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Conserved domains on  [gi|1796787041|ref|NP_009054|]
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usherin isoform A precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LamGL smart00560
LamG-like jellyroll fold domain;
146-283 1.02e-36

LamG-like jellyroll fold domain;


:

Pssm-ID: 214722 [Multi-domain]  Cd Length: 133  Bit Score: 135.24  E-value: 1.02e-36
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796787041   146 ASFTLAVWLKPEQQGVMCVIEKtvdGQIVFKLTISEKETMFYYRTV--NGLQPPIKVMTLGRIlvKKWIHLSVQVHQ--T 221
Cdd:smart00560    1 GSFTLEAWVKLESAGGSQPIIT---GAAVAQPTISEKALTFFLRAKsvQGWQTARTGATADWI--GVWVHLAGVYDGgaG 75

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1796787041   222 KISFFINGVEKDHTPFnarTLSGSITDFASGTvQIGQSLNGLEQFVGRMQDFRLYQVALTNR 283
Cdd:smart00560   76 KLSLYVNGVEVATSET---QPSPSSGNLPQGG-RILLGGAGGENFSGRLDEVRVYNRALTAR 133
Laminin_N super family cl02806
Laminin N-terminal (Domain VI);
291-516 5.63e-29

Laminin N-terminal (Domain VI);


The actual alignment was detected with superfamily member pfam00055:

Pssm-ID: 470680  Cd Length: 230  Bit Score: 116.53  E-value: 5.63e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796787041  291 GDLL---RLHAQSHCrcpGSHPRvhplaQRYCIPNDAG-----DTADNRVSRLnpeAHPLSFV---NDNDVGTSWVSNvf 359
Cdd:pfam00055    6 GNLAfgrEVSATSTC---GLNGP-----ERYCILSGLEggkkcFICDSRDPHN---SHPPSNLtdsNNGTNETWWQSE-- 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796787041  360 TNITQLNQgVTISVDLEnGQYQVFYIIIQFFSPQPTEIRIQRKKENSLDWEDWQYFARNC-GAFGMKNNGDLE-KPDSVN 437
Cdd:pfam00055   73 TGVIQYEN-VNLTLDLG-KEFHFTYLILKFKSPRPAAMVLERSTDFGKTWQPYQYFASDCrRTFGRPSGPSRGiKDDEVI 150

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796787041  438 CLQL-SNFTPYSRGNVTFSILtpgpNYRPGYNNFYNTPSLQEFVKATQIRFHFH-----GQYYTTETAVNLRHrYYAVDE 511
Cdd:pfam00055  151 CTSEySDISPLTGGEVIFSTL----EGRPSANIFDYSPELQDWLTATNIRIRLLrlhtlGDELLDDPSVLRKY-YYAISD 225


                   ....*
gi 1796787041  512 ITISG 516
Cdd:pfam00055  226 ISVGG 230
FN3 super family cl27307
Fibronectin type 3 domain [General function prediction only];
1103-1469 5.46e-14

Fibronectin type 3 domain [General function prediction only];


The actual alignment was detected with superfamily member COG3401:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 76.96  E-value: 5.46e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796787041 1103 YPYSIQYFLDTDLLPYTKYSYYIETTNVHGSTrsvAVTYKTKPGVPEGNLTLSYIIPIGSDSVTLTWTTLSNQSGPIEKY 1182
Cdd:COG3401     93 GLTTLTGSGSVGGATNTGLTSSDEVPSPAVGT---ATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVV 169

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796787041 1183 IlscAPLAGGQPCVSYEGHETSATIW-----NLVPFAKYDFSVQACTSGGC-LHSLPITVTTAQAPPQRLSPPKMQKISS 1256
Cdd:COG3401    170 V---SPDTSATAAVATTSLTVTSTTLvdgggDIEPGTTYYYRVAATDTGGEsAPSNEVSVTTPTTPPSAPTGLTATADTP 246

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796787041 1257 TELHVEWSPPAELNgiIIRYELYmrrlRSTKettseesrvfqssgwlSPHSFVESANENAlkppqTMTTITGLEPYTKYE 1336
Cdd:COG3401    247 GSVTLSWDPVTESD--ATGYRVY----RSNS----------------GDGPFTKVATVTT-----TSYTDTGLTNGTTYY 299

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796787041 1337 FRVLAVNMAGSVS--SAWVSERTGESAPvfmIPPSVF---PLSSYSLNISWEKPADNvtrgKVVGYDInmlsEQSPQQSI 1411
Cdd:COG3401    300 YRVTAVDAAGNESapSNVVSVTTDLTPP---AAPSGLtatAVGSSSITLSWTASSDA----DVTGYNV----YRSTSGGG 368

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1796787041 1412 PmaFSQLLHTAKsqELSYTVEGLKPYRIYEFTITLCNSVGCVTSASGAGQTLAAAPAQ 1469
Cdd:COG3401    369 T--YTKIAETVT--TTSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEVSATTASAAS 422
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 900-948 8.99e-12

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


:

Pssm-ID: 238012  Cd Length: 50  Bit Score: 61.22  E-value: 8.99e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1796787041  900 CECDSLGTLPGTiCDPISGQCLCVPNRQGRRCNQCQPGFYISPGNATGC 948
Cdd:cd00055      2 CDCNGHGSLSGQ-CDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQGGGC 49
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 641-691 2.84e-11

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


:

Pssm-ID: 395007  Cd Length: 49  Bit Score: 59.67  E-value: 2.84e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1796787041  641 CDCDTVGTRNGSilCDQIGGQCNCKRHVSGRQCNQCQNGFYNLQELDPDGC 691
Cdd:pfam00053    1 CDCNPHGSLSDT--CDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 950-1000 4.88e-11

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


:

Pssm-ID: 238012  Cd Length: 50  Bit Score: 59.29  E-value: 4.88e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1796787041  950 PCSCHTTGAVNHICNSLTGQCVCQDAsIAGQRCDQCKDHYFGFDPQTGRCQ 1000
Cdd:cd00055      1 PCDCNGHGSLSGQCDPGTGQCECKPN-TTGRRCDRCAPGYYGLPSQGGGCQ 50
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 747-795 5.51e-11

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


:

Pssm-ID: 395007  Cd Length: 49  Bit Score: 58.90  E-value: 5.51e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1796787041  747 CQCNLHGSVNKFCNPHSGQCECKKEAKGLQCDTCRENFYGLDVTNCKAC 795
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 794-836 7.69e-10

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


:

Pssm-ID: 238012  Cd Length: 50  Bit Score: 55.82  E-value: 7.69e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1796787041  794 ACDCDTAGSLPGTvCNAKTGQCICKPNVEGRQCNKCLEGNFYL 836
Cdd:cd00055      1 PCDCNGHGSLSGQ-CDPGTGQCECKPNTTGRRCDRCAPGYYGL 42
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
847-897 1.44e-09

Laminin-type epidermal growth factor-like domai;


:

Pssm-ID: 214543  Cd Length: 46  Bit Score: 55.01  E-value: 1.44e-09
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|.
gi 1796787041   847 CNCDKTGTINGSllCNKSTGQCPCKLGVTGLRCNQCEPHRYNltiDNFQHC 897
Cdd:smart00180    1 CDCDPGGSASGT--CDPDTGQCECKPNVTGRRCDRCAPGYYG---DGPPGC 46
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1001-1037 9.70e-09

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


:

Pssm-ID: 238012  Cd Length: 50  Bit Score: 52.74  E-value: 9.70e-09
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1796787041 1001 PCNCHLSGALNETCHLVTGQCFCKQFVTGSKCDACVP 1037
Cdd:cd00055      1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAP 37
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
694-733 1.57e-08

Laminin-type epidermal growth factor-like domai;


:

Pssm-ID: 214543  Cd Length: 46  Bit Score: 51.93  E-value: 1.57e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 1796787041   694 CNCNTSGTVDGdiTCHQNSGQCKCKANVIGLRCDHCNFGF 733
Cdd:smart00180    1 CDCDPGGSASG--TCDPDTGQCECKPNVTGRRCDRCAPGY 38
fn3 pfam00041
Fibronectin type III domain;
1058-1132 1.91e-06

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 47.41  E-value: 1.91e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796787041 1058 PPPRG---QVQSSSAINLSWSPPDSPNAHWLTYSLlrdgfeIYTTEDQYPYSIQYFLD--------TDLLPYTKYSYYIE 1126
Cdd:pfam00041    1 SAPSNltvTDVTSTSLTVSWTPPPDGNGPITGYEV------EYRPKNSGEPWNEITVPgtttsvtlTGLKPGTEYEVRVQ 74


                   ....*.
gi 1796787041 1127 TTNVHG 1132
Cdd:pfam00041   75 AVNGGG 80
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 574-639 4.16e-04

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


:

Pssm-ID: 238012  Cd Length: 50  Bit Score: 39.64  E-value: 4.16e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1796787041  574 PCQCNSH---SKSCHYnisvdpfpfehfrgGGGVCDdCEHNTTGRNCELCKDYFFRqvgaDPSAIDVCK 639
Cdd:cd00055      1 PCDCNGHgslSGQCDP--------------GTGQCE-CKPNTTGRRCDRCAPGYYG----LPSQGGGCQ 50
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 517-565 3.78e-03

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


:

Pssm-ID: 238012  Cd Length: 50  Bit Score: 36.95  E-value: 3.78e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1796787041  517 RCQCHGHAD---NCDTTSqpYRCLCsqESFTEGLHCDRCLPLYNDKPFRQGD 565
Cdd:cd00055      1 PCDCNGHGSlsgQCDPGT--GQCEC--KPNTTGRRCDRCAPGYYGLPSQGGG 48
 
Name Accession Description Interval E-value
LamGL smart00560
LamG-like jellyroll fold domain;
146-283 1.02e-36

LamG-like jellyroll fold domain;


Pssm-ID: 214722 [Multi-domain]  Cd Length: 133  Bit Score: 135.24  E-value: 1.02e-36
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796787041   146 ASFTLAVWLKPEQQGVMCVIEKtvdGQIVFKLTISEKETMFYYRTV--NGLQPPIKVMTLGRIlvKKWIHLSVQVHQ--T 221
Cdd:smart00560    1 GSFTLEAWVKLESAGGSQPIIT---GAAVAQPTISEKALTFFLRAKsvQGWQTARTGATADWI--GVWVHLAGVYDGgaG 75

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1796787041   222 KISFFINGVEKDHTPFnarTLSGSITDFASGTvQIGQSLNGLEQFVGRMQDFRLYQVALTNR 283
Cdd:smart00560   76 KLSLYVNGVEVATSET---QPSPSSGNLPQGG-RILLGGAGGENFSGRLDEVRVYNRALTAR 133
Laminin_N pfam00055
Laminin N-terminal (Domain VI);
291-516 5.63e-29

Laminin N-terminal (Domain VI);


Pssm-ID: 459653  Cd Length: 230  Bit Score: 116.53  E-value: 5.63e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796787041  291 GDLL---RLHAQSHCrcpGSHPRvhplaQRYCIPNDAG-----DTADNRVSRLnpeAHPLSFV---NDNDVGTSWVSNvf 359
Cdd:pfam00055    6 GNLAfgrEVSATSTC---GLNGP-----ERYCILSGLEggkkcFICDSRDPHN---SHPPSNLtdsNNGTNETWWQSE-- 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796787041  360 TNITQLNQgVTISVDLEnGQYQVFYIIIQFFSPQPTEIRIQRKKENSLDWEDWQYFARNC-GAFGMKNNGDLE-KPDSVN 437
Cdd:pfam00055   73 TGVIQYEN-VNLTLDLG-KEFHFTYLILKFKSPRPAAMVLERSTDFGKTWQPYQYFASDCrRTFGRPSGPSRGiKDDEVI 150

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796787041  438 CLQL-SNFTPYSRGNVTFSILtpgpNYRPGYNNFYNTPSLQEFVKATQIRFHFH-----GQYYTTETAVNLRHrYYAVDE 511
Cdd:pfam00055  151 CTSEySDISPLTGGEVIFSTL----EGRPSANIFDYSPELQDWLTATNIRIRLLrlhtlGDELLDDPSVLRKY-YYAISD 225


                   ....*
gi 1796787041  512 ITISG 516
Cdd:pfam00055  226 ISVGG 230
LamNT smart00136
Laminin N-terminal domain (domain VI); N-terminal domain of laminins and laminin-related ...
 313-516 1.36e-21

Laminin N-terminal domain (domain VI); N-terminal domain of laminins and laminin-related protein such as Unc-6/ netrins.


Pssm-ID: 214532  Cd Length: 238  Bit Score: 95.50  E-value: 1.36e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796787041   313 PLAQRYCIPNDAG------DTADNRVSRLNpeaHPLSFV---NDNDVGTSWVSnvfTNITQLNQGVTISVDLENgQYQVF 383
Cdd:smart00136   29 PGPERYCKLVGHTeqgkkcDYCDARNPRRS---HPAENLtdgNNPNNPTWWQS---EPLSNGPQNVNLTLDLGK-EFHVT 101

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796787041   384 YIIIQFFSPQPTEIRIQRKKENSlDWEDWQYFARNCGA-FGMKNNGDLEKP--DSVNCL-QLSNFTPYSRGNVTFSILTP 459
Cdd:smart00136  102 YVILKFCSPRPSLWILERSDFGK-TWQPWQYFSSDCRRtFGRPPRGPITKGneDEVICTsEYSDIVPLEGGEIAFSLLEG 180

                           170       180       190       200       210       220
                    ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1796787041   460 gpnyRPGYNNFYNTPSLQEFVKATQIRFHFH-----GQYYTTETAVNLRHRYYAVDEITISG 516
Cdd:smart00136  181 ----RPSATDFDNSPVLQEWVTATNIRVRLTrlrtlGDELMDDRPEVTRRYYYAISDIAVGG 238
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1103-1469 5.46e-14

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 76.96  E-value: 5.46e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796787041 1103 YPYSIQYFLDTDLLPYTKYSYYIETTNVHGSTrsvAVTYKTKPGVPEGNLTLSYIIPIGSDSVTLTWTTLSNQSGPIEKY 1182
Cdd:COG3401     93 GLTTLTGSGSVGGATNTGLTSSDEVPSPAVGT---ATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVV 169

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796787041 1183 IlscAPLAGGQPCVSYEGHETSATIW-----NLVPFAKYDFSVQACTSGGC-LHSLPITVTTAQAPPQRLSPPKMQKISS 1256
Cdd:COG3401    170 V---SPDTSATAAVATTSLTVTSTTLvdgggDIEPGTTYYYRVAATDTGGEsAPSNEVSVTTPTTPPSAPTGLTATADTP 246

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796787041 1257 TELHVEWSPPAELNgiIIRYELYmrrlRSTKettseesrvfqssgwlSPHSFVESANENAlkppqTMTTITGLEPYTKYE 1336
Cdd:COG3401    247 GSVTLSWDPVTESD--ATGYRVY----RSNS----------------GDGPFTKVATVTT-----TSYTDTGLTNGTTYY 299

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796787041 1337 FRVLAVNMAGSVS--SAWVSERTGESAPvfmIPPSVF---PLSSYSLNISWEKPADNvtrgKVVGYDInmlsEQSPQQSI 1411
Cdd:COG3401    300 YRVTAVDAAGNESapSNVVSVTTDLTPP---AAPSGLtatAVGSSSITLSWTASSDA----DVTGYNV----YRSTSGGG 368

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1796787041 1412 PmaFSQLLHTAKsqELSYTVEGLKPYRIYEFTITLCNSVGCVTSASGAGQTLAAAPAQ 1469
Cdd:COG3401    369 T--YTKIAETVT--TTSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEVSATTASAAS 422
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1242-1357 5.63e-14

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 69.06  E-value: 5.63e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796787041 1242 PPQRLsppKMQKISSTELHVEWSPPAELNGIIIRYELYMRRLRSTKETTSEESRvfqssgwlsphsfvesanenalkPPQ 1321
Cdd:cd00063      3 PPTNL---RVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTP-----------------------GSE 56

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1796787041 1322 TMTTITGLEPYTKYEFRVLAVNMAG-SVSSAWVSERT 1357
Cdd:cd00063     57 TSYTLTGLKPGTEYEFRVRAVNGGGeSPPSESVTVTT 93
Laminin_G_3 pfam13385
Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin ...
 146-285 8.24e-14

Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin A-like lectin/glucanases superfamily.


Pssm-ID: 463865 [Multi-domain]  Cd Length: 151  Bit Score: 70.49  E-value: 8.24e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796787041  146 ASFTLAVWLKPEQ--QGVMCVIEKTVDGQIVFKLTiSEKETMFYYRTVNGLqpPIKVMTLGRILVKKWIHLSVQVHQTKI 223
Cdd:pfam13385   17 SDFTVSAWVKPDSlpGWARAIISSSGGGGYSLGLD-GDGRLRFAVNGGNGG--WDTVTSGASVPLGQWTHVAVTYDGGTL 93

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1796787041  224 SFFINGVEKDhtpfnARTLSGSITDFASGTVQIGQSLNGLEQFVGRMQDFRLYQVALTNREI 285
Cdd:pfam13385   94 RLYVNGVLVG-----SSTLTGGPPPGTGGPLYIGRSPGGDDYFNGLIDEVRIYDRALSAAEI 150
fn3 pfam00041
Fibronectin type III domain;
1150-1227 3.87e-13

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 66.28  E-value: 3.87e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796787041 1150 GNLTlsyIIPIGSDSVTLTWTTLSNQSGPIEKYILSCAPLAGGQPCVSYE--GHETSATIWNLVPFAKYDFSVQACTSGG 1227
Cdd:pfam00041    4 SNLT---VTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEITvpGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 900-948 8.99e-12

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 61.22  E-value: 8.99e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1796787041  900 CECDSLGTLPGTiCDPISGQCLCVPNRQGRRCNQCQPGFYISPGNATGC 948
Cdd:cd00055      2 CDCNGHGSLSGQ-CDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQGGGC 49
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 900-948 2.50e-11

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 60.06  E-value: 2.50e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1796787041  900 CECDSLGTLPGTiCDPISGQCLCVPNRQGRRCNQCQPGFY-ISPGNATGC 948
Cdd:pfam00053    1 CDCNPHGSLSDT-CDPETGQCLCKPGVTGRHCDRCKPGYYgLPSDPPQGC 49
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 641-691 2.84e-11

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 59.67  E-value: 2.84e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1796787041  641 CDCDTVGTRNGSilCDQIGGQCNCKRHVSGRQCNQCQNGFYNLQELDPDGC 691
Cdd:pfam00053    1 CDCNPHGSLSDT--CDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
900-944 2.94e-11

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 59.63  E-value: 2.94e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 1796787041   900 CECDSLGTLPGTiCDPISGQCLCVPNRQGRRCNQCQPGFYISPGN 944
Cdd:smart00180    1 CDCDPGGSASGT-CDPDTGQCECKPNVTGRRCDRCAPGYYGDGPP 44
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 950-1000 4.88e-11

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 59.29  E-value: 4.88e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1796787041  950 PCSCHTTGAVNHICNSLTGQCVCQDAsIAGQRCDQCKDHYFGFDPQTGRCQ 1000
Cdd:cd00055      1 PCDCNGHGSLSGQCDPGTGQCECKPN-TTGRRCDRCAPGYYGLPSQGGGCQ 50
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 747-795 5.51e-11

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 58.90  E-value: 5.51e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1796787041  747 CQCNLHGSVNKFCNPHSGQCECKKEAKGLQCDTCRENFYGLDVTNCKAC 795
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 640-691 6.29e-11

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 58.90  E-value: 6.29e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1796787041  640 PCDCDTVGTRNGSilCDQIGGQCNCKRHVSGRQCNQCQNGFYNLQElDPDGC 691
Cdd:cd00055      1 PCDCNGHGSLSGQ--CDPGTGQCECKPNTTGRRCDRCAPGYYGLPS-QGGGC 49
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1242-1347 9.05e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 59.55  E-value: 9.05e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796787041  1242 PPQRLsppKMQKISSTELHVEWSPPAELNGI--IIRYELYMRRLRSTKETTSEesrvfqssgwlsphsfvesanenalKP 1319
Cdd:smart00060    3 PPSNL---RVTDVTSTSVTLSWEPPPDDGITgyIVGYRVEYREEGSEWKEVNV-------------------------TP 54

                            90       100
                    ....*....|....*....|....*...
gi 1796787041  1320 PQTMTTITGLEPYTKYEFRVLAVNMAGS 1347
Cdd:smart00060   55 SSTSYTLTGLKPGTEYEFRVRAVNGAGE 82
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 746-788 9.12e-11

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 58.52  E-value: 9.12e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1796787041  746 PCQCNLHGSVNKFCNPHSGQCECKKEAKGLQCDTCRENFYGLD 788
Cdd:cd00055      1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLP 43
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
641-691 2.03e-10

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 57.32  E-value: 2.03e-10
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|.
gi 1796787041   641 CDCDTVGTRNGSilCDQIGGQCNCKRHVSGRQCNQCQNGFYNlqeLDPDGC 691
Cdd:smart00180    1 CDCDPGGSASGT--CDPDTGQCECKPNVTGRRCDRCAPGYYG---DGPPGC 46
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
747-792 5.46e-10

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 56.17  E-value: 5.46e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 1796787041   747 CQCNLHGSVNKFCNPHSGQCECKKEAKGLQCDTCRENFYGLDVTNC 792
Cdd:smart00180    1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDGPPGC 46
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 794-836 7.69e-10

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 55.82  E-value: 7.69e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1796787041  794 ACDCDTAGSLPGTvCNAKTGQCICKPNVEGRQCNKCLEGNFYL 836
Cdd:cd00055      1 PCDCNGHGSLSGQ-CDPGTGQCECKPNTTGRRCDRCAPGYYGL 42
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
795-834 9.54e-10

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 55.40  E-value: 9.54e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 1796787041   795 CDCDTAGSLPGTvCNAKTGQCICKPNVEGRQCNKCLEGNF 834
Cdd:smart00180    1 CDCDPGGSASGT-CDPDTGQCECKPNVTGRRCDRCAPGYY 39
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
847-897 1.44e-09

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 55.01  E-value: 1.44e-09
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|.
gi 1796787041   847 CNCDKTGTINGSllCNKSTGQCPCKLGVTGLRCNQCEPHRYNltiDNFQHC 897
Cdd:smart00180    1 CDCDPGGSASGT--CDPDTGQCECKPNVTGRRCDRCAPGYYG---DGPPGC 46
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 846-898 1.77e-09

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 54.67  E-value: 1.77e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1796787041  846 PCNCDKTGTINGSllCNKSTGQCPCKLGVTGLRCNQCEPHRYNLTiDNFQHCQ 898
Cdd:cd00055      1 PCDCNGHGSLSGQ--CDPGTGQCECKPNTTGRRCDRCAPGYYGLP-SQGGGCQ 50
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 847-897 2.36e-09

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 54.28  E-value: 2.36e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1796787041  847 CNCDKTGTINGSllCNKSTGQCPCKLGVTGLRCNQCEPHRYNLTIDNFQHC 897
Cdd:pfam00053    1 CDCNPHGSLSDT--CDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
951-996 2.39e-09

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 54.24  E-value: 2.39e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 1796787041   951 CSCHTTGAVNHICNSLTGQCVCQDAsIAGQRCDQCKDHYFGFDPQT 996
Cdd:smart00180    1 CDCDPGGSASGTCDPDTGQCECKPN-VTGRRCDRCAPGYYGDGPPG 45
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 795-844 6.99e-09

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 53.13  E-value: 6.99e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1796787041  795 CDCDTAGSLPGTvCNAKTGQCICKPNVEGRQCNKCLEGNFYLRQNNSFLC 844
Cdd:pfam00053    1 CDCNPHGSLSDT-CDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 951-998 9.19e-09

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 52.74  E-value: 9.19e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1796787041  951 CSCHTTGAVNHICNSLTGQCVCQDaSIAGQRCDQCKDHYFGFDPQTGR 998
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKP-GVTGRHCDRCKPGYYGLPSDPPQ 47
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1001-1037 9.70e-09

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 52.74  E-value: 9.70e-09
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1796787041 1001 PCNCHLSGALNETCHLVTGQCFCKQFVTGSKCDACVP 1037
Cdd:cd00055      1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAP 37
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
694-733 1.57e-08

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 51.93  E-value: 1.57e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 1796787041   694 CNCNTSGTVDGdiTCHQNSGQCKCKANVIGLRCDHCNFGF 733
Cdd:smart00180    1 CDCDPGGSASG--TCDPDTGQCECKPNVTGRRCDRCAPGY 38
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 693-745 1.94e-08

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 51.97  E-value: 1.94e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1796787041  693 PCNCNTSGTVDGdiTCHQNSGQCKCKANVIGLRCDHCNFGFkFLRSFNDVGCE 745
Cdd:cd00055      1 PCDCNGHGSLSG--QCDPGTGQCECKPNTTGRRCDRCAPGY-YGLPSQGGGCQ 50
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 694-744 6.03e-08

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 50.43  E-value: 6.03e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1796787041  694 CNCNTSGTVDGdiTCHQNSGQCKCKANVIGLRCDHCNFGFKFLRSFNDVGC 744
Cdd:pfam00053    1 CDCNPHGSLSD--TCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1002-1037 8.09e-08

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 50.04  E-value: 8.09e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1796787041 1002 CNCHLSGALNETCHLVTGQCFCKQFVTGSKCDACVP 1037
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKP 36
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1002-1037 8.88e-08

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 49.62  E-value: 8.88e-08
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 1796787041  1002 CNCHLSGALNETCHLVTGQCFCKQFVTGSKCDACVP 1037
Cdd:smart00180    1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAP 36
fn3 pfam00041
Fibronectin type III domain;
1058-1132 1.91e-06

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 47.41  E-value: 1.91e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796787041 1058 PPPRG---QVQSSSAINLSWSPPDSPNAHWLTYSLlrdgfeIYTTEDQYPYSIQYFLD--------TDLLPYTKYSYYIE 1126
Cdd:pfam00041    1 SAPSNltvTDVTSTSLTVSWTPPPDGNGPITGYEV------EYRPKNSGEPWNEITVPgtttsvtlTGLKPGTEYEVRVQ 74


                   ....*.
gi 1796787041 1127 TTNVHG 1132
Cdd:pfam00041   75 AVNGGG 80
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1058-1143 3.81e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 44.02  E-value: 3.81e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796787041 1058 PPPRG---QVQSSSAINLSWSPPDSPNAHWLTYSLLR--DGFEIYTTEDQYPYSIQYFLDTDLLPYTKYSYYIETTNVHG 1132
Cdd:cd00063      2 SPPTNlrvTDVTSTSVTLSWTPPEDDGGPITGYVVEYreKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                           90
                   ....*....|..
gi 1796787041 1133 -STRSVAVTYKT 1143
Cdd:cd00063     82 eSPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1058-1133 1.20e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 42.22  E-value: 1.20e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796787041  1058 PPPRGQVQ----SSSAINLSWSPPDSPNAHW--LTYSLLRDGFEIYTTEDQYPYSIQYFLDTDLLPYTKYSYYIETTNVH 1131
Cdd:smart00060    1 PSPPSNLRvtdvTSTSVTLSWEPPPDDGITGyiVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80


                    ..
gi 1796787041  1132 GS 1133
Cdd:smart00060   81 GE 82
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 574-639 4.16e-04

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 39.64  E-value: 4.16e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1796787041  574 PCQCNSH---SKSCHYnisvdpfpfehfrgGGGVCDdCEHNTTGRNCELCKDYFFRqvgaDPSAIDVCK 639
Cdd:cd00055      1 PCDCNGHgslSGQCDP--------------GTGQCE-CKPNTTGRRCDRCAPGYYG----LPSQGGGCQ 50
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 517-565 3.78e-03

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 36.95  E-value: 3.78e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1796787041  517 RCQCHGHAD---NCDTTSqpYRCLCsqESFTEGLHCDRCLPLYNDKPFRQGD 565
Cdd:cd00055      1 PCDCNGHGSlsgQCDPGT--GQCEC--KPNTTGRRCDRCAPGYYGLPSQGGG 48
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
575-629 6.69e-03

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 36.14  E-value: 6.69e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*...
gi 1796787041   575 CQCN---SHSKSCHYNisvdpfpfehfrggGGVCDdCEHNTTGRNCELCKDYFFRQVG 629
Cdd:smart00180    1 CDCDpggSASGTCDPD--------------TGQCE-CKPNVTGRRCDRCAPGYYGDGP 43
 
Name Accession Description Interval E-value
LamGL smart00560
LamG-like jellyroll fold domain;
146-283 1.02e-36

LamG-like jellyroll fold domain;


Pssm-ID: 214722 [Multi-domain]  Cd Length: 133  Bit Score: 135.24  E-value: 1.02e-36
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796787041   146 ASFTLAVWLKPEQQGVMCVIEKtvdGQIVFKLTISEKETMFYYRTV--NGLQPPIKVMTLGRIlvKKWIHLSVQVHQ--T 221
Cdd:smart00560    1 GSFTLEAWVKLESAGGSQPIIT---GAAVAQPTISEKALTFFLRAKsvQGWQTARTGATADWI--GVWVHLAGVYDGgaG 75

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1796787041   222 KISFFINGVEKDHTPFnarTLSGSITDFASGTvQIGQSLNGLEQFVGRMQDFRLYQVALTNR 283
Cdd:smart00560   76 KLSLYVNGVEVATSET---QPSPSSGNLPQGG-RILLGGAGGENFSGRLDEVRVYNRALTAR 133
Laminin_N pfam00055
Laminin N-terminal (Domain VI);
291-516 5.63e-29

Laminin N-terminal (Domain VI);


Pssm-ID: 459653  Cd Length: 230  Bit Score: 116.53  E-value: 5.63e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796787041  291 GDLL---RLHAQSHCrcpGSHPRvhplaQRYCIPNDAG-----DTADNRVSRLnpeAHPLSFV---NDNDVGTSWVSNvf 359
Cdd:pfam00055    6 GNLAfgrEVSATSTC---GLNGP-----ERYCILSGLEggkkcFICDSRDPHN---SHPPSNLtdsNNGTNETWWQSE-- 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796787041  360 TNITQLNQgVTISVDLEnGQYQVFYIIIQFFSPQPTEIRIQRKKENSLDWEDWQYFARNC-GAFGMKNNGDLE-KPDSVN 437
Cdd:pfam00055   73 TGVIQYEN-VNLTLDLG-KEFHFTYLILKFKSPRPAAMVLERSTDFGKTWQPYQYFASDCrRTFGRPSGPSRGiKDDEVI 150

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796787041  438 CLQL-SNFTPYSRGNVTFSILtpgpNYRPGYNNFYNTPSLQEFVKATQIRFHFH-----GQYYTTETAVNLRHrYYAVDE 511
Cdd:pfam00055  151 CTSEySDISPLTGGEVIFSTL----EGRPSANIFDYSPELQDWLTATNIRIRLLrlhtlGDELLDDPSVLRKY-YYAISD 225


                   ....*
gi 1796787041  512 ITISG 516
Cdd:pfam00055  226 ISVGG 230
LamNT smart00136
Laminin N-terminal domain (domain VI); N-terminal domain of laminins and laminin-related ...
 313-516 1.36e-21

Laminin N-terminal domain (domain VI); N-terminal domain of laminins and laminin-related protein such as Unc-6/ netrins.


Pssm-ID: 214532  Cd Length: 238  Bit Score: 95.50  E-value: 1.36e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796787041   313 PLAQRYCIPNDAG------DTADNRVSRLNpeaHPLSFV---NDNDVGTSWVSnvfTNITQLNQGVTISVDLENgQYQVF 383
Cdd:smart00136   29 PGPERYCKLVGHTeqgkkcDYCDARNPRRS---HPAENLtdgNNPNNPTWWQS---EPLSNGPQNVNLTLDLGK-EFHVT 101

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796787041   384 YIIIQFFSPQPTEIRIQRKKENSlDWEDWQYFARNCGA-FGMKNNGDLEKP--DSVNCL-QLSNFTPYSRGNVTFSILTP 459
Cdd:smart00136  102 YVILKFCSPRPSLWILERSDFGK-TWQPWQYFSSDCRRtFGRPPRGPITKGneDEVICTsEYSDIVPLEGGEIAFSLLEG 180

                           170       180       190       200       210       220
                    ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1796787041   460 gpnyRPGYNNFYNTPSLQEFVKATQIRFHFH-----GQYYTTETAVNLRHRYYAVDEITISG 516
Cdd:smart00136  181 ----RPSATDFDNSPVLQEWVTATNIRVRLTrlrtlGDELMDDRPEVTRRYYYAISDIAVGG 238
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1103-1469 5.46e-14

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 76.96  E-value: 5.46e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796787041 1103 YPYSIQYFLDTDLLPYTKYSYYIETTNVHGSTrsvAVTYKTKPGVPEGNLTLSYIIPIGSDSVTLTWTTLSNQSGPIEKY 1182
Cdd:COG3401     93 GLTTLTGSGSVGGATNTGLTSSDEVPSPAVGT---ATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVV 169

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796787041 1183 IlscAPLAGGQPCVSYEGHETSATIW-----NLVPFAKYDFSVQACTSGGC-LHSLPITVTTAQAPPQRLSPPKMQKISS 1256
Cdd:COG3401    170 V---SPDTSATAAVATTSLTVTSTTLvdgggDIEPGTTYYYRVAATDTGGEsAPSNEVSVTTPTTPPSAPTGLTATADTP 246

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796787041 1257 TELHVEWSPPAELNgiIIRYELYmrrlRSTKettseesrvfqssgwlSPHSFVESANENAlkppqTMTTITGLEPYTKYE 1336
Cdd:COG3401    247 GSVTLSWDPVTESD--ATGYRVY----RSNS----------------GDGPFTKVATVTT-----TSYTDTGLTNGTTYY 299

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796787041 1337 FRVLAVNMAGSVS--SAWVSERTGESAPvfmIPPSVF---PLSSYSLNISWEKPADNvtrgKVVGYDInmlsEQSPQQSI 1411
Cdd:COG3401    300 YRVTAVDAAGNESapSNVVSVTTDLTPP---AAPSGLtatAVGSSSITLSWTASSDA----DVTGYNV----YRSTSGGG 368

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1796787041 1412 PmaFSQLLHTAKsqELSYTVEGLKPYRIYEFTITLCNSVGCVTSASGAGQTLAAAPAQ 1469
Cdd:COG3401    369 T--YTKIAETVT--TTSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEVSATTASAAS 422
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1242-1357 5.63e-14

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 69.06  E-value: 5.63e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796787041 1242 PPQRLsppKMQKISSTELHVEWSPPAELNGIIIRYELYMRRLRSTKETTSEESRvfqssgwlsphsfvesanenalkPPQ 1321
Cdd:cd00063      3 PPTNL---RVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTP-----------------------GSE 56

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1796787041 1322 TMTTITGLEPYTKYEFRVLAVNMAG-SVSSAWVSERT 1357
Cdd:cd00063     57 TSYTLTGLKPGTEYEFRVRAVNGGGeSPPSESVTVTT 93
Laminin_G_3 pfam13385
Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin ...
 146-285 8.24e-14

Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin A-like lectin/glucanases superfamily.


Pssm-ID: 463865 [Multi-domain]  Cd Length: 151  Bit Score: 70.49  E-value: 8.24e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796787041  146 ASFTLAVWLKPEQ--QGVMCVIEKTVDGQIVFKLTiSEKETMFYYRTVNGLqpPIKVMTLGRILVKKWIHLSVQVHQTKI 223
Cdd:pfam13385   17 SDFTVSAWVKPDSlpGWARAIISSSGGGGYSLGLD-GDGRLRFAVNGGNGG--WDTVTSGASVPLGQWTHVAVTYDGGTL 93

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1796787041  224 SFFINGVEKDhtpfnARTLSGSITDFASGTVQIGQSLNGLEQFVGRMQDFRLYQVALTNREI 285
Cdd:pfam13385   94 RLYVNGVLVG-----SSTLTGGPPPGTGGPLYIGRSPGGDDYFNGLIDEVRIYDRALSAAEI 150
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1145-1238 1.90e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 67.52  E-value: 1.90e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796787041 1145 PGVPEgNLTLSyiiPIGSDSVTLTWTTLSNQSGPIEKYILSCAPLAGGQP--CVSYEGHETSATIWNLVPFAKYDFSVQA 1222
Cdd:cd00063      1 PSPPT-NLRVT---DVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWkeVEVTPGSETSYTLTGLKPGTEYEFRVRA 76

                           90
                   ....*....|....*..
gi 1796787041 1223 CTSGGC-LHSLPITVTT 1238
Cdd:cd00063     77 VNGGGEsPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
1150-1227 3.87e-13

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 66.28  E-value: 3.87e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796787041 1150 GNLTlsyIIPIGSDSVTLTWTTLSNQSGPIEKYILSCAPLAGGQPCVSYE--GHETSATIWNLVPFAKYDFSVQACTSGG 1227
Cdd:pfam00041    4 SNLT---VTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEITvpGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1051-1243 1.49e-12

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 72.34  E-value: 1.49e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796787041 1051 SKTPFQQPPP-----RGQVQSSSAINLSWSPPDSPNAhwltysllrDGFEIY-TTEDQYPYSI------QYFLDTDLLPY 1118
Cdd:COG3401    225 SVTTPTTPPSaptglTATADTPGSVTLSWDPVTESDA---------TGYRVYrSNSGDGPFTKvatvttTSYTDTGLTNG 295

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796787041 1119 TKYSYYIETTNVHG--STRSVAV---TYKTKPGVPEgNLTLSYiipIGSDSVTLTWTtlSNQSGPIEKYILSCAPLAGGQ 1193
Cdd:COG3401    296 TTYYYRVTAVDAAGneSAPSNVVsvtTDLTPPAAPS-GLTATA---VGSSSITLSWT--ASSDADVTGYNVYRSTSGGGT 369

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1796787041 1194 PCVSYEGH-ETSATIWNLVPFAKYDFSVQACTSGGC--LHSLPITVTTAQAPP 1243
Cdd:COG3401    370 YTKIAETVtTTSYTDTGLTPGTTYYYKVTAVDAAGNesAPSEEVSATTASAAS 422
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 900-948 8.99e-12

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 61.22  E-value: 8.99e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1796787041  900 CECDSLGTLPGTiCDPISGQCLCVPNRQGRRCNQCQPGFYISPGNATGC 948
Cdd:cd00055      2 CDCNGHGSLSGQ-CDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQGGGC 49
fn3 pfam00041
Fibronectin type III domain;
1242-1346 1.23e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.05  E-value: 1.23e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796787041 1242 PPQRLSppkMQKISSTELHVEWSPPAELNGIIIRYELymrrlrsTKETTSEESRVFQSSgwlsphsfvesanenaLKPPQ 1321
Cdd:pfam00041    2 APSNLT---VTDVTSTSLTVSWTPPPDGNGPITGYEV-------EYRPKNSGEPWNEIT----------------VPGTT 55

                           90       100
                   ....*....|....*....|....*
gi 1796787041 1322 TMTTITGLEPYTKYEFRVLAVNMAG 1346
Cdd:pfam00041   56 TSVTLTGLKPGTEYEVRVQAVNGGG 80
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 900-948 2.50e-11

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 60.06  E-value: 2.50e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1796787041  900 CECDSLGTLPGTiCDPISGQCLCVPNRQGRRCNQCQPGFY-ISPGNATGC 948
Cdd:pfam00053    1 CDCNPHGSLSDT-CDPETGQCLCKPGVTGRHCDRCKPGYYgLPSDPPQGC 49
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 641-691 2.84e-11

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 59.67  E-value: 2.84e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1796787041  641 CDCDTVGTRNGSilCDQIGGQCNCKRHVSGRQCNQCQNGFYNLQELDPDGC 691
Cdd:pfam00053    1 CDCNPHGSLSDT--CDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
900-944 2.94e-11

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 59.63  E-value: 2.94e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 1796787041   900 CECDSLGTLPGTiCDPISGQCLCVPNRQGRRCNQCQPGFYISPGN 944
Cdd:smart00180    1 CDCDPGGSASGT-CDPDTGQCECKPNVTGRRCDRCAPGYYGDGPP 44
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 950-1000 4.88e-11

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 59.29  E-value: 4.88e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1796787041  950 PCSCHTTGAVNHICNSLTGQCVCQDAsIAGQRCDQCKDHYFGFDPQTGRCQ 1000
Cdd:cd00055      1 PCDCNGHGSLSGQCDPGTGQCECKPN-TTGRRCDRCAPGYYGLPSQGGGCQ 50
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 747-795 5.51e-11

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 58.90  E-value: 5.51e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1796787041  747 CQCNLHGSVNKFCNPHSGQCECKKEAKGLQCDTCRENFYGLDVTNCKAC 795
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 640-691 6.29e-11

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 58.90  E-value: 6.29e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1796787041  640 PCDCDTVGTRNGSilCDQIGGQCNCKRHVSGRQCNQCQNGFYNLQElDPDGC 691
Cdd:cd00055      1 PCDCNGHGSLSGQ--CDPGTGQCECKPNTTGRRCDRCAPGYYGLPS-QGGGC 49
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1242-1347 9.05e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 59.55  E-value: 9.05e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796787041  1242 PPQRLsppKMQKISSTELHVEWSPPAELNGI--IIRYELYMRRLRSTKETTSEesrvfqssgwlsphsfvesanenalKP 1319
Cdd:smart00060    3 PPSNL---RVTDVTSTSVTLSWEPPPDDGITgyIVGYRVEYREEGSEWKEVNV-------------------------TP 54

                            90       100
                    ....*....|....*....|....*...
gi 1796787041  1320 PQTMTTITGLEPYTKYEFRVLAVNMAGS 1347
Cdd:smart00060   55 SSTSYTLTGLKPGTEYEFRVRAVNGAGE 82
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 746-788 9.12e-11

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 58.52  E-value: 9.12e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1796787041  746 PCQCNLHGSVNKFCNPHSGQCECKKEAKGLQCDTCRENFYGLD 788
Cdd:cd00055      1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLP 43
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
641-691 2.03e-10

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 57.32  E-value: 2.03e-10
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|.
gi 1796787041   641 CDCDTVGTRNGSilCDQIGGQCNCKRHVSGRQCNQCQNGFYNlqeLDPDGC 691
Cdd:smart00180    1 CDCDPGGSASGT--CDPDTGQCECKPNVTGRRCDRCAPGYYG---DGPPGC 46
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1368-1451 2.57e-10

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 58.39  E-value: 2.57e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796787041  1368 PSVFPLSSYSLNISWEKPADNVTRGKVVGYDINMLSEQSPQQSIpmafsqllhTAKSQELSYTVEGLKPYRIYEFTITLC 1447
Cdd:smart00060    7 LRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEV---------NVTPSSTSYTLTGLKPGTEYEFRVRAV 77


                    ....
gi 1796787041  1448 NSVG 1451
Cdd:smart00060   78 NGAG 81
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
747-792 5.46e-10

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 56.17  E-value: 5.46e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 1796787041   747 CQCNLHGSVNKFCNPHSGQCECKKEAKGLQCDTCRENFYGLDVTNC 792
Cdd:smart00180    1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDGPPGC 46
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 794-836 7.69e-10

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 55.82  E-value: 7.69e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1796787041  794 ACDCDTAGSLPGTvCNAKTGQCICKPNVEGRQCNKCLEGNFYL 836
Cdd:cd00055      1 PCDCNGHGSLSGQ-CDPGTGQCECKPNTTGRRCDRCAPGYYGL 42
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
795-834 9.54e-10

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 55.40  E-value: 9.54e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 1796787041   795 CDCDTAGSLPGTvCNAKTGQCICKPNVEGRQCNKCLEGNF 834
Cdd:smart00180    1 CDCDPGGSASGT-CDPDTGQCECKPNVTGRRCDRCAPGYY 39
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1145-1227 1.04e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 56.47  E-value: 1.04e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796787041  1145 PGVPEgNLTLSyiiPIGSDSVTLTWT--TLSNQSGPIEKYILSCAPLAGGQPCVSYEGHETSATIWNLVPFAKYDFSVQA 1222
Cdd:smart00060    1 PSPPS-NLRVT---DVTSTSVTLSWEppPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRA 76


                    ....*
gi 1796787041  1223 CTSGG 1227
Cdd:smart00060   77 VNGAG 81
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
847-897 1.44e-09

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 55.01  E-value: 1.44e-09
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|.
gi 1796787041   847 CNCDKTGTINGSllCNKSTGQCPCKLGVTGLRCNQCEPHRYNltiDNFQHC 897
Cdd:smart00180    1 CDCDPGGSASGT--CDPDTGQCECKPNVTGRRCDRCAPGYYG---DGPPGC 46
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 846-898 1.77e-09

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 54.67  E-value: 1.77e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1796787041  846 PCNCDKTGTINGSllCNKSTGQCPCKLGVTGLRCNQCEPHRYNLTiDNFQHCQ 898
Cdd:cd00055      1 PCDCNGHGSLSGQ--CDPGTGQCECKPNTTGRRCDRCAPGYYGLP-SQGGGCQ 50
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 847-897 2.36e-09

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 54.28  E-value: 2.36e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1796787041  847 CNCDKTGTINGSllCNKSTGQCPCKLGVTGLRCNQCEPHRYNLTIDNFQHC 897
Cdd:pfam00053    1 CDCNPHGSLSDT--CDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
951-996 2.39e-09

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 54.24  E-value: 2.39e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 1796787041   951 CSCHTTGAVNHICNSLTGQCVCQDAsIAGQRCDQCKDHYFGFDPQT 996
Cdd:smart00180    1 CDCDPGGSASGTCDPDTGQCECKPN-VTGRRCDRCAPGYYGDGPPG 45
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 795-844 6.99e-09

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 53.13  E-value: 6.99e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1796787041  795 CDCDTAGSLPGTvCNAKTGQCICKPNVEGRQCNKCLEGNFYLRQNNSFLC 844
Cdd:pfam00053    1 CDCNPHGSLSDT-CDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 951-998 9.19e-09

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 52.74  E-value: 9.19e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1796787041  951 CSCHTTGAVNHICNSLTGQCVCQDaSIAGQRCDQCKDHYFGFDPQTGR 998
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKP-GVTGRHCDRCKPGYYGLPSDPPQ 47
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1001-1037 9.70e-09

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 52.74  E-value: 9.70e-09
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1796787041 1001 PCNCHLSGALNETCHLVTGQCFCKQFVTGSKCDACVP 1037
Cdd:cd00055      1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAP 37
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
694-733 1.57e-08

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 51.93  E-value: 1.57e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 1796787041   694 CNCNTSGTVDGdiTCHQNSGQCKCKANVIGLRCDHCNFGF 733
Cdd:smart00180    1 CDCDPGGSASG--TCDPDTGQCECKPNVTGRRCDRCAPGY 38
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 693-745 1.94e-08

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 51.97  E-value: 1.94e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1796787041  693 PCNCNTSGTVDGdiTCHQNSGQCKCKANVIGLRCDHCNFGFkFLRSFNDVGCE 745
Cdd:cd00055      1 PCDCNGHGSLSG--QCDPGTGQCECKPNTTGRRCDRCAPGY-YGLPSQGGGCQ 50
fn3 pfam00041
Fibronectin type III domain;
1368-1451 3.13e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 52.42  E-value: 3.13e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796787041 1368 PSVFPLSSYSLNISWEKPADNvtRGKVVGYDI--NMLSEQSPQQSIpmafsqllhTAKSQELSYTVEGLKPYRIYEFTIT 1445
Cdd:pfam00041    6 LTVTDVTSTSLTVSWTPPPDG--NGPITGYEVeyRPKNSGEPWNEI---------TVPGTTTSVTLTGLKPGTEYEVRVQ 74


                   ....*.
gi 1796787041 1446 LCNSVG 1451
Cdd:pfam00041   75 AVNGGG 80
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1368-1451 3.45e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 52.50  E-value: 3.45e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796787041 1368 PSVFPLSSYSLNISWEKPADNvtRGKVVGYDINMLSEQSPQqsipmafSQLLHTAKSQELSYTVEGLKPYRIYEFTITLC 1447
Cdd:cd00063      7 LRVTDVTSTSVTLSWTPPEDD--GGPITGYVVEYREKGSGD-------WKEVEVTPGSETSYTLTGLKPGTEYEFRVRAV 77


                   ....
gi 1796787041 1448 NSVG 1451
Cdd:cd00063     78 NGGG 81
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 694-744 6.03e-08

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 50.43  E-value: 6.03e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1796787041  694 CNCNTSGTVDGdiTCHQNSGQCKCKANVIGLRCDHCNFGFKFLRSFNDVGC 744
Cdd:pfam00053    1 CDCNPHGSLSD--TCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1002-1037 8.09e-08

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 50.04  E-value: 8.09e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1796787041 1002 CNCHLSGALNETCHLVTGQCFCKQFVTGSKCDACVP 1037
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKP 36
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1002-1037 8.88e-08

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 49.62  E-value: 8.88e-08
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 1796787041  1002 CNCHLSGALNETCHLVTGQCFCKQFVTGSKCDACVP 1037
Cdd:smart00180    1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAP 36
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1053-1184 1.46e-07

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 56.16  E-value: 1.46e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796787041 1053 TPFQQPPP-----RGQVQSSSAINLSWSPPDSPNAHwlTYSLLRDGFE------IYTTEDQYPYSiqyflDTDLLPYTKY 1121
Cdd:COG3401    321 TTDLTPPAapsglTATAVGSSSITLSWTASSDADVT--GYNVYRSTSGggtytkIAETVTTTSYT-----DTGLTPGTTY 393

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1796787041 1122 SYYIETTNVHG--STRSVAVTYKTKPGVPEGNLTLSYIIPIGSDSVTLTWTTLSNQSGPIEKYIL 1184
Cdd:COG3401    394 YYKVTAVDAAGneSAPSEEVSATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVL 458
fn3 pfam00041
Fibronectin type III domain;
1058-1132 1.91e-06

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 47.41  E-value: 1.91e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796787041 1058 PPPRG---QVQSSSAINLSWSPPDSPNAHWLTYSLlrdgfeIYTTEDQYPYSIQYFLD--------TDLLPYTKYSYYIE 1126
Cdd:pfam00041    1 SAPSNltvTDVTSTSLTVSWTPPPDGNGPITGYEV------EYRPKNSGEPWNEITVPgtttsvtlTGLKPGTEYEVRVQ 74


                   ....*.
gi 1796787041 1127 TTNVHG 1132
Cdd:pfam00041   75 AVNGGG 80
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1058-1143 3.81e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 44.02  E-value: 3.81e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796787041 1058 PPPRG---QVQSSSAINLSWSPPDSPNAHWLTYSLLR--DGFEIYTTEDQYPYSIQYFLDTDLLPYTKYSYYIETTNVHG 1132
Cdd:cd00063      2 SPPTNlrvTDVTSTSVTLSWTPPEDDGGPITGYVVEYreKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                           90
                   ....*....|..
gi 1796787041 1133 -STRSVAVTYKT 1143
Cdd:cd00063     82 eSPPSESVTVTT 93
Pur_ac_phosph_N pfam16656
Purple acid Phosphatase, N-terminal domain; This domain is found at the N-terminus of Purple ...
 1256-1357 3.96e-05

Purple acid Phosphatase, N-terminal domain; This domain is found at the N-terminus of Purple acid phosphatase proteins.


Pssm-ID: 465220 [Multi-domain]  Cd Length: 93  Bit Score: 43.94  E-value: 3.96e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796787041 1256 STELHVEWSPPAELNGIIIRYELYMRRLRSTKETTSEE-SRVFQSSGWLspHSFvesanenalkppqtmtTITGLEPYTK 1334
Cdd:pfam16656   12 STSMTVSWVTPSAVTSPVVQYGTSSSALTSTATATSSTyTTGDGGTGYI--HRA----------------TLTGLEPGTT 73

                           90       100
                   ....*....|....*....|...
gi 1796787041 1335 YEFRVLAvnmAGSVSSAWVSERT 1357
Cdd:pfam16656   74 YYYRVGD---DNGGWSEVYSFTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1058-1133 1.20e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 42.22  E-value: 1.20e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1796787041  1058 PPPRGQVQ----SSSAINLSWSPPDSPNAHW--LTYSLLRDGFEIYTTEDQYPYSIQYFLDTDLLPYTKYSYYIETTNVH 1131
Cdd:smart00060    1 PSPPSNLRvtdvTSTSVTLSWEPPPDDGITGyiVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80


                    ..
gi 1796787041  1132 GS 1133
Cdd:smart00060   81 GE 82
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 574-639 4.16e-04

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 39.64  E-value: 4.16e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1796787041  574 PCQCNSH---SKSCHYnisvdpfpfehfrgGGGVCDdCEHNTTGRNCELCKDYFFRqvgaDPSAIDVCK 639
Cdd:cd00055      1 PCDCNGHgslSGQCDP--------------GTGQCE-CKPNTTGRRCDRCAPGYYG----LPSQGGGCQ 50
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 517-565 3.78e-03

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 36.95  E-value: 3.78e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1796787041  517 RCQCHGHAD---NCDTTSqpYRCLCsqESFTEGLHCDRCLPLYNDKPFRQGD 565
Cdd:cd00055      1 PCDCNGHGSlsgQCDPGT--GQCEC--KPNTTGRRCDRCAPGYYGLPSQGGG 48
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
575-629 6.69e-03

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 36.14  E-value: 6.69e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*...
gi 1796787041   575 CQCN---SHSKSCHYNisvdpfpfehfrggGGVCDdCEHNTTGRNCELCKDYFFRQVG 629
Cdd:smart00180    1 CDCDpggSASGTCDPD--------------TGQCE-CKPNVTGRRCDRCAPGYYGDGP 43
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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