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Conserved domains on  [gi|4885657|ref|NP_005422|]
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DNA repair protein XRCC2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
XRCC2 cd19490
XRCC2 recombinase; XRCC2 (X-ray repair complementing defective repair in Chinese hamster cells ...
 41-243 1.81e-89

XRCC2 recombinase; XRCC2 (X-ray repair complementing defective repair in Chinese hamster cells 2) recombinase, a RAD51 paralog, plays an important role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. XRCC2, together with the other RAD51 paralogs, RAD51B, RAD51C, RAD51D, and XRCC3, helps recruit RAD51 to the break site.


:

Pssm-ID: 410898 [Multi-domain]  Cd Length: 226  Bit Score: 264.98  E-value: 1.81e-89
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885657   41 GDILEFHGPEGTGKTEMLYHLTARCILPKSE-----GGLEVEVLFIDTDYHFDMLRLVTILEHRLSQS------------ 103
Cdd:cd19490   1 GDVIEITGPSGSGKTELLYHLAARCILPSSWggvplGGLEAAVVFIDTDGRFDILRLRSILEARIRAAiqaanssddeed 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885657  104 SEEIIKYCLGRFFLVYCSSSTHLLLTLYSLESMFCS---HPSLCLLILDSLSAFYWIDRVNGGES---VNLQESTLRKCS 177
Cdd:cd19490  81 VEEIARECLQRLHIFRCHSSLQLLATLLSLENYLLSlsaNPELGLLLIDSISAFYWQDRFSAELAraaPLLQEAALRAIL 160

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4885657  178 QCLEKLVNDYRLVLFATTQTIMQKASSSSEEPSHASRRLCDVDIDYRPYLCKAWQQLVKHRMFFSK 243
Cdd:cd19490 161 RELRRLRRRFQLVVIATKQALFPGKSASTDNPAANNAVSKASAPSHREYLPRPWQRLVTHRLVLSR 226
 
Name Accession Description Interval E-value
XRCC2 cd19490
XRCC2 recombinase; XRCC2 (X-ray repair complementing defective repair in Chinese hamster cells ...
 41-243 1.81e-89

XRCC2 recombinase; XRCC2 (X-ray repair complementing defective repair in Chinese hamster cells 2) recombinase, a RAD51 paralog, plays an important role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. XRCC2, together with the other RAD51 paralogs, RAD51B, RAD51C, RAD51D, and XRCC3, helps recruit RAD51 to the break site.


Pssm-ID: 410898 [Multi-domain]  Cd Length: 226  Bit Score: 264.98  E-value: 1.81e-89
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885657   41 GDILEFHGPEGTGKTEMLYHLTARCILPKSE-----GGLEVEVLFIDTDYHFDMLRLVTILEHRLSQS------------ 103
Cdd:cd19490   1 GDVIEITGPSGSGKTELLYHLAARCILPSSWggvplGGLEAAVVFIDTDGRFDILRLRSILEARIRAAiqaanssddeed 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885657  104 SEEIIKYCLGRFFLVYCSSSTHLLLTLYSLESMFCS---HPSLCLLILDSLSAFYWIDRVNGGES---VNLQESTLRKCS 177
Cdd:cd19490  81 VEEIARECLQRLHIFRCHSSLQLLATLLSLENYLLSlsaNPELGLLLIDSISAFYWQDRFSAELAraaPLLQEAALRAIL 160

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4885657  178 QCLEKLVNDYRLVLFATTQTIMQKASSSSEEPSHASRRLCDVDIDYRPYLCKAWQQLVKHRMFFSK 243
Cdd:cd19490 161 RELRRLRRRFQLVVIATKQALFPGKSASTDNPAANNAVSKASAPSHREYLPRPWQRLVTHRLVLSR 226
Rad51 pfam08423
Rad51; Rad51 is a DNA repair and recombination protein and is a homolog of the bacterial ...
 41-206 5.62e-12

Rad51; Rad51 is a DNA repair and recombination protein and is a homolog of the bacterial ATPase RecA protein.


Pssm-ID: 462471 [Multi-domain]  Cd Length: 255  Bit Score: 64.25  E-value: 5.62e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885657     41 GDILEFHGPEGTGKTEMLYHLTARCILPKSEGGLEVEVLFIDTDYHFDMLRLVTILEhRLSQSSEEIIKYCLG-RFFlvy 119
Cdd:pfam08423  37 GSITEIFGEFRTGKTQLCHTLCVTCQLPLEMGGGEGKALYIDTEGTFRPERLVAIAE-RYGLDPEDVLDNVAYaRAY--- 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885657    120 csSSTHLLLTLYSLESMFCSHPsLCLLILDSLSAFYWIDRVNGGEsVNLQESTLRKCSQCLEKLVNDYRLVLFATTQTIM 199
Cdd:pfam08423 113 --NSEHQMQLLQQAAAMMSESR-FALLIVDSATALYRTDFSGRGE-LAERQQHLAKFLRTLQRLADEFGVAVVITNQVVA 188


                  ....*..
gi 4885657    200 QKASSSS 206
Cdd:pfam08423 189 QVDGAAG 195
recomb_radA TIGR02236
DNA repair and recombination protein RadA; This family consists exclusively of archaeal RadA ...
 9-196 2.35e-10

DNA repair and recombination protein RadA; This family consists exclusively of archaeal RadA protein, a homolog of bacterial RecA (TIGR02012), eukaryotic RAD51 (TIGR02239), and archaeal RadB (TIGR02237). This protein is involved in DNA repair and recombination. The member from Pyrococcus horikoshii contains an intein. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 131290 [Multi-domain]  Cd Length: 310  Bit Score: 60.14  E-value: 2.35e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885657      9 ESGTELLARlegRSSLKEIEPNLfADEDSPVHG-----DILEFHGPEGTGKTEMLYHLTARCILPKSEGGLEVEVLFIDT 83
Cdd:TIGR02236  62 ETADDVLER---RKTIGKITTGS-KELDELLGGgietqAITEVFGEFGSGKTQICHQLAVNVQLPEEKGGLGGKAVYIDT 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885657     84 DYHFDMLRLVTILEHRLSQSSEEIIKYCLGRFFlvycsSSTHLLLTLYSLESMFCSH-PSLCLLILDSLSAFYWIDRVNG 162
Cdd:TIGR02236 138 ENTFRPERIMQMAEARGLDPDEVLKNIYVARAY-----NSNHQMLLVEKAEDLIKELnNPVKLLIVDSLTSHFRAEYVGR 212

                         170       180       190
                  ....*....|....*....|....*....|....
gi 4885657    163 GESVNLQEStLRKCSQCLEKLVNDYRLVLFATTQ 196
Cdd:TIGR02236 213 GALAERQQK-LNKHLHDLLRLADLYNAAVVVTNQ 245
PTZ00035 PTZ00035
Rad51 protein; Provisional
 41-206 5.90e-10

Rad51 protein; Provisional


Pssm-ID: 185407 [Multi-domain]  Cd Length: 337  Bit Score: 58.86  E-value: 5.90e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885657    41 GDILEFHGPEGTGKTEMLYHLTARCILPKSEGGLEVEVLFIDTDYHFDMLRLVTILEhRLSQSSEEiikyCLGRFFLVYC 120
Cdd:PTZ00035 118 GSITELFGEFRTGKTQLCHTLCVTCQLPIEQGGGEGKVLYIDTEGTFRPERIVQIAE-RFGLDPED----VLDNIAYARA 192

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885657   121 SSSTHLLLTLYSLESMFCSHPsLCLLILDSLSAFYWIDRVNGGESVNLQEStLRKCSQCLEKLVNDYRLVLFATTQTIMQ 200
Cdd:PTZ00035 193 YNHEHQMQLLSQAAAKMAEER-FALLIVDSATALFRVDYSGRGELAERQQH-LGKFLRALQKLADEFNVAVVITNQVMAD 270


                 ....*.
gi 4885657   201 KASSSS 206
Cdd:PTZ00035 271 VDGASM 276
 
Name Accession Description Interval E-value
XRCC2 cd19490
XRCC2 recombinase; XRCC2 (X-ray repair complementing defective repair in Chinese hamster cells ...
 41-243 1.81e-89

XRCC2 recombinase; XRCC2 (X-ray repair complementing defective repair in Chinese hamster cells 2) recombinase, a RAD51 paralog, plays an important role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. XRCC2, together with the other RAD51 paralogs, RAD51B, RAD51C, RAD51D, and XRCC3, helps recruit RAD51 to the break site.


Pssm-ID: 410898 [Multi-domain]  Cd Length: 226  Bit Score: 264.98  E-value: 1.81e-89
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885657   41 GDILEFHGPEGTGKTEMLYHLTARCILPKSE-----GGLEVEVLFIDTDYHFDMLRLVTILEHRLSQS------------ 103
Cdd:cd19490   1 GDVIEITGPSGSGKTELLYHLAARCILPSSWggvplGGLEAAVVFIDTDGRFDILRLRSILEARIRAAiqaanssddeed 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885657  104 SEEIIKYCLGRFFLVYCSSSTHLLLTLYSLESMFCS---HPSLCLLILDSLSAFYWIDRVNGGES---VNLQESTLRKCS 177
Cdd:cd19490  81 VEEIARECLQRLHIFRCHSSLQLLATLLSLENYLLSlsaNPELGLLLIDSISAFYWQDRFSAELAraaPLLQEAALRAIL 160

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4885657  178 QCLEKLVNDYRLVLFATTQTIMQKASSSSEEPSHASRRLCDVDIDYRPYLCKAWQQLVKHRMFFSK 243
Cdd:cd19490 161 RELRRLRRRFQLVVIATKQALFPGKSASTDNPAANNAVSKASAPSHREYLPRPWQRLVTHRLVLSR 226
RecA-like cd01393
RecA family; RecA is a bacterial enzyme which has roles in homologous recombination, DNA ...
 41-243 2.48e-58

RecA family; RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange. While prokaryotes have a single RecA protein, eukaryotes have multiple RecA homologs such as Rad51, DMC1 and Rad55/57. Archaea have the RecA-like homologs RadA and RadB.


Pssm-ID: 410881 [Multi-domain]  Cd Length: 185  Bit Score: 184.48  E-value: 2.48e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885657   41 GDILEFHGPEGTGKTEMLYHLTARCILpkseggLEVEVLFIDTDYHFDMLRLVTILEHrlSQSSEEIIKYCLGRFFLVYC 120
Cdd:cd01393   1 GKITEIYGPPGSGKTQLALQLAANALL------LGGGVVWIDTEGAFPPSRLVQILEA--SPSSELELAEALSRLLYFRP 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885657  121 S-SSTHLLLTLYSLESMFCShPSLCLLILDSLSAFYWIDRVNGGE---SVNLQESTLRKCSQCLEKLVNDYRLVLFATTQ 196
Cdd:cd01393  73 PdTLAHLLALDSLPESLFPP-PNTSLVVVDSVSALFRKAFPRGGDgdsSSSLRARLLSQLARALQKLAAQFNLAVVVTNQ 151

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 4885657  197 TIMQKASSSseepshasrrlcdVDIDYRPYLCKAWQQLVKHRMFFSK 243
Cdd:cd01393 152 VTTKIRGGS-------------GASLVPPALGNTWEHSVSTRLLLYR 185
Rad51B cd19493
RAD51B recombinase; RAD51B recombinase, a RAD51 paralog, plays an important role in DNA repair ...
 41-260 1.14e-15

RAD51B recombinase; RAD51B recombinase, a RAD51 paralog, plays an important role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. RAD51B, together with the other RAD51 paralogs, RAD51C, RAD51D, XRCC3, and XRCC2, helps recruit RAD51 to the break site.


Pssm-ID: 410901 [Multi-domain]  Cd Length: 222  Bit Score: 73.89  E-value: 1.14e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885657   41 GDILEFHGPEGTGKTEMLYHLTARCILPKSEGGLEVEVLFIDTDYHFDMLRLVTILEHR------LSQSSEEIIKYCLGR 114
Cdd:cd19493  11 GAITEITGASGSGKTQFALTLASSAAMPARKGGLDGGVLYIDTESKFSAERLAEIAEARfpeafsGFMEENERAEEMLKR 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885657  115 FFLVYCSSSTHLLLTLYSL-ESMFCSHPSlcLLILDSLSAFYwiDRVNGGESVNLQE--STLRKCSQCLEKLVNDYRLVL 191
Cdd:cd19493  91 VAVVRVTTLAQLLERLPNLeEHILSSGVR--LVVIDSIAALV--RREFGGSDGEVTErhNALAREASSLKRLAEEFRIAV 166

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4885657  192 FATTQtimqkASSSSEEPSHASRrlCDVdidyrPYLCKAWQQLVKHRMFFSkQDDSQSSNQFSLVSRCL 260
Cdd:cd19493 167 LVTNQ-----ATTHFGDAGDGSS--GVT-----AALGDAWAHAVNTRLRLE-RCLLQLRRVLEIVKSPL 222
Rad51_DMC1_archRadA cd01123
recombinase Rad51, DMC1, and archaeal RadA; This group of recombinases includes the eukaryotic ...
 41-200 1.35e-15

recombinase Rad51, DMC1, and archaeal RadA; This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal protein RadA. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a similar recombination reaction as RecA, using ATP-dependent DNA binding activity and a DNA-dependent ATPase. However, this reaction is less efficient and requires accessory proteins such as RAD55/57 .


Pssm-ID: 410868 [Multi-domain]  Cd Length: 234  Bit Score: 74.10  E-value: 1.35e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885657   41 GDILEFHGPEGTGKTEMLYHLTARCILPKSEGGLEVEVLFIDTDYHFDMLRLVTILEHRLSQSSEEIIKYCLGRFFlvyc 120
Cdd:cd01123  19 GSITEMFGEFRTGKTQLCHTLAVTCQLPIDRGGGEGKAIYIDTEGTFRPERLRAIAQRFGLDPDDVLDNVAYARAF---- 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885657  121 sSSTHLLLTLYSLESMFCSHPsLCLLILDSLSAFYWIDRVNGGESVNLQEStLRKCSQCLEKLVNDYRLVLFATTQTIMQ 200
Cdd:cd01123  95 -NSDHQTQLLDQAAAMMVESR-FKLLIVDSATALYRTDYSGRGELSARQMH-LAKFLRMLQRLADEFGVAVVVTNQVVAQ 171
archRadA cd19515
archaeal recombinase Rad51/RadA; This group includes the archaeal protein RadA which is a ...
 43-196 3.90e-13

archaeal recombinase Rad51/RadA; This group includes the archaeal protein RadA which is a homolog of Rad51. RAD51 recombinase plays an essential role in DNA repair by homologous recombination (HR)


Pssm-ID: 410923 [Multi-domain]  Cd Length: 233  Bit Score: 67.00  E-value: 3.90e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885657   43 ILEFHGPEGTGKTEMLYHLTARCILPKSEGGLEVEVLFIDTDYHFDMLRLVTILEHRlSQSSEEIIKyclgRFFLVYCSS 122
Cdd:cd19515  21 ITEVFGEFGSGKTQLCHQLAVNVQLPPEEGGLNGKAVYIDTENTFRPERIMQMAKAL-GLDPDEVLD----NIYVARAYN 95

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 4885657  123 STHLLLTLYSLESMFCSHPSLCLLILDSLSAFYWIDRVnGGESVNLQESTLRKCSQCLEKLVNDYRLVLFATTQ 196
Cdd:cd19515  96 SNHQMLLVEKAEDLIKEGNNIKLLIVDSLTSHFRAEYV-GRGTLAERQQKLNKHLHDLHRLADLYNIAVLVTNQ 168
Rad51C cd19492
RAD51C recombinase; RAD51C recombinase, a RAD51 paralog, plays an important role in DNA repair ...
 41-246 1.94e-12

RAD51C recombinase; RAD51C recombinase, a RAD51 paralog, plays an important role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. RAD51C, together with the other RAD51 paralogs, RAD51B, RAD51D, XRCC3, and XRCC2, helps recruit RAD51 to the break site. Additionally, RAD51C acts as a mediator in the early steps of DNA damage signaling.


Pssm-ID: 410900 [Multi-domain]  Cd Length: 172  Bit Score: 64.17  E-value: 1.94e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885657   41 GDILEFHGPEGTGKTEMLYHLTARCILPKSEGGLEVEVLFIDTDYHFdmlrlvtilehrlsqsseeiikyclgRFFLVYC 120
Cdd:cd19492   1 GKITEICGVPGVGKTQLCMQLAVNVQIPKCFGGLAGEAIYIDTEGSF--------------------------NIHYFRV 54

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885657  121 SSSTHLLLTLYSLESMFCSHPSLCLLILDSLS-AFYwidrvnggesVNLQESTLRK-----CSQCLEKLVNDYRLVLFAT 194
Cdd:cd19492  55 HDYVELLALINSLPKFLEDHPKVKLIVVDSIAfPFR----------HDFDDLAQRTrllngLAQLLHSLARQHNLAVVLT 124

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....
gi 4885657  195 TQ--TIMQKASSSSEEpshasrrlcdvdidyrPYLCKAWQQLVKHRMFFSKQDD 246
Cdd:cd19492 125 NQvtTKISEDGQSQLV----------------PALGESWSHACTTRLFLTWDEK 162
Rad51 pfam08423
Rad51; Rad51 is a DNA repair and recombination protein and is a homolog of the bacterial ...
 41-206 5.62e-12

Rad51; Rad51 is a DNA repair and recombination protein and is a homolog of the bacterial ATPase RecA protein.


Pssm-ID: 462471 [Multi-domain]  Cd Length: 255  Bit Score: 64.25  E-value: 5.62e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885657     41 GDILEFHGPEGTGKTEMLYHLTARCILPKSEGGLEVEVLFIDTDYHFDMLRLVTILEhRLSQSSEEIIKYCLG-RFFlvy 119
Cdd:pfam08423  37 GSITEIFGEFRTGKTQLCHTLCVTCQLPLEMGGGEGKALYIDTEGTFRPERLVAIAE-RYGLDPEDVLDNVAYaRAY--- 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885657    120 csSSTHLLLTLYSLESMFCSHPsLCLLILDSLSAFYWIDRVNGGEsVNLQESTLRKCSQCLEKLVNDYRLVLFATTQTIM 199
Cdd:pfam08423 113 --NSEHQMQLLQQAAAMMSESR-FALLIVDSATALYRTDFSGRGE-LAERQQHLAKFLRTLQRLADEFGVAVVITNQVVA 188


                  ....*..
gi 4885657    200 QKASSSS 206
Cdd:pfam08423 189 QVDGAAG 195
Rad51D cd19489
RAD51D recombinase; RAD51D recombinase, a RAD51 paralog, plays an important role in DNA repair ...
 41-257 1.47e-10

RAD51D recombinase; RAD51D recombinase, a RAD51 paralog, plays an important role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. RAD51D, together with the other RAD51 paralogs, RAD51B, RAD51C, XRCC3, and XRCC2, helps recruit RAD51 to the break site.


Pssm-ID: 410897 [Multi-domain]  Cd Length: 209  Bit Score: 59.57  E-value: 1.47e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885657   41 GDILEFHGPEGTGKTEMLYHLTARCILPKSEGgleveVLFIDTDYHFDMLRLVTILEHRlSQSSEEIIKYcLGRFFLVYC 120
Cdd:cd19489   7 GEITELVGESSSGKTQLCLTAAANVASRSGQN-----VLYIDTKSSFSARRLAQILKSR-AQDAEEIDKA-LQRIRVVRV 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885657  121 SSSTHLLLTLYSLESMFcSHP------SLCLLILDSLSAFywIDRVNGGESVNLQESTLRKCSQCLEKLVNDYRLVLFAT 194
Cdd:cd19489  80 FDPYELLDLLEELRNTL-SQQqenlysRLKLVIIDSLSAL--ISPLLGGSKHSEGHALLASLARLLKKLAAEYQIAVLVT 156

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4885657  195 TQTImqKASSSSEEPSHasrrlcdvdidyRPYLCKAWQQLVKHRMFFSKQDDSQSSNQFSLVS 257
Cdd:cd19489 157 NLTV--RGGDGGQQGST------------KPALGEYWESVPSTRLLLSRDENDPEESGVCTAT 205
recomb_radA TIGR02236
DNA repair and recombination protein RadA; This family consists exclusively of archaeal RadA ...
 9-196 2.35e-10

DNA repair and recombination protein RadA; This family consists exclusively of archaeal RadA protein, a homolog of bacterial RecA (TIGR02012), eukaryotic RAD51 (TIGR02239), and archaeal RadB (TIGR02237). This protein is involved in DNA repair and recombination. The member from Pyrococcus horikoshii contains an intein. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 131290 [Multi-domain]  Cd Length: 310  Bit Score: 60.14  E-value: 2.35e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885657      9 ESGTELLARlegRSSLKEIEPNLfADEDSPVHG-----DILEFHGPEGTGKTEMLYHLTARCILPKSEGGLEVEVLFIDT 83
Cdd:TIGR02236  62 ETADDVLER---RKTIGKITTGS-KELDELLGGgietqAITEVFGEFGSGKTQICHQLAVNVQLPEEKGGLGGKAVYIDT 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885657     84 DYHFDMLRLVTILEHRLSQSSEEIIKYCLGRFFlvycsSSTHLLLTLYSLESMFCSH-PSLCLLILDSLSAFYWIDRVNG 162
Cdd:TIGR02236 138 ENTFRPERIMQMAEARGLDPDEVLKNIYVARAY-----NSNHQMLLVEKAEDLIKELnNPVKLLIVDSLTSHFRAEYVGR 212

                         170       180       190
                  ....*....|....*....|....*....|....
gi 4885657    163 GESVNLQEStLRKCSQCLEKLVNDYRLVLFATTQ 196
Cdd:TIGR02236 213 GALAERQQK-LNKHLHDLLRLADLYNAAVVVTNQ 245
XRCC3 cd19491
XRCC3 recombinase; XRCC3 (X-ray repair complementing defective repair in Chinese hamster cells ...
 41-261 5.04e-10

XRCC3 recombinase; XRCC3 (X-ray repair complementing defective repair in Chinese hamster cells 3) recombinase, a RAD51 paralog, plays an important role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. XRCC3, together with the other RAD51 paralogs, RAD51B, RAD51C, RAD51D, and XRCC2, helps recruit RAD51 to the break site.


Pssm-ID: 410899 [Multi-domain]  Cd Length: 250  Bit Score: 58.46  E-value: 5.04e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885657   41 GDILEFHGPEGTGKTEMLYHLTARCILPKSEGGLEVEVLFIDTDYHFDMLRLVTILEHRLSQSSEEIIKYCLGRFFLVYC 120
Cdd:cd19491  12 GGITEIAGESGAGKTQLCLQLALTVQLPRELGGLGGGAVYICTESSFPSKRLQQLASSLPKRYHLEKAKNFLDNIFVEHV 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885657  121 SSSTHLLLTLYSLESMFCSHPSLCLLILDSLSAFY----WIDRVNGGESVNLqestLRKCSQCLEKLVNDYRL-VLFAT- 194
Cdd:cd19491  92 ADLETLEHCLNYQLPALLERGPIRLVVIDSIAALFrsefDTSRSDLVERAKY----LRRLADHLKRLADKYNLaVVVVNq 167

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 4885657  195 ------TQTIMQKASSSSEEPSHASRRLCDVDIDYRPYLCKAWQQLVKHRMFFSKQDDS-QSSNQFSLVSRCLK 261
Cdd:cd19491 168 vtdrfdSSSDASGLGVLDYLSQFSSFSGGVSGNRKVPALGLTWANLVNTRLMLSRTPKRiTDSSAASISVRRLE 241
PTZ00035 PTZ00035
Rad51 protein; Provisional
 41-206 5.90e-10

Rad51 protein; Provisional


Pssm-ID: 185407 [Multi-domain]  Cd Length: 337  Bit Score: 58.86  E-value: 5.90e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885657    41 GDILEFHGPEGTGKTEMLYHLTARCILPKSEGGLEVEVLFIDTDYHFDMLRLVTILEhRLSQSSEEiikyCLGRFFLVYC 120
Cdd:PTZ00035 118 GSITELFGEFRTGKTQLCHTLCVTCQLPIEQGGGEGKVLYIDTEGTFRPERIVQIAE-RFGLDPED----VLDNIAYARA 192

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885657   121 SSSTHLLLTLYSLESMFCSHPsLCLLILDSLSAFYWIDRVNGGESVNLQEStLRKCSQCLEKLVNDYRLVLFATTQTIMQ 200
Cdd:PTZ00035 193 YNHEHQMQLLSQAAAKMAEER-FALLIVDSATALFRVDYSGRGELAERQQH-LGKFLRALQKLADEFNVAVVITNQVMAD 270


                 ....*.
gi 4885657   201 KASSSS 206
Cdd:PTZ00035 271 VDGASM 276
Rad51 cd19513
RAD51D recombinase; RAD51 recombinase plays an essential role in DNA repair by homologous ...
 41-200 4.51e-09

RAD51D recombinase; RAD51 recombinase plays an essential role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. RAD51 is recruited to the break site with the help of its paralogs, RAD51D, RAD51B, RAD51C, XRCC3, and XRCC2, where it forms long helical polymers which wrap around the ssDNA tail at the break which leads to pairing and strand invasion.


Pssm-ID: 410921 [Multi-domain]  Cd Length: 235  Bit Score: 55.40  E-value: 4.51e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885657   41 GDILEFHGPEGTGKTEMLYHLTARCILPKSEGGLEVEVLFIDTDYHFDMLRLVTILEhRLSQSSEEI---IKYclGRFFl 117
Cdd:cd19513  19 GSITELFGEFRTGKTQLCHTLAVTCQLPIDQGGGEGKALYIDTEGTFRPERLLAIAE-RYGLNGEDVldnVAY--ARAY- 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885657  118 vycsSSTHLLLTLYSLESMFCSHpSLCLLILDSLSAFYWIDRVNGGESVNLQeSTLRKCSQCLEKLVNDYRLVLFATTQT 197
Cdd:cd19513  95 ----NTDHQMQLLIQASAMMAES-RYALLIVDSATALYRTDYSGRGELSARQ-MHLAKFLRMLQRLADEFGVAVVITNQV 168


                ...
gi 4885657  198 IMQ 200
Cdd:cd19513 169 VAQ 171
recomb_RAD51 TIGR02239
DNA repair protein RAD51; This eukaryotic sequence family consists of RAD51, a protein ...
 41-200 5.54e-09

DNA repair protein RAD51; This eukaryotic sequence family consists of RAD51, a protein involved in DNA homologous recombination and repair. It is similar in sequence the exclusively meiotic recombinase DMC1 (TIGR02238), to archaeal families RadA (TIGR02236) and RadB (TIGR02237), and to bacterial RecA (TIGR02012).


Pssm-ID: 274048 [Multi-domain]  Cd Length: 316  Bit Score: 55.89  E-value: 5.54e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885657     41 GDILEFHGPEGTGKTEMLYHLTARCILPKSEGGLEVEVLFIDTDYHFDMLRLVTILEhRLSQSSEEI---IKYclGRFFl 117
Cdd:TIGR02239  96 GSITEIFGEFRTGKTQLCHTLAVTCQLPIDQGGGEGKALYIDTEGTFRPERLLAIAE-RYGLNPEDVldnVAY--ARAY- 171

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885657    118 vycsSSTHLLLTLYSLESMFcSHPSLCLLILDSLSAFYWIDRVNGGESVNLQEStLRKCSQCLEKLVNDYRLVLFATTQT 197
Cdd:TIGR02239 172 ----NTDHQLQLLQQAAAMM-SESRFALLIVDSATALYRTDFSGRGELSARQMH-LARFLRSLQRLADEFGVAVVITNQV 245


                  ...
gi 4885657    198 IMQ 200
Cdd:TIGR02239 246 VAQ 248
DMC1 cd19514
homologous-pairing protein DMC1; DMC1 has a central role in homologous recombination in ...
 43-196 8.36e-09

homologous-pairing protein DMC1; DMC1 has a central role in homologous recombination in meiosis. It assembles at the sites of programmed DNA double-strand breaks and carries out a search for allelic DNA sequences located on homologous chromatids. It forms octameric rings.


Pssm-ID: 410922 [Multi-domain]  Cd Length: 236  Bit Score: 54.67  E-value: 8.36e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885657   43 ILEFHGPEGTGKTEMLYHLTARCILPKSEGGLEVEVLFIDTDYHFDMLRLVTILEhRLSQSSEEiikyCLGRFFLVYCSS 122
Cdd:cd19514  21 ITEVFGEFRTGKTQLSHTLCVTAQLPGSMGGGGGKVAYIDTEGTFRPDRIRPIAE-RFGVDHDA----VLDNILYARAYT 95

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 4885657  123 STHLLLTLYSLESMFCSHPSLCLLILDSLSAFYWIDRVNGGESVNLQEsTLRKCSQCLEKLVNDYRLVLFATTQ 196
Cdd:cd19514  96 SEHQMELLDYVAAKFHEEAVFRLLIIDSIMALFRVDFSGRGELAERQQ-KLAQMLSRLQKISEEYNVAVFITNQ 168
PLN03186 PLN03186
DNA repair protein RAD51 homolog; Provisional
 41-200 9.84e-08

DNA repair protein RAD51 homolog; Provisional


Pssm-ID: 178728 [Multi-domain]  Cd Length: 342  Bit Score: 52.43  E-value: 9.84e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885657    41 GDILEFHGPEGTGKTEMLYHLTARCILPKSEGGLEVEVLFIDTDYHFDMLRLVTILEhRLSQSSEEIikycLGRFFLVYC 120
Cdd:PLN03186 123 GSITEIYGEFRTGKTQLCHTLCVTCQLPLDQGGGEGKAMYIDTEGTFRPQRLIQIAE-RFGLNGADV----LENVAYARA 197

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885657   121 SSSTHLLLTLYSLESMFcSHPSLCLLILDSLSAFYWIDRVNGGEsVNLQESTLRKCSQCLEKLVNDYRLVLFATTQTIMQ 200
Cdd:PLN03186 198 YNTDHQSELLLEAASMM-AETRFALMIVDSATALYRTEFSGRGE-LSARQMHLGKFLRSLQRLADEFGVAVVITNQVVAQ 275
radA PRK04301
DNA repair and recombination protein RadA; Validated
 43-196 1.94e-07

DNA repair and recombination protein RadA; Validated


Pssm-ID: 235273 [Multi-domain]  Cd Length: 317  Bit Score: 51.42  E-value: 1.94e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885657    43 ILEFHGPEGTGKTEMLYHLTARCILPKSEGGLEVEVLFIDTDYHFDMLRLVTILEHRlsqssEEIIKYCLGRFFLVYCSS 122
Cdd:PRK04301 104 ITEFYGEFGSGKTQICHQLAVNVQLPEEKGGLEGKAVYIDTEGTFRPERIEQMAEAL-----GLDPDEVLDNIHVARAYN 178

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 4885657   123 STHLLLTLYSLESMFCSHPSLCLLILDSLSAFYWIDRVNGGESVNLQESTLRKCSQcLEKLVNDYRLVLFATTQ 196
Cdd:PRK04301 179 SDHQMLLAEKAEELIKEGENIKLVIVDSLTAHFRAEYVGRGNLAERQQKLNKHLHD-LLRLADLYNAAVVVTNQ 251
recomb_DMC1 TIGR02238
meiotic recombinase Dmc1; This model describes DMC1, a subfamily of a larger family of DNA ...
 43-198 2.12e-07

meiotic recombinase Dmc1; This model describes DMC1, a subfamily of a larger family of DNA repair and recombination proteins. It is eukaryotic only and most closely related to eukaryotic RAD51. It also resembles archaeal RadA (TIGR02236) and RadB (TIGR02237) and bacterial RecA (TIGR02012). It has been characterized for human as a recombinase active only in meiosis.


Pssm-ID: 131292 [Multi-domain]  Cd Length: 313  Bit Score: 51.32  E-value: 2.12e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885657     43 ILEFHGPEGTGKTEMLYHLTARCILPKSEGGLEVEVLFIDTDYHFDMLRLVTILEhRLSQSSEEiikyCLGRFFLVYCSS 122
Cdd:TIGR02238  98 ITEVFGEFRCGKTQLSHTLCVTAQLPREMGGGNGKVAYIDTEGTFRPDRIRAIAE-RFGVDPDA----VLDNILYARAYT 172

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4885657    123 STHLLLTLYSLESMFCSHPsLCLLILDSLSAFYWIDRVNGGESVNLQESTLRKCSQcLEKLVNDYRLVLFATTQTI 198
Cdd:TIGR02238 173 SEHQMELLDYLAAKFSEEP-FRLLIVDSIMALFRVDFSGRGELSERQQKLAQMLSR-LNKISEEFNVAVFVTNQVQ 246
PLN03187 PLN03187
meiotic recombination protein DMC1 homolog; Provisional
 43-198 1.39e-06

meiotic recombination protein DMC1 homolog; Provisional


Pssm-ID: 215620 [Multi-domain]  Cd Length: 344  Bit Score: 49.01  E-value: 1.39e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885657    43 ILEFHGPEGTGKTEMLYHLTARCILPKSEGGLEVEVLFIDTDYHFDMLRLVTILEhRLSQSSEEIikycLGRFFLVYCSS 122
Cdd:PLN03187 128 ITEAFGEFRSGKTQLAHTLCVTTQLPTEMGGGNGKVAYIDTEGTFRPDRIVPIAE-RFGMDADAV----LDNIIYARAYT 202

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4885657   123 STHLLLTLYSLESMFCSHPsLCLLILDSLSAFYWIDRVNGGESVNLQESTLRKCSQcLEKLVNDYRLVLFATTQTI 198
Cdd:PLN03187 203 YEHQYNLLLGLAAKMAEEP-FRLLIVDSVIALFRVDFTGRGELAERQQKLAQMLSR-LTKIAEEFNVAVYMTNQVI 276
archRadB cd01394
archaeal RadB; The archaeal protein RadB shares similarity RadA, the archaeal functional ...
 41-164 1.10e-03

archaeal RadB; The archaeal protein RadB shares similarity RadA, the archaeal functional homologue to the bacterial RecA. The precise function of RadB is unclear.


Pssm-ID: 410882 [Multi-domain]  Cd Length: 216  Bit Score: 39.22  E-value: 1.10e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885657   41 GDILEFHGPEGTGKTEMLyhLTARCILPKSEGGleveVLFIDTDyhfdmlrlvTILEHRLSQSSEEIIKYCLGRFFLVYC 120
Cdd:cd01394  19 GTITQIYGPPGSGKTNIC--LQLAVEAAKQGKK----VVYIDTE---------GLSPERFQQIAGERFESIASNIIVFEP 83

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 4885657  121 SSSTHLLLTLYSLESMFCSHpSLCLLILDSLSAFYWIDRVNGGE 164
Cdd:cd01394  84 YSFDEQGVAIQEAEKLLKSD-KVDLVVVDSATALYRLELGDDSE 126
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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