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Conserved domains on  [gi|54112432|ref|NP_005253|]
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FAD-linked sulfhydryl oxidase ALR [Homo sapiens]

Protein Classification

Erv1/Alr family FAD-linked sulfhydryl oxidase( domain architecture ID 6790)

Erv1/Alr family FAD-linked sulfhydryl oxidase catalyzes disulfide bond formation, similar to Homo sapiens FAD-linked sulfhydryl oxidase ALR and Arabidopsis thaliana FAD-linked sulfhydryl oxidase ERV1

CATH:  1.20.120.310
EC:  1.8.3.2
Gene Ontology:  GO:0016972|GO:0050660|GO:0016971
SCOP:  4002787

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Evr1_Alr super family cl02107
Erv1 / Alr family; Biogenesis of Fe/S clusters involves a number of essential mitochondrial ...
 86-201 2.14e-48

Erv1 / Alr family; Biogenesis of Fe/S clusters involves a number of essential mitochondrial proteins. Erv1p of Saccharomyces cerevisiae mitochondria is required for the maturation of Fe/S proteins in the cytosol. The ALR (augmenter of liver regeneration) represents a mammalian orthologue of yeast Erv1p. Both Erv1p and full-length ALR are located in the mitochondrial intermembrane an d it thought to operate downstream of the mitochondrial ABC transporter.


The actual alignment was detected with superfamily member COG5054:

Pssm-ID: 470469  Cd Length: 181  Bit Score: 156.19  E-value: 2.14e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54112432  86 KRDTKFREDCPPDREELGRHSWAVLHTLAAYYPDLPTPEQQQDMAQFIHLFSKFYPCEECAEDLRKRLCRNHPDTRTRAC 165
Cdd:COG5054  66 PITMMSTKHDNPDVEELGRSSWTLLHTVAANYPARPTPQQRDDLRSFLFLFSITYPCGECSKHFQKLLDVYPPQVSSREA 145

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 54112432 166 FTQWLCHLHNEVNRKLGKPDFDCSKVDERWRDGWKD 201
Cdd:COG5054 146 ATTWACEVHNKVNEKLGKPKFDCDTWNERYDCGCDT 181
 
Name Accession Description Interval E-value
ERV1 COG5054
Mitochondrial sulfhydryl oxidase involved in the biogenesis of cytosolic Fe/S proteins ...
 86-201 2.14e-48

Mitochondrial sulfhydryl oxidase involved in the biogenesis of cytosolic Fe/S proteins [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227387  Cd Length: 181  Bit Score: 156.19  E-value: 2.14e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54112432  86 KRDTKFREDCPPDREELGRHSWAVLHTLAAYYPDLPTPEQQQDMAQFIHLFSKFYPCEECAEDLRKRLCRNHPDTRTRAC 165
Cdd:COG5054  66 PITMMSTKHDNPDVEELGRSSWTLLHTVAANYPARPTPQQRDDLRSFLFLFSITYPCGECSKHFQKLLDVYPPQVSSREA 145

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 54112432 166 FTQWLCHLHNEVNRKLGKPDFDCSKVDERWRDGWKD 201
Cdd:COG5054 146 ATTWACEVHNKVNEKLGKPKFDCDTWNERYDCGCDT 181
Evr1_Alr pfam04777
Erv1 / Alr family; Biogenesis of Fe/S clusters involves a number of essential mitochondrial ...
 104-196 7.58e-48

Erv1 / Alr family; Biogenesis of Fe/S clusters involves a number of essential mitochondrial proteins. Erv1p of Saccharomyces cerevisiae mitochondria is required for the maturation of Fe/S proteins in the cytosol. The ALR (augmenter of liver regeneration) represents a mammalian orthologue of yeast Erv1p. Both Erv1p and full-length ALR are located in the mitochondrial intermembrane an d it thought to operate downstream of the mitochondrial ABC transporter.


Pssm-ID: 461423  Cd Length: 93  Bit Score: 151.62  E-value: 7.58e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54112432   104 RHSWAVLHTLAAYYPDLPTPEQQQDMAQFIHLFSKFYPCEECAEDLRKRLCRNHPDTRTRACFTQWLCHLHNEVNRKLGK 183
Cdd:pfam04777   1 RSTWTLLHTLAAYYPEKPTEEQQKDMKAFLDLFSHFYPCGECAEHFQKYLAKNPPQVSSRDALSLWLCEAHNEVNERLGK 80

                          90
                  ....*....|...
gi 54112432   184 PDFDCSKVDERWR 196
Cdd:pfam04777  81 PEFDCSKVKERWP 93
 
Name Accession Description Interval E-value
ERV1 COG5054
Mitochondrial sulfhydryl oxidase involved in the biogenesis of cytosolic Fe/S proteins ...
 86-201 2.14e-48

Mitochondrial sulfhydryl oxidase involved in the biogenesis of cytosolic Fe/S proteins [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227387  Cd Length: 181  Bit Score: 156.19  E-value: 2.14e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54112432  86 KRDTKFREDCPPDREELGRHSWAVLHTLAAYYPDLPTPEQQQDMAQFIHLFSKFYPCEECAEDLRKRLCRNHPDTRTRAC 165
Cdd:COG5054  66 PITMMSTKHDNPDVEELGRSSWTLLHTVAANYPARPTPQQRDDLRSFLFLFSITYPCGECSKHFQKLLDVYPPQVSSREA 145

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 54112432 166 FTQWLCHLHNEVNRKLGKPDFDCSKVDERWRDGWKD 201
Cdd:COG5054 146 ATTWACEVHNKVNEKLGKPKFDCDTWNERYDCGCDT 181
Evr1_Alr pfam04777
Erv1 / Alr family; Biogenesis of Fe/S clusters involves a number of essential mitochondrial ...
 104-196 7.58e-48

Erv1 / Alr family; Biogenesis of Fe/S clusters involves a number of essential mitochondrial proteins. Erv1p of Saccharomyces cerevisiae mitochondria is required for the maturation of Fe/S proteins in the cytosol. The ALR (augmenter of liver regeneration) represents a mammalian orthologue of yeast Erv1p. Both Erv1p and full-length ALR are located in the mitochondrial intermembrane an d it thought to operate downstream of the mitochondrial ABC transporter.


Pssm-ID: 461423  Cd Length: 93  Bit Score: 151.62  E-value: 7.58e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54112432   104 RHSWAVLHTLAAYYPDLPTPEQQQDMAQFIHLFSKFYPCEECAEDLRKRLCRNHPDTRTRACFTQWLCHLHNEVNRKLGK 183
Cdd:pfam04777   1 RSTWTLLHTLAAYYPEKPTEEQQKDMKAFLDLFSHFYPCGECAEHFQKYLAKNPPQVSSRDALSLWLCEAHNEVNERLGK 80

                          90
                  ....*....|...
gi 54112432   184 PDFDCSKVDERWR 196
Cdd:pfam04777  81 PEFDCSKVKERWP 93
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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