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Conserved domains on  [gi|169790765|ref|NP_003420|]
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zinc finger protein 85 isoform a [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204268)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development, and in regulating viral replication and transcription

CATH:  3.30.160.60
Gene Ontology:  GO:0003700|GO:0046872
PubMed:  22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
4-64 8.67e-33

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 120.00  E-value: 8.67e-33
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 169790765     4 LTFRDVAIEFSLKEWQCLDTAQRNLYRNVMLENYRNLVFLGITVSKPDLITCLEQGKEAWS 64
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
228-589 3.15e-15

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 78.20  E-value: 3.15e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790765 228 KPYKCEECGKAFNQSSNLIKHKKIHTGEKPYKC--EECGKTFNRFSTLTTHKIIHTGEKPYKC-KECGKAFNRSSTLTTH 304
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790765 305 RKIHTGEKPYKCEECGKAFKQSSNLT--THKIIHTGEKPYK-CKKCGKAFNQSAHL-------------------TTHEV 362
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLpdLLSISNLRNNPLPgNNSSSVNTPQSNSLhpplpanslskdpssnlslLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790765 363 IHTGEKPYKCEKCGKAFNHFSHLTTHKIIHTGEKPYKCKECGKAFKHSSTLTKHKIIHTGEKPYKCKECEKAFNQSSKLT 442
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790765 443 EHKKIHTGE-------KPYECEKCGKAFNQSSNLTRHKKS--HTEE--KPYKCEE--CGKGFKWPSTLTIHKIIHTGEKP 509
Cdd:COG5048  272 SSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790765 510 YKC--EECGKAFNQSS-----KLTKHKKIHTGEKPYTCE--ECGKAFNQSSNLTKHKRIHTGEKP--YKCEECDKAFKWS 578
Cdd:COG5048  352 AKEklLNSSSKFSPLLnneppQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRH 431

                        410
                 ....*....|.
gi 169790765 579 SVLTKHKIIHT 589
Cdd:COG5048  432 YNLIPHKKIHT 442
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
4-64 8.67e-33

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 120.00  E-value: 8.67e-33
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 169790765     4 LTFRDVAIEFSLKEWQCLDTAQRNLYRNVMLENYRNLVFLGITVSKPDLITCLEQGKEAWS 64
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-44 1.85e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 90.22  E-value: 1.85e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 169790765    3 PLTFRDVAIEFSLKEWQCLDTAQRNLYRNVMLENYRNLVFLG 44
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-43 7.45e-19

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 79.90  E-value: 7.45e-19
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 169790765   4 LTFRDVAIEFSLKEWQCLDTAQRNLYRNVMLENYRNLVFL 43
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
228-589 3.15e-15

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 78.20  E-value: 3.15e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790765 228 KPYKCEECGKAFNQSSNLIKHKKIHTGEKPYKC--EECGKTFNRFSTLTTHKIIHTGEKPYKC-KECGKAFNRSSTLTTH 304
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790765 305 RKIHTGEKPYKCEECGKAFKQSSNLT--THKIIHTGEKPYK-CKKCGKAFNQSAHL-------------------TTHEV 362
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLpdLLSISNLRNNPLPgNNSSSVNTPQSNSLhpplpanslskdpssnlslLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790765 363 IHTGEKPYKCEKCGKAFNHFSHLTTHKIIHTGEKPYKCKECGKAFKHSSTLTKHKIIHTGEKPYKCKECEKAFNQSSKLT 442
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790765 443 EHKKIHTGE-------KPYECEKCGKAFNQSSNLTRHKKS--HTEE--KPYKCEE--CGKGFKWPSTLTIHKIIHTGEKP 509
Cdd:COG5048  272 SSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790765 510 YKC--EECGKAFNQSS-----KLTKHKKIHTGEKPYTCE--ECGKAFNQSSNLTKHKRIHTGEKP--YKCEECDKAFKWS 578
Cdd:COG5048  352 AKEklLNSSSKFSPLLnneppQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRH 431

                        410
                 ....*....|.
gi 169790765 579 SVLTKHKIIHT 589
Cdd:COG5048  432 YNLIPHKKIHT 442
zf-H2C2_2 pfam13465
Zinc-finger double domain;
552-576 1.87e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.87e-04
                          10        20
                  ....*....|....*....|....*
gi 169790765  552 NLTKHKRIHTGEKPYKCEECDKAFK 576
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
4-64 8.67e-33

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 120.00  E-value: 8.67e-33
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 169790765     4 LTFRDVAIEFSLKEWQCLDTAQRNLYRNVMLENYRNLVFLGITVSKPDLITCLEQGKEAWS 64
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-44 1.85e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 90.22  E-value: 1.85e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 169790765    3 PLTFRDVAIEFSLKEWQCLDTAQRNLYRNVMLENYRNLVFLG 44
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-43 7.45e-19

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 79.90  E-value: 7.45e-19
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 169790765   4 LTFRDVAIEFSLKEWQCLDTAQRNLYRNVMLENYRNLVFL 43
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
228-589 3.15e-15

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 78.20  E-value: 3.15e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790765 228 KPYKCEECGKAFNQSSNLIKHKKIHTGEKPYKC--EECGKTFNRFSTLTTHKIIHTGEKPYKC-KECGKAFNRSSTLTTH 304
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790765 305 RKIHTGEKPYKCEECGKAFKQSSNLT--THKIIHTGEKPYK-CKKCGKAFNQSAHL-------------------TTHEV 362
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLpdLLSISNLRNNPLPgNNSSSVNTPQSNSLhpplpanslskdpssnlslLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790765 363 IHTGEKPYKCEKCGKAFNHFSHLTTHKIIHTGEKPYKCKECGKAFKHSSTLTKHKIIHTGEKPYKCKECEKAFNQSSKLT 442
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790765 443 EHKKIHTGE-------KPYECEKCGKAFNQSSNLTRHKKS--HTEE--KPYKCEE--CGKGFKWPSTLTIHKIIHTGEKP 509
Cdd:COG5048  272 SSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790765 510 YKC--EECGKAFNQSS-----KLTKHKKIHTGEKPYTCE--ECGKAFNQSSNLTKHKRIHTGEKP--YKCEECDKAFKWS 578
Cdd:COG5048  352 AKEklLNSSSKFSPLLnneppQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRH 431

                        410
                 ....*....|.
gi 169790765 579 SVLTKHKIIHT 589
Cdd:COG5048  432 YNLIPHKKIHT 442
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
240-594 5.09e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 71.27  E-value: 5.09e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790765 240 NQSSNLIKHKKIHTGE----KPYKCEECGKTFNRFSTLTTHKIIHTGEKPYKC--KECGKAFNRSSTLTTHRKIHTGEKP 313
Cdd:COG5048   12 NNSVLSSTPKSTLKSLsnapRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPS 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790765 314 YkcEECGKAFKQSSNLTTHKIIHTGEKPYKCKKC-GKAFNQSAHLTTHEVIHTGEKPYKCEKCGKAFNHFSHLTTHKIIH 392
Cdd:COG5048   92 D--LNSKSLPLSNSKASSSSLSSSSSNSNDNNLLsSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHP 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790765 393 TGEKPYKCKEcgkAFKHSSTLTKHKIIHTGEKPYKCKECEKaFNQSSKLTEHKKIHTGEKPYECEKCGKAFNQSSNLTRH 472
Cdd:COG5048  170 PLPANSLSKD---PSSNLSLLISSNVSTSIPSSSENSPLSS-SYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSP 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790765 473 KKSHTEEKPYKCEECGKGFKWPSTLTIHKIIHTGE-------KPYKCEECGKAFNQSSKLTKHK--KIHTGE--KPYTCE 541
Cdd:COG5048  246 SSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCP 325

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 169790765 542 E--CGKAFNQSSNLTKHKRIHTGEKPYKCeecdkafKWSSVLTKHKIIHTGEKLQ 594
Cdd:COG5048  326 YslCGKLFSRNDALKRHILLHTSISPAKE-------KLLNSSSKFSPLLNNEPPQ 373
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
235-489 3.41e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 65.87  E-value: 3.41e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790765 235 CGKAFNQSSNLIKHKKIHTGEKPYKCEECGKTfNRFSTLTTHKIIHTGEKPYKCKECGKAFNRSSTLTTHRKIHTGEKPY 314
Cdd:COG5048  177 SKDPSSNLSLLISSNVSTSIPSSSENSPLSSS-YSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSS 255

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790765 315 KCEECGKAFKQSSNLTTHKIIHTGE-------KPYKCKKCGKAFNQSAHLTTH--EVIHTGE--KPYKC--EKCGKAFNH 381
Cdd:COG5048  256 SASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCpySLCGKLFSR 335

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790765 382 FSHLTTHKIIHTGEKPYKCKECGKAFKHS--------STLTKHKIIHTGEKPYKC-KECEKAFNQSSKLTEHKKIHTGEK 452
Cdd:COG5048  336 NDALKRHILLHTSISPAKEKLLNSSSKFSpllnneppQSLQQYKDLKNDKKSETLsNSCIRNFKRDSNLSLHIITHLSFR 415

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 169790765 453 PYECE--KCGKAFNQSSNLTRHKKSHTEEKPYKCEECGK 489
Cdd:COG5048  416 PYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS 454
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
144-558 2.02e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.09  E-value: 2.02e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790765 144 KIFQCDKYVKVAHKFSNSNRHEIRHTKKKPFKCTK--CGKSFGMISCLTEHSRIHT-RVNFYKCEECGKAFNWSStltKH 220
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHnNPSDLNSKSLPLSNSKAS---SS 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790765 221 KRIHTGEKPYKCE-ECGKAFNQSSNLIKHKKIHTGEKPYKCEECGKTFNRFSTLTTHKIIHTGEKPYKCKEcgkAFNRSS 299
Cdd:COG5048  109 SLSSSSSNSNDNNlLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKD---PSSNLS 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790765 300 TLTTHRKIHTGEKPYKCEECGKA------------FKQSSNLTTHKIIHTGEKPYK---------------CKKCGKAFN 352
Cdd:COG5048  186 LLISSNVSTSIPSSSENSPLSSSysipssssdqnlENSSSSLPLTTNSQLSPKSLLsqspsslsssdssssASESPRSSL 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790765 353 QSAHLTTHEVIHTGE-------KPYKCEKCGKAFNHFSHLTTHK--IIHTGE--KPYKCKE--CGKAFKHSSTLTKHKII 419
Cdd:COG5048  266 PTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILL 345

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790765 420 HTGEKPYKCK--ECEKAFNQSS-----KLTEHKKIHTGEKPYECE--KCGKAFNQSSNLTRHKKSHTEEKPYKCeecgkg 490
Cdd:COG5048  346 HTSISPAKEKllNSSSKFSPLLnneppQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYNC------ 419

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 169790765 491 fkwpstltihkiihtgekpyKCEECGKAFNQSSKLTKHKKIHTGEKPYTCEECGKaFNQSSNLTKHKR 558
Cdd:COG5048  420 --------------------KNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
312-475 1.49e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.40  E-value: 1.49e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790765 312 KPYKCEECGKAFKQSSNLTTHK--IIHTGE--KPYKCKK--CGKAFNQSAHLTTHEVIHTGEKPYKC--EKCGKAFNHFS 383
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLL 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790765 384 ----HLTTHKIIHTGEKPYKC---KECGKAFKHSSTLTKHKIIHTGEKP--YKCKECEKAFNQSSKLTEHKKIHTGEKPY 454
Cdd:COG5048  368 nnepPQSLQQYKDLKNDKKSEtlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447

                        170       180
                 ....*....|....*....|.
gi 169790765 455 ECEKCGKaFNQSSNLTRHKKS 475
Cdd:COG5048  448 LCSILKS-FRRDLDLSNHGKD 467
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 226-306 1.59e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.32  E-value: 1.59e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790765 226 GEKPYKCE--ECGKAFnQSSNLIKHKKIHTGEKPYKCEECGKTfnrfstltTHKIIHTGEKPYKCKECGKAFNRSSTLTT 303
Cdd:COG5189  346 DGKPYKCPveGCNKKY-KNQNGLKYHMLHGHQNQKLHENPSPE--------KMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ...
gi 169790765 304 HRK 306
Cdd:COG5189  417 HRK 419
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 506-585 1.81e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.32  E-value: 1.81e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790765 506 GEKPYKCE--ECGKAFNQSSKLTKHKKiHTGEKPYTCEecgkafnqSSNLTKHKRIHTGEKPYKCEECDKAFKWSSVLTK 583
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHML-HGHQNQKLHE--------NPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ..
gi 169790765 584 HK 585
Cdd:COG5189  417 HR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
552-576 1.87e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.87e-04
                          10        20
                  ....*....|....*....|....*
gi 169790765  552 NLTKHKRIHTGEKPYKCEECDKAFK 576
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 351-477 1.92e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.32  E-value: 1.92e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790765 351 FNQSAHLTTHEVIH-------------TGE------KPYKCEKCGKAFNHFSHLT----THKIIHTGEKPYKCK--ECGK 405
Cdd:COG5189  280 FEESSLGFDYEFIHksvgnkeirggisTGEmidvrkLPCTNSSSNGKLAHGGERNidtpSRMLKVKDGKPYKCPveGCNK 359

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 169790765 406 AFKHSSTLTKHKiihtgekpyKCKECEKAFNQSSKLTEHKKIHTGEKPYECEKCGKAFNQSSNLTRHKKSHT 477
Cdd:COG5189  360 KYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKYHRKHSH 422
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 450-530 2.45e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.94  E-value: 2.45e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790765 450 GEKPYECE--KCGKAFNQSSNLTRHKKsHTEEKPYKCEEcgkgfkwPSTLTiHKIIHTGEKPYKCEECGKAFNQSSKLTK 527
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHML-HGHQNQKLHEN-------PSPEK-MNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ...
gi 169790765 528 HKK 530
Cdd:COG5189  417 HRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
217-241 4.34e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 4.34e-04
                          10        20
                  ....*....|....*....|....*
gi 169790765  217 LTKHKRIHTGEKPYKCEECGKAFNQ 241
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
244-269 4.79e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 4.79e-04
                          10        20
                  ....*....|....*....|....*.
gi 169790765  244 NLIKHKKIHTGEKPYKCEECGKTFNR 269
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
384-409 7.45e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 7.45e-04
                          10        20
                  ....*....|....*....|....*.
gi 169790765  384 HLTTHKIIHTGEKPYKCKECGKAFKH 409
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
328-353 1.30e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.30e-03
                          10        20
                  ....*....|....*....|....*.
gi 169790765  328 NLTTHKIIHTGEKPYKCKKCGKAFNQ 353
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 254-333 1.35e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 1.35e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169790765 254 GEKPYKCE--ECGKTFNRFSTLTTHKiihtgekpyKCKECGKAFNRSSTLTTHRKIHTGEKPYKCEECGKAFKQSSNLTT 331
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ..
gi 169790765 332 HK 333
Cdd:COG5189  417 HR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
301-325 1.37e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.37e-03
                          10        20
                  ....*....|....*....|....*
gi 169790765  301 LTTHRKIHTGEKPYKCEECGKAFKQ 325
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
468-492 1.51e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.51e-03
                          10        20
                  ....*....|....*....|....*
gi 169790765  468 NLTRHKKSHTEEKPYKCEECGKGFK 492
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
525-549 1.63e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.63e-03
                          10        20
                  ....*....|....*....|....*
gi 169790765  525 LTKHKKIHTGEKPYTCEECGKAFNQ 549
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
441-465 1.84e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.84e-03
                          10        20
                  ....*....|....*....|....*
gi 169790765  441 LTEHKKIHTGEKPYECEKCGKAFNQ 465
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
273-297 2.35e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.35e-03
                          10        20
                  ....*....|....*....|....*
gi 169790765  273 LTTHKIIHTGEKPYKCKECGKAFNR 297
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
413-437 2.54e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.54e-03
                          10        20
                  ....*....|....*....|....*
gi 169790765  413 LTKHKIIHTGEKPYKCKECEKAFNQ 437
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
356-381 4.54e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.54e-03
                          10        20
                  ....*....|....*....|....*.
gi 169790765  356 HLTTHEVIHTGEKPYKCEKCGKAFNH 381
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
497-521 5.01e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 5.01e-03
                          10        20
                  ....*....|....*....|....*
gi 169790765  497 LTIHKIIHTGEKPYKCEECGKAFNQ 521
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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