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Conserved domains on  [gi|5032019|ref|NP_005846|]
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receptor activity-modifying protein 1 isoform 1 precursor [Homo sapiens]

Protein Classification

receptor activity-modifying protein( domain architecture ID 10522662)

receptor activity-modifying protein (RAMP) such as human RAMP1, which transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane and acts as a receptor for calcitonin-gene-related peptide (CGRP) together with CALCRL

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RAMP pfam04901
Receptor activity modifying family; The calcitonin-receptor-like receptor can function as ...
 38-145 2.19e-66

Receptor activity modifying family; The calcitonin-receptor-like receptor can function as either a calcitonin-gene-related peptide or an adrenomedullin receptor. The receptors function is modified by receptor-activity-modifying protein or RAMP. RAMPs are single-transmembrane-domain proteins.


:

Pssm-ID: 461471  Cd Length: 109  Bit Score: 197.06  E-value: 2.19e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5032019     38 ELCLTQFQVDMEAVGETLWCDWGRTIRSYRELADCTWHMAEKLGCFWPNAEVDRFFLAVHGRYFRSCPISGRAVRDPPGS 117
Cdd:pfam04901   2 ELCLKQFKDDMEAIDKTLWCDWGEIIRPYSELTNCTELVAEKLGCYWPNPLVERFFVAIHRHYFSNCSLSGRALRDPPED 81

                          90       100
                  ....*....|....*....|....*...
gi 5032019    118 ILYPFIVVPITVTLLVTALVVWQSKRTE 145
Cdd:pfam04901  82 ILLPLIIVPICLTPLMVALVVWRSKRSE 109
 
Name Accession Description Interval E-value
RAMP pfam04901
Receptor activity modifying family; The calcitonin-receptor-like receptor can function as ...
 38-145 2.19e-66

Receptor activity modifying family; The calcitonin-receptor-like receptor can function as either a calcitonin-gene-related peptide or an adrenomedullin receptor. The receptors function is modified by receptor-activity-modifying protein or RAMP. RAMPs are single-transmembrane-domain proteins.


Pssm-ID: 461471  Cd Length: 109  Bit Score: 197.06  E-value: 2.19e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5032019     38 ELCLTQFQVDMEAVGETLWCDWGRTIRSYRELADCTWHMAEKLGCFWPNAEVDRFFLAVHGRYFRSCPISGRAVRDPPGS 117
Cdd:pfam04901   2 ELCLKQFKDDMEAIDKTLWCDWGEIIRPYSELTNCTELVAEKLGCYWPNPLVERFFVAIHRHYFSNCSLSGRALRDPPED 81

                          90       100
                  ....*....|....*....|....*...
gi 5032019    118 ILYPFIVVPITVTLLVTALVVWQSKRTE 145
Cdd:pfam04901  82 ILLPLIIVPICLTPLMVALVVWRSKRSE 109
 
Name Accession Description Interval E-value
RAMP pfam04901
Receptor activity modifying family; The calcitonin-receptor-like receptor can function as ...
 38-145 2.19e-66

Receptor activity modifying family; The calcitonin-receptor-like receptor can function as either a calcitonin-gene-related peptide or an adrenomedullin receptor. The receptors function is modified by receptor-activity-modifying protein or RAMP. RAMPs are single-transmembrane-domain proteins.


Pssm-ID: 461471  Cd Length: 109  Bit Score: 197.06  E-value: 2.19e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5032019     38 ELCLTQFQVDMEAVGETLWCDWGRTIRSYRELADCTWHMAEKLGCFWPNAEVDRFFLAVHGRYFRSCPISGRAVRDPPGS 117
Cdd:pfam04901   2 ELCLKQFKDDMEAIDKTLWCDWGEIIRPYSELTNCTELVAEKLGCYWPNPLVERFFVAIHRHYFSNCSLSGRALRDPPED 81

                          90       100
                  ....*....|....*....|....*...
gi 5032019    118 ILYPFIVVPITVTLLVTALVVWQSKRTE 145
Cdd:pfam04901  82 ILLPLIIVPICLTPLMVALVVWRSKRSE 109
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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