|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
40-481 |
6.03e-165 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 471.72 E-value: 6.03e-165
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 40 ALILQLCNFSIYTQQMNLSIAIPAMVNNTAPPSQPNASTerpstdsqgywneTLKEFKAMAPAYDWSPEIQGIILSSLNY 119
Cdd:cd17318 1 AILLFLGFAVVYAMRVNLSVAIVAMVNSTATHDNNNTST-------------DKDTLPVEAPEFDWSEKTQGIILSSFFY 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 120 GSFLAPIPSGYVAGIFGAKYVVGAGLFISSFLTLFIPLAANAGVALLIVLRIVQGIAQVMVLTGQYSIWVKWAPPLERSQ 199
Cdd:cd17318 68 GYILTQIPGGYLAEKYGAKRVLGYSILITALLTLLTPLAARGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSR 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 200 LTTIAGSGSMLGSFIVLLAGGLLCQTIGWPYVFYIFGGIGCACCPLWFPLIyddpvnhpfisagekryivcslaqqdcsp 279
Cdd:cd17318 148 LTSIAYSGSQFGTVIAMPLSGFLCESLGWPSIFYIFGGLGLLWCLLWFFLV----------------------------- 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 280 gwslpiramiksLPLWAILVSYFCEYWLFYTIMAYTPTYISSVLQANLRDSGILSALPFVVGCICIILGGLLADFLLSRK 359
Cdd:cd17318 199 ------------LPVWAIVVAHFGHNWGFYTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGGYLADWLRSRG 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 360 ILRLITIRKLFTAIGVLFPSVILVSLPWVRSSHSMTMTFLVLSSAISSFCESGALVNFLDIAPRYTGFLKGLLQVFAHIA 439
Cdd:cd17318 267 ILSTTTVRKLFTSIGFLGPGVFLIALGYLGSNATLAVVFLTLSVGLSGACYSGFLVNHLDLAPNYAGTLMGITNTAATIA 346
|
410 420 430 440
....*....|....*....|....*....|....*....|...
gi 4885441 440 GAISPTAAGFFISQD-SEFGWRNVFLLSAAVNISGLVFYLIFG 481
Cdd:cd17318 347 GIISPLIVGAIVKNDqTIGQWRIVFFISAAIYILGAIFYLIFG 389
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
30-491 |
3.38e-137 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 403.74 E-value: 3.38e-137
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 30 KGFCSVRHGLALILQLCNFSIYTQQMNLSIAIPAMVNNTAPPSQPNASTERPSTDSQGywnetlkefkamaPAYDWSPEI 109
Cdd:TIGR00894 11 PYFCSFRLFLSFLLHICNVIIIAQRICLSLTMVAMVNKENSTDLACLSAENELDNIKN-------------PNFKWSGAL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 110 QGIILSSLNYGSFLAPIPSGYVAGIFGAKYVVGAGLFISSFLTLFIPLAANAGVALLIVLRIVQGIAQVMVLTGQYSIWV 189
Cdd:TIGR00894 78 QGLILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAAGGGIALVVFCRVIQGLAQGSVSPATHKIIV 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 190 KWAPPLERSQLTTIAGSGSMLGSFIVLLAGGLLCQT-IGWPYVFYIFGGIGCACCPLWFPLIYDDPVNHPFISAGEKRYI 268
Cdd:TIGR00894 158 KWAPPKERSRLLGMSTSGFQLGTFIFLPISGWLCESwGGWPMIFYVFGIVGCAWSLLWFVFPADDPSIHPCISKFEKKYI 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 269 VCSLAQQDCSPGWSLPIRAMIKSLPLWAILVSYFCEYWLFYTIMAYTPTYISSVLQANLRDSGILSALPFVVGCICIILG 348
Cdd:TIGR00894 238 NSSLQGQKGSTRQSLPIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLLSSLPYLFAWLCSIFA 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 349 GLLADFLLSRKILRLITIRKLFTAIGVLFPSVILVSLPWVRSSHSMTMTFLVLSSAISSFCESGALVNFLDIAPRYTGFL 428
Cdd:TIGR00894 318 GYLADFLKSSKTLSLTAARKIFNGIGGLGPGIFAYALPYLSAAFYLTIIILTLANAVSSGPLAGVLINSLDLAPRFLGFI 397
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4885441 429 KGLLQVFAHIAGAISPTAAGFFISQDSEFGWRNVFLLSAAVNISGLVFYLIFGRADVQDWAKE 491
Cdd:TIGR00894 398 KGITGLPGFIGGLIASTLAGNILSQDSKNVWLIVFLIMAFVNILCVIFYLIFGSAERQDWAKE 460
|
|
| MFS_SLC17A5 |
cd17381 |
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ... |
39-481 |
1.49e-102 |
|
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340939 [Multi-domain] Cd Length: 397 Bit Score: 312.87 E-value: 1.49e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 39 LALILQLCNFSIYTQQMNLSIAIPAMVNNTAPPSQPNAST--ERPSTDSQGYWNETlkefkamAPAYDWSPEIQGIILSS 116
Cdd:cd17381 1 LALLAFFGFFVVYALRVNLSVALVDMVNSNSTLPSNNSSNacPEHSSSPSVEHNET-------GKKYDWDAETQGWILGS 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 117 LNYGSFLAPIPSGYVAGIFGAKYVVGAGLFISSFLTLFIPLAANAGVALLIVLRIVQGIAQVMVLTGQYSIWVKWAPPLE 196
Cdd:cd17381 74 FFYGYIITQIPGGYLASKIGGKLLLGFGILGTAVFTLLTPLAADLGAGYLIAVRALEGLGEGVTFPAMHAMWASWAPPLE 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 197 RSQLTTIAGSGSMLGSFIVLLAGGLLCQTIGWPYVFYIFGGIGCaccpLWFPLiyddpvnhpfisagekryivcslaqqd 276
Cdd:cd17381 154 RSRLLTISYAGAQLGTVVSLPLSGLICYYLDWTYVFYIFGAVGL----LWFFL--------------------------- 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 277 cspgWslpiraMIKSLPLWAILVSYFCEYWLFYTIMAYTPTYISSVLQANLRDSGILSALPFVVGCICIILGGLLADFLL 356
Cdd:cd17381 203 ----W------IWLVMPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFDIQENGFLSALPYLGCWLFMILSGQIADNLR 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 357 SRKILRLITIRKLFTAIGVLFPSVILVSLPWVRSSHSMTMTFLVLSSAISSFCESGALVNFLDIAPRYTGFLKGLLQVFA 436
Cdd:cd17381 273 EKQNFSTVCVRKIFTLIGMIGPAVFLLAAGFTGCNYSLAVAFLTISSTLGGFSASGFNINHLDIAPSYAGILLGITNTFA 352
|
410 420 430 440
....*....|....*....|....*....|....*....|....*
gi 4885441 437 HIAGAISPTAAGFFISQDSEFGWRNVFLLSAAVNISGLVFYLIFG 481
Cdd:cd17381 353 TIPGMVGPVIAKSLTHNNTVEEWQTVFYISAAINVFGAIFFTIFG 397
|
|
| MFS_SLC17A6_7_8_VGluT |
cd17382 |
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ... |
56-481 |
3.44e-78 |
|
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340940 [Multi-domain] Cd Length: 380 Bit Score: 249.18 E-value: 3.44e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 56 NLSIAIPAMVNNTAPPSQPNASTERPStdsqgywnetlkefkamapaYDWSPEIQGIILSSLNYGSFLAPIPSGYVAGIF 135
Cdd:cd17382 17 NLGVAIVRMVNNFTDAYGGKVIVHKAE--------------------FNWTPETVGLIESSFFWGYLVTQIPGGFIAAKF 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 136 GAKYVVGAGLFISSFLTLFIPLAANAGVALLIVLRIVQGIAQVMVLTGQYSIWVKWAPPLERSQLTTIAGSGSMLGSFIV 215
Cdd:cd17382 77 AANRVFGLAIFVTSTLNMLIPIAARVHYGCVIFVRILQGLVEGVTYPACHGIWRKWAPPLERSRLATTAFCGSYAGAVVG 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 216 LLAGGLLCQTIGWPYVFYIFGGIGCaccpLWFPliyddpvnhpfisagekryivcslaqqdcspGWslpiraMIKSLPLW 295
Cdd:cd17382 157 MPLSGILVQYVGWSSPFYVYGVFGI----IWYM-------------------------------FW------MLVSMPVY 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 296 AILVSYFCEYWLFYTIMAYTPTYISSVLQANLRDSGILSALPFVVGCICIILGGLLADFLLSRKILRLITIRKLFTAIGV 375
Cdd:cd17382 196 AIIVANFCRSWTFYLLLISQPAYFKEVFGFDISKVGILSALPHLVMTIIVPIGGQLADYLRSRGILSTTAVRKIFNCGGF 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 376 LFPSVILVSLPWVRSShSMTMTFLVLSSAISSFCESGALVNFLDIAPRYTGFLKGLLQVFAHIAGAISPTAAGFFISQDS 455
Cdd:cd17382 276 GMEATFLLVVAFSHSP-TVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGIGTLSGMVCPVIVGALTKHKT 354
|
410 420
....*....|....*....|....*.
gi 4885441 456 EFGWRNVFLLSAAVNISGLVFYLIFG 481
Cdd:cd17382 355 REEWQYVFLIASLVHFFGVIFYAIFA 380
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
98-481 |
2.74e-69 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 225.51 E-value: 2.74e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 98 AMAPAYDWSPEIQGIILSSLNYGSFLAPIPSGYVAGIFGAKYVVGAGLFISSFLTLFIPLAANAGVALLIVLRIVQGIAQ 177
Cdd:cd17380 24 PMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLTPLLAYSSLPLLILSRILLGLGE 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 178 VMVLTGQYSIWVKWAPPLERSQLTTIAGSGSMLGSFIVLLAGGLLCQTIGWPYVFYIFGGIGCACCPLWFPLIyddpvnh 257
Cdd:cd17380 104 GVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYFFGLLGLLWALVWLIYL------- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 258 pfisagekryivcslaqqdcspgwslpiramiksLPLWAILVSYFCEYWLFYTIMAYTPTYISSVLqANLRDSGILSALP 337
Cdd:cd17380 177 ----------------------------------PPVWAIIVAHFCMNWGFYILLSWLPTYFHEVL-VPLAKGWVFNVVP 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 338 FVVGCICIILGGLLADFLLSRKIlRLITIRKLFTAIGVLFPSVILVSLPWVRSSHSMTMtFLVLSSAISSFCESGALVNF 417
Cdd:cd17380 222 WLVMFPSSNVAGWLADHLISRGW-TVTSVRKLMQSIGFLGPALFLLLLSHTDSFSLALL-CMSVALGLSAFSSSGVLVNH 299
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 4885441 418 LDIAPRYTGFLKGLLQVFAHIAGAISPTAAGFFISQDSEfgWRNVFLLSAAVNISGLVFYLIFG 481
Cdd:cd17380 300 QDIAPNYAGIVFGISNTAGTIPGIVGVYLTGYILEATGS--WSLVFVLAAVVNLVGAVVFLLFG 361
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
98-482 |
1.44e-32 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 127.68 E-value: 1.44e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 98 AMAPAYDWSPEIQGIILSSLNYGSFLAPIPSGYVAGIFGAKYVVGAGLFISSFLTLFIPLAANagVALLIVLRIVQGIAQ 177
Cdd:COG2271 35 PLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATS--FWQLLLLRFLLGLGE 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 178 VMVLTGQYSIWVKWAPPLERSQLTTIAGSGSMLGSFIVLLAGGLLCQTIGWPYVFYIFGGIGCACCPLWFpliyddpvnh 257
Cdd:COG2271 113 AGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLLLALLRF---------- 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 258 pfisagekryivcslaqqdcspgwslpiramikslplWAILVSYFCEYWLFYTIMAYTPTYISSVLQANLRDSGILSALP 337
Cdd:COG2271 183 -------------------------------------WLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLP 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 338 FVVGCICIILGGLLADFLLSRkilrlitiRKLFTAIGVLFPSVILVSLPWVrSSHSMTMTFLVLSSAISSFCESGALVNF 417
Cdd:COG2271 226 FLAGIVGSLLGGWLSDRLGRR--------RKLVLAIGLLLAALALLLLALL-PSPALAIALLFLAGFGLGGAFGLLWALA 296
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4885441 418 LDIAP-RYTGFLKGLLQVFAHIAGAISPTAAGFFISQdseFGWRNVFLLSAAVNISGLVFYLIFGR 482
Cdd:COG2271 297 AELFPkKARGTASGLVNTFGFLGGALGPLLVGYLLDA---TGYQAAFLLLAALALLAALLALLLLR 359
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
105-479 |
6.52e-29 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 117.29 E-value: 6.52e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 105 WSPEIQGIILSSLNYGSFLAPIPSGYVAGIFGAKYVVGAGLFISSFLTLFIPLAANagVALLIVLRIVQGIAQVMVLTGQ 184
Cdd:cd17319 35 LSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATS--LTSLYVLRFLLGVAEAGFFPGA 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 185 YSIWVKWAPPLERSQLTTIAGSGSMLGSFIVLLAGGLLCQTIGWPYVFYIFGGIGCACCPLWFPLIYDdpvnhpfisage 264
Cdd:cd17319 113 IKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYLRQ------------ 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 265 kryivcslaqqdcspgwslpiramikslpLWAILVSYFCEYWLFYTIMAYTPTYISSVLQANLRDSGILSALPFVVGCIC 344
Cdd:cd17319 181 -----------------------------VWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIG 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 345 IILGGLLADFLLSRKilrlitiRKLFTAIGVLFPSVILVSLPWVrSSHSMTMTFLVLSSAISSFCESGALVNFLDIAPR- 423
Cdd:cd17319 232 MILGGRLSDRLLRGA-------RRLVIIIGLLLAAVGLLLAYLT-TSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGe 303
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 4885441 424 YTGFLKGLLQVFAHIAGAISPTAAGFFIsqDSEFGWRNVFLLSAAVNISGLVFYLI 479
Cdd:cd17319 304 AAATAGGLINSGGNLGGFVAPLLIGYLV--DATGSYTAAFLFLAAVALLAALLVLL 357
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
98-444 |
1.17e-25 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 107.50 E-value: 1.17e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 98 AMAPAYDWSPEIQGIILSSLNYGSFLAPIPSGYVAGIFGAKYVVGAGLFISSFLTLFIPLAANagVALLIVLRIVQGIAQ 177
Cdd:pfam07690 22 LLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASS--LWLLLVLRVLQGLGA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 178 VMVLTGQYSIWVKWAPPLERSQLTTIAGSGSMLGSFIVLLAGGLLCQTIGWPYVFYIFGGIGCACCPLWFplIYDDPVNH 257
Cdd:pfam07690 100 GALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLL--LPRPPPES 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 258 PFISAGEKRYIVcslaqqdcspgWSLPIRAMIKSLPLWAILVSyFCEYWLFYTIMAYTPTYIsSVLQANLRDSGILSALP 337
Cdd:pfam07690 178 KRPKPAEEARLS-----------LIVAWKALLRDPVLWLLLAL-LLFGFAFFGLLTYLPLYQ-EVLGLSALLAGLLLGLG 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 338 FVVGCICIILGGLLADFLLSRKILRLITIRKLFTAIGVLFPSVILVSLpwvrsshsMTMTFLVLSSAISSFCESGALVNF 417
Cdd:pfam07690 245 GLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSL--------WLLLALLLLGFGFGLVFPALNALV 316
|
330 340
....*....|....*....|....*...
gi 4885441 418 LDIAP-RYTGFLKGLLQVFAHIAGAISP 444
Cdd:pfam07690 317 SDLAPkEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
102-478 |
9.62e-25 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 105.59 E-value: 9.62e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 102 AYDWSPEIQGIILSSLNYGSFLAPIPSGYVAGIFGAKYVVGAGLFISSFLTLFIPLAANagVALLIVLRIVQGIAQVMVL 181
Cdd:cd06174 25 SFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPS--FWLLLLGRFLLGLGSGLID 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 182 TGQYSIWVKWAPPLERSQLTTIAGSGSMLGSFIVLLAGGLLCQ--TIGWPYVFYIFGGIGCACCPLWFPLIYDDPVNHPF 259
Cdd:cd06174 103 PAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASslGFGWRAVFLIAAALALLAAILLLLVVPDPPESARA 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 260 ISAGEKryivcslaqqdcSPGWSLPIRAMIKSLPLWAILVSYFCEYWLFYTIMAYTPTYISSVLQANLRDSGILSALPFV 339
Cdd:cd06174 183 KNEEAS------------SKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGL 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 340 VGCICIILGGLLADFLLSRKILrlitirklfTAIGVLFPSVILVSLPWVRSSHSMTMTFLVLSSAISSFCESGALVNFLD 419
Cdd:cd06174 251 AGALGSLLLGLLSDRLIGRKPL---------LLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAEL 321
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 4885441 420 IAPRYTGFLKGLLQVFAHIAGAISPTAAGFFISQDseFGWRNVFLLSAAVNISGLVFYL 478
Cdd:cd06174 322 FPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAAT--FGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
111-480 |
5.51e-23 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 100.34 E-value: 5.51e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 111 GIILSSLNYGSFLAPIPSGYVAGIFGAKYVVGAGLFISSFLTLFIPLAANagVALLIVLRIVQGIAQVMVLTGQYSIWVK 190
Cdd:cd17325 34 GLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATS--YWQLLLARFLQGLASAAVWPAAMALIAD 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 191 WAPPLERSQLTTIAGSGSMLGSFIVLLAGGLLCQTIGWPYVFYIFGGIGCACCPLWFPLIYDDPVNHPfisagekryivc 270
Cdd:cd17325 112 IAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRPPPN------------ 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 271 slAQQDCSPGWSLPIRAMIKSLPLWAILVSYFCEYWLFYTIMAYTPTYISSVLQANLRDSGILSALPFVVGCICIILGGL 350
Cdd:cd17325 180 --KRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGK 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 351 LADfllsrKILRLITIRKLFTAIGVLFPSVILVSLPWvrsshsMTMTFLVLSSAISSFCESGALVNFLDIAPRYT-GFLK 429
Cdd:cd17325 258 LSD-----RIGRKPLILIGLLLSAVALLLLPLATSFW------LLLLLLALLGLGLGLVFPATLALLADIVPPEGrGTAM 326
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 4885441 430 GLLQVFAHIAGAISPTAAGFFISQdseFGWRNVFLLSAAVNISGLVFYLIF 480
Cdd:cd17325 327 GLFNTAFSLGMVLGPLLGGFLYDA---FGFATPFLAAAALLLLAAVLFLLL 374
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
97-482 |
2.86e-19 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 89.55 E-value: 2.86e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 97 KAMAPAYDWSPEIQGIILSSLNYGSFLAPIPSGYVAGIFGAKYVVGAGLFISSFLTLFIPLAANagVALLIVLRIVQGIA 176
Cdd:COG2223 29 PPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVS--YWLLLLLGLLLGIG 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 177 QVMVLTGQYSIWVKWAPPLERSQLTTIAGSGSMLGSFIVLLAGGLLCQTIGWPYVFYIFGGIGCACCPLWFPLIYDDPVN 256
Cdd:COG2223 107 GGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLRDPPAG 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 257 HPFISAGEKRyivcslaqqdcspgwslPIRAMIKSLPLWAILVSYFCEYWLFYTIMAYTPTYISSVLQANLRDSGILSAL 336
Cdd:COG2223 187 AAAAAKASLR-----------------DQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAAL 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 337 PFVVGCICIILGGLLADFLLSRKILRLITIrklFTAIGVLFPSVILVSLPWvrsshsmtmtFLVLSSAISSFCESGALVN 416
Cdd:COG2223 250 FALLGALGRPLGGWLSDRIGGRRVLLIVFA---LMALGLLLLALALGSLWL----------FLVLFLLLGLALGGGNGAV 316
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 417 FLDIA----PRYTGFLKGLLQVFAHIAGAISPTAAGFFIsqDSEFGWRNVFLLSAAVNISGLVFYLIFGR 482
Cdd:COG2223 317 FALVPdifpTKNAGAVYGLVGAAGGLGGFLGPLLFGALL--DATGSYTAAFLVFAVLALVALVLTLLLYR 384
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
98-388 |
5.69e-19 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 88.11 E-value: 5.69e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 98 AMAPAYDWSPEIQGIILSSLNYGSFLAPIPSGYVAGIFGAKYVVGAGLFISSFLTLFIPLAANagVALLIVLRIVQGIAQ 177
Cdd:COG2814 35 LIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPS--LWLLLAARFLQGLGA 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 178 VMVLTGQYSIWVKWAPPLERSQLTTIAGSGSMLGSFIVLLAGGLLCQTIGWPYVFYIFGGIGCACCPLWFPLIyddPVNH 257
Cdd:COG2814 113 GALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLRLL---PESR 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 258 PFISAGEKRyivcslaqqdcspgwslPIRAMIKSLPLWAILVSYFCEYWLFYTIMAYTPTYISSVLQANLRDSGILSALP 337
Cdd:COG2814 190 PAARARLRG-----------------SLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALF 252
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 4885441 338 FVVGCICIILGGLLADFLLSRKILRLItirklFTAIGVLFPSVILVSLPWV 388
Cdd:COG2814 253 GLGGVLGALLAGRLADRFGRRRLLLIG-----LLLLALGLLLLALAGSLWL 298
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
111-478 |
2.61e-14 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 74.12 E-value: 2.61e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 111 GIILSSLNYGSFLAPIPSGYVAGIFGAKYVVGAGLFISSFLTLFIPLAANAGValLIVLRIVQGIAQVMVLTGQYSIWVK 190
Cdd:cd17324 37 GLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFAL--LLLARALAGLAHGGFWAIAAAYAAD 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 191 WAPPLERSQLTTIAGSGSMLGSFIVLLAGGLLCQTIGWPYVFYIFGGIGCACCPLWFPLIYDDPVNHPFisagekryivc 270
Cdd:cd17324 115 LVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPKKPG----------- 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 271 slaqqdcSPGWSLPIRAMIKSLPLWAILVSYFCEYWLFYTIMAYTPTYISSVLQANLRDSGILSALPFVVGCICIILGGL 350
Cdd:cd17324 184 -------SLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGR 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 351 LADFLLSRKILRLITirkLFTAIGVLFPsvILVSLPWVrsshsMTMTFLVLSSAISSfCESGALVNFLDIAPRYTGFLKG 430
Cdd:cd17324 257 LADRGGRRALLIALL---LLAAALLLLT--LLGPSPLL-----LLVGLVLWGLGFFA-AHSALQTRVLRLAPEARGLASS 325
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 4885441 431 LLQVFAHIAGAISPTAAGFFISQdseFGWRNVFLLSAAVNISGLVFYL 478
Cdd:cd17324 326 LYLAAYNLGGALGAALGGLVLDH---GGWAGVGWVGAALLLLALLLAL 370
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
111-463 |
2.50e-11 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 65.09 E-value: 2.50e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 111 GIILSSLNYGSFLAPIPSGYVAGIFGAKYVVGAGLFISSFLTLFipLAANAGVALLIVLRIVQGIAQVMVLTGQYSIWVK 190
Cdd:TIGR00881 33 GLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLF--FGFSTSLWVMAALWALNGIFQGMGWPPCGRTVTK 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 191 WAPPLERSQLTTIAGSGSML-GSFIVLLAGGLLCQTIGWPYVFYIFGGIGCACCPLWFPLIYDDPVNHPFISAGEKRYIV 269
Cdd:TIGR00881 111 WFSRSERGTWVSFWNCSHNVgGGLLPPLVLFGIAELYSWHWVFIVPGIIAIIVSLICFLLLRDSPQSCGLPPAEEMPNEE 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 270 CSLAQQDCSPG---WSLPIRAMIKSLPLWAILVSYFCEYWLFYTIMAYTPTYISSVLQANLRDSGILSALPFVVGCICII 346
Cdd:TIGR00881 191 PDGDAEKKEEEltkKQIFLQYVLLNKVLWYISLGYVFVYVVRTGILDWSPLYLTQEKGFSKEKASWAFTLYELGGLVGTL 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 347 LGGLLADFLLSRKILRLITIRKLFTAIGVLFPSVILVSLPWVRSSHSMTMTFLVLSSaISSFCesgalVNFLDIAP-RYT 425
Cdd:TIGR00881 271 LAGWLSDKLFNGRRGPLAVFFMALIIVSLLVYWLNPAANPLMDLICLFALGFLVYGP-QMLIG-----VIASELAPkKAA 344
|
330 340 350
....*....|....*....|....*....|....*...
gi 4885441 426 GFLKGLLQVFAHIAGAISPTAAGFFISQdseFGWRNVF 463
Cdd:TIGR00881 345 GTAAGFVGFFAYLGGILAGLPLGYLADG---FGWAGAF 379
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
126-387 |
2.02e-10 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 62.65 E-value: 2.02e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 126 IPSGYVAGIFGAKYVVGAGLFISSFLTLFIPLAANagVALLIVLRIVQGIAQVMVLTGQYSIWVKWAPPLERSQLTTI-- 203
Cdd:cd17327 59 LPGNLLLQRFPPSKWLSVFIVLWGLLTLLTAAVKN--FGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFfy 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 204 --AGSGSMLGSFI------VLLAGGLLcqtiGWPYVFYIFGGIGCAC---CPLWFPliyDDPVNHPFISAGEKRYIVCSL 272
Cdd:cd17327 137 aaAGLGSIFGGLLaygvfkILGVGGLA----GWRWLFIIEGLITIIIglvIFFWLP---DNPSKAWFLTEEEKELAVERL 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 273 AQQDCSPG-----WSLPIRAMiKSLPLWAILVSYFCEYWLFYTIMAYTPTYISS----VLQANLrdsgiLSALPFVVGCI 343
Cdd:cd17327 210 RANQTGKGdqkfkWKQIKEAF-KDPRTWLLFLFFFCSQITNNGISNFLPLILKSlgfySLQTNL-----LSVPIGALGAV 283
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 4885441 344 CIILGGLLADFLLSRKILRLITIrkLFTAIGvlfpSVILVSLPW 387
Cdd:cd17327 284 SLLIAALLSDRFKKRGLFAIFAC--VLALVG----SIILLAAPN 321
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
98-357 |
2.24e-10 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 61.75 E-value: 2.24e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 98 AMAPAYDWSPEIQGIILSSLNYGSFLAPIPSGYVAGIFGAKYVVGAGLFISSFLTLFIPLAANagVALLIVLRIVQGIAQ 177
Cdd:COG0477 39 SIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPS--PELLIAARALQGIGA 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 178 VMVLTGQYSIWVKWAPPLERSQLTTIAGSGSMLGSFIVLLAGGLLCQTIGWPYVFYIFGGIGCaccpLWFPLIYDDPVNH 257
Cdd:COG0477 117 GGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGL----LALVLRLRLPESR 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 258 PFISAGEKRYIVCSLAQQDCSPGWSLPIRAMIKSLPLWAILVSYFCEYWLFYTIMAYTPTYISSVLQANLRDSGILSALP 337
Cdd:COG0477 193 GLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLL 272
|
250 260
....*....|....*....|
gi 4885441 338 FVVGCICIILGGLLADFLLS 357
Cdd:COG0477 273 ALLLALLLLLLLLLLLLLLA 292
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
123-487 |
4.88e-10 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 61.43 E-value: 4.88e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 123 LAPIPSGYVAGIFGAKYVVGAGLFIssfLTLFIPLAANA-GVALLIVLRIVQGIAQVM---VLTGqysiWVKWAPPLERS 198
Cdd:COG2807 68 LFAPLAPRLARRFGLERTLLLALLL---LAAGLLLRSLApSVALLLAGTALIGAGIAVgnvLLPG----LIKRWFPDRVG 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 199 QLTTIAGSGSMLGSFIVLLAGGLLCQTIGWPYVFYIFGGIGCACCPLWFPLIYDDPVNHPfisagekryivcslaqqdcS 278
Cdd:COG2807 141 LMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPAAAA-------------------A 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 279 PGWSLPIRAMIKSLPLWAILVSYFCEYWLFYTIMAYTPTYISSvLQANLRDSGILSALPFVVGCICIILGGLLADFLLSR 358
Cdd:COG2807 202 APAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRD-AGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDR 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 359 KILRLITIrkLFTAIGVLFPSVILVSLPWVrsshsmtmtFLVLSSAISSFCESGALVNFLDIA--PRYTGFLKGLLQVFA 436
Cdd:COG2807 281 RPLLLLLG--LLGLAGLLGLLLAPGSLPWL---------WAVLLGLGQGGLFPLALTLIGLRArtPAEAAALSGMAQSVG 349
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 4885441 437 HIAGAISPTAAGFFISQDSefGWRNVFLLSAAVNISGLVFYLIFGRADVQD 487
Cdd:COG2807 350 YLLAALGPLLVGALHDATG--SWTAALLLLAALAVLMLVAGLLAGRPYVED 398
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
140-452 |
2.69e-09 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 59.15 E-value: 2.69e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 140 VVGAGLFISSFLTLFI--PLAANAGVALLIVLRIVQGIAQVMVLTGQYSiwvkWAP-----PLERSQLTTIAGSGSMLGS 212
Cdd:COG2211 85 LIGAIPLALSFVLLFTapDLSPTGKLIYALVTYLLLGLAYTLVNIPYSA----LGAeltpdYEERTRLSSWRFAFAGLGG 160
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 213 FIVLLAGGLL------CQTIGWPYVFYIFGGIGCACcpLWFPliyddpvnhpFISAGEKRYIVCSlaqqdcspgwSLPIR 286
Cdd:COG2211 161 LLASVLPPPLvaafggDAALGYRLTALIFAVLGLLA--FLLT----------FFGTKERPVPEEE----------KVSLK 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 287 AMIKSL----PLWAILVSYFCeYWLFYTIM-AYTPTYISSVLQANLRDSGILSALPFVVGCICIILGGLLADFLLSRKIL 361
Cdd:COG2211 219 ESLKALlknrPFLLLLLAYLL-FFLALALVaALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAF 297
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 362 RlitirklftaIGVLFPSVILVSLPWVRSSHsmtMTFLVLSSAISSFCESGALVNFL----DIAP--------RYTGFLK 429
Cdd:COG2211 298 I----------IGLLLAALGLLLLFFLGPGN---LWLLLVLAALAGIGLGAILVLPWamlaDVVDydewktgrRREGLYF 364
|
330 340
....*....|....*....|...
gi 4885441 430 GLLQVFAHIAGAISPTAAGFFIS 452
Cdd:COG2211 365 GIFTFAIKLGQALAGALAGLLLA 387
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
120-480 |
1.09e-08 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 56.81 E-value: 1.09e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 120 GSFLAPIpSGYVAGIFGAKYVVGAGLFISSFLTLFIPLAANagVALLIVLRIVQGI------AQVMVLTGQYSiwvkwaP 193
Cdd:cd17474 47 AAVLMPV-AGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDS--FALLLAGRALQGIgaaglgPLALTLIGDLF------E 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 194 PLERSQLttIAGSGSMLGSFIVL--LAGGLLCqTIGWPYVFYIFGgigcACCPLWFpLIYDDPVNHPFISAGEKRYIVcs 271
Cdd:cd17474 118 GGERAKA--MGLYEAALGLGIAVgpLLGGLLA-AISWRYPFFLLA----ALIPVAF-LAILFLLPEPKEKAKSSSATK-- 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 272 laqqdcspgwslpIRAMIKSL---PLWAILVSYFCEYWLFYTIMAYTPTYISSVLQANLRDSGILSALPFVVGCI-CIIL 347
Cdd:cd17474 188 -------------LRDLKKALrgrGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALgSLFV 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 348 GGLLADFLLSRKILrlitirklftAIGVLFPSVILVSLPWVRSshsmtMTFLVLSSAISSFCESGALVNFLDIA-----P 422
Cdd:cd17474 255 GRLLKKRFGARRIL----------VIGLLLYALSLLLLGFVPS-----LALLLIAIVLFGLGLGLNLPLLTTLVtelapE 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 4885441 423 RYTGFLKGLLQVFAHIAGAISPTAAGFFIsqdSEFGWRNVFLLSAAVNISGLVFYLIF 480
Cdd:cd17474 320 EERGTASSLYNFVRFLGQAVGPLLFGLLL---EIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
106-478 |
1.94e-08 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 56.06 E-value: 1.94e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 106 SPEIQGIILSSLNYGSFLAPIPSGYVAGIFGAKYVVGAGLFISSFLTLFIPLAANagVALLIVLRIVQGIAQVMVLTGQY 185
Cdd:cd17489 29 SEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATS--VALLLVLRLIHGIGWGAFTTAAA 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 186 SIWVKWAPPLERSQLTTIAGSGSMLGSFIVLLAGGLLCQTIGWPYVFYIFGGIGCACCPLWFpLIYDDPVNHPFISAGEK 265
Cdd:cd17489 107 TLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVF-LVKDPPPVAAEEAEAGT 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 266 RyivcslaqqdcSPGWSLPIRAMIKSLPLWAILVSYFceywlfyTIMAYTPTYISSVLQANlrdsgilSALPFVVGCICI 345
Cdd:cd17489 186 R-----------AFRRLVEKKVLPPALILFLASIAYG-------AISTFLPLYAAERGISN-------AGLFFTVYAIAL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 346 ILGGLLADFLLSRKilrlitIRKLFTAIGVLFPSVILVSLpWVRSSHSMTMTFLVLSSAISSFCESGALVNFLDIAPRYT 425
Cdd:cd17489 241 LLSRPFSGKLSDRK------GPKTVIIPGLLLLALGLLLL-SFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHR 313
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 4885441 426 -GFLKGLLQVFAHIAGAISPTAAGFFIsqdSEFGWRNVFLLSAAVNISGLVFYL 478
Cdd:cd17489 314 rGAANGTFFIFFDLGIGLGGLLLGLVA---ELFGYRAMFLLAAVVVLLALVLYI 364
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
98-483 |
2.79e-08 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 55.63 E-value: 2.79e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 98 AMAPAYDWSPEIQGIILSSLNYGSFLAPIPSGYVAGIFGAKYVVGAGLFISSFLTLFIPLAANagVALLIVLRIVQGIAQ 177
Cdd:COG0738 33 ALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPS--YPLLLLALFLLGLGL 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 178 VMVLTGQYSIwVKWAPPLERSQLTTIAGSGSMLGSFIVLLAGGLLCQ---TIGWPYVFYIFGGIGCACCPLWFPLIYDDP 254
Cdd:COG0738 111 GLLDVAANPY-VAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILlglSLSWHLPYLILAVLLLLLALLFLRSKLPEI 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 255 VNHPFISAGEKRyivcslaqqdcspgwslPIRAMIKSLPLWAILVSYFCEYWLFYTIMAYTPTYISSVLQANLRDSGILS 334
Cdd:COG0738 190 EEEEEEAAGSAA-----------------SLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGL 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 335 ALPFVVGCICIILGGLLADFLLSRKILRLITIrklFTAIGVLFpsVILVSLPWVrsshsmTMTFLVLSSAISSFCESGAL 414
Cdd:COG0738 253 SLFWGGMTIGRFLGGFLLKRFGPVRLLRLSAL---LAAVGLLL--ALLAPGPWL------ALIGLALVGLGLSLMFPTIF 321
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4885441 415 VNFLDIAPRYTGFLKGLLQVFAHIAGAISPTAAGFFISQdseFGWRNVFLLSAAVNISGLVFYLIFGRA 483
Cdd:COG0738 322 SLALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADA---FGLRAAFLVPLVCYLLILLLALALKRK 387
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
123-478 |
6.21e-08 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 54.93 E-value: 6.21e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 123 LAPIPSGYVAGIFGAKYVVGAGLFISSFLTLFIPLAANagVALLIVLRIVQGIAQVMVLTGQYSIWVKWAPPLERSQLTT 202
Cdd:cd17328 49 VLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPN--FWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALG 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 203 IAGSGSMLGSFIVLLAGGLLCQ-TIGWPYVFYIFGGIGCACCPLWFPLIYDDPVNHPFISAGEKRYIvcslaqqdcsPGW 281
Cdd:cd17328 127 VFYFAIPLGSGLGYVVGGLVAQaTGGWRWAFRVTGVLGVLLAILLLLFVREPPRGAAEGGVMAKSTA----------TSF 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 282 SLPIRAMIKSLPLWAILVSYFCEYWLFYTIMAYTPTYISSVLQANLRDSGILSALPFVVGCICIILGGLLADFLLSRKIL 361
Cdd:cd17328 197 LADLKALAKNPSFILSTLGFTAVSFVTGALAFWAPTFFLRAFGVGDLSSADVGLIFGAITCIAGVLGVLLGGILADRLRR 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 362 RLITIRKLFTAIGVLFPSVIL-VSLPWVRSSHSMTMTFLVLSSAISSFceSGALVNFL---DIAPRYTGFLKGLLQVFAH 437
Cdd:cd17328 277 KTPRADPLVCAVGLLAAAPFLfLALVLALSNLLLAWVLLFLGEFLLSL--NWAPVFAIllyVVIPTRRSTASAIQILLSH 354
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 4885441 438 IAG-AISPTAAGFF---------ISQDSEFGWRNVFLLSAAVNISGLVFYL 478
Cdd:cd17328 355 LLGdAGSPYLIGLIsdllrqnkdSPLAEAASLQYALLLCSFVLVLGGFFFL 405
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
297-480 |
9.62e-08 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 53.96 E-value: 9.62e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 297 ILVSYFCEYWLFYTIMAYTPTYISSVLQANLRDSGILSALPFVVGCICIILGGLLADFLLSRKILRLITIrklFTAIGVL 376
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLL---LFALGLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 377 FPSVIlvslpwvrSSHSMTMTFLVLSSAISSFCESGALVNFLDIAPRYT-GFLKGLLQVFAHIAGAISPTAAGFFISQds 455
Cdd:pfam07690 78 LLLFA--------SSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEErGRALGLVSAGFGLGAALGPLLGGLLASL-- 147
|
170 180
....*....|....*....|....*
gi 4885441 456 eFGWRNVFLLSAAVNISGLVFYLIF 480
Cdd:pfam07690 148 -FGWRAAFLILAILSLLAAVLLLLP 171
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
116-388 |
3.29e-07 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 52.18 E-value: 3.29e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 116 SLNYGSFLapIPSGYVAGIFGAK--YVVGAGLF-ISSFLTLFIPlaanaGVALLIVLRIVQGIAQVMVLTGQYSIWVKWA 192
Cdd:cd17321 41 LLAFAALL--LLAGRLGDRFGRKrvFLIGLALFgLASLLCALAP-----SLAFLIAARALQGIGAAAIMPASLALIAATF 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 193 PPLERSQLTTIAGSGSMLGSFIVLLAGGLLCQTIGWPYVFYIFGGIGCAccplwfpliyddpvnhpfisagekryivcsl 272
Cdd:cd17321 114 PGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLV------------------------------- 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 273 aqqdcspgwslpirAMIKSLPLWAILVSYFCEYWLFYTIMAYTPTYISSVLQANLRDSGILSaLPFVVGC-ICIILGGLL 351
Cdd:cd17321 163 --------------ALLLARTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLAL-LPLALAMlVAAPLAGRL 227
|
250 260 270
....*....|....*....|....*....|....*..
gi 4885441 352 ADFLLSRKILRLITirkLFTAIGVLFPSVILVSLPWV 388
Cdd:cd17321 228 ADRFGPRLVLVAGL---LLTAVGLLLLALLGADSSVW 261
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
103-247 |
4.12e-07 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 52.19 E-value: 4.12e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 103 YDWSPEIQGIILSSLNYGSFLAPIPSGYVAGIFGAKYVVGAGLFISSFLTLFIPLAANagVALLIVLRIVQGIAQVMVLT 182
Cdd:cd17325 230 GGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATS--FWLLLLLLALLGLGLGLVFP 307
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4885441 183 GQYSIWVKWAPPLERSQLTTIAGSGSMLGSFIVLLAGGLLCQTIGWPYVFYIFGGIGCACCPLWF 247
Cdd:cd17325 308 ATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFL 372
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
111-469 |
6.08e-07 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 51.47 E-value: 6.08e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 111 GIILSSLNYGSFLAPIPSGYVAGIFGAKYVVGAGLFISSflTLFIPLAANAGVALLIVLRIVQGIAQVMVLTGQYSIWVK 190
Cdd:cd17475 34 GLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMG--AAALLMALVGSYPVLLVLLFLVGAGYGSVQPGGGRAIMR 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 191 WAPPLERSQLTTIAGSGSMLGSFIVLLAGGLLCQTIGWPYVFyIFGGIGCACCPLWFPLIYDDPVnhpfisagekryiVC 270
Cdd:cd17475 112 WFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAF-VVAGLVSILAAVLFWLFYREPP-------------AA 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 271 SLAQQDCSPGWSLpIRAMIKSLPLWAILVSYFCEYWLFYTIMAYTPTYISSVLQANLRDSGILSALPFVVGCICIILGGL 350
Cdd:cd17475 178 SAATESASTLLRS-LKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGR 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 351 LADFLLSRKilrlitiRKLFTAIGVLFPSVILVSLPWVrsSHSMTMTFLVLSSAISSFCESG----ALVNFLDIAP-RYT 425
Cdd:cd17475 257 VSDRVFGGR-------RRPVLVITAAIAAAALLVLSLL--SPGTPLWLLVLLLILLGLFAIGwnglYLTLVAESAGpEQA 327
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 4885441 426 GFLKGLLQVFAHIAGAISPTAAGFFIsqDSEFGWRNVFLLSAAV 469
Cdd:cd17475 328 GTALGLANTINFIGIAIGPPLFGLLV--DATHSYAPAWLALALL 369
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
128-480 |
9.52e-07 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 50.74 E-value: 9.52e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 128 SGYVAGIFGAKYVVGAGLFISSFLTLFipLAANAGVALLIVLRIVQGIAQVMVLTGQYSIWVKWAPPLERSQLTTIAGSG 207
Cdd:cd17312 58 SGFLSDRSNIRRFMSAGLLLSALANIF--MGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTS 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 208 SMLGSFIVLLAGGLLCQTIGWPYVFYIFGGIGCACCPLWFPLIYDDPvnhpfisagekryivcslaqqdcsPGwslpira 287
Cdd:cd17312 136 HNFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAIILFFFLRDSP------------------------PY------- 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 288 mikslpLWAILVSYFCEYWLFYTIMAYTPTYISSVLQANLRDSGILSALPFVVGCICIILGGLLAD--FLLSRKILRLIT 365
Cdd:cd17312 185 ------VWVLSLAYAFVYIVRYACLDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDklFGGRRAPIAVIY 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 366 IRKLFTAIGVLFpsviLVSLPWVRSSHSMTMTFLVLSSAISSFCESGAlvnfLDIAPRY-TGFLKGLLQVFAHIAGAISP 444
Cdd:cd17312 259 MLLMTLSLALFW----FFPHNKLLSIVLLFLIGFFVGGPINLIGGAAA----QDIGRKEaAGTATGFVGLFGYLGASLAG 330
|
330 340 350
....*....|....*....|....*....|....*.
gi 4885441 445 TAAGFFISQdseFGWRNVFLLSAAVNISGLVFYLIF 480
Cdd:cd17312 331 LPLGYIIDH---YGWSTVFYFLISAALLSVLLLLSL 363
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
116-243 |
1.04e-06 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 50.72 E-value: 1.04e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 116 SLNYGSFLapIPSGYVAGIFGAKYVVGAGLFIssfLTLFIPLAANA-GVALLIVLRIVQGIAQVMVLTGQYSIWVK-WAP 193
Cdd:cd17476 43 SLTVGTFI--LIFGRLGDIYGHKKMFVIGSFW---FAIWSLIAGFSpNFIFFIICRALQGLGPAFLLPNAMALLGRtYPP 117
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 4885441 194 PLERSQLTTIAGSGSMLGSFIVLLAGGLLCQTIGWPYVFYIFgGIGCACC 243
Cdd:cd17476 118 GPRKNIVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIFWFL-AILAAIV 166
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
94-479 |
1.21e-06 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 50.70 E-value: 1.21e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 94 KEFKAMAP----AYDWSPEIQGIILS--SLNYGsfLAPIPSGYVAGIFGAKYVVGAGLFISSFLTLFIP--LAANAGVAL 165
Cdd:cd17345 20 NNFSLAQPylieQYGLSKTEIGLIGSalSIAYG--LSKFVMGNLSDRSNPKRFLAIGLILSAIINILIGfvPSATSSVGL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 166 LIVLRIVQGIAQVMVLTGQYSIWVKWAPPLERSQLTTIAGS-----GSMLGSFIVLLAGGLLCQTIGWPYVFYIFGGIGC 240
Cdd:cd17345 98 MFILLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNIshnvgGGLVGPLAGLGLAIFGDGWWRGAFIFPAIIAIIV 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 241 ACCPLWfpLIYDDPV------------NHPFISAGEKRYivcslaqQDCSPgWSLPIRAMIKSLPLWAILVSYFCEYWLF 308
Cdd:cd17345 178 AVIVLF--LGKDTPEseglppieeykgDYPEEADGEEEE-------QELSA-WEIFVKYVLKNKLLWYIAIANVFVYLVR 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 309 YTIMAYTPTYISSVLQANLRDSGILSALPFVVGCICIILGGLLADfllsrkilRLITIRKLFTAIGVLFPSVILVSLPWV 388
Cdd:cd17345 248 YGILDWAPTYLSEVKGFSKAQAMWAFSLFEWAAIPGTLLAGWLSD--------KLFKGRRAPTGIIFMILVIVALIVYWL 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 389 RSSHSMTMTFLVLssaissfceSGAL---------VNFLDIAPRY-TGFLKGLLQVFAHIAGAISPTAAGFFISQdsEFG 458
Cdd:cd17345 320 APNVLVDLIALIA---------LGFLiygpvmligLQALELVPKKaAGTAAGLTGLFGYLGGSVLATALIGIIVD--HFG 388
|
410 420
....*....|....*....|.
gi 4885441 459 WRNVFLLSAAVNISGLVFYLI 479
Cdd:cd17345 389 WNGGFIVLLASCILAIIFLAL 409
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
123-412 |
1.43e-06 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 50.33 E-value: 1.43e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 123 LAPIPSGYVAGIFGAKYVVGAGLFISSFLTLFIPLAAnAGVALLIVLRIVQGIAQVMVLTGQYSIWVKWAPPLERSQLTT 202
Cdd:cd17341 49 LLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALALAV-SSYWGLLVLGFLLGFAGANFASGQPWASFWFPKEKIGGAAGG 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 203 IAGSGSMLGSFIVLL------AGGLLCQTIGWPYVFYIFGGIGCACCPLWFPLIYDDPVNhpfisageKRYIVCSLAQQd 276
Cdd:cd17341 128 IAGAGNMGVAVSQLLapliagAIVFDGGFVGWRNAFFVPGILLAIAAVLVLLFGDDLPTG--------KASALEFLKVQ- 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 277 cspgwslpiRAMIKSLPLWAILVSYFCEYWLFYTIMAYTPTYISSVLQANLRDSGILSALPFVVGCICIILGGLLADFLL 356
Cdd:cd17341 199 ---------LAVLKNYRTWILSLLYGVTFGSFVGFSNVLPTYFKTRFGLPLVTAGILAALFPLAGALARPAGGWLSDRFG 269
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 4885441 357 SRKILRLITIRKLFTAIGVLFPsvilvslpwVRSSHSMTMTFLVLSSAISSFCESG 412
Cdd:cd17341 270 GRRRLWWLFIVMTIGAALLSLS---------LPTSGTNLVLFLALFVALGLGAGAG 316
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
110-382 |
2.84e-06 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 49.22 E-value: 2.84e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 110 QGIILSSLNY-----GSFLAPIpsgyVAGIFGAKYVVGAGLFISSFLTLFipLAANAGVALLIVLRIVQGIAQVMVLTGQ 184
Cdd:cd06180 35 QAGWIATANYagylvGALLASF----LRRRGRARRLIRGGLLLTVLLLAA--MALTSGFAALLALRFLAGAASAFVFVFG 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 185 YSIWVKWAPPLERSQLTTIAGSGSMLGSFIV-LLAGGLLCQTIGWPYVFYIFGGIGCACCPLWFPLIYDDPVNHPFISAG 263
Cdd:cd06180 109 SNLVLHHATAAGRGHLIGLLFAGVGLGIALSgLLVPAGLGGGLSWRAGWLALALLSAVLLLLSFLLLRRGPSAPTEASAA 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 264 EKRyivcslaqqdcsPGWslpiramikSLPLWAILVSYFCEYWLFYTIMAYTPTYissvlqanLRDSGILSALPFVVGCI 343
Cdd:cd06180 189 ESA------------PGL---------NRPLWRLALAYGLFGFGYIITATFLPLI--------ARETGAGSLLAGLLWSL 239
|
250 260 270
....*....|....*....|....*....|....*....
gi 4885441 344 cIILGGLLADFLLSRKILRLITIRKLFTAIGVLFPSVIL 382
Cdd:cd06180 240 -FGLAAVPSCFLWGALSDRWGTRRALAANLLVQAVGVLL 277
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
106-475 |
2.84e-06 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 49.52 E-value: 2.84e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 106 SPEIQGIILSSLNYGSFLAPIPSGYVAGIFGAKYVVGAGLFISSFLTLFIPLAANAgvALLIVLRIVQGIAQVMVLTGQY 185
Cdd:cd17316 34 SLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTP--ILLLVLRFLQGIGIGGEYPGAS 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 186 SIWVKWAPPLERSQLTTIAGSGSMLGSFIVLLAGGLL----CQTIGWPYVFYIFGGIGcaccplwfpLIyddpvnhpfis 261
Cdd:cd17316 112 TYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLipllSGDWGWRILFLIGALPA---------LL----------- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 262 agekryivcslaqqdcspgwSLPIRamiksLPLWAILVSYFCEYWLFYTIMAYTPTYISSVLQANLRDSGILSALPFVVG 341
Cdd:cd17316 172 --------------------ALLLR-----RRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGA 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 342 CICIILGGLLADFLLsrkilrlitiRKLFTAIGVLfpsVILVSLPWVRSSHSMTMTFLVLSSAISSFCESGALVNFLDIA 421
Cdd:cd17316 227 LVGALIAGLLSDRIG----------RKKTLVIGLI---LSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYL 293
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4885441 422 P-------RYTGFlkGLLQVFAHIAGAISPTAAGFFISqdSEFGWRNVFLLSAAVNISGLV 475
Cdd:cd17316 294 AelfptevRATGV--GLSYNLGRLGGGGAPPLIALLLA--STGGTGVPALILALLAIVALI 350
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
111-455 |
4.49e-06 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 48.86 E-value: 4.49e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 111 GIILSSLNYGSFLAPIPSGYVAGIFGAKYVVGAGLFISSFLTLFIPLAANAGVALLIVLRIVQGIAQVMVLTGQY--SIW 188
Cdd:cd17333 34 SVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGAGILDTGANTFvgALF 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 189 VKwAPPLERSQLTTIAGSGSMLGsfiVLLAGGLLCQTIGWPYVFYIFGGIGCACCPLWFPLIYDDPVnhpfisagekryi 268
Cdd:cd17333 114 EE-SSATRLNVLHGFFGLGALIG---PLIATSLLTSELSWSWAYLIIGLIYLLLAILILLTLFPELP------------- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 269 vcSLAQQDCSPGWSLPIRAMIKSLPLWAILVSY-FCEYWLFYTIMAYTPTYISSVLQANLRDSGILSALPFVVGCICIIL 347
Cdd:cd17333 177 --SARNPQQSVGAFSASASRLLRNPSIILGALAlFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLL 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 348 GGLLADFLLSRKilrlitirklFTAIGVLFPSVILVSLPWVRSSHSMTMTFLVLSSAISSFCESgALVNFLDIAPRYTGF 427
Cdd:cd17333 255 GGPISRRIKPHT----------LLVLSGSGALLGLLILLLAPTLVVGLVATALLGLFMAALFPT-ILSLGISNLPYAKGK 323
|
330 340
....*....|....*....|....*...
gi 4885441 428 LKGLLQVFAHIAGAISPTAAGFFISQDS 455
Cdd:cd17333 324 GTSVLLAAGSIGGAIIPFIMGFIAEAVG 351
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
126-245 |
1.31e-05 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 47.19 E-value: 1.31e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 126 IP-SGYVAGIFGAKYVVGAGLFISSFLTLFIPLAANAGValLIVLRIVQGIAQ-VMVLTGQySIWVKWAPPLERSQLTTI 203
Cdd:cd17503 48 IPlSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLAS--LIIFRILQGFGGgVLIPLAQ-TILLRIYPPEKRGAAMGL 124
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 4885441 204 AGSGSMLGSFIVLLAGGLLCQTIGWPYVFYI---FGGIGCACCPL 245
Cdd:cd17503 125 VGLVILLAPAIGPTLGGWLTDNLSWRWIFYInlpIGILALLLAPL 169
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
111-242 |
2.17e-05 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 44.18 E-value: 2.17e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 111 GIILSSLNYGSFLAPIPSGYVAGIFGAKYVVGAGLFISSFLTLFIPLAANAGValLIVLRIVQGIAQVMVLTGQYSIWVK 190
Cdd:TIGR00880 1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITV--LIIARFLQGFGAAFALVAGAALIAD 78
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 4885441 191 WAPPLERSQLTTIAGSGSMLGSFIVLLAGGLLCQTIGWPYVFYIFGGIGCAC 242
Cdd:TIGR00880 79 IYPPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAA 130
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
111-447 |
2.32e-05 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 46.75 E-value: 2.32e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 111 GIILSSLNYG-SFLA-PIPS---GYVAGIFGAKYVVGAGLF---ISSFLTLFIPLAANAGVA---LLIVLRIVQGIAqvm 179
Cdd:cd17369 42 GTLAAFATFGvGFLArPLGGvvfGHFGDRIGRKKTLVLTLLlmgIATFLIGLLPTYAQIGILapiLLVLLRLLQGLA--- 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 180 vLTGQYS----IWVKWAPPLERSQLTTI----AGSGSMLGSFIVLLAGGLLCQ----TIGW--PYVFYIF-GGIGcaccp 244
Cdd:cd17369 119 -LGGEWGgavlMAVEHAPPKRRGFYGSFpqlgAPVGLLLATGVFLLLSALLSDeaflSWGWriPFLLSAVlVAVG----- 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 245 LWFPL-IYDDPVnhpFISAGEKRYIVcslaqqdcspgwSLPIRAMIKSLP--LWAILVSYFCEYWLFYTIMAYTPTYISS 321
Cdd:cd17369 193 LYIRLrLEETPV---FRRAKEAGQVV------------RAPLVEVLRRHWraLLLAIGLRLAENVLFYLFTTFALSYATQ 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 322 VLQANLRDSGILSALPFVVGCICIILGGLLADFLLSRKILRLITIrklftAIGVL-FPSVILVSLpwvRSSHSMTMTFLV 400
Cdd:cd17369 258 TLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGAL-----LAALFaFPFFWLLDT---GSTWLIVLAAVV 329
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 4885441 401 LSSAISS--FCESGA-LVNFLDIAPRYTGFLKGlLQVFAHIAGAISPTAA 447
Cdd:cd17369 330 VLGVLHGmmYGPQAAfLAELFPTRVRYTGASLG-YQLGAILGGGFAPLIA 378
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
122-481 |
4.20e-05 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 45.64 E-value: 4.20e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 122 FLAPIpSGYVAGIFGAKYVVGAGLFISSFLTLfIPLAANAgVALLIVLRIVQGIAQVMVLTGQYSIWVKWAPPLERSQLT 201
Cdd:cd17473 50 LFAPL-AGWLADRFGRKRLLIAGLLLYGIGGV-AGLFLDS-LYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKML 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 202 TIAGSGSMLGSFIVLLAGGLLCQtIGWPYVFYIFgGIGCACCPLWFPLIYDDPVNHPFISAGEKryivcslaqqdcspgw 281
Cdd:cd17473 127 GLQSAAMSLGGVVFLLLGGALAE-IGWRAPFLVY-LLALPVLILVLLFLPEPARKSKSAASPGA---------------- 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 282 slPIRAMIKSLPLWAILVSYFCEYWLFYTIMAYTPTYISSVLQANLRDSGILSALPFVVGCICIILGGLLADFLLSRKIL 361
Cdd:cd17473 189 --ATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLL 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 362 RLITIrklFTAIGVLfpsvilvsLPWVRSSHSMTMTFLVLSSAISSFCESGALVNFLDIAP-RYTGFLKGLLQVFAHIAG 440
Cdd:cd17473 267 AIGFA---LMALGFL--------LLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPpELRGRAMGIVTSAFFLGQ 335
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 4885441 441 AISPTAAGFFISQdsEFGWRNVFLLSAAVNISGLVFYLIFG 481
Cdd:cd17473 336 FLSPLVLGPLVNL--TGGLSGAFLILGVLALVLAIVLLLLR 374
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
98-424 |
4.59e-05 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 45.81 E-value: 4.59e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 98 AMAPAYDWSPEIQGIILSSLNYGSFLAPIPSGYVAGIFGAKYVVGAGLFISSFLTLFIPLAANagVALLIVLRIVQGI-- 175
Cdd:TIGR00895 42 AISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATN--VTQLLILRFLAGLgl 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 176 ----AQVMVLTGQYsiwvkwAPPLERSQLTTIAGSGSMLGSFIVLLAGGLLCQTIGWPYVFYIFGGIGCACCPL---WFP 248
Cdd:TIGR00895 120 gglmPNLNALVSEY------APKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLlmrFLP 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 249 -----LIYDDPVNHPFIS---AGEKRYIVCS-LAQQDCSPGWSLPIRAMIKS-------LPLWailVSYFCEYWLFYTIM 312
Cdd:TIGR00895 194 esidfLVSKRPETVRRIVnaiAPQMQAEAQSaLPEQKSTQGTKRSVFKALFQgktaritVLLW---LLYFMLLVGVYFLT 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 313 AYTPtYISSVLQANLRDSGILSALPFVVGCICIILGGLLADFLLSRkilrlitirklFTAIGVLFPSVILVSLPWVRSSH 392
Cdd:TIGR00895 271 NWLP-KLMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRLGPR-----------VTALLLLLGAVFAVLVGSTLFSP 338
|
330 340 350
....*....|....*....|....*....|..
gi 4885441 393 SMTMTFLvlssAISSFCESGALVNFLDIAPRY 424
Cdd:TIGR00895 339 TLLLLLG----AIAGFFVNGGQSGLYALMALF 366
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
105-480 |
6.49e-05 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 45.30 E-value: 6.49e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 105 WSPEIQGIILSSLNYGSFLAPIPSGYVAGIFGAKYVVGAGLFISSFLTLFIPLAANagVALLIVLRIVQGIAQVMVLTGQ 184
Cdd:cd17329 32 LSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHS--PWLFAIALVLTGFGGGLFEPAS 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 185 YSIWVKWAPPLERSQLTTI--------AGSGSMLGSFIVLLAGGLLCqtigwpyvfyIFGGIGCACCPLWFPLIYDDPVN 256
Cdd:cd17329 110 EAMIADVTTPENRTRAFSLlywainlgVAIGPLLGGLLLLYSFRLLF----------LAAAVLFLLAALVLLFLLPETRP 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 257 HPFISAGEKRYIVCSLAQQDCspgwslpiramikslPLWAILVSYFCEYWLFYTIMAYTPTYISSVLQANLRDSGILSAL 336
Cdd:cd17329 180 KRRAAEKTEILRGYKIVLRDR---------------AFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLAL 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 337 PFVVGcicIILGGLLADFLLSRKILRLITIRKLFTAIGVLFPSVILVSLPWVRSSHSMTMTFLVLSSAISsfcesgALVN 416
Cdd:cd17329 245 NALLI---VLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQ------TLVA 315
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4885441 417 flDIAP-RYTGFLKGLLQVFAHIAGAISPTAAGFFISQDSEFGwrnVFLLSAAVNISGLVFYLIF 480
Cdd:cd17329 316 --ALAPpDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGL---PWLILAALGLIAAALLLGL 375
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
120-440 |
7.76e-05 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 44.99 E-value: 7.76e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 120 GSFLAPIPSGYVAGIFGAKYVVGAGLFISSFLTLFIPLAaNAGVALLIVLRIVQGIAQVMVLTGQYSIWVKWAPPLERSQ 199
Cdd:TIGR00886 49 AGAVLRIILGFLVDIFGPRYTTALSLLLLAIPCLWAGLA-VQSYSVLLLIRLFIGIAGGSFASCMPWISFFFPKKIQGTA 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 200 LTTIAGSGSMlgsfivllaGGLLCQTIGWPYVFYIFGGIGCACCPLWFPLIYDDPVNHPFISAgekryIVCSLAQQDCSP 279
Cdd:TIGR00886 128 LGLAAGWGNM---------GGGVAQFVMPPIIGSLIFGGGQPAHLAWGWAFVIVPAGILLLPA-----LLIFFVGADTPP 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 280 GWSLPIRAMIKS-------LPLWAILVSYFCEYWLFYTIMAYTPTYISSVLQANLRDSGILSALPFVVGCICIILGGLLA 352
Cdd:TIGR00886 194 GKPATGKLSFKEalkvfgnRHTWILALLYSVTFGSFLGVSSIFAMLFKDQFGLSKVQAGAYASLGGFLGSLARPAGGAIS 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 353 DFLLSRKILRLITIRKLFTAIGVLFPSVILVSLpwvrsshsmtMTFLVLSSAISSFCESGALVNFLDIA---PRYTGFLK 429
Cdd:TIGR00886 274 DRLGGARKLLMNFLGVAMGAFLVVLGLVSDGSL----------AAFIVLFVALFFFAGAGNGSTFALVPhifRRATGAVS 343
|
330
....*....|.
gi 4885441 430 GLLQVFAHIAG 440
Cdd:TIGR00886 344 GLIGAIGNLGG 354
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
104-250 |
1.03e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 44.53 E-value: 1.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 104 DWSPEIQGIILSSLNYGSFLAPIPSGYVAGIFGAKYVVGAGLFISSFLTLFIPLAANagVALLIVLRIVQGIAQVMVLTG 183
Cdd:cd06173 240 GGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPS--LWLLLAALFLLGLAGGLFNVP 317
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4885441 184 QYSIWVKWAPPLERSQLTTIAGSGSMLGSFIVLLAGGLLCQTIGWPYVFYIfGGIGCACCPLWFPLI 250
Cdd:cd06173 318 LNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLL-AGALLLLAALLLLLL 383
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
99-478 |
2.59e-04 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 43.31 E-value: 2.59e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 99 MAPAYDWSPEIQGIILSSLNYGSFLAPIPSGYVAGIFGAKYVVGAGLFISSFLTLFIPLAANAGVALLIVLRIVQGIA-- 176
Cdd:cd17478 22 LIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSAaf 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 177 --QVMVLTGQYSiwvkwapPLERSQLTTIAGSGSMLGSFIVLLAGGLLCQTIGWPYVFYIFGGIGCACCPLWFPLiyddp 254
Cdd:cd17478 102 hpEGARLASQAA-------GGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRL----- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 255 vnhpfisageKRYIVCSLAQQDCSPGWSLPIRAMIKslPLWAILVSYFCEYWLFYTIMAYTPTYISSVLQANLRDSGILS 334
Cdd:cd17478 170 ----------RPLKKPEAKKAAAKSSARSTLKGVWR--ALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYSLVFAGLLLS 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 335 ALpFVVGCICIILGGLLADFLLSRKILRLITIRKLFTAIGVLFpsvilVSLPWvrsshsmTMTFLVLSSAISSFCESGAL 414
Cdd:cd17478 238 LF-LFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLL-----TPGIW-------SYILLVLAGFLLFASFPVTV 304
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 4885441 415 VNFLDIAPRYTGFLKGLLQVFAHIAGAISPTAAGFFISQdseFGWRNVFLLSAAVNISGLVFYL 478
Cdd:cd17478 305 VLAQELLPGNVGLASGLMMGLSFGLGGIGAPVLGALADA---FGLESVLLILALLPLLGALLAF 365
|
|
| PRK15075 |
PRK15075 |
tricarballylate/proton symporter TcuC; |
308-427 |
9.48e-04 |
|
tricarballylate/proton symporter TcuC;
Pssm-ID: 237902 [Multi-domain] Cd Length: 434 Bit Score: 41.47 E-value: 9.48e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 308 FYTIMAYTPTYISSVLQANLRDSGILSALPFVVGCICIILGGLLADFLLSRKILRLITIRKLFTAIGVLFpsvILVSLPw 387
Cdd:PRK15075 254 FYLITVYTPTFGKTVLHLSAADSLLVTLCVGVSNFIWLPIGGALSDRIGRRPVLIAFTVLAILTAYPALS---WLVAAP- 329
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 4885441 388 vrSSHSMTMTFLVLSSAISSFceSGALVNFL-DIAP---RYTGF 427
Cdd:PRK15075 330 --SFARMLAVELWLSFLYGSY--NGAMVVALtEVMPaevRTAGF 369
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
98-476 |
1.09e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 41.41 E-value: 1.09e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 98 AMAPAYDWSPEIQGIILSS-LNYGSFLAPIpSGYVAGIFGAKYVVGAGLFISSFLTLFIPLAANagVALLIVLRIVQGIA 176
Cdd:cd17504 21 TIQREFGTSAAAVSWVLTAyLLVGAVSTPI-LGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPN--LPVLIAGRALQGIG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 177 QVMVLTGQYSIWVKWAPPLERSQLTTIAGSGSmLGSFIVLLAGGLLCQTIGWPYVFY---IFGGIGCACCPLwfpliydd 253
Cdd:cd17504 98 GAVFPLAFALVREEFPPERVPVAQGILSATFG-IGAGIGLPLGGWIVQHLGWRWIFWtaaPVAVLLAALVPL-------- 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 254 pvnhpfisagekryivcslaqqdcspgwsLPIRAMIKSLPLWAILVSY---FCEYWLFYTIMAYTPT-----YISSVLQA 325
Cdd:cd17504 169 -----------------------------IDLRLLRRRNVLLANITALlagFGMFMVFQLLPQLLQLptptgFGLGITEA 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 326 NLrdsgilSALPFVVGcicIILGGLLADFLLSRkilrlITIRKLFtAIGVLFPSVILVSLPWVRSSHSMTMTFLVLSSAI 405
Cdd:cd17504 220 GL------LLLPGALV---MLIAGPLAGRLIAR-----VGPRRVL-LIGLVISAVGLLLLALLHSSLWALVVALLLIGIG 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 406 SSFCeSGALVNFLDIA--PRYTGFLKGLLQVFAHIAGAISPTAAGFFISQ----------DSEFGWRNVFLLSAAVNISG 473
Cdd:cd17504 285 LGLA-FASLPNIVVESvpPDRTGIATGMNTVLRTIGSAIGPAIAGAILTTytvsitsggvPTEGAYVLAFLIGAALALAA 363
|
...
gi 4885441 474 LVF 476
Cdd:cd17504 364 LLL 366
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
120-427 |
1.23e-03 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 41.21 E-value: 1.23e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 120 GSFLAPIPS---GYVAGIFGAKYVVGAGLFISSFLTLFIPLA---ANAGVA---LLIVLRIVQGIAQVMVLTGQYSIWVK 190
Cdd:cd17368 49 GFFMRPIGAivlGAYADRIGRKPAMTLTLAIMALGTLLIALAptyATIGIAaplLVLLARLLQGFAAGGEVGGVTAYLVE 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 191 WAPPLERSQLTTIAGSGSMLGSFIVLLAGGLLCQTI--------GWPYVFYIfggiGCACCP--LWFPLIYDDPVNHP-F 259
Cdd:cd17368 129 AAPPGRRGFYTSWQSASQQVAIVAGALVGYLLSLTLtaealaewGWRIPFFI----GLLIIPlgLWLRRSLEETEAFLeR 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 260 ISAGEKRYIVCSLAQqdcspgwslPIRAMIKSLPLWAILVSyfceywLFYTIMAYTPTYISSVLQANLRDSGILSALPFV 339
Cdd:cd17368 205 KARPTRRELFALLAN---------NRRIILLGMLLVAGSTV------TFYFTTVYTPTYAKTVLGLSARDSFLVTLLAGV 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 340 VGCICIILGGLLADFLLSRKILRLITIRKLFTaigvLFPsvilvSLPWVRSSHSMTMTFLVLS--SAISSFCESGALVNF 417
Cdd:cd17368 270 ANFIWAPLGGALSDRIGRRPVLLVITLAALVT----LYP-----VFAWLTAAPSFGRLLLVLLvlSFFFGMYGGAMVVAL 340
|
330
....*....|...
gi 4885441 418 LDIAPRY---TGF 427
Cdd:cd17368 341 VELFPVRvrsTGF 353
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
294-480 |
1.42e-03 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 41.01 E-value: 1.42e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 294 LWAILVSYFCEYWLFYTIMAYTPtYISSVLQANLRDSGILSALPFVVGCICIILGGLLADFLLSRKILrlitirklftAI 373
Cdd:COG2271 12 LALLFLAYFLNYLDRSNLSVAAP-PLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVL----------AI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 374 GVLFPSVILVSLPWVRSSHSMTMTFLVLSSAISSFCESGALVNFLDIAPRYTGFLKGLLQVFAHIAGAISPTAAGFFISQ 453
Cdd:COG2271 81 GLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAA 160
|
170 180
....*....|....*....|....*..
gi 4885441 454 dseFGWRNVFLLSAAVNISGLVFYLIF 480
Cdd:COG2271 161 ---FGWRAAFLILGLPGLLLALLRFWL 184
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
129-251 |
2.56e-03 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 39.85 E-value: 2.56e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 129 GYVAGIFGAKYVVGAGLFISSFLTLFIPLAANAGValLIVLRIVQGIAQVMVLTGQYSIWVKWAPPLERSQLTTIAGSGS 208
Cdd:cd17502 51 GKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTM--LIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVF 128
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 4885441 209 MLGSFIVLLAGGLLCQTIGWPYVFYI---FGGIGCACCPL-WFPLIY 251
Cdd:cd17502 129 GIASVAGPLIGGAFTDHLSWRWCFYInlpIGGLALALLRTiLLSSIF 175
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
122-480 |
2.76e-03 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 39.91 E-value: 2.76e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 122 FLAPIPSGYVAGIFGAKYVVGAGLFISSFLTLFIPLAANAG---VALLIVLRIVQGIAQVMVLTGQYSIWVKWAPPLERS 198
Cdd:cd06173 48 LLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGslsLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLV 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 199 QLTTIAGSGSMLGSFIVLLAGGLLCQTIGWPYVF------YIFGGIGCACCPLWFPLIYDDPVNHPFISAGEKRYIVcsl 272
Cdd:cd06173 128 RANALNSLATQLARIIGPALGGLLVALLGPGGAFainalsFLLSALLLLFIRRPPPAAPGESSSLLLRDLREGLRYL--- 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 273 aqqdcspGWSLPIRAMIKSLPLWAILVSYFceywlfytiMAYTPTYISSVLQANLRDSGILSALPFVvgciciilGGLLA 352
Cdd:cd06173 205 -------RRSPLLRLLLLALALFALLGGAL---------TVLLPLLAKEVLGGGAAGYGLLLAAFGV--------GALLG 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 353 DFLLSRKILRLITIRKLFTAIGVLFPSVILVSLpwvrsSHSMTMTFLVLssAISSFCESGALVNF-----LDIAPRYTGF 427
Cdd:cd06173 261 ALLLGRLSKRRRRGRLLLIGALLLGLALLVLGL-----SPSLWLLLAAL--FLLGLAGGLFNVPLntllqLRVPDELRGR 333
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 4885441 428 LKGLLQVFAHIAGAISPTAAGFFISQdseFGWRNVFLLSAAVNISGLVFYLIF 480
Cdd:cd06173 334 VFSVYNALNSGAMPLGALLAGLLADA---LGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
104-245 |
3.15e-03 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 39.88 E-value: 3.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 104 DW--SPEIQGIILSSLNYGSFLAPIPSGYVAGIFGAKYVVGAGLFISSFLTLFIPLAANagVALLIVLRIVQGIAQVMVL 181
Cdd:cd17365 28 DWglSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQS--VLQLALLRFLTGLGLGAAM 105
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 4885441 182 TGQYSIWVKWAPPLERSQLTTIAGSGSMLGSFIVLLAGGLLCQTIGWPYVFYIFGGIGCACCPL 245
Cdd:cd17365 106 PNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILLPL 169
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
106-383 |
3.28e-03 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 39.90 E-value: 3.28e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 106 SPEIQGIILSSLNYGSFLAPIPSGYVAGIFGA-KYVVGAGLFISSFLTLFIPLAANagVALLIVLRIVQGIAQVM--VLT 182
Cdd:cd17490 29 SLSMIGIILGAYGISQMLLRIPLGILSDRIGKrKLFIIIGLLFTVLASLIMILFPS--PWGLLIARFLSGIAAATwvSFT 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 183 GQYSiwvKWAPPLERSQLTTIAGSGSMLGSFIVLLAGGLLCQTIGWPYVFYIFGGIGCACCPLWFPLIYDDPVNHPFISA 262
Cdd:cd17490 107 VLYA---SYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGFILSLFIKEERREKKPVLTE 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 263 GEKryivcslaqqdcspgwslpIRAMIKSLPLWAI-LVSYFCEYWLFYTIMAYTPTYISSvLQANLRDSGILSALPFVVG 341
Cdd:cd17490 184 LKE-------------------LLSVLKDKKLLFFsLLAILQQMITFSTTFGFTPLIAKQ-LGASSFQLGLLSIIYLLPN 243
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 4885441 342 ciciILGGLLADFLLSRKilrLITIRKLFTAIGVLFPSVILV 383
Cdd:cd17490 244 ----ALASLLSGTLFYKK---LGERNTIIIGFLLLGAYCFLI 278
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
111-483 |
6.00e-03 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 38.85 E-value: 6.00e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 111 GIILSSLNYGSFLAPIPSGYVAGIFGAKYVVGAGLFISSFLTLFipLAANAGVALLIVLRIVQGIAQVMVLTGQYSIWVK 190
Cdd:cd17343 41 GLITSSQSLAYAISKFIGGVLSDQISARWLFSSGLVLSGLTTVA--FSGSSSVWVFSILWFLNGLAQGLGWPPCAKILRK 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 191 WAPPLERSQLTTIAGSGSMLGSFIVLLAGGLLCQTIGWPYVFYIFGGIGCACCPLWFPLIYDDP--VNHPFISAGEKRyi 268
Cdd:cd17343 119 WFSPSQFGTWWSVLSTSMNLAGSLGPILATLLALSYGWRSTLSISGTVAVVMSVVCLLFIKNEPsdVGLNNIEEEESK-- 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 269 vcslAQQDCSPGWSLPIRAMIKSLPLWAILVSYFCEYWLFYTIMAYTPTY-ISSVLQANLRDSGILSALPfVVGCICIIL 347
Cdd:cd17343 197 ----GKKKKSPRGESTLKELLLSPFLWLLSLGYLVVFGVKTAVTDWGQLFlIQDKGQSALTGSSFMSSLE-VGGFVGSIA 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 348 GGLLADFLLSRKILRLITIRKLFTAIGVLFP-SVILVSLPWVRSSHSMTMTFLVLSSAIsSFCESGALVNFLDIA----- 421
Cdd:cd17343 272 AGYLSDWAVAKHGSSSRGNPRMPLALVFMAGlTVSLHLFRVHITSDSSELFILLLGFLI-GFSLYGPIAIFGVIAnesap 350
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4885441 422 PRYTGFLKGLLQVFAHIAGAIsptaAGFFISQ-DSEFGWRNVFLLSAAVNISGLVFYLIFGRA 483
Cdd:cd17343 351 SHLCGTSHAIVALAANVGGVL----AGLPFSYiAKHYDWRTAFLLLEILCAITVVILFLLRNI 409
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
106-234 |
6.06e-03 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 38.71 E-value: 6.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 106 SPEIQGIILSSLNYGSFLAPIPSGYVAGIFGAKY---VVGAGLFISSFLTLFIPlaanaGVALLIVLRIVQGIAqVMVLT 182
Cdd:cd17315 32 STSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKsllIAAVLYVIGALLSALAP-----NVWVLIVGRFLLGLG-VGLAS 105
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 4885441 183 GQYSIWV-KWAPPLERSQLTTIAGSGSMLGSFIVLLAGGLL--CQTIGWPYVFYI 234
Cdd:cd17315 106 VLVPLYIsEIAPAKIRGALGTLNQLMITFGILLAYLLGLALslSPPGWWRLMFAL 160
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
294-482 |
6.11e-03 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 39.09 E-value: 6.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 294 LWAILVSYFCEYWLFYTIMAYTPTyISSVLQANLRDSGILSALPFVVGCICIILGGLLADfllsrkilrLITIRKLFTAi 373
Cdd:COG2223 7 LLLATLAFFLAFGVWYLWSVLAPP-LAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVD---------RFGPRRVLLI- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 374 gvlfpSVILVSLPWVRSSHSMTMTFLVLSSAISSFCESGALVNFLDIA-----PRYTGFLKGLLQVFAHIAGAISPTAAG 448
Cdd:COG2223 76 -----GLLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVskwfpPDRRGLALGLAAGGGNLGAAVAAFLAP 150
|
170 180 190
....*....|....*....|....*....|....
gi 4885441 449 FFISQdseFGWRNVFLLSAAVNISGLVFYLIFGR 482
Cdd:COG2223 151 LLIAA---FGWRNAFLILGILLLVVAVLAWLFLR 181
|
|
| MFS_SLC37A1_2 |
cd17344 |
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; ... |
130-475 |
7.08e-03 |
|
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 members 1 (SLC37A1) and 2 (SLC37A2) are also called sugar phosphate exchangers 1 (SPX1) and 2 (SPX2). SLC37A1 and SLC37A2 are ER-associated, Pi-linked antiporters that can transport glucose-6-phosphate (G6P) but are insensitive to chlorogenic acid, a competitive inhibitor of physiological ER G6P transport, unlike SLC37A4, the best characterized SLC37 family member and is the physiological G6P transporter (G6PT). SLC37A1 and SLC37A2 belong to the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340902 [Multi-domain] Cd Length: 400 Bit Score: 38.84 E-value: 7.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 130 YVAGIFGA----KYVVGAGLFISSFLTLFIPLAANAGVALL---IVLRIVQGIAQVMVLTGQYSIWVKWAPPLERSQLTT 202
Cdd:cd17344 80 FFSGHIGErlplRYFLSFGMLLSGLFTALFGLGYYWNIHSLwyfVVVQILAGLFQSTGWPSVVACVGNWFGKGKRGLIMG 159
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 203 IAGS----GSMLGSfivLLAGGLLCQTIGWPYVF--YIFGGIGCACcplWFPLIYDDPVNHPFisagekryivcslaqqd 276
Cdd:cd17344 160 IWNShtsvGNILGS---LIAGIFVSSAWGLSFIVpgIIIAAMGVLV---FLFLVEHPPGVIEF----------------- 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 277 cspgwslpiramikSLPL-WAILVSYFCEYWLfytimaytPTYISSVLQANLRDSGILSALPFVVGCICIILGGLLADFL 355
Cdd:cd17344 217 --------------SLCLfFAKLVSYTFLYWL--------PLYISNTAILSAKKAGDLSTLFDVGGIVGGILAGYISDYT 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 356 LSRKIlrlitirklfTAIGVLFPSVILVSLPWVRSSHSMTMTFLVLSSaissfceSGALVNF------------LDIAPR 423
Cdd:cd17344 275 GGRAT----------TCAAMLILAAPMLFIYNYFGQVSMTTNIVLLIV-------CGLLVNGpyalittavsadLGTHKS 337
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 4885441 424 YTGFLKGLLQVFAHIAG------AISPTAAGFFisqdSEFGWRNVF-LLSAAVNISGLV 475
Cdd:cd17344 338 LKGNARALATVTAIIDGtgsigaALGPLLAGLI----SSRGWNNVFyMLIAADVCAGLL 392
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
284-480 |
7.24e-03 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 38.42 E-value: 7.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 284 PIRAMIKSLPLWAILVSYFCEYWLFYTIMAYTPtYISSVLQANLRDSGILSALPFVVGCICIILGGLLADFLLSRKILRL 363
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPALP-LIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885441 364 ITIrkLFTAIGVLFPsvilvslpwvrssHSMTMTFLVLSSAISSFCESGALVNFLDIAPRYT-----GFLKGLLQVFAHI 438
Cdd:COG2814 81 GLL--LFALGSLLCA-------------LAPSLWLLLAARFLQGLGAGALFPAALALIADLVpperrGRALGLLGAGLGL 145
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 4885441 439 AGAISPTAAGFFISQdseFGWRNVFLLSAAVNISGLVFYLIF 480
Cdd:COG2814 146 GPALGPLLGGLLADL---FGWRWVFLVNAVLALLALLLLLRL 184
|
|
| |
