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Conserved domains on  [gi|33239440|ref|NP_003402|]
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zinc finger Y-chromosomal protein isoform 1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Zfx_Zfy_act pfam04704
Zfx / Zfy transcription activation region; Zfx and Zfy are transcription factors implicated in ...
 71-406 1.04e-177

Zfx / Zfy transcription activation region; Zfx and Zfy are transcription factors implicated in mammalian sex determination. This region is found N terminal to multiple copies of a C2H2 Zinc finger (pfam00096). This region has been shown to activate transcription when fused to a GAL4 DNA binding domain.


:

Pssm-ID: 461400  Cd Length: 328  Bit Score: 512.87  E-value: 1.04e-177
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33239440    71 DVVIEeDVQCSDILEEADVSENVIIPEQVLDSDVTEEVSLPHCTVPDDVLASDITSTSMSMPEHVLTSESMHVCDIGHVE 150
Cdd:pfam04704   1 DVVIE-DVQCPDILEETDVSEGVIIPEQVLDSEVAIEVSLDHCTVPDDVLTSDLISESMTMPEQVFVAELVSVPEVGHLE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33239440   151 HMVHDSvvEAEIITDPLTSDIVSEEVLVADCAPEAVIDASGISVDQQDNDKASCEDYLMISLDDAGKIEHDGSTGVTIDA 230
Cdd:pfam04704  80 HVIHDS--EREIVTDALTADMVSEEVLVADCASEAVIDASGVPLETQDDDKSNCEDYLMISLDDGEKLDHIGSTPLTMSA 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33239440   231 ESEMDPCKVDSTCPEVIKVYIFKADPGEDDLGGTVDIVESEPENDHGVELLDQNSSIRVPREKMVYMTVNDSQQEDEDLN 310
Cdd:pfam04704 158 EVEQDSSKLDGFCPEVIKVYIFKADPGEDDLGGTEDIVESEFENGHGVLLLEQGSSGRLPREKMVYMAVKDSQQEDEDLN 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33239440   311 VAEIADEVYMEVIVGEEDaavaaaAAAVHEQQIDEDEM-KTFVPIAWAAAYGNNSDGIENRNGTASALLHIDESAGLGRL 389
Cdd:pfam04704 238 VAEIADEVYMEVIVGEED------AAVAHEQQLDDSEVnKTFMPIAWAAAYGNNTDGIENKNGTASALLHIDESASLDRL 311

                         330
                  ....*....|....*..
gi 33239440   390 AKQKPKKKRRPDSRQYQ 406
Cdd:pfam04704 312 LKQKPKKKRRGESRQYQ 328
zf-H2C2_2 pfam13465
Zinc-finger double domain;
558-582 4.36e-05

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.82  E-value: 4.36e-05
                          10        20
                  ....*....|....*....|....*
gi 33239440   558 ELRKHMRIHTGEKPYQCQYCEYRSA 582
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
539-676 1.07e-04

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.46  E-value: 1.07e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33239440 539 SKNFPHICVECGKGFRHPSELRKHMRIHTGEKPYQCQYCEYRSADSSNLKTHI-KTKHSKEMPFKCDICLLTFSDTKEVQ 617
Cdd:COG5048  29 NAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRhLRTHHNNPSDLNSKSLPLSNSKASSS 108

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 33239440 618 QHTLVHQESKTHQCLHCDHKSSNSSDLKRHVISVHTKDYPHKCEMC-EKGFHRPSELKKH 676
Cdd:COG5048 109 SLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLH 168
zf-H2C2_2 pfam13465
Zinc-finger double domain;
729-753 7.58e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 7.58e-04
                          10        20
                  ....*....|....*....|....*
gi 33239440   729 ELKKHMKTHSGRKVYQCEYCEYSTT 753
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
COG5048 super family cl34881
FOG: Zn-finger [General function prediction only];
417-592 1.28e-03

FOG: Zn-finger [General function prediction only];


The actual alignment was detected with superfamily member COG5048:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.99  E-value: 1.28e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33239440 417 PLTVYPCMICGKKFKSRGFLKRHMKNHPEHLAKKKYHCTDCDYTTnKKISLHNHLESHKLTS-KAEKAIEC-DECGKHFS 494
Cdd:COG5048 286 FSLPIKSKQCNISFSRSSPLTRHLRSVNHSGESLKPFSCPYSLCG-KLFSRNDALKRHILLHtSISPAKEKlLNSSSKFS 364

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33239440 495 HAGALFTHKMVHKEKGANKMHKckfceYETAEQGLL----NRHLLAVH---SKNFPHICVE---CGKGFRHPSELRKHMR 564
Cdd:COG5048 365 PLLNNEPPQSLQQYKDLKNDKK-----SETLSNSCIrnfkRDSNLSLHiitHLSFRPYNCKnppCSKSFNRHYNLIPHKK 439

                       170       180
                ....*....|....*....|....*...
gi 33239440 565 IHTGEKPYQCQyCEYRSADSSNLKTHIK 592
Cdd:COG5048 440 IHTNHAPLLCS-ILKSFRRDLDLSNHGK 466
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 715-737 5.02e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


:

Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 5.02e-03
                          10        20
                  ....*....|....*....|...
gi 33239440   715 FRCKRCRKGFRQQNELKKHMKTH 737
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Name Accession Description Interval E-value
Zfx_Zfy_act pfam04704
Zfx / Zfy transcription activation region; Zfx and Zfy are transcription factors implicated in ...
 71-406 1.04e-177

Zfx / Zfy transcription activation region; Zfx and Zfy are transcription factors implicated in mammalian sex determination. This region is found N terminal to multiple copies of a C2H2 Zinc finger (pfam00096). This region has been shown to activate transcription when fused to a GAL4 DNA binding domain.


Pssm-ID: 461400  Cd Length: 328  Bit Score: 512.87  E-value: 1.04e-177
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33239440    71 DVVIEeDVQCSDILEEADVSENVIIPEQVLDSDVTEEVSLPHCTVPDDVLASDITSTSMSMPEHVLTSESMHVCDIGHVE 150
Cdd:pfam04704   1 DVVIE-DVQCPDILEETDVSEGVIIPEQVLDSEVAIEVSLDHCTVPDDVLTSDLISESMTMPEQVFVAELVSVPEVGHLE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33239440   151 HMVHDSvvEAEIITDPLTSDIVSEEVLVADCAPEAVIDASGISVDQQDNDKASCEDYLMISLDDAGKIEHDGSTGVTIDA 230
Cdd:pfam04704  80 HVIHDS--EREIVTDALTADMVSEEVLVADCASEAVIDASGVPLETQDDDKSNCEDYLMISLDDGEKLDHIGSTPLTMSA 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33239440   231 ESEMDPCKVDSTCPEVIKVYIFKADPGEDDLGGTVDIVESEPENDHGVELLDQNSSIRVPREKMVYMTVNDSQQEDEDLN 310
Cdd:pfam04704 158 EVEQDSSKLDGFCPEVIKVYIFKADPGEDDLGGTEDIVESEFENGHGVLLLEQGSSGRLPREKMVYMAVKDSQQEDEDLN 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33239440   311 VAEIADEVYMEVIVGEEDaavaaaAAAVHEQQIDEDEM-KTFVPIAWAAAYGNNSDGIENRNGTASALLHIDESAGLGRL 389
Cdd:pfam04704 238 VAEIADEVYMEVIVGEED------AAVAHEQQLDDSEVnKTFMPIAWAAAYGNNTDGIENKNGTASALLHIDESASLDRL 311

                         330
                  ....*....|....*..
gi 33239440   390 AKQKPKKKRRPDSRQYQ 406
Cdd:pfam04704 312 LKQKPKKKRRGESRQYQ 328
zf-H2C2_2 pfam13465
Zinc-finger double domain;
558-582 4.36e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.82  E-value: 4.36e-05
                          10        20
                  ....*....|....*....|....*
gi 33239440   558 ELRKHMRIHTGEKPYQCQYCEYRSA 582
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
539-676 1.07e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.46  E-value: 1.07e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33239440 539 SKNFPHICVECGKGFRHPSELRKHMRIHTGEKPYQCQYCEYRSADSSNLKTHI-KTKHSKEMPFKCDICLLTFSDTKEVQ 617
Cdd:COG5048  29 NAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRhLRTHHNNPSDLNSKSLPLSNSKASSS 108

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 33239440 618 QHTLVHQESKTHQCLHCDHKSSNSSDLKRHVISVHTKDYPHKCEMC-EKGFHRPSELKKH 676
Cdd:COG5048 109 SLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLH 168
zf-H2C2_2 pfam13465
Zinc-finger double domain;
729-753 7.58e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 7.58e-04
                          10        20
                  ....*....|....*....|....*
gi 33239440   729 ELKKHMKTHSGRKVYQCEYCEYSTT 753
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
417-592 1.28e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.99  E-value: 1.28e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33239440 417 PLTVYPCMICGKKFKSRGFLKRHMKNHPEHLAKKKYHCTDCDYTTnKKISLHNHLESHKLTS-KAEKAIEC-DECGKHFS 494
Cdd:COG5048 286 FSLPIKSKQCNISFSRSSPLTRHLRSVNHSGESLKPFSCPYSLCG-KLFSRNDALKRHILLHtSISPAKEKlLNSSSKFS 364

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33239440 495 HAGALFTHKMVHKEKGANKMHKckfceYETAEQGLL----NRHLLAVH---SKNFPHICVE---CGKGFRHPSELRKHMR 564
Cdd:COG5048 365 PLLNNEPPQSLQQYKDLKNDKK-----SETLSNSCIrnfkRDSNLSLHiitHLSFRPYNCKnppCSKSFNRHYNLIPHKK 439

                       170       180
                ....*....|....*....|....*...
gi 33239440 565 IHTGEKPYQCQyCEYRSADSSNLKTHIK 592
Cdd:COG5048 440 IHTNHAPLLCS-ILKSFRRDLDLSNHGK 466
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 544-566 1.52e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.51  E-value: 1.52e-03
                          10        20
                  ....*....|....*....|...
gi 33239440   544 HICVECGKGFRHPSELRKHMRIH 566
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
ROS_MUCR pfam05443
ROS/MUCR transcriptional regulator protein; This family consists of several ROS/MUCR ...
 423-445 4.22e-03

ROS/MUCR transcriptional regulator protein; This family consists of several ROS/MUCR transcriptional regulator proteins. The ros chromosomal gene is present in octopine and nopaline strains of Agrobacterium tumefaciens as well as in Rhizobium meliloti. This gene encodes a 15.5-kDa protein that specifically represses the virC and virD operons in the virulence region of the Ti plasmid and is necessary for succinoglycan production. Sinorhizobium meliloti can produce two types of acidic exopolysaccharides, succinoglycan and galactoglucan, that are interchangeable for infection of alfalfa nodules. MucR from Sinorhizobium meliloti acts as a transcriptional repressor that blocks the expression of the exp genes responsible for galactoglucan production therefore allowing the exclusive production of succinoglycan.


Pssm-ID: 428475  Cd Length: 122  Bit Score: 37.83  E-value: 4.22e-03
                          10        20
                  ....*....|....*....|....*.
gi 33239440   423 CMICGKKFKSrgfLKRHMKNH---PE 445
Cdd:pfam05443  67 CLEDGKPFKT---LKRHLTAHgltPE 89
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 715-737 5.02e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 5.02e-03
                          10        20
                  ....*....|....*....|...
gi 33239440   715 FRCKRCRKGFRQQNELKKHMKTH 737
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Name Accession Description Interval E-value
Zfx_Zfy_act pfam04704
Zfx / Zfy transcription activation region; Zfx and Zfy are transcription factors implicated in ...
 71-406 1.04e-177

Zfx / Zfy transcription activation region; Zfx and Zfy are transcription factors implicated in mammalian sex determination. This region is found N terminal to multiple copies of a C2H2 Zinc finger (pfam00096). This region has been shown to activate transcription when fused to a GAL4 DNA binding domain.


Pssm-ID: 461400  Cd Length: 328  Bit Score: 512.87  E-value: 1.04e-177
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33239440    71 DVVIEeDVQCSDILEEADVSENVIIPEQVLDSDVTEEVSLPHCTVPDDVLASDITSTSMSMPEHVLTSESMHVCDIGHVE 150
Cdd:pfam04704   1 DVVIE-DVQCPDILEETDVSEGVIIPEQVLDSEVAIEVSLDHCTVPDDVLTSDLISESMTMPEQVFVAELVSVPEVGHLE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33239440   151 HMVHDSvvEAEIITDPLTSDIVSEEVLVADCAPEAVIDASGISVDQQDNDKASCEDYLMISLDDAGKIEHDGSTGVTIDA 230
Cdd:pfam04704  80 HVIHDS--EREIVTDALTADMVSEEVLVADCASEAVIDASGVPLETQDDDKSNCEDYLMISLDDGEKLDHIGSTPLTMSA 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33239440   231 ESEMDPCKVDSTCPEVIKVYIFKADPGEDDLGGTVDIVESEPENDHGVELLDQNSSIRVPREKMVYMTVNDSQQEDEDLN 310
Cdd:pfam04704 158 EVEQDSSKLDGFCPEVIKVYIFKADPGEDDLGGTEDIVESEFENGHGVLLLEQGSSGRLPREKMVYMAVKDSQQEDEDLN 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33239440   311 VAEIADEVYMEVIVGEEDaavaaaAAAVHEQQIDEDEM-KTFVPIAWAAAYGNNSDGIENRNGTASALLHIDESAGLGRL 389
Cdd:pfam04704 238 VAEIADEVYMEVIVGEED------AAVAHEQQLDDSEVnKTFMPIAWAAAYGNNTDGIENKNGTASALLHIDESASLDRL 311

                         330
                  ....*....|....*..
gi 33239440   390 AKQKPKKKRRPDSRQYQ 406
Cdd:pfam04704 312 LKQKPKKKRRGESRQYQ 328
zf-H2C2_2 pfam13465
Zinc-finger double domain;
558-582 4.36e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.82  E-value: 4.36e-05
                          10        20
                  ....*....|....*....|....*
gi 33239440   558 ELRKHMRIHTGEKPYQCQYCEYRSA 582
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
539-676 1.07e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.46  E-value: 1.07e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33239440 539 SKNFPHICVECGKGFRHPSELRKHMRIHTGEKPYQCQYCEYRSADSSNLKTHI-KTKHSKEMPFKCDICLLTFSDTKEVQ 617
Cdd:COG5048  29 NAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRhLRTHHNNPSDLNSKSLPLSNSKASSS 108

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 33239440 618 QHTLVHQESKTHQCLHCDHKSSNSSDLKRHVISVHTKDYPHKCEMC-EKGFHRPSELKKH 676
Cdd:COG5048 109 SLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLH 168
zf-H2C2_2 pfam13465
Zinc-finger double domain;
729-753 7.58e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 7.58e-04
                          10        20
                  ....*....|....*....|....*
gi 33239440   729 ELKKHMKTHSGRKVYQCEYCEYSTT 753
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
417-592 1.28e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.99  E-value: 1.28e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33239440 417 PLTVYPCMICGKKFKSRGFLKRHMKNHPEHLAKKKYHCTDCDYTTnKKISLHNHLESHKLTS-KAEKAIEC-DECGKHFS 494
Cdd:COG5048 286 FSLPIKSKQCNISFSRSSPLTRHLRSVNHSGESLKPFSCPYSLCG-KLFSRNDALKRHILLHtSISPAKEKlLNSSSKFS 364

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33239440 495 HAGALFTHKMVHKEKGANKMHKckfceYETAEQGLL----NRHLLAVH---SKNFPHICVE---CGKGFRHPSELRKHMR 564
Cdd:COG5048 365 PLLNNEPPQSLQQYKDLKNDKK-----SETLSNSCIrnfkRDSNLSLHiitHLSFRPYNCKnppCSKSFNRHYNLIPHKK 439

                       170       180
                ....*....|....*....|....*...
gi 33239440 565 IHTGEKPYQCQyCEYRSADSSNLKTHIK 592
Cdd:COG5048 440 IHTNHAPLLCS-ILKSFRRDLDLSNHGK 466
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 544-566 1.52e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.51  E-value: 1.52e-03
                          10        20
                  ....*....|....*....|...
gi 33239440   544 HICVECGKGFRHPSELRKHMRIH 566
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
ROS_MUCR pfam05443
ROS/MUCR transcriptional regulator protein; This family consists of several ROS/MUCR ...
 423-445 4.22e-03

ROS/MUCR transcriptional regulator protein; This family consists of several ROS/MUCR transcriptional regulator proteins. The ros chromosomal gene is present in octopine and nopaline strains of Agrobacterium tumefaciens as well as in Rhizobium meliloti. This gene encodes a 15.5-kDa protein that specifically represses the virC and virD operons in the virulence region of the Ti plasmid and is necessary for succinoglycan production. Sinorhizobium meliloti can produce two types of acidic exopolysaccharides, succinoglycan and galactoglucan, that are interchangeable for infection of alfalfa nodules. MucR from Sinorhizobium meliloti acts as a transcriptional repressor that blocks the expression of the exp genes responsible for galactoglucan production therefore allowing the exclusive production of succinoglycan.


Pssm-ID: 428475  Cd Length: 122  Bit Score: 37.83  E-value: 4.22e-03
                          10        20
                  ....*....|....*....|....*.
gi 33239440   423 CMICGKKFKSrgfLKRHMKNH---PE 445
Cdd:pfam05443  67 CLEDGKPFKT---LKRHLTAHgltPE 89
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 715-737 5.02e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 5.02e-03
                          10        20
                  ....*....|....*....|...
gi 33239440   715 FRCKRCRKGFRQQNELKKHMKTH 737
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 421-443 7.73e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 7.73e-03
                          10        20
                  ....*....|....*....|...
gi 33239440   421 YPCMICGKKFKSRGFLKRHMKNH 443
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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