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Conserved domains on  [gi|126012573|ref|NP_004516|]
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low-density lipoprotein receptor-related protein 2 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3759-3793 3.35e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 60.68  E-value: 3.35e-11
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 126012573 3759 CTESEFRCVNQQCIPSRWICDHYNDCGDNSDERDC 3793
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3719-3754 9.52e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 59.14  E-value: 9.52e-11
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 126012573 3719 CHPvGDFRCKNHHCIPLRWQCDGQNDCGDNSDEENC 3754
Cdd:cd00112     1 CPP-NEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2905-2937 1.32e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


:

Pssm-ID: 197566  Cd Length: 33  Bit Score: 58.80  E-value: 1.32e-10
                            10        20        30
                    ....*....|....*....|....*....|...
gi 126012573   2905 TCLADEFKCDGGRCIPSEWICDGDNDCGDMSDE 2937
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1501-1543 1.55e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 58.77  E-value: 1.55e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 126012573   1501 RVVFDSSIILTETIAIDWVGRNLYWTDYALETIEVSKIDGSHR 1543
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3634-3666 2.46e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


:

Pssm-ID: 197566  Cd Length: 33  Bit Score: 58.03  E-value: 2.46e-10
                            10        20        30
                    ....*....|....*....|....*....|...
gi 126012573   3634 TCRPGQFRCANGRCIPQAWKCDVDNDCGDHSDE 3666
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 3358-3399 2.55e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 58.38  E-value: 2.55e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 126012573   3358 VIISTKLEWPNGITIDYTNDLLYWADAHLGYIEYSDLEGHHR 3399
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1271-1305 2.84e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 57.99  E-value: 2.84e-10
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 126012573 1271 CPSSYFHCDNGNCIHRAWLCDRDNDCGDMSDEKDC 1305
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1109-1143 3.05e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 57.99  E-value: 3.05e-10
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 126012573 1109 CLDTQYTCDNHQCISKNWVCDTDNDCGDGSDEKNC 1143
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1149-1183 3.26e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 57.60  E-value: 3.26e-10
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 126012573 1149 CQPSQFNCPNHRCIDLSFVCDGDKDCVDGSDEVGC 1183
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 183-217 3.78e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 57.60  E-value: 3.78e-10
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 126012573  183 CLHNEFSCGNGECIPRAYVCDHDNDCQDGSDEHAC 217
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 503-548 5.21e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 57.23  E-value: 5.21e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 126012573    503 TLITENLGHPRGIAVDPTVGYLFFSDWeslsGEPKLERAFMDGSNR 548
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDW----GLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 864-904 5.47e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 57.23  E-value: 5.47e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 126012573    864 VINTTLGWPNGLAIDWAASRLYWVDAYFDKIEHSTFDGLDR 904
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1545-1589 6.15e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 57.23  E-value: 6.15e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 126012573   1545 VLISKNLTNPRGLALDPRmnEHLLFWSDWGhHPRIERASMDGSMR 1589
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWI--EGRLYWTDWG-LDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 4141-4176 8.01e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 56.84  E-value: 8.01e-10
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 126012573   4141 VMQPDGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYR 4176
Cdd:smart00135    8 LGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2993-3027 8.25e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 56.45  E-value: 8.25e-10
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 126012573 2993 CSENEFTCGYGLCIPKIFRCDRHNDCGDYSDERGC 3027
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 4197-4238 1.42e-09

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 56.01  E-value: 1.42e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 126012573  4197 GLMFWTDWGKEPKIESAWMNGEDRNILVFEDLGWPTGLSIDY 4238
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1067-1101 1.64e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 55.68  E-value: 1.64e-09
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 126012573 1067 CSSSAFTCGHGECIPAHWRCDKRNDCVDGSDEHNC 1101
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3031-3063 2.29e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


:

Pssm-ID: 197566  Cd Length: 33  Bit Score: 55.33  E-value: 2.29e-09
                            10        20        30
                    ....*....|....*....|....*....|...
gi 126012573   3031 TCQQNQFTCQNGRCISKTFVCDEDNDCGDGSDE 3063
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 3333-3374 2.87e-09

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 55.24  E-value: 2.87e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 126012573  3333 GYLYWADWGHRAYIGRVGMDGTNKSVIISTKLEWPNGITIDY 3374
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3075-3109 2.91e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 54.91  E-value: 2.91e-09
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 126012573 3075 CPPHEFKCDNGRCIEMMKLCNHLDDCLDNSDEKGC 3109
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 222-256 3.06e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 54.91  E-value: 3.06e-09
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 126012573  222 CGGYQFTCPSGRCIYQNWVCDGEDDCKDNGDEDGC 256
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 4222-4264 3.12e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 55.30  E-value: 3.12e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 126012573   4222 ILVFEDLGWPTGLSIDYLNnDRIYWSDFKEDVIETIKYDGTDR 4264
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIE-GRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2741-2775 3.61e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 54.91  E-value: 3.61e-09
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 126012573 2741 CSPTAFTCANGRCVQYSYRCDYYNDCGDGSDEAGC 2775
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 28-62 3.68e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 54.91  E-value: 3.68e-09
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 126012573   28 CDSAHFRCGSGHCIPADWRCDGTKDCSDDADEIGC 62
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2700-2732 4.18e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 54.52  E-value: 4.18e-09
                          10        20        30
                  ....*....|....*....|....*....|...
gi 126012573 2700 CGASSFTCSNGRCISEEWKCDNDNDCGDGSDEM 2732
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3928-3962 6.50e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 54.13  E-value: 6.50e-09
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 126012573 3928 CTEYEYKCGNGHCIPHDNVCDDADDCGDWSDELGC 3962
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 108-142 7.90e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 53.75  E-value: 7.90e-09
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 126012573  108 CSSHQITCSNGQCIPSEYRCDHVRDCPDGADENDC 142
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3594-3626 8.55e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 53.75  E-value: 8.55e-09
                          10        20        30
                  ....*....|....*....|....*....|...
gi 126012573 3594 CDSNEWQCANKRCIPESWQCDTFNDCEDNSDED 3626
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
2863-2895 1.34e-08

Low-density lipoprotein receptor domain class A;


:

Pssm-ID: 395011  Cd Length: 37  Bit Score: 53.41  E-value: 1.34e-08
                           10        20        30
                   ....*....|....*....|....*....|...
gi 126012573  2863 TCSSSEFQCASGRCIPQHWYCDQETDCFDASDE 2895
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 2545-2585 1.41e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 53.37  E-value: 1.41e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 126012573   2545 IVNSSLVMPSGLTLDYEEDLLYWVDASLQRIERSTLTGVDR 2585
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1026-1060 1.46e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 52.98  E-value: 1.46e-08
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 126012573 1026 CGLFSFPCKNGRCVPNYYLCDGVDDCHDNSDEQLC 1060
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3512-3544 2.49e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


:

Pssm-ID: 197566  Cd Length: 33  Bit Score: 52.25  E-value: 2.49e-08
                            10        20        30
                    ....*....|....*....|....*....|...
gi 126012573   3512 CSSTQFLCANNeKCIPIWWKCDGQKDCSDGSDE 3544
Cdd:smart00192    2 CPPGEFQCDNG-RCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 551-591 2.66e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 52.60  E-value: 2.66e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 126012573    551 LVKTKLGWPAGVTLDMISKRVYWVDSRFDYIETVTYDGIQR 591
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 3262-3304 6.30e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 51.45  E-value: 6.30e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 126012573   3262 ETIINHRLPAAESLAVDWVSRKLYWLDARLDGLFVSDLNGGHR 3304
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3798-3832 6.48e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 51.05  E-value: 6.48e-08
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 126012573 3798 CHPEYFQCTSGHCVHSELKCDGSADCLDASDEADC 3832
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 776-818 7.37e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 51.45  E-value: 7.37e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 126012573    776 EILAANRVENVESLAFDWISKNLYWTDSHYKSISVMRLADKTR 818
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1883-1928 8.67e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 51.01  E-value: 8.67e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 126012573  1883 GKLYWsdqgTDSGVPAKIASANMDGTSVKTLFTGNLEHLECVTLDI 1928
Cdd:pfam00058    1 GRLYW----TDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 2227-2267 1.30e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 50.68  E-value: 1.30e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 126012573   2227 VLVSEGIVTPRGLAVDRSDGYVYWVDDSLDIIARIRINGEN 2267
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
2091-2252 1.38e-07

DNA-binding beta-propeller fold protein YncE [General function prediction only];


:

Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 55.86  E-value: 1.38e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012573 2091 AGQGRNALHVDVDVSSGFIYWCDfsssvASDNAIRRIKPDGSSLMNIVTHGigeNGVRGIAVDWVAGNLYFTNAFVSEtl 2170
Cdd:COG3391    64 AAAVADADGADAGADGRRLYVAN-----SGSGRVSVIDLATGKVVATIPVG---GGPRGLAVDPDGGRLYVADSGNGR-- 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012573 2171 ieVLRINTTYRRVLLKVTV-DMPRHIVVDPKNRYLFWADYGQrPKIER--SFLDCTNRTVL--VSEGiVTPRGLAVDRSD 2245
Cdd:COG3391   134 --VSVIDTATGKVVATIPVgAGPHGIAVDPDGKRLYVANSGS-NTVSVivSVIDTATGKVVatIPVG-GGPVGVAVSPDG 209


                  ....*..
gi 126012573 2246 GYVYWVD 2252
Cdd:COG3391   210 RRLYVAN 216
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 838-879 1.51e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 50.24  E-value: 1.51e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 126012573   838 GYLFFTDWFRPAKIMRAWSDGSHLLPVINTTLGWPNGLAIDW 879
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1187-1222 3.23e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 49.13  E-value: 3.23e-07
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 126012573 1187 CTASQFKCASGdKCIGVTNRCDGVFDCSDNSDEAGC 1222
Cdd:cd00112     1 CPPNEFRCANG-RCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2948-2988 4.33e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 48.74  E-value: 4.33e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 126012573 2948 CSDSEFLCVNdrppdRRCIPQSWVCDGDVDCTDGYDEnQNC 2988
Cdd:cd00112     1 CPPNEFRCAN-----GRCIPSSWVCDGEDDCGDGSDE-ENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 2459-2500 5.38e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 48.75  E-value: 5.38e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 126012573   2459 TVIASGIGTADGIAFDWITRRIYYSDYLNQMINSMAEDGSNR 2500
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 3219-3260 6.36e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 48.75  E-value: 6.36e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 126012573   3219 YSLILEGLDNVVALDFDRVEKRLYWIDTQRQVIERMFLNKTN 3260
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1230-1264 7.00e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 48.36  E-value: 7.00e-07
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 126012573 1230 CHSDEFQCQeDGICIPNFWECDGHPDCLYGSDEHN 1264
Cdd:cd00112     1 CPPNEFRCA-NGRCIPSSWVCDGEDDCGDGSDEEN 34
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3682-3714 9.11e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 47.97  E-value: 9.11e-07
                          10        20        30
                  ....*....|....*....|....*....|...
gi 126012573 3682 TEFSCKtNYRCIPKWAVCNGVDDCRDNSDEQGC 3714
Cdd:cd00112     4 NEFRCA-NGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1591-1632 1.01e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 47.98  E-value: 1.01e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 126012573   1591 VIVQDKIFWPCGLTIDYPNRLLYFMDSYLDYMDFCDYNGHHR 1632
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3885-3915 1.36e-06

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


:

Pssm-ID: 197566  Cd Length: 33  Bit Score: 47.63  E-value: 1.36e-06
                            10        20        30
                    ....*....|....*....|....*....|.
gi 126012573   3885 SPNRFRCDNNRCIYSHEVCNGVDDCGDGTDE 3915
Cdd:smart00192    3 PPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_b super family cl44468
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 3282-3330 1.58e-06

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


The actual alignment was detected with superfamily member pfam00058:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 47.54  E-value: 1.58e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 126012573  3282 RKLYWLDARLD-GLFVSDLNGGHRRMLAQHcvdanntfCFDNPRGLALHP 3330
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTD--------DLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 2500-2542 1.66e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 47.60  E-value: 1.66e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 126012573   2500 RTVIAR-VPKPRAIVLDPCQGYLYWADWDTHaKIERATLGGNFR 2542
Cdd:smart00135    1 RTLLSSgLGHPNGLAVDWIEGRLYWTDWGLD-VIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1911-1953 1.96e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 47.21  E-value: 1.96e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 126012573   1911 KTLFTGNLEHLECVTLDIEEQKLYWAVTGRGVIERGNVDGTDR 1953
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1353-1388 3.24e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 46.47  E-value: 3.24e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 126012573  1353 CSDFNGGCTHECVQEPFGAKCLCPLGFLLANDSKTC 1388
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 2022-2058 4.06e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 46.08  E-value: 4.06e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 126012573  2022 CSNNMNACQQICLPVPGGlFSCACATGFKLNPDNRSC 2058
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGG-YTCSCPEGYELQDDGRTC 36
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2784-2817 4.37e-06

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 46.05  E-value: 4.37e-06
                          10        20        30
                  ....*....|....*....|....*....|....
gi 126012573 2784 TEFMCNNRRCIPREFICNGVDNCHDNntSDEKNC 2817
Cdd:cd00112     4 NEFRCANGRCIPSSWVCDGEDDCGDG--SDEENC 35
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
394-579 4.88e-06

DNA-binding beta-propeller fold protein YncE [General function prediction only];


:

Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 51.23  E-value: 4.88e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012573  394 ASIIFSNGRDLLIGDIHGRSFRILVESQNRGVAVGVAFHYHL--QRVFWTDTVQNKVFSVDINGLNIQEVLNVSVEtPEN 471
Cdd:COG3391    36 LLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGAdgRRLYVANSGSGRVSVIDLATGKVVATIPVGGG-PRG 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012573  472 LAVDWVNNKIYLVETKVNRIDMVNL-DGSYRVTLITENlgHPRGIAVDPTVGYLFFSDWeslsGEPKLER--AFMDGSNR 548
Cdd:COG3391   115 LAVDPDGGRLYVADSGNGRVSVIDTaTGKVVATIPVGA--GPHGIAVDPDGKRLYVANS----GSNTVSVivSVIDTATG 188

                         170       180       190
                  ....*....|....*....|....*....|..
gi 126012573  549 KDLVKTKLG-WPAGVTLDMISKRVYWVDSRFD 579
Cdd:COG3391   189 KVVATIPVGgGPVGVAVSPDGRRLYVANRGSN 220
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2821-2854 6.11e-06

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


:

Pssm-ID: 197566  Cd Length: 33  Bit Score: 45.70  E-value: 6.11e-06
                            10        20        30
                    ....*....|....*....|....*....|....
gi 126012573   2821 TCQSGYTKCHNSNiCIPRVYLCDGDNDCGDNSDE 2854
Cdd:smart00192    1 TCPPGEFQCDNGR-CIPSSWVCDGVDDCGDGSDE 33
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 3121-3150 7.04e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 45.31  E-value: 7.04e-06
                           10        20        30
                   ....*....|....*....|....*....|
gi 126012573  3121 GCDHNCTDTLTSFYCSCRPGYKLMSDKRTC 3150
Cdd:pfam14670    7 GCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
Vgb super family cl26743
Streptogramin lyase [Defense mechanisms];
2236-2544 9.15e-06

Streptogramin lyase [Defense mechanisms];


The actual alignment was detected with superfamily member COG4257:

Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 50.79  E-value: 9.15e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012573 2236 PRGLAVDRsDGYVYWVDDSLDIIARIRINGENSEVIRYGSRyPTPYGITVFENSIIWV-DRNLKKIFQaskepenteppt 2314
Cdd:COG4257    19 PRDVAVDP-DGAVWFTDQGGGRIGRLDPATGEFTEYPLGGG-SGPHGIAVDPDGNLWFtDNGNNRIGR------------ 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012573 2315 virdninwlrdVTIFDKQVQprspaevnnnpclennggcshlCFALPGLHTPKCDCAFGtlqSDGKncaistenfLIFAL 2394
Cdd:COG4257    85 -----------IDPKTGEIT----------------------TFALPGGGSNPHGIAFD---PDGN---------LWFTD 119

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012573 2395 SNSLRSLHLDPENHSppFQTINVERTV---MSLDYDSvSDRIYFTQNLASGVGQISYATLSSGIHT-PTVIA--SGIG-T 2467
Cdd:COG4257   120 QGGNRIGRLDPATGE--VTEFPLPTGGagpYGIAVDP-DGNLWVTDFGANAIGRIDPDTGTLTEYAlPTPGAgpRGLAvD 196

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012573 2468 ADGiafdwitrRIYYSDYLN---QMINsmAEDGSNRTVI--ARVPKPRAIVLDPcQGYLYWADWDTH--AKIERATLGGN 2540
Cdd:COG4257   197 PDG--------NLWVADTGSgriGRFD--PKTGTVTEYPlpGGGARPYGVAVDG-DGRVWFAESGANriVRFDPDTELTE 265


                  ....
gi 126012573 2541 FRVP 2544
Cdd:COG4257   266 YVLP 269
EGF_CA smart00179
Calcium-binding EGF-like domain;
4007-4047 1.27e-05

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.93  E-value: 1.27e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 126012573   4007 DINECEQFGTCPQH--CRNTKGSYECVCADGFTSmsdrpGKRC 4047
Cdd:smart00179    1 DIDECASGNPCQNGgtCVNTVGSYRCECPPGYTD-----GRNC 38
vWFA super family cl00057
Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation ...
 3147-3190 2.09e-05

Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains.


The actual alignment was detected with superfamily member cd01475:

Pssm-ID: 469594 [Multi-domain]  Cd Length: 224  Bit Score: 48.92  E-value: 2.09e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 126012573 3147 KRTCVDIDECTEMPFVCSQKCENVIGSYICKCAPGYLREPDGKT 3190
Cdd:cd01475   181 GKICVVPDLCATLSHVCQQVCISTPGSYLCACTEGYALLEDNKT 224
EGF_CA smart00179
Calcium-binding EGF-like domain;
1390-1429 5.13e-05

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.00  E-value: 5.13e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 126012573   1390 DIDECDILGSCSQH--CYNMRGSFRCSCDTGYmleSDGRTCK 1429
Cdd:smart00179    1 DIDECASGNPCQNGgtCVNTVGSYRCECPPGY---TDGRNCE 39
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 266-300 1.53e-04

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 41.81  E-value: 1.53e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 126012573  266 CSPREWSCPeSGRCISIYKVCDGILDCPGREDENN 300
Cdd:cd00112     1 CPPNEFRCA-NGRCIPSSWVCDGEDDCGDGSDEEN 34
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3553-3584 1.54e-04

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


:

Pssm-ID: 197566  Cd Length: 33  Bit Score: 41.46  E-value: 1.54e-04
                            10        20        30
                    ....*....|....*....|....*....|..
gi 126012573   3553 CRLGQFQCSDGNCTSPQTLCNAHQNCPDGSDE 3584
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 149-179 1.77e-04

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 41.42  E-value: 1.77e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 126012573  149 QLTCDNGACYNTSQKCDWKVDCRDSSDEINC 179
Cdd:cd00112     5 EFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 3408-3441 2.30e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 41.43  E-value: 2.30e-04
                            10        20        30
                    ....*....|....*....|....*....|....
gi 126012573   3408 PHPFAITIFEDTIYWTDWNTRTVEKgNKYDGSNR 3441
Cdd:smart00135   11 PNGLAVDWIEGRLYWTDWGLDVIEV-ANLDGTNR 43
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 3469-3498 4.26e-04

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 40.30  E-value: 4.26e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 126012573  3469 CGTNNGGCSHLCLIKPGgkGFTCECPDDFR 3498
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPG--GYTCSCPEGYE 28
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1311-1344 9.20e-04

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


:

Pssm-ID: 197566  Cd Length: 33  Bit Score: 39.54  E-value: 9.20e-04
                            10        20        30
                    ....*....|....*....|....*....|....
gi 126012573   1311 RCPSWQWQClGHNICVNLSVVCDGIFDCPNGTDE 1344
Cdd:smart00192    1 TCPPGEFQC-DNGRCIPSSWVCDGVDDCGDGSDE 33
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 981-1013 1.00e-03

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 39.53  E-value: 1.00e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 126012573   981 NGDCSHFCFPVPNfQRVCGCPYGMRLASNHLTC 1013
Cdd:pfam14670    5 NGGCSHLCLNTPG-GYTCSCPEGYELQDDGRTC 36
YvrE super family cl34598
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 1787-1951 1.18e-03

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


The actual alignment was detected with superfamily member COG3386:

Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 44.11  E-value: 1.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012573 1787 DAEQYIYWVENP-GEIHRVKTDGTNRTVFASISmvGPSMNLALD-----WI---SRNLYSTNPRTQSIEVLTLHGDIRYR 1857
Cdd:COG3386    16 DPDGRLYWVDIPgGRIHRYDPDGGAVEVFAEPS--GRPNGLAFDpdgrlLVadhGRGLVRFDPADGEVTVLADEYGKPLN 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012573 1858 ktlIANDGtalgvgfpigiTVDPArGKLYWSDQGTDSGvPAKIASANMDGtSVKTLFTG----N-LehleCVTLDieEQK 1932
Cdd:COG3386    94 ---RPNDG-----------VVDPD-GRLYFTDMGEYLP-TGALYRVDPDG-SLRVLADGltfpNgI----AFSPD--GRT 150

                         170
                  ....*....|....*....
gi 126012573 1933 LYWAVTGRGVIERGNVDGT 1951
Cdd:COG3386   151 LYVADTGAGRIYRFDLDAD 169
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 2655-2692 1.40e-03

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 39.15  E-value: 1.40e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 126012573  2655 CEQFNGGCSHICAPGPNGAECQCPHEgnWYLANNRKHC 2692
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEG--YELQDDGRTC 36
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 663-704 1.96e-03

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 38.76  E-value: 1.96e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 126012573   663 CKDNNGGCEQVCVlshrtdNDGLGFRCKCTFGFQLDTDERHC 704
Cdd:pfam14670    1 CSVNNGGCSHLCL------NTPGGYTCSCPEGYELQDDGRTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1461-1500 2.99e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 38.35  E-value: 2.99e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 126012573   1461 LVENGSYIVAVDFDSISGRIFWSDATQGKTWSAFQNGTDR 1500
Cdd:smart00135    4 LSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 2593-2625 5.90e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 37.58  E-value: 5.90e-03
                            10        20        30
                    ....*....|....*....|....*....|...
gi 126012573   2593 VHAFGLTLYGQYIYWTDLYTQRIYRANkYDGSG 2625
Cdd:smart00135   11 PNGLAVDWIEGRLYWTDWGLDVIEVAN-LDGTN 42
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 4338-4356 6.96e-03

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 37.22  E-value: 6.96e-03
                           10
                   ....*....|....*....
gi 126012573  4338 CSHLCLLRPGGYSCACPQG 4356
Cdd:pfam14670    8 CSHLCLNTPGGYTCSCPEG 26
 
Name Accession Description Interval E-value
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3759-3793 3.35e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 60.68  E-value: 3.35e-11
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 126012573 3759 CTESEFRCVNQQCIPSRWICDHYNDCGDNSDERDC 3793
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3719-3754 9.52e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 59.14  E-value: 9.52e-11
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 126012573 3719 CHPvGDFRCKNHHCIPLRWQCDGQNDCGDNSDEENC 3754
Cdd:cd00112     1 CPP-NEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2905-2937 1.32e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 58.80  E-value: 1.32e-10
                            10        20        30
                    ....*....|....*....|....*....|...
gi 126012573   2905 TCLADEFKCDGGRCIPSEWICDGDNDCGDMSDE 2937
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1501-1543 1.55e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 58.77  E-value: 1.55e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 126012573   1501 RVVFDSSIILTETIAIDWVGRNLYWTDYALETIEVSKIDGSHR 1543
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3634-3666 2.46e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 58.03  E-value: 2.46e-10
                            10        20        30
                    ....*....|....*....|....*....|...
gi 126012573   3634 TCRPGQFRCANGRCIPQAWKCDVDNDCGDHSDE 3666
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 3358-3399 2.55e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 58.38  E-value: 2.55e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 126012573   3358 VIISTKLEWPNGITIDYTNDLLYWADAHLGYIEYSDLEGHHR 3399
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1271-1305 2.84e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 57.99  E-value: 2.84e-10
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 126012573 1271 CPSSYFHCDNGNCIHRAWLCDRDNDCGDMSDEKDC 1305
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1109-1143 3.05e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 57.99  E-value: 3.05e-10
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 126012573 1109 CLDTQYTCDNHQCISKNWVCDTDNDCGDGSDEKNC 1143
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1149-1183 3.26e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 57.60  E-value: 3.26e-10
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 126012573 1149 CQPSQFNCPNHRCIDLSFVCDGDKDCVDGSDEVGC 1183
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 183-217 3.78e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 57.60  E-value: 3.78e-10
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 126012573  183 CLHNEFSCGNGECIPRAYVCDHDNDCQDGSDEHAC 217
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3635-3666 5.06e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 57.22  E-value: 5.06e-10
                          10        20        30
                  ....*....|....*....|....*....|..
gi 126012573 3635 CRPGQFRCANGRCIPQAWKCDVDNDCGDHSDE 3666
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 503-548 5.21e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 57.23  E-value: 5.21e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 126012573    503 TLITENLGHPRGIAVDPTVGYLFFSDWeslsGEPKLERAFMDGSNR 548
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDW----GLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 864-904 5.47e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 57.23  E-value: 5.47e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 126012573    864 VINTTLGWPNGLAIDWAASRLYWVDAYFDKIEHSTFDGLDR 904
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2906-2938 5.58e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 57.22  E-value: 5.58e-10
                          10        20        30
                  ....*....|....*....|....*....|...
gi 126012573 2906 CLADEFKCDGGRCIPSEWICDGDNDCGDMSDED 2938
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1545-1589 6.15e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 57.23  E-value: 6.15e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 126012573   1545 VLISKNLTNPRGLALDPRmnEHLLFWSDWGhHPRIERASMDGSMR 1589
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWI--EGRLYWTDWG-LDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 4141-4176 8.01e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 56.84  E-value: 8.01e-10
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 126012573   4141 VMQPDGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYR 4176
Cdd:smart00135    8 LGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2993-3027 8.25e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 56.45  E-value: 8.25e-10
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 126012573 2993 CSENEFTCGYGLCIPKIFRCDRHNDCGDYSDERGC 3027
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3718-3751 9.58e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 56.49  E-value: 9.58e-10
                            10        20        30
                    ....*....|....*....|....*....|....
gi 126012573   3718 TCHPvGDFRCKNHHCIPLRWQCDGQNDCGDNSDE 3751
Cdd:smart00192    1 TCPP-GEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3758-3790 1.09e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 56.10  E-value: 1.09e-09
                            10        20        30
                    ....*....|....*....|....*....|...
gi 126012573   3758 ECTESEFRCVNQQCIPSRWICDHYNDCGDNSDE 3790
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 4197-4238 1.42e-09

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 56.01  E-value: 1.42e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 126012573  4197 GLMFWTDWGKEPKIESAWMNGEDRNILVFEDLGWPTGLSIDY 4238
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1067-1101 1.64e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 55.68  E-value: 1.64e-09
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 126012573 1067 CSSSAFTCGHGECIPAHWRCDKRNDCVDGSDEHNC 1101
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
2904-2937 1.84e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 55.72  E-value: 1.84e-09
                           10        20        30
                   ....*....|....*....|....*....|....
gi 126012573  2904 RTCLADEFKCDGGRCIPSEWICDGDNDCGDMSDE 2937
Cdd:pfam00057    1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3031-3063 2.29e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 55.33  E-value: 2.29e-09
                            10        20        30
                    ....*....|....*....|....*....|...
gi 126012573   3031 TCQQNQFTCQNGRCISKTFVCDEDNDCGDGSDE 3063
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1269-1305 2.33e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 55.33  E-value: 2.33e-09
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 126012573  1269 KTCPSSYFHCDNGNCIHRAWLCDRDNDCGDMSDEKDC 1305
Cdd:pfam00057    1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3032-3064 2.57e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 55.29  E-value: 2.57e-09
                          10        20        30
                  ....*....|....*....|....*....|...
gi 126012573 3032 CQQNQFTCQNGRCISKTFVCDEDNDCGDGSDEL 3064
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1270-1302 2.65e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 54.95  E-value: 2.65e-09
                            10        20        30
                    ....*....|....*....|....*....|...
gi 126012573   1270 TCPSSYFHCDNGNCIHRAWLCDRDNDCGDMSDE 1302
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 3333-3374 2.87e-09

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 55.24  E-value: 2.87e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 126012573  3333 GYLYWADWGHRAYIGRVGMDGTNKSVIISTKLEWPNGITIDY 3374
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3075-3109 2.91e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 54.91  E-value: 2.91e-09
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 126012573 3075 CPPHEFKCDNGRCIEMMKLCNHLDDCLDNSDEKGC 3109
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 222-256 3.06e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 54.91  E-value: 3.06e-09
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 126012573  222 CGGYQFTCPSGRCIYQNWVCDGEDDCKDNGDEDGC 256
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 4222-4264 3.12e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 55.30  E-value: 3.12e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 126012573   4222 ILVFEDLGWPTGLSIDYLNnDRIYWSDFKEDVIETIKYDGTDR 4264
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIE-GRLYWTDWGLDVIEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1148-1180 3.59e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 54.56  E-value: 3.59e-09
                            10        20        30
                    ....*....|....*....|....*....|...
gi 126012573   1148 TCQPSQFNCPNHRCIDLSFVCDGDKDCVDGSDE 1180
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2741-2775 3.61e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 54.91  E-value: 3.61e-09
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 126012573 2741 CSPTAFTCANGRCVQYSYRCDYYNDCGDGSDEAGC 2775
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 28-62 3.68e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 54.91  E-value: 3.68e-09
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 126012573   28 CDSAHFRCGSGHCIPADWRCDGTKDCSDDADEIGC 62
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2700-2732 4.18e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 54.52  E-value: 4.18e-09
                          10        20        30
                  ....*....|....*....|....*....|...
gi 126012573 2700 CGASSFTCSNGRCISEEWKCDNDNDCGDGSDEM 2732
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2699-2731 4.19e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 54.56  E-value: 4.19e-09
                            10        20        30
                    ....*....|....*....|....*....|...
gi 126012573   2699 RCGASSFTCSNGRCISEEWKCDNDNDCGDGSDE 2731
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3928-3962 6.50e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 54.13  E-value: 6.50e-09
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 126012573 3928 CTEYEYKCGNGHCIPHDNVCDDADDCGDWSDELGC 3962
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1148-1183 6.90e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 54.18  E-value: 6.90e-09
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 126012573  1148 TCQPSQFNCPNHRCIDLSFVCDGDKDCVDGSDEVGC 1183
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 108-142 7.90e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 53.75  E-value: 7.90e-09
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 126012573  108 CSSHQITCSNGQCIPSEYRCDHVRDCPDGADENDC 142
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3594-3626 8.55e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 53.75  E-value: 8.55e-09
                          10        20        30
                  ....*....|....*....|....*....|...
gi 126012573 3594 CDSNEWQCANKRCIPESWQCDTFNDCEDNSDED 3626
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
183-217 8.99e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 53.79  E-value: 8.99e-09
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 126012573   183 CLHNEFSCGNGECIPRAYVCDHDNDCQDGSDEHAC 217
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1066-1101 9.72e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 53.79  E-value: 9.72e-09
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 126012573  1066 TCSSSAFTCGHGECIPAHWRCDKRNDCVDGSDEHNC 1101
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3594-3625 9.91e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 53.41  E-value: 9.91e-09
                            10        20        30
                    ....*....|....*....|....*....|..
gi 126012573   3594 CDSNEWQCANKRCIPESWQCDTFNDCEDNSDE 3625
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 183-214 1.24e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 53.41  E-value: 1.24e-08
                            10        20        30
                    ....*....|....*....|....*....|..
gi 126012573    183 CLHNEFSCGNGECIPRAYVCDHDNDCQDGSDE 214
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1066-1098 1.25e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 53.02  E-value: 1.25e-08
                            10        20        30
                    ....*....|....*....|....*....|...
gi 126012573   1066 TCSSSAFTCGHGECIPAHWRCDKRNDCVDGSDE 1098
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
2863-2895 1.34e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 53.41  E-value: 1.34e-08
                           10        20        30
                   ....*....|....*....|....*....|...
gi 126012573  2863 TCSSSEFQCASGRCIPQHWYCDQETDCFDASDE 2895
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 2545-2585 1.41e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 53.37  E-value: 1.41e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 126012573   2545 IVNSSLVMPSGLTLDYEEDLLYWVDASLQRIERSTLTGVDR 2585
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1026-1060 1.46e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 52.98  E-value: 1.46e-08
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 126012573 1026 CGLFSFPCKNGRCVPNYYLCDGVDDCHDNSDEQLC 1060
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2863-2895 1.50e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 53.02  E-value: 1.50e-08
                            10        20        30
                    ....*....|....*....|....*....|...
gi 126012573   2863 TCSSSEFQCASGRCIPQHWYCDQETDCFDASDE 2895
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3717-3754 1.71e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 53.02  E-value: 1.71e-08
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 126012573  3717 RTCHPvGDFRCKNHHCIPLRWQCDGQNDCGDNSDEENC 3754
Cdd:pfam00057    1 STCSP-NEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 221-253 1.82e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 52.64  E-value: 1.82e-08
                            10        20        30
                    ....*....|....*....|....*....|...
gi 126012573    221 TCGGYQFTCPSGRCIYQNWVCDGEDDCKDNGDE 253
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2992-3024 1.93e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 52.64  E-value: 1.93e-08
                            10        20        30
                    ....*....|....*....|....*....|...
gi 126012573   2992 TCSENEFTCGYGLCIPKIFRCDRHNDCGDYSDE 3024
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3074-3106 2.21e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 52.64  E-value: 2.21e-08
                            10        20        30
                    ....*....|....*....|....*....|...
gi 126012573   3074 TCPPHEFKCDNGRCIEMMKLCNHLDDCLDNSDE 3106
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3633-3666 2.25e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 52.64  E-value: 2.25e-08
                           10        20        30
                   ....*....|....*....|....*....|....
gi 126012573  3633 RTCRPGQFRCANGRCIPQAWKCDVDNDCGDHSDE 3666
Cdd:pfam00057    1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3512-3544 2.49e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 52.25  E-value: 2.49e-08
                            10        20        30
                    ....*....|....*....|....*....|...
gi 126012573   3512 CSSTQFLCANNeKCIPIWWKCDGQKDCSDGSDE 3544
Cdd:smart00192    2 CPPGEFQCDNG-RCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 551-591 2.66e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 52.60  E-value: 2.66e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 126012573    551 LVKTKLGWPAGVTLDMISKRVYWVDSRFDYIETVTYDGIQR 591
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3512-3545 3.33e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 52.21  E-value: 3.33e-08
                          10        20        30
                  ....*....|....*....|....*....|....
gi 126012573 3512 CSSTQFLCANNeKCIPIWWKCDGQKDCSDGSDEL 3545
Cdd:cd00112     1 CPPNEFRCANG-RCIPSSWVCDGEDDCGDGSDEE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1109-1140 3.43e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 51.87  E-value: 3.43e-08
                            10        20        30
                    ....*....|....*....|....*....|..
gi 126012573   1109 CLDTQYTCDNHQCISKNWVCDTDNDCGDGSDE 1140
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2740-2772 3.90e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 51.87  E-value: 3.90e-08
                            10        20        30
                    ....*....|....*....|....*....|...
gi 126012573   2740 TCSPTAFTCANGRCVQYSYRCDYYNDCGDGSDE 2772
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1025-1057 4.26e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 51.87  E-value: 4.26e-08
                            10        20        30
                    ....*....|....*....|....*....|...
gi 126012573   1025 QCGLFSFPCKNGRCVPNYYLCDGVDDCHDNSDE 1057
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3031-3064 4.89e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 51.48  E-value: 4.89e-08
                           10        20        30
                   ....*....|....*....|....*....|....
gi 126012573  3031 TCQQNQFTCQNGRCISKTFVCDEDNDCGDGSDEL 3064
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEE 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 27-59 5.33e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 51.48  E-value: 5.33e-08
                            10        20        30
                    ....*....|....*....|....*....|...
gi 126012573     27 ECDSAHFRCGSGHCIPADWRCDGTKDCSDDADE 59
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 3262-3304 6.30e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 51.45  E-value: 6.30e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 126012573   3262 ETIINHRLPAAESLAVDWVSRKLYWLDARLDGLFVSDLNGGHR 3304
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3798-3832 6.48e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 51.05  E-value: 6.48e-08
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 126012573 3798 CHPEYFQCTSGHCVHSELKCDGSADCLDASDEADC 3832
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 776-818 7.37e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 51.45  E-value: 7.37e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 126012573    776 EILAANRVENVESLAFDWISKNLYWTDSHYKSISVMRLADKTR 818
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 107-139 7.89e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 51.09  E-value: 7.89e-08
                            10        20        30
                    ....*....|....*....|....*....|...
gi 126012573    107 TCSSHQITCSNGQCIPSEYRCDHVRDCPDGADE 139
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
2740-2775 8.62e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 51.10  E-value: 8.62e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 126012573  2740 TCSPTAFTCANGRCVQYSYRCDYYNDCGDGSDEAGC 2775
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1883-1928 8.67e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 51.01  E-value: 8.67e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 126012573  1883 GKLYWsdqgTDSGVPAKIASANMDGTSVKTLFTGNLEHLECVTLDI 1928
Cdd:pfam00058    1 GRLYW----TDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
2991-3027 1.05e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 50.71  E-value: 1.05e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 126012573  2991 RTCSENEFTCGYGLCIPKIFRCDRHNDCGDYSDERGC 3027
Cdd:pfam00057    1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 3321-3355 1.27e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 50.68  E-value: 1.27e-07
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 126012573   3321 DNPRGLALHPQYGYLYWADWGhRAYIGRVGMDGTN 3355
Cdd:smart00135    9 GHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTN 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 2227-2267 1.30e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 50.68  E-value: 1.30e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 126012573   2227 VLVSEGIVTPRGLAVDRSDGYVYWVDDSLDIIARIRINGEN 2267
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
2091-2252 1.38e-07

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 55.86  E-value: 1.38e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012573 2091 AGQGRNALHVDVDVSSGFIYWCDfsssvASDNAIRRIKPDGSSLMNIVTHGigeNGVRGIAVDWVAGNLYFTNAFVSEtl 2170
Cdd:COG3391    64 AAAVADADGADAGADGRRLYVAN-----SGSGRVSVIDLATGKVVATIPVG---GGPRGLAVDPDGGRLYVADSGNGR-- 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012573 2171 ieVLRINTTYRRVLLKVTV-DMPRHIVVDPKNRYLFWADYGQrPKIER--SFLDCTNRTVL--VSEGiVTPRGLAVDRSD 2245
Cdd:COG3391   134 --VSVIDTATGKVVATIPVgAGPHGIAVDPDGKRLYVANSGS-NTVSVivSVIDTATGKVVatIPVG-GGPVGVAVSPDG 209


                  ....*..
gi 126012573 2246 GYVYWVD 2252
Cdd:COG3391   210 RRLYVAN 216
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1521-1561 1.47e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 50.24  E-value: 1.47e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 126012573  1521 RNLYWTDYALE-TIEVSKIDGSHRTVLISKNLTNPRGLALDP 1561
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 838-879 1.51e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 50.24  E-value: 1.51e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 126012573   838 GYLFFTDWFRPAKIMRAWSDGSHLLPVINTTLGWPNGLAIDW 879
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 4177-4220 1.52e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 50.29  E-value: 1.52e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 126012573   4177 KWLISTDLDQPAAIAVNPKLGLMFWTDWGkEPKIESAWMNGEDR 4220
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTNR 43
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3074-3109 1.61e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 50.32  E-value: 1.61e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 126012573  3074 TCPPHEFKCDNGRCIEMMKLCNHLDDCLDNSDEKGC 3109
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1567-1607 1.62e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 50.24  E-value: 1.62e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 126012573  1567 LLFWSDWGHHPRIERASMDGSMRTVIVQDKIFWPCGLTIDY 1607
Cdd:pfam00058    2 RLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2864-2895 1.63e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 50.28  E-value: 1.63e-07
                          10        20        30
                  ....*....|....*....|....*....|..
gi 126012573 2864 CSSSEFQCASGRCIPQHWYCDQETDCFDASDE 2895
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 2182-2225 1.74e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 50.29  E-value: 1.74e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 126012573   2182 RVLLKVTVDMPRHIVVDPKNRYLFWADYGqRPKIERSFLDCTNR 2225
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTNR 43
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 2091-2300 1.92e-07

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 55.79  E-value: 1.92e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012573 2091 AGQGRNALHVDVDvSSGFIYWCDfsssvASDNAIRRIKPDGSSLMNIVTHGIGE---NGVRGIAVDwVAGNLYftnafVS 2167
Cdd:cd05819    51 DGQFNEPAGVAVD-SDGNLYVAD-----TGNHRIQKFDPDGNFLASFGGSGDGDgefNGPRGIAVD-SSGNIY-----VA 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012573 2168 ETL---IEVLRINTTYRRVLLKVTVDM-----PRHIVVDPKNrYLFWADYGQRpKIERSFLDCTNRTVLVSEGIV----- 2234
Cdd:cd05819   119 DTGnhrIQKFDPDGEFLTTFGSGGSGPgqfngPTGVAVDSDG-NIYVADTGNH-RIQVFDPDGNFLTTFGSTGTGpgqfn 196

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 126012573 2235 TPRGLAVDrSDGYVYwVDDSLDiiARIRI-NGENSEVIRYGSRYPT------PYGITVF-ENSIIWVDRNLKKI 2300
Cdd:cd05819   197 YPTGIAVD-SDGNIY-VADSGN--NRVQVfDPDGAGFGGNGNFLGSdgqfnrPSGLAVDsDGNLYVADTGNNRI 266
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
2699-2731 1.98e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 49.94  E-value: 1.98e-07
                           10        20        30
                   ....*....|....*....|....*....|...
gi 126012573  2699 RCGASSFTCSNGRCISEEWKCDNDNDCGDGSDE 2731
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
221-256 2.41e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 49.55  E-value: 2.41e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 126012573   221 TCGGYQFTCPSGRCIYQNWVCDGEDDCKDNGDEDGC 256
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1187-1222 3.23e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 49.13  E-value: 3.23e-07
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 126012573 1187 CTASQFKCASGdKCIGVTNRCDGVFDCSDNSDEAGC 1222
Cdd:cd00112     1 CPPNEFRCANG-RCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3797-3829 3.39e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 49.17  E-value: 3.39e-07
                            10        20        30
                    ....*....|....*....|....*....|...
gi 126012573   3797 TCHPEYFQCTSGHCVHSELKCDGSADCLDASDE 3829
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
28-62 3.64e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 49.17  E-value: 3.64e-07
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 126012573    28 CDSAHFRCGSGHCIPADWRCDGTKDCSDDADEIGC 62
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3928-3959 3.78e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 49.17  E-value: 3.78e-07
                            10        20        30
                    ....*....|....*....|....*....|..
gi 126012573   3928 CTEYEYKCGNGHCIPHDNVCDDADDCGDWSDE 3959
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2948-2988 4.33e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 48.74  E-value: 4.33e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 126012573 2948 CSDSEFLCVNdrppdRRCIPQSWVCDGDVDCTDGYDEnQNC 2988
Cdd:cd00112     1 CPPNEFRCAN-----GRCIPSSWVCDGEDDCGDGSDE-ENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 2459-2500 5.38e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 48.75  E-value: 5.38e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 126012573   2459 TVIASGIGTADGIAFDWITRRIYYSDYLNQMINSMAEDGSNR 2500
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 3219-3260 6.36e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 48.75  E-value: 6.36e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 126012573   3219 YSLILEGLDNVVALDFDRVEKRLYWIDTQRQVIERMFLNKTN 3260
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1230-1264 7.00e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 48.36  E-value: 7.00e-07
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 126012573 1230 CHSDEFQCQeDGICIPNFWECDGHPDCLYGSDEHN 1264
Cdd:cd00112     1 CPPNEFRCA-NGRCIPSSWVCDGEDDCGDGSDEEN 34
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3796-3832 7.73e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 48.40  E-value: 7.73e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 126012573  3796 RTCHPEYFQCTSGHCVHSELKCDGSADCLDASDEADC 3832
Cdd:pfam00057    1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3682-3714 9.11e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 47.97  E-value: 9.11e-07
                          10        20        30
                  ....*....|....*....|....*....|...
gi 126012573 3682 TEFSCKtNYRCIPKWAVCNGVDDCRDNSDEQGC 3714
Cdd:cd00112     4 NEFRCA-NGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1591-1632 1.01e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 47.98  E-value: 1.01e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 126012573   1591 VIVQDKIFWPCGLTIDYPNRLLYFMDSYLDYMDFCDYNGHHR 1632
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3885-3915 1.36e-06

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 47.63  E-value: 1.36e-06
                            10        20        30
                    ....*....|....*....|....*....|.
gi 126012573   3885 SPNRFRCDNNRCIYSHEVCNGVDDCGDGTDE 3915
Cdd:smart00192    3 PPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2948-2984 1.38e-06

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 47.24  E-value: 1.38e-06
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 126012573   2948 CSDSEFLCVNdrppdRRCIPQSWVCDGDVDCTDGYDE 2984
Cdd:smart00192    2 CPPGEFQCDN-----GRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1230-1262 1.43e-06

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 47.24  E-value: 1.43e-06
                            10        20        30
                    ....*....|....*....|....*....|...
gi 126012573   1230 CHSDEFQCQeDGICIPNFWECDGHPDCLYGSDE 1262
Cdd:smart00192    2 CPPGEFQCD-NGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1109-1143 1.43e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 47.63  E-value: 1.43e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 126012573  1109 CLDTQYTCDNHQCISKNWVCDTDNDCGDGSDEKNC 1143
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
106-142 1.46e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 47.63  E-value: 1.46e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 126012573   106 STCSSHQITCSNGQCIPSEYRCDHVRDCPDGADENDC 142
Cdd:pfam00057    1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3885-3915 1.50e-06

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 47.20  E-value: 1.50e-06
                          10        20        30
                  ....*....|....*....|....*....|.
gi 126012573 3885 SPNRFRCDNNRCIYSHEVCNGVDDCGDGTDE 3915
Cdd:cd00112     2 PPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 3282-3330 1.58e-06

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 47.54  E-value: 1.58e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 126012573  3282 RKLYWLDARLD-GLFVSDLNGGHRRMLAQHcvdanntfCFDNPRGLALHP 3330
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTD--------DLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 2500-2542 1.66e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 47.60  E-value: 1.66e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 126012573   2500 RTVIAR-VPKPRAIVLDPCQGYLYWADWDTHaKIERATLGGNFR 2542
Cdd:smart00135    1 RTLLSSgLGHPNGLAVDWIEGRLYWTDWGLD-VIEVANLDGTNR 43
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3759-3793 1.80e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 47.24  E-value: 1.80e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 126012573  3759 CTESEFRCVNQQCIPSRWICDHYNDCGDNSDERDC 3793
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1911-1953 1.96e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 47.21  E-value: 1.96e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 126012573   1911 KTLFTGNLEHLECVTLDIEEQKLYWAVTGRGVIERGNVDGTDR 1953
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1869-1910 2.08e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 47.21  E-value: 2.08e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 126012573   1869 GVGFPIGITVDPARGKLYWSDQGTDsgvpaKIASANMDGTSV 1910
Cdd:smart00135    7 GLGHPNGLAVDWIEGRLYWTDWGLD-----VIEVANLDGTNR 43
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1353-1388 3.24e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 46.47  E-value: 3.24e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 126012573  1353 CSDFNGGCTHECVQEPFGAKCLCPLGFLLANDSKTC 1388
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 2519-2560 3.26e-06

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 46.77  E-value: 3.26e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 126012573  2519 GYLYWADWDTHAKIERATLGGNFRVPIVNSSLVMPSGLTLDY 2560
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3594-3625 3.86e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 46.09  E-value: 3.86e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 126012573  3594 CDSNEWQCANKRCIPESWQCDTFNDCEDNSDE 3625
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3926-3962 4.01e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 46.09  E-value: 4.01e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 126012573  3926 KPCTEYEYKCGNGHCIPHDNVCDDADDCGDWSDELGC 3962
Cdd:pfam00057    1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 2022-2058 4.06e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 46.08  E-value: 4.06e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 126012573  2022 CSNNMNACQQICLPVPGGlFSCACATGFKLNPDNRSC 2058
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGG-YTCSCPEGYELQDDGRTC 36
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2784-2817 4.37e-06

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 46.05  E-value: 4.37e-06
                          10        20        30
                  ....*....|....*....|....*....|....
gi 126012573 2784 TEFMCNNRRCIPREFICNGVDNCHDNntSDEKNC 2817
Cdd:cd00112     4 NEFRCANGRCIPSSWVCDGEDDCGDG--SDEENC 35
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
394-579 4.88e-06

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 51.23  E-value: 4.88e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012573  394 ASIIFSNGRDLLIGDIHGRSFRILVESQNRGVAVGVAFHYHL--QRVFWTDTVQNKVFSVDINGLNIQEVLNVSVEtPEN 471
Cdd:COG3391    36 LLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGAdgRRLYVANSGSGRVSVIDLATGKVVATIPVGGG-PRG 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012573  472 LAVDWVNNKIYLVETKVNRIDMVNL-DGSYRVTLITENlgHPRGIAVDPTVGYLFFSDWeslsGEPKLER--AFMDGSNR 548
Cdd:COG3391   115 LAVDPDGGRLYVADSGNGRVSVIDTaTGKVVATIPVGA--GPHGIAVDPDGKRLYVANS----GSNTVSVivSVIDTATG 188

                         170       180       190
                  ....*....|....*....|....*....|..
gi 126012573  549 KDLVKTKLG-WPAGVTLDMISKRVYWVDSRFD 579
Cdd:COG3391   189 KVVATIPVGgGPVGVAVSPDGRRLYVANRGSN 220
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
2392-2630 6.09e-06

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 51.17  E-value: 6.09e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012573 2392 FALSNSLRSLHLDPENHSppFQTINVER----TVMSLDYDsvsDRIYFTQNLASGVGQISYATlssgiHTPTVIASGIGT 2467
Cdd:COG4257    32 FTDQGGGRIGRLDPATGE--FTEYPLGGgsgpHGIAVDPD---GNLWFTDNGNNRIGRIDPKT-----GEITTFALPGGG 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012573 2468 AD--GIAFD-----WITrriyysdylNQMINSMAE-DGSNRTVIA-RVPK----PRAIVLDPcQGYLYWADWDTHA--KI 2532
Cdd:COG4257   102 SNphGIAFDpdgnlWFT---------DQGGNRIGRlDPATGEVTEfPLPTggagPYGIAVDP-DGNLWVTDFGANAigRI 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012573 2533 ERATlgGNFRVPIVNSSLVMPSGLTLDyEEDLLYWVDA---SLQRIerSTLTGVDREVIV-NAAVHAFGLTLYGQ-YIYW 2607
Cdd:COG4257   172 DPDT--GTLTEYALPTPGAGPRGLAVD-PDGNLWVADTgsgRIGRF--DPKTGTVTEYPLpGGGARPYGVAVDGDgRVWF 246

                         250       260
                  ....*....|....*....|...
gi 126012573 2608 TDLYTQRIYRankYDGSGQIAMT 2630
Cdd:COG4257   247 AESGANRIVR---FDPDTELTEY 266
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2821-2854 6.11e-06

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 45.70  E-value: 6.11e-06
                            10        20        30
                    ....*....|....*....|....*....|....
gi 126012573   2821 TCQSGYTKCHNSNiCIPRVYLCDGDNDCGDNSDE 2854
Cdd:smart00192    1 TCPPGEFQCDNGR-CIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 4154-4194 6.86e-06

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 45.61  E-value: 6.86e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 126012573  4154 RHIYWSDVKNK-RIEVAKLDGRYRKWLISTDLDQPAAIAVNP 4194
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 3121-3150 7.04e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 45.31  E-value: 7.04e-06
                           10        20        30
                   ....*....|....*....|....*....|
gi 126012573  3121 GCDHNCTDTLTSFYCSCRPGYKLMSDKRTC 3150
Cdd:pfam14670    7 GCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1025-1060 8.97e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 45.32  E-value: 8.97e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 126012573  1025 QCGLFSFPCKNGRCVPNYYLCDGVDDCHDNSDEQLC 1060
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
2236-2544 9.15e-06

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 50.79  E-value: 9.15e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012573 2236 PRGLAVDRsDGYVYWVDDSLDIIARIRINGENSEVIRYGSRyPTPYGITVFENSIIWV-DRNLKKIFQaskepenteppt 2314
Cdd:COG4257    19 PRDVAVDP-DGAVWFTDQGGGRIGRLDPATGEFTEYPLGGG-SGPHGIAVDPDGNLWFtDNGNNRIGR------------ 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012573 2315 virdninwlrdVTIFDKQVQprspaevnnnpclennggcshlCFALPGLHTPKCDCAFGtlqSDGKncaistenfLIFAL 2394
Cdd:COG4257    85 -----------IDPKTGEIT----------------------TFALPGGGSNPHGIAFD---PDGN---------LWFTD 119

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012573 2395 SNSLRSLHLDPENHSppFQTINVERTV---MSLDYDSvSDRIYFTQNLASGVGQISYATLSSGIHT-PTVIA--SGIG-T 2467
Cdd:COG4257   120 QGGNRIGRLDPATGE--VTEFPLPTGGagpYGIAVDP-DGNLWVTDFGANAIGRIDPDTGTLTEYAlPTPGAgpRGLAvD 196

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012573 2468 ADGiafdwitrRIYYSDYLN---QMINsmAEDGSNRTVI--ARVPKPRAIVLDPcQGYLYWADWDTH--AKIERATLGGN 2540
Cdd:COG4257   197 PDG--------NLWVADTGSgriGRFD--PKTGTVTEYPlpGGGARPYGVAVDG-DGRVWFAESGANriVRFDPDTELTE 265


                  ....
gi 126012573 2541 FRVP 2544
Cdd:COG4257   266 YVLP 269
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 461-501 1.07e-05

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 45.29  E-value: 1.07e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 126012573    461 VLNVSVETPENLAVDWVNNKIYLVETKVNRIDMVNLDGSYR 501
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
EGF_CA smart00179
Calcium-binding EGF-like domain;
4007-4047 1.27e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.93  E-value: 1.27e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 126012573   4007 DINECEQFGTCPQH--CRNTKGSYECVCADGFTSmsdrpGKRC 4047
Cdd:smart00179    1 DIDECASGNPCQNGgtCVNTVGSYRCECPPGYTD-----GRNC 38
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1187-1219 1.45e-05

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 44.55  E-value: 1.45e-05
                            10        20        30
                    ....*....|....*....|....*....|...
gi 126012573   1187 CTASQFKCASGdKCIGVTNRCDGVFDCSDNSDE 1219
Cdd:smart00192    2 CPPGEFQCDNG-RCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3682-3711 1.63e-05

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 44.55  E-value: 1.63e-05
                            10        20        30
                    ....*....|....*....|....*....|
gi 126012573   3682 TEFSCKtNYRCIPKWAVCNGVDDCRDNSDE 3711
Cdd:smart00192    5 GEFQCD-NGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1230-1264 1.65e-05

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 44.55  E-value: 1.65e-05
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 126012573  1230 CHSDEFQCQeDGICIPNFWECDGHPDCLYGSDEHN 1264
Cdd:pfam00057    3 CSPNEFQCG-SGECIPRSWVCDGDPDCGDGSDEEN 36
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 2346-2382 1.86e-05

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 44.16  E-value: 1.86e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 126012573  2346 CLENNGGCSHLCFALPGLHTpkCDCAFG-TLQSDGKNC 2382
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYT--CSCPEGyELQDDGRTC 36
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 490-519 2.02e-05

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 44.46  E-value: 2.02e-05
                           10        20        30
                   ....*....|....*....|....*....|
gi 126012573   490 RIDMVNLDGSYRVTLITENLGHPRGIAVDP 519
Cdd:pfam00058   13 SISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 3147-3190 2.09e-05

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 48.92  E-value: 2.09e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 126012573 3147 KRTCVDIDECTEMPFVCSQKCENVIGSYICKCAPGYLREPDGKT 3190
Cdd:cd01475   181 GKICVVPDLCATLSHVCQQVCISTPGSYLCACTEGYALLEDNKT 224
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2784-2814 2.34e-05

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 43.78  E-value: 2.34e-05
                            10        20        30
                    ....*....|....*....|....*....|.
gi 126012573   2784 TEFMCNNRRCIPREFICNGVDNCHDNntSDE 2814
Cdd:smart00192    5 GEFQCDNGRCIPSSWVCDGVDDCGDG--SDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
2948-2988 3.21e-05

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 43.78  E-value: 3.21e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 126012573  2948 CSDSEFLCvndrpPDRRCIPQSWVCDGDVDCTDGYDEnQNC 2988
Cdd:pfam00057    3 CSPNEFQC-----GSGECIPRSWVCDGDPDCGDGSDE-ENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2822-2855 3.23e-05

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 43.73  E-value: 3.23e-05
                          10        20        30
                  ....*....|....*....|....*....|....
gi 126012573 2822 CQSGYTKCHNSNiCIPRVYLCDGDNDCGDNSDEN 2855
Cdd:cd00112     1 CPPNEFRCANGR-CIPSSWVCDGEDDCGDGSDEE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3512-3545 3.51e-05

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 43.39  E-value: 3.51e-05
                           10        20        30
                   ....*....|....*....|....*....|....
gi 126012573  3512 CSSTQFLCANNEkCIPIWWKCDGQKDCSDGSDEL 3545
Cdd:pfam00057    3 CSPNEFQCGSGE-CIPRSWVCDGDPDCGDGSDEE 35
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 2202-2242 4.79e-05

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 43.30  E-value: 4.79e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 126012573  2202 RYLFWADYGQRPKIERSFLDCTNRTVLVSEGIVTPRGLAVD 2242
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
EGF_CA smart00179
Calcium-binding EGF-like domain;
1390-1429 5.13e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.00  E-value: 5.13e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 126012573   1390 DIDECDILGSCSQH--CYNMRGSFRCSCDTGYmleSDGRTCK 1429
Cdd:smart00179    1 DIDECASGNPCQNGgtCVNTVGSYRCECPPGY---TDGRNCE 39
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
2820-2854 6.91e-05

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 42.62  E-value: 6.91e-05
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 126012573  2820 RTCQSGYTKCHnSNICIPRVYLCDGDNDCGDNSDE 2854
Cdd:pfam00057    1 STCSPNEFQCG-SGECIPRSWVCDGDPDCGDGSDE 34
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1398-1428 7.49e-05

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 42.61  E-value: 7.49e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 126012573  1398 GSCSQHCYNMRGSFRCSCDTGYMLESDGRTC 1428
Cdd:pfam14670    6 GGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 4007-4047 7.62e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.62  E-value: 7.62e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 126012573 4007 DINECEQFGTCPQH--CRNTKGSYECVCADGFTsmsdrpGKRC 4047
Cdd:cd00054     1 DIDECASGNPCQNGgtCVNTVGSYRCSCPPGYT------GRNC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 266-300 1.53e-04

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 41.81  E-value: 1.53e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 126012573  266 CSPREWSCPeSGRCISIYKVCDGILDCPGREDENN 300
Cdd:cd00112     1 CPPNEFRCA-NGRCIPSSWVCDGEDDCGDGSDEEN 34
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3553-3584 1.54e-04

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 41.46  E-value: 1.54e-04
                            10        20        30
                    ....*....|....*....|....*....|..
gi 126012573   3553 CRLGQFQCSDGNCTSPQTLCNAHQNCPDGSDE 3584
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 3377-3417 1.72e-04

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 41.76  E-value: 1.72e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 126012573  3377 DLLYWADAHLGY-IEYSDLEGHHRHTVYDGALPHPFAITIFE 3417
Cdd:pfam00058    1 GRLYWTDSSLRAsISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 149-179 1.77e-04

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 41.42  E-value: 1.77e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 126012573  149 QLTCDNGACYNTSQKCDWKVDCRDSSDEINC 179
Cdd:cd00112     5 EFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 429-519 1.91e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 46.52  E-value: 1.91e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012573  429 VAFHYHLQRVFWTDTVQNKVFSVDINGLNIQEVLNVSVET-----PENLAVDwVNNKIYLVETKVNRIDMVNLDGSYRVT 503
Cdd:cd14963   105 AGLAIDDGKLYVSDVKKHKVIVFDLEGKLLLEFGKPGSEPgelsyPNGIAVD-EDGNIYVADSGNGRIQVFDKNGKFIKE 183

                          90       100
                  ....*....|....*....|.
gi 126012573  504 L-----ITENLGHPRGIAVDP 519
Cdd:cd14963   184 LngspdGKSGFVNPRGIAVDP 204
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 3408-3441 2.30e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 41.43  E-value: 2.30e-04
                            10        20        30
                    ....*....|....*....|....*....|....
gi 126012573   3408 PHPFAITIFEDTIYWTDWNTRTVEKgNKYDGSNR 3441
Cdd:smart00135   11 PNGLAVDWIEGRLYWTDWGLDVIEV-ANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 818-860 2.61e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 41.43  E-value: 2.61e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 126012573    818 RRTVVQYLNNPRSVVVHPFAGYLFFTDWFRPaKIMRAWSDGSH 860
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLD-VIEVANLDGTN 42
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3885-3920 3.60e-04

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 40.69  E-value: 3.60e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 126012573  3885 SPNRFRCDNNRCIYSHEVCNGVDDCGDGTDetEEHC 3920
Cdd:pfam00057    4 SPNEFQCGSGECIPRSWVCDGDPDCGDGSD--EENC 37
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 3469-3498 4.26e-04

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 40.30  E-value: 4.26e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 126012573  3469 CGTNNGGCSHLCLIKPGgkGFTCECPDDFR 3498
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPG--GYTCSCPEGYE 28
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3553-3585 4.49e-04

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 40.27  E-value: 4.49e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 126012573 3553 CRLGQFQCSDGNCTSPQTLCNAHQNCPDGSDED 3585
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 265-298 4.76e-04

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 40.31  E-value: 4.76e-04
                            10        20        30
                    ....*....|....*....|....*....|....
gi 126012573    265 KCSPREWSCPeSGRCISIYKVCDGILDCPGREDE 298
Cdd:smart00192    1 TCPPGEFQCD-NGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
2785-2817 5.88e-04

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 39.92  E-value: 5.88e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 126012573  2785 EFMCNNRRCIPREFICNGVDNCHDNntSDEKNC 2817
Cdd:pfam00057    7 EFQCGSGECIPRSWVCDGDPDCGDG--SDEENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3683-3714 6.18e-04

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 39.92  E-value: 6.18e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 126012573  3683 EFSCKTNyRCIPKWAVCNGVDDCRDNSDEQGC 3714
Cdd:pfam00057    7 EFQCGSG-ECIPRSWVCDGDPDCGDGSDEENC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
3152-3191 8.03e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.92  E-value: 8.03e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 126012573   3152 DIDECTEMPfVCSQ--KCENVIGSYICKCAPGYLrepDGKTC 3191
Cdd:smart00179    1 DIDECASGN-PCQNggTCVNTVGSYRCECPPGYT---DGRNC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1390-1429 8.55e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.54  E-value: 8.55e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 126012573 1390 DIDECDILGSCSQH--CYNMRGSFRCSCDTGYMlesdGRTCK 1429
Cdd:cd00054     1 DIDECASGNPCQNGgtCVNTVGSYRCSCPPGYT----GRNCE 38
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1311-1344 9.20e-04

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 39.54  E-value: 9.20e-04
                            10        20        30
                    ....*....|....*....|....*....|....
gi 126012573   1311 RCPSWQWQClGHNICVNLSVVCDGIFDCPNGTDE 1344
Cdd:smart00192    1 TCPPGEFQC-DNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1187-1222 9.81e-04

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 39.54  E-value: 9.81e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 126012573  1187 CTASQFKCASGdKCIGVTNRCDGVFDCSDNSDEAGC 1222
Cdd:pfam00057    3 CSPNEFQCGSG-ECIPRSWVCDGDPDCGDGSDEENC 37
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 981-1013 1.00e-03

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 39.53  E-value: 1.00e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 126012573   981 NGDCSHFCFPVPNfQRVCGCPYGMRLASNHLTC 1013
Cdd:pfam14670    5 NGGCSHLCLNTPG-GYTCSCPEGYELQDDGRTC 36
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 1787-1951 1.18e-03

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 44.11  E-value: 1.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012573 1787 DAEQYIYWVENP-GEIHRVKTDGTNRTVFASISmvGPSMNLALD-----WI---SRNLYSTNPRTQSIEVLTLHGDIRYR 1857
Cdd:COG3386    16 DPDGRLYWVDIPgGRIHRYDPDGGAVEVFAEPS--GRPNGLAFDpdgrlLVadhGRGLVRFDPADGEVTVLADEYGKPLN 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012573 1858 ktlIANDGtalgvgfpigiTVDPArGKLYWSDQGTDSGvPAKIASANMDGtSVKTLFTG----N-LehleCVTLDieEQK 1932
Cdd:COG3386    94 ---RPNDG-----------VVDPD-GRLYFTDMGEYLP-TGALYRVDPDG-SLRVLADGltfpNgI----AFSPD--GRT 150

                         170
                  ....*....|....*....
gi 126012573 1933 LYWAVTGRGVIERGNVDGT 1951
Cdd:COG3386   151 LYVADTGAGRIYRFDLDAD 169
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 2470-2575 1.40e-03

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 43.85  E-value: 1.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012573 2470 GIAFDwITRRIYYSDYLNQMI-------NSMAEDGSNRTVIARVPKPRAIVLDPcQGYLYWADWDTHA----KIERATLG 2538
Cdd:cd05819   153 GVAVD-SDGNIYVADTGNHRIqvfdpdgNFLTTFGSTGTGPGQFNYPTGIAVDS-DGNIYVADSGNNRvqvfDPDGAGFG 230

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 126012573 2539 GNFRVPIVNSSLVMPSGLTLDyEEDLLYWVDASLQRI 2575
Cdd:cd05819   231 GNGNFLGSDGQFNRPSGLAVD-SDGNLYVADTGNNRI 266
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 2655-2692 1.40e-03

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 39.15  E-value: 1.40e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 126012573  2655 CEQFNGGCSHICAPGPNGAECQCPHEgnWYLANNRKHC 2692
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEG--YELQDDGRTC 36
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 663-704 1.96e-03

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 38.76  E-value: 1.96e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 126012573   663 CKDNNGGCEQVCVlshrtdNDGLGFRCKCTFGFQLDTDERHC 704
Cdd:pfam14670    1 CSVNNGGCSHLCL------NTPGGYTCSCPEGYELQDDGRTC 36
EGF_CA pfam07645
Calcium-binding EGF domain;
4007-4035 2.20e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 38.37  E-value: 2.20e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 126012573  4007 DINECEQFGT-CPQ--HCRNTKGSYECVCADG 4035
Cdd:pfam07645    1 DVDECATGTHnCPAntVCVNTIGSFECRCPDG 32
EGF_CA pfam07645
Calcium-binding EGF domain;
3152-3181 2.65e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.99  E-value: 2.65e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 126012573  3152 DIDECTEMPFVCSQ--KCENVIGSYICKCAPG 3181
Cdd:pfam07645    1 DVDECATGTHNCPAntVCVNTIGSFECRCPDG 32
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1461-1500 2.99e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 38.35  E-value: 2.99e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 126012573   1461 LVENGSYIVAVDFDSISGRIFWSDATQGKTWSAFQNGTDR 1500
Cdd:smart00135    4 LSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
EGF_CA smart00179
Calcium-binding EGF-like domain;
3111-3151 3.88e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 3.88e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 126012573   3111 INECHDPSISGCDHNCTDTLTSFYCSCRPGYklmSDKRTCV 3151
Cdd:smart00179    2 IDECASGNPCQNGGTCVNTVGSYRCECPPGY---TDGRNCE 39
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 2593-2625 5.90e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 37.58  E-value: 5.90e-03
                            10        20        30
                    ....*....|....*....|....*....|...
gi 126012573   2593 VHAFGLTLYGQYIYWTDLYTQRIYRANkYDGSG 2625
Cdd:smart00135   11 PNGLAVDWIEGRLYWTDWGLDVIEVAN-LDGTN 42
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 4338-4356 6.96e-03

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 37.22  E-value: 6.96e-03
                           10
                   ....*....|....*....
gi 126012573  4338 CSHLCLLRPGGYSCACPQG 4356
Cdd:pfam14670    8 CSHLCLNTPGGYTCSCPEG 26
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1811-1855 7.85e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 37.20  E-value: 7.85e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 126012573   1811 RTVFASisMVGPSMNLALDWISRNLYSTNPRTQSIEVLTLHGDIR 1855
Cdd:smart00135    1 RTLLSS--GLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 436-476 8.05e-03

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 37.14  E-value: 8.05e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 126012573   436 QRVFWTDTVQ-NKVFSVDINGLNIQEVLNVSVETPENLAVDW 476
Cdd:pfam00058    1 GRLYWTDSSLrASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
 
Name Accession Description Interval E-value
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3759-3793 3.35e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 60.68  E-value: 3.35e-11
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 126012573 3759 CTESEFRCVNQQCIPSRWICDHYNDCGDNSDERDC 3793
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3719-3754 9.52e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 59.14  E-value: 9.52e-11
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 126012573 3719 CHPvGDFRCKNHHCIPLRWQCDGQNDCGDNSDEENC 3754
Cdd:cd00112     1 CPP-NEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2905-2937 1.32e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 58.80  E-value: 1.32e-10
                            10        20        30
                    ....*....|....*....|....*....|...
gi 126012573   2905 TCLADEFKCDGGRCIPSEWICDGDNDCGDMSDE 2937
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1501-1543 1.55e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 58.77  E-value: 1.55e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 126012573   1501 RVVFDSSIILTETIAIDWVGRNLYWTDYALETIEVSKIDGSHR 1543
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3634-3666 2.46e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 58.03  E-value: 2.46e-10
                            10        20        30
                    ....*....|....*....|....*....|...
gi 126012573   3634 TCRPGQFRCANGRCIPQAWKCDVDNDCGDHSDE 3666
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 3358-3399 2.55e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 58.38  E-value: 2.55e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 126012573   3358 VIISTKLEWPNGITIDYTNDLLYWADAHLGYIEYSDLEGHHR 3399
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1271-1305 2.84e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 57.99  E-value: 2.84e-10
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 126012573 1271 CPSSYFHCDNGNCIHRAWLCDRDNDCGDMSDEKDC 1305
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1109-1143 3.05e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 57.99  E-value: 3.05e-10
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 126012573 1109 CLDTQYTCDNHQCISKNWVCDTDNDCGDGSDEKNC 1143
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1149-1183 3.26e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 57.60  E-value: 3.26e-10
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 126012573 1149 CQPSQFNCPNHRCIDLSFVCDGDKDCVDGSDEVGC 1183
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 183-217 3.78e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 57.60  E-value: 3.78e-10
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 126012573  183 CLHNEFSCGNGECIPRAYVCDHDNDCQDGSDEHAC 217
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3635-3666 5.06e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 57.22  E-value: 5.06e-10
                          10        20        30
                  ....*....|....*....|....*....|..
gi 126012573 3635 CRPGQFRCANGRCIPQAWKCDVDNDCGDHSDE 3666
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 503-548 5.21e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 57.23  E-value: 5.21e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 126012573    503 TLITENLGHPRGIAVDPTVGYLFFSDWeslsGEPKLERAFMDGSNR 548
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDW----GLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 864-904 5.47e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 57.23  E-value: 5.47e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 126012573    864 VINTTLGWPNGLAIDWAASRLYWVDAYFDKIEHSTFDGLDR 904
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2906-2938 5.58e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 57.22  E-value: 5.58e-10
                          10        20        30
                  ....*....|....*....|....*....|...
gi 126012573 2906 CLADEFKCDGGRCIPSEWICDGDNDCGDMSDED 2938
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1545-1589 6.15e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 57.23  E-value: 6.15e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 126012573   1545 VLISKNLTNPRGLALDPRmnEHLLFWSDWGhHPRIERASMDGSMR 1589
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWI--EGRLYWTDWG-LDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 4141-4176 8.01e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 56.84  E-value: 8.01e-10
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 126012573   4141 VMQPDGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYR 4176
Cdd:smart00135    8 LGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2993-3027 8.25e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 56.45  E-value: 8.25e-10
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 126012573 2993 CSENEFTCGYGLCIPKIFRCDRHNDCGDYSDERGC 3027
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3718-3751 9.58e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 56.49  E-value: 9.58e-10
                            10        20        30
                    ....*....|....*....|....*....|....
gi 126012573   3718 TCHPvGDFRCKNHHCIPLRWQCDGQNDCGDNSDE 3751
Cdd:smart00192    1 TCPP-GEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3758-3790 1.09e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 56.10  E-value: 1.09e-09
                            10        20        30
                    ....*....|....*....|....*....|...
gi 126012573   3758 ECTESEFRCVNQQCIPSRWICDHYNDCGDNSDE 3790
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 4197-4238 1.42e-09

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 56.01  E-value: 1.42e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 126012573  4197 GLMFWTDWGKEPKIESAWMNGEDRNILVFEDLGWPTGLSIDY 4238
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1067-1101 1.64e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 55.68  E-value: 1.64e-09
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 126012573 1067 CSSSAFTCGHGECIPAHWRCDKRNDCVDGSDEHNC 1101
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
2904-2937 1.84e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 55.72  E-value: 1.84e-09
                           10        20        30
                   ....*....|....*....|....*....|....
gi 126012573  2904 RTCLADEFKCDGGRCIPSEWICDGDNDCGDMSDE 2937
Cdd:pfam00057    1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3031-3063 2.29e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 55.33  E-value: 2.29e-09
                            10        20        30
                    ....*....|....*....|....*....|...
gi 126012573   3031 TCQQNQFTCQNGRCISKTFVCDEDNDCGDGSDE 3063
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1269-1305 2.33e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 55.33  E-value: 2.33e-09
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 126012573  1269 KTCPSSYFHCDNGNCIHRAWLCDRDNDCGDMSDEKDC 1305
Cdd:pfam00057    1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3032-3064 2.57e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 55.29  E-value: 2.57e-09
                          10        20        30
                  ....*....|....*....|....*....|...
gi 126012573 3032 CQQNQFTCQNGRCISKTFVCDEDNDCGDGSDEL 3064
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1270-1302 2.65e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 54.95  E-value: 2.65e-09
                            10        20        30
                    ....*....|....*....|....*....|...
gi 126012573   1270 TCPSSYFHCDNGNCIHRAWLCDRDNDCGDMSDE 1302
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 3333-3374 2.87e-09

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 55.24  E-value: 2.87e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 126012573  3333 GYLYWADWGHRAYIGRVGMDGTNKSVIISTKLEWPNGITIDY 3374
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3075-3109 2.91e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 54.91  E-value: 2.91e-09
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 126012573 3075 CPPHEFKCDNGRCIEMMKLCNHLDDCLDNSDEKGC 3109
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 222-256 3.06e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 54.91  E-value: 3.06e-09
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 126012573  222 CGGYQFTCPSGRCIYQNWVCDGEDDCKDNGDEDGC 256
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 4222-4264 3.12e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 55.30  E-value: 3.12e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 126012573   4222 ILVFEDLGWPTGLSIDYLNnDRIYWSDFKEDVIETIKYDGTDR 4264
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIE-GRLYWTDWGLDVIEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1148-1180 3.59e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 54.56  E-value: 3.59e-09
                            10        20        30
                    ....*....|....*....|....*....|...
gi 126012573   1148 TCQPSQFNCPNHRCIDLSFVCDGDKDCVDGSDE 1180
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2741-2775 3.61e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 54.91  E-value: 3.61e-09
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 126012573 2741 CSPTAFTCANGRCVQYSYRCDYYNDCGDGSDEAGC 2775
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 28-62 3.68e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 54.91  E-value: 3.68e-09
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 126012573   28 CDSAHFRCGSGHCIPADWRCDGTKDCSDDADEIGC 62
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2700-2732 4.18e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 54.52  E-value: 4.18e-09
                          10        20        30
                  ....*....|....*....|....*....|...
gi 126012573 2700 CGASSFTCSNGRCISEEWKCDNDNDCGDGSDEM 2732
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2699-2731 4.19e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 54.56  E-value: 4.19e-09
                            10        20        30
                    ....*....|....*....|....*....|...
gi 126012573   2699 RCGASSFTCSNGRCISEEWKCDNDNDCGDGSDE 2731
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3928-3962 6.50e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 54.13  E-value: 6.50e-09
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 126012573 3928 CTEYEYKCGNGHCIPHDNVCDDADDCGDWSDELGC 3962
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1148-1183 6.90e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 54.18  E-value: 6.90e-09
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 126012573  1148 TCQPSQFNCPNHRCIDLSFVCDGDKDCVDGSDEVGC 1183
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 108-142 7.90e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 53.75  E-value: 7.90e-09
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 126012573  108 CSSHQITCSNGQCIPSEYRCDHVRDCPDGADENDC 142
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3594-3626 8.55e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 53.75  E-value: 8.55e-09
                          10        20        30
                  ....*....|....*....|....*....|...
gi 126012573 3594 CDSNEWQCANKRCIPESWQCDTFNDCEDNSDED 3626
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
183-217 8.99e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 53.79  E-value: 8.99e-09
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 126012573   183 CLHNEFSCGNGECIPRAYVCDHDNDCQDGSDEHAC 217
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1066-1101 9.72e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 53.79  E-value: 9.72e-09
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 126012573  1066 TCSSSAFTCGHGECIPAHWRCDKRNDCVDGSDEHNC 1101
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3594-3625 9.91e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 53.41  E-value: 9.91e-09
                            10        20        30
                    ....*....|....*....|....*....|..
gi 126012573   3594 CDSNEWQCANKRCIPESWQCDTFNDCEDNSDE 3625
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 183-214 1.24e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 53.41  E-value: 1.24e-08
                            10        20        30
                    ....*....|....*....|....*....|..
gi 126012573    183 CLHNEFSCGNGECIPRAYVCDHDNDCQDGSDE 214
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1066-1098 1.25e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 53.02  E-value: 1.25e-08
                            10        20        30
                    ....*....|....*....|....*....|...
gi 126012573   1066 TCSSSAFTCGHGECIPAHWRCDKRNDCVDGSDE 1098
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
2863-2895 1.34e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 53.41  E-value: 1.34e-08
                           10        20        30
                   ....*....|....*....|....*....|...
gi 126012573  2863 TCSSSEFQCASGRCIPQHWYCDQETDCFDASDE 2895
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 2545-2585 1.41e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 53.37  E-value: 1.41e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 126012573   2545 IVNSSLVMPSGLTLDYEEDLLYWVDASLQRIERSTLTGVDR 2585
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1026-1060 1.46e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 52.98  E-value: 1.46e-08
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 126012573 1026 CGLFSFPCKNGRCVPNYYLCDGVDDCHDNSDEQLC 1060
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2863-2895 1.50e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 53.02  E-value: 1.50e-08
                            10        20        30
                    ....*....|....*....|....*....|...
gi 126012573   2863 TCSSSEFQCASGRCIPQHWYCDQETDCFDASDE 2895
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3717-3754 1.71e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 53.02  E-value: 1.71e-08
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 126012573  3717 RTCHPvGDFRCKNHHCIPLRWQCDGQNDCGDNSDEENC 3754
Cdd:pfam00057    1 STCSP-NEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 221-253 1.82e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 52.64  E-value: 1.82e-08
                            10        20        30
                    ....*....|....*....|....*....|...
gi 126012573    221 TCGGYQFTCPSGRCIYQNWVCDGEDDCKDNGDE 253
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2992-3024 1.93e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 52.64  E-value: 1.93e-08
                            10        20        30
                    ....*....|....*....|....*....|...
gi 126012573   2992 TCSENEFTCGYGLCIPKIFRCDRHNDCGDYSDE 3024
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3074-3106 2.21e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 52.64  E-value: 2.21e-08
                            10        20        30
                    ....*....|....*....|....*....|...
gi 126012573   3074 TCPPHEFKCDNGRCIEMMKLCNHLDDCLDNSDE 3106
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3633-3666 2.25e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 52.64  E-value: 2.25e-08
                           10        20        30
                   ....*....|....*....|....*....|....
gi 126012573  3633 RTCRPGQFRCANGRCIPQAWKCDVDNDCGDHSDE 3666
Cdd:pfam00057    1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3512-3544 2.49e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 52.25  E-value: 2.49e-08
                            10        20        30
                    ....*....|....*....|....*....|...
gi 126012573   3512 CSSTQFLCANNeKCIPIWWKCDGQKDCSDGSDE 3544
Cdd:smart00192    2 CPPGEFQCDNG-RCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 551-591 2.66e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 52.60  E-value: 2.66e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 126012573    551 LVKTKLGWPAGVTLDMISKRVYWVDSRFDYIETVTYDGIQR 591
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3512-3545 3.33e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 52.21  E-value: 3.33e-08
                          10        20        30
                  ....*....|....*....|....*....|....
gi 126012573 3512 CSSTQFLCANNeKCIPIWWKCDGQKDCSDGSDEL 3545
Cdd:cd00112     1 CPPNEFRCANG-RCIPSSWVCDGEDDCGDGSDEE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1109-1140 3.43e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 51.87  E-value: 3.43e-08
                            10        20        30
                    ....*....|....*....|....*....|..
gi 126012573   1109 CLDTQYTCDNHQCISKNWVCDTDNDCGDGSDE 1140
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2740-2772 3.90e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 51.87  E-value: 3.90e-08
                            10        20        30
                    ....*....|....*....|....*....|...
gi 126012573   2740 TCSPTAFTCANGRCVQYSYRCDYYNDCGDGSDE 2772
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1025-1057 4.26e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 51.87  E-value: 4.26e-08
                            10        20        30
                    ....*....|....*....|....*....|...
gi 126012573   1025 QCGLFSFPCKNGRCVPNYYLCDGVDDCHDNSDE 1057
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3031-3064 4.89e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 51.48  E-value: 4.89e-08
                           10        20        30
                   ....*....|....*....|....*....|....
gi 126012573  3031 TCQQNQFTCQNGRCISKTFVCDEDNDCGDGSDEL 3064
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEE 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 27-59 5.33e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 51.48  E-value: 5.33e-08
                            10        20        30
                    ....*....|....*....|....*....|...
gi 126012573     27 ECDSAHFRCGSGHCIPADWRCDGTKDCSDDADE 59
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 3262-3304 6.30e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 51.45  E-value: 6.30e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 126012573   3262 ETIINHRLPAAESLAVDWVSRKLYWLDARLDGLFVSDLNGGHR 3304
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3798-3832 6.48e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 51.05  E-value: 6.48e-08
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 126012573 3798 CHPEYFQCTSGHCVHSELKCDGSADCLDASDEADC 3832
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 776-818 7.37e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 51.45  E-value: 7.37e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 126012573    776 EILAANRVENVESLAFDWISKNLYWTDSHYKSISVMRLADKTR 818
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 107-139 7.89e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 51.09  E-value: 7.89e-08
                            10        20        30
                    ....*....|....*....|....*....|...
gi 126012573    107 TCSSHQITCSNGQCIPSEYRCDHVRDCPDGADE 139
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
2740-2775 8.62e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 51.10  E-value: 8.62e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 126012573  2740 TCSPTAFTCANGRCVQYSYRCDYYNDCGDGSDEAGC 2775
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1883-1928 8.67e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 51.01  E-value: 8.67e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 126012573  1883 GKLYWsdqgTDSGVPAKIASANMDGTSVKTLFTGNLEHLECVTLDI 1928
Cdd:pfam00058    1 GRLYW----TDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
2991-3027 1.05e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 50.71  E-value: 1.05e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 126012573  2991 RTCSENEFTCGYGLCIPKIFRCDRHNDCGDYSDERGC 3027
Cdd:pfam00057    1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 3321-3355 1.27e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 50.68  E-value: 1.27e-07
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 126012573   3321 DNPRGLALHPQYGYLYWADWGhRAYIGRVGMDGTN 3355
Cdd:smart00135    9 GHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTN 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 2227-2267 1.30e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 50.68  E-value: 1.30e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 126012573   2227 VLVSEGIVTPRGLAVDRSDGYVYWVDDSLDIIARIRINGEN 2267
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
2091-2252 1.38e-07

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 55.86  E-value: 1.38e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012573 2091 AGQGRNALHVDVDVSSGFIYWCDfsssvASDNAIRRIKPDGSSLMNIVTHGigeNGVRGIAVDWVAGNLYFTNAFVSEtl 2170
Cdd:COG3391    64 AAAVADADGADAGADGRRLYVAN-----SGSGRVSVIDLATGKVVATIPVG---GGPRGLAVDPDGGRLYVADSGNGR-- 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012573 2171 ieVLRINTTYRRVLLKVTV-DMPRHIVVDPKNRYLFWADYGQrPKIER--SFLDCTNRTVL--VSEGiVTPRGLAVDRSD 2245
Cdd:COG3391   134 --VSVIDTATGKVVATIPVgAGPHGIAVDPDGKRLYVANSGS-NTVSVivSVIDTATGKVVatIPVG-GGPVGVAVSPDG 209


                  ....*..
gi 126012573 2246 GYVYWVD 2252
Cdd:COG3391   210 RRLYVAN 216
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1521-1561 1.47e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 50.24  E-value: 1.47e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 126012573  1521 RNLYWTDYALE-TIEVSKIDGSHRTVLISKNLTNPRGLALDP 1561
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 838-879 1.51e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 50.24  E-value: 1.51e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 126012573   838 GYLFFTDWFRPAKIMRAWSDGSHLLPVINTTLGWPNGLAIDW 879
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 4177-4220 1.52e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 50.29  E-value: 1.52e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 126012573   4177 KWLISTDLDQPAAIAVNPKLGLMFWTDWGkEPKIESAWMNGEDR 4220
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTNR 43
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3074-3109 1.61e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 50.32  E-value: 1.61e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 126012573  3074 TCPPHEFKCDNGRCIEMMKLCNHLDDCLDNSDEKGC 3109
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1567-1607 1.62e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 50.24  E-value: 1.62e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 126012573  1567 LLFWSDWGHHPRIERASMDGSMRTVIVQDKIFWPCGLTIDY 1607
Cdd:pfam00058    2 RLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2864-2895 1.63e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 50.28  E-value: 1.63e-07
                          10        20        30
                  ....*....|....*....|....*....|..
gi 126012573 2864 CSSSEFQCASGRCIPQHWYCDQETDCFDASDE 2895
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 2182-2225 1.74e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 50.29  E-value: 1.74e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 126012573   2182 RVLLKVTVDMPRHIVVDPKNRYLFWADYGqRPKIERSFLDCTNR 2225
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTNR 43
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 2091-2300 1.92e-07

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 55.79  E-value: 1.92e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012573 2091 AGQGRNALHVDVDvSSGFIYWCDfsssvASDNAIRRIKPDGSSLMNIVTHGIGE---NGVRGIAVDwVAGNLYftnafVS 2167
Cdd:cd05819    51 DGQFNEPAGVAVD-SDGNLYVAD-----TGNHRIQKFDPDGNFLASFGGSGDGDgefNGPRGIAVD-SSGNIY-----VA 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012573 2168 ETL---IEVLRINTTYRRVLLKVTVDM-----PRHIVVDPKNrYLFWADYGQRpKIERSFLDCTNRTVLVSEGIV----- 2234
Cdd:cd05819   119 DTGnhrIQKFDPDGEFLTTFGSGGSGPgqfngPTGVAVDSDG-NIYVADTGNH-RIQVFDPDGNFLTTFGSTGTGpgqfn 196

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 126012573 2235 TPRGLAVDrSDGYVYwVDDSLDiiARIRI-NGENSEVIRYGSRYPT------PYGITVF-ENSIIWVDRNLKKI 2300
Cdd:cd05819   197 YPTGIAVD-SDGNIY-VADSGN--NRVQVfDPDGAGFGGNGNFLGSdgqfnrPSGLAVDsDGNLYVADTGNNRI 266
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
2699-2731 1.98e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 49.94  E-value: 1.98e-07
                           10        20        30
                   ....*....|....*....|....*....|...
gi 126012573  2699 RCGASSFTCSNGRCISEEWKCDNDNDCGDGSDE 2731
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
221-256 2.41e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 49.55  E-value: 2.41e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 126012573   221 TCGGYQFTCPSGRCIYQNWVCDGEDDCKDNGDEDGC 256
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1187-1222 3.23e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 49.13  E-value: 3.23e-07
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 126012573 1187 CTASQFKCASGdKCIGVTNRCDGVFDCSDNSDEAGC 1222
Cdd:cd00112     1 CPPNEFRCANG-RCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3797-3829 3.39e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 49.17  E-value: 3.39e-07
                            10        20        30
                    ....*....|....*....|....*....|...
gi 126012573   3797 TCHPEYFQCTSGHCVHSELKCDGSADCLDASDE 3829
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
28-62 3.64e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 49.17  E-value: 3.64e-07
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 126012573    28 CDSAHFRCGSGHCIPADWRCDGTKDCSDDADEIGC 62
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3928-3959 3.78e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 49.17  E-value: 3.78e-07
                            10        20        30
                    ....*....|....*....|....*....|..
gi 126012573   3928 CTEYEYKCGNGHCIPHDNVCDDADDCGDWSDE 3959
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2948-2988 4.33e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 48.74  E-value: 4.33e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 126012573 2948 CSDSEFLCVNdrppdRRCIPQSWVCDGDVDCTDGYDEnQNC 2988
Cdd:cd00112     1 CPPNEFRCAN-----GRCIPSSWVCDGEDDCGDGSDE-ENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 2459-2500 5.38e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 48.75  E-value: 5.38e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 126012573   2459 TVIASGIGTADGIAFDWITRRIYYSDYLNQMINSMAEDGSNR 2500
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 3219-3260 6.36e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 48.75  E-value: 6.36e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 126012573   3219 YSLILEGLDNVVALDFDRVEKRLYWIDTQRQVIERMFLNKTN 3260
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1230-1264 7.00e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 48.36  E-value: 7.00e-07
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 126012573 1230 CHSDEFQCQeDGICIPNFWECDGHPDCLYGSDEHN 1264
Cdd:cd00112     1 CPPNEFRCA-NGRCIPSSWVCDGEDDCGDGSDEEN 34
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3796-3832 7.73e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 48.40  E-value: 7.73e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 126012573  3796 RTCHPEYFQCTSGHCVHSELKCDGSADCLDASDEADC 3832
Cdd:pfam00057    1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3682-3714 9.11e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 47.97  E-value: 9.11e-07
                          10        20        30
                  ....*....|....*....|....*....|...
gi 126012573 3682 TEFSCKtNYRCIPKWAVCNGVDDCRDNSDEQGC 3714
Cdd:cd00112     4 NEFRCA-NGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1591-1632 1.01e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 47.98  E-value: 1.01e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 126012573   1591 VIVQDKIFWPCGLTIDYPNRLLYFMDSYLDYMDFCDYNGHHR 1632
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
2086-2285 1.04e-06

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 53.16  E-value: 1.04e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012573 2086 TMVPVAGQGRNALHVDVDVSSGFIYWCDFSSSVASDNAIRRIKPDGSSLMNIVTHGIGENGVRGIAV--DWVAGN-LYFT 2162
Cdd:COG3391     6 SLLVAVLLAVLALAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGadAGADGRrLYVA 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012573 2163 NAFVSEtlieVLRINTTYRRVLLKVTV-DMPRHIVVDPKNRYLFWADYGQRpKIerSFLDCTNRTVL--VSEGiVTPRGL 2239
Cdd:COG3391    86 NSGSGR----VSVIDLATGKVVATIPVgGGPRGLAVDPDGGRLYVADSGNG-RV--SVIDTATGKVVatIPVG-AGPHGI 157

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 126012573 2240 AVDRSDGYVYWVDDSLDIIARI--RINGENSEVIRYGSRYPTPYGITV 2285
Cdd:COG3391   158 AVDPDGKRLYVANSGSNTVSVIvsVIDTATGKVVATIPVGGGPVGVAV 205
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3885-3915 1.36e-06

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 47.63  E-value: 1.36e-06
                            10        20        30
                    ....*....|....*....|....*....|.
gi 126012573   3885 SPNRFRCDNNRCIYSHEVCNGVDDCGDGTDE 3915
Cdd:smart00192    3 PPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2948-2984 1.38e-06

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 47.24  E-value: 1.38e-06
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 126012573   2948 CSDSEFLCVNdrppdRRCIPQSWVCDGDVDCTDGYDE 2984
Cdd:smart00192    2 CPPGEFQCDN-----GRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1230-1262 1.43e-06

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 47.24  E-value: 1.43e-06
                            10        20        30
                    ....*....|....*....|....*....|...
gi 126012573   1230 CHSDEFQCQeDGICIPNFWECDGHPDCLYGSDE 1262
Cdd:smart00192    2 CPPGEFQCD-NGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1109-1143 1.43e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 47.63  E-value: 1.43e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 126012573  1109 CLDTQYTCDNHQCISKNWVCDTDNDCGDGSDEKNC 1143
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
106-142 1.46e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 47.63  E-value: 1.46e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 126012573   106 STCSSHQITCSNGQCIPSEYRCDHVRDCPDGADENDC 142
Cdd:pfam00057    1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3885-3915 1.50e-06

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 47.20  E-value: 1.50e-06
                          10        20        30
                  ....*....|....*....|....*....|.
gi 126012573 3885 SPNRFRCDNNRCIYSHEVCNGVDDCGDGTDE 3915
Cdd:cd00112     2 PPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 3282-3330 1.58e-06

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 47.54  E-value: 1.58e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 126012573  3282 RKLYWLDARLD-GLFVSDLNGGHRRMLAQHcvdanntfCFDNPRGLALHP 3330
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTD--------DLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 2500-2542 1.66e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 47.60  E-value: 1.66e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 126012573   2500 RTVIAR-VPKPRAIVLDPCQGYLYWADWDTHaKIERATLGGNFR 2542
Cdd:smart00135    1 RTLLSSgLGHPNGLAVDWIEGRLYWTDWGLD-VIEVANLDGTNR 43
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3759-3793 1.80e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 47.24  E-value: 1.80e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 126012573  3759 CTESEFRCVNQQCIPSRWICDHYNDCGDNSDERDC 3793
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1911-1953 1.96e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 47.21  E-value: 1.96e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 126012573   1911 KTLFTGNLEHLECVTLDIEEQKLYWAVTGRGVIERGNVDGTDR 1953
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1869-1910 2.08e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 47.21  E-value: 2.08e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 126012573   1869 GVGFPIGITVDPARGKLYWSDQGTDsgvpaKIASANMDGTSV 1910
Cdd:smart00135    7 GLGHPNGLAVDWIEGRLYWTDWGLD-----VIEVANLDGTNR 43
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1353-1388 3.24e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 46.47  E-value: 3.24e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 126012573  1353 CSDFNGGCTHECVQEPFGAKCLCPLGFLLANDSKTC 1388
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 2519-2560 3.26e-06

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 46.77  E-value: 3.26e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 126012573  2519 GYLYWADWDTHAKIERATLGGNFRVPIVNSSLVMPSGLTLDY 2560
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3594-3625 3.86e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 46.09  E-value: 3.86e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 126012573  3594 CDSNEWQCANKRCIPESWQCDTFNDCEDNSDE 3625
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3926-3962 4.01e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 46.09  E-value: 4.01e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 126012573  3926 KPCTEYEYKCGNGHCIPHDNVCDDADDCGDWSDELGC 3962
Cdd:pfam00057    1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 2022-2058 4.06e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 46.08  E-value: 4.06e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 126012573  2022 CSNNMNACQQICLPVPGGlFSCACATGFKLNPDNRSC 2058
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGG-YTCSCPEGYELQDDGRTC 36
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2784-2817 4.37e-06

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 46.05  E-value: 4.37e-06
                          10        20        30
                  ....*....|....*....|....*....|....
gi 126012573 2784 TEFMCNNRRCIPREFICNGVDNCHDNntSDEKNC 2817
Cdd:cd00112     4 NEFRCANGRCIPSSWVCDGEDDCGDG--SDEENC 35
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
394-579 4.88e-06

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 51.23  E-value: 4.88e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012573  394 ASIIFSNGRDLLIGDIHGRSFRILVESQNRGVAVGVAFHYHL--QRVFWTDTVQNKVFSVDINGLNIQEVLNVSVEtPEN 471
Cdd:COG3391    36 LLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGAdgRRLYVANSGSGRVSVIDLATGKVVATIPVGGG-PRG 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012573  472 LAVDWVNNKIYLVETKVNRIDMVNL-DGSYRVTLITENlgHPRGIAVDPTVGYLFFSDWeslsGEPKLER--AFMDGSNR 548
Cdd:COG3391   115 LAVDPDGGRLYVADSGNGRVSVIDTaTGKVVATIPVGA--GPHGIAVDPDGKRLYVANS----GSNTVSVivSVIDTATG 188

                         170       180       190
                  ....*....|....*....|....*....|..
gi 126012573  549 KDLVKTKLG-WPAGVTLDMISKRVYWVDSRFD 579
Cdd:COG3391   189 KVVATIPVGgGPVGVAVSPDGRRLYVANRGSN 220
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
2392-2630 6.09e-06

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 51.17  E-value: 6.09e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012573 2392 FALSNSLRSLHLDPENHSppFQTINVER----TVMSLDYDsvsDRIYFTQNLASGVGQISYATlssgiHTPTVIASGIGT 2467
Cdd:COG4257    32 FTDQGGGRIGRLDPATGE--FTEYPLGGgsgpHGIAVDPD---GNLWFTDNGNNRIGRIDPKT-----GEITTFALPGGG 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012573 2468 AD--GIAFD-----WITrriyysdylNQMINSMAE-DGSNRTVIA-RVPK----PRAIVLDPcQGYLYWADWDTHA--KI 2532
Cdd:COG4257   102 SNphGIAFDpdgnlWFT---------DQGGNRIGRlDPATGEVTEfPLPTggagPYGIAVDP-DGNLWVTDFGANAigRI 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012573 2533 ERATlgGNFRVPIVNSSLVMPSGLTLDyEEDLLYWVDA---SLQRIerSTLTGVDREVIV-NAAVHAFGLTLYGQ-YIYW 2607
Cdd:COG4257   172 DPDT--GTLTEYALPTPGAGPRGLAVD-PDGNLWVADTgsgRIGRF--DPKTGTVTEYPLpGGGARPYGVAVDGDgRVWF 246

                         250       260
                  ....*....|....*....|...
gi 126012573 2608 TDLYTQRIYRankYDGSGQIAMT 2630
Cdd:COG4257   247 AESGANRIVR---FDPDTELTEY 266
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2821-2854 6.11e-06

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 45.70  E-value: 6.11e-06
                            10        20        30
                    ....*....|....*....|....*....|....
gi 126012573   2821 TCQSGYTKCHNSNiCIPRVYLCDGDNDCGDNSDE 2854
Cdd:smart00192    1 TCPPGEFQCDNGR-CIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 4154-4194 6.86e-06

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 45.61  E-value: 6.86e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 126012573  4154 RHIYWSDVKNK-RIEVAKLDGRYRKWLISTDLDQPAAIAVNP 4194
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 3121-3150 7.04e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 45.31  E-value: 7.04e-06
                           10        20        30
                   ....*....|....*....|....*....|
gi 126012573  3121 GCDHNCTDTLTSFYCSCRPGYKLMSDKRTC 3150
Cdd:pfam14670    7 GCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1025-1060 8.97e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 45.32  E-value: 8.97e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 126012573  1025 QCGLFSFPCKNGRCVPNYYLCDGVDDCHDNSDEQLC 1060
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
2236-2544 9.15e-06

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 50.79  E-value: 9.15e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012573 2236 PRGLAVDRsDGYVYWVDDSLDIIARIRINGENSEVIRYGSRyPTPYGITVFENSIIWV-DRNLKKIFQaskepenteppt 2314
Cdd:COG4257    19 PRDVAVDP-DGAVWFTDQGGGRIGRLDPATGEFTEYPLGGG-SGPHGIAVDPDGNLWFtDNGNNRIGR------------ 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012573 2315 virdninwlrdVTIFDKQVQprspaevnnnpclennggcshlCFALPGLHTPKCDCAFGtlqSDGKncaistenfLIFAL 2394
Cdd:COG4257    85 -----------IDPKTGEIT----------------------TFALPGGGSNPHGIAFD---PDGN---------LWFTD 119

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012573 2395 SNSLRSLHLDPENHSppFQTINVERTV---MSLDYDSvSDRIYFTQNLASGVGQISYATLSSGIHT-PTVIA--SGIG-T 2467
Cdd:COG4257   120 QGGNRIGRLDPATGE--VTEFPLPTGGagpYGIAVDP-DGNLWVTDFGANAIGRIDPDTGTLTEYAlPTPGAgpRGLAvD 196

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012573 2468 ADGiafdwitrRIYYSDYLN---QMINsmAEDGSNRTVI--ARVPKPRAIVLDPcQGYLYWADWDTH--AKIERATLGGN 2540
Cdd:COG4257   197 PDG--------NLWVADTGSgriGRFD--PKTGTVTEYPlpGGGARPYGVAVDG-DGRVWFAESGANriVRFDPDTELTE 265


                  ....
gi 126012573 2541 FRVP 2544
Cdd:COG4257   266 YVLP 269
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 461-501 1.07e-05

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 45.29  E-value: 1.07e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 126012573    461 VLNVSVETPENLAVDWVNNKIYLVETKVNRIDMVNLDGSYR 501
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
EGF_CA smart00179
Calcium-binding EGF-like domain;
4007-4047 1.27e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.93  E-value: 1.27e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 126012573   4007 DINECEQFGTCPQH--CRNTKGSYECVCADGFTSmsdrpGKRC 4047
Cdd:smart00179    1 DIDECASGNPCQNGgtCVNTVGSYRCECPPGYTD-----GRNC 38
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1187-1219 1.45e-05

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 44.55  E-value: 1.45e-05
                            10        20        30
                    ....*....|....*....|....*....|...
gi 126012573   1187 CTASQFKCASGdKCIGVTNRCDGVFDCSDNSDE 1219
Cdd:smart00192    2 CPPGEFQCDNG-RCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3682-3711 1.63e-05

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 44.55  E-value: 1.63e-05
                            10        20        30
                    ....*....|....*....|....*....|
gi 126012573   3682 TEFSCKtNYRCIPKWAVCNGVDDCRDNSDE 3711
Cdd:smart00192    5 GEFQCD-NGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1230-1264 1.65e-05

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 44.55  E-value: 1.65e-05
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 126012573  1230 CHSDEFQCQeDGICIPNFWECDGHPDCLYGSDEHN 1264
Cdd:pfam00057    3 CSPNEFQCG-SGECIPRSWVCDGDPDCGDGSDEEN 36
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 2346-2382 1.86e-05

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 44.16  E-value: 1.86e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 126012573  2346 CLENNGGCSHLCFALPGLHTpkCDCAFG-TLQSDGKNC 2382
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYT--CSCPEGyELQDDGRTC 36
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 490-519 2.02e-05

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 44.46  E-value: 2.02e-05
                           10        20        30
                   ....*....|....*....|....*....|
gi 126012573   490 RIDMVNLDGSYRVTLITENLGHPRGIAVDP 519
Cdd:pfam00058   13 SISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 3147-3190 2.09e-05

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 48.92  E-value: 2.09e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 126012573 3147 KRTCVDIDECTEMPFVCSQKCENVIGSYICKCAPGYLREPDGKT 3190
Cdd:cd01475   181 GKICVVPDLCATLSHVCQQVCISTPGSYLCACTEGYALLEDNKT 224
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2784-2814 2.34e-05

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 43.78  E-value: 2.34e-05
                            10        20        30
                    ....*....|....*....|....*....|.
gi 126012573   2784 TEFMCNNRRCIPREFICNGVDNCHDNntSDE 2814
Cdd:smart00192    5 GEFQCDNGRCIPSSWVCDGVDDCGDG--SDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
2948-2988 3.21e-05

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 43.78  E-value: 3.21e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 126012573  2948 CSDSEFLCvndrpPDRRCIPQSWVCDGDVDCTDGYDEnQNC 2988
Cdd:pfam00057    3 CSPNEFQC-----GSGECIPRSWVCDGDPDCGDGSDE-ENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2822-2855 3.23e-05

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 43.73  E-value: 3.23e-05
                          10        20        30
                  ....*....|....*....|....*....|....
gi 126012573 2822 CQSGYTKCHNSNiCIPRVYLCDGDNDCGDNSDEN 2855
Cdd:cd00112     1 CPPNEFRCANGR-CIPSSWVCDGEDDCGDGSDEE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3512-3545 3.51e-05

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 43.39  E-value: 3.51e-05
                           10        20        30
                   ....*....|....*....|....*....|....
gi 126012573  3512 CSSTQFLCANNEkCIPIWWKCDGQKDCSDGSDEL 3545
Cdd:pfam00057    3 CSPNEFQCGSGE-CIPRSWVCDGDPDCGDGSDEE 35
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
744-893 4.07e-05

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 48.54  E-value: 4.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012573  744 VGIDFDAQDSTIFFSDMSKHMIfkQKIDGTGREILAANRV-ENVESLAFDWISKNLYWTDSHYKSISVMRLADKTRRTVV 822
Cdd:COG3391    71 DGADAGADGRRLYVANSGSGRV--SVIDLATGKVVATIPVgGGPRGLAVDPDGGRLYVADSGNGRVSVIDTATGKVVATI 148

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 126012573  823 QYLNNPRSVVVHPFAGYLFFTDWFRP--AKIMRAW--SDGShllpVINT--TLGWPNGLAIDWAASRLYWVDAYFDK 893
Cdd:COG3391   149 PVGAGPHGIAVDPDGKRLYVANSGSNtvSVIVSVIdtATGK----VVATipVGGGPVGVAVSPDGRRLYVANRGSNT 221
cEGF pfam12662
Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved ...
 3134-3155 4.66e-05

Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteriztic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue.


Pssm-ID: 463661  Cd Length: 22  Bit Score: 42.78  E-value: 4.66e-05
                           10        20
                   ....*....|....*....|..
gi 126012573  3134 YCSCRPGYKLMSDKRTCVDIDE 3155
Cdd:pfam12662    1 TCSCPPGYQLDPDGRTCVDIDE 22
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 2202-2242 4.79e-05

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 43.30  E-value: 4.79e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 126012573  2202 RYLFWADYGQRPKIERSFLDCTNRTVLVSEGIVTPRGLAVD 2242
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
EGF_CA smart00179
Calcium-binding EGF-like domain;
1390-1429 5.13e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.00  E-value: 5.13e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 126012573   1390 DIDECDILGSCSQH--CYNMRGSFRCSCDTGYmleSDGRTCK 1429
Cdd:smart00179    1 DIDECASGNPCQNGgtCVNTVGSYRCECPPGY---TDGRNCE 39
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
2820-2854 6.91e-05

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 42.62  E-value: 6.91e-05
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 126012573  2820 RTCQSGYTKCHnSNICIPRVYLCDGDNDCGDNSDE 2854
Cdd:pfam00057    1 STCSPNEFQCG-SGECIPRSWVCDGDPDCGDGSDE 34
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1398-1428 7.49e-05

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 42.61  E-value: 7.49e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 126012573  1398 GSCSQHCYNMRGSFRCSCDTGYMLESDGRTC 1428
Cdd:pfam14670    6 GGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 4007-4047 7.62e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.62  E-value: 7.62e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 126012573 4007 DINECEQFGTCPQH--CRNTKGSYECVCADGFTsmsdrpGKRC 4047
Cdd:cd00054     1 DIDECASGNPCQNGgtCVNTVGSYRCSCPPGYT------GRNC 37
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 522-565 1.17e-04

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 42.15  E-value: 1.17e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 126012573   522 GYLFFSDWESlsgEPKLERAFMDGSNRKDLVKTKLGWPAGVTLD 565
Cdd:pfam00058    1 GRLYWTDSSL---RASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
2094-2210 1.24e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 47.00  E-value: 1.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012573 2094 GRNALHVDVDVSSGFIYWCDFSssvasDNAIRRIKPDGSSLMNIVTHGigeNGVRGIAVDWVAGNLYFTNAFVSETLIEV 2173
Cdd:COG3391   109 GGGPRGLAVDPDGGRLYVADSG-----NGRVSVIDTATGKVVATIPVG---AGPHGIAVDPDGKRLYVANSGSNTVSVIV 180

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 126012573 2174 LRINTTYRRVLLKVTV-DMPRHIVVDPKNRYLFWADYG 2210
Cdd:COG3391   181 SVIDTATGKVVATIPVgGGPVGVAVSPDGRRLYVANRG 218
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
2143-2314 1.36e-04

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 46.94  E-value: 1.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012573 2143 GENGVRGIAVDwVAGNLYFTNAFVSEtlIEVLRINTTYRRVLLKVTVDMPRHIVVDPKNRyLFWADYGQRpKIERsfLDC 2222
Cdd:COG4257    15 PGSGPRDVAVD-PDGAVWFTDQGGGR--IGRLDPATGEFTEYPLGGGSGPHGIAVDPDGN-LWFTDNGNN-RIGR--IDP 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012573 2223 TN---RTVLVSEGIVTPRGLAVDrSDGYVYWVDDSLDIIARIRINGENSEVIRYGSRYPTPYGITVFENSIIWV----DR 2295
Cdd:COG4257    88 KTgeiTTFALPGGGSNPHGIAFD-PDGNLWFTDQGGNRIGRLDPATGEVTEFPLPTGGAGPYGIAVDPDGNLWVtdfgAN 166

                         170
                  ....*....|....*....
gi 126012573 2296 NLKKIFQASKEPENTEPPT 2314
Cdd:COG4257   167 AIGRIDPDTGTLTEYALPT 185
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 266-300 1.53e-04

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 41.81  E-value: 1.53e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 126012573  266 CSPREWSCPeSGRCISIYKVCDGILDCPGREDENN 300
Cdd:cd00112     1 CPPNEFRCA-NGRCIPSSWVCDGEDDCGDGSDEEN 34
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3553-3584 1.54e-04

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 41.46  E-value: 1.54e-04
                            10        20        30
                    ....*....|....*....|....*....|..
gi 126012573   3553 CRLGQFQCSDGNCTSPQTLCNAHQNCPDGSDE 3584
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 3377-3417 1.72e-04

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 41.76  E-value: 1.72e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 126012573  3377 DLLYWADAHLGY-IEYSDLEGHHRHTVYDGALPHPFAITIFE 3417
Cdd:pfam00058    1 GRLYWTDSSLRAsISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 149-179 1.77e-04

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 41.42  E-value: 1.77e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 126012573  149 QLTCDNGACYNTSQKCDWKVDCRDSSDEINC 179
Cdd:cd00112     5 EFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 429-519 1.91e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 46.52  E-value: 1.91e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012573  429 VAFHYHLQRVFWTDTVQNKVFSVDINGLNIQEVLNVSVET-----PENLAVDwVNNKIYLVETKVNRIDMVNLDGSYRVT 503
Cdd:cd14963   105 AGLAIDDGKLYVSDVKKHKVIVFDLEGKLLLEFGKPGSEPgelsyPNGIAVD-EDGNIYVADSGNGRIQVFDKNGKFIKE 183

                          90       100
                  ....*....|....*....|.
gi 126012573  504 L-----ITENLGHPRGIAVDP 519
Cdd:cd14963   184 LngspdGKSGFVNPRGIAVDP 204
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 3408-3441 2.30e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 41.43  E-value: 2.30e-04
                            10        20        30
                    ....*....|....*....|....*....|....
gi 126012573   3408 PHPFAITIFEDTIYWTDWNTRTVEKgNKYDGSNR 3441
Cdd:smart00135   11 PNGLAVDWIEGRLYWTDWGLDVIEV-ANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 818-860 2.61e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 41.43  E-value: 2.61e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 126012573    818 RRTVVQYLNNPRSVVVHPFAGYLFFTDWFRPaKIMRAWSDGSH 860
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLD-VIEVANLDGTN 42
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
3282-3434 2.93e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 45.84  E-value: 2.93e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012573 3282 RKLYWLDARLDGLFVSDLNGGhrRMLAQHCVDanntfcfDNPRGLALHPQYGYLYWADWG-HRAYIgrvgMDGTNKSVII 3360
Cdd:COG3391    80 RRLYVANSGSGRVSVIDLATG--KVVATIPVG-------GGPRGLAVDPDGGRLYVADSGnGRVSV----IDTATGKVVA 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012573 3361 STKL-EWPNGITIDYTNDLLYWADAHLGYIeyS------DLE-GHHRHTVYDGALPHPFAITIFEDTIYWTDWNTRTVEK 3432
Cdd:COG3391   147 TIPVgAGPHGIAVDPDGKRLYVANSGSNTV--SvivsviDTAtGKVVATIPVGGGPVGVAVSPDGRRLYVANRGSNTSNG 224


                  ..
gi 126012573 3433 GN 3434
Cdd:COG3391   225 GS 226
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3885-3920 3.60e-04

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 40.69  E-value: 3.60e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 126012573  3885 SPNRFRCDNNRCIYSHEVCNGVDDCGDGTDetEEHC 3920
Cdd:pfam00057    4 SPNEFQCGSGECIPRSWVCDGDPDCGDGSD--EENC 37
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 3469-3498 4.26e-04

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 40.30  E-value: 4.26e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 126012573  3469 CGTNNGGCSHLCLIKPGgkGFTCECPDDFR 3498
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPG--GYTCSCPEGYE 28
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3553-3585 4.49e-04

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 40.27  E-value: 4.49e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 126012573 3553 CRLGQFQCSDGNCTSPQTLCNAHQNCPDGSDED 3585
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 265-298 4.76e-04

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 40.31  E-value: 4.76e-04
                            10        20        30
                    ....*....|....*....|....*....|....
gi 126012573    265 KCSPREWSCPeSGRCISIYKVCDGILDCPGREDE 298
Cdd:smart00192    1 TCPPGEFQCD-NGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
2785-2817 5.88e-04

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 39.92  E-value: 5.88e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 126012573  2785 EFMCNNRRCIPREFICNGVDNCHDNntSDEKNC 2817
Cdd:pfam00057    7 EFQCGSGECIPRSWVCDGDPDCGDG--SDEENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3683-3714 6.18e-04

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 39.92  E-value: 6.18e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 126012573  3683 EFSCKTNyRCIPKWAVCNGVDDCRDNSDEQGC 3714
Cdd:pfam00057    7 EFQCGSG-ECIPRSWVCDGDPDCGDGSDEENC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
3152-3191 8.03e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.92  E-value: 8.03e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 126012573   3152 DIDECTEMPfVCSQ--KCENVIGSYICKCAPGYLrepDGKTC 3191
Cdd:smart00179    1 DIDECASGN-PCQNggTCVNTVGSYRCECPPGYT---DGRNC 38
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 4119-4254 8.40e-04

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 44.62  E-value: 8.40e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012573 4119 YIPNFEsgrNNLVQEVDLKLKYVMQ-------------PDGIAVDWVGrHIYWSDVKNKRIEVAKLDGRY-RKW----LI 4180
Cdd:cd05819   116 YVADTG---NHRIQKFDPDGEFLTTfgsggsgpgqfngPTGVAVDSDG-NIYVADTGNHRIQVFDPDGNFlTTFgstgTG 191

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012573 4181 STDLDQPAAIAVNPKlGLMFWTDWG-----KEPKIESAWM-NGEDRNilVFEDLGWPTGLSIDylNNDRIYWSDFKEDVI 4254
Cdd:cd05819   192 PGQFNYPTGIAVDSD-GNIYVADSGnnrvqVFDPDGAGFGgNGNFLG--SDGQFNRPSGLAVD--SDGNLYVADTGNNRI 266
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1390-1429 8.55e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.54  E-value: 8.55e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 126012573 1390 DIDECDILGSCSQH--CYNMRGSFRCSCDTGYMlesdGRTCK 1429
Cdd:cd00054     1 DIDECASGNPCQNGgtCVNTVGSYRCSCPPGYT----GRNCE 38
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1311-1344 9.20e-04

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 39.54  E-value: 9.20e-04
                            10        20        30
                    ....*....|....*....|....*....|....
gi 126012573   1311 RCPSWQWQClGHNICVNLSVVCDGIFDCPNGTDE 1344
Cdd:smart00192    1 TCPPGEFQC-DNGRCIPSSWVCDGVDDCGDGSDE 33
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 423-576 9.69e-04

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 44.62  E-value: 9.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012573  423 RGVAVGvafhyHLQRVFWTDTVQNKVFSVDINGlNIQEVL------NVSVETPENLAVDwVNNKIYLVETKVNRIDMVNL 496
Cdd:cd05819   105 RGIAVD-----SSGNIYVADTGNHRIQKFDPDG-EFLTTFgsggsgPGQFNGPTGVAVD-SDGNIYVADTGNHRIQVFDP 177

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012573  497 DGSYRVTLITENLG-----HPRGIAVDPTvGYLFFSDWE-------SLSGepklerAFMDGSNRKDLVKTKLGWPAGVTL 564
Cdd:cd05819   178 DGNFLTTFGSTGTGpgqfnYPTGIAVDSD-GNIYVADSGnnrvqvfDPDG------AGFGGNGNFLGSDGQFNRPSGLAV 250

                         170
                  ....*....|..
gi 126012573  565 DmISKRVYWVDS 576
Cdd:cd05819   251 D-SDGNLYVADT 261
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1187-1222 9.81e-04

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 39.54  E-value: 9.81e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 126012573  1187 CTASQFKCASGdKCIGVTNRCDGVFDCSDNSDEAGC 1222
Cdd:pfam00057    3 CSPNEFQCGSG-ECIPRSWVCDGDPDCGDGSDEENC 37
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 981-1013 1.00e-03

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 39.53  E-value: 1.00e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 126012573   981 NGDCSHFCFPVPNfQRVCGCPYGMRLASNHLTC 1013
Cdd:pfam14670    5 NGGCSHLCLNTPG-GYTCSCPEGYELQDDGRTC 36
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 1787-1951 1.18e-03

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 44.11  E-value: 1.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012573 1787 DAEQYIYWVENP-GEIHRVKTDGTNRTVFASISmvGPSMNLALD-----WI---SRNLYSTNPRTQSIEVLTLHGDIRYR 1857
Cdd:COG3386    16 DPDGRLYWVDIPgGRIHRYDPDGGAVEVFAEPS--GRPNGLAFDpdgrlLVadhGRGLVRFDPADGEVTVLADEYGKPLN 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012573 1858 ktlIANDGtalgvgfpigiTVDPArGKLYWSDQGTDSGvPAKIASANMDGtSVKTLFTG----N-LehleCVTLDieEQK 1932
Cdd:COG3386    94 ---RPNDG-----------VVDPD-GRLYFTDMGEYLP-TGALYRVDPDG-SLRVLADGltfpNgI----AFSPD--GRT 150

                         170
                  ....*....|....*....
gi 126012573 1933 LYWAVTGRGVIERGNVDGT 1951
Cdd:COG3386   151 LYVADTGAGRIYRFDLDAD 169
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 2470-2575 1.40e-03

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 43.85  E-value: 1.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012573 2470 GIAFDwITRRIYYSDYLNQMI-------NSMAEDGSNRTVIARVPKPRAIVLDPcQGYLYWADWDTHA----KIERATLG 2538
Cdd:cd05819   153 GVAVD-SDGNIYVADTGNHRIqvfdpdgNFLTTFGSTGTGPGQFNYPTGIAVDS-DGNIYVADSGNNRvqvfDPDGAGFG 230

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 126012573 2539 GNFRVPIVNSSLVMPSGLTLDyEEDLLYWVDASLQRI 2575
Cdd:cd05819   231 GNGNFLGSDGQFNRPSGLAVD-SDGNLYVADTGNNRI 266
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 2655-2692 1.40e-03

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 39.15  E-value: 1.40e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 126012573  2655 CEQFNGGCSHICAPGPNGAECQCPHEgnWYLANNRKHC 2692
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEG--YELQDDGRTC 36
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
2417-2624 1.55e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 43.53  E-value: 1.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012573 2417 VERTVMSLDYDSVSDRIYFTQNLASGVGQISYATLSSGIHTPTVIASGIGTADGIAFDWITRRIYYSDYLNQMINSMaeD 2496
Cdd:COG3391    19 AALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLYVANSGSGRVSVI--D 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012573 2497 GSNRTVIARVP---KPRAIVLDPCQGYLYWADWDTHA--KIERATLGGNFRVPIVNSslvmPSGLTLDYEEDLLYWVDAS 2571
Cdd:COG3391    97 LATGKVVATIPvggGPRGLAVDPDGGRLYVADSGNGRvsVIDTATGKVVATIPVGAG----PHGIAVDPDGKRLYVANSG 172

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 126012573 2572 -------LQRIERSTLTGVDReviVNAAVHAFGLTLY--GQYIYWTDLYTQriyRANKYDGS 2624
Cdd:COG3391   173 sntvsviVSVIDTATGKVVAT---IPVGGGPVGVAVSpdGRRLYVANRGSN---TSNGGSNT 228
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 3319-3432 1.78e-03

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 43.46  E-value: 1.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012573 3319 CFDNPRGLALHPQyGYLYWAD-WGHR--------AYIGRVGMDGTNksviiSTKLEWPNGITIDYTNDlLYWADAHLGYI 3389
Cdd:cd05819     6 ELNNPQGIAVDSS-GNIYVADtGNNRiqvfdpdgNFITSFGSFGSG-----DGQFNEPAGVAVDSDGN-LYVADTGNHRI 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 126012573 3390 EYSDLEGHHRHTV-----YDGALPHPFAITI-FEDTIYWTDWNTRTVEK 3432
Cdd:cd05819    79 QKFDPDGNFLASFggsgdGDGEFNGPRGIAVdSSGNIYVADTGNHRIQK 127
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 663-704 1.96e-03

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 38.76  E-value: 1.96e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 126012573   663 CKDNNGGCEQVCVlshrtdNDGLGFRCKCTFGFQLDTDERHC 704
Cdd:pfam14670    1 CSVNNGGCSHLCL------NTPGGYTCSCPEGYELQDDGRTC 36
EGF_CA pfam07645
Calcium-binding EGF domain;
4007-4035 2.20e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 38.37  E-value: 2.20e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 126012573  4007 DINECEQFGT-CPQ--HCRNTKGSYECVCADG 4035
Cdd:pfam07645    1 DVDECATGTHnCPAntVCVNTIGSFECRCPDG 32
EGF_CA pfam07645
Calcium-binding EGF domain;
3152-3181 2.65e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.99  E-value: 2.65e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 126012573  3152 DIDECTEMPFVCSQ--KCENVIGSYICKCAPG 3181
Cdd:pfam07645    1 DVDECATGTHNCPAntVCVNTIGSFECRCPDG 32
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 4141-4248 2.83e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 43.05  E-value: 2.83e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012573 4141 VMQPDGIAVDWVGRhIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQ-----PAAIAVNPKLGLM-----------FWTDw 4204
Cdd:cd14963   147 LSYPNGIAVDEDGN-IYVADSGNGRIQVFDKNGKFIKELNGSPDGKsgfvnPRGIAVDPDGNLYvvdnlshrvyvFDEQ- 224

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 126012573 4205 GKEpkIESAWMNGEDRNILVFedlgwPTGLSIDylNNDRIYWSD 4248
Cdd:cd14963   225 GKE--LFTFGGRGKDDGQFNL-----PNGLFID--DDGRLYVTD 259
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1461-1500 2.99e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 38.35  E-value: 2.99e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 126012573   1461 LVENGSYIVAVDFDSISGRIFWSDATQGKTWSAFQNGTDR 1500
Cdd:smart00135    4 LSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 415-457 3.20e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 38.35  E-value: 3.20e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 126012573    415 RILVeSQNRGVAVGVAFHYHLQRVFWTDTVQNKVFSVDINGLN 457
Cdd:smart00135    1 RTLL-SSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 3163-3191 3.33e-03

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 37.99  E-value: 3.33e-03
                           10        20
                   ....*....|....*....|....*....
gi 126012573  3163 CSQKCENVIGSYICKCAPGYLREPDGKTC 3191
Cdd:pfam14670    8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 469-650 3.37e-03

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 42.69  E-value: 3.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012573  469 PENLAVDwVNNKIYLVETKVNRIDMVNLDGSYRVTLIT-----ENLGHPRGIAVDPTvGYLFFSDWE-------SLSGEp 536
Cdd:cd05819    57 PAGVAVD-SDGNLYVADTGNHRIQKFDPDGNFLASFGGsgdgdGEFNGPRGIAVDSS-GNIYVADTGnhriqkfDPDGE- 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012573  537 kLERAFmdGSNrkDLVKTKLGWPAGVTLDmISKRVYWVDS------RFDYI-ETVTYDGiqrKTVVHGGSLIpHPFGVSL 609
Cdd:cd05819   134 -FLTTF--GSG--GSGPGQFNGPTGVAVD-SDGNIYVADTgnhriqVFDPDgNFLTTFG---STGTGPGQFN-YPTGIAV 203

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 126012573  610 F-EGQVFFTDWTKMAVLKANKFTETNPQVYYQASL-----RPYGVTV 650
Cdd:cd05819   204 DsDGNIYVADSGNNRVQVFDPDGAGFGGNGNFLGSdgqfnRPSGLAV 250
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 3294-3428 3.65e-03

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 42.69  E-value: 3.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012573 3294 LFVSDlNGGHRrmlaQHCVDANNTF------------CFDNPRGLALHPQyGYLYWADWG-HR--------AYIGRVGMD 3352
Cdd:cd05819   115 IYVAD-TGNHR----IQKFDPDGEFlttfgsggsgpgQFNGPTGVAVDSD-GNIYVADTGnHRiqvfdpdgNFLTTFGST 188

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012573 3353 GTNKSviistKLEWPNGITIDYtNDLLYWADAHLGYIEYSDLEGHHRHTVYDGALPH-----PFAITIFED-TIYWTD-W 3425
Cdd:cd05819   189 GTGPG-----QFNYPTGIAVDS-DGNIYVADSGNNRVQVFDPDGAGFGGNGNFLGSDgqfnrPSGLAVDSDgNLYVADtG 262


                  ...
gi 126012573 3426 NTR 3428
Cdd:cd05819   263 NNR 265
EGF_CA smart00179
Calcium-binding EGF-like domain;
3111-3151 3.88e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 3.88e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 126012573   3111 INECHDPSISGCDHNCTDTLTSFYCSCRPGYklmSDKRTCV 3151
Cdd:smart00179    2 IDECASGNPCQNGGTCVNTVGSYRCECPPGY---TDGRNCE 39
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 2137-2181 4.18e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 37.97  E-value: 4.18e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 126012573   2137 IVTHGIGEngVRGIAVDWVAGNLYFTNAfvSETLIEVLRINTTYR 2181
Cdd:smart00135    3 LLSSGLGH--PNGLAVDWIEGRLYWTDW--GLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 2593-2625 5.90e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 37.58  E-value: 5.90e-03
                            10        20        30
                    ....*....|....*....|....*....|...
gi 126012573   2593 VHAFGLTLYGQYIYWTDLYTQRIYRANkYDGSG 2625
Cdd:smart00135   11 PNGLAVDWIEGRLYWTDWGLDVIEVAN-LDGTN 42
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 4137-4303 6.03e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 41.89  E-value: 6.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012573 4137 KLKYvmqPDGIAVDWVGRhIYWSDVKNKRIEVAKLDGRYRKWLISTD----LDQPAAIAVnpKLGLMFWTDWGKEpKIES 4212
Cdd:cd14963    54 EFKY---PYGIAVDSDGN-IYVADLYNGRIQVFDPDGKFLKYFPEKKdrvkLISPAGLAI--DDGKLYVSDVKKH-KVIV 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012573 4213 AWMNGEdrNILVF-------EDLGWPTGLSID-----YL---NNDRIYWSDFKEDVIETIKYDGTD-------RRVIAKE 4270
Cdd:cd14963   127 FDLEGK--LLLEFgkpgsepGELSYPNGIAVDedgniYVadsGNGRIQVFDKNGKFIKELNGSPDGksgfvnpRGIAVDP 204

                         170       180       190
                  ....*....|....*....|....*....|...
gi 126012573 4271 AMNPYSLDIFEDQLYWISKEKGEVWKQNKFGQG 4303
Cdd:cd14963   205 DGNLYVVDNLSHRVYVFDEQGKELFTFGGRGKD 237
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 4338-4356 6.96e-03

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 37.22  E-value: 6.96e-03
                           10
                   ....*....|....*....
gi 126012573  4338 CSHLCLLRPGGYSCACPQG 4356
Cdd:pfam14670    8 CSHLCLNTPGGYTCSCPEG 26
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 4143-4260 7.49e-03

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 41.54  E-value: 7.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012573 4143 QPDGIAVDWVGrHIYWSDVKNKRIEVAKLDGRYrKWLISTD------LDQPAAIAVNPKlGLMFWTD--------WGKEP 4208
Cdd:cd05819     9 NPQGIAVDSSG-NIYVADTGNNRIQVFDPDGNF-ITSFGSFgsgdgqFNEPAGVAVDSD-GNLYVADtgnhriqkFDPDG 85

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 126012573 4209 KIESAW-MNGEDrnilvFEDLGWPTGLSIDylNNDRIYWSDFKEDVIetIKYD 4260
Cdd:cd05819    86 NFLASFgGSGDG-----DGEFNGPRGIAVD--SSGNIYVADTGNHRI--QKFD 129
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1811-1855 7.85e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 37.20  E-value: 7.85e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 126012573   1811 RTVFASisMVGPSMNLALDWISRNLYSTNPRTQSIEVLTLHGDIR 1855
Cdd:smart00135    1 RTLLSS--GLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 436-476 8.05e-03

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 37.14  E-value: 8.05e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 126012573   436 QRVFWTDTVQ-NKVFSVDINGLNIQEVLNVSVETPENLAVDW 476
Cdd:pfam00058    1 GRLYWTDSSLrASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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