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Conserved domains on  [gi|5730035|ref|NP_006655|]
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C-C motif chemokine 27 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Chemokine super family cl00134
Chemokine: small cytokines, including a number of secreted growth factors and interferons ...
 33-83 5.98e-03

Chemokine: small cytokines, including a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; distinguished from other cytokines by their receptors, which are G-protein coupled receptors; divided into 4 subfamilies based on the arrangement of the two N-terminal cysteines; some members can bind multiple receptors and many chemokine receptors can bind more than one chemokine; this redundancy allows precise control in stimulating the immune system and in contributing to the homeostasis of a cell; when expressed inappropriately, chemokines play a role in autoimmune diseases, vascular irregularities, graft rejection, neoplasia, and allergies; exist as monomers, dimers and multimers, but are believed to function as monomers; found only in vertebrates and a few viruses. See CDs: Chemokine_CXC (cd00273), Chemokine_CC (cd00272), Chemokine_C (cd00271), and Chemokine_CX3C (cd00274) for chemokine subgroups.


The actual alignment was detected with superfamily member cd00169:

Pssm-ID: 469625  Cd Length: 59  Bit Score: 32.69  E-value: 5.98e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 5730035   33 CCTQLYRKPLSDKLLRKVIQvelQEADGDCHLQAFVLHLAQ-RSICIHPQNP 83
Cdd:cd00169   1 CCLKYTSKPIPPKNIKSYRV---QEAGGHCSIPAVIFTTKKgRKVCADPKEP 49
 
Name Accession Description Interval E-value
Chemokine cd00169
Chemokine: small cytokines, including a number of secreted growth factors and interferons ...
 33-83 5.98e-03

Chemokine: small cytokines, including a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; distinguished from other cytokines by their receptors, which are G-protein coupled receptors; divided into 4 subfamilies based on the arrangement of the two N-terminal cysteines; some members can bind multiple receptors and many chemokine receptors can bind more than one chemokine; this redundancy allows precise control in stimulating the immune system and in contributing to the homeostasis of a cell; when expressed inappropriately, chemokines play a role in autoimmune diseases, vascular irregularities, graft rejection, neoplasia, and allergies; exist as monomers, dimers and multimers, but are believed to function as monomers; found only in vertebrates and a few viruses. See CDs: Chemokine_CXC (cd00273), Chemokine_CC (cd00272), Chemokine_C (cd00271), and Chemokine_CX3C (cd00274) for chemokine subgroups.


Pssm-ID: 238098  Cd Length: 59  Bit Score: 32.69  E-value: 5.98e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 5730035   33 CCTQLYRKPLSDKLLRKVIQvelQEADGDCHLQAFVLHLAQ-RSICIHPQNP 83
Cdd:cd00169   1 CCLKYTSKPIPPKNIKSYRV---QEAGGHCSIPAVIFTTKKgRKVCADPKEP 49
 
Name Accession Description Interval E-value
Chemokine cd00169
Chemokine: small cytokines, including a number of secreted growth factors and interferons ...
 33-83 5.98e-03

Chemokine: small cytokines, including a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; distinguished from other cytokines by their receptors, which are G-protein coupled receptors; divided into 4 subfamilies based on the arrangement of the two N-terminal cysteines; some members can bind multiple receptors and many chemokine receptors can bind more than one chemokine; this redundancy allows precise control in stimulating the immune system and in contributing to the homeostasis of a cell; when expressed inappropriately, chemokines play a role in autoimmune diseases, vascular irregularities, graft rejection, neoplasia, and allergies; exist as monomers, dimers and multimers, but are believed to function as monomers; found only in vertebrates and a few viruses. See CDs: Chemokine_CXC (cd00273), Chemokine_CC (cd00272), Chemokine_C (cd00271), and Chemokine_CX3C (cd00274) for chemokine subgroups.


Pssm-ID: 238098  Cd Length: 59  Bit Score: 32.69  E-value: 5.98e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 5730035   33 CCTQLYRKPLSDKLLRKVIQvelQEADGDCHLQAFVLHLAQ-RSICIHPQNP 83
Cdd:cd00169   1 CCLKYTSKPIPPKNIKSYRV---QEAGGHCSIPAVIFTTKKgRKVCADPKEP 49
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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