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Conserved domains on  [gi|31563388|ref|NP_004596|]
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sulfotransferase 2B1 isoform a [Homo sapiens]

Protein Classification

sulfotransferase domain-containing protein( domain architecture ID 10464534)

sulfotransferase domain-containing protein such as mammalian sulfotransferases that utilize 3'-phospho-5'-adenylyl sulfate (PAPS) as the sulfonate donor to catalyze the sulfate conjugation of a variety of substrates including catecholamines, phenolic drugs, neurotransmitters, heparan, and estrogen, among others

CATH:  3.40.50.300
EC:  2.8.2.-
Gene Ontology:  GO:0008146
PubMed:  9360604|31270211
SCOP:  4003933

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
45-290 1.34e-100

Sulfotransferase domain;


:

Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 297.33  E-value: 1.34e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563388    45 DDDIFIITYPKSGTTWMIEIICLILKEGDPSWIRSVPI---WERAPWCETIVGAFS---------LPDQYSPRLMSSHLP 112
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKSEEPHLfnnHNRSPFLEWYPGDTYfdvaegpvrLNALPSPRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563388   113 IQIFTKAFFSSKAKVIYMGRNPRDVVVSLYHYSKIAGQLKDPGTPDQFLRDFLKGEVQFGSWFDHIKGWLRMKGKDNFLF 192
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563388   193 ITYEELQQDLQGSVERICGFLGRPLGKEALGSVVAHSTFSAMKANTMSNYTLLPPSLldhrrGAFLRKGVCGDWKNHFTV 272
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLPKEV-----SPFFRKGLVGDWKNYFTP 235

                         250
                  ....*....|....*...
gi 31563388   273 AQSEAFDRAYRKQMRGMP 290
Cdd:pfam00685 236 EQAEKFDEIYQEKMKGTG 253
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
45-290 1.34e-100

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 297.33  E-value: 1.34e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563388    45 DDDIFIITYPKSGTTWMIEIICLILKEGDPSWIRSVPI---WERAPWCETIVGAFS---------LPDQYSPRLMSSHLP 112
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKSEEPHLfnnHNRSPFLEWYPGDTYfdvaegpvrLNALPSPRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563388   113 IQIFTKAFFSSKAKVIYMGRNPRDVVVSLYHYSKIAGQLKDPGTPDQFLRDFLKGEVQFGSWFDHIKGWLRMKGKDNFLF 192
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563388   193 ITYEELQQDLQGSVERICGFLGRPLGKEALGSVVAHSTFSAMKANTMSNYTLLPPSLldhrrGAFLRKGVCGDWKNHFTV 272
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLPKEV-----SPFFRKGLVGDWKNYFTP 235

                         250
                  ....*....|....*...
gi 31563388   273 AQSEAFDRAYRKQMRGMP 290
Cdd:pfam00685 236 EQAEKFDEIYQEKMKGTG 253
PLN02164 PLN02164
sulfotransferase
 31-271 3.89e-16

sulfotransferase


Pssm-ID: 177822  Cd Length: 346  Bit Score: 78.42  E-value: 3.89e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563388   31 LESISLAENTQDVRDDDIFIITYPKSGTTWMIEIICLILKEG--DPSwirSVPIWER-----APWCETIVGAFS----LP 99
Cdd:PLN02164  65 LEGLLHAQEFFQARPNDFLVCSYPKTGTTWLKALTFAIANRSrfDDS---SNPLLKRnphefVPYIEIDFPFFPsvdvLK 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563388  100 DQYSPrLMSSHLPIQIFTKAFFSSKAKVIYMGRNPRDVVVSLYHY-SKIAGQLKDPGTPDQFLRDFLKGEVQFGSWFDHI 178
Cdd:PLN02164 142 DKGNT-LFSTHIPYGLLPDSVVKSGCKMVYIWRDPKDTFISMWTFlHKERSQQGPLNSLEESFDMFCRGLSVYGPYLDHV 220

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563388  179 KGWLR--MKGKDNFLFITYEELQQDLQGSVERICGFLGRPLGKE-----ALGSVVAHSTFSAMK---ANTMSNYTLLPPS 248
Cdd:PLN02164 221 LGYWKayQENPDRILFLKYETMRADPLPYVKRLAEFMGYGFTAEeeekgVVEKVVKLCSFETLKnleANKGEKDREDRPA 300

                        250       260
                 ....*....|....*....|...
gi 31563388  249 LldHRRGAFLRKGVCGDWKNHFT 271
Cdd:PLN02164 301 V--YANSAYFRKGKVGDWQNYLT 321
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
45-290 1.34e-100

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 297.33  E-value: 1.34e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563388    45 DDDIFIITYPKSGTTWMIEIICLILKEGDPSWIRSVPI---WERAPWCETIVGAFS---------LPDQYSPRLMSSHLP 112
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKSEEPHLfnnHNRSPFLEWYPGDTYfdvaegpvrLNALPSPRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563388   113 IQIFTKAFFSSKAKVIYMGRNPRDVVVSLYHYSKIAGQLKDPGTPDQFLRDFLKGEVQFGSWFDHIKGWLRMKGKDNFLF 192
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563388   193 ITYEELQQDLQGSVERICGFLGRPLGKEALGSVVAHSTFSAMKANTMSNYTLLPPSLldhrrGAFLRKGVCGDWKNHFTV 272
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLPKEV-----SPFFRKGLVGDWKNYFTP 235

                         250
                  ....*....|....*...
gi 31563388   273 AQSEAFDRAYRKQMRGMP 290
Cdd:pfam00685 236 EQAEKFDEIYQEKMKGTG 253
PLN02164 PLN02164
sulfotransferase
 31-271 3.89e-16

sulfotransferase


Pssm-ID: 177822  Cd Length: 346  Bit Score: 78.42  E-value: 3.89e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563388   31 LESISLAENTQDVRDDDIFIITYPKSGTTWMIEIICLILKEG--DPSwirSVPIWER-----APWCETIVGAFS----LP 99
Cdd:PLN02164  65 LEGLLHAQEFFQARPNDFLVCSYPKTGTTWLKALTFAIANRSrfDDS---SNPLLKRnphefVPYIEIDFPFFPsvdvLK 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563388  100 DQYSPrLMSSHLPIQIFTKAFFSSKAKVIYMGRNPRDVVVSLYHY-SKIAGQLKDPGTPDQFLRDFLKGEVQFGSWFDHI 178
Cdd:PLN02164 142 DKGNT-LFSTHIPYGLLPDSVVKSGCKMVYIWRDPKDTFISMWTFlHKERSQQGPLNSLEESFDMFCRGLSVYGPYLDHV 220

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563388  179 KGWLR--MKGKDNFLFITYEELQQDLQGSVERICGFLGRPLGKE-----ALGSVVAHSTFSAMK---ANTMSNYTLLPPS 248
Cdd:PLN02164 221 LGYWKayQENPDRILFLKYETMRADPLPYVKRLAEFMGYGFTAEeeekgVVEKVVKLCSFETLKnleANKGEKDREDRPA 300

                        250       260
                 ....*....|....*....|...
gi 31563388  249 LldHRRGAFLRKGVCGDWKNHFT 271
Cdd:PLN02164 301 V--YANSAYFRKGKVGDWQNYLT 321
Sulfotransfer_3 pfam13469
Sulfotransferase family;
48-217 4.89e-11

Sulfotransferase family;


Pssm-ID: 463887  Cd Length: 173  Bit Score: 60.77  E-value: 4.89e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563388    48 IFIITYPKSGTTWMIEIIClilkeGDPSwIRSVPIWER-APWCETIVGAFSLP-------DQYSPRL---MSSHLPiQI- 115
Cdd:pfam13469   1 IFIVGLPRSGTTLLHRLLA-----AHPD-VRPPEETWFvIPRILALLQAWGKSlealarvPSYARWLcdkSPSHLF-HLd 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563388   116 FTKAFFSsKAKVIYMGRNPRDVVVSLY-HYSKIAGQLKDPGTPDQFLRDFLKgevqfgsWFDHIKGWLRMK---GKDNFL 191
Cdd:pfam13469  74 LLLKAFP-DAKFIHLHRDPVDTVISSYcSLFGFTLSSYSTAFLRDIGLALAR-------WSRAYERLMAARarvPPGRFL 145

                         170       180
                  ....*....|....*....|....*.
gi 31563388   192 FITYEELQQDLQGSVERICGFLGRPL 217
Cdd:pfam13469 146 DVRYEDLVADPEGTLRRILEFLGLPW 171
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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