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Conserved domains on  [gi|21361151|ref|NP_003251|]
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transducin-like enhancer protein 2 isoform 1 [Homo sapiens]

Protein Classification

TLE_N and WD40 domain-containing protein( domain architecture ID 13692432)

TLE_N and WD40 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TLE_N pfam03920
Groucho/TLE N-terminal Q-rich domain; The N-terminal domain of the Grouch/TLE co-repressor ...
 17-132 7.05e-87

Groucho/TLE N-terminal Q-rich domain; The N-terminal domain of the Grouch/TLE co-repressor proteins are involved in oligomerization.


:

Pssm-ID: 461094  Cd Length: 117  Bit Score: 268.91  E-value: 7.05e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361151    17 FKFSILEICDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSYGLNIEMHKQAEIVKRLSGICAQIIPFLT 96
Cdd:pfam03920   1 FKFTVPETCDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSYGLNIEMHKQTEIAKRLNAICAQVIPFLS 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 21361151    97 QEHQQQVLQAVERAKQVTVGELNSLIGQQLQPLSHH 132
Cdd:pfam03920  81 QEHQQQVAQAVERAKQVTMAELNAIIGQQQQLQAQH 116
WD40 COG2319
WD40 repeat [General function prediction only];
417-741 2.61e-41

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 155.84  E-value: 2.61e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361151 417 PAYSFHVSADGQMQPVPFPSDALVGAGIPRHARQLHTLAHGEVVCAVTISGSTQHVYTGGK-GCVKVWDVGQPgakTPVA 495
Cdd:COG2319  80 AVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSAdGTVRLWDLATG---KLLR 156

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361151 496 QLDclNRDNYIRSCKLLPDGRSLIVGGEASTLSIWDLAapTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVWD 575
Cdd:COG2319 157 TLT--GHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLA--TGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWD 232

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361151 576 LQNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLREGRQLQQ-HDFSSQIFSLGHCPNQDWLAVGMESSNV 654
Cdd:COG2319 233 LATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTlTGHSGGVNSVAFSPDGKLLASGSDDGTV 312

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361151 655 EILHVRKPEK-YQLHLHESCVLSLKFASCGRWFVSTGKDNLLNAWRTPYGASIFQSKE-SSSVLSCDISRNNKYIVTGSG 732
Cdd:COG2319 313 RLWDLATGKLlRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGhTGAVTSVAFSPDGRTLASGSA 392


                ....*....
gi 21361151 733 DKKATVYEV 741
Cdd:COG2319 393 DGTVRLWDL 401
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 126-366 3.46e-08

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 57.26  E-value: 3.46e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361151   126 LQPLSHHAPPVPLTPRPAGLVGGSATGLLALSGALAAQAQLAAAVKEDR----AGVEAEGSRVERAPSRSASPSPPESLV 201
Cdd:PHA03247 2617 LPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRrarrLGRAAQASSPPQRPRRRAARPTVGSLT 2696

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361151   202 EEERPSGPGGGGKQRADEKEPSGPYESDEDKSDYNLVVDEDQPSEPPSPAT--TPCGKVPICIPARRDLVDSPASLASSL 279
Cdd:PHA03247 2697 SLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGpaTPGGPARPARPPTTAGPPAPAPPAAPA 2776

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361151   280 GSPLPRAKELILNDLPASTPASKSCDSSPPQDASTPGPSSASHLCQLAAKPAPSTDSVALRSPLTLSSPFTTSFSLGSHS 359
Cdd:PHA03247 2777 AGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSV 2856


                  ....*..
gi 21361151   360 TLNGDLS 366
Cdd:PHA03247 2857 APGGDVR 2863
 
Name Accession Description Interval E-value
TLE_N pfam03920
Groucho/TLE N-terminal Q-rich domain; The N-terminal domain of the Grouch/TLE co-repressor ...
 17-132 7.05e-87

Groucho/TLE N-terminal Q-rich domain; The N-terminal domain of the Grouch/TLE co-repressor proteins are involved in oligomerization.


Pssm-ID: 461094  Cd Length: 117  Bit Score: 268.91  E-value: 7.05e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361151    17 FKFSILEICDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSYGLNIEMHKQAEIVKRLSGICAQIIPFLT 96
Cdd:pfam03920   1 FKFTVPETCDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSYGLNIEMHKQTEIAKRLNAICAQVIPFLS 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 21361151    97 QEHQQQVLQAVERAKQVTVGELNSLIGQQLQPLSHH 132
Cdd:pfam03920  81 QEHQQQVAQAVERAKQVTMAELNAIIGQQQQLQAQH 116
WD40 COG2319
WD40 repeat [General function prediction only];
417-741 2.61e-41

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 155.84  E-value: 2.61e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361151 417 PAYSFHVSADGQMQPVPFPSDALVGAGIPRHARQLHTLAHGEVVCAVTISGSTQHVYTGGK-GCVKVWDVGQPgakTPVA 495
Cdd:COG2319  80 AVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSAdGTVRLWDLATG---KLLR 156

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361151 496 QLDclNRDNYIRSCKLLPDGRSLIVGGEASTLSIWDLAapTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVWD 575
Cdd:COG2319 157 TLT--GHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLA--TGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWD 232

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361151 576 LQNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLREGRQLQQ-HDFSSQIFSLGHCPNQDWLAVGMESSNV 654
Cdd:COG2319 233 LATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTlTGHSGGVNSVAFSPDGKLLASGSDDGTV 312

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361151 655 EILHVRKPEK-YQLHLHESCVLSLKFASCGRWFVSTGKDNLLNAWRTPYGASIFQSKE-SSSVLSCDISRNNKYIVTGSG 732
Cdd:COG2319 313 RLWDLATGKLlRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGhTGAVTSVAFSPDGRTLASGSA 392


                ....*....
gi 21361151 733 DKKATVYEV 741
Cdd:COG2319 393 DGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 456-740 2.26e-36

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 138.62  E-value: 2.26e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361151 456 HGEVVCAVTISGSTQHVYTGGK-GCVKVWDVgqpgaKTPVAQLDCLNRDNYIRSCKLLPDGRSLIVGGEASTLSIWDLaa 534
Cdd:cd00200   8 HTGGVTCVAFSPDGKLLATGSGdGTIKVWDL-----ETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL-- 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361151 535 PTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVWDLQNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVR 614
Cdd:cd00200  81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361151 615 CWDLREGR---QLQQHDfsSQIFSLGHCPNQDWLAVGMESSNVEILHVRKPE-KYQLHLHESCVLSLKFASCGRWFVSTG 690
Cdd:cd00200 161 LWDLRTGKcvaTLTGHT--GEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKcLGTLRGHENGVNSVAFSPDGYLLASGS 238

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 21361151 691 KDNLLNAWRTPYGASIFQ-SKESSSVLSCDISRNNKYIVTGSGDKKATVYE 740
Cdd:cd00200 239 EDGTIRVWDLRTGECVQTlSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
PHA03247 PHA03247
large tegument protein UL36; Provisional
 126-366 3.46e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 57.26  E-value: 3.46e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361151   126 LQPLSHHAPPVPLTPRPAGLVGGSATGLLALSGALAAQAQLAAAVKEDR----AGVEAEGSRVERAPSRSASPSPPESLV 201
Cdd:PHA03247 2617 LPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRrarrLGRAAQASSPPQRPRRRAARPTVGSLT 2696

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361151   202 EEERPSGPGGGGKQRADEKEPSGPYESDEDKSDYNLVVDEDQPSEPPSPAT--TPCGKVPICIPARRDLVDSPASLASSL 279
Cdd:PHA03247 2697 SLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGpaTPGGPARPARPPTTAGPPAPAPPAAPA 2776

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361151   280 GSPLPRAKELILNDLPASTPASKSCDSSPPQDASTPGPSSASHLCQLAAKPAPSTDSVALRSPLTLSSPFTTSFSLGSHS 359
Cdd:PHA03247 2777 AGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSV 2856


                  ....*..
gi 21361151   360 TLNGDLS 366
Cdd:PHA03247 2857 APGGDVR 2863
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 582-617 5.40e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.54  E-value: 5.40e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 21361151    582 VRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWD 617
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
582-617 7.82e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.10  E-value: 7.82e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 21361151   582 VRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWD 617
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
TLE_N pfam03920
Groucho/TLE N-terminal Q-rich domain; The N-terminal domain of the Grouch/TLE co-repressor ...
 17-132 7.05e-87

Groucho/TLE N-terminal Q-rich domain; The N-terminal domain of the Grouch/TLE co-repressor proteins are involved in oligomerization.


Pssm-ID: 461094  Cd Length: 117  Bit Score: 268.91  E-value: 7.05e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361151    17 FKFSILEICDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSYGLNIEMHKQAEIVKRLSGICAQIIPFLT 96
Cdd:pfam03920   1 FKFTVPETCDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSYGLNIEMHKQTEIAKRLNAICAQVIPFLS 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 21361151    97 QEHQQQVLQAVERAKQVTVGELNSLIGQQLQPLSHH 132
Cdd:pfam03920  81 QEHQQQVAQAVERAKQVTMAELNAIIGQQQQLQAQH 116
WD40 COG2319
WD40 repeat [General function prediction only];
417-741 2.61e-41

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 155.84  E-value: 2.61e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361151 417 PAYSFHVSADGQMQPVPFPSDALVGAGIPRHARQLHTLAHGEVVCAVTISGSTQHVYTGGK-GCVKVWDVGQPgakTPVA 495
Cdd:COG2319  80 AVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSAdGTVRLWDLATG---KLLR 156

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361151 496 QLDclNRDNYIRSCKLLPDGRSLIVGGEASTLSIWDLAapTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVWD 575
Cdd:COG2319 157 TLT--GHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLA--TGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWD 232

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361151 576 LQNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLREGRQLQQ-HDFSSQIFSLGHCPNQDWLAVGMESSNV 654
Cdd:COG2319 233 LATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTlTGHSGGVNSVAFSPDGKLLASGSDDGTV 312

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361151 655 EILHVRKPEK-YQLHLHESCVLSLKFASCGRWFVSTGKDNLLNAWRTPYGASIFQSKE-SSSVLSCDISRNNKYIVTGSG 732
Cdd:COG2319 313 RLWDLATGKLlRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGhTGAVTSVAFSPDGRTLASGSA 392


                ....*....
gi 21361151 733 DKKATVYEV 741
Cdd:COG2319 393 DGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 456-740 2.26e-36

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 138.62  E-value: 2.26e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361151 456 HGEVVCAVTISGSTQHVYTGGK-GCVKVWDVgqpgaKTPVAQLDCLNRDNYIRSCKLLPDGRSLIVGGEASTLSIWDLaa 534
Cdd:cd00200   8 HTGGVTCVAFSPDGKLLATGSGdGTIKVWDL-----ETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL-- 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361151 535 PTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVWDLQNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVR 614
Cdd:cd00200  81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361151 615 CWDLREGR---QLQQHDfsSQIFSLGHCPNQDWLAVGMESSNVEILHVRKPE-KYQLHLHESCVLSLKFASCGRWFVSTG 690
Cdd:cd00200 161 LWDLRTGKcvaTLTGHT--GEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKcLGTLRGHENGVNSVAFSPDGYLLASGS 238

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 21361151 691 KDNLLNAWRTPYGASIFQ-SKESSSVLSCDISRNNKYIVTGSGDKKATVYE 740
Cdd:cd00200 239 EDGTIRVWDLRTGECVQTlSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
449-701 5.72e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 140.43  E-value: 5.72e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361151 449 RQLHTL-AHGEVVCAVTISGSTQHVYTGGK-GCVKVWDVGQPgakTPVAQLDclNRDNYIRSCKLLPDGRSLIVGGEAST 526
Cdd:COG2319 153 KLLRTLtGHSGAVTSVAFSPDGKLLASGSDdGTVRLWDLATG---KLLRTLT--GHTGAVRSVAFSPDGKLLASGSADGT 227

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361151 527 LSIWDLAapTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVWDLQNQTMVRQFQGHTDGASCIDISDYGTRLWT 606
Cdd:COG2319 228 VRLWDLA--TGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLAS 305

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361151 607 GGLDNTVRCWDLREGRQLQQHD-FSSQIFSLGHCPNQDWLAVGMESSNVEILHVR-KPEKYQLHLHESCVLSLKFASCGR 684
Cdd:COG2319 306 GSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLAtGELLRTLTGHTGAVTSVAFSPDGR 385

                       250
                ....*....|....*..
gi 21361151 685 WFVSTGKDNLLNAWRTP 701
Cdd:COG2319 386 TLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 449-699 6.08e-34

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 131.69  E-value: 6.08e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361151 449 RQLHTL-AHGEVVCAVTISGSTQHVYTGGK-GCVKVWDVGQPgaktpvaqlDCLNR----DNYIRSCKLLPDGRSLIVGG 522
Cdd:cd00200  42 ELLRTLkGHTGPVRDVAASADGTYLASGSSdKTIRLWDLETG---------ECVRTltghTSYVSSVAFSPDGRILSSSS 112

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361151 523 EASTLSIWDLaaPTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVWDLQNQTMVRQFQGHTDGASCIDISDYGT 602
Cdd:cd00200 113 RDKTIKVWDV--ETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGE 190

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361151 603 RLWTGGLDNTVRCWDLREGRQLQQHD-FSSQIFSLGHCPNQDWLAVGMESSNVEILHVRKPE-KYQLHLHESCVLSLKFA 680
Cdd:cd00200 191 KLLSSSSDGTIKLWDLSTGKCLGTLRgHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGEcVQTLSGHTNSVTSLAWS 270

                       250
                ....*....|....*....
gi 21361151 681 SCGRWFVSTGKDNLLNAWR 699
Cdd:cd00200 271 PDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
483-741 3.84e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 114.62  E-value: 3.84e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361151 483 WDVGQPGAKTPVAQLDCLNRDNYIRSCKLLPDGRSLIVGGEASTLSIWDLAAPTPRIKAELTSSAPacYALAVSPDAKVC 562
Cdd:COG2319  16 LALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAV--LSVAFSPDGRLL 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361151 563 FSCCSDGNIVVWDLQNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLREGRQLQQ-HDFSSQIFSLGHCPN 641
Cdd:COG2319  94 ASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTlTGHSGAVTSVAFSPD 173

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361151 642 QDWLAVGMESSNVEILHVRKPEKYQ-LHLHESCVLSLKFASCGRWFVSTGKDNLLNAWRTPYGASIFQSK-ESSSVLSCD 719
Cdd:COG2319 174 GKLLASGSDDGTVRLWDLATGKLLRtLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTgHSGSVRSVA 253

                       250       260
                ....*....|....*....|..
gi 21361151 720 ISRNNKYIVTGSGDKKATVYEV 741
Cdd:COG2319 254 FSPDGRLLASGSADGTVRLWDL 275
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 550-741 1.34e-24

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 104.34  E-value: 1.34e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361151 550 CYALAVSPDAKVCFSCCSDGNIVVWDLQNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLREGRQLQQ-HD 628
Cdd:cd00200  12 VTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTlTG 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361151 629 FSSQIFSLGHCPNQDWLAVGMESSNVEILHVRKPE-KYQLHLHESCVLSLKFASCGRwFVSTGK-DNLLNAWRTPYGASI 706
Cdd:cd00200  92 HTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKcLTTLRGHTDWVNSVAFSPDGT-FVASSSqDGTIKLWDLRTGKCV 170

                       170       180       190
                ....*....|....*....|....*....|....*..
gi 21361151 707 --FQSkESSSVLSCDISRNNKYIVTGSGDKKATVYEV 741
Cdd:cd00200 171 atLTG-HTGEVNSVAFSPDGEKLLSSSSDGTIKLWDL 206
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 581-741 1.68e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 86.62  E-value: 1.68e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361151 581 MVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLREG---RQLQQHdfSSQIFSLGHCPNQDWLAVGMESSNVEIL 657
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGellRTLKGH--TGPVRDVAASADGTYLASGSSDKTIRLW 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361151 658 HVRKPEK-YQLHLHESCVLSLKFASCGRWFVSTGKDNLLNAWRTPYGASI--FQSKEsSSVLSCDISRNNKYIVTGSGDK 734
Cdd:cd00200  79 DLETGECvRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLttLRGHT-DWVNSVAFSPDGTFVASSSQDG 157


                ....*..
gi 21361151 735 KATVYEV 741
Cdd:cd00200 158 TIKLWDL 164
WD40 COG2319
WD40 repeat [General function prediction only];
511-741 6.63e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 86.50  E-value: 6.63e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361151 511 LLPDGRSLIVGGEASTLSIWDLAAPTPRIKAELTSSAPAcyALAVSPDAKVCFSCCSDGNIVVWDLQNQTMVRQFQGHTD 590
Cdd:COG2319   2 LSADGAALAAASADLALALLAAALGALLLLLLGLAAAVA--SLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTA 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361151 591 GASCIDISDYGTRLWTGGLDNTVRCWDLREGRQLQQ-HDFSSQIFSLGHCPNQDWLAVGMESSNVEILHVRKPEK-YQLH 668
Cdd:COG2319  80 AVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTlTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLlRTLT 159

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 21361151 669 LHESCVLSLKFASCGRWFVSTGKDNLLNAWRTPYGASIFQ-SKESSSVLSCDISRNNKYIVTGSGDKKATVYEV 741
Cdd:COG2319 160 GHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTlTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDL 233
WD40 COG2319
WD40 repeat [General function prediction only];
415-578 3.68e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 71.87  E-value: 3.68e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361151 415 GKPAYSFHVSADGQMqpvpfpsdaLVGAGIPRHAR--------QLHTLA-HGEVVCAVTISGSTQHVYTGGKGC-VKVWD 484
Cdd:COG2319 246 SGSVRSVAFSPDGRL---------LASGSADGTVRlwdlatgeLLRTLTgHSGGVNSVAFSPDGKLLASGSDDGtVRLWD 316

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361151 485 VGQPgakTPVAQLDclNRDNYIRSCKLLPDGRSLIVGGEASTLSIWDLAapTPRIKAELTSSAPACYALAVSPDAKVCFS 564
Cdd:COG2319 317 LATG---KLLRTLT--GHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLA--TGELLRTLTGHTGAVTSVAFSPDGRTLAS 389

                       170
                ....*....|....
gi 21361151 565 CCSDGNIVVWDLQN 578
Cdd:COG2319 390 GSADGTVRLWDLAT 403
PHA03247 PHA03247
large tegument protein UL36; Provisional
 126-366 3.46e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 57.26  E-value: 3.46e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361151   126 LQPLSHHAPPVPLTPRPAGLVGGSATGLLALSGALAAQAQLAAAVKEDR----AGVEAEGSRVERAPSRSASPSPPESLV 201
Cdd:PHA03247 2617 LPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRrarrLGRAAQASSPPQRPRRRAARPTVGSLT 2696

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361151   202 EEERPSGPGGGGKQRADEKEPSGPYESDEDKSDYNLVVDEDQPSEPPSPAT--TPCGKVPICIPARRDLVDSPASLASSL 279
Cdd:PHA03247 2697 SLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGpaTPGGPARPARPPTTAGPPAPAPPAAPA 2776

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361151   280 GSPLPRAKELILNDLPASTPASKSCDSSPPQDASTPGPSSASHLCQLAAKPAPSTDSVALRSPLTLSSPFTTSFSLGSHS 359
Cdd:PHA03247 2777 AGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSV 2856


                  ....*..
gi 21361151   360 TLNGDLS 366
Cdd:PHA03247 2857 APGGDVR 2863
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 582-617 5.40e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.54  E-value: 5.40e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 21361151    582 VRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWD 617
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
582-617 7.82e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.10  E-value: 7.82e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 21361151   582 VRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWD 617
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
384-618 3.55e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 42.76  E-value: 3.55e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361151 384 VVYGRSPVMAFESHPHLRGSSVSSSLPSIPGGKPAYSFHVSADGQMQPVPFPSDALVGAGIPRHARQLHTLAHGEVVcav 463
Cdd:COG3391   1 ALVASSLLVAVLLAVLALAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGA--- 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361151 464 tiSGSTQHVYTGGKGCVKVWDvgqPGAKTPVAQLDCLNRDNYIRsckLLPDGRSLIVGGEAS-TLSIWDLAapTPRIKAE 542
Cdd:COG3391  78 --DGRRLYVANSGSGRVSVID---LATGKVVATIPVGGGPRGLA---VDPDGGRLYVADSGNgRVSVIDTA--TGKVVAT 147

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21361151 543 L-TSSAPacYALAVSPDAKVCFSCCSDGN-----IVVWDLQNQTMVRQFQGHtDGASCIDISDYGTRLW--------TGG 608
Cdd:COG3391 148 IpVGAGP--HGIAVDPDGKRLYVANSGSNtvsviVSVIDTATGKVVATIPVG-GGPVGVAVSPDGRRLYvanrgsntSNG 224

                       250
                ....*....|
gi 21361151 609 LDNTVRCWDL 618
Cdd:COG3391 225 GSNTVSVIDL 234
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 536-575 1.30e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 1.30e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 21361151    536 TPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVWD 575
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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