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Conserved domains on  [gi|110832843|ref|NP_003176|]
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transcription initiation factor TFIID subunit 4 [Homo sapiens]

Protein Classification

TAFH and TAF4 domain-containing protein( domain architecture ID 11167152)

TAFH and TAF4 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TAF4 pfam05236
Transcription initiation factor TFIID component TAF4 family; This region of similarity is ...
 834-1082 2.38e-119

Transcription initiation factor TFIID component TAF4 family; This region of similarity is found in Transcription initiation factor TFIID component TAF4.


:

Pssm-ID: 461598 [Multi-domain]  Cd Length: 264  Bit Score: 367.75  E-value: 2.38e-119
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110832843   834 INDVASMAGVNLSEESARIL-----ATNSELVGTLTRSCKDETFLLQAPLQRRILEIGKKHGITELHPDVVSYVSHATQQ 908
Cdd:pfam05236    1 LNDVLAMAGVNLREEEERLLssqeaSTNSEAVGTVVRSCKDEPFLNPYPLQRKILEIAKKNGLKEIDPDVLELLSHACEE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110832843   909 RLQNLVEKISETAQQKNFSYKDDDRYEQASDVRAQLKFFEQLDQIEKQRKDEQEREILMRAAKSRSRQEDPEQLRLKQKA 988
Cdd:pfam05236   81 RLRNLLEKLIVISRHRRDGEKTDHRYEQTSDVRKQLKFLAQKDKEEEERRVAEEREGLLKAAKSRSNQEDPEQLKLKQEA 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110832843   989 KEMQQQELAQMRQRDANLTALAAIGPRKKRKVD----CPGPGSGAEGSGPGSVVPGSSGVGTPRQFT------RQRITRV 1058
Cdd:pfam05236  161 KEMQKEEDEKMRHRAANLTALAAIGPRKKKYSWmsssASGSGGGGSGSSKPSSSSGSSSKGTSQTQSsaisreARRIKRV 240

                          250       260
                   ....*....|....*....|....
gi 110832843  1059 NLRDLIFCLENERETSHSLLLYKA 1082
Cdd:pfam05236  241 TLRDLLFALEQEREGSRSALLYGY 264
TAFH pfam07531
NHR1 homology to TAF; This corresponds to the region NHR1 that is conserved between the ...
 592-675 1.13e-40

NHR1 homology to TAF; This corresponds to the region NHR1 that is conserved between the product of the nervy gene in Drosophila and the human mtg8b protein, which is hypothesized to be a transcription factor.


:

Pssm-ID: 462195  Cd Length: 90  Bit Score: 144.33  E-value: 1.13e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110832843   592 NVKKCKNFLSTLIKLAssGKQSTETAANVKELVQNLLDGKIEAEDFTSRLYRELNSSPQPYLVPFLKRSLPALRQLTPDS 671
Cdd:pfam07531    1 NVKKCKNFLSTLIKLA--GEQSPETGENVKELVQGLLNGKIEPEEFTSKLQEELNSSPQPYLVPFLKKSLPALRQELLNS 78


                   ....
gi 110832843   672 AAFI 675
Cdd:pfam07531   79 ARFI 82
 
Name Accession Description Interval E-value
TAF4 pfam05236
Transcription initiation factor TFIID component TAF4 family; This region of similarity is ...
 834-1082 2.38e-119

Transcription initiation factor TFIID component TAF4 family; This region of similarity is found in Transcription initiation factor TFIID component TAF4.


Pssm-ID: 461598 [Multi-domain]  Cd Length: 264  Bit Score: 367.75  E-value: 2.38e-119
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110832843   834 INDVASMAGVNLSEESARIL-----ATNSELVGTLTRSCKDETFLLQAPLQRRILEIGKKHGITELHPDVVSYVSHATQQ 908
Cdd:pfam05236    1 LNDVLAMAGVNLREEEERLLssqeaSTNSEAVGTVVRSCKDEPFLNPYPLQRKILEIAKKNGLKEIDPDVLELLSHACEE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110832843   909 RLQNLVEKISETAQQKNFSYKDDDRYEQASDVRAQLKFFEQLDQIEKQRKDEQEREILMRAAKSRSRQEDPEQLRLKQKA 988
Cdd:pfam05236   81 RLRNLLEKLIVISRHRRDGEKTDHRYEQTSDVRKQLKFLAQKDKEEEERRVAEEREGLLKAAKSRSNQEDPEQLKLKQEA 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110832843   989 KEMQQQELAQMRQRDANLTALAAIGPRKKRKVD----CPGPGSGAEGSGPGSVVPGSSGVGTPRQFT------RQRITRV 1058
Cdd:pfam05236  161 KEMQKEEDEKMRHRAANLTALAAIGPRKKKYSWmsssASGSGGGGSGSSKPSSSSGSSSKGTSQTQSsaisreARRIKRV 240

                          250       260
                   ....*....|....*....|....
gi 110832843  1059 NLRDLIFCLENERETSHSLLLYKA 1082
Cdd:pfam05236  241 TLRDLLFALEQEREGSRSALLYGY 264
TAFH pfam07531
NHR1 homology to TAF; This corresponds to the region NHR1 that is conserved between the ...
 592-675 1.13e-40

NHR1 homology to TAF; This corresponds to the region NHR1 that is conserved between the product of the nervy gene in Drosophila and the human mtg8b protein, which is hypothesized to be a transcription factor.


Pssm-ID: 462195  Cd Length: 90  Bit Score: 144.33  E-value: 1.13e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110832843   592 NVKKCKNFLSTLIKLAssGKQSTETAANVKELVQNLLDGKIEAEDFTSRLYRELNSSPQPYLVPFLKRSLPALRQLTPDS 671
Cdd:pfam07531    1 NVKKCKNFLSTLIKLA--GEQSPETGENVKELVQGLLNGKIEPEEFTSKLQEELNSSPQPYLVPFLKKSLPALRQELLNS 78


                   ....
gi 110832843   672 AAFI 675
Cdd:pfam07531   79 ARFI 82
HFD_TAF4 cd08045
histone-fold domain found in transcription initiation factor TFIID subunit 4 (TAF4) and ...
 869-968 2.70e-37

histone-fold domain found in transcription initiation factor TFIID subunit 4 (TAF4) and similar proteins; TAF4, also called TATA Binding Protein (TBP) associated factor 4, RNA polymerase II TBP-associated factor subunit C, TBP-associated factor 4, transcription initiation factor TFIID 130 kDa subunit (TAF(II)130, TAFII-130, TAFII130), or transcription initiation factor TFIID 135 kDa subunit (TAF(II)135, TAFII-135, TAFII135), is a component of the TFIID complex that is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). TFIID is one of the general transcription factors required for accurate and regulated initiation by RNA polymerase II. It plays a central role in mediating promoter responses to various activators and repressors. TAF4 potentiates transcriptional activation by the AF-2S of retinoic acid, vitamin D3 and thyroid hormone. TAF4 also acts as a component of the TFTC-HAT complex and some MLL1/MLL complexes. TAF4 interacts with ATF7 and the interaction inhibits ATF7-mediated transactivation.


Pssm-ID: 467027 [Multi-domain]  Cd Length: 100  Bit Score: 135.05  E-value: 2.70e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110832843  869 DETFLLQAPLQRRILEIGKKHGITELHPDVVSYVSHATQQRLQNLVEKISETAQQKNFSYKDDDRYEQASDVRAQLKFFE 948
Cdd:cd08045     1 EESFLNPPPLQKKIQKIAKKHGLKEVSPDVLSLLSLAVQERLRDLLEKLIVASKHRVDSEKPDYRYEVTSDVRRQLKALE 80

                          90       100
                  ....*....|....*....|
gi 110832843  949 QLDQIEKQRKDEQEREILMR 968
Cdd:cd08045    81 RLEREEEERRREEERERLLR 100
TAFH smart00549
TAF homology; Domain in Drosophila nervy, CBFA2T1, human TAF105, human TAF130, and Drosophila ...
 592-675 9.15e-33

TAF homology; Domain in Drosophila nervy, CBFA2T1, human TAF105, human TAF130, and Drosophila TAF110. Also known as nervy homology region 1 (NHR1).


Pssm-ID: 197785 [Multi-domain]  Cd Length: 92  Bit Score: 122.18  E-value: 9.15e-33
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110832843    592 NVKKCKNFLSTLIKLASSGKQsTETAANVKELVQNLLDGKIEAEDFTSRLYRELNSSPQPYLVPFLKRSLPALRQLTPDS 671
Cdd:smart00549    1 NVSKCKRFLTTLIQLSNDISQ-PEVAERVRTLVLGLVNGTITAEEFTSRLQEALNSPLQPYLIPFLKNSLPLLRRELLHC 79


                    ....
gi 110832843    672 AAFI 675
Cdd:smart00549   80 ARLI 83
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 853-1011 1.18e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 46.20  E-value: 1.18e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110832843   853 LATNSELVGTLTRSCKDETFLLQApLQRRILEIgkKHGITELHPDVVSYvshatQQRLQNLVEKISETAQQKNFsYKDDD 932
Cdd:TIGR02168  241 LEELQEELKEAEEELEELTAELQE-LEEKLEEL--RLEVSELEEEIEEL-----QKELYALANEISRLEQQKQI-LRERL 311

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110832843   933 RYEQASDVRAQlkffEQLDQiEKQRKDEQEREILMRAAKSRSRQEDPEQLRLKQKAKEMQQQEL-AQMRQRDANLTALAA 1011
Cdd:TIGR02168  312 ANLERQLEELE----AQLEE-LESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELeSRLEELEEQLETLRS 386
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 904-1011 1.09e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 43.00  E-value: 1.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110832843  904 HATQQRLQNLVEKISETAQQKNFsykDDDRYEQASDVRAQLKffEQLDQIEKQRKDEQEREIlmrAAKSRSRQEDPEQLR 983
Cdd:COG1196   284 EEAQAEEYELLAELARLEQDIAR---LEERRRELEERLEELE--EELAELEEELEELEEELE---ELEEELEEAEEELEE 355

                          90       100
                  ....*....|....*....|....*...
gi 110832843  984 LKQKAKEMQQQELAQMRQRDANLTALAA 1011
Cdd:COG1196   356 AEAELAEAEEALLEAEAELAEAEEELEE 383
 
Name Accession Description Interval E-value
TAF4 pfam05236
Transcription initiation factor TFIID component TAF4 family; This region of similarity is ...
 834-1082 2.38e-119

Transcription initiation factor TFIID component TAF4 family; This region of similarity is found in Transcription initiation factor TFIID component TAF4.


Pssm-ID: 461598 [Multi-domain]  Cd Length: 264  Bit Score: 367.75  E-value: 2.38e-119
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110832843   834 INDVASMAGVNLSEESARIL-----ATNSELVGTLTRSCKDETFLLQAPLQRRILEIGKKHGITELHPDVVSYVSHATQQ 908
Cdd:pfam05236    1 LNDVLAMAGVNLREEEERLLssqeaSTNSEAVGTVVRSCKDEPFLNPYPLQRKILEIAKKNGLKEIDPDVLELLSHACEE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110832843   909 RLQNLVEKISETAQQKNFSYKDDDRYEQASDVRAQLKFFEQLDQIEKQRKDEQEREILMRAAKSRSRQEDPEQLRLKQKA 988
Cdd:pfam05236   81 RLRNLLEKLIVISRHRRDGEKTDHRYEQTSDVRKQLKFLAQKDKEEEERRVAEEREGLLKAAKSRSNQEDPEQLKLKQEA 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110832843   989 KEMQQQELAQMRQRDANLTALAAIGPRKKRKVD----CPGPGSGAEGSGPGSVVPGSSGVGTPRQFT------RQRITRV 1058
Cdd:pfam05236  161 KEMQKEEDEKMRHRAANLTALAAIGPRKKKYSWmsssASGSGGGGSGSSKPSSSSGSSSKGTSQTQSsaisreARRIKRV 240

                          250       260
                   ....*....|....*....|....
gi 110832843  1059 NLRDLIFCLENERETSHSLLLYKA 1082
Cdd:pfam05236  241 TLRDLLFALEQEREGSRSALLYGY 264
TAFH pfam07531
NHR1 homology to TAF; This corresponds to the region NHR1 that is conserved between the ...
 592-675 1.13e-40

NHR1 homology to TAF; This corresponds to the region NHR1 that is conserved between the product of the nervy gene in Drosophila and the human mtg8b protein, which is hypothesized to be a transcription factor.


Pssm-ID: 462195  Cd Length: 90  Bit Score: 144.33  E-value: 1.13e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110832843   592 NVKKCKNFLSTLIKLAssGKQSTETAANVKELVQNLLDGKIEAEDFTSRLYRELNSSPQPYLVPFLKRSLPALRQLTPDS 671
Cdd:pfam07531    1 NVKKCKNFLSTLIKLA--GEQSPETGENVKELVQGLLNGKIEPEEFTSKLQEELNSSPQPYLVPFLKKSLPALRQELLNS 78


                   ....
gi 110832843   672 AAFI 675
Cdd:pfam07531   79 ARFI 82
HFD_TAF4 cd08045
histone-fold domain found in transcription initiation factor TFIID subunit 4 (TAF4) and ...
 869-968 2.70e-37

histone-fold domain found in transcription initiation factor TFIID subunit 4 (TAF4) and similar proteins; TAF4, also called TATA Binding Protein (TBP) associated factor 4, RNA polymerase II TBP-associated factor subunit C, TBP-associated factor 4, transcription initiation factor TFIID 130 kDa subunit (TAF(II)130, TAFII-130, TAFII130), or transcription initiation factor TFIID 135 kDa subunit (TAF(II)135, TAFII-135, TAFII135), is a component of the TFIID complex that is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). TFIID is one of the general transcription factors required for accurate and regulated initiation by RNA polymerase II. It plays a central role in mediating promoter responses to various activators and repressors. TAF4 potentiates transcriptional activation by the AF-2S of retinoic acid, vitamin D3 and thyroid hormone. TAF4 also acts as a component of the TFTC-HAT complex and some MLL1/MLL complexes. TAF4 interacts with ATF7 and the interaction inhibits ATF7-mediated transactivation.


Pssm-ID: 467027 [Multi-domain]  Cd Length: 100  Bit Score: 135.05  E-value: 2.70e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110832843  869 DETFLLQAPLQRRILEIGKKHGITELHPDVVSYVSHATQQRLQNLVEKISETAQQKNFSYKDDDRYEQASDVRAQLKFFE 948
Cdd:cd08045     1 EESFLNPPPLQKKIQKIAKKHGLKEVSPDVLSLLSLAVQERLRDLLEKLIVASKHRVDSEKPDYRYEVTSDVRRQLKALE 80

                          90       100
                  ....*....|....*....|
gi 110832843  949 QLDQIEKQRKDEQEREILMR 968
Cdd:cd08045    81 RLEREEEERRREEERERLLR 100
TAFH smart00549
TAF homology; Domain in Drosophila nervy, CBFA2T1, human TAF105, human TAF130, and Drosophila ...
 592-675 9.15e-33

TAF homology; Domain in Drosophila nervy, CBFA2T1, human TAF105, human TAF130, and Drosophila TAF110. Also known as nervy homology region 1 (NHR1).


Pssm-ID: 197785 [Multi-domain]  Cd Length: 92  Bit Score: 122.18  E-value: 9.15e-33
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110832843    592 NVKKCKNFLSTLIKLASSGKQsTETAANVKELVQNLLDGKIEAEDFTSRLYRELNSSPQPYLVPFLKRSLPALRQLTPDS 671
Cdd:smart00549    1 NVSKCKRFLTTLIQLSNDISQ-PEVAERVRTLVLGLVNGTITAEEFTSRLQEALNSPLQPYLIPFLKNSLPLLRRELLHC 79


                    ....
gi 110832843    672 AAFI 675
Cdd:smart00549   80 ARLI 83
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
 907-1002 8.71e-05

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 464007 [Multi-domain]  Cd Length: 341  Bit Score: 46.07  E-value: 8.71e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110832843   907 QQRLQNLVEKISETAQQKnfsykdDDRYEqasdVRAQLkFFEQLDQIEKQR-KDEQEREILMRAAKSRSRQEdpeQLRLK 985
Cdd:pfam13868  183 EREIARLRAQQEKAQDEK------AERDE----LRAKL-YQEEQERKERQKeREEAEKKARQRQELQQAREE---QIELK 248

                           90
                   ....*....|....*..
gi 110832843   986 QKAKEMQQQELAQMRQR 1002
Cdd:pfam13868  249 ERRLAEEAEREEEEFER 265
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 853-1011 1.18e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 46.20  E-value: 1.18e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110832843   853 LATNSELVGTLTRSCKDETFLLQApLQRRILEIgkKHGITELHPDVVSYvshatQQRLQNLVEKISETAQQKNFsYKDDD 932
Cdd:TIGR02168  241 LEELQEELKEAEEELEELTAELQE-LEEKLEEL--RLEVSELEEEIEEL-----QKELYALANEISRLEQQKQI-LRERL 311

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110832843   933 RYEQASDVRAQlkffEQLDQiEKQRKDEQEREILMRAAKSRSRQEDPEQLRLKQKAKEMQQQEL-AQMRQRDANLTALAA 1011
Cdd:TIGR02168  312 ANLERQLEELE----AQLEE-LESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELeSRLEELEEQLETLRS 386
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 904-1011 1.09e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 43.00  E-value: 1.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110832843  904 HATQQRLQNLVEKISETAQQKNFsykDDDRYEQASDVRAQLKffEQLDQIEKQRKDEQEREIlmrAAKSRSRQEDPEQLR 983
Cdd:COG1196   284 EEAQAEEYELLAELARLEQDIAR---LEERRRELEERLEELE--EELAELEEELEELEEELE---ELEEELEEAEEELEE 355

                          90       100
                  ....*....|....*....|....*...
gi 110832843  984 LKQKAKEMQQQELAQMRQRDANLTALAA 1011
Cdd:COG1196   356 AEAELAEAEEALLEAEAELAEAEEELEE 383
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
 907-1002 1.24e-03

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 464007 [Multi-domain]  Cd Length: 341  Bit Score: 42.21  E-value: 1.24e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110832843   907 QQRLQNLVEKISETAQ--QKNFSYKDDDRYEQASDVRAQLKFFEQLDQIEKQRKD------EQEREILMRAA-----KSR 973
Cdd:pfam13868   87 QKRQEEYEEKLQEREQmdEIVERIQEEDQAEAEEKLEKQRQLREEIDEFNEEQAEwkelekEEEREEDERILeylkeKAE 166

                           90       100
                   ....*....|....*....|....*....
gi 110832843   974 SRQEDPEQLRLKQKAKEMQQQELAQMRQR 1002
Cdd:pfam13868  167 REEEREAEREEIEEEKEREIARLRAQQEK 195
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
 904-1002 2.97e-03

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 464007 [Multi-domain]  Cd Length: 341  Bit Score: 41.06  E-value: 2.97e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110832843   904 HATQQRLQNLVEKISEtaQQKNFSYKDDDRyEQASDVRAqLKFFEQLDQIEKQRKDEQEREILMRA----------AKSR 973
Cdd:pfam13868  122 LEKQRQLREEIDEFNE--EQAEWKELEKEE-EREEDERI-LEYLKEKAEREEEREAEREEIEEEKEreiarlraqqEKAQ 197

                           90       100       110
                   ....*....|....*....|....*....|...
gi 110832843   974 SRQEDPEQLRLK----QKAKEMQQQELAQMRQR 1002
Cdd:pfam13868  198 DEKAERDELRAKlyqeEQERKERQKEREEAEKK 230
RRP36 pfam06102
rRNA biogenesis protein RRP36; RRP36 is involved in the early processing steps of the pre-rRNA.
 913-993 6.90e-03

rRNA biogenesis protein RRP36; RRP36 is involved in the early processing steps of the pre-rRNA.


Pssm-ID: 461829 [Multi-domain]  Cd Length: 158  Bit Score: 38.31  E-value: 6.90e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110832843   913 LVEKISETAQQKNFSYKDDDRYEQASDVRAQLKffeqldqiekQRKDEQEREILMRA-------AKSRSRQEDPEQLRLK 985
Cdd:pfam06102   38 LSGEFDEDKFRKNYGFLDEYRKKEIEELKKQLK----------KTKDPEEKEELKRTlqsmesrLKAKKRKDREREVLKE 107


                   ....*...
gi 110832843   986 QKAKEMQQ 993
Cdd:pfam06102  108 HKKEEKEK 115
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
872-1011 8.15e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 40.14  E-value: 8.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110832843  872 FLLQAPLQRRILEIGKKHG----------------ITELHPDVVSYvsHATQQRLQNLVEKISETAQQKNFSYKDDDRYE 935
Cdd:COG4717    45 AMLLERLEKEADELFKPQGrkpelnlkelkeleeeLKEAEEKEEEY--AELQEELEELEEELEELEAELEELREELEKLE 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110832843  936 QASDVRAQLKFFEQL--------DQIEKQRKDEQEREILMRAAKSRSRQEDPEQLRLKQKAKEMQQQELAQMRQRDANLT 1007
Cdd:COG4717   123 KLLQLLPLYQELEALeaelaelpERLEELEERLEELRELEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELE 202


                  ....
gi 110832843 1008 ALAA 1011
Cdd:COG4717   203 ELQQ 206
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
 907-1002 8.45e-03

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 464007 [Multi-domain]  Cd Length: 341  Bit Score: 39.52  E-value: 8.45e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110832843   907 QQRLQNLVEKisETAQQKnfsYKDDDRyEQASDVRAQLKFFEQLDQIEKQRKDEQE----REILM-----RAAKSRSRQE 977
Cdd:pfam13868  239 QAREEQIELK--ERRLAE---EAEREE-EEFERMLRKQAEDEEIEQEEAEKRRMKRlehrRELEKqieerEEQRAAEREE 312

                           90       100
                   ....*....|....*....|....*
gi 110832843   978 DPEQLRLKQKAKEMQQQELAQMRQR 1002
Cdd:pfam13868  313 ELEEGERLREEEAERRERIEEERQK 337
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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