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tubulin-specific chaperone E isoform a [Homo sapiens]
CAP_GLY and Ubl_TBCE domain-containing protein( domain architecture ID 13651372)
protein containing domains CAP_GLY, PPP1R42, and Ubl_TBCE
List of domain hits
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Name | Accession | Description | Interval | E-value | ||||
Ubl_TBCE | cd17044 | ubiquitin-like (Ubl) domain found in tubulin-folding cofactor E (TBCE) and similar proteins; ... |
444-526 | 1.06e-34 | ||||
ubiquitin-like (Ubl) domain found in tubulin-folding cofactor E (TBCE) and similar proteins; TBCE, also termed tubulin-specific chaperone E, is a tubulin polymerizing protein involved in the second step of the tubulin folding pathway through cooperating in tubulin heterodimer dissociation both in vivo and in vitro. It may also be implicated in the maintenance of the neuronal microtubule network. Mutations in TBCE gene cause hypoparathyroidism, mental retardation and facial dysmorphism. TBCE contains an N-terminal cytoskeleton-associated protein with glycine-rich segment (CAP-Gly) domain, a leucine-rich repeat protein-protein interaction domain followed by leucine-rich repeat (LRR) domains, and a C-terminal ubiquitin-like (Ubl) domain. Ubiquitin is a protein modifier in eukaryotes that is involved in various cellular processes. : Pssm-ID: 340564 Cd Length: 83 Bit Score: 125.39 E-value: 1.06e-34
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CAP_GLY | pfam01302 | CAP-Gly domain; Cytoskeleton-associated proteins (CAPs) are involved in the organization of ... |
10-75 | 1.09e-24 | ||||
CAP-Gly domain; Cytoskeleton-associated proteins (CAPs) are involved in the organization of microtubules and transportation of vesicles and organelles along the cytoskeletal network. A conserved motif, CAP-Gly, has been identified in a number of CAPs, including CLIP-170 and dynactins. The crystal structure of Caenorhabditis elegans F53F4.3 protein CAP-Gly domain was recently solved. The domain contains three beta-strands. The most conserved sequence, GKNDG, is located in two consecutive sharp turns on the surface, forming the entrance to a groove. : Pssm-ID: 460154 [Multi-domain] Cd Length: 65 Bit Score: 97.09 E-value: 1.09e-24
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LRR | COG4886 | Leucine-rich repeat (LRR) protein [Transcription]; |
113-345 | 6.98e-16 | ||||
Leucine-rich repeat (LRR) protein [Transcription]; : Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 79.59 E-value: 6.98e-16
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Name | Accession | Description | Interval | E-value | ||||
Ubl_TBCE | cd17044 | ubiquitin-like (Ubl) domain found in tubulin-folding cofactor E (TBCE) and similar proteins; ... |
444-526 | 1.06e-34 | ||||
ubiquitin-like (Ubl) domain found in tubulin-folding cofactor E (TBCE) and similar proteins; TBCE, also termed tubulin-specific chaperone E, is a tubulin polymerizing protein involved in the second step of the tubulin folding pathway through cooperating in tubulin heterodimer dissociation both in vivo and in vitro. It may also be implicated in the maintenance of the neuronal microtubule network. Mutations in TBCE gene cause hypoparathyroidism, mental retardation and facial dysmorphism. TBCE contains an N-terminal cytoskeleton-associated protein with glycine-rich segment (CAP-Gly) domain, a leucine-rich repeat protein-protein interaction domain followed by leucine-rich repeat (LRR) domains, and a C-terminal ubiquitin-like (Ubl) domain. Ubiquitin is a protein modifier in eukaryotes that is involved in various cellular processes. Pssm-ID: 340564 Cd Length: 83 Bit Score: 125.39 E-value: 1.06e-34
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CAP_GLY | pfam01302 | CAP-Gly domain; Cytoskeleton-associated proteins (CAPs) are involved in the organization of ... |
10-75 | 1.09e-24 | ||||
CAP-Gly domain; Cytoskeleton-associated proteins (CAPs) are involved in the organization of microtubules and transportation of vesicles and organelles along the cytoskeletal network. A conserved motif, CAP-Gly, has been identified in a number of CAPs, including CLIP-170 and dynactins. The crystal structure of Caenorhabditis elegans F53F4.3 protein CAP-Gly domain was recently solved. The domain contains three beta-strands. The most conserved sequence, GKNDG, is located in two consecutive sharp turns on the surface, forming the entrance to a groove. Pssm-ID: 460154 [Multi-domain] Cd Length: 65 Bit Score: 97.09 E-value: 1.09e-24
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CAP_GLY | smart01052 | Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and ... |
10-75 | 2.89e-24 | ||||
Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network; A conserved motif, CAP-Gly, has been identified in a number of CAPs, including CLIP-170 and dynactins. The crystal structure of Caenorhabditis elegans F53F4.3 protein CAP-Gly domain was recently solved. The domain contains three beta-strands. The most conserved sequence, GKNDG, is located in two consecutive sharp turns on the surface, forming the entrance to a groove. Pssm-ID: 214997 [Multi-domain] Cd Length: 68 Bit Score: 95.73 E-value: 2.89e-24
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LRR | COG4886 | Leucine-rich repeat (LRR) protein [Transcription]; |
113-345 | 6.98e-16 | ||||
Leucine-rich repeat (LRR) protein [Transcription]; Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 79.59 E-value: 6.98e-16
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PPP1R42 | cd21340 | protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
152-379 | 1.38e-10 | ||||
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation. Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 61.34 E-value: 1.38e-10
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NIP100 | COG5244 | Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle ... |
10-76 | 7.67e-09 | ||||
Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle control, cell division, chromosome partitioning]; Pssm-ID: 227569 [Multi-domain] Cd Length: 669 Bit Score: 58.16 E-value: 7.67e-09
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PLN00113 | PLN00113 | leucine-rich repeat receptor-like protein kinase; Provisional |
152-368 | 2.99e-05 | ||||
leucine-rich repeat receptor-like protein kinase; Provisional Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 46.76 E-value: 2.99e-05
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LRR_9 | pfam14580 | Leucine-rich repeat; |
233-396 | 3.55e-05 | ||||
Leucine-rich repeat; Pssm-ID: 405295 [Multi-domain] Cd Length: 175 Bit Score: 44.37 E-value: 3.55e-05
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Ubiquitin_2 | pfam14560 | Ubiquitin-like domain; This entry contains ubiquitin-like domains. |
456-525 | 2.89e-04 | ||||
Ubiquitin-like domain; This entry contains ubiquitin-like domains. Pssm-ID: 405277 Cd Length: 83 Bit Score: 39.82 E-value: 2.89e-04
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UBQ | smart00213 | Ubiquitin homologues; Ubiquitin-mediated proteolysis is involved in the regulated turnover of ... |
446-521 | 1.59e-03 | ||||
Ubiquitin homologues; Ubiquitin-mediated proteolysis is involved in the regulated turnover of proteins required for controlling cell cycle progression Pssm-ID: 214563 [Multi-domain] Cd Length: 72 Bit Score: 37.24 E-value: 1.59e-03
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Name | Accession | Description | Interval | E-value | |||||
Ubl_TBCE | cd17044 | ubiquitin-like (Ubl) domain found in tubulin-folding cofactor E (TBCE) and similar proteins; ... |
444-526 | 1.06e-34 | |||||
ubiquitin-like (Ubl) domain found in tubulin-folding cofactor E (TBCE) and similar proteins; TBCE, also termed tubulin-specific chaperone E, is a tubulin polymerizing protein involved in the second step of the tubulin folding pathway through cooperating in tubulin heterodimer dissociation both in vivo and in vitro. It may also be implicated in the maintenance of the neuronal microtubule network. Mutations in TBCE gene cause hypoparathyroidism, mental retardation and facial dysmorphism. TBCE contains an N-terminal cytoskeleton-associated protein with glycine-rich segment (CAP-Gly) domain, a leucine-rich repeat protein-protein interaction domain followed by leucine-rich repeat (LRR) domains, and a C-terminal ubiquitin-like (Ubl) domain. Ubiquitin is a protein modifier in eukaryotes that is involved in various cellular processes. Pssm-ID: 340564 Cd Length: 83 Bit Score: 125.39 E-value: 1.06e-34
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CAP_GLY | pfam01302 | CAP-Gly domain; Cytoskeleton-associated proteins (CAPs) are involved in the organization of ... |
10-75 | 1.09e-24 | |||||
CAP-Gly domain; Cytoskeleton-associated proteins (CAPs) are involved in the organization of microtubules and transportation of vesicles and organelles along the cytoskeletal network. A conserved motif, CAP-Gly, has been identified in a number of CAPs, including CLIP-170 and dynactins. The crystal structure of Caenorhabditis elegans F53F4.3 protein CAP-Gly domain was recently solved. The domain contains three beta-strands. The most conserved sequence, GKNDG, is located in two consecutive sharp turns on the surface, forming the entrance to a groove. Pssm-ID: 460154 [Multi-domain] Cd Length: 65 Bit Score: 97.09 E-value: 1.09e-24
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CAP_GLY | smart01052 | Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and ... |
10-75 | 2.89e-24 | |||||
Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network; A conserved motif, CAP-Gly, has been identified in a number of CAPs, including CLIP-170 and dynactins. The crystal structure of Caenorhabditis elegans F53F4.3 protein CAP-Gly domain was recently solved. The domain contains three beta-strands. The most conserved sequence, GKNDG, is located in two consecutive sharp turns on the surface, forming the entrance to a groove. Pssm-ID: 214997 [Multi-domain] Cd Length: 68 Bit Score: 95.73 E-value: 2.89e-24
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LRR | COG4886 | Leucine-rich repeat (LRR) protein [Transcription]; |
113-345 | 6.98e-16 | |||||
Leucine-rich repeat (LRR) protein [Transcription]; Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 79.59 E-value: 6.98e-16
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LRR | COG4886 | Leucine-rich repeat (LRR) protein [Transcription]; |
124-359 | 2.89e-15 | |||||
Leucine-rich repeat (LRR) protein [Transcription]; Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 77.67 E-value: 2.89e-15
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LRR | COG4886 | Leucine-rich repeat (LRR) protein [Transcription]; |
119-369 | 2.01e-14 | |||||
Leucine-rich repeat (LRR) protein [Transcription]; Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 75.36 E-value: 2.01e-14
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PPP1R42 | cd21340 | protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
152-379 | 1.38e-10 | |||||
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation. Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 61.34 E-value: 1.38e-10
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LRR | COG4886 | Leucine-rich repeat (LRR) protein [Transcription]; |
116-343 | 3.14e-10 | |||||
Leucine-rich repeat (LRR) protein [Transcription]; Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 62.26 E-value: 3.14e-10
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NIP100 | COG5244 | Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle ... |
10-76 | 7.67e-09 | |||||
Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle control, cell division, chromosome partitioning]; Pssm-ID: 227569 [Multi-domain] Cd Length: 669 Bit Score: 58.16 E-value: 7.67e-09
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LRR | COG4886 | Leucine-rich repeat (LRR) protein [Transcription]; |
178-377 | 6.61e-06 | |||||
Leucine-rich repeat (LRR) protein [Transcription]; Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 48.39 E-value: 6.61e-06
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LRR_RI | cd00116 | Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
124-267 | 1.88e-05 | |||||
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1). Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 46.58 E-value: 1.88e-05
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PLN00113 | PLN00113 | leucine-rich repeat receptor-like protein kinase; Provisional |
152-368 | 2.99e-05 | |||||
leucine-rich repeat receptor-like protein kinase; Provisional Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 46.76 E-value: 2.99e-05
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LRR_9 | pfam14580 | Leucine-rich repeat; |
233-396 | 3.55e-05 | |||||
Leucine-rich repeat; Pssm-ID: 405295 [Multi-domain] Cd Length: 175 Bit Score: 44.37 E-value: 3.55e-05
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Ubl_ubiquitin_like | cd17039 | ubiquitin-like (Ubl) domain found in ubiquitin and ubiquitin-like Ubl proteins; Ubiquitin-like ... |
448-526 | 7.30e-05 | |||||
ubiquitin-like (Ubl) domain found in ubiquitin and ubiquitin-like Ubl proteins; Ubiquitin-like (Ubl) proteins have a similar ubiquitin (Ub) beta-grasp fold and attach to other proteins in a Ubl manner but with biochemically distinct roles. Ub and Ubl proteins conjugate and deconjugate via ligases and peptidases to covalently modify target polypeptides. Some Ubl domains have adaptor roles in Ub-signaling by mediating protein-protein interaction. Prokaryotic sulfur carrier proteins are Ub-related proteins that can be activated in an ATP-dependent manner. Polyubiquitination signals for a diverse set of cellular events via different isopeptide linkages formed between the C terminus of one ubiquitin (Ub) and the epsilon-amine of K6, K11, K27, K29, K33, K48, or K63 of a second Ub. One of these seven lysine residues (K27, Ub numbering) is conserved in this Ubl_ubiquitin_like family. K27-linked Ub chains are versatile and can be recognized by several downstream receptor proteins. K27 has roles beyond chain linkage, such as in Ubl NEDD8 (which contains many of the same lysines (K6, K11, K27, K33, K48) as Ub) where K27 has a role (other than conjugation) in the mechanism of protein neddylation. Pssm-ID: 340559 [Multi-domain] Cd Length: 68 Bit Score: 41.04 E-value: 7.30e-05
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Ubiquitin_2 | pfam14560 | Ubiquitin-like domain; This entry contains ubiquitin-like domains. |
456-525 | 2.89e-04 | |||||
Ubiquitin-like domain; This entry contains ubiquitin-like domains. Pssm-ID: 405277 Cd Length: 83 Bit Score: 39.82 E-value: 2.89e-04
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LRR_8 | pfam13855 | Leucine rich repeat; |
229-289 | 9.17e-04 | |||||
Leucine rich repeat; Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 37.50 E-value: 9.17e-04
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RNA1 | COG5238 | Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
102-289 | 9.64e-04 | |||||
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis]; Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 41.70 E-value: 9.64e-04
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RNA1 | COG5238 | Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
143-282 | 1.56e-03 | |||||
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis]; Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 40.93 E-value: 1.56e-03
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UBQ | smart00213 | Ubiquitin homologues; Ubiquitin-mediated proteolysis is involved in the regulated turnover of ... |
446-521 | 1.59e-03 | |||||
Ubiquitin homologues; Ubiquitin-mediated proteolysis is involved in the regulated turnover of proteins required for controlling cell cycle progression Pssm-ID: 214563 [Multi-domain] Cd Length: 72 Bit Score: 37.24 E-value: 1.59e-03
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LRR_RI | cd00116 | Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
126-350 | 7.06e-03 | |||||
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1). Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 38.49 E-value: 7.06e-03
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Blast search parameters | ||||
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