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Conserved domains on  [gi|4826651|ref|NP_004919|]
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nuclear encoded mitochondrial protein C21orf2 isoform 1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 40-130 2.40e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 58.64  E-value: 2.40e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4826651   40 PSLEVITLSVNSISTLEPVSRCQRLSELYLRRNRIPSLAELF-YLKGLPRLRVLWLAENPCCgtSPHRYRMTVLRTLPRL 118
Cdd:cd21340 120 NSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLdLLSSWPSLRELDLTGNPVC--KKPKYRDKIILASKSL 197

                        90
                ....*....|..
gi 4826651  119 QKLDNQAVTEEE 130
Cdd:cd21340 198 EVLDGKEITDTE 209
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 19-59 5.50e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


:

Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.14  E-value: 5.50e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 4826651     19 SVRKLNCWGSRLTDISICQEMPSLEVITLSVNS-ISTLEPVS 59
Cdd:pfam12799   2 NLEVLDLSNNQITDIPPLAKLPNLETLDLSGNNkITDLSDLA 43
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 40-130 2.40e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 58.64  E-value: 2.40e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4826651   40 PSLEVITLSVNSISTLEPVSRCQRLSELYLRRNRIPSLAELF-YLKGLPRLRVLWLAENPCCgtSPHRYRMTVLRTLPRL 118
Cdd:cd21340 120 NSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLdLLSSWPSLRELDLTGNPVC--KKPKYRDKIILASKSL 197

                        90
                ....*....|..
gi 4826651  119 QKLDNQAVTEEE 130
Cdd:cd21340 198 EVLDGKEITDTE 209
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
15-122 4.82e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 59.18  E-value: 4.82e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4826651   15 SELHSVRKLNCWGSRLTDI-SICQEMPSLEVITLSVNSISTL-EPVSRCQRLSELYLRRNRIPSLAElfYLKGLPRLRVL 92
Cdd:COG4886 133 ANLTNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNNQITDLPE--PLGNLTNLEEL 210

                        90       100       110
                ....*....|....*....|....*....|....
gi 4826651   93 WLAENpccgtsphryRMT----VLRTLPRLQKLD 122
Cdd:COG4886 211 DLSGN----------QLTdlpePLANLTNLETLD 234
LRR_8 pfam13855
Leucine rich repeat;
19-74 2.25e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.27  E-value: 2.25e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4826651     19 SVRKLNCWGSRLTdiSICQE----MPSLEVITLSVNSISTLEPVS--RCQRLSELYLRRNRI 74
Cdd:pfam13855   2 NLRSLDLSNNRLT--SLDDGafkgLSNLKVLDLSNNLLTTLSPGAfsGLPSLRYLDLSGNRL 61
LRRcap smart00446
occurring C-terminal to leucine-rich repeats; A motif occurring C-terminal to leucine-rich ...
 104-122 1.43e-03

occurring C-terminal to leucine-rich repeats; A motif occurring C-terminal to leucine-rich repeats in "sds22-like" and "typical" LRR-containing proteins.


Pssm-ID: 197729  Cd Length: 19  Bit Score: 34.98  E-value: 1.43e-03
                           10
                   ....*....|....*....
gi 4826651     104 PHRYRMTVLRTLPRLQKLD 122
Cdd:smart00446   1 LAHYREKVIELLPQLRKLD 19
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 19-59 5.50e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.14  E-value: 5.50e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 4826651     19 SVRKLNCWGSRLTDISICQEMPSLEVITLSVNS-ISTLEPVS 59
Cdd:pfam12799   2 NLEVLDLSNNQITDIPPLAKLPNLETLDLSGNNkITDLSDLA 43
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 38-104 9.94e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 37.13  E-value: 9.94e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4826651    38 EMPSLEVITLSVNSIS-TLEPVSRCQRLSELYLRRNRIPSLAELfYLKGLPRLRVLWLAENPCCGTSP 104
Cdd:PLN00113 450 DMPSLQMLSLARNKFFgGLPDSFGSKRLENLDLSRNQFSGAVPR-KLGSLSELMQLKLSENKLSGEIP 516
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 40-130 2.40e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 58.64  E-value: 2.40e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4826651   40 PSLEVITLSVNSISTLEPVSRCQRLSELYLRRNRIPSLAELF-YLKGLPRLRVLWLAENPCCgtSPHRYRMTVLRTLPRL 118
Cdd:cd21340 120 NSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLdLLSSWPSLRELDLTGNPVC--KKPKYRDKIILASKSL 197

                        90
                ....*....|..
gi 4826651  119 QKLDNQAVTEEE 130
Cdd:cd21340 198 EVLDGKEITDTE 209
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
15-122 4.82e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 59.18  E-value: 4.82e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4826651   15 SELHSVRKLNCWGSRLTDI-SICQEMPSLEVITLSVNSISTL-EPVSRCQRLSELYLRRNRIPSLAElfYLKGLPRLRVL 92
Cdd:COG4886 133 ANLTNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNNQITDLPE--PLGNLTNLEEL 210

                        90       100       110
                ....*....|....*....|....*....|....
gi 4826651   93 WLAENpccgtsphryRMT----VLRTLPRLQKLD 122
Cdd:COG4886 211 DLSGN----------QLTdlpePLANLTNLETLD 234
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
15-98 5.84e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 56.10  E-value: 5.84e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4826651   15 SELHSVRKLNCWGSRLTDISIC-QEMPSLEVITLSVNSISTLEPVSRCQRLSELYLRRNRIPSLAElfyLKGLPRLRVLW 93
Cdd:COG4886 202 GNLTNLEELDLSGNQLTDLPEPlANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPP---LANLTNLKTLD 278


                ....*
gi 4826651   94 LAENP 98
Cdd:COG4886 279 LSNNQ 283
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
15-77 3.46e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 47.62  E-value: 3.46e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4826651   15 SELHSVRKLNCWGSRLTDISICQEMPSLEVITLSVNSISTLEPVSRCQRLSELYLRRNRIPSL 77
Cdd:COG4886 225 ANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDL 287
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 17-130 1.26e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 44.78  E-value: 1.26e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4826651   17 LHSVRKLNCWGSRLTDISICQEMPSLEVITLSVNSISTLEPVSRCQRLSELYLRRNRIPSLAelfYLKGLPRLRVLWLAE 96
Cdd:cd21340   1 LKRITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIE---NLENLVNLKKLYLGG 77

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 4826651   97 NpccgtsphryRMTV---LRTLPRLQ--KLDNQAVTEEE 130
Cdd:cd21340  78 N----------RISVvegLENLTNLEelHIENQRLPPGE 106
LRR_8 pfam13855
Leucine rich repeat;
19-74 2.25e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.27  E-value: 2.25e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4826651     19 SVRKLNCWGSRLTdiSICQE----MPSLEVITLSVNSISTLEPVS--RCQRLSELYLRRNRI 74
Cdd:pfam13855   2 NLRSLDLSNNRLT--SLDDGafkgLSNLKVLDLSNNLLTTLSPGAfsGLPSLRYLDLSGNRL 61
LRR_9 pfam14580
Leucine-rich repeat;
64-134 2.90e-04

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 40.52  E-value: 2.90e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4826651     64 LSELYLRRNRIPSLAELFYLKGLPRLRVLWLAENPCCgTSPHrYRMTVLRTLPRLQKLDNQAVTEEELSRA 134
Cdd:pfam14580  90 LTELILTNNNLQELGDLDPLASLKKLTFLSLLRNPVT-NKPH-YRLYVIYKVPQLRLLDFRKVKQKERQAA 158
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 40-80 8.35e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.45  E-value: 8.35e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 4826651     40 PSLEVITLSVNSISTLEPVSRCQRLSELYLRRN-RIPSLAEL 80
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGNnKITDLSDL 42
LRRcap smart00446
occurring C-terminal to leucine-rich repeats; A motif occurring C-terminal to leucine-rich ...
 104-122 1.43e-03

occurring C-terminal to leucine-rich repeats; A motif occurring C-terminal to leucine-rich repeats in "sds22-like" and "typical" LRR-containing proteins.


Pssm-ID: 197729  Cd Length: 19  Bit Score: 34.98  E-value: 1.43e-03
                           10
                   ....*....|....*....
gi 4826651     104 PHRYRMTVLRTLPRLQKLD 122
Cdd:smart00446   1 LAHYREKVIELLPQLRKLD 19
LRR_8 pfam13855
Leucine rich repeat;
40-98 3.82e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 34.81  E-value: 3.82e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4826651     40 PSLEVITLSVNSISTLEPVS--RCQRLSELYLRRNRIPSL-AELFYlkGLPRLRVLWLAENP 98
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAfkGLSNLKVLDLSNNLLTTLsPGAFS--GLPSLRYLDLSGNR 60
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 19-59 5.50e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.14  E-value: 5.50e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 4826651     19 SVRKLNCWGSRLTDISICQEMPSLEVITLSVNS-ISTLEPVS 59
Cdd:pfam12799   2 NLEVLDLSNNQITDIPPLAKLPNLETLDLSGNNkITDLSDLA 43
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 62-98 7.69e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 33.76  E-value: 7.69e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 4826651     62 QRLSELYLRRNRIPSLAELfylKGLPRLRVLWLAENP 98
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPL---AKLPNLETLDLSGNN 34
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 38-104 9.94e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 37.13  E-value: 9.94e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4826651    38 EMPSLEVITLSVNSIS-TLEPVSRCQRLSELYLRRNRIPSLAELfYLKGLPRLRVLWLAENPCCGTSP 104
Cdd:PLN00113 450 DMPSLQMLSLARNKFFgGLPDSFGSKRLENLDLSRNQFSGAVPR-KLGSLSELMQLKLSENKLSGEIP 516
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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