


:

Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 43.85  E-value: 2.38e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 4506041      72 DCPRECYCPPdfpSALYCDSRNLRKVPVIPPRIHYL 107
Cdd:smart00013   1 ACPAPCNCSG---TAVDCSGRGLTEVPLDLPPDTTL 33
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
106-305 2.94e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 97.31  E-value: 2.94e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506041  106 YLYLQNNFITELPvESFQNATGLRWINLDNNRIRKIDqRVLEKLPGLVFLYMEKNQLEEVPSALPR--NLEQLRLSQNHI 183
Cdd:COG4886 117 SLDLSGNQLTDLP-EELANLTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLPEELGNltNLKELDLSNNQI 194

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506041  184 SRIppgvfsklenlllldlqhnrlsdgvfkPDTFHGLKNLMQLNLAHNILRKMPPRVP--TAIHQLYLDSNKIETIPNgy 261
Cdd:COG4886 195 TDL---------------------------PEPLGNLTNLEELDLSGNQLTDLPEPLAnlTNLETLDLSNNQLTDLPE-- 245

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 4506041  262 FKSFPNLAFIRLNYNKLTDrgLPKnSFNISNLLVLHLSHNRISS 305
Cdd:COG4886 246 LGNLTNLEELDLSNNQLTD--LPP-LANLTNLKTLDLSNNQLTD 286
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
133-353 2.84e-12

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 68.18  E-value: 2.84e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506041   133 LDNNRIRKIDqrvlEKLPG-LVFLYMEKNQLEEVPSALPRNLEQLRLSQNHISRIPPGVFSKLENLLLLdlqHNRLSdgv 211
Cdd:PRK15370 206 LDNNELKSLP----ENLQGnIKTLYANSNQLTSIPATLPDTIQEMELSINRITELPERLPSALQSLDLF---HNKIS--- 275

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506041   212 FKPDTFHglKNLMQLNLAHNILRKMPPRVPTAIHQLYLDSNKI----ETIPngyfksfPNLAFIRLNYNKLTD--RGLPk 285
Cdd:PRK15370 276 CLPENLP--EELRYLSVYDNSIRTLPAHLPSGITHLNVQSNSLtalpETLP-------PGLKTLEAGENALTSlpASLP- 345

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4506041   286 nsfniSNLLVLHLSHNRISSVP-AINNRLEHLYLNNNSIekINGTQICPNDLVAFHDFSSDL----ENVPHLR 353
Cdd:PRK15370 346 -----PELQVLDVSKNQITVLPeTLPPTITTLDVSRNAL--TNLPENLPAALQIMQASRNNLvrlpESLPHFR 411
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 103-360 4.03e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 62.11  E-value: 4.03e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506041  103 RIHYLYLQNNFITELPV-ESFQNatgLRWINLDNNRIRKIDQrvLEKLPGLVFLYMEKNQLEEVP--SALpRNLEQLRLS 179
Cdd:cd21340   3 RITHLYLNDKNITKIDNlSLCKN---LKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEnlENL-VNLKKLYLG 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506041  180 QNHISRIppgvfsklenlllldlqhnrlsDGvfkpdtFHGLKNLMQLNLAHNILrkmPPRvptaiHQLYLDSNKIETIPN 259
Cdd:cd21340  77 GNRISVV----------------------EG------LENLTNLEELHIENQRL---PPG-----EKLTFDPRSLAALSN 120

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506041  260 gyfksfpnlafirlnynkltdrglpknsfnisNLLVLHLSHNRISSVPAINN--RLEHLYLNNNSIEKingtqicpndlv 337
Cdd:cd21340 121 --------------------------------SLRVLNISGNNIDSLEPLAPlrNLEQLDASNNQISD------------ 156

                       250       260
                ....*....|....*....|...
gi 4506041  338 aFHDFSSDLENVPHLRYLRLDGN 360
Cdd:cd21340 157 -LEELLDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
102-162 4.23e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.22  E-value: 4.23e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4506041    102 PRIHYLYLQNNFITELPVESFQNATGLRWINLDNNRIRKIDQRVLEKLPGLVFLYMEKNQL 162
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 244-374 5.85e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 55.95  E-value: 5.85e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506041  244 IHQLYLDSNKIETIPNgyFKSFPNLAFIRLNYNKLTdrgLPKNSFNISNLLVLHLSHNRISSVPAINN--RLEHLYLNNN 321
Cdd:cd21340   4 ITHLYLNDKNITKIDN--LSLCKNLKVLYLYDNKIT---KIENLEFLTNLTHLYLQNNQIEKIENLENlvNLKKLYLGGN 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 4506041  322 SIEKINGtqicpndlvafhdfssdLENVPHLRYLRLDGNYLkppiPLDLMMCF 374
Cdd:cd21340  79 RISVVEG-----------------LENLTNLEELHIENQRL----PPGEKLTF 110
LRRNT smart00013
Leucine rich repeat N-terminal domain;
72-107 2.38e-06

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 43.85  E-value: 2.38e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 4506041      72 DCPRECYCPPdfpSALYCDSRNLRKVPVIPPRIHYL 107
Cdd:smart00013   1 ACPAPCNCSG---TAVDCSGRGLTEVPLDLPPDTTL 33
LRR_8 pfam13855
Leucine rich repeat;
291-362 3.61e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.97  E-value: 3.61e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4506041    291 SNLLVLHLSHNRISSVPAI----NNRLEHLYLNNNSIEKINGtqicpndlVAFHDFssdlenvPHLRYLRLDGNYL 362
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGafkgLSNLKVLDLSNNLLTTLSP--------GAFSGL-------PSLRYLDLSGNRL 61
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 72-102 9.41e-04

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 36.45  E-value: 9.41e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 4506041     72 DCPRECYCPPdfpSALYCDSRNLRKVPVIPP 102
Cdd:pfam01462   1 ACPVPCHCSA---TVVNCSDRGLTAVPRDLP 28
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
106-305 2.94e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 97.31  E-value: 2.94e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506041  106 YLYLQNNFITELPvESFQNATGLRWINLDNNRIRKIDqRVLEKLPGLVFLYMEKNQLEEVPSALPR--NLEQLRLSQNHI 183
Cdd:COG4886 117 SLDLSGNQLTDLP-EELANLTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLPEELGNltNLKELDLSNNQI 194

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506041  184 SRIppgvfsklenlllldlqhnrlsdgvfkPDTFHGLKNLMQLNLAHNILRKMPPRVP--TAIHQLYLDSNKIETIPNgy 261
Cdd:COG4886 195 TDL---------------------------PEPLGNLTNLEELDLSGNQLTDLPEPLAnlTNLETLDLSNNQLTDLPE-- 245

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 4506041  262 FKSFPNLAFIRLNYNKLTDrgLPKnSFNISNLLVLHLSHNRISS 305
Cdd:COG4886 246 LGNLTNLEELDLSNNQLTD--LPP-LANLTNLKTLDLSNNQLTD 286
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
109-363 3.05e-20

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 91.53  E-value: 3.05e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506041  109 LQNNFITELPVESFQNATGLRWINLDNNRIrkidqrvLEKLPGLVFLYMEKNQLEEVPSALPR--NLEQLRLSQNHISRI 186
Cdd:COG4886  79 LLLLSLLLLGLTDLGDLTNLTELDLSGNEE-------LSNLTNLESLDLSGNQLTDLPEELANltNLKELDLSNNQLTDL 151

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506041  187 PPGVFSklenlllldlqhnrlsdgvfkpdtfhgLKNLMQLNLAHNILRKMPPRVP--TAIHQLYLDSNKIETIPNGyFKS 264
Cdd:COG4886 152 PEPLGN---------------------------LTNLKSLDLSNNQLTDLPEELGnlTNLKELDLSNNQITDLPEP-LGN 203

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506041  265 FPNLAFIRLNYNKLTDrgLPKNSFNISNLLVLHLSHNRISSVPAINN--RLEHLYLNNNSIEKIngtqicpndlvafhdf 342
Cdd:COG4886 204 LTNLEELDLSGNQLTD--LPEPLANLTNLETLDLSNNQLTDLPELGNltNLEELDLSNNQLTDL---------------- 265

                       250       260
                ....*....|....*....|.
gi 4506041  343 sSDLENVPHLRYLRLDGNYLK 363
Cdd:COG4886 266 -PPLANLTNLKTLDLSNNQLT 285
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
87-376 4.16e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 76.13  E-value: 4.16e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506041   87 LYCDSRNLRKVP-VIP--PRIHYLYLQNNFITELPvESFQNATGLRWINLDNNRIRKIDQrVLEKLPGLVFLYMEKNQLE 163
Cdd:COG4886 141 LDLSNNQLTDLPePLGnlTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLT 218

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506041  164 EVPSALPR--NLEQLRLSQNHISRIPpgvfsklenlllldlqhnrlsdgvfkpdtfhGLKNLMQLnlahnilrkmpprvp 241
Cdd:COG4886 219 DLPEPLANltNLETLDLSNNQLTDLP-------------------------------ELGNLTNL--------------- 252

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506041  242 taiHQLYLDSNKIETIPNgyFKSFPNLAFIRLNYNKLTDRGLPK--NSFNISNLLVLHLSHNRISSVPAINNRLEHLYLN 319
Cdd:COG4886 253 ---EELDLSNNQLTDLPP--LANLTNLKTLDLSNNQLTDLKLKEleLLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLL 327

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 4506041  320 NNSIEKINGTQICPNDLVAFHDFSSDLENVPHLRYLRLDGNYLKPPIPLDLMMCFRL 376
Cdd:COG4886 328 LLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLAL 384
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
203-370 1.28e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.81  E-value: 1.28e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506041  203 QHNRLSDGVFKPDTFHGLKNLMQLNLAHNIlrkmPPRVPTAIHQLYLDSNKIETIPNGyFKSFPNLAFIRLNYNKLTDrg 282
Cdd:COG4886  78 SLLLLSLLLLGLTDLGDLTNLTELDLSGNE----ELSNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTD-- 150

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506041  283 LPKNSFNISNLLVLHLSHNRISSVPA-INN--RLEHLYLNNNSIEkingtqicpndlvafhDFSSDLENVPHLRYLRLDG 359
Cdd:COG4886 151 LPEPLGNLTNLKSLDLSNNQLTDLPEeLGNltNLKELDLSNNQIT----------------DLPEPLGNLTNLEELDLSG 214

                       170
                ....*....|.
gi 4506041  360 NYLKpPIPLDL 370
Cdd:COG4886 215 NQLT-DLPEPL 224
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
133-353 2.84e-12

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 68.18  E-value: 2.84e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506041   133 LDNNRIRKIDqrvlEKLPG-LVFLYMEKNQLEEVPSALPRNLEQLRLSQNHISRIPPGVFSKLENLLLLdlqHNRLSdgv 211
Cdd:PRK15370 206 LDNNELKSLP----ENLQGnIKTLYANSNQLTSIPATLPDTIQEMELSINRITELPERLPSALQSLDLF---HNKIS--- 275

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506041   212 FKPDTFHglKNLMQLNLAHNILRKMPPRVPTAIHQLYLDSNKI----ETIPngyfksfPNLAFIRLNYNKLTD--RGLPk 285
Cdd:PRK15370 276 CLPENLP--EELRYLSVYDNSIRTLPAHLPSGITHLNVQSNSLtalpETLP-------PGLKTLEAGENALTSlpASLP- 345

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4506041   286 nsfniSNLLVLHLSHNRISSVP-AINNRLEHLYLNNNSIekINGTQICPNDLVAFHDFSSDL----ENVPHLR 353
Cdd:PRK15370 346 -----PELQVLDVSKNQITVLPeTLPPTITTLDVSRNAL--TNLPENLPAALQIMQASRNNLvrlpESLPHFR 411
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
102-325 1.63e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 65.34  E-value: 1.63e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506041  102 PRIHYLYLQNNFITELPvESFQNATGLRWINLDNNRIRKIDQrVLEKLPGLVFLYMEKNQLEEVP--SALPrNLEQLRLS 179
Cdd:COG4886 182 TNLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLPelGNLT-NLEELDLS 258

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506041  180 QNHISRIPPgvFSKLENLLLLDLQHNRLSDGVFKPDTFHGLKNLMQLNLAHNILRKMPPRVPTAIHQLYLDSNKIETIPN 259
Cdd:COG4886 259 NNQLTDLPP--LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVT 336

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4506041  260 GYFKSFPNLAFIRLNYNKLTDRGLPKNSFNISNLLVLHLSHNRISSVPAINNRLEHLYLNNNSIEK 325
Cdd:COG4886 337 LTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLL 402
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 103-360 4.03e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 62.11  E-value: 4.03e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506041  103 RIHYLYLQNNFITELPV-ESFQNatgLRWINLDNNRIRKIDQrvLEKLPGLVFLYMEKNQLEEVP--SALpRNLEQLRLS 179
Cdd:cd21340   3 RITHLYLNDKNITKIDNlSLCKN---LKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEnlENL-VNLKKLYLG 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506041  180 QNHISRIppgvfsklenlllldlqhnrlsDGvfkpdtFHGLKNLMQLNLAHNILrkmPPRvptaiHQLYLDSNKIETIPN 259
Cdd:cd21340  77 GNRISVV----------------------EG------LENLTNLEELHIENQRL---PPG-----EKLTFDPRSLAALSN 120

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506041  260 gyfksfpnlafirlnynkltdrglpknsfnisNLLVLHLSHNRISSVPAINN--RLEHLYLNNNSIEKingtqicpndlv 337
Cdd:cd21340 121 --------------------------------SLRVLNISGNNIDSLEPLAPlrNLEQLDASNNQISD------------ 156

                       250       260
                ....*....|....*....|...
gi 4506041  338 aFHDFSSDLENVPHLRYLRLDGN 360
Cdd:cd21340 157 -LEELLDLLSSWPSLRELDLTGN 178
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
79-362 1.97e-10

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 62.49  E-value: 1.97e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506041    79 CPPDFPSALYCDSRNLRKVPVIPPRIHYLYLQNNFITELPVEsfqnATGLRWINLDNNRIRKidqrvLEKLP-GLVFLYM 157
Cdd:PRK15387 219 CLPAHITTLVIPDNNLTSLPALPPELRTLEVSGNQLTSLPVL----PPGLLELSIFSNPLTH-----LPALPsGLCKLWI 289

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506041   158 EKNQLEEVPsALPRNLEQLRLSQNHISRIP--PGVFSKLENLLLLDLQHNRLSDGvfkpdtfhglknLMQLNLAHNILRK 235
Cdd:PRK15387 290 FGNQLTSLP-VLPPGLQELSVSDNQLASLPalPSELCKLWAYNNQLTSLPTLPSG------------LQELSVSDNQLAS 356

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506041   236 MPPrVPTAIHQLYLDSNKIETIPngyfksfpnlafirlnynkltdrGLPknsfniSNLLVLHLSHNRISSVPAINNRLEH 315
Cdd:PRK15387 357 LPT-LPSELYKLWAYNNRLTSLP-----------------------ALP------SGLKELIVSGNRLTSLPVLPSELKE 406

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 4506041   316 LYLNNNsieKINGTQICPNDLVAFHDFSSDLENVP----HLR---YLRLDGNYL 362
Cdd:PRK15387 407 LMVSGN---RLTSLPMLPSGLLSLSVYRNQLTRLPesliHLSsetTVNLEGNPL 457
LRR_8 pfam13855
Leucine rich repeat;
102-162 4.23e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.22  E-value: 4.23e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4506041    102 PRIHYLYLQNNFITELPVESFQNATGLRWINLDNNRIRKIDQRVLEKLPGLVFLYMEKNQL 162
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 89-346 3.79e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 58.71  E-value: 3.79e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506041    89 CDSRNLRKVPV--------IPP------RIHYLYLQNN-FITELPVEsFQNATGLRWINLDNNRIR-KIDQRVLEkLPGL 152
Cdd:PLN00113 377 CSSGNLFKLILfsnslegeIPKslgacrSLRRVRLQDNsFSGELPSE-FTKLPLVYFLDISNNNLQgRINSRKWD-MPSL 454

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506041   153 VFLYMEKNQ-LEEVP-SALPRNLEQLRLSQNHISRIPPGVFSKLENLLLLDLQHNRLSDGVfkPDTFHGLKNLMQLNLAH 230
Cdd:PLN00113 455 QMLSLARNKfFGGLPdSFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEI--PDELSSCKKLVSLDLSH 532

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506041   231 NILRKmpprvptaihqlyldsnkieTIPNGyFKSFPNLAFIRLNYNKLTDRgLPKNSFNISNLLVLHLSHNRI-SSVPAI 309
Cdd:PLN00113 533 NQLSG--------------------QIPAS-FSEMPVLSQLDLSQNQLSGE-IPKNLGNVESLVQVNISHNHLhGSLPST 590

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 4506041   310 NNRLehlylnnnsieKINGTQICPNDLVAFHDFSSDL 346
Cdd:PLN00113 591 GAFL-----------AINASAVAGNIDLCGGDTTSGL 616
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 244-374 5.85e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 55.95  E-value: 5.85e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506041  244 IHQLYLDSNKIETIPNgyFKSFPNLAFIRLNYNKLTdrgLPKNSFNISNLLVLHLSHNRISSVPAINN--RLEHLYLNNN 321
Cdd:cd21340   4 ITHLYLNDKNITKIDN--LSLCKNLKVLYLYDNKIT---KIENLEFLTNLTHLYLQNNQIEKIENLENlvNLKKLYLGGN 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 4506041  322 SIEKINGtqicpndlvafhdfssdLENVPHLRYLRLDGNYLkppiPLDLMMCF 374
Cdd:cd21340  79 RISVVEG-----------------LENLTNLEELHIENQRL----PPGEKLTF 110
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
80-281 3.03e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 52.39  E-value: 3.03e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506041    80 PPDFPSAL-YCD--SRNLRKVPV-IPPRIHYLYLQNNFITELPvesfqnatglrwinldnnrirkidqrvlEKLP-GLVF 154
Cdd:PRK15370 278 PENLPEELrYLSvyDNSIRTLPAhLPSGITHLNVQSNSLTALP----------------------------ETLPpGLKT 329

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506041   155 LYMEKNQLEEVPSALPRNLEQLRLSQNHISRIPPGVfsklenlllldlqhnrlsdgvfkPDTfhglknLMQLNLAHNILR 234
Cdd:PRK15370 330 LEAGENALTSLPASLPPELQVLDVSKNQITVLPETL-----------------------PPT------ITTLDVSRNALT 380

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 4506041   235 KMPPRVPTAIHQLYLDSNKIETIPNG---YFKSFPNLAFIRLNYNKLTDR 281
Cdd:PRK15370 381 NLPENLPAALQIMQASRNNLVRLPESlphFRGEGPQPTRIIVEYNPFSER 430
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 144-363 1.26e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 49.66  E-value: 1.26e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506041  144 RVLEKLPGLVFLYMEKNQLEE-----VPSALPRN--LEQLRLSQNHISRIPPGVFSKLEN-LLLLDLQHNRLSDGVFKPD 215
Cdd:cd00116  17 ELLPKLLCLQVLRLEGNTLGEeaakaLASALRPQpsLKELCLSLNETGRIPRGLQSLLQGlTKGCGLQELDLSDNALGPD 96

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506041  216 TFHGLKNLMQ------LNLAHNILRKMPPR--------VPTAIHQLYLDSNKIE--------------------TIPNGY 261
Cdd:cd00116  97 GCGVLESLLRssslqeLKLNNNGLGDRGLRllakglkdLPPALEKLVLGRNRLEgascealakalranrdlkelNLANNG 176

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506041  262 ------------FKSFPNLAFIRLNYNKLTDRG-------LPKNSFnisnLLVLHLSHNRISSVPA---------INNRL 313
Cdd:cd00116 177 igdagiralaegLKANCNLEVLDLNNNGLTDEGasalaetLASLKS----LEVLNLGDNNLTDAGAaalasallsPNISL 252

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 4506041  314 EHLYLNNNSIEkingtqicpndLVAFHDFSSDLENVPHLRYLRLDGNYLK 363
Cdd:cd00116 253 LTLSLSCNDIT-----------DDGAKDLAEVLAEKESLLELDLRGNKFG 291
LRRNT smart00013
Leucine rich repeat N-terminal domain;
72-107 2.38e-06

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 43.85  E-value: 2.38e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 4506041      72 DCPRECYCPPdfpSALYCDSRNLRKVPVIPPRIHYL 107
Cdd:smart00013   1 ACPAPCNCSG---TAVDCSGRGLTEVPLDLPPDTTL 33
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 102-370 2.95e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 49.46  E-value: 2.95e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506041   102 PRIHYLYLQNNFIT-ELPVESFQNATGLRWINLDNNRIRKIDQRvlEKLPGLVFLYMEKNQLE-EVPSALP--RNLEQLR 177
Cdd:PLN00113  93 PYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSNNNFTGSIPR--GSIPNLETLDLSNNMLSgEIPNDIGsfSSLKVLD 170

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506041   178 LSQNHISRIPPGVFSKLENLLLLDLQHNRLSDGVfkPDTFHGLKNLMQLNLAHNILRKmppRVPTAIHQL----YLD--- 250
Cdd:PLN00113 171 LGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQI--PRELGQMKSLKWIYLGYNNLSG---EIPYEIGGLtslnHLDlvy 245

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506041   251 SNKIETIPNGyFKSFPNLAFIRLNYNKLTDRgLPKNSFNISNLLVLHLSHNRIS-SVPAINNRLE-----HLYlNNNSIE 324
Cdd:PLN00113 246 NNLTGPIPSS-LGNLKNLQYLFLYQNKLSGP-IPPSIFSLQKLISLDLSDNSLSgEIPELVIQLQnleilHLF-SNNFTG 322

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 4506041   325 KINGTqicpndlvafhdfssdLENVPHLRYLRLDGNYLKPPIPLDL 370
Cdd:PLN00113 323 KIPVA----------------LTSLPRLQVLQLWSNKFSGEIPKNL 352
LRR_8 pfam13855
Leucine rich repeat;
247-303 1.80e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.13  E-value: 1.80e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 4506041    247 LYLDSNKIETIPNGYFKSFPNLAFIRLNYNKLTdrGLPKNSF-NISNLLVLHLSHNRI 303
Cdd:pfam13855   6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLT--TLSPGAFsGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
291-362 3.61e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.97  E-value: 3.61e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4506041    291 SNLLVLHLSHNRISSVPAI----NNRLEHLYLNNNSIEKINGtqicpndlVAFHDFssdlenvPHLRYLRLDGNYL 362
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGafkgLSNLKVLDLSNNLLTTLSP--------GAFSGL-------PSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
171-231 2.43e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.66  E-value: 2.43e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4506041    171 RNLEQLRLSQNHISRIPPGVFSKLENLLLLDLQHNRLSdgVFKPDTFHGLKNLMQLNLAHN 231
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLT--TLSPGAFSGLPSLRYLDLSGN 59
LRR_8 pfam13855
Leucine rich repeat;
266-323 2.82e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.66  E-value: 2.82e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4506041    266 PNLAFIRLNYNKLTDrgLPKNSF-NISNLLVLHLSHNRISSVPAI----NNRLEHLYLNNNSI 323
Cdd:pfam13855   1 PNLRSLDLSNNRLTS--LDDGAFkGLSNLKVLDLSNNLLTTLSPGafsgLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
203-254 8.40e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.12  E-value: 8.40e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 4506041    203 QHNRLSdgVFKPDTFHGLKNLMQLNLAHNILRKMPPRV---PTAIHQLYLDSNKI 254
Cdd:pfam13855   9 SNNRLT--SLDDGAFKGLSNLKVLDLSNNLLTTLSPGAfsgLPSLRYLDLSGNRL 61
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 72-102 9.41e-04

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 36.45  E-value: 9.41e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 4506041     72 DCPRECYCPPdfpSALYCDSRNLRKVPVIPP 102
Cdd:pfam01462   1 ACPVPCHCSA---TVVNCSDRGLTAVPRDLP 28
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 111-377 1.16e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 40.99  E-value: 1.16e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506041   111 NNFITELPVeSFQNATGLRWINLDNNRIRKIDQRVLEKLPGLVFLYMEKNQLE-EVPSALP--RNLEQLRLSQNHISRIP 187
Cdd:PLN00113 246 NNLTGPIPS-SLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSgEIPELVIqlQNLEILHLFSNNFTGKI 324

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506041   188 PGVFSKLENLLLLDLQHNRLSDGVfkPDTFHGLKNLMQLNLAHNILR-KMPPRVPTAIH--QLYLDSNKIET-IP----- 258
Cdd:PLN00113 325 PVALTSLPRLQVLQLWSNKFSGEI--PKNLGKHNNLTVLDLSTNNLTgEIPEGLCSSGNlfKLILFSNSLEGeIPkslga 402

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506041   259 -----------NGY-------FKSFPNLAFIRLNYNKLTDRgLPKNSFNISNLLVLHLSHNRIS-SVPAI--NNRLEHLY 317
Cdd:PLN00113 403 crslrrvrlqdNSFsgelpseFTKLPLVYFLDISNNNLQGR-INSRKWDMPSLQMLSLARNKFFgGLPDSfgSKRLENLD 481

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506041   318 LNNNsieKINGTqiCPNDLVAFhdfssdlenvPHLRYLRLDGNYLKPPIPLDLMMCFRLL 377
Cdd:PLN00113 482 LSRN---QFSGA--VPRKLGSL----------SELMQLKLSENKLSGEIPDELSSCKKLV 526
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 292-328 1.61e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.07  E-value: 1.61e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 4506041    292 NLLVLHLSHNRISSVPAINN--RLEHLYL-NNNSIEKING 328
Cdd:pfam12799   2 NLEVLDLSNNQITDIPPLAKlpNLETLDLsGNNKITDLSD 41
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
87-256 2.62e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 39.53  E-value: 2.62e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506041   87 LYCDSRNLRKVPVIP--PRIHYLYLQNNFITELPVESfqNATGLRWINLDNNRIRKIDQRVLEKLPGLVFLYMEKNQLEE 164
Cdd:COG4886 233 LDLSNNQLTDLPELGnlTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNL 310

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506041  165 VPSALPRNLEQLRLSQNHISRIPPGVFSKLENLLLLDLQHNRLSDGVFKPDTFHGLKNLMQLNLAHNILRKMPPRVPTAI 244
Cdd:COG4886 311 LELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLL 390

                       170
                ....*....|..
gi 4506041  245 HQLYLDSNKIET 256
Cdd:COG4886 391 LLLLTTTAGVLL 402
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 239-323 4.72e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 39.00  E-value: 4.72e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506041  239 RVPTAIHQLYLDSNKIETipNG------YFKSFPNLAFIRLNYNKLTDRG---LPKNSFNISNLLVLHLSHNRISSVPAI 309
Cdd:COG5238 261 KNNTTVETLYLSGNQIGA--EGaialakALQGNTTLTSLDLSVNRIGDEGaiaLAEGLQGNKTLHTLNLAYNGIGAQGAI 338

                        90       100
                ....*....|....*....|..
gi 4506041  310 --------NNRLEHLYLNNNSI 323
Cdd:COG5238 339 alakalqeNTTLHSLDLSDNQI 360
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 94-318 6.41e-03

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 38.70  E-value: 6.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506041     94 LRKVPVIPPRIHYLYLQNNFITELPvesfqnaTGLRWINLDN-----NRIRKIDQRV--LEKL-----PGLVFLYMEKNQ 161
Cdd:PLN03210  717 LKSFPDISTNISWLDLDETAIEEFP-------SNLRLENLDElilceMKSEKLWERVqpLTPLmtmlsPSLTRLFLSDIP 789

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506041    162 -LEEVPSALPR--NLEQLRLSQ-NHISRIPPGVfsklenlllldlqhnrlsdgvfkpdtfhGLKNLMQLNLAHNILRKMP 237
Cdd:PLN03210  790 sLVELPSSIQNlhKLEHLEIENcINLETLPTGI----------------------------NLESLESLDLSGCSRLRTF 841

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506041    238 PRVPTAIHQLYLDSNKIETIPnGYFKSFPNLAFIRLNynklTDRGLPKNSFNISNLLVL------------HLSHNRISS 305
Cdd:PLN03210  842 PDISTNISDLNLSRTGIEEVP-WWIEKFSNLSFLDMN----GCNNLQRVSLNISKLKHLetvdfsdcgaltEASWNGSPS 916

                         250
                  ....*....|...
gi 4506041    306 VPAINNRLEHLYL 318
Cdd:PLN03210  917 EVAMATDNIHSKL 929
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH