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Conserved domains on  [gi|28830308|ref|NP_006579|]
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sulfotransferase 1C4 isoform 1 [Homo sapiens]

Protein Classification

sulfotransferase domain-containing protein( domain architecture ID 10464534)

sulfotransferase domain-containing protein such as mammalian sulfotransferases that utilize 3'-phospho-5'-adenylyl sulfate (PAPS) as the sulfonate donor to catalyze the sulfate conjugation of a variety of substrates including catecholamines, phenolic drugs, neurotransmitters, heparan, and estrogen, among others

CATH:  3.40.50.300
EC:  2.8.2.-
Gene Ontology:  GO:0008146
PubMed:  9360604|31270211
SCOP:  4003933

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
45-294 4.89e-118

Sulfotransferase domain;


:

Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 339.70  E-value: 4.89e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28830308    45 PDDLLISTYPKAGTTWTQEIVELIQNEGDVEKSKRAPT---HQRFPFLEM----KIPSLGSGLEQAHAMPSPRILKTHLP 117
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKSEEPHLfnnHNRSPFLEWypgdTYFDVAEGPVRLNALPSPRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28830308   118 FHLLPPSLLEKNCKIIYVARNPKDNMVSYYHFQRMNKALPAPGTWEEYFETFLAGKVCWGSWHEHVKGWWEAKDKHRILY 197
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28830308   198 LFYEDMKKNPKHEIQKLAEFIGKKLDDKVLDKIVHYTSFDVMKQNPMANYSSIPAEimdhsISPFMRKGAVGDWKKHFTV 277
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLPKE-----VSPFFRKGLVGDWKNYFTP 235

                         250
                  ....*....|....*..
gi 28830308   278 AQNERFDEDYKKKMTDT 294
Cdd:pfam00685 236 EQAEKFDEIYQEKMKGT 252
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
45-294 4.89e-118

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 339.70  E-value: 4.89e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28830308    45 PDDLLISTYPKAGTTWTQEIVELIQNEGDVEKSKRAPT---HQRFPFLEM----KIPSLGSGLEQAHAMPSPRILKTHLP 117
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKSEEPHLfnnHNRSPFLEWypgdTYFDVAEGPVRLNALPSPRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28830308   118 FHLLPPSLLEKNCKIIYVARNPKDNMVSYYHFQRMNKALPAPGTWEEYFETFLAGKVCWGSWHEHVKGWWEAKDKHRILY 197
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28830308   198 LFYEDMKKNPKHEIQKLAEFIGKKLDDKVLDKIVHYTSFDVMKQNPMANYSSIPAEimdhsISPFMRKGAVGDWKKHFTV 277
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLPKE-----VSPFFRKGLVGDWKNYFTP 235

                         250
                  ....*....|....*..
gi 28830308   278 AQNERFDEDYKKKMTDT 294
Cdd:pfam00685 236 EQAEKFDEIYQEKMKGT 252
PLN02164 PLN02164
sulfotransferase
 41-299 6.42e-39

sulfotransferase


Pssm-ID: 177822  Cd Length: 346  Bit Score: 140.06  E-value: 6.42e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28830308   41 FQAKPDDLLISTYPKAGTTWTQEIVELIQNEGDVEKS-----KRAPtHQRFPFLEMKIPSLgsgleqahamPSPRILK-- 113
Cdd:PLN02164  75 FQARPNDFLVCSYPKTGTTWLKALTFAIANRSRFDDSsnpllKRNP-HEFVPYIEIDFPFF----------PSVDVLKdk 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28830308  114 ------THLPFHLLPPSLLEKNCKIIYVARNPKDNMVSYYHFQRMNKALPAP-GTWEEYFETFLAGKVCWGSWHEHVKGW 186
Cdd:PLN02164 144 gntlfsTHIPYGLLPDSVVKSGCKMVYIWRDPKDTFISMWTFLHKERSQQGPlNSLEESFDMFCRGLSVYGPYLDHVLGY 223

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28830308  187 WEA--KDKHRILYLFYEDMKKNPKHEIQKLAEFIGKKLDDK-----VLDKIVHYTSFDVMKqNPMANYSSIPAEIMD--H 257
Cdd:PLN02164 224 WKAyqENPDRILFLKYETMRADPLPYVKRLAEFMGYGFTAEeeekgVVEKVVKLCSFETLK-NLEANKGEKDREDRPavY 302

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 28830308  258 SISPFMRKGAVGDWKKHFTVAQNERFDEDYKKKMTDTRLTFH 299
Cdd:PLN02164 303 ANSAYFRKGKVGDWQNYLTPEMAARIDGLMEEKFKGTGLLEH 344
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
45-294 4.89e-118

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 339.70  E-value: 4.89e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28830308    45 PDDLLISTYPKAGTTWTQEIVELIQNEGDVEKSKRAPT---HQRFPFLEM----KIPSLGSGLEQAHAMPSPRILKTHLP 117
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKSEEPHLfnnHNRSPFLEWypgdTYFDVAEGPVRLNALPSPRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28830308   118 FHLLPPSLLEKNCKIIYVARNPKDNMVSYYHFQRMNKALPAPGTWEEYFETFLAGKVCWGSWHEHVKGWWEAKDKHRILY 197
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28830308   198 LFYEDMKKNPKHEIQKLAEFIGKKLDDKVLDKIVHYTSFDVMKQNPMANYSSIPAEimdhsISPFMRKGAVGDWKKHFTV 277
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLPKE-----VSPFFRKGLVGDWKNYFTP 235

                         250
                  ....*....|....*..
gi 28830308   278 AQNERFDEDYKKKMTDT 294
Cdd:pfam00685 236 EQAEKFDEIYQEKMKGT 252
PLN02164 PLN02164
sulfotransferase
 41-299 6.42e-39

sulfotransferase


Pssm-ID: 177822  Cd Length: 346  Bit Score: 140.06  E-value: 6.42e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28830308   41 FQAKPDDLLISTYPKAGTTWTQEIVELIQNEGDVEKS-----KRAPtHQRFPFLEMKIPSLgsgleqahamPSPRILK-- 113
Cdd:PLN02164  75 FQARPNDFLVCSYPKTGTTWLKALTFAIANRSRFDDSsnpllKRNP-HEFVPYIEIDFPFF----------PSVDVLKdk 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28830308  114 ------THLPFHLLPPSLLEKNCKIIYVARNPKDNMVSYYHFQRMNKALPAP-GTWEEYFETFLAGKVCWGSWHEHVKGW 186
Cdd:PLN02164 144 gntlfsTHIPYGLLPDSVVKSGCKMVYIWRDPKDTFISMWTFLHKERSQQGPlNSLEESFDMFCRGLSVYGPYLDHVLGY 223

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28830308  187 WEA--KDKHRILYLFYEDMKKNPKHEIQKLAEFIGKKLDDK-----VLDKIVHYTSFDVMKqNPMANYSSIPAEIMD--H 257
Cdd:PLN02164 224 WKAyqENPDRILFLKYETMRADPLPYVKRLAEFMGYGFTAEeeekgVVEKVVKLCSFETLK-NLEANKGEKDREDRPavY 302

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 28830308  258 SISPFMRKGAVGDWKKHFTVAQNERFDEDYKKKMTDTRLTFH 299
Cdd:PLN02164 303 ANSAYFRKGKVGDWQNYLTPEMAARIDGLMEEKFKGTGLLEH 344
Sulfotransfer_3 pfam13469
Sulfotransferase family;
54-224 1.42e-07

Sulfotransferase family;


Pssm-ID: 463887  Cd Length: 173  Bit Score: 50.37  E-value: 1.42e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28830308    54 PKAGTTWTQEIVeliqnegDVEKSKRAPTHQRF--PFLEMKIPSLGSGLEQAHAMPSP-RILKTHLPFHLLPPSLLEK-- 128
Cdd:pfam13469   7 PRSGTTLLHRLL-------AAHPDVRPPEETWFviPRILALLQAWGKSLEALARVPSYaRWLCDKSPSHLFHLDLLLKaf 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28830308   129 -NCKIIYVARNPKDNMVSyyHFQRMNKALPAPgtWEEYFETFLAGKVCWgsWHEHVKGWWEAKDKH---RILYLFYEDMK 204
Cdd:pfam13469  80 pDAKFIHLHRDPVDTVIS--SYCSLFGFTLSS--YSTAFLRDIGLALAR--WSRAYERLMAARARVppgRFLDVRYEDLV 153

                         170       180
                  ....*....|....*....|
gi 28830308   205 KNPKHEIQKLAEFIGKKLDD 224
Cdd:pfam13469 154 ADPEGTLRRILEFLGLPWDD 173
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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