NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|4505353|ref|NP_003626|]
View 

bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2 isoform 1 [Homo sapiens]

Protein Classification

bifunctional heparan sulfate N-deacetylase/N-sulfotransferase( domain architecture ID 10572471)

bifunctional heparan sulfate N-deacetylase/N-sulfotransferase catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
HSNSD pfam12062
heparan sulfate-N-deacetylase; This family of proteins is are heparan sulfate N-deacetylase ...
 83-514 0e+00

heparan sulfate-N-deacetylase; This family of proteins is are heparan sulfate N-deacetylase enzymes. This protein is found in eukaryotes. This proteinenzyme is often found associated with pfam00685.


:

Pssm-ID: 463450  Cd Length: 429  Bit Score: 883.96  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505353     83 TEPVVLVFVESAYSQLGQEIVAILESSRFRYSTELApgRGDMPTLTDNTHGRYVLVIYENLLKYVNLDAWSRELLDRYCV 162
Cdd:pfam12062   1 TDPKVLVFVESLYSQLGQEIIAILESNRFKYKTEIA--KKDLPVLTNKDKGRYSLIIYENYLKYLNMDKWNRELLDKYCR 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505353    163 EYGVGIIGFFRAHEHSLLSAQLKGFPLFLHSNLGLRDYQVNPSAPLLHLTRPSRLEPGPLPGDDWTIFQSNHSTYEPVLL 242
Cdd:pfam12062  79 EYGVGIIGFFKANENSLLSAQLKGFPLFLHTNLRLKDCTVNPKSPLLRITRPGEVEQGPLPGDDWTVFQSNHSTYEPVLL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505353    243 ASLRPAEPAvPGPVLRRARLPTVVQDLGLHDGIQRVLFGHGLSFWLHKLIFVDAVAYLTGKRLCLDLDRYILVDIDDIFV 322
Cdd:pfam12062 159 AKVKSGEES-PSPGLDAALLATVVQDLGLHDGIQRVLFGNNLNFWLHKLVFLDALSYLTGKRLSLSLDRYILVDIDDIFV 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505353    323 GKEGTRMKVADVEALLTTQNKLRTLVPNFTFNLGFSGKFYHTGTEEEDAGDDMLLKHRKEFWWFPHMWSHMQPHLFHNRS 402
Cdd:pfam12062 238 GKEGTRMKVEDVKALLETQNRLRTLVPNFTFNLGFSGKYFHNGTDEEDEGDDLLLENVKEFWWFPHMWSHMQPHLFHNQT 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505353    403 VLADQMRLNKQFALEHGIPTDLGYAVAPHHSGVYPIHTQLYEAWKSVWGIQVTSTEEYPHLRPARYRRGFIHNGIMVLPR 482
Cdd:pfam12062 318 VLEEQMLLNKKFAQEHGIPTDSGYAVAPHHSGVYPVHEQLYEAWKKVWNIKVTSTEEYPHLKPARLRRGFIHRGIMVLPR 397

                         410       420       430
                  ....*....|....*....|....*....|..
gi 4505353    483 QTCGLFTHTIFYNEYPGGSRELDRSIRGGELF 514
Cdd:pfam12062 398 QTCGLFTHTIFYDEYPGGPKKLDKSIQGGELF 429
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
603-852 7.18e-45

Sulfotransferase domain;


:

Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 162.13  E-value: 7.18e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505353    603 LPKFLIVGPQKTGTTAIHFFLSLHPAVTSSFPSpstfEEIQFFNSPNYHKGIDWYMDFFPVPSNASTDFLFEKS-----A 677
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKS----EEPHLFNNHNRSPFLEWYPGDTYFDVAEGPVRLNALPspriiK 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505353    678 TYFDSEVVPRrgAALLPRAKIITVLTNPADRAYSWYQHQRAHGDPVALNYTFYQVisassqtplalRSLQNRCLVPGYYS 757
Cdd:pfam00685  77 THLPLHLLPK--SLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFV-----------EDFLNGKVNCGSYF 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505353    758 THLQRWLTYYPSGQLLIVDGQELRTNPAASMESIQKFLGITP----FLNYTRTLRFDDDKGFWCQGL-------EGGKTR 826
Cdd:pfam00685 144 DHVKGWWKLRPPGNILFLRYEDLKKDPRGEIKKIAEFLGIPLteeeLDKIVKHLSFENMKGNPCLNYsklpkevSPFFRK 223

                         250       260
                  ....*....|....*....|....*.
gi 4505353    827 CLGRSKgrrYPDMDTESRLFLTDFFR 852
Cdd:pfam00685 224 GLVGDW---KNYFTPEQAEKFDEIYQ 246
 
Name Accession Description Interval E-value
HSNSD pfam12062
heparan sulfate-N-deacetylase; This family of proteins is are heparan sulfate N-deacetylase ...
 83-514 0e+00

heparan sulfate-N-deacetylase; This family of proteins is are heparan sulfate N-deacetylase enzymes. This protein is found in eukaryotes. This proteinenzyme is often found associated with pfam00685.


Pssm-ID: 463450  Cd Length: 429  Bit Score: 883.96  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505353     83 TEPVVLVFVESAYSQLGQEIVAILESSRFRYSTELApgRGDMPTLTDNTHGRYVLVIYENLLKYVNLDAWSRELLDRYCV 162
Cdd:pfam12062   1 TDPKVLVFVESLYSQLGQEIIAILESNRFKYKTEIA--KKDLPVLTNKDKGRYSLIIYENYLKYLNMDKWNRELLDKYCR 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505353    163 EYGVGIIGFFRAHEHSLLSAQLKGFPLFLHSNLGLRDYQVNPSAPLLHLTRPSRLEPGPLPGDDWTIFQSNHSTYEPVLL 242
Cdd:pfam12062  79 EYGVGIIGFFKANENSLLSAQLKGFPLFLHTNLRLKDCTVNPKSPLLRITRPGEVEQGPLPGDDWTVFQSNHSTYEPVLL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505353    243 ASLRPAEPAvPGPVLRRARLPTVVQDLGLHDGIQRVLFGHGLSFWLHKLIFVDAVAYLTGKRLCLDLDRYILVDIDDIFV 322
Cdd:pfam12062 159 AKVKSGEES-PSPGLDAALLATVVQDLGLHDGIQRVLFGNNLNFWLHKLVFLDALSYLTGKRLSLSLDRYILVDIDDIFV 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505353    323 GKEGTRMKVADVEALLTTQNKLRTLVPNFTFNLGFSGKFYHTGTEEEDAGDDMLLKHRKEFWWFPHMWSHMQPHLFHNRS 402
Cdd:pfam12062 238 GKEGTRMKVEDVKALLETQNRLRTLVPNFTFNLGFSGKYFHNGTDEEDEGDDLLLENVKEFWWFPHMWSHMQPHLFHNQT 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505353    403 VLADQMRLNKQFALEHGIPTDLGYAVAPHHSGVYPIHTQLYEAWKSVWGIQVTSTEEYPHLRPARYRRGFIHNGIMVLPR 482
Cdd:pfam12062 318 VLEEQMLLNKKFAQEHGIPTDSGYAVAPHHSGVYPVHEQLYEAWKKVWNIKVTSTEEYPHLKPARLRRGFIHRGIMVLPR 397

                         410       420       430
                  ....*....|....*....|....*....|..
gi 4505353    483 QTCGLFTHTIFYNEYPGGSRELDRSIRGGELF 514
Cdd:pfam12062 398 QTCGLFTHTIFYDEYPGGPKKLDKSIQGGELF 429
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
603-852 7.18e-45

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 162.13  E-value: 7.18e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505353    603 LPKFLIVGPQKTGTTAIHFFLSLHPAVTSSFPSpstfEEIQFFNSPNYHKGIDWYMDFFPVPSNASTDFLFEKS-----A 677
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKS----EEPHLFNNHNRSPFLEWYPGDTYFDVAEGPVRLNALPspriiK 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505353    678 TYFDSEVVPRrgAALLPRAKIITVLTNPADRAYSWYQHQRAHGDPVALNYTFYQVisassqtplalRSLQNRCLVPGYYS 757
Cdd:pfam00685  77 THLPLHLLPK--SLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFV-----------EDFLNGKVNCGSYF 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505353    758 THLQRWLTYYPSGQLLIVDGQELRTNPAASMESIQKFLGITP----FLNYTRTLRFDDDKGFWCQGL-------EGGKTR 826
Cdd:pfam00685 144 DHVKGWWKLRPPGNILFLRYEDLKKDPRGEIKKIAEFLGIPLteeeLDKIVKHLSFENMKGNPCLNYsklpkevSPFFRK 223

                         250       260
                  ....*....|....*....|....*.
gi 4505353    827 CLGRSKgrrYPDMDTESRLFLTDFFR 852
Cdd:pfam00685 224 GLVGDW---KNYFTPEQAEKFDEIYQ 246
 
Name Accession Description Interval E-value
HSNSD pfam12062
heparan sulfate-N-deacetylase; This family of proteins is are heparan sulfate N-deacetylase ...
 83-514 0e+00

heparan sulfate-N-deacetylase; This family of proteins is are heparan sulfate N-deacetylase enzymes. This protein is found in eukaryotes. This proteinenzyme is often found associated with pfam00685.


Pssm-ID: 463450  Cd Length: 429  Bit Score: 883.96  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505353     83 TEPVVLVFVESAYSQLGQEIVAILESSRFRYSTELApgRGDMPTLTDNTHGRYVLVIYENLLKYVNLDAWSRELLDRYCV 162
Cdd:pfam12062   1 TDPKVLVFVESLYSQLGQEIIAILESNRFKYKTEIA--KKDLPVLTNKDKGRYSLIIYENYLKYLNMDKWNRELLDKYCR 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505353    163 EYGVGIIGFFRAHEHSLLSAQLKGFPLFLHSNLGLRDYQVNPSAPLLHLTRPSRLEPGPLPGDDWTIFQSNHSTYEPVLL 242
Cdd:pfam12062  79 EYGVGIIGFFKANENSLLSAQLKGFPLFLHTNLRLKDCTVNPKSPLLRITRPGEVEQGPLPGDDWTVFQSNHSTYEPVLL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505353    243 ASLRPAEPAvPGPVLRRARLPTVVQDLGLHDGIQRVLFGHGLSFWLHKLIFVDAVAYLTGKRLCLDLDRYILVDIDDIFV 322
Cdd:pfam12062 159 AKVKSGEES-PSPGLDAALLATVVQDLGLHDGIQRVLFGNNLNFWLHKLVFLDALSYLTGKRLSLSLDRYILVDIDDIFV 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505353    323 GKEGTRMKVADVEALLTTQNKLRTLVPNFTFNLGFSGKFYHTGTEEEDAGDDMLLKHRKEFWWFPHMWSHMQPHLFHNRS 402
Cdd:pfam12062 238 GKEGTRMKVEDVKALLETQNRLRTLVPNFTFNLGFSGKYFHNGTDEEDEGDDLLLENVKEFWWFPHMWSHMQPHLFHNQT 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505353    403 VLADQMRLNKQFALEHGIPTDLGYAVAPHHSGVYPIHTQLYEAWKSVWGIQVTSTEEYPHLRPARYRRGFIHNGIMVLPR 482
Cdd:pfam12062 318 VLEEQMLLNKKFAQEHGIPTDSGYAVAPHHSGVYPVHEQLYEAWKKVWNIKVTSTEEYPHLKPARLRRGFIHRGIMVLPR 397

                         410       420       430
                  ....*....|....*....|....*....|..
gi 4505353    483 QTCGLFTHTIFYNEYPGGSRELDRSIRGGELF 514
Cdd:pfam12062 398 QTCGLFTHTIFYDEYPGGPKKLDKSIQGGELF 429
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
603-852 7.18e-45

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 162.13  E-value: 7.18e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505353    603 LPKFLIVGPQKTGTTAIHFFLSLHPAVTSSFPSpstfEEIQFFNSPNYHKGIDWYMDFFPVPSNASTDFLFEKS-----A 677
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKS----EEPHLFNNHNRSPFLEWYPGDTYFDVAEGPVRLNALPspriiK 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505353    678 TYFDSEVVPRrgAALLPRAKIITVLTNPADRAYSWYQHQRAHGDPVALNYTFYQVisassqtplalRSLQNRCLVPGYYS 757
Cdd:pfam00685  77 THLPLHLLPK--SLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFV-----------EDFLNGKVNCGSYF 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505353    758 THLQRWLTYYPSGQLLIVDGQELRTNPAASMESIQKFLGITP----FLNYTRTLRFDDDKGFWCQGL-------EGGKTR 826
Cdd:pfam00685 144 DHVKGWWKLRPPGNILFLRYEDLKKDPRGEIKKIAEFLGIPLteeeLDKIVKHLSFENMKGNPCLNYsklpkevSPFFRK 223

                         250       260
                  ....*....|....*....|....*.
gi 4505353    827 CLGRSKgrrYPDMDTESRLFLTDFFR 852
Cdd:pfam00685 224 GLVGDW---KNYFTPEQAEKFDEIYQ 246
Sulfotransfer_3 pfam13469
Sulfotransferase family;
608-798 1.12e-13

Sulfotransferase family;


Pssm-ID: 463887  Cd Length: 173  Bit Score: 70.01  E-value: 1.12e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505353    608 IVGPQKTGTTAIHFFLSLHPAVtssfPSPSTFEEIQFFNSPNYHKGIDWYMDFFPVPSNAstDFLFEKSATYFDS-EVVp 686
Cdd:pfam13469   3 IVGLPRSGTTLLHRLLAAHPDV----RPPEETWFVIPRILALLQAWGKSLEALARVPSYA--RWLCDKSPSHLFHlDLL- 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505353    687 rrgAALLPRAKIITVLTNPADRAYSWYQHqrahgdpvalnytfyqvISASSQTPLALRSLQNRCLVPGYYSTHLQRWLT- 765
Cdd:pfam13469  76 ---LKAFPDAKFIHLHRDPVDTVISSYCS-----------------LFGFTLSSYSTAFLRDIGLALARWSRAYERLMAa 135

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 4505353    766 --YYPSGQLLIVDGQELRTNPAASMESIQKFLGIT 798
Cdd:pfam13469 136 raRVPPGRFLDVRYEDLVADPEGTLRRILEFLGLP 170
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH