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Conserved domains on  [gi|115511046|ref|NP_009098|]
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zinc finger MYM-type protein 6 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 134-174 7.01e-07

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


:

Pssm-ID: 428958  Cd Length: 40  Bit Score: 46.98  E-value: 7.01e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 115511046   134 PKKTCTNCSKDILNPKDVITTRFENSypSKDFCSQSCLSSY 174
Cdd:pfam06467    2 VKATCWFCKKLIKNKPTVIVLQNDGS--VGQFCSQSCLDSY 40
DUF4371 super family cl46273
Domain of unknown function (DUF4371);
873-992 5.51e-04

Domain of unknown function (DUF4371);


The actual alignment was detected with superfamily member pfam14291:

Pssm-ID: 480613  Cd Length: 236  Bit Score: 42.99  E-value: 5.51e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115511046   873 MKTIPLSNVTIQHRIDE-----LSADIEDQLIQKVrESKWFALQIDESSEISNITLLLCYIRFIDyDCRDVKEELLFCIE 947
Cdd:pfam14291  115 LKNAPKNNTYTSPPIQNdivncFSNEVTRSIIEEM-DNDVFGILVDETADASDKEQMAIVFRYVD-KYGVPIERFIGVIH 192

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 115511046   948 MpTQITGFEIFELINKYIDSKSLNWKHCVGLCTDGAASMTGRYSG 992
Cdd:pfam14291  193 V-QETSSLSLKSAIDSLLKSLGISLKKLRSQCYDGASNMSGEFNG 236
TRASH smart00746
metallochaperone-like domain;
193-228 1.91e-03

metallochaperone-like domain;


:

Pssm-ID: 214799  Cd Length: 39  Bit Score: 37.36  E-value: 1.91e-03
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 115511046    193 CSMCQKNADTRFEVKYQNVVHGLCSDACFSKFHSTN 228
Cdd:smart00746    4 CGKDIYNPGTGIMVVNDGKVYYFCSSKCLSKFKKKR 39
 
Name Accession Description Interval E-value
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 134-174 7.01e-07

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


Pssm-ID: 428958  Cd Length: 40  Bit Score: 46.98  E-value: 7.01e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 115511046   134 PKKTCTNCSKDILNPKDVITTRFENSypSKDFCSQSCLSSY 174
Cdd:pfam06467    2 VKATCWFCKKLIKNKPTVIVLQNDGS--VGQFCSQSCLDSY 40
TRASH smart00746
metallochaperone-like domain;
138-178 1.73e-04

metallochaperone-like domain;


Pssm-ID: 214799  Cd Length: 39  Bit Score: 40.05  E-value: 1.73e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 115511046    138 CTNCSKDILNPKDVITTRFENSypSKDFCSQSCLSSYELKK 178
Cdd:smart00746    1 CSFCGKDIYNPGTGIMVVNDGK--VYYFCSSKCLSKFKKKR 39
DUF4371 pfam14291
Domain of unknown function (DUF4371);
873-992 5.51e-04

Domain of unknown function (DUF4371);


Pssm-ID: 405048  Cd Length: 236  Bit Score: 42.99  E-value: 5.51e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115511046   873 MKTIPLSNVTIQHRIDE-----LSADIEDQLIQKVrESKWFALQIDESSEISNITLLLCYIRFIDyDCRDVKEELLFCIE 947
Cdd:pfam14291  115 LKNAPKNNTYTSPPIQNdivncFSNEVTRSIIEEM-DNDVFGILVDETADASDKEQMAIVFRYVD-KYGVPIERFIGVIH 192

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 115511046   948 MpTQITGFEIFELINKYIDSKSLNWKHCVGLCTDGAASMTGRYSG 992
Cdd:pfam14291  193 V-QETSSLSLKSAIDSLLKSLGISLKKLRSQCYDGASNMSGEFNG 236
TRASH smart00746
metallochaperone-like domain;
193-228 1.91e-03

metallochaperone-like domain;


Pssm-ID: 214799  Cd Length: 39  Bit Score: 37.36  E-value: 1.91e-03
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 115511046    193 CSMCQKNADTRFEVKYQNVVHGLCSDACFSKFHSTN 228
Cdd:smart00746    4 CGKDIYNPGTGIMVVNDGKVYYFCSSKCLSKFKKKR 39
 
Name Accession Description Interval E-value
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 134-174 7.01e-07

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


Pssm-ID: 428958  Cd Length: 40  Bit Score: 46.98  E-value: 7.01e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 115511046   134 PKKTCTNCSKDILNPKDVITTRFENSypSKDFCSQSCLSSY 174
Cdd:pfam06467    2 VKATCWFCKKLIKNKPTVIVLQNDGS--VGQFCSQSCLDSY 40
TRASH smart00746
metallochaperone-like domain;
138-178 1.73e-04

metallochaperone-like domain;


Pssm-ID: 214799  Cd Length: 39  Bit Score: 40.05  E-value: 1.73e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 115511046    138 CTNCSKDILNPKDVITTRFENSypSKDFCSQSCLSSYELKK 178
Cdd:smart00746    1 CSFCGKDIYNPGTGIMVVNDGK--VYYFCSSKCLSKFKKKR 39
DUF4371 pfam14291
Domain of unknown function (DUF4371);
873-992 5.51e-04

Domain of unknown function (DUF4371);


Pssm-ID: 405048  Cd Length: 236  Bit Score: 42.99  E-value: 5.51e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115511046   873 MKTIPLSNVTIQHRIDE-----LSADIEDQLIQKVrESKWFALQIDESSEISNITLLLCYIRFIDyDCRDVKEELLFCIE 947
Cdd:pfam14291  115 LKNAPKNNTYTSPPIQNdivncFSNEVTRSIIEEM-DNDVFGILVDETADASDKEQMAIVFRYVD-KYGVPIERFIGVIH 192

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 115511046   948 MpTQITGFEIFELINKYIDSKSLNWKHCVGLCTDGAASMTGRYSG 992
Cdd:pfam14291  193 V-QETSSLSLKSAIDSLLKSLGISLKKLRSQCYDGASNMSGEFNG 236
TRASH smart00746
metallochaperone-like domain;
193-228 1.91e-03

metallochaperone-like domain;


Pssm-ID: 214799  Cd Length: 39  Bit Score: 37.36  E-value: 1.91e-03
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 115511046    193 CSMCQKNADTRFEVKYQNVVHGLCSDACFSKFHSTN 228
Cdd:smart00746    4 CGKDIYNPGTGIMVVNDGKVYYFCSSKCLSKFKKKR 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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