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Conserved domains on  [gi|22907052|ref|NP_006400|]
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actin-related protein 2/3 complex subunit 1A isoform 1 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
15-266 4.78e-18

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 84.58  E-value: 4.78e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907052  15 AWNRDRTQIALSPNNHEVHIYkkNGSQWVKAHELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWSQKDGvwKPTLVILR 94
Cdd:COG2319 127 AFSPDGKTLASGSADGTVRLW--DLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG--KLLRTLTG 202

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907052  95 INRAATFVKWSPLENKFAVGSGARLISVcyfesendWWVSKhiKKPIR------STVLSLDWHPNNVLLAAGSCDFKCRV 168
Cdd:COG2319 203 HTGAVRSVAFSPDGKLLASGSADGTVRL--------WDLAT--GKLLRtltghsGSVRSVAFSPDGRLLASGSADGTVRL 272

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907052 169 FSAyikevdekpaSTpwgskmpfGQLMSEFGGSGtgGWVHGVSFSASGSRLAWVSHDSTVSVADASKSVQVSTLKTEFLP 248
Cdd:COG2319 273 WDL----------AT--------GELLRTLTGHS--GGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGA 332

                       250
                ....*....|....*...
gi 22907052 249 LLSVSFVSENSVVAAGHD 266
Cdd:COG2319 333 VRSVAFSPDGKTLASGSD 350
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
15-266 4.78e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 84.58  E-value: 4.78e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907052  15 AWNRDRTQIALSPNNHEVHIYkkNGSQWVKAHELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWSQKDGvwKPTLVILR 94
Cdd:COG2319 127 AFSPDGKTLASGSADGTVRLW--DLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG--KLLRTLTG 202

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907052  95 INRAATFVKWSPLENKFAVGSGARLISVcyfesendWWVSKhiKKPIR------STVLSLDWHPNNVLLAAGSCDFKCRV 168
Cdd:COG2319 203 HTGAVRSVAFSPDGKLLASGSADGTVRL--------WDLAT--GKLLRtltghsGSVRSVAFSPDGRLLASGSADGTVRL 272

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907052 169 FSAyikevdekpaSTpwgskmpfGQLMSEFGGSGtgGWVHGVSFSASGSRLAWVSHDSTVSVADASKSVQVSTLKTEFLP 248
Cdd:COG2319 273 WDL----------AT--------GELLRTLTGHS--GGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGA 332

                       250
                ....*....|....*...
gi 22907052 249 LLSVSFVSENSVVAAGHD 266
Cdd:COG2319 333 VRSVAFSPDGKTLASGSD 350
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 46-288 8.84e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 76.60  E-value: 8.84e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907052  46 HELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWSQKDGVWKPTLVILRInrAATFVKWSPLENKFAVGSGARLISVcyf 125
Cdd:cd00200   3 RTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTG--PVRDVAASADGTYLASGSSDKTIRL--- 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907052 126 esendWWVSKhiKKPIR------STVLSLDWHPNNVLLAAGSCDFKCRVFSayikevdekpastpwgskMPFGQLMSEFg 199
Cdd:cd00200  78 -----WDLET--GECVRtltghtSYVSSVAFSPDGRILSSSSRDKTIKVWD------------------VETGKCLTTL- 131

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907052 200 gSGTGGWVHGVSFSASGSRLAWVSHDSTVSVADASKSVQVSTLKTEFLPLLSVSFV-SENSVVAAGHDCCPMLFNYDDRG 278
Cdd:cd00200 132 -RGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSpDGEKLLSSSSDGTIKLWDLSTGK 210

                       250
                ....*....|.
gi 22907052 279 CL-TFVSKLDI 288
Cdd:cd00200 211 CLgTLRGHENG 221
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 46-80 9.64e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.22  E-value: 9.64e-05
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 22907052     46 HELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWS 80
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
42-80 5.86e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 5.86e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 22907052    42 WVKAHELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWS 80
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
15-266 4.78e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 84.58  E-value: 4.78e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907052  15 AWNRDRTQIALSPNNHEVHIYkkNGSQWVKAHELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWSQKDGvwKPTLVILR 94
Cdd:COG2319 127 AFSPDGKTLASGSADGTVRLW--DLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG--KLLRTLTG 202

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907052  95 INRAATFVKWSPLENKFAVGSGARLISVcyfesendWWVSKhiKKPIR------STVLSLDWHPNNVLLAAGSCDFKCRV 168
Cdd:COG2319 203 HTGAVRSVAFSPDGKLLASGSADGTVRL--------WDLAT--GKLLRtltghsGSVRSVAFSPDGRLLASGSADGTVRL 272

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907052 169 FSAyikevdekpaSTpwgskmpfGQLMSEFGGSGtgGWVHGVSFSASGSRLAWVSHDSTVSVADASKSVQVSTLKTEFLP 248
Cdd:COG2319 273 WDL----------AT--------GELLRTLTGHS--GGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGA 332

                       250
                ....*....|....*...
gi 22907052 249 LLSVSFVSENSVVAAGHD 266
Cdd:COG2319 333 VRSVAFSPDGKTLASGSD 350
WD40 COG2319
WD40 repeat [General function prediction only];
9-264 2.45e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 79.57  E-value: 2.45e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907052   9 EPITCHAWNRDRTQIALSPNNHEVHIYKKNGSQWVkaHELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWSQKDGvwKP 88
Cdd:COG2319 163 GAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLL--RTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATG--KL 238

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907052  89 TLVILRINRAATFVKWSPLENKFAVGSGARLISVcyfesendWWVS----KHIKKPIRSTVLSLDWHPNNVLLAAGSCDF 164
Cdd:COG2319 239 LRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRL--------WDLAtgelLRTLTGHSGGVNSVAFSPDGKLLASGSDDG 310

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907052 165 KCRVFSAyikevdekpaSTpwgskmpfGQLMSEFggSGTGGWVHGVSFSASGSRLAWVSHDSTVSVADASKSVQVSTLKT 244
Cdd:COG2319 311 TVRLWDL----------AT--------GKLLRTL--TGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTG 370

                       250       260
                ....*....|....*....|
gi 22907052 245 EFLPLLSVSFVSENSVVAAG 264
Cdd:COG2319 371 HTGAVTSVAFSPDGRTLASG 390
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 46-288 8.84e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 76.60  E-value: 8.84e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907052  46 HELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWSQKDGVWKPTLVILRInrAATFVKWSPLENKFAVGSGARLISVcyf 125
Cdd:cd00200   3 RTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTG--PVRDVAASADGTYLASGSSDKTIRL--- 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907052 126 esendWWVSKhiKKPIR------STVLSLDWHPNNVLLAAGSCDFKCRVFSayikevdekpastpwgskMPFGQLMSEFg 199
Cdd:cd00200  78 -----WDLET--GECVRtltghtSYVSSVAFSPDGRILSSSSRDKTIKVWD------------------VETGKCLTTL- 131

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907052 200 gSGTGGWVHGVSFSASGSRLAWVSHDSTVSVADASKSVQVSTLKTEFLPLLSVSFV-SENSVVAAGHDCCPMLFNYDDRG 278
Cdd:cd00200 132 -RGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSpDGEKLLSSSSDGTIKLWDLSTGK 210

                       250
                ....*....|.
gi 22907052 279 CL-TFVSKLDI 288
Cdd:cd00200 211 CLgTLRGHENG 221
WD40 COG2319
WD40 repeat [General function prediction only];
15-266 2.26e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 76.87  E-value: 2.26e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907052  15 AWNRDRTQIALSPNNHEVHIYKKNGSQWVkaHELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWSQKDGvwKPTLVILR 94
Cdd:COG2319  85 AFSPDGRLLASASADGTVRLWDLATGLLL--RTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATG--KLLRTLTG 160

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907052  95 INRAATFVKWSPLENKFAVGSGARLISVcyfesendWWVSKhiKKPIRS------TVLSLDWHPNNVLLAAGSCDFKCRV 168
Cdd:COG2319 161 HSGAVTSVAFSPDGKLLASGSDDGTVRL--------WDLAT--GKLLRTltghtgAVRSVAFSPDGKLLASGSADGTVRL 230

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907052 169 FSayikevdekpASTpwgskmpfGQLMSEFGGSgtGGWVHGVSFSASGSRLAWVSHDSTVSVADASKSVQVSTLKTEFLP 248
Cdd:COG2319 231 WD----------LAT--------GKLLRTLTGH--SGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGG 290

                       250
                ....*....|....*...
gi 22907052 249 LLSVSFVSENSVVAAGHD 266
Cdd:COG2319 291 VNSVAFSPDGKLLASGSD 308
WD40 COG2319
WD40 repeat [General function prediction only];
15-234 6.64e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 75.33  E-value: 6.64e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907052  15 AWNRDRTQIALSPNNHEVHIYKKNGSQWVkaHELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWSQKDGVWKPTLVilR 94
Cdd:COG2319 211 AFSPDGKLLASGSADGTVRLWDLATGKLL--RTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLT--G 286

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907052  95 INRAATFVKWSPLENKFAVGSGARLISVcyfesendWWVSKhiKKPIRS------TVLSLDWHPNNVLLAAGSCDFKCRV 168
Cdd:COG2319 287 HSGGVNSVAFSPDGKLLASGSDDGTVRL--------WDLAT--GKLLRTltghtgAVRSVAFSPDGKTLASGSDDGTVRL 356

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 22907052 169 FSAyikevdekpastpwgskmPFGQLMSEFggSGTGGWVHGVSFSASGSRLAWVSHDSTVSVADAS 234
Cdd:COG2319 357 WDL------------------ATGELLRTL--TGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 10-268 4.87e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 62.74  E-value: 4.87e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907052  10 PITCHAWNRDRTQIALSPNNHEVHIYKKNGSQwvKAHELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWSQKDGvwKPT 89
Cdd:cd00200  53 PVRDVAASADGTYLASGSSDKTIRLWDLETGE--CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETG--KCL 128

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907052  90 LVILRINRAATFVKWSPlENKFAVGSGA-RLISVCYFESEndwwvskhikKPIR------STVLSLDWHPNNVLLAAGSC 162
Cdd:cd00200 129 TTLRGHTDWVNSVAFSP-DGTFVASSSQdGTIKLWDLRTG----------KCVAtltghtGEVNSVAFSPDGEKLLSSSS 197

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907052 163 DFKCRVFSayikevdekpastpwgskMPFGQLMSEFGGSgtGGWVHGVSFSASGSRLAWVSHDSTVSVADASKSVQVSTL 242
Cdd:cd00200 198 DGTIKLWD------------------LSTGKCLGTLRGH--ENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTL 257

                       250       260
                ....*....|....*....|....*..
gi 22907052 243 KTEFLPLLSVSFVSENSVVAAG-HDCC 268
Cdd:cd00200 258 SGHTNSVTSLAWSPDGKRLASGsADGT 284
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 10-170 4.43e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 60.04  E-value: 4.43e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907052  10 PITCHAWNRDRTQIALSPNNHEVHIYkkNGSQWVKAHELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWSQKDGVWKPT 89
Cdd:cd00200 137 WVNSVAFSPDGTFVASSSQDGTIKLW--DLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGT 214

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907052  90 LVilRINRAATFVKWSPLENKFAVGSGARLISVcyfesendW-WVSKHIKKPIR---STVLSLDWHPNNVLLAAGSCDFK 165
Cdd:cd00200 215 LR--GHENGVNSVAFSPDGYLLASGSEDGTIRV--------WdLRTGECVQTLSghtNSVTSLAWSPDGKRLASGSADGT 284


                ....*
gi 22907052 166 CRVFS 170
Cdd:cd00200 285 IRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 9-230 8.59e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 58.89  E-value: 8.59e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907052   9 EPITCHAWNRDRTQIALSPNNHEVHIYkkNGSQWVKAHELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWSQKDGvwKP 88
Cdd:cd00200  94 SYVSSVAFSPDGRILSSSSRDKTIKVW--DVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTG--KC 169

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907052  89 TLVILRINRAATFVKWSPLENKFAVGSGARLI---------SVCYFESENDWwvskhikkpirstVLSLDWHPNNVLLAA 159
Cdd:cd00200 170 VATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIklwdlstgkCLGTLRGHENG-------------VNSVAFSPDGYLLAS 236

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 22907052 160 GSCDFKCRVFSAYIkevdekpastpwgskmpfGQLMSEFggSGTGGWVHGVSFSASGSRLAWVSHDSTVSV 230
Cdd:cd00200 237 GSEDGTIRVWDLRT------------------GECVQTL--SGHTNSVTSLAWSPDGKRLASGSADGTIRI 287
WD40 COG2319
WD40 repeat [General function prediction only];
59-266 5.81e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 44.90  E-value: 5.81e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907052  59 DWAPKSDRIVTCGADRNAYVWSQKDGVWKPTLVILRinRAATFVKWSPLENKFAVGSGARLISVcyfeSENDWWVSKHIK 138
Cdd:COG2319   1 ALSADGAALAAASADLALALLAAALGALLLLLLGLA--AAVASLAASPDGARLAAGAGDLTLLL----LDAAAGALLATL 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22907052 139 KPIRSTVLSLDWHPNNVLLAAGSCDFKCRVFSAyikeVDEKPASTPWGskmpfgqlmsefggsgTGGWVHGVSFSASGSR 218
Cdd:COG2319  75 LGHTAAVLSVAFSPDGRLLASASADGTVRLWDL----ATGLLLRTLTG----------------HTGAVRSVAFSPDGKT 134

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 22907052 219 LAWVSHDSTVSVADASKSVQVSTLKTEFLPLLSVSFVSENSVVAAGHD 266
Cdd:COG2319 135 LASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSD 182
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 46-80 9.64e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.22  E-value: 9.64e-05
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 22907052     46 HELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWS 80
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
42-80 5.86e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 5.86e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 22907052    42 WVKAHELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWS 80
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 9-80 9.23e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 37.70  E-value: 9.23e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 22907052   9 EPITCHAWNRDRTQIALSPNNHEVHIYkkNGSQWVKAHELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWS 80
Cdd:cd00200 220 NGVNSVAFSPDGYLLASGSEDGTIRVW--DLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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