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Conserved domains on  [gi|5174641|ref|NP_006106|]
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melanoma antigen preferentially expressed in tumors isoform a [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1903219)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
SCOP:  4003523

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
RNA1 super family cl34950
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
349-437 9.94e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


The actual alignment was detected with superfamily member COG5238:

Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 41.70  E-value: 9.94e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5174641  349 SQLSVLSLSGVMLTDVSPEPLQALLERaSATLQDLVFDECGITDDQLLALLPSLSHCSQLTTLSFYGNSISISALQSLLQ 428
Cdd:COG5238 292 TTLTSLDLSVNRIGDEGAIALAEGLQG-NKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAK 370

                ....*....
gi 5174641  429 HLIGLSNLT 437
Cdd:COG5238 371 YLEGNTTLR 379
LRR super family cl34836
Leucine-rich repeat (LRR) protein [Transcription];
232-438 1.55e-03

Leucine-rich repeat (LRR) protein [Transcription];


The actual alignment was detected with superfamily member COG4886:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 41.07  E-value: 1.55e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5174641  232 LDSIEDLEVTCTWKLPTLAKFSPYLGQMINLRRLLLSHIhassyispekeeQYIAQFTS-QFLSLQCLQalyVDSLFFLR 310
Cdd:COG4886  68 LLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN------------EELSNLTNlESLDLSGNQ---LTDLPEEL 132
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5174641  311 GRLDQLlrhvmnplETLSITNCRLSEgdvmhLSQS-PSVSQLSVLSLSGVMLTDVsPEPLQALlerasATLQDLVFDECG 389
Cdd:COG4886 133 ANLTNL--------KELDLSNNQLTD-----LPEPlGNLTNLKSLDLSNNQLTDL-PEELGNL-----TNLKELDLSNNQ 193
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 5174641  390 ITDdqllaLLPSLSHCSQLTTLSFYGNSISisalqSLLQHLIGLSNLTH 438
Cdd:COG4886 194 ITD-----LPEPLGNLTNLEELDLSGNQLT-----DLPEPLANLTNLET 232
 
Name Accession Description Interval E-value
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
349-437 9.94e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 41.70  E-value: 9.94e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5174641  349 SQLSVLSLSGVMLTDVSPEPLQALLERaSATLQDLVFDECGITDDQLLALLPSLSHCSQLTTLSFYGNSISISALQSLLQ 428
Cdd:COG5238 292 TTLTSLDLSVNRIGDEGAIALAEGLQG-NKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAK 370

                ....*....
gi 5174641  429 HLIGLSNLT 437
Cdd:COG5238 371 YLEGNTTLR 379
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
232-438 1.55e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 41.07  E-value: 1.55e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5174641  232 LDSIEDLEVTCTWKLPTLAKFSPYLGQMINLRRLLLSHIhassyispekeeQYIAQFTS-QFLSLQCLQalyVDSLFFLR 310
Cdd:COG4886  68 LLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN------------EELSNLTNlESLDLSGNQ---LTDLPEEL 132
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5174641  311 GRLDQLlrhvmnplETLSITNCRLSEgdvmhLSQS-PSVSQLSVLSLSGVMLTDVsPEPLQALlerasATLQDLVFDECG 389
Cdd:COG4886 133 ANLTNL--------KELDLSNNQLTD-----LPEPlGNLTNLKSLDLSNNQLTDL-PEELGNL-----TNLKELDLSNNQ 193
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 5174641  390 ITDdqllaLLPSLSHCSQLTTLSFYGNSISisalqSLLQHLIGLSNLTH 438
Cdd:COG4886 194 ITD-----LPEPLGNLTNLEELDLSGNQLT-----DLPEPLANLTNLET 232
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
323-436 3.42e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 39.65  E-value: 3.42e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5174641  323 PLETLSITNCRLSEGDVMHLSQS--PSVSQLSVLSLSGVMLTDVSPEPLqALLERASATLQDLVFDECGITDDQLLALLP 400
Cdd:cd00116 109 SLQELKLNNNGLGDRGLRLLAKGlkDLPPALEKLVLGRNRLEGASCEAL-AKALRANRDLKELNLANNGIGDAGIRALAE 187
                        90       100       110
                ....*....|....*....|....*....|....*....
gi 5174641  401 SLSHCSQLTTLSFYGNSIS---ISALQSLLQHLIGLSNL 436
Cdd:cd00116 188 GLKANCNLEVLDLNNNGLTdegASALAETLASLKSLEVL 226
 
Name Accession Description Interval E-value
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
349-437 9.94e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 41.70  E-value: 9.94e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5174641  349 SQLSVLSLSGVMLTDVSPEPLQALLERaSATLQDLVFDECGITDDQLLALLPSLSHCSQLTTLSFYGNSISISALQSLLQ 428
Cdd:COG5238 292 TTLTSLDLSVNRIGDEGAIALAEGLQG-NKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAK 370

                ....*....
gi 5174641  429 HLIGLSNLT 437
Cdd:COG5238 371 YLEGNTTLR 379
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
341-437 1.13e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 41.31  E-value: 1.13e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5174641  341 HLSQSPSVSQLSvlsLSGVMLTDVSPEPL-QALLERASATLQDLVfDECgITDDQLLALLPSLSHCSQLTTLSFYGNSIS 419
Cdd:COG5238 203 ALTQNTTVTTLW---LKRNPIGDEGAEILaEALKGNKSLTTLDLS-NNQ-IGDEGVIALAEALKNNTTVETLYLSGNQIG 277
                        90
                ....*....|....*...
gi 5174641  420 ISALQSLLQHLIGLSNLT 437
Cdd:COG5238 278 AEGAIALAKALQGNTTLT 295
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
232-438 1.55e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 41.07  E-value: 1.55e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5174641  232 LDSIEDLEVTCTWKLPTLAKFSPYLGQMINLRRLLLSHIhassyispekeeQYIAQFTS-QFLSLQCLQalyVDSLFFLR 310
Cdd:COG4886  68 LLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN------------EELSNLTNlESLDLSGNQ---LTDLPEEL 132
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5174641  311 GRLDQLlrhvmnplETLSITNCRLSEgdvmhLSQS-PSVSQLSVLSLSGVMLTDVsPEPLQALlerasATLQDLVFDECG 389
Cdd:COG4886 133 ANLTNL--------KELDLSNNQLTD-----LPEPlGNLTNLKSLDLSNNQLTDL-PEELGNL-----TNLKELDLSNNQ 193
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 5174641  390 ITDdqllaLLPSLSHCSQLTTLSFYGNSISisalqSLLQHLIGLSNLTH 438
Cdd:COG4886 194 ITD-----LPEPLGNLTNLEELDLSGNQLT-----DLPEPLANLTNLET 232
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
323-436 3.42e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 39.65  E-value: 3.42e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5174641  323 PLETLSITNCRLSEGDVMHLSQS--PSVSQLSVLSLSGVMLTDVSPEPLqALLERASATLQDLVFDECGITDDQLLALLP 400
Cdd:cd00116 109 SLQELKLNNNGLGDRGLRLLAKGlkDLPPALEKLVLGRNRLEGASCEAL-AKALRANRDLKELNLANNGIGDAGIRALAE 187
                        90       100       110
                ....*....|....*....|....*....|....*....
gi 5174641  401 SLSHCSQLTTLSFYGNSIS---ISALQSLLQHLIGLSNL 436
Cdd:cd00116 188 GLKANCNLEVLDLNNNGLTdegASALAETLASLKSLEVL 226
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
324-475 5.52e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 39.15  E-value: 5.52e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5174641  324 LETLSITNCRLSEGDvMHLSQSPSvsqLSVLSLSGVMLTDVsPEPLQAL--LE--RASAT-------------LQDLVFD 386
Cdd:COG4886 184 LKELDLSNNQITDLP-EPLGNLTN---LEELDLSGNQLTDL-PEPLANLtnLEtlDLSNNqltdlpelgnltnLEELDLS 258
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5174641  387 ECGITDdqllalLPSLSHCSQLTTLSFYGNSISISALQSLLQHLIGLSNLTHVLYPVPLESYEDIHGTLHLERLAYLHAR 466
Cdd:COG4886 259 NNQLTD------LPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKG 332

                ....*....
gi 5174641  467 LRELLCELG 475
Cdd:COG4886 333 LLVTLTTLA 341
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
294-419 8.12e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 37.84  E-value: 8.12e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5174641  294 SLQCLQALYVD--SLFFLRGrLDQLlrhvmNPLETLSITNCRLSEGDVMH------LSQSPSvsqLSVLSLSGVMLTDVS 365
Cdd:cd21340  66 NLVNLKKLYLGgnRISVVEG-LENL-----TNLEELHIENQRLPPGEKLTfdprslAALSNS---LRVLNISGNNIDSLE 136
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 5174641  366 P-EPLQALlerasatlQDLVFDECGITDdqLLALLPSLSHCSQLTTLSFYGNSIS 419
Cdd:cd21340 137 PlAPLRNL--------EQLDASNNQISD--LEELLDLLSSWPSLRELDLTGNPVC 181
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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