|
Name |
Accession |
Description |
Interval |
E-value |
| Tryp_SPc |
cd00190 |
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens ... |
445-682 |
1.13e-79 |
|
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad residues. :
Pssm-ID: 238113 [Multi-domain] Cd Length: 232 Bit Score: 252.97 E-value: 1.13e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264363 445 IYGGQKAKPGDFPWQVLI---LGGTTAAGALLYDNWVLTAAHAVYEQkhDASALDIRMGTLKRLSPHYTQ--AWSEAVFI 519
Cdd:cd00190 1 IVGGSEAKIGSFPWQVSLqytGGRHFCGGSLISPRWVLTAAHCVYSS--APSNYTVRLGSHDLSSNEGGGqvIKVKKVIV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264363 520 HEGYtHDAGFDNDIALIKLNNKVVINSNITPICLPRKEAEsfMRTDDIGTASGWGLTQ-RGFLARNLMYVDIPIVDHQKC 598
Cdd:cd00190 79 HPNY-NPSTYDNDIALLKLKRPVTLSDNVRPICLPSSGYN--LPAGTTCTVSGWGRTSeGGPLPDVLQEVNVPIVSNAEC 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264363 599 TAAYEKPPYprgsVTANMLCAGLESGGKDSCRGDSGGALVFLDseTERWFVGGIVSWGSmNCGEAGQYGVYTKVINYIPW 678
Cdd:cd00190 156 KRAYSYGGT----ITDNMLCAGGLEGGKDACQGDSGGPLVCND--NGRGVLVGIVSWGS-GCARPNYPGVYTRVSSYLDW 228
|
....
gi 21264363 679 IENI 682
Cdd:cd00190 229 IQKT 232
|
|
| CUB |
pfam00431 |
CUB domain; |
184-293 |
1.45e-31 |
|
CUB domain; :
Pssm-ID: 395345 [Multi-domain] Cd Length: 110 Bit Score: 118.55 E-value: 1.45e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264363 184 CSGqVFTQRSGELSSPEYPRPYPKLSSCTYSISLEEGFSVILDFvESFDVETHPEtlCPYDFLKIQTDREE----HGPFC 259
Cdd:pfam00431 1 CGG-VLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTF-QDFELEDHDE--CGYDYVEIRDGPSAssplLGRFC 76
|
90 100 110
....*....|....*....|....*....|....
gi 21264363 260 GKTLPHRIETKSNTVTITFVTDESGDHTGWKIHY 293
Cdd:pfam00431 77 GSGIPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
|
|
| CUB |
smart00042 |
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ... |
28-134 |
1.40e-27 |
|
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain. :
Pssm-ID: 214483 [Multi-domain] Cd Length: 102 Bit Score: 107.09 E-value: 1.40e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264363 28 GRLASPGFPGEYANDQERRWTLTAPPGYRLRLYFTHFDLELSHLCEYDFVKLSSG----AKVLATLCGQEstdteraPGK 103
Cdd:smart00042 1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYDGpsasSPLLGRFCGSE-------APP 73
|
90 100 110
....*....|....*....|....*....|.
gi 21264363 104 DTFYSLGSSLDITFRSDYSNEKpfTGFEAFY 134
Cdd:smart00042 74 PVISSSSNSLTLTFVSDSSVQK--RGFSARY 102
|
|
| CCP |
smart00032 |
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ... |
300-361 |
7.30e-10 |
|
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII. :
Pssm-ID: 214478 [Multi-domain] Cd Length: 56 Bit Score: 55.23 E-value: 7.30e-10
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 21264363 300 CPYPMAPPNGHVSPVQAKYILKDSFSIFCETGYELLQghlplkSFTAVCQKDGSWDRPMPAC 361
Cdd:smart00032 1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIG------SSTITCLENGTWSPPPPTC 56
|
|
| Sushi |
pfam00084 |
Sushi repeat (SCR repeat); |
366-430 |
3.52e-07 |
|
Sushi repeat (SCR repeat); :
Pssm-ID: 459664 [Multi-domain] Cd Length: 56 Bit Score: 47.49 E-value: 3.52e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 21264363 366 CGPPDDLPSGRVEYITGPgvTTYKAVIQYSCEETFYTMKVNdgKYVCEADGFWTSSKgekslPVC 430
Cdd:pfam00084 1 CPPPPDIPNGKVSATKNE--YNYGASVSYECDPGYRLVGSP--TITCQEDGTWSPPF-----PEC 56
|
|
| FXa_inhibition |
pfam14670 |
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ... |
152-180 |
2.90e-06 |
|
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442. :
Pssm-ID: 464251 [Multi-domain] Cd Length: 36 Bit Score: 44.16 E-value: 2.90e-06
10 20
....*....|....*....|....*....
gi 21264363 152 CDHHCHNHLGGFYCSCRAGYVLHRNKRTC 180
Cdd:pfam14670 8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
|
|
|
|
Name |
Accession |
Description |
Interval |
E-value |
| Tryp_SPc |
cd00190 |
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens ... |
445-682 |
1.13e-79 |
|
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad residues.
Pssm-ID: 238113 [Multi-domain] Cd Length: 232 Bit Score: 252.97 E-value: 1.13e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264363 445 IYGGQKAKPGDFPWQVLI---LGGTTAAGALLYDNWVLTAAHAVYEQkhDASALDIRMGTLKRLSPHYTQ--AWSEAVFI 519
Cdd:cd00190 1 IVGGSEAKIGSFPWQVSLqytGGRHFCGGSLISPRWVLTAAHCVYSS--APSNYTVRLGSHDLSSNEGGGqvIKVKKVIV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264363 520 HEGYtHDAGFDNDIALIKLNNKVVINSNITPICLPRKEAEsfMRTDDIGTASGWGLTQ-RGFLARNLMYVDIPIVDHQKC 598
Cdd:cd00190 79 HPNY-NPSTYDNDIALLKLKRPVTLSDNVRPICLPSSGYN--LPAGTTCTVSGWGRTSeGGPLPDVLQEVNVPIVSNAEC 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264363 599 TAAYEKPPYprgsVTANMLCAGLESGGKDSCRGDSGGALVFLDseTERWFVGGIVSWGSmNCGEAGQYGVYTKVINYIPW 678
Cdd:cd00190 156 KRAYSYGGT----ITDNMLCAGGLEGGKDACQGDSGGPLVCND--NGRGVLVGIVSWGS-GCARPNYPGVYTRVSSYLDW 228
|
....
gi 21264363 679 IENI 682
Cdd:cd00190 229 IQKT 232
|
|
| Tryp_SPc |
smart00020 |
Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens ... |
444-679 |
9.87e-79 |
|
Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. A few, however, are active as single chain molecules, and others are inactive due to substitutions of the catalytic triad residues.
Pssm-ID: 214473 Cd Length: 229 Bit Score: 250.67 E-value: 9.87e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264363 444 RIYGGQKAKPGDFPWQVLIL---GGTTAAGALLYDNWVLTAAHAVYeqKHDASALDIRMGTLKRLSPHYTQAWS-EAVFI 519
Cdd:smart00020 1 RIVGGSEANIGSFPWQVSLQyggGRHFCGGSLISPRWVLTAAHCVR--GSDPSNIRVRLGSHDLSSGEEGQVIKvSKVII 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264363 520 HEGYtHDAGFDNDIALIKLNNKVVINSNITPICLPRKEaeSFMRTDDIGTASGWGLTQ--RGFLARNLMYVDIPIVDHQK 597
Cdd:smart00020 79 HPNY-NPSTYDNDIALLKLKEPVTLSDNVRPICLPSSN--YNVPAGTTCTVSGWGRTSegAGSLPDTLQEVNVPIVSNAT 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264363 598 CTAAYekppYPRGSVTANMLCAGLESGGKDSCRGDSGGALVFLDsetERWFVGGIVSWGSmNCGEAGQYGVYTKVINYIP 677
Cdd:smart00020 156 CRRAY----SGGGAITDNMLCAGGLEGGKDACQGDSGGPLVCND---GRWVLVGIVSWGS-GCARPGKPGVYTRVSSYLD 227
|
..
gi 21264363 678 WI 679
Cdd:smart00020 228 WI 229
|
|
| Trypsin |
pfam00089 |
Trypsin; |
445-679 |
4.25e-55 |
|
Trypsin;
Pssm-ID: 459667 [Multi-domain] Cd Length: 219 Bit Score: 187.65 E-value: 4.25e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264363 445 IYGGQKAKPGDFPWQVLIL---GGTTAAGALLYDNWVLTAAHAVYeqkhDASALDIRMG--TLKRLSPHYTQAWSEAVFI 519
Cdd:pfam00089 1 IVGGDEAQPGSFPWQVSLQlssGKHFCGGSLISENWVLTAAHCVS----GASDVKVVLGahNIVLREGGEQKFDVEKIIV 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264363 520 HEGYTHDaGFDNDIALIKLNNKVVINSNITPICLPRKEAESFMRTddIGTASGWGLTQRGFLARNLMYVDIPIVDHQKCT 599
Cdd:pfam00089 77 HPNYNPD-TLDNDIALLKLESPVTLGDTVRPICLPDASSDLPVGT--TCTVSGWGNTKTLGPSDTLQEVTVPVVSRETCR 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264363 600 AAYekppypRGSVTANMLCAGleSGGKDSCRGDSGGALVFLDSEterwfVGGIVSWGSmNCGEAGQYGVYTKVINYIPWI 679
Cdd:pfam00089 154 SAY------GGTVTDTMICAG--AGGKDACQGDSGGPLVCSDGE-----LIGIVSWGY-GCASGNYPGVYTPVSSYLDWI 219
|
|
| COG5640 |
COG5640 |
Secreted trypsin-like serine protease [Posttranslational modification, protein turnover, ... |
432-683 |
3.40e-54 |
|
Secreted trypsin-like serine protease [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 444365 [Multi-domain] Cd Length: 262 Bit Score: 186.78 E-value: 3.40e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264363 432 PVCGLSARTTGGRIYGGQKAKPGDFPWQVLIL--GGTTAA---GALLYDNWVLTAAHAVYEQkhDASALDIRMGTLKRLS 506
Cdd:COG5640 18 ALAAAPAADAAPAIVGGTPATVGEYPWMVALQssNGPSGQfcgGTLIAPRWVLTAAHCVDGD--GPSDLRVVIGSTDLST 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264363 507 PHYTQAWSEAVFIHEGYThDAGFDNDIALIKLNNKVvinSNITPICLPrkEAESFMRTDDIGTASGWGLT--QRGFLARN 584
Cdd:COG5640 96 SGGTVVKVARIVVHPDYD-PATPGNDIALLKLATPV---PGVAPAPLA--TSADAAAPGTPATVAGWGRTseGPGSQSGT 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264363 585 LMYVDIPIVDHQKCTAayekppyPRGSVTANMLCAGLESGGKDSCRGDSGGALVFLDSetERWFVGGIVSWGSMNCGeAG 664
Cdd:COG5640 170 LRKADVPVVSDATCAA-------YGGFDGGTMLCAGYPEGGKDACQGDSGGPLVVKDG--GGWVLVGVVSWGGGPCA-AG 239
|
250
....*....|....*....
gi 21264363 665 QYGVYTKVINYIPWIENII 683
Cdd:COG5640 240 YPGVYTRVSAYRDWIKSTA 258
|
|
| CUB |
pfam00431 |
CUB domain; |
184-293 |
1.45e-31 |
|
CUB domain;
Pssm-ID: 395345 [Multi-domain] Cd Length: 110 Bit Score: 118.55 E-value: 1.45e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264363 184 CSGqVFTQRSGELSSPEYPRPYPKLSSCTYSISLEEGFSVILDFvESFDVETHPEtlCPYDFLKIQTDREE----HGPFC 259
Cdd:pfam00431 1 CGG-VLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTF-QDFELEDHDE--CGYDYVEIRDGPSAssplLGRFC 76
|
90 100 110
....*....|....*....|....*....|....
gi 21264363 260 GKTLPHRIETKSNTVTITFVTDESGDHTGWKIHY 293
Cdd:pfam00431 77 GSGIPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
|
|
| CUB |
cd00041 |
CUB domain; extracellular domain; present in proteins mostly known to be involved in ... |
184-295 |
2.55e-31 |
|
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
Pssm-ID: 238001 [Multi-domain] Cd Length: 113 Bit Score: 117.90 E-value: 2.55e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264363 184 CSGQVFTQRSGELSSPEYPRPYPKLSSCTYSISLEEGFSVILDFvESFDVETHPEtlCPYDFLKI----QTDREEHGPFC 259
Cdd:cd00041 1 CGGTLTASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTF-EDFDLESSPN--CSYDYLEIydgpSTSSPLLGRFC 77
|
90 100 110
....*....|....*....|....*....|....*.
gi 21264363 260 GKTLPHRIETKSNTVTITFVTDESGDHTGWKIHYTS 295
Cdd:cd00041 78 GSTLPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
|
|
| CUB |
smart00042 |
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ... |
194-293 |
1.38e-27 |
|
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.
Pssm-ID: 214483 [Multi-domain] Cd Length: 102 Bit Score: 107.09 E-value: 1.38e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264363 194 GELSSPEYPRPYPKLSSCTYSISLEEGFSVILDFvESFDVETHPEtlCPYDFLKIQ----TDREEHGPFCGKTLPHR-IE 268
Cdd:smart00042 1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQF-TDFDLESSDN--CEYDYVEIYdgpsASSPLLGRFCGSEAPPPvIS 77
|
90 100
....*....|....*....|....*
gi 21264363 269 TKSNTVTITFVTDESGDHTGWKIHY 293
Cdd:smart00042 78 SSSNSLTLTFVSDSSVQKRGFSARY 102
|
|
| CUB |
smart00042 |
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ... |
28-134 |
1.40e-27 |
|
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.
Pssm-ID: 214483 [Multi-domain] Cd Length: 102 Bit Score: 107.09 E-value: 1.40e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264363 28 GRLASPGFPGEYANDQERRWTLTAPPGYRLRLYFTHFDLELSHLCEYDFVKLSSG----AKVLATLCGQEstdteraPGK 103
Cdd:smart00042 1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYDGpsasSPLLGRFCGSE-------APP 73
|
90 100 110
....*....|....*....|....*....|.
gi 21264363 104 DTFYSLGSSLDITFRSDYSNEKpfTGFEAFY 134
Cdd:smart00042 74 PVISSSSNSLTLTFVSDSSVQK--RGFSARY 102
|
|
| CUB |
cd00041 |
CUB domain; extracellular domain; present in proteins mostly known to be involved in ... |
11-136 |
6.11e-27 |
|
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
Pssm-ID: 238001 [Multi-domain] Cd Length: 113 Bit Score: 105.57 E-value: 6.11e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264363 11 CGSVATplgpkwpEPVFGRLASPGFPGEYANDQERRWTLTAPPGYRLRLYFTHFDLELSHLCEYDFVKLSSG----AKVL 86
Cdd:cd00041 1 CGGTLT-------ASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGpstsSPLL 73
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 21264363 87 ATLCGQEStdterapgKDTFYSLGSSLDITFRSDYSNEKpfTGFEAFYAA 136
Cdd:cd00041 74 GRFCGSTL--------PPPIISSGNSLTVRFRSDSSVTG--RGFKATYSA 113
|
|
| CUB |
pfam00431 |
CUB domain; |
11-134 |
7.87e-17 |
|
CUB domain;
Pssm-ID: 395345 [Multi-domain] Cd Length: 110 Bit Score: 76.56 E-value: 7.87e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264363 11 CGSVATPLgpkwpepvFGRLASPGFPGEYANDQERRWTLTAPPGYRLRLYFTHFDLELSHLCEYDFVKLSSG----AKVL 86
Cdd:pfam00431 1 CGGVLTDS--------SGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGpsasSPLL 72
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 21264363 87 ATLCGQEstdterAPgkDTFYSLGSSLDITFRSDYSNEKpfTGFEAFY 134
Cdd:pfam00431 73 GRFCGSG------IP--EDIVSSSNQMTIKFVSDASVQK--RGFKATY 110
|
|
| CCP |
smart00032 |
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ... |
300-361 |
7.30e-10 |
|
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.
Pssm-ID: 214478 [Multi-domain] Cd Length: 56 Bit Score: 55.23 E-value: 7.30e-10
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 21264363 300 CPYPMAPPNGHVSPVQAKYILKDSFSIFCETGYELLQghlplkSFTAVCQKDGSWDRPMPAC 361
Cdd:smart00032 1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIG------SSTITCLENGTWSPPPPTC 56
|
|
| CCP |
cd00033 |
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ... |
300-361 |
1.98e-09 |
|
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.
Pssm-ID: 153056 [Multi-domain] Cd Length: 57 Bit Score: 54.01 E-value: 1.98e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 21264363 300 CPYPMAPPNGHVSPVQAKYILKDSFSIFCETGYELLQghlplkSFTAVCQKDGSWDRPMPAC 361
Cdd:cd00033 1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVG------SSTITCTENGGWSPPPPTC 56
|
|
| Sushi |
pfam00084 |
Sushi repeat (SCR repeat); |
300-361 |
3.74e-09 |
|
Sushi repeat (SCR repeat);
Pssm-ID: 459664 [Multi-domain] Cd Length: 56 Bit Score: 52.89 E-value: 3.74e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 21264363 300 CPYPMAPPNGHVSPVQAKYILKDSFSIFCETGYELlQGhlplkSFTAVCQKDGSWDRPMPAC 361
Cdd:pfam00084 1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYRL-VG-----SPTITCQEDGTWSPPFPEC 56
|
|
| Sushi |
pfam00084 |
Sushi repeat (SCR repeat); |
366-430 |
3.52e-07 |
|
Sushi repeat (SCR repeat);
Pssm-ID: 459664 [Multi-domain] Cd Length: 56 Bit Score: 47.49 E-value: 3.52e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 21264363 366 CGPPDDLPSGRVEYITGPgvTTYKAVIQYSCEETFYTMKVNdgKYVCEADGFWTSSKgekslPVC 430
Cdd:pfam00084 1 CPPPPDIPNGKVSATKNE--YNYGASVSYECDPGYRLVGSP--TITCQEDGTWSPPF-----PEC 56
|
|
| FXa_inhibition |
pfam14670 |
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ... |
152-180 |
2.90e-06 |
|
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.
Pssm-ID: 464251 [Multi-domain] Cd Length: 36 Bit Score: 44.16 E-value: 2.90e-06
10 20
....*....|....*....|....*....
gi 21264363 152 CDHHCHNHLGGFYCSCRAGYVLHRNKRTC 180
Cdd:pfam14670 8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
|
|
| EGF_CA |
smart00179 |
Calcium-binding EGF-like domain; |
138-176 |
3.36e-06 |
|
Calcium-binding EGF-like domain;
Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 44.16 E-value: 3.36e-06
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 21264363 138 DIDECQvapgEAPTCDHH--CHNHLGGFYCSCRAGYVLHRN 176
Cdd:smart00179 1 DIDECA----SGNPCQNGgtCVNTVGSYRCECPPGYTDGRN 37
|
|
| EGF_CA |
cd00054 |
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
138-175 |
9.83e-06 |
|
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.
Pssm-ID: 238011 Cd Length: 38 Bit Score: 42.62 E-value: 9.83e-06
10 20 30 40
....*....|....*....|....*....|....*....|
gi 21264363 138 DIDECQvapgEAPTCDHH--CHNHLGGFYCSCRAGYVLHR 175
Cdd:cd00054 1 DIDECA----SGNPCQNGgtCVNTVGSYRCSCPPGYTGRN 36
|
|
| PHA02817 |
PHA02817 |
EEV Host range protein; Provisional |
300-430 |
1.22e-04 |
|
EEV Host range protein; Provisional
Pssm-ID: 165167 [Multi-domain] Cd Length: 225 Bit Score: 44.16 E-value: 1.22e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264363 300 CPYPMAPPNGHVSPVQAKYILKDSFSIFCETGYELLQGHLpLKSFTAVCQKDGSWDRPMPACSIVDCGPPdDLPSGRVEY 379
Cdd:PHA02817 24 CCYPPSIKNGYIYNKKTEYNIGSNVTFFCGNNTRGVRYTL-VGEKNIICEKDGKWNKEFPVCKIIRCRFP-ALQNGFVNG 101
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 21264363 380 ITGPGVTTYKAVIQYSCEETFytMKVNDGKYVCEADGFWTSskgekSLPVC 430
Cdd:PHA02817 102 IPDSKKFYYESEVSFSCKPGF--VLIGTKYSVCGINSSWIP-----KVPIC 145
|
|
|
|
Name |
Accession |
Description |
Interval |
E-value |
| Tryp_SPc |
cd00190 |
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens ... |
445-682 |
1.13e-79 |
|
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad residues.
Pssm-ID: 238113 [Multi-domain] Cd Length: 232 Bit Score: 252.97 E-value: 1.13e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264363 445 IYGGQKAKPGDFPWQVLI---LGGTTAAGALLYDNWVLTAAHAVYEQkhDASALDIRMGTLKRLSPHYTQ--AWSEAVFI 519
Cdd:cd00190 1 IVGGSEAKIGSFPWQVSLqytGGRHFCGGSLISPRWVLTAAHCVYSS--APSNYTVRLGSHDLSSNEGGGqvIKVKKVIV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264363 520 HEGYtHDAGFDNDIALIKLNNKVVINSNITPICLPRKEAEsfMRTDDIGTASGWGLTQ-RGFLARNLMYVDIPIVDHQKC 598
Cdd:cd00190 79 HPNY-NPSTYDNDIALLKLKRPVTLSDNVRPICLPSSGYN--LPAGTTCTVSGWGRTSeGGPLPDVLQEVNVPIVSNAEC 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264363 599 TAAYEKPPYprgsVTANMLCAGLESGGKDSCRGDSGGALVFLDseTERWFVGGIVSWGSmNCGEAGQYGVYTKVINYIPW 678
Cdd:cd00190 156 KRAYSYGGT----ITDNMLCAGGLEGGKDACQGDSGGPLVCND--NGRGVLVGIVSWGS-GCARPNYPGVYTRVSSYLDW 228
|
....
gi 21264363 679 IENI 682
Cdd:cd00190 229 IQKT 232
|
|
| Tryp_SPc |
smart00020 |
Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens ... |
444-679 |
9.87e-79 |
|
Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. A few, however, are active as single chain molecules, and others are inactive due to substitutions of the catalytic triad residues.
Pssm-ID: 214473 Cd Length: 229 Bit Score: 250.67 E-value: 9.87e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264363 444 RIYGGQKAKPGDFPWQVLIL---GGTTAAGALLYDNWVLTAAHAVYeqKHDASALDIRMGTLKRLSPHYTQAWS-EAVFI 519
Cdd:smart00020 1 RIVGGSEANIGSFPWQVSLQyggGRHFCGGSLISPRWVLTAAHCVR--GSDPSNIRVRLGSHDLSSGEEGQVIKvSKVII 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264363 520 HEGYtHDAGFDNDIALIKLNNKVVINSNITPICLPRKEaeSFMRTDDIGTASGWGLTQ--RGFLARNLMYVDIPIVDHQK 597
Cdd:smart00020 79 HPNY-NPSTYDNDIALLKLKEPVTLSDNVRPICLPSSN--YNVPAGTTCTVSGWGRTSegAGSLPDTLQEVNVPIVSNAT 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264363 598 CTAAYekppYPRGSVTANMLCAGLESGGKDSCRGDSGGALVFLDsetERWFVGGIVSWGSmNCGEAGQYGVYTKVINYIP 677
Cdd:smart00020 156 CRRAY----SGGGAITDNMLCAGGLEGGKDACQGDSGGPLVCND---GRWVLVGIVSWGS-GCARPGKPGVYTRVSSYLD 227
|
..
gi 21264363 678 WI 679
Cdd:smart00020 228 WI 229
|
|
| Trypsin |
pfam00089 |
Trypsin; |
445-679 |
4.25e-55 |
|
Trypsin;
Pssm-ID: 459667 [Multi-domain] Cd Length: 219 Bit Score: 187.65 E-value: 4.25e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264363 445 IYGGQKAKPGDFPWQVLIL---GGTTAAGALLYDNWVLTAAHAVYeqkhDASALDIRMG--TLKRLSPHYTQAWSEAVFI 519
Cdd:pfam00089 1 IVGGDEAQPGSFPWQVSLQlssGKHFCGGSLISENWVLTAAHCVS----GASDVKVVLGahNIVLREGGEQKFDVEKIIV 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264363 520 HEGYTHDaGFDNDIALIKLNNKVVINSNITPICLPRKEAESFMRTddIGTASGWGLTQRGFLARNLMYVDIPIVDHQKCT 599
Cdd:pfam00089 77 HPNYNPD-TLDNDIALLKLESPVTLGDTVRPICLPDASSDLPVGT--TCTVSGWGNTKTLGPSDTLQEVTVPVVSRETCR 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264363 600 AAYekppypRGSVTANMLCAGleSGGKDSCRGDSGGALVFLDSEterwfVGGIVSWGSmNCGEAGQYGVYTKVINYIPWI 679
Cdd:pfam00089 154 SAY------GGTVTDTMICAG--AGGKDACQGDSGGPLVCSDGE-----LIGIVSWGY-GCASGNYPGVYTPVSSYLDWI 219
|
|
| COG5640 |
COG5640 |
Secreted trypsin-like serine protease [Posttranslational modification, protein turnover, ... |
432-683 |
3.40e-54 |
|
Secreted trypsin-like serine protease [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 444365 [Multi-domain] Cd Length: 262 Bit Score: 186.78 E-value: 3.40e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264363 432 PVCGLSARTTGGRIYGGQKAKPGDFPWQVLIL--GGTTAA---GALLYDNWVLTAAHAVYEQkhDASALDIRMGTLKRLS 506
Cdd:COG5640 18 ALAAAPAADAAPAIVGGTPATVGEYPWMVALQssNGPSGQfcgGTLIAPRWVLTAAHCVDGD--GPSDLRVVIGSTDLST 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264363 507 PHYTQAWSEAVFIHEGYThDAGFDNDIALIKLNNKVvinSNITPICLPrkEAESFMRTDDIGTASGWGLT--QRGFLARN 584
Cdd:COG5640 96 SGGTVVKVARIVVHPDYD-PATPGNDIALLKLATPV---PGVAPAPLA--TSADAAAPGTPATVAGWGRTseGPGSQSGT 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264363 585 LMYVDIPIVDHQKCTAayekppyPRGSVTANMLCAGLESGGKDSCRGDSGGALVFLDSetERWFVGGIVSWGSMNCGeAG 664
Cdd:COG5640 170 LRKADVPVVSDATCAA-------YGGFDGGTMLCAGYPEGGKDACQGDSGGPLVVKDG--GGWVLVGVVSWGGGPCA-AG 239
|
250
....*....|....*....
gi 21264363 665 QYGVYTKVINYIPWIENII 683
Cdd:COG5640 240 YPGVYTRVSAYRDWIKSTA 258
|
|
| CUB |
pfam00431 |
CUB domain; |
184-293 |
1.45e-31 |
|
CUB domain;
Pssm-ID: 395345 [Multi-domain] Cd Length: 110 Bit Score: 118.55 E-value: 1.45e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264363 184 CSGqVFTQRSGELSSPEYPRPYPKLSSCTYSISLEEGFSVILDFvESFDVETHPEtlCPYDFLKIQTDREE----HGPFC 259
Cdd:pfam00431 1 CGG-VLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTF-QDFELEDHDE--CGYDYVEIRDGPSAssplLGRFC 76
|
90 100 110
....*....|....*....|....*....|....
gi 21264363 260 GKTLPHRIETKSNTVTITFVTDESGDHTGWKIHY 293
Cdd:pfam00431 77 GSGIPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
|
|
| CUB |
cd00041 |
CUB domain; extracellular domain; present in proteins mostly known to be involved in ... |
184-295 |
2.55e-31 |
|
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
Pssm-ID: 238001 [Multi-domain] Cd Length: 113 Bit Score: 117.90 E-value: 2.55e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264363 184 CSGQVFTQRSGELSSPEYPRPYPKLSSCTYSISLEEGFSVILDFvESFDVETHPEtlCPYDFLKI----QTDREEHGPFC 259
Cdd:cd00041 1 CGGTLTASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTF-EDFDLESSPN--CSYDYLEIydgpSTSSPLLGRFC 77
|
90 100 110
....*....|....*....|....*....|....*.
gi 21264363 260 GKTLPHRIETKSNTVTITFVTDESGDHTGWKIHYTS 295
Cdd:cd00041 78 GSTLPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
|
|
| CUB |
smart00042 |
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ... |
194-293 |
1.38e-27 |
|
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.
Pssm-ID: 214483 [Multi-domain] Cd Length: 102 Bit Score: 107.09 E-value: 1.38e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264363 194 GELSSPEYPRPYPKLSSCTYSISLEEGFSVILDFvESFDVETHPEtlCPYDFLKIQ----TDREEHGPFCGKTLPHR-IE 268
Cdd:smart00042 1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQF-TDFDLESSDN--CEYDYVEIYdgpsASSPLLGRFCGSEAPPPvIS 77
|
90 100
....*....|....*....|....*
gi 21264363 269 TKSNTVTITFVTDESGDHTGWKIHY 293
Cdd:smart00042 78 SSSNSLTLTFVSDSSVQKRGFSARY 102
|
|
| CUB |
smart00042 |
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ... |
28-134 |
1.40e-27 |
|
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.
Pssm-ID: 214483 [Multi-domain] Cd Length: 102 Bit Score: 107.09 E-value: 1.40e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264363 28 GRLASPGFPGEYANDQERRWTLTAPPGYRLRLYFTHFDLELSHLCEYDFVKLSSG----AKVLATLCGQEstdteraPGK 103
Cdd:smart00042 1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYDGpsasSPLLGRFCGSE-------APP 73
|
90 100 110
....*....|....*....|....*....|.
gi 21264363 104 DTFYSLGSSLDITFRSDYSNEKpfTGFEAFY 134
Cdd:smart00042 74 PVISSSSNSLTLTFVSDSSVQK--RGFSARY 102
|
|
| CUB |
cd00041 |
CUB domain; extracellular domain; present in proteins mostly known to be involved in ... |
11-136 |
6.11e-27 |
|
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
Pssm-ID: 238001 [Multi-domain] Cd Length: 113 Bit Score: 105.57 E-value: 6.11e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264363 11 CGSVATplgpkwpEPVFGRLASPGFPGEYANDQERRWTLTAPPGYRLRLYFTHFDLELSHLCEYDFVKLSSG----AKVL 86
Cdd:cd00041 1 CGGTLT-------ASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGpstsSPLL 73
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 21264363 87 ATLCGQEStdterapgKDTFYSLGSSLDITFRSDYSNEKpfTGFEAFYAA 136
Cdd:cd00041 74 GRFCGSTL--------PPPIISSGNSLTVRFRSDSSVTG--RGFKATYSA 113
|
|
| CUB |
pfam00431 |
CUB domain; |
11-134 |
7.87e-17 |
|
CUB domain;
Pssm-ID: 395345 [Multi-domain] Cd Length: 110 Bit Score: 76.56 E-value: 7.87e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264363 11 CGSVATPLgpkwpepvFGRLASPGFPGEYANDQERRWTLTAPPGYRLRLYFTHFDLELSHLCEYDFVKLSSG----AKVL 86
Cdd:pfam00431 1 CGGVLTDS--------SGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGpsasSPLL 72
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 21264363 87 ATLCGQEstdterAPgkDTFYSLGSSLDITFRSDYSNEKpfTGFEAFY 134
Cdd:pfam00431 73 GRFCGSG------IP--EDIVSSSNQMTIKFVSDASVQK--RGFKATY 110
|
|
| CCP |
smart00032 |
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ... |
300-361 |
7.30e-10 |
|
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.
Pssm-ID: 214478 [Multi-domain] Cd Length: 56 Bit Score: 55.23 E-value: 7.30e-10
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 21264363 300 CPYPMAPPNGHVSPVQAKYILKDSFSIFCETGYELLQghlplkSFTAVCQKDGSWDRPMPAC 361
Cdd:smart00032 1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIG------SSTITCLENGTWSPPPPTC 56
|
|
| CCP |
cd00033 |
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ... |
300-361 |
1.98e-09 |
|
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.
Pssm-ID: 153056 [Multi-domain] Cd Length: 57 Bit Score: 54.01 E-value: 1.98e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 21264363 300 CPYPMAPPNGHVSPVQAKYILKDSFSIFCETGYELLQghlplkSFTAVCQKDGSWDRPMPAC 361
Cdd:cd00033 1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVG------SSTITCTENGGWSPPPPTC 56
|
|
| Sushi |
pfam00084 |
Sushi repeat (SCR repeat); |
300-361 |
3.74e-09 |
|
Sushi repeat (SCR repeat);
Pssm-ID: 459664 [Multi-domain] Cd Length: 56 Bit Score: 52.89 E-value: 3.74e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 21264363 300 CPYPMAPPNGHVSPVQAKYILKDSFSIFCETGYELlQGhlplkSFTAVCQKDGSWDRPMPAC 361
Cdd:pfam00084 1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYRL-VG-----SPTITCQEDGTWSPPFPEC 56
|
|
| eMpr |
COG3591 |
V8-like Glu-specific endopeptidase [Posttranslational modification, protein turnover, ... |
470-666 |
9.02e-08 |
|
V8-like Glu-specific endopeptidase [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 442810 [Multi-domain] Cd Length: 194 Bit Score: 52.76 E-value: 9.02e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264363 470 GALLYDNWVLTAAHAVYEQKHDASALDIRMGTLKRLSPhYTQAWSEAVFIHEGYTHDAGFDNDIALIKLNNKVvinSNIT 549
Cdd:COG3591 16 GTLIGPNLVLTAGHCVYDGAGGGWATNIVFVPGYNGGP-YGTATATRFRVPPGWVASGDAGYDYALLRLDEPL---GDTT 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264363 550 PiCLPRKEAESFMRTDDIgTASGWGLTQRGFLArnlMYVDIPIVDHQKCTAAYEkppyprgsvtanmlCaglesggkDSC 629
Cdd:COG3591 92 G-WLGLAFNDAPLAGEPV-TIIGYPGDRPKDLS---LDCSGRVTGVQGNRLSYD--------------C--------DTT 144
|
170 180 190
....*....|....*....|....*....|....*..
gi 21264363 630 RGDSGGALvfLDSETERWFVGGIVSWGSMNCGEAGQY 666
Cdd:COG3591 145 GGSSGSPV--LDDSDGGGRVVGVHSAGGADRANTGVR 179
|
|
| Sushi |
pfam00084 |
Sushi repeat (SCR repeat); |
366-430 |
3.52e-07 |
|
Sushi repeat (SCR repeat);
Pssm-ID: 459664 [Multi-domain] Cd Length: 56 Bit Score: 47.49 E-value: 3.52e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 21264363 366 CGPPDDLPSGRVEYITGPgvTTYKAVIQYSCEETFYTMKVNdgKYVCEADGFWTSSKgekslPVC 430
Cdd:pfam00084 1 CPPPPDIPNGKVSATKNE--YNYGASVSYECDPGYRLVGSP--TITCQEDGTWSPPF-----PEC 56
|
|
| FXa_inhibition |
pfam14670 |
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ... |
152-180 |
2.90e-06 |
|
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.
Pssm-ID: 464251 [Multi-domain] Cd Length: 36 Bit Score: 44.16 E-value: 2.90e-06
10 20
....*....|....*....|....*....
gi 21264363 152 CDHHCHNHLGGFYCSCRAGYVLHRNKRTC 180
Cdd:pfam14670 8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
|
|
| EGF_CA |
smart00179 |
Calcium-binding EGF-like domain; |
138-176 |
3.36e-06 |
|
Calcium-binding EGF-like domain;
Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 44.16 E-value: 3.36e-06
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 21264363 138 DIDECQvapgEAPTCDHH--CHNHLGGFYCSCRAGYVLHRN 176
Cdd:smart00179 1 DIDECA----SGNPCQNGgtCVNTVGSYRCECPPGYTDGRN 37
|
|
| EGF_CA |
cd00054 |
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
138-175 |
9.83e-06 |
|
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.
Pssm-ID: 238011 Cd Length: 38 Bit Score: 42.62 E-value: 9.83e-06
10 20 30 40
....*....|....*....|....*....|....*....|
gi 21264363 138 DIDECQvapgEAPTCDHH--CHNHLGGFYCSCRAGYVLHR 175
Cdd:cd00054 1 DIDECA----SGNPCQNGgtCVNTVGSYRCSCPPGYTGRN 36
|
|
| PHA02817 |
PHA02817 |
EEV Host range protein; Provisional |
300-430 |
1.22e-04 |
|
EEV Host range protein; Provisional
Pssm-ID: 165167 [Multi-domain] Cd Length: 225 Bit Score: 44.16 E-value: 1.22e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264363 300 CPYPMAPPNGHVSPVQAKYILKDSFSIFCETGYELLQGHLpLKSFTAVCQKDGSWDRPMPACSIVDCGPPdDLPSGRVEY 379
Cdd:PHA02817 24 CCYPPSIKNGYIYNKKTEYNIGSNVTFFCGNNTRGVRYTL-VGEKNIICEKDGKWNKEFPVCKIIRCRFP-ALQNGFVNG 101
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 21264363 380 ITGPGVTTYKAVIQYSCEETFytMKVNDGKYVCEADGFWTSskgekSLPVC 430
Cdd:PHA02817 102 IPDSKKFYYESEVSFSCKPGF--VLIGTKYSVCGINSSWIP-----KVPIC 145
|
|
| EGF_CA |
pfam07645 |
Calcium-binding EGF domain; |
138-170 |
1.13e-03 |
|
Calcium-binding EGF domain;
Pssm-ID: 429571 Cd Length: 32 Bit Score: 36.83 E-value: 1.13e-03
10 20 30
....*....|....*....|....*....|....*
gi 21264363 138 DIDECQvapGEAPTCDH--HCHNHLGGFYCSCRAG 170
Cdd:pfam07645 1 DVDECA---TGTHNCPAntVCVNTIGSFECRCPDG 32
|
|
| PHA02927 |
PHA02927 |
secreted complement-binding protein; Provisional |
287-433 |
9.84e-03 |
|
secreted complement-binding protein; Provisional
Pssm-ID: 222943 [Multi-domain] Cd Length: 263 Bit Score: 38.48 E-value: 9.84e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21264363 287 TGWKIHYTSTAQPCPYPMAPPNGHVSPVQAKYilKDSFSIFCETGYELLQGHlplKSFTAVcQKDGS--WDRPMPACSIV 364
Cdd:PHA02927 73 TGWTLFNQCIKRRCPSPRDIDNGQLDIGGVDF--GSSITYSCNSGYQLIGES---KSYCEL-GSTGSmvWNPEAPICESV 146
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 21264363 365 DCGPPDDLPSGRveYITGPGVTTYKAVIQYSCeETFYTMKVNDGkYVCEAdGFWTSSkgekslPVCEPV 433
Cdd:PHA02927 147 KCQSPPSISNGR--HNGYEDFYTDGSVVTYSC-NSGYSLIGNSG-VLCSG-GEWSDP------PTCQIV 204
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