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Conserved domains on  [gi|15431288|ref|NP_009035|]
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large ribosomal subunit protein uL1 [Homo sapiens]

Protein Classification

uL1 family ribosomal protein( domain architecture ID 291)

uL1 family ribosomal protein similar to Homo sapiens 60S ribosomal protein L10a and Saccharomyces cerevisiae 50S ribosomal protein L1

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Ribosomal_L1 super family cl00322
Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of ...
2-217 2.26e-116

Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds its own mRNA. Like several other large ribosomal subunit proteins, L1 displays RNA chaperone activity. L1 is one of the largest ribosomal proteins. It is composed of two domains that cycle between open and closed conformations via a hinge motion. The RNA-binding site of L1 is highly conserved, with both mRNA and rRNA binding the same binding site.


The actual alignment was detected with superfamily member PTZ00029:

Pssm-ID: 469720  Cd Length: 216  Bit Score: 330.16  E-value: 2.26e-116
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15431288    2 SSKVSRDTLYEAVREVLHGNQRKRRKFLETVELQISLKNYDPQKDKRFSGTVRLKSTPRPKFSVCVLGDQQHCDEAKAVD 81
Cdd:PTZ00029   1 MSKLSSEALRKAIAEILEGSEEKKRKFVETVELQIGLKDYDTQKDKRFSGSVKLPNVPKPNLKVCVLGDAVHCDEAKKLG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15431288   82 IPHMDIEALKKLNKNKKLVKKLAKKYDAFLASESLIKQIPRILGPGLNKAGKFPSLLTHNENMVAKVDEVKSTIKFQMKK 161
Cdd:PTZ00029  81 LDFMDIEGLKKFNKNKKLVKKLAKKYDAFLASQSLLPQIPRLLGPGLNKAGKFPTLITHNDDIEDKINELKSSVKFQLKK 160
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 15431288  162 VLCLAVAVGHVKMTDDELVYNIHLAVNFLVSLLKKNWQNVRALYIKSTMGKPQRLY 217
Cdd:PTZ00029 161 VLCLGVAVGNVEMTEEQLRQNIVLSINFLVSLLKKNWQNIKTLHIKSTMGKPQRIY 216
 
Name Accession Description Interval E-value
PTZ00029 PTZ00029
60S ribosomal protein L10a; Provisional
2-217 2.26e-116

60S ribosomal protein L10a; Provisional


Pssm-ID: 185405  Cd Length: 216  Bit Score: 330.16  E-value: 2.26e-116
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15431288    2 SSKVSRDTLYEAVREVLHGNQRKRRKFLETVELQISLKNYDPQKDKRFSGTVRLKSTPRPKFSVCVLGDQQHCDEAKAVD 81
Cdd:PTZ00029   1 MSKLSSEALRKAIAEILEGSEEKKRKFVETVELQIGLKDYDTQKDKRFSGSVKLPNVPKPNLKVCVLGDAVHCDEAKKLG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15431288   82 IPHMDIEALKKLNKNKKLVKKLAKKYDAFLASESLIKQIPRILGPGLNKAGKFPSLLTHNENMVAKVDEVKSTIKFQMKK 161
Cdd:PTZ00029  81 LDFMDIEGLKKFNKNKKLVKKLAKKYDAFLASQSLLPQIPRLLGPGLNKAGKFPTLITHNDDIEDKINELKSSVKFQLKK 160
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 15431288  162 VLCLAVAVGHVKMTDDELVYNIHLAVNFLVSLLKKNWQNVRALYIKSTMGKPQRLY 217
Cdd:PTZ00029 161 VLCLGVAVGNVEMTEEQLRQNIVLSINFLVSLLKKNWQNIKTLHIKSTMGKPQRIY 216
Ribosomal_L1 cd00403
Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of ...
10-216 1.26e-63

Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds its own mRNA. Like several other large ribosomal subunit proteins, L1 displays RNA chaperone activity. L1 is one of the largest ribosomal proteins. It is composed of two domains that cycle between open and closed conformations via a hinge motion. The RNA-binding site of L1 is highly conserved, with both mRNA and rRNA binding the same binding site.


Pssm-ID: 238235  Cd Length: 208  Bit Score: 196.25  E-value: 1.26e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15431288  10 LYEAVREVLhGNQRKRRKFLETVELQISLKNYDPQKDKRFSGTVRLKSTPRPKFSVCVLGDQQHCDEAKAVDIPHMDIEa 89
Cdd:cd00403   1 LEEAIKALK-KTSVKKRKFDETVELQINLKKDDRKKDQRIRGTVILPHGLGKDVKVCVFAKDEQAKEAKAAGADVVGGE- 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15431288  90 LKKLNKNKKLVKKLAKKYDAFLASESLIKQIPRILGPGLNKAGKFPSLLTH--NENMVAKVDEVKSTIKFQMKKVLCLAV 167
Cdd:cd00403  79 DLKKKIKNGEAKKLAKDFDLFLADPRIMMLLPKLLGKVLGPRGKMPNPKTGtvTEDLAKAIEEAKSSVEFRLDKGGCIHV 158
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 15431288 168 AVGHVKMTDDELVYNIHLAVNFLVSLLK-KNWQNVRALYIKSTMGKPQRL 216
Cdd:cd00403 159 PVGKVSMSPEQLVENIEAVINALVKKLPsKKGQNIKSIYLKTTMGPSLPI 208
Ribosomal_L1 pfam00687
Ribosomal protein L1p/L10e family; This family includes prokaryotic L1 and eukaryotic L10.
26-212 3.43e-52

Ribosomal protein L1p/L10e family; This family includes prokaryotic L1 and eukaryotic L10.


Pssm-ID: 459905  Cd Length: 197  Bit Score: 166.92  E-value: 3.43e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15431288    26 RKFLETVELQISLKNYDPQK-DKRFSGTVRLKSTPRPKFSVCVLGDQQHCDEAKAVDIPHMDIEALKKLNKNKKLVKKLA 104
Cdd:pfam00687   7 AKFDESVELALNLTGVDPRKaDQRVRGTIVLPHGTGKTVRVCVFAKDPQAEEAKEAGADVVGGEDLKEKIKNFEAKRKLA 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15431288   105 KKYDAFLASESLIKQIPRILGPGLNKAGKFPSLL--THNENMVAKVDEVKS-TIKFQMKKVLCLAVAVGHVKMTDDELVY 181
Cdd:pfam00687  87 KDFDLFLADPDIMPLLGKLLGKILGPRGKMPNPKkgTVTKDVAKAVEEAKSgTVEFRVDKGGCIHVKVGKVSFTPEQLAE 166
                         170       180       190
                  ....*....|....*....|....*....|.
gi 15431288   182 NIHLAVNFLVSLLKKNWQNVRALYIKSTMGK 212
Cdd:pfam00687 167 NIEAVIDALVKKKPKGGQNIKSIYLKTTMGP 197
 
Name Accession Description Interval E-value
PTZ00029 PTZ00029
60S ribosomal protein L10a; Provisional
2-217 2.26e-116

60S ribosomal protein L10a; Provisional


Pssm-ID: 185405  Cd Length: 216  Bit Score: 330.16  E-value: 2.26e-116
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15431288    2 SSKVSRDTLYEAVREVLHGNQRKRRKFLETVELQISLKNYDPQKDKRFSGTVRLKSTPRPKFSVCVLGDQQHCDEAKAVD 81
Cdd:PTZ00029   1 MSKLSSEALRKAIAEILEGSEEKKRKFVETVELQIGLKDYDTQKDKRFSGSVKLPNVPKPNLKVCVLGDAVHCDEAKKLG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15431288   82 IPHMDIEALKKLNKNKKLVKKLAKKYDAFLASESLIKQIPRILGPGLNKAGKFPSLLTHNENMVAKVDEVKSTIKFQMKK 161
Cdd:PTZ00029  81 LDFMDIEGLKKFNKNKKLVKKLAKKYDAFLASQSLLPQIPRLLGPGLNKAGKFPTLITHNDDIEDKINELKSSVKFQLKK 160
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 15431288  162 VLCLAVAVGHVKMTDDELVYNIHLAVNFLVSLLKKNWQNVRALYIKSTMGKPQRLY 217
Cdd:PTZ00029 161 VLCLGVAVGNVEMTEEQLRQNIVLSINFLVSLLKKNWQNIKTLHIKSTMGKPQRIY 216
PTZ00225 PTZ00225
60S ribosomal protein L10a; Provisional
3-217 5.80e-75

60S ribosomal protein L10a; Provisional


Pssm-ID: 140252  Cd Length: 214  Bit Score: 225.31  E-value: 5.80e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15431288    3 SKVSRDTLYEAVREVLhgNQRKRRKFLETVELQISLKNYDPQKDKRFSGTVRLKSTPRPKFSVCVLGDQQHCDEAKAVDI 82
Cdd:PTZ00225   2 SKIPPQTLSEAIQAVL--KVDKERKFKESIDLQVNLKNYDPQKDKRFSGSLKLPNVCRPRMTVCLLCDLVHEDIAKKEGV 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15431288   83 PHMDIEALKKLNKNKKLVKKLAKKYDAFLASESLIKQIPRILGPGLNKAGKFPSLLTHNENMVAKVDEVKSTIKFQMKKV 162
Cdd:PTZ00225  80 PTMNQEELKKLNKNKKLVKKMCNQYDAFLCSESIIKTVPRLVGPHMHRMGKFPTVCSPSESLPDKVVELRSTVKFQLKKV 159
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 15431288  163 LCLAVAVGHVKMTDDELVYNIHLAVNFLVSLLKKNWQNVRALYIKSTMGKPQRLY 217
Cdd:PTZ00225 160 LCLGTCVGHVEMTEEQLRQNVVMAINFLVSLLKKNWQNLKSAYIKSTMGKPQRIY 214
Ribosomal_L1 cd00403
Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of ...
10-216 1.26e-63

Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds its own mRNA. Like several other large ribosomal subunit proteins, L1 displays RNA chaperone activity. L1 is one of the largest ribosomal proteins. It is composed of two domains that cycle between open and closed conformations via a hinge motion. The RNA-binding site of L1 is highly conserved, with both mRNA and rRNA binding the same binding site.


Pssm-ID: 238235  Cd Length: 208  Bit Score: 196.25  E-value: 1.26e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15431288  10 LYEAVREVLhGNQRKRRKFLETVELQISLKNYDPQKDKRFSGTVRLKSTPRPKFSVCVLGDQQHCDEAKAVDIPHMDIEa 89
Cdd:cd00403   1 LEEAIKALK-KTSVKKRKFDETVELQINLKKDDRKKDQRIRGTVILPHGLGKDVKVCVFAKDEQAKEAKAAGADVVGGE- 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15431288  90 LKKLNKNKKLVKKLAKKYDAFLASESLIKQIPRILGPGLNKAGKFPSLLTH--NENMVAKVDEVKSTIKFQMKKVLCLAV 167
Cdd:cd00403  79 DLKKKIKNGEAKKLAKDFDLFLADPRIMMLLPKLLGKVLGPRGKMPNPKTGtvTEDLAKAIEEAKSSVEFRLDKGGCIHV 158
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 15431288 168 AVGHVKMTDDELVYNIHLAVNFLVSLLK-KNWQNVRALYIKSTMGKPQRL 216
Cdd:cd00403 159 PVGKVSMSPEQLVENIEAVINALVKKLPsKKGQNIKSIYLKTTMGPSLPI 208
Ribosomal_L1 pfam00687
Ribosomal protein L1p/L10e family; This family includes prokaryotic L1 and eukaryotic L10.
26-212 3.43e-52

Ribosomal protein L1p/L10e family; This family includes prokaryotic L1 and eukaryotic L10.


Pssm-ID: 459905  Cd Length: 197  Bit Score: 166.92  E-value: 3.43e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15431288    26 RKFLETVELQISLKNYDPQK-DKRFSGTVRLKSTPRPKFSVCVLGDQQHCDEAKAVDIPHMDIEALKKLNKNKKLVKKLA 104
Cdd:pfam00687   7 AKFDESVELALNLTGVDPRKaDQRVRGTIVLPHGTGKTVRVCVFAKDPQAEEAKEAGADVVGGEDLKEKIKNFEAKRKLA 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15431288   105 KKYDAFLASESLIKQIPRILGPGLNKAGKFPSLL--THNENMVAKVDEVKS-TIKFQMKKVLCLAVAVGHVKMTDDELVY 181
Cdd:pfam00687  87 KDFDLFLADPDIMPLLGKLLGKILGPRGKMPNPKkgTVTKDVAKAVEEAKSgTVEFRVDKGGCIHVKVGKVSFTPEQLAE 166
                         170       180       190
                  ....*....|....*....|....*....|.
gi 15431288   182 NIHLAVNFLVSLLKKNWQNVRALYIKSTMGK 212
Cdd:pfam00687 167 NIEAVIDALVKKKPKGGQNIKSIYLKTTMGP 197
rpl1P PRK04203
50S ribosomal protein L1P; Reviewed
5-215 7.45e-27

50S ribosomal protein L1P; Reviewed


Pssm-ID: 235254  Cd Length: 215  Bit Score: 102.24  E-value: 7.45e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15431288    5 VSRDTLYEAVREVLhgNQRKRRKFLETVELQISLKNYDPQK-DKRFSGTVRLKSTPRPKFSVCVLGDQQHCDEAKAVD-- 81
Cdd:PRK04203   2 MDREKIEEAVKEAL--EEAPKRNFTQSVDLIVNLKDIDLKKpENRIDEEVVLPHGRGKEVKIAVIAKGELALQAKEAGad 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15431288   82 --IPHMDIEALKKLNKNKKLVKKLakkYDAFLASESLIKQIPRILGPGLNKAGKFPSLLTHNENMVAKVDEVKSTIKFQM 159
Cdd:PRK04203  80 yvITREELEELGGDKRAAKKLANE---YDFFIAEADLMPLIGRYLGPVLGPRGKMPTPLPPNADIKPLVERLKNTVRIRT 156
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 15431288  160 KKVLCLAVAVGHVKMTDDELVYNIHLAVNFLVSLLKKNWQNVRALYIKSTMGKPQR 215
Cdd:PRK04203 157 KDQPTFHVRVGTEDMSPEELAENIDAVLNRIESKLEKGRQNIKSVYVKTTMGPAVK 212
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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