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Conserved domains on  [gi|18491024|ref|NP_005691|]
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dipeptidyl peptidase 3 isoform 1 [Homo sapiens]

Protein Classification

dipeptidyl peptidase 3( domain architecture ID 10507915)

dipeptidyl peptidase 3 is an M49 family metallopeptidase that catalyzes the release of an N-terminal dipeptide from a peptide comprising four or more residues, with broad specificity

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Peptidase_M49 pfam03571
Peptidase family M49;
143-704 0e+00

Peptidase family M49;


:

Pssm-ID: 460976  Cd Length: 550  Bit Score: 933.44  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18491024   143 LWQTCGELMFSLEPRLRHLGLGKEG-ITTYFSGN-CTMEDAKLAQDFLDSQNLSAYNTRLFKEVDGEgkpyYEVRLASVL 220
Cdd:pfam03571   1 LWEKVKDAIYSLDPRLLLLGFPSEGhVSTYYSGNdITKEEIEAVQKFLEKKGILPENTRLFKTSDGD----FEILVASNE 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18491024   221 GSEpsldsEVTSKLKSYEFRGSPFQVTRGDYAPILQKVVEQLEKAKAYAANSHQGQMLAQYIESFTQGSIEAHKRGSRFW 300
Cdd:pfam03571  77 ESE-----EYPEELETGEFNGKKVTLTYGDHSPELKKIVENLEKAKKYAANDTQKKMLEKYIESFETGSIEAHKDSQRHW 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18491024   301 IQDKGPIVESYIGFIESYRDPFGSRGEFEGFVAVVNKAMSAKFERLVASAEQLLKELPWPPTFEKDKFLTPDFTSLDVLT 380
Cdd:pfam03571 152 VKDKGPVVETNIGFIETYRDPAGVRGEFEGFVAIVNKERSAKFGKLVDNAEKFIPLLPWPKDFEKDKFLKPDFTSLEVLT 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18491024   381 FAGSGIPAGINIPNYDDLRQTEGFKNVSLGNVLAVAYatQREKLTFLEEDDKDLYILWKGPSFDVQVGLHELLGHGSGKL 460
Cdd:pfam03571 232 FAGSGIPAGINIPNYDDIRQNEGFKNVSLGNVLSAKA--PNEKITFISEEDQELYKKYRDPAFEVQVGLHELLGHGSGKL 309

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18491024   461 FVQDEKGAFNFDQETVINPETGEQIQSWYRSGETWDSKFSTIASSYEECRAESVGLYLCLHPQVLEIFGFEGA-DAEDVI 539
Cdd:pfam03571 310 LQETADGKFNFDKENPPNPLTGKPITSWYKPGETWGSVFGSLASSYEECRAECVALYLSLNKEVLEIFGFTDKeEADDVI 389

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18491024   540 YVNWLNMVRAGLLALEFYTPEAFNWRQAHMQARFVILRVLLEAGE-GLVTITPTTGSDgrPDARVRLDRSKIRSVGKPAL 618
Cdd:pfam03571 390 YVNWLQMARAGLLALEFYDPETKKWGQAHMQARFAILKVLLEAGDaGFVKLEETKDED--SDLTIRLDRSKILTVGKPAI 467

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18491024   619 ERFLRRLQVLKSTGDVAGGRALYEGYATVTdappECFLTLRDTVLLRKESRKLIVQPNTRLEGSD-VQLLEYEASAAGLI 697
Cdd:pfam03571 468 GDFLLKLQVYKSTADVEAGTEFYEDYTTVD----EEFLKWRDIVLAKKQPRKVFVQANTVLNDGGkVELKEYEETPEGMI 543


                  ....*..
gi 18491024   698 RSFSERF 704
Cdd:pfam03571 544 QSFVERF 550
 
Name Accession Description Interval E-value
Peptidase_M49 pfam03571
Peptidase family M49;
143-704 0e+00

Peptidase family M49;


Pssm-ID: 460976  Cd Length: 550  Bit Score: 933.44  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18491024   143 LWQTCGELMFSLEPRLRHLGLGKEG-ITTYFSGN-CTMEDAKLAQDFLDSQNLSAYNTRLFKEVDGEgkpyYEVRLASVL 220
Cdd:pfam03571   1 LWEKVKDAIYSLDPRLLLLGFPSEGhVSTYYSGNdITKEEIEAVQKFLEKKGILPENTRLFKTSDGD----FEILVASNE 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18491024   221 GSEpsldsEVTSKLKSYEFRGSPFQVTRGDYAPILQKVVEQLEKAKAYAANSHQGQMLAQYIESFTQGSIEAHKRGSRFW 300
Cdd:pfam03571  77 ESE-----EYPEELETGEFNGKKVTLTYGDHSPELKKIVENLEKAKKYAANDTQKKMLEKYIESFETGSIEAHKDSQRHW 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18491024   301 IQDKGPIVESYIGFIESYRDPFGSRGEFEGFVAVVNKAMSAKFERLVASAEQLLKELPWPPTFEKDKFLTPDFTSLDVLT 380
Cdd:pfam03571 152 VKDKGPVVETNIGFIETYRDPAGVRGEFEGFVAIVNKERSAKFGKLVDNAEKFIPLLPWPKDFEKDKFLKPDFTSLEVLT 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18491024   381 FAGSGIPAGINIPNYDDLRQTEGFKNVSLGNVLAVAYatQREKLTFLEEDDKDLYILWKGPSFDVQVGLHELLGHGSGKL 460
Cdd:pfam03571 232 FAGSGIPAGINIPNYDDIRQNEGFKNVSLGNVLSAKA--PNEKITFISEEDQELYKKYRDPAFEVQVGLHELLGHGSGKL 309

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18491024   461 FVQDEKGAFNFDQETVINPETGEQIQSWYRSGETWDSKFSTIASSYEECRAESVGLYLCLHPQVLEIFGFEGA-DAEDVI 539
Cdd:pfam03571 310 LQETADGKFNFDKENPPNPLTGKPITSWYKPGETWGSVFGSLASSYEECRAECVALYLSLNKEVLEIFGFTDKeEADDVI 389

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18491024   540 YVNWLNMVRAGLLALEFYTPEAFNWRQAHMQARFVILRVLLEAGE-GLVTITPTTGSDgrPDARVRLDRSKIRSVGKPAL 618
Cdd:pfam03571 390 YVNWLQMARAGLLALEFYDPETKKWGQAHMQARFAILKVLLEAGDaGFVKLEETKDED--SDLTIRLDRSKILTVGKPAI 467

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18491024   619 ERFLRRLQVLKSTGDVAGGRALYEGYATVTdappECFLTLRDTVLLRKESRKLIVQPNTRLEGSD-VQLLEYEASAAGLI 697
Cdd:pfam03571 468 GDFLLKLQVYKSTADVEAGTEFYEDYTTVD----EEFLKWRDIVLAKKQPRKVFVQANTVLNDGGkVELKEYEETPEGMI 543


                  ....*..
gi 18491024   698 RSFSERF 704
Cdd:pfam03571 544 QSFVERF 550
 
Name Accession Description Interval E-value
Peptidase_M49 pfam03571
Peptidase family M49;
143-704 0e+00

Peptidase family M49;


Pssm-ID: 460976  Cd Length: 550  Bit Score: 933.44  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18491024   143 LWQTCGELMFSLEPRLRHLGLGKEG-ITTYFSGN-CTMEDAKLAQDFLDSQNLSAYNTRLFKEVDGEgkpyYEVRLASVL 220
Cdd:pfam03571   1 LWEKVKDAIYSLDPRLLLLGFPSEGhVSTYYSGNdITKEEIEAVQKFLEKKGILPENTRLFKTSDGD----FEILVASNE 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18491024   221 GSEpsldsEVTSKLKSYEFRGSPFQVTRGDYAPILQKVVEQLEKAKAYAANSHQGQMLAQYIESFTQGSIEAHKRGSRFW 300
Cdd:pfam03571  77 ESE-----EYPEELETGEFNGKKVTLTYGDHSPELKKIVENLEKAKKYAANDTQKKMLEKYIESFETGSIEAHKDSQRHW 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18491024   301 IQDKGPIVESYIGFIESYRDPFGSRGEFEGFVAVVNKAMSAKFERLVASAEQLLKELPWPPTFEKDKFLTPDFTSLDVLT 380
Cdd:pfam03571 152 VKDKGPVVETNIGFIETYRDPAGVRGEFEGFVAIVNKERSAKFGKLVDNAEKFIPLLPWPKDFEKDKFLKPDFTSLEVLT 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18491024   381 FAGSGIPAGINIPNYDDLRQTEGFKNVSLGNVLAVAYatQREKLTFLEEDDKDLYILWKGPSFDVQVGLHELLGHGSGKL 460
Cdd:pfam03571 232 FAGSGIPAGINIPNYDDIRQNEGFKNVSLGNVLSAKA--PNEKITFISEEDQELYKKYRDPAFEVQVGLHELLGHGSGKL 309

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18491024   461 FVQDEKGAFNFDQETVINPETGEQIQSWYRSGETWDSKFSTIASSYEECRAESVGLYLCLHPQVLEIFGFEGA-DAEDVI 539
Cdd:pfam03571 310 LQETADGKFNFDKENPPNPLTGKPITSWYKPGETWGSVFGSLASSYEECRAECVALYLSLNKEVLEIFGFTDKeEADDVI 389

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18491024   540 YVNWLNMVRAGLLALEFYTPEAFNWRQAHMQARFVILRVLLEAGE-GLVTITPTTGSDgrPDARVRLDRSKIRSVGKPAL 618
Cdd:pfam03571 390 YVNWLQMARAGLLALEFYDPETKKWGQAHMQARFAILKVLLEAGDaGFVKLEETKDED--SDLTIRLDRSKILTVGKPAI 467

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18491024   619 ERFLRRLQVLKSTGDVAGGRALYEGYATVTdappECFLTLRDTVLLRKESRKLIVQPNTRLEGSD-VQLLEYEASAAGLI 697
Cdd:pfam03571 468 GDFLLKLQVYKSTADVEAGTEFYEDYTTVD----EEFLKWRDIVLAKKQPRKVFVQANTVLNDGGkVELKEYEETPEGMI 543


                  ....*..
gi 18491024   698 RSFSERF 704
Cdd:pfam03571 544 QSFVERF 550
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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