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Conserved domains on  [gi|5174465|ref|NP_006033|]
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heparan sulfate glucosamine 3-O-sulfotransferase 3A1 [Homo sapiens]

Protein Classification

sulfotransferase domain-containing protein( domain architecture ID 10464534)

sulfotransferase domain-containing protein such as mammalian sulfotransferases that utilize 3'-phospho-5'-adenylyl sulfate (PAPS) as the sulfonate donor to catalyze the sulfate conjugation of a variety of substrates including catecholamines, phenolic drugs, neurotransmitters, heparan, and estrogen, among others

CATH:  3.40.50.300
EC:  2.8.2.-
Gene Ontology:  GO:0008146
PubMed:  9360604|31270211
SCOP:  4003933

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
152-389 7.90e-46

Sulfotransferase domain;


:

Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 158.28  E-value: 7.90e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5174465    152 LPQAIIIGVKKGGTRALLEFLRVHPDVRAVGA--EPHFFD-RSYDKGLAWY-RDLMPRTLDGQITMEKTPS-YFVTREAP 226
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKseEPHLFNnHNRSPFLEWYpGDTYFDVAEGPVRLNALPSpRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5174465    227 AR---ISAMSKDTKLIVVVRDPVTRAISDYTQT----LSKRPDIPTFESLTFknrtaglidtSWSAIQIGIYAKHLEHWL 299
Cdd:pfam00685  81 LHllpKSLWDPNAKIIYLVRNPKDVAVSYYHFFrmakLLKAPGTPFEFVEDF----------LNGKVNCGSYFDHVKGWW 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5174465    300 RHFPIRQMLFVSGERLISDPAGELGRVQDFLGLKR-----IITDKHFYFNKTKGFPCLKKAE-----GSSRPHCLGKTKg 369
Cdd:pfam00685 151 KLRPPGNILFLRYEDLKKDPRGEIKKIAEFLGIPLteeelDKIVKHLSFENMKGNPCLNYSKlpkevSPFFRKGLVGDW- 229

                         250       260
                  ....*....|....*....|
gi 5174465    370 rtHPEIDREVVRRLREFYRP 389
Cdd:pfam00685 230 --KNYFTPEQAEKFDEIYQE 247
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
152-389 7.90e-46

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 158.28  E-value: 7.90e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5174465    152 LPQAIIIGVKKGGTRALLEFLRVHPDVRAVGA--EPHFFD-RSYDKGLAWY-RDLMPRTLDGQITMEKTPS-YFVTREAP 226
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKseEPHLFNnHNRSPFLEWYpGDTYFDVAEGPVRLNALPSpRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5174465    227 AR---ISAMSKDTKLIVVVRDPVTRAISDYTQT----LSKRPDIPTFESLTFknrtaglidtSWSAIQIGIYAKHLEHWL 299
Cdd:pfam00685  81 LHllpKSLWDPNAKIIYLVRNPKDVAVSYYHFFrmakLLKAPGTPFEFVEDF----------LNGKVNCGSYFDHVKGWW 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5174465    300 RHFPIRQMLFVSGERLISDPAGELGRVQDFLGLKR-----IITDKHFYFNKTKGFPCLKKAE-----GSSRPHCLGKTKg 369
Cdd:pfam00685 151 KLRPPGNILFLRYEDLKKDPRGEIKKIAEFLGIPLteeelDKIVKHLSFENMKGNPCLNYSKlpkevSPFFRKGLVGDW- 229

                         250       260
                  ....*....|....*....|
gi 5174465    370 rtHPEIDREVVRRLREFYRP 389
Cdd:pfam00685 230 --KNYFTPEQAEKFDEIYQE 247
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
152-389 7.90e-46

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 158.28  E-value: 7.90e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5174465    152 LPQAIIIGVKKGGTRALLEFLRVHPDVRAVGA--EPHFFD-RSYDKGLAWY-RDLMPRTLDGQITMEKTPS-YFVTREAP 226
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKseEPHLFNnHNRSPFLEWYpGDTYFDVAEGPVRLNALPSpRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5174465    227 AR---ISAMSKDTKLIVVVRDPVTRAISDYTQT----LSKRPDIPTFESLTFknrtaglidtSWSAIQIGIYAKHLEHWL 299
Cdd:pfam00685  81 LHllpKSLWDPNAKIIYLVRNPKDVAVSYYHFFrmakLLKAPGTPFEFVEDF----------LNGKVNCGSYFDHVKGWW 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5174465    300 RHFPIRQMLFVSGERLISDPAGELGRVQDFLGLKR-----IITDKHFYFNKTKGFPCLKKAE-----GSSRPHCLGKTKg 369
Cdd:pfam00685 151 KLRPPGNILFLRYEDLKKDPRGEIKKIAEFLGIPLteeelDKIVKHLSFENMKGNPCLNYSKlpkevSPFFRKGLVGDW- 229

                         250       260
                  ....*....|....*....|
gi 5174465    370 rtHPEIDREVVRRLREFYRP 389
Cdd:pfam00685 230 --KNYFTPEQAEKFDEIYQE 247
Sulfotransfer_3 pfam13469
Sulfotransferase family;
156-332 4.37e-17

Sulfotransferase family;


Pssm-ID: 463887  Cd Length: 173  Bit Score: 78.49  E-value: 4.37e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5174465    156 IIIGVKKGGTRALLEFLRVHPDVRAVGAEPHFFDRSYDKGLAWYRDL---MPRTLDGQITMEKTPSYFvtrEAPARISAM 232
Cdd:pfam13469   2 FIVGLPRSGTTLLHRLLAAHPDVRPPEETWFVIPRILALLQAWGKSLealARVPSYARWLCDKSPSHL---FHLDLLLKA 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5174465    233 SKDTKLIVVVRDPVTRAISDYTQTLSKrpDIPTFeSLTFKNRTAGLIDTsWSAIQIGIYAkhleHWLRHFPIRQmLFVSG 312
Cdd:pfam13469  79 FPDAKFIHLHRDPVDTVISSYCSLFGF--TLSSY-STAFLRDIGLALAR-WSRAYERLMA----ARARVPPGRF-LDVRY 149

                         170       180
                  ....*....|....*....|
gi 5174465    313 ERLISDPAGELGRVQDFLGL 332
Cdd:pfam13469 150 EDLVADPEGTLRRILEFLGL 169
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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