NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|154146191|ref|NP_005339|]
View 

heat shock protein HSP 90-alpha isoform 2 [Homo sapiens]

Protein Classification

HSP90 family protein( domain architecture ID 1903338)

HSP90 (heat shock protein 90) family protein functions as a molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved in cell cycle control and signal transduction

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
HSP90 super family cl46693
Hsp90 protein;
18-732 0e+00

Hsp90 protein;


The actual alignment was detected with superfamily member PTZ00272:

Pssm-ID: 481033  Cd Length: 701  Bit Score: 937.17  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146191  18 ETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLDSGKELHINLIPNKQDRTLTIVDTGIG 97
Cdd:PTZ00272   3 ETFAFQAEINQLMSLIINTFYSNKEIFLRELISNASDACDKIRYQSLTDPSVLGESPRLCIRVVPDKENKTLTVEDNGIG 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146191  98 MTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVTVITKHNDDEQYAWESSAGGSFTVRTDTG 177
Cdd:PTZ00272  83 MTKADLVNNLGTIARSGTKAFMEALEAGGDMSMIGQFGVGFYSAYLVADRVTVTSKNNSDESYVWESSAGGTFTITSTPE 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146191 178 EPMGRGTKVILHLKEDQTEYLEERRIKEIVKKHSQFIGYPITLFVEKERDKEVSDDEAEEKEDKEEEKEKEEkesedkpe 257
Cdd:PTZ00272 163 SDMKRGTRITLHLKEDQMEYLEPRRLKELIKKHSEFIGYDIELMVEKTTEKEVTDEDEEDTKKADEDGEEPK-------- 234
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146191 258 IEDVgsDEEEEKKDGDKKKKKKIKEKYIDQeelNKTKPIWTRNPDDITNEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEF 337
Cdd:PTZ00272 235 VEEV--KEGDEGKKKKTKKVKEVTKEYEVQ---NKHKPLWTRDPKDVTKEEYAAFYKAISNDWEDPAATKHFSVEGQLEF 309
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146191 338 RALLFVPRRAPFDLFENRKKKNNIKLYVRRVFIMDNCEELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNLV 417
Cdd:PTZ00272 310 RSIMFVPKRAPFDMFEPNKKRNNIKLYVRRVFIMDNCEDLCPDWLGFVKGVVDSEDLPLNISRENLQQNKILKVIRKNIV 389
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146191 418 KKCLELFTELAEDKENYKKFYEQFSKNIKLGIHEDSQNRKKLSELLRYYTSASGDEMVSLKDYCTRMKENQKHIYYITGE 497
Cdd:PTZ00272 390 KKCLEMFDEVAENKEDYKQFYEQFGKNIKLGIHEDTANRKKLMELLRFYSTESGEEMTTLKDYVTRMKAGQKSIYYITGD 469
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146191 498 TKDQVANSAFVERLRKHGLEVIYMIEPIDEYCVQQLKEFEGKTLVSVTKEGLELPEDEEEKKKQEEKKTKFENLCKIMKD 577
Cdd:PTZ00272 470 SKKKLETSPFIEQARRRGLEVLFMTEPIDEYVMQQVKDFEDKKFACLTKEGVHFEESEEEKQQREEEKAACEKLCKTMKE 549
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146191 578 ILEKKVEKVVVSNRLVTSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMAAKKHLEINPDHSIIETLRQKAEADKNDK 657
Cdd:PTZ00272 550 VLGDKVEKVIVSERLSTSPCILVTSEFGWSAHMEQIMRNQALRDSSMAQYMMSKKTMELNPRHPIIKELRRRVGADENDK 629
                        650       660       670       680       690       700       710
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 154146191 658 SVKDLVILLYETALLSSGFSLEDPQTHANRIYRMIKLGLGIDEDDptaDDTSAAVTEEMPPLEGDDDTSRMEEVD 732
Cdd:PTZ00272 630 AVKDLVFLLFDTSLLTSGFQLEDPTGYAERINRMIKLGLSLDEEE---EEAAEAPVAETAPAEVTAGTSSMEQVD 701
 
Name Accession Description Interval E-value
PTZ00272 PTZ00272
heat shock protein 83 kDa (Hsp83); Provisional
18-732 0e+00

heat shock protein 83 kDa (Hsp83); Provisional


Pssm-ID: 240341  Cd Length: 701  Bit Score: 937.17  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146191  18 ETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLDSGKELHINLIPNKQDRTLTIVDTGIG 97
Cdd:PTZ00272   3 ETFAFQAEINQLMSLIINTFYSNKEIFLRELISNASDACDKIRYQSLTDPSVLGESPRLCIRVVPDKENKTLTVEDNGIG 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146191  98 MTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVTVITKHNDDEQYAWESSAGGSFTVRTDTG 177
Cdd:PTZ00272  83 MTKADLVNNLGTIARSGTKAFMEALEAGGDMSMIGQFGVGFYSAYLVADRVTVTSKNNSDESYVWESSAGGTFTITSTPE 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146191 178 EPMGRGTKVILHLKEDQTEYLEERRIKEIVKKHSQFIGYPITLFVEKERDKEVSDDEAEEKEDKEEEKEKEEkesedkpe 257
Cdd:PTZ00272 163 SDMKRGTRITLHLKEDQMEYLEPRRLKELIKKHSEFIGYDIELMVEKTTEKEVTDEDEEDTKKADEDGEEPK-------- 234
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146191 258 IEDVgsDEEEEKKDGDKKKKKKIKEKYIDQeelNKTKPIWTRNPDDITNEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEF 337
Cdd:PTZ00272 235 VEEV--KEGDEGKKKKTKKVKEVTKEYEVQ---NKHKPLWTRDPKDVTKEEYAAFYKAISNDWEDPAATKHFSVEGQLEF 309
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146191 338 RALLFVPRRAPFDLFENRKKKNNIKLYVRRVFIMDNCEELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNLV 417
Cdd:PTZ00272 310 RSIMFVPKRAPFDMFEPNKKRNNIKLYVRRVFIMDNCEDLCPDWLGFVKGVVDSEDLPLNISRENLQQNKILKVIRKNIV 389
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146191 418 KKCLELFTELAEDKENYKKFYEQFSKNIKLGIHEDSQNRKKLSELLRYYTSASGDEMVSLKDYCTRMKENQKHIYYITGE 497
Cdd:PTZ00272 390 KKCLEMFDEVAENKEDYKQFYEQFGKNIKLGIHEDTANRKKLMELLRFYSTESGEEMTTLKDYVTRMKAGQKSIYYITGD 469
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146191 498 TKDQVANSAFVERLRKHGLEVIYMIEPIDEYCVQQLKEFEGKTLVSVTKEGLELPEDEEEKKKQEEKKTKFENLCKIMKD 577
Cdd:PTZ00272 470 SKKKLETSPFIEQARRRGLEVLFMTEPIDEYVMQQVKDFEDKKFACLTKEGVHFEESEEEKQQREEEKAACEKLCKTMKE 549
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146191 578 ILEKKVEKVVVSNRLVTSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMAAKKHLEINPDHSIIETLRQKAEADKNDK 657
Cdd:PTZ00272 550 VLGDKVEKVIVSERLSTSPCILVTSEFGWSAHMEQIMRNQALRDSSMAQYMMSKKTMELNPRHPIIKELRRRVGADENDK 629
                        650       660       670       680       690       700       710
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 154146191 658 SVKDLVILLYETALLSSGFSLEDPQTHANRIYRMIKLGLGIDEDDptaDDTSAAVTEEMPPLEGDDDTSRMEEVD 732
Cdd:PTZ00272 630 AVKDLVFLLFDTSLLTSGFQLEDPTGYAERINRMIKLGLSLDEEE---EEAAEAPVAETAPAEVTAGTSSMEQVD 701
HSP90 pfam00183
Hsp90 protein;
196-720 0e+00

Hsp90 protein;


Pssm-ID: 459703  Cd Length: 516  Bit Score: 816.02  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146191  196 EYLEERRIKEIVKKHSQFIGYPITLFVEKERDKEVSDDEAEEKEDKEEEKEKEEKesedkpeIEDVGsdeeeekKDGDKK 275
Cdd:pfam00183   1 EYLEEKKIKELVKKYSEFINFPIYLWVEKEEEVEVPDEEEEEEEEEEEEEDDDPK-------VEEED-------EEEEKK 66
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146191  276 KKKKIKEKYIDQEELNKTKPIWTRNPDDITNEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFVPRRAPFDLFENR 355
Cdd:pfam00183  67 KTKKVKETVWEWELLNKTKPIWTRNPKEVTEEEYAEFYKSLSKDWEDPLAVKHFSVEGEVEFKSLLFIPKRAPFDLFENK 146
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146191  356 KKKNNIKLYVRRVFIMDNCEELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNLVKKCLELFTELAEDKENYK 435
Cdd:pfam00183 147 KKKNNIKLYVRRVFITDDFEDLIPEYLNFVKGVVDSDDLPLNVSRETLQQNKILKVIKKKLVRKALDMFKEIAEEKEDYK 226
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146191  436 KFYEQFSKNIKLGIHEDSQNRKKLSELLRYYTSASGDEMVSLKDYCTRMKENQKHIYYITGETKDQVANSAFVERLRKHG 515
Cdd:pfam00183 227 KFWKEFGKNLKLGIIEDSSNRNKLAKLLRFYSSKSGDELTSLDDYVSRMKEGQKHIYYITGESKEEVENSPFLERLKKKG 306
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146191  516 LEVIYMIEPIDEYCVQQLKEFEGKTLVSVTKEGLELPEDEEEKKKQEEKKTKFENLCKIMKDILEKKVEKVVVSNRLVTS 595
Cdd:pfam00183 307 YEVLYLTDPIDEYAVQQLKEFDGKKLVNVAKEGLELEEDEEEKKKDEELKKEFEPLTKWLKDVLGDKVEKVVVSNRLVDS 386
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146191  596 PCCIVTSTYGWTANMERIMKAQALR-DNSTMGYMAAKKHLEINPDHSIIETLRQKAEADKNDKSVKDLVILLYETALLSS 674
Cdd:pfam00183 387 PCVLVTSQYGWSANMERIMKAQALRkDSSMSSYMSSKKTLEINPRHPIIKELLKRVEADKDDKTAKDLALLLYETALLRS 466
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|
gi 154146191  675 GFSLEDPQTHANRIYRMIKLGLGIDEDDPTADD----TSAAVTEEMPPLE 720
Cdd:pfam00183 467 GFSLEDPASFASRIYRMLKLGLGIDEDEIVEEEdeieEEEEEEEEEPEEE 516
HtpG COG0326
Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, ...
16-697 0e+00

Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440095 [Multi-domain]  Cd Length: 616  Bit Score: 736.16  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146191  16 EVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLDSGKELHINLIPNKQDRTLTIVDTG 95
Cdd:COG0326    2 AKETGEFQAEVKQLLDLMIHSLYSNKEIFLRELISNASDAIDKLRFLALTDPELKEEDGDLKIRIEVDKEAKTLTISDNG 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146191  96 IGMTKADLINNLGTIAKSGTKAFMEALQ--AGADISMIGQFGVGFYSAYLVAEKVTVITKH--NDDEQYAWESSAGGSFT 171
Cdd:COG0326   82 IGMTREEVIENLGTIAKSGTREFLEKLKgdQKKDSDLIGQFGVGFYSAFMVADKVEVVTRSagEDAEAVRWESDGDGEYT 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146191 172 VRTDTGEPmgRGTKVILHLKEDQTEYLEERRIKEIVKKHSQFIGYPITLFVEKERDKEVsddeaeekedkeeekekeeke 251
Cdd:COG0326  162 IEEAEKAE--RGTEITLHLKEDAEEFLEEWRLREIIKKYSDFIPVPIKMEGEEEETEED--------------------- 218
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146191 252 sedkpeiedvgsdeeeekkdgdkkkkkkikekyidqEELNKTKPIWTRNPDDITNEEYGEFYKSLTNDWEDHLAVKHFSV 331
Cdd:COG0326  219 ------------------------------------ETINSATALWTRSKSEITDEEYKEFYKHLFHDFEDPLFWIHLNV 262
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146191 332 EGQLEFRALLFVPRRAPFDLFeNRKKKNNIKLYVRRVFIMDNCEELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKV 411
Cdd:COG0326  263 EGPFEYTGLLYIPKKAPFDLY-DRDRKGGIKLYVKRVFIMDDAEDLLPEYLRFVRGVVDSPDLPLNVSREILQEDRQLKK 341
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146191 412 IRKNLVKKCLELFTELAE-DKENYKKFYEQFSKNIKLGIHEDSQNRKKLSELLRYYTSAsGDEMVSLKDYCTRMKENQKH 490
Cdd:COG0326  342 IRKAITKKVLDELEKLAKnDREKYEKFWKEFGLVLKEGALEDFKNREKIADLLRFESTK-EGGYVTLAEYVERMKEGQKK 420
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146191 491 IYYITGETKDQVANSAFVERLRKHGLEVIYMIEPIDEYCVQQLKEFEGKTLVSVTKeGLELPEDEEEKKKQEEKKTKFEN 570
Cdd:COG0326  421 IYYITGESREAAEQSPHLEIFKAKGIEVLLLTDPIDEFLISHLEEFDGKKFKSVDS-GDLDLDKLEEKKESEEEEEEFKP 499
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146191 571 LCKIMKDILEKKVEKVVVSNRLVTSPCCIVTSTYGWTANMERIMKAqalrdnstMG--YMAAKKHLEINPDHSIIETLRq 648
Cdd:COG0326  500 LLERFKEALGDKVKDVRVSARLTDSPACLVADEGDMSRRMEKMLKA--------MGqdMPEAKPILEINPNHPLVKKLA- 570
                        650       660       670       680
                 ....*....|....*....|....*....|....*....|....*....
gi 154146191 649 kaeADKNDKSVKDLVILLYETALLSSGFSLEDPQTHANRIYRMIKLGLG 697
Cdd:COG0326  571 ---AEEDEELFKDLAELLYDQALLAEGGLLEDPAAFVKRLNKLLEKALG 616
HATPase_Hsp90-like cd16927
Histidine kinase-like ATPase domain of human cytosolic Hsp90 and its homologs including ...
28-214 1.55e-112

Histidine kinase-like ATPase domain of human cytosolic Hsp90 and its homologs including Escherichia coli HtpG, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of 90 kilodalton heat-shock protein (Hsp90) eukaryotic homologs including cytosolic Hsp90, mitochondrial TRAP1 (tumor necrosis factor receptor-associated protein 1), GRP94 (94 kDa glucose-regulated protein) of the endoplasmic reticulum (ER), and chloroplast Hsp90C. It also includes the bacterial homologs of Hsp90, known as HtpG (High temperature protein G). Hsp90 family of chaperones assist other proteins to fold correctly, stabilizes them against heat stress, and aids in protein degradation.


Pssm-ID: 340404 [Multi-domain]  Cd Length: 189  Bit Score: 337.96  E-value: 1.55e-112
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146191  28 QLMSLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLDSGKELHINLIPNKQDRTLTIVDTGIGMTKADLINNL 107
Cdd:cd16927    2 QLLDLIIHSLYSNKEIFLRELISNASDALDKLRYLSLTDPSLLDDDPELEIRISPDKENRTLTISDTGIGMTKEELINNL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146191 108 GTIAKSGTKAFMEALQAGA-DISMIGQFGVGFYSAYLVAEKVTVITKHN-DDEQYAWESSAGGSFTVRTDTGEPmGRGTK 185
Cdd:cd16927   82 GTIARSGTKAFLEALQEGAkDSDLIGQFGVGFYSAFMVADKVTVTTKSAgDDEGYRWESDGGGSYTIEEAEGEL-GRGTK 160
                        170       180
                 ....*....|....*....|....*....
gi 154146191 186 VILHLKEDQTEYLEERRIKEIVKKHSQFI 214
Cdd:cd16927  161 ITLHLKEDAKEFLEEARIKELVKKYSDFI 189
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
40-191 8.73e-12

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 62.28  E-value: 8.73e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146191    40 NKEIFLRELISNSSDALDKIRYEsltdpskldsGKELHINLIPNKQDRTLTIVDTGIGMTKADLinnlgtiaksgTKAFM 119
Cdd:smart00387   1 GDPDRLRQVLSNLLDNAIKYTPE----------GGRITVTLERDGDHVEITVEDNGPGIPPEDL-----------EKIFE 59
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 154146191   120 EALQAGADISMIGQFGVGFYSAYLVAEKVtvitkhnddeqyawessaGGSFTVRTDTgepmGRGTKVILHLK 191
Cdd:smart00387  60 PFFRTDKRSRKIGGTGLGLSIVKKLVELH------------------GGEISVESEP----GGGTTFTITLP 109
 
Name Accession Description Interval E-value
PTZ00272 PTZ00272
heat shock protein 83 kDa (Hsp83); Provisional
18-732 0e+00

heat shock protein 83 kDa (Hsp83); Provisional


Pssm-ID: 240341  Cd Length: 701  Bit Score: 937.17  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146191  18 ETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLDSGKELHINLIPNKQDRTLTIVDTGIG 97
Cdd:PTZ00272   3 ETFAFQAEINQLMSLIINTFYSNKEIFLRELISNASDACDKIRYQSLTDPSVLGESPRLCIRVVPDKENKTLTVEDNGIG 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146191  98 MTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVTVITKHNDDEQYAWESSAGGSFTVRTDTG 177
Cdd:PTZ00272  83 MTKADLVNNLGTIARSGTKAFMEALEAGGDMSMIGQFGVGFYSAYLVADRVTVTSKNNSDESYVWESSAGGTFTITSTPE 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146191 178 EPMGRGTKVILHLKEDQTEYLEERRIKEIVKKHSQFIGYPITLFVEKERDKEVSDDEAEEKEDKEEEKEKEEkesedkpe 257
Cdd:PTZ00272 163 SDMKRGTRITLHLKEDQMEYLEPRRLKELIKKHSEFIGYDIELMVEKTTEKEVTDEDEEDTKKADEDGEEPK-------- 234
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146191 258 IEDVgsDEEEEKKDGDKKKKKKIKEKYIDQeelNKTKPIWTRNPDDITNEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEF 337
Cdd:PTZ00272 235 VEEV--KEGDEGKKKKTKKVKEVTKEYEVQ---NKHKPLWTRDPKDVTKEEYAAFYKAISNDWEDPAATKHFSVEGQLEF 309
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146191 338 RALLFVPRRAPFDLFENRKKKNNIKLYVRRVFIMDNCEELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNLV 417
Cdd:PTZ00272 310 RSIMFVPKRAPFDMFEPNKKRNNIKLYVRRVFIMDNCEDLCPDWLGFVKGVVDSEDLPLNISRENLQQNKILKVIRKNIV 389
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146191 418 KKCLELFTELAEDKENYKKFYEQFSKNIKLGIHEDSQNRKKLSELLRYYTSASGDEMVSLKDYCTRMKENQKHIYYITGE 497
Cdd:PTZ00272 390 KKCLEMFDEVAENKEDYKQFYEQFGKNIKLGIHEDTANRKKLMELLRFYSTESGEEMTTLKDYVTRMKAGQKSIYYITGD 469
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146191 498 TKDQVANSAFVERLRKHGLEVIYMIEPIDEYCVQQLKEFEGKTLVSVTKEGLELPEDEEEKKKQEEKKTKFENLCKIMKD 577
Cdd:PTZ00272 470 SKKKLETSPFIEQARRRGLEVLFMTEPIDEYVMQQVKDFEDKKFACLTKEGVHFEESEEEKQQREEEKAACEKLCKTMKE 549
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146191 578 ILEKKVEKVVVSNRLVTSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMAAKKHLEINPDHSIIETLRQKAEADKNDK 657
Cdd:PTZ00272 550 VLGDKVEKVIVSERLSTSPCILVTSEFGWSAHMEQIMRNQALRDSSMAQYMMSKKTMELNPRHPIIKELRRRVGADENDK 629
                        650       660       670       680       690       700       710
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 154146191 658 SVKDLVILLYETALLSSGFSLEDPQTHANRIYRMIKLGLGIDEDDptaDDTSAAVTEEMPPLEGDDDTSRMEEVD 732
Cdd:PTZ00272 630 AVKDLVFLLFDTSLLTSGFQLEDPTGYAERINRMIKLGLSLDEEE---EEAAEAPVAETAPAEVTAGTSSMEQVD 701
HSP90 pfam00183
Hsp90 protein;
196-720 0e+00

Hsp90 protein;


Pssm-ID: 459703  Cd Length: 516  Bit Score: 816.02  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146191  196 EYLEERRIKEIVKKHSQFIGYPITLFVEKERDKEVSDDEAEEKEDKEEEKEKEEKesedkpeIEDVGsdeeeekKDGDKK 275
Cdd:pfam00183   1 EYLEEKKIKELVKKYSEFINFPIYLWVEKEEEVEVPDEEEEEEEEEEEEEDDDPK-------VEEED-------EEEEKK 66
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146191  276 KKKKIKEKYIDQEELNKTKPIWTRNPDDITNEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFVPRRAPFDLFENR 355
Cdd:pfam00183  67 KTKKVKETVWEWELLNKTKPIWTRNPKEVTEEEYAEFYKSLSKDWEDPLAVKHFSVEGEVEFKSLLFIPKRAPFDLFENK 146
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146191  356 KKKNNIKLYVRRVFIMDNCEELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNLVKKCLELFTELAEDKENYK 435
Cdd:pfam00183 147 KKKNNIKLYVRRVFITDDFEDLIPEYLNFVKGVVDSDDLPLNVSRETLQQNKILKVIKKKLVRKALDMFKEIAEEKEDYK 226
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146191  436 KFYEQFSKNIKLGIHEDSQNRKKLSELLRYYTSASGDEMVSLKDYCTRMKENQKHIYYITGETKDQVANSAFVERLRKHG 515
Cdd:pfam00183 227 KFWKEFGKNLKLGIIEDSSNRNKLAKLLRFYSSKSGDELTSLDDYVSRMKEGQKHIYYITGESKEEVENSPFLERLKKKG 306
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146191  516 LEVIYMIEPIDEYCVQQLKEFEGKTLVSVTKEGLELPEDEEEKKKQEEKKTKFENLCKIMKDILEKKVEKVVVSNRLVTS 595
Cdd:pfam00183 307 YEVLYLTDPIDEYAVQQLKEFDGKKLVNVAKEGLELEEDEEEKKKDEELKKEFEPLTKWLKDVLGDKVEKVVVSNRLVDS 386
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146191  596 PCCIVTSTYGWTANMERIMKAQALR-DNSTMGYMAAKKHLEINPDHSIIETLRQKAEADKNDKSVKDLVILLYETALLSS 674
Cdd:pfam00183 387 PCVLVTSQYGWSANMERIMKAQALRkDSSMSSYMSSKKTLEINPRHPIIKELLKRVEADKDDKTAKDLALLLYETALLRS 466
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|
gi 154146191  675 GFSLEDPQTHANRIYRMIKLGLGIDEDDPTADD----TSAAVTEEMPPLE 720
Cdd:pfam00183 467 GFSLEDPASFASRIYRMLKLGLGIDEDEIVEEEdeieEEEEEEEEEPEEE 516
PRK05218 PRK05218
heat shock protein 90; Provisional
16-697 0e+00

heat shock protein 90; Provisional


Pssm-ID: 235366 [Multi-domain]  Cd Length: 613  Bit Score: 756.18  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146191  16 EVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLDSGKELHINLIPNKQDRTLTIVDTG 95
Cdd:PRK05218   2 AMETGEFQAEVKQLLHLMIHSLYSNKEIFLRELISNASDAIDKLRFEALTDPALYEGDGDLKIRISFDKEARTLTISDNG 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146191  96 IGMTKADLINNLGTIAKSGTKAFMEALQ--AGADISMIGQFGVGFYSAYLVAEKVTVITKH--NDDEQYAWESSAGGSFT 171
Cdd:PRK05218  82 IGMTREEVIENLGTIAKSGTKEFLEKLKgdQKKDSQLIGQFGVGFYSAFMVADKVTVITRSagPAAEAVRWESDGEGEYT 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146191 172 VRTDTGEPmgRGTKVILHLKEDQTEYLEERRIKEIVKKHSQFIGYPITLFVEKErdkevsddeaeekedkeeekekeeke 251
Cdd:PRK05218 162 IEEIEKEE--RGTEITLHLKEDEDEFLDEWRIRSIIKKYSDFIPVPIKLEKEEE-------------------------- 213
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146191 252 sedkpeiedvgsdeeeekkdgdkkkkkkikekyidqEELNKTKPIWTRNPDDITNEEYGEFYKSLTNDWEDHLAVKHFSV 331
Cdd:PRK05218 214 ------------------------------------ETINSASALWTRSKSEITDEEYKEFYKHLAHDFDDPLFWIHNNV 257
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146191 332 EGQLEFRALLFVPRRAPFDLFeNRKKKNNIKLYVRRVFIMDNCEELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKV 411
Cdd:PRK05218 258 EGPFEYTGLLYIPKKAPFDLF-NRDRKGGLKLYVKRVFIMDDAEELLPEYLRFVKGVIDSEDLPLNVSREILQEDRVVKK 336
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146191 412 IRKNLVKKCLELFTELAE-DKENYKKFYEQFSKNIKLGIHEDSQNRKKLSELLRYYTSASGdEMVSLKDYCTRMKENQKH 490
Cdd:PRK05218 337 IRKAITKKVLDELEKLAKnDREKYEKFWKEFGPVLKEGLYEDFANREKLAKLLRFASTHEG-KYVSLAEYVERMKEGQKK 415
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146191 491 IYYITGETKDQVANSAFVERLRKHGLEVIYMIEPIDEYCVQQLKEFEGKTLVSVTKEGLE-LPEDEEEKKKQEEKKTKFE 569
Cdd:PRK05218 416 IYYITGDSREAAKNSPHLELFKKKGIEVLLLTDPIDEFWISYLEEFDGKPFKSVARGDLDlGKEDEEEKEEKEEAEEEFK 495
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146191 570 NLCKIMKDILEKKVEKVVVSNRLVTSPCCIVTSTYGWTANMERIMKAQAlrdnstMGYMAAKKHLEINPDHSIIETLRQk 649
Cdd:PRK05218 496 PLLERLKEALGDKVKDVRLSHRLTDSPACLVADEGDMSTQMEKLLKAAG------QEVPESKPILEINPNHPLVKKLAD- 568
                        650       660       670       680
                 ....*....|....*....|....*....|....*....|....*...
gi 154146191 650 aeaDKNDKSVKDLVILLYETALLSSGFSLEDPQTHANRIYRMIKLGLG 697
Cdd:PRK05218 569 ---EADEAKFKDLAELLYDQALLAEGGSLEDPAAFVKRLNELLLKLLA 613
HtpG COG0326
Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, ...
16-697 0e+00

Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440095 [Multi-domain]  Cd Length: 616  Bit Score: 736.16  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146191  16 EVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLDSGKELHINLIPNKQDRTLTIVDTG 95
Cdd:COG0326    2 AKETGEFQAEVKQLLDLMIHSLYSNKEIFLRELISNASDAIDKLRFLALTDPELKEEDGDLKIRIEVDKEAKTLTISDNG 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146191  96 IGMTKADLINNLGTIAKSGTKAFMEALQ--AGADISMIGQFGVGFYSAYLVAEKVTVITKH--NDDEQYAWESSAGGSFT 171
Cdd:COG0326   82 IGMTREEVIENLGTIAKSGTREFLEKLKgdQKKDSDLIGQFGVGFYSAFMVADKVEVVTRSagEDAEAVRWESDGDGEYT 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146191 172 VRTDTGEPmgRGTKVILHLKEDQTEYLEERRIKEIVKKHSQFIGYPITLFVEKERDKEVsddeaeekedkeeekekeeke 251
Cdd:COG0326  162 IEEAEKAE--RGTEITLHLKEDAEEFLEEWRLREIIKKYSDFIPVPIKMEGEEEETEED--------------------- 218
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146191 252 sedkpeiedvgsdeeeekkdgdkkkkkkikekyidqEELNKTKPIWTRNPDDITNEEYGEFYKSLTNDWEDHLAVKHFSV 331
Cdd:COG0326  219 ------------------------------------ETINSATALWTRSKSEITDEEYKEFYKHLFHDFEDPLFWIHLNV 262
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146191 332 EGQLEFRALLFVPRRAPFDLFeNRKKKNNIKLYVRRVFIMDNCEELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKV 411
Cdd:COG0326  263 EGPFEYTGLLYIPKKAPFDLY-DRDRKGGIKLYVKRVFIMDDAEDLLPEYLRFVRGVVDSPDLPLNVSREILQEDRQLKK 341
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146191 412 IRKNLVKKCLELFTELAE-DKENYKKFYEQFSKNIKLGIHEDSQNRKKLSELLRYYTSAsGDEMVSLKDYCTRMKENQKH 490
Cdd:COG0326  342 IRKAITKKVLDELEKLAKnDREKYEKFWKEFGLVLKEGALEDFKNREKIADLLRFESTK-EGGYVTLAEYVERMKEGQKK 420
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146191 491 IYYITGETKDQVANSAFVERLRKHGLEVIYMIEPIDEYCVQQLKEFEGKTLVSVTKeGLELPEDEEEKKKQEEKKTKFEN 570
Cdd:COG0326  421 IYYITGESREAAEQSPHLEIFKAKGIEVLLLTDPIDEFLISHLEEFDGKKFKSVDS-GDLDLDKLEEKKESEEEEEEFKP 499
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146191 571 LCKIMKDILEKKVEKVVVSNRLVTSPCCIVTSTYGWTANMERIMKAqalrdnstMG--YMAAKKHLEINPDHSIIETLRq 648
Cdd:COG0326  500 LLERFKEALGDKVKDVRVSARLTDSPACLVADEGDMSRRMEKMLKA--------MGqdMPEAKPILEINPNHPLVKKLA- 570
                        650       660       670       680
                 ....*....|....*....|....*....|....*....|....*....
gi 154146191 649 kaeADKNDKSVKDLVILLYETALLSSGFSLEDPQTHANRIYRMIKLGLG 697
Cdd:COG0326  571 ---AEEDEELFKDLAELLYDQALLAEGGLLEDPAAFVKRLNKLLEKALG 616
PTZ00130 PTZ00130
heat shock protein 90; Provisional
3-732 7.04e-163

heat shock protein 90; Provisional


Pssm-ID: 185466 [Multi-domain]  Cd Length: 814  Bit Score: 490.32  E-value: 7.04e-163
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146191   3 EETQTQDQPMEEeeVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLDSGKELHINLIP 82
Cdd:PTZ00130  53 PEIEDGEKPTSG--IEQHQYQTEVTRLMDIIVNSLYTQKEVFLRELISNAADALEKIRFLSLSDESVLGEEKKLEIRISA 130
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146191  83 NKQDRTLTIVDTGIGMTKADLINNLGTIAKSGTKAFMEAL-QAGADISMIGQFGVGFYSAYLVAEKVTVITKHNDDEQYA 161
Cdd:PTZ00130 131 NKEKNILSITDTGIGMTKEDLINNLGTIAKSGTSNFLEAIsKSGGDMSLIGQFGVGFYSAFLVADKVIVYTKNNNDEQYI 210
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146191 162 WESSAGGSFTVRTDT-GEPMGRGTKVILHLKEDQTEYLEERRIKEIVKKHSQFIGYPITLFVEKERDKEVsddeaeeked 240
Cdd:PTZ00130 211 WESTADAKFTIYKDPrGSTLKRGTRISLHLKEDATNLMNDKKLVDLISKYSQFIQYPIYLLHENVYTEEV---------- 280
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146191 241 keeekekeeKESEDKPEIEDVGSDEEEEKKDGDKKKKKKIKEKYIDQEEL-NKTKPIWTRNPDDITNEEYGEFYKSLTND 319
Cdd:PTZ00130 281 ---------LADIAKEMENDPNYDSVKVEETDDPNKKTRTVEKKVKKWKLmNEQKPIWLRPPKELTDEDYKKFFSVLSGF 351
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146191 320 WEDHLAVKHFSVEGQLEFRALLFVPRRAPFDLFENRKKKNNIKLYVRRVFIMDNCEELIPEYLNFIRGVVDSEDLPLNIS 399
Cdd:PTZ00130 352 NDEPLYHIHFFAEGEIEFKCLIYIPSRAPSINDHLFTKQNSIKLYVRRVLVADEFVEFLPRYMSFVKGVVDSDDLPLNVS 431
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146191 400 REMLQQSKILKVIRKNLVKKCLE----LFTELAEDKEN--------------------------YKKFYEQFSKNIKLGI 449
Cdd:PTZ00130 432 REQLQQNKILKAVSKRIVRKILDtfrtLYKEGKKNKETlraelaketdeekkkeiqkkinepstYKLIYKEYRKYLKTGC 511
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146191 450 HEDSQNRKKLSELLRYYTSASgDEMVSLKDYCTRMKENQKHIYYITGETKDQVANSAFVERLRKHGLEVIYMIEPIDEYC 529
Cdd:PTZ00130 512 YEDDINRNKIVKLLLFKTMLH-PKSISLDTYIENMKPDQKFIYYASGDSYEYLSKIPQLQIFKKKNIDVVFLTESVDESC 590
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146191 530 VQQLKEFEGKTLVSVTKEGLELPEDEEEKKKQEEKKTKFENLCKIMKDILEKKVEKVVVSNRLVTSPCCIVTSTYGWTAN 609
Cdd:PTZ00130 591 VQRVQEYDGKKFKSIQKGEITFELTEDEKKKEEKVKKMYKALIDVISDTLRNQIFKVEISRRLVDAPCAVVSTEWGLSGQ 670
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146191 610 MERIMKAQaLRDNSTMGYMAAKKHLEINPDHSIIETLRQKAEADKNDKSVKDLVILLYETALLSSGFSLEDPQTHANRIY 689
Cdd:PTZ00130 671 MEKLMKIN-VNNSDQIKAMSGQKILEINPDHPIMIDLLKRSVSNPKDSQLTESIKIIYQSAKLASGFDLEDTADLAQIVY 749
                        730       740       750       760
                 ....*....|....*....|....*....|....*....|....
gi 154146191 690 RMIKLGLGIDEDDPTAD-DTSAAVTEEMPPLEGDDDTSRMEEVD 732
Cdd:PTZ00130 750 DHINQKLGVDNNLKIDDlDPAIFETKKIEQEDSPDGQKFHEEIN 793
HATPase_Hsp90-like cd16927
Histidine kinase-like ATPase domain of human cytosolic Hsp90 and its homologs including ...
28-214 1.55e-112

Histidine kinase-like ATPase domain of human cytosolic Hsp90 and its homologs including Escherichia coli HtpG, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of 90 kilodalton heat-shock protein (Hsp90) eukaryotic homologs including cytosolic Hsp90, mitochondrial TRAP1 (tumor necrosis factor receptor-associated protein 1), GRP94 (94 kDa glucose-regulated protein) of the endoplasmic reticulum (ER), and chloroplast Hsp90C. It also includes the bacterial homologs of Hsp90, known as HtpG (High temperature protein G). Hsp90 family of chaperones assist other proteins to fold correctly, stabilizes them against heat stress, and aids in protein degradation.


Pssm-ID: 340404 [Multi-domain]  Cd Length: 189  Bit Score: 337.96  E-value: 1.55e-112
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146191  28 QLMSLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLDSGKELHINLIPNKQDRTLTIVDTGIGMTKADLINNL 107
Cdd:cd16927    2 QLLDLIIHSLYSNKEIFLRELISNASDALDKLRYLSLTDPSLLDDDPELEIRISPDKENRTLTISDTGIGMTKEELINNL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146191 108 GTIAKSGTKAFMEALQAGA-DISMIGQFGVGFYSAYLVAEKVTVITKHN-DDEQYAWESSAGGSFTVRTDTGEPmGRGTK 185
Cdd:cd16927   82 GTIARSGTKAFLEALQEGAkDSDLIGQFGVGFYSAFMVADKVTVTTKSAgDDEGYRWESDGGGSYTIEEAEGEL-GRGTK 160
                        170       180
                 ....*....|....*....|....*....
gi 154146191 186 VILHLKEDQTEYLEERRIKEIVKKHSQFI 214
Cdd:cd16927  161 ITLHLKEDAKEFLEEARIKELVKKYSDFI 189
PRK14083 PRK14083
HSP90 family protein; Provisional
21-416 3.20e-32

HSP90 family protein; Provisional


Pssm-ID: 237603 [Multi-domain]  Cd Length: 601  Bit Score: 132.76  E-value: 3.20e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146191  21 AFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDAldkIRYESLTDPSklDSGKeLHINLiPNKQDRTLTIVDTGIGMTK 100
Cdd:PRK14083   4 RFQVDLRGVIDLLSRHLYSSPRVYVRELLQNAVDA---ITARRALDPT--APGR-IRIEL-TDAGGGTLIVEDNGIGLTE 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146191 101 ADLINNLGTIAKSGTKAfmEALQAGADiSMIGQFGVGFYSAYLVAEKVTVITKHNDDEQ-YAWESSAGGSFTVRTDTGEP 179
Cdd:PRK14083  77 EEVHEFLATIGRSSKRD--ENLGFARN-DFLGQFGIGLLSCFLVADEIVVVSRSAKDGPaVEWRGKADGTYSVRKLETER 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146191 180 MGRGTKVILHLKEDQTEYLEERRIKEIVKKHSQFIGYPITLFVEKERdkevsddeaeekedkeeekekeekesedkpeie 259
Cdd:PRK14083 154 AEPGTTVYLRPRPDAEEWLERETVEELAKKYGSLLPVPIRVEGEKGG--------------------------------- 200
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146191 260 dvgsdeeeekkdgdkkkkkkikekyidqeeLNKTKPIWTRNPDDITNE-----EYGEfyKSLTNDWEDH--LAVKHFSVE 332
Cdd:PRK14083 201 ------------------------------VNETPPPWTRDYPDPETRreallAYGE--ELLGFTPLDVipLDVPSGGLE 248
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146191 333 GqlefraLLFV-PRRAPFdlfeNRKKKNniKLYVRRVFIMDNCEELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKV 411
Cdd:PRK14083 249 G------VAYVlPYAVSP----AARRKH--RVYLKRMLLSEEAENLLPDWAFFVRCVVNTDELRPTASREALYEDDALAA 316

                 ....*
gi 154146191 412 IRKNL 416
Cdd:PRK14083 317 VREEL 321
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
40-191 8.73e-12

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 62.28  E-value: 8.73e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146191    40 NKEIFLRELISNSSDALDKIRYEsltdpskldsGKELHINLIPNKQDRTLTIVDTGIGMTKADLinnlgtiaksgTKAFM 119
Cdd:smart00387   1 GDPDRLRQVLSNLLDNAIKYTPE----------GGRITVTLERDGDHVEITVEDNGPGIPPEDL-----------EKIFE 59
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 154146191   120 EALQAGADISMIGQFGVGFYSAYLVAEKVtvitkhnddeqyawessaGGSFTVRTDTgepmGRGTKVILHLK 191
Cdd:smart00387  60 PFFRTDKRSRKIGGTGLGLSIVKKLVELH------------------GGEISVESEP----GGGTTFTITLP 109
HATPase_c_3 pfam13589
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, ...
42-159 6.25e-09

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 433332 [Multi-domain]  Cd Length: 135  Bit Score: 55.03  E-value: 6.25e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146191   42 EIFLRELISNSSDAldkiryesltdpskldSGKELHINLIPNKQDRT-LTIVDTGIGMTKADLINNLGtIAKSGTKafme 120
Cdd:pfam13589   2 EGALAELIDNSIDA----------------DATNIKIEVNKNRGGGTeIVIEDDGHGMSPEELINALR-LATSAKE---- 60
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 154146191  121 alqAGADISMIGQFGVGFYSAYLV-AEKVTVITKHNDDEQ 159
Cdd:pfam13589  61 ---AKRGSTDLGRYGIGLKLASLSlGAKLTVTSKKEGKSS 97
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
40-194 9.89e-06

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 45.05  E-value: 9.89e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154146191   40 NKEIFLRELISNSSDALDKIRYEsltdpskldsGKELHINLIPnKQDRTLTIVDTGIGMTKADLinnlgtiAKSGTKaFM 119
Cdd:pfam02518   1 GDELRLRQVLSNLLDNALKHAAK----------AGEITVTLSE-GGELTLTVEDNGIGIPPEDL-------PRIFEP-FS 61
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 154146191  120 EalqagADISMIGQFGVGFYSAYLVAEKVtvitkhnddeqyawessaGGSFTVRTDTgepmGRGTKVILHLKEDQ 194
Cdd:pfam02518  62 T-----ADKRGGGGTGLGLSIVRKLVELL------------------GGTITVESEP----GGGTTVTLTLPLAQ 109
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH