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Conserved domains on  [gi|89353278|ref|NP_006634|]
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endosome-associated-trafficking regulator 1 isoform 2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SMC_prok_B super family cl37069
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 238-410 2.43e-05

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


The actual alignment was detected with superfamily member TIGR02168:

Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 46.59  E-value: 2.43e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89353278    238 DRHLRTLQISYDALKDENSKLRRKLNEVQSFSEAQTEMVRTLERKLEakMIKEEsdyhdlesvVQQVEQNLELMTKRAVK 317
Cdd:TIGR02168  259 TAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQ--ILRER---------LANLERQLEELEAQLEE 327

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89353278    318 AENHVVKLKQEISLLQAQVSNFQRENEALRcGQGASLTVVKQNADVALQNLRVVMNSAQASIKQLVSGAETLNlvAEILK 397
Cdd:TIGR02168  328 LESKLDELAEELAELEEKLEELKEELESLE-AELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLN--NEIER 404

                          170
                   ....*....|...
gi 89353278    398 SIDRISEVKDEEE 410
Cdd:TIGR02168  405 LEARLERLEDRRE 417
 
Name Accession Description Interval E-value
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 238-410 2.43e-05

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 46.59  E-value: 2.43e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89353278    238 DRHLRTLQISYDALKDENSKLRRKLNEVQSFSEAQTEMVRTLERKLEakMIKEEsdyhdlesvVQQVEQNLELMTKRAVK 317
Cdd:TIGR02168  259 TAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQ--ILRER---------LANLERQLEELEAQLEE 327

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89353278    318 AENHVVKLKQEISLLQAQVSNFQRENEALRcGQGASLTVVKQNADVALQNLRVVMNSAQASIKQLVSGAETLNlvAEILK 397
Cdd:TIGR02168  328 LESKLDELAEELAELEEKLEELKEELESLE-AELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLN--NEIER 404

                          170
                   ....*....|...
gi 89353278    398 SIDRISEVKDEEE 410
Cdd:TIGR02168  405 LEARLERLEDRRE 417
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
235-410 1.92e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 40.27  E-value: 1.92e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89353278 235 SLGDRHLRTLQISYDALKDENSKLRRKLNEvqsfseAQTEMvRTLERKLEAKmiKEEsdyhdlesvVQQVEQNLELMTKR 314
Cdd:COG4372  27 AALSEQLRKALFELDKLQEELEQLREELEQ------AREEL-EQLEEELEQA--RSE---------LEQLEEELEELNEQ 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89353278 315 AVKAENHVVKLKQEISLLQAQVSNFQRENEALRcGQGASLTVVKQNADVALQNLRVVMNSAQASIKQLVSGAETL-NLVA 393
Cdd:COG4372  89 LQAAQAELAQAQEELESLQEEAEELQEELEELQ-KERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLqEELA 167

                       170
                ....*....|....*..
gi 89353278 394 EILKSIDRISEVKDEEE 410
Cdd:COG4372 168 ALEQELQALSEAEAEQA 184
AAA_13 pfam13166
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA ...
 241-338 7.03e-03

AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins. This family includes the PrrC protein that is thought to be the active component of the anticodon nuclease.


Pssm-ID: 463796 [Multi-domain]  Cd Length: 712  Bit Score: 38.50  E-value: 7.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89353278   241 LRTLQISYDALKDE---NSKLRRKLNEVQSFSEAQTEMVRTLER-----------------KLEAKMIKE-ESDYHDLES 299
Cdd:pfam13166 337 LDGLRRALEAKRKDpfkSIELDSVDAKIESINDLVASINELIAKhneitdnfeeeknkakkKLRLHLVEEfKSEIDEYKD 416

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 89353278   300 VVQQVEQNLELMTKRAVKAENHVVKLKQEISLLQAQVSN 338
Cdd:pfam13166 417 KYAGLEKAINSLEKEIKNLEAEIKKLREEIKELEAQLRD 455
 
Name Accession Description Interval E-value
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 238-410 2.43e-05

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 46.59  E-value: 2.43e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89353278    238 DRHLRTLQISYDALKDENSKLRRKLNEVQSFSEAQTEMVRTLERKLEakMIKEEsdyhdlesvVQQVEQNLELMTKRAVK 317
Cdd:TIGR02168  259 TAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQ--ILRER---------LANLERQLEELEAQLEE 327

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89353278    318 AENHVVKLKQEISLLQAQVSNFQRENEALRcGQGASLTVVKQNADVALQNLRVVMNSAQASIKQLVSGAETLNlvAEILK 397
Cdd:TIGR02168  328 LESKLDELAEELAELEEKLEELKEELESLE-AELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLN--NEIER 404

                          170
                   ....*....|...
gi 89353278    398 SIDRISEVKDEEE 410
Cdd:TIGR02168  405 LEARLERLEDRRE 417
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 249-363 1.19e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 41.21  E-value: 1.19e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89353278    249 DALKDE----NSKLRRKLNEVQSFSEAQTEMVRTLERkLEAKMIKEESDYHDLESVVQQVEQNLELMTKRAVKAENHVVK 324
Cdd:TIGR02169  395 EKLKREinelKRELDRLQEELQRLSEELADLNAAIAG-IEAKINELEEEKEDKALEIKKQEWKLEQLAADLSKYEQELYD 473

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 89353278    325 LKQEISLLQAQVSNFQRENEALRCGQGASLTVVKQNADV 363
Cdd:TIGR02169  474 LKEEYDRVEKELSKLQRELAEAEAQARASEERVRGGRAV 512
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
235-410 1.92e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 40.27  E-value: 1.92e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89353278 235 SLGDRHLRTLQISYDALKDENSKLRRKLNEvqsfseAQTEMvRTLERKLEAKmiKEEsdyhdlesvVQQVEQNLELMTKR 314
Cdd:COG4372  27 AALSEQLRKALFELDKLQEELEQLREELEQ------AREEL-EQLEEELEQA--RSE---------LEQLEEELEELNEQ 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89353278 315 AVKAENHVVKLKQEISLLQAQVSNFQRENEALRcGQGASLTVVKQNADVALQNLRVVMNSAQASIKQLVSGAETL-NLVA 393
Cdd:COG4372  89 LQAAQAELAQAQEELESLQEEAEELQEELEELQ-KERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLqEELA 167

                       170
                ....*....|....*..
gi 89353278 394 EILKSIDRISEVKDEEE 410
Cdd:COG4372 168 ALEQELQALSEAEAEQA 184
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 267-399 3.42e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 39.36  E-value: 3.42e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89353278 267 SFSEAQTEMVRTLERKLEA--KMIKE-ESDYHDLESVVQQVEQNLELMTKRAVKAENHVVKLKQEISLLQAQVSNFQREN 343
Cdd:COG4942  13 LAAAAQADAAAEAEAELEQlqQEIAElEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEI 92

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 89353278 344 EALRcgqgASLTvvKQNADVALQNLRVVMNSAQASIKQLVSGAETLNLV--AEILKSI 399
Cdd:COG4942  93 AELR----AELE--AQKEELAELLRALYRLGRQPPLALLLSPEDFLDAVrrLQYLKYL 144
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 251-409 6.10e-03

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 38.85  E-value: 6.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89353278   251 LKDENSKLRRKLNEVQSFSEAQ-------TEMVRTLERKLEAKMIKEESDYH-DLESVVQQVEQNLELMTKRAVKAENHV 322
Cdd:TIGR04523 258 LKDEQNKIKKQLSEKQKELEQNnkkikelEKQLNQLKSEISDLNNQKEQDWNkELKSELKNQEKKLEEIQNQISQNNKII 337

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89353278   323 VKLKQEISLLQAQVSNFQRENEALRcgqgASLTvVKQNadvALQNLRVVMNSAQASIKQLVSGAETLNLVaeiLKSIDRI 402
Cdd:TIGR04523 338 SQLNEQISQLKKELTNSESENSEKQ----RELE-EKQN---EIEKLKKENQSYKQEIKNLESQINDLESK---IQNQEKL 406


                  ....*..
gi 89353278   403 SEVKDEE 409
Cdd:TIGR04523 407 NQQKDEQ 413
AAA_13 pfam13166
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA ...
 241-338 7.03e-03

AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins. This family includes the PrrC protein that is thought to be the active component of the anticodon nuclease.


Pssm-ID: 463796 [Multi-domain]  Cd Length: 712  Bit Score: 38.50  E-value: 7.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89353278   241 LRTLQISYDALKDE---NSKLRRKLNEVQSFSEAQTEMVRTLER-----------------KLEAKMIKE-ESDYHDLES 299
Cdd:pfam13166 337 LDGLRRALEAKRKDpfkSIELDSVDAKIESINDLVASINELIAKhneitdnfeeeknkakkKLRLHLVEEfKSEIDEYKD 416

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 89353278   300 VVQQVEQNLELMTKRAVKAENHVVKLKQEISLLQAQVSN 338
Cdd:pfam13166 417 KYAGLEKAINSLEKEIKNLEAEIKKLREEIKELEAQLRD 455
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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