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Conserved domains on  [gi|12056461|ref|NP_005199|]
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beta-crystallin A3 [Homo sapiens]

Protein Classification

beta/gamma crystallin family protein( domain architecture ID 10440390)

beta/gamma crystallin family protein such as beta- and gamma-crystallins, which are structural components of the vertebrate eye lens

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Crystall pfam00030
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ...
125-213 9.89e-37

Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.


:

Pssm-ID: 459639  Cd Length: 82  Bit Score: 123.37  E-value: 9.89e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12056461   125 KMTIFEKENFIGRQWEISDDYPSLQAMGwFNNEVGSMKIQSGAWVCYQYPGYRGYQYILEcdhhGGDYKHWREWGshAQT 204
Cdd:pfam00030   1 KIVLYEKENFQGRSIELTDDCPSLQERG-FNSRVNSIRVLSGAWVLYEHPNFRGRQYVLE----PGEYPDWSDWG--APN 73

                  ....*....
gi 12056461   205 SQIQSIRRI 213
Cdd:pfam00030  74 DRIGSLRPI 82
Crystall pfam00030
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ...
32-116 1.86e-36

Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.


:

Pssm-ID: 459639  Cd Length: 82  Bit Score: 122.60  E-value: 1.86e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12056461    32 KITIYDQENFQGKRMEFTSSCPNVSERSF-DNVRSLKVESGAWIGYEHTSFCGQQFILERGEYPRWDAWSGSNAyhieRL 110
Cdd:pfam00030   1 KIVLYEKENFQGRSIELTDDCPSLQERGFnSRVNSIRVLSGAWVLYEHPNFRGRQYVLEPGEYPDWSDWGAPND----RI 76

                  ....*.
gi 12056461   111 MSFRPI 116
Cdd:pfam00030  77 GSLRPI 82
 
Name Accession Description Interval E-value
Crystall pfam00030
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ...
125-213 9.89e-37

Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.


Pssm-ID: 459639  Cd Length: 82  Bit Score: 123.37  E-value: 9.89e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12056461   125 KMTIFEKENFIGRQWEISDDYPSLQAMGwFNNEVGSMKIQSGAWVCYQYPGYRGYQYILEcdhhGGDYKHWREWGshAQT 204
Cdd:pfam00030   1 KIVLYEKENFQGRSIELTDDCPSLQERG-FNSRVNSIRVLSGAWVLYEHPNFRGRQYVLE----PGEYPDWSDWG--APN 73

                  ....*....
gi 12056461   205 SQIQSIRRI 213
Cdd:pfam00030  74 DRIGSLRPI 82
Crystall pfam00030
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ...
32-116 1.86e-36

Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.


Pssm-ID: 459639  Cd Length: 82  Bit Score: 122.60  E-value: 1.86e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12056461    32 KITIYDQENFQGKRMEFTSSCPNVSERSF-DNVRSLKVESGAWIGYEHTSFCGQQFILERGEYPRWDAWSGSNAyhieRL 110
Cdd:pfam00030   1 KIVLYEKENFQGRSIELTDDCPSLQERGFnSRVNSIRVLSGAWVLYEHPNFRGRQYVLEPGEYPDWSDWGAPND----RI 76

                  ....*.
gi 12056461   111 MSFRPI 116
Cdd:pfam00030  77 GSLRPI 82
XTALbg smart00247
Beta/gamma crystallins; Beta/gamma crystallins
125-213 2.49e-36

Beta/gamma crystallins; Beta/gamma crystallins


Pssm-ID: 214583  Cd Length: 82  Bit Score: 122.23  E-value: 2.49e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12056461    125 KMTIFEKENFIGRQWEISDDYPSLQAMGWFNNeVGSMKIQSGAWVCYQYPGYRGYQYILECdhhgGDYKHWREWGshAQT 204
Cdd:smart00247   1 KITLYEDENFQGRSYELSDDCPSLQDYGSRDN-VSSVRVESGCWVLYEQPNYRGRQYVLEP----GEYPDYQEWG--GFN 73

                   ....*....
gi 12056461    205 SQIQSIRRI 213
Cdd:smart00247  74 DQISSIRRI 82
XTALbg smart00247
Beta/gamma crystallins; Beta/gamma crystallins
32-116 2.02e-35

Beta/gamma crystallins; Beta/gamma crystallins


Pssm-ID: 214583  Cd Length: 82  Bit Score: 119.92  E-value: 2.02e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12056461     32 KITIYDQENFQGKRMEFTSSCPNVSER-SFDNVRSLKVESGAWIGYEHTSFCGQQFILERGEYPRWDAWSGSNAyhieRL 110
Cdd:smart00247   1 KITLYEDENFQGRSYELSDDCPSLQDYgSRDNVSSVRVESGCWVLYEQPNYRGRQYVLEPGEYPDYQEWGGFND----QI 76

                   ....*.
gi 12056461    111 MSFRPI 116
Cdd:smart00247  77 SSIRRI 82
 
Name Accession Description Interval E-value
Crystall pfam00030
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ...
125-213 9.89e-37

Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.


Pssm-ID: 459639  Cd Length: 82  Bit Score: 123.37  E-value: 9.89e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12056461   125 KMTIFEKENFIGRQWEISDDYPSLQAMGwFNNEVGSMKIQSGAWVCYQYPGYRGYQYILEcdhhGGDYKHWREWGshAQT 204
Cdd:pfam00030   1 KIVLYEKENFQGRSIELTDDCPSLQERG-FNSRVNSIRVLSGAWVLYEHPNFRGRQYVLE----PGEYPDWSDWG--APN 73

                  ....*....
gi 12056461   205 SQIQSIRRI 213
Cdd:pfam00030  74 DRIGSLRPI 82
Crystall pfam00030
Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity ...
32-116 1.86e-36

Beta/Gamma crystallin; The alignment comprises two Greek key motifs since the similarity between them is very low.


Pssm-ID: 459639  Cd Length: 82  Bit Score: 122.60  E-value: 1.86e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12056461    32 KITIYDQENFQGKRMEFTSSCPNVSERSF-DNVRSLKVESGAWIGYEHTSFCGQQFILERGEYPRWDAWSGSNAyhieRL 110
Cdd:pfam00030   1 KIVLYEKENFQGRSIELTDDCPSLQERGFnSRVNSIRVLSGAWVLYEHPNFRGRQYVLEPGEYPDWSDWGAPND----RI 76

                  ....*.
gi 12056461   111 MSFRPI 116
Cdd:pfam00030  77 GSLRPI 82
XTALbg smart00247
Beta/gamma crystallins; Beta/gamma crystallins
125-213 2.49e-36

Beta/gamma crystallins; Beta/gamma crystallins


Pssm-ID: 214583  Cd Length: 82  Bit Score: 122.23  E-value: 2.49e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12056461    125 KMTIFEKENFIGRQWEISDDYPSLQAMGWFNNeVGSMKIQSGAWVCYQYPGYRGYQYILECdhhgGDYKHWREWGshAQT 204
Cdd:smart00247   1 KITLYEDENFQGRSYELSDDCPSLQDYGSRDN-VSSVRVESGCWVLYEQPNYRGRQYVLEP----GEYPDYQEWG--GFN 73

                   ....*....
gi 12056461    205 SQIQSIRRI 213
Cdd:smart00247  74 DQISSIRRI 82
XTALbg smart00247
Beta/gamma crystallins; Beta/gamma crystallins
32-116 2.02e-35

Beta/gamma crystallins; Beta/gamma crystallins


Pssm-ID: 214583  Cd Length: 82  Bit Score: 119.92  E-value: 2.02e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12056461     32 KITIYDQENFQGKRMEFTSSCPNVSER-SFDNVRSLKVESGAWIGYEHTSFCGQQFILERGEYPRWDAWSGSNAyhieRL 110
Cdd:smart00247   1 KITLYEDENFQGRSYELSDDCPSLQDYgSRDNVSSVRVESGCWVLYEQPNYRGRQYVLEPGEYPDYQEWGGFND----QI 76

                   ....*.
gi 12056461    111 MSFRPI 116
Cdd:smart00247  77 SSIRRI 82
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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