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Conserved domains on  [gi|148727341|ref|NP_009109|]
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serine-threonine kinase receptor-associated protein [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
4-294 8.00e-45

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 158.15  E-value: 8.00e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148727341   4 RQTPLTCSGHTRPVVDLAFSgitPYGYFLISACKDGKPMLRQGDTGDWIGTFLGHKGAVW-------GATLnkdatkaAT 76
Cdd:COG2319  110 GLLLRTLTGHTGAVRSVAFS---PDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTsvafspdGKLL-------AS 179

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148727341  77 AAADFTAKVWDAVSGDELMTL-AHKHIVKTVDFTQDSNYLLTGGQDKLLRIYDLNKPEaEPKEISGHTSGIKKALWCSED 155
Cdd:COG2319  180 GSDDGTVRLWDLATGKLLRTLtGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGK-LLRTLTGHSGSVRSVAFSPDG 258

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148727341 156 KQILSA-DDKTVRLWDHATMTEVKSLN-FNMSVSSMEYIPEGEILVIT-YGRSIAFHSAVSLDPIKSFEAP-ATINSASL 231
Cdd:COG2319  259 RLLASGsADGTVRLWDLATGELLRTLTgHSGGVNSVAFSPDGKLLASGsDDGTVRLWDLATGKLLRTLTGHtGAVRSVAF 338

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 148727341 232 HPEKEFLVAGGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSEDGTLRLWQT 294
Cdd:COG2319  339 SPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDL 401
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
4-294 8.00e-45

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 158.15  E-value: 8.00e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148727341   4 RQTPLTCSGHTRPVVDLAFSgitPYGYFLISACKDGKPMLRQGDTGDWIGTFLGHKGAVW-------GATLnkdatkaAT 76
Cdd:COG2319  110 GLLLRTLTGHTGAVRSVAFS---PDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTsvafspdGKLL-------AS 179

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148727341  77 AAADFTAKVWDAVSGDELMTL-AHKHIVKTVDFTQDSNYLLTGGQDKLLRIYDLNKPEaEPKEISGHTSGIKKALWCSED 155
Cdd:COG2319  180 GSDDGTVRLWDLATGKLLRTLtGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGK-LLRTLTGHSGSVRSVAFSPDG 258

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148727341 156 KQILSA-DDKTVRLWDHATMTEVKSLN-FNMSVSSMEYIPEGEILVIT-YGRSIAFHSAVSLDPIKSFEAP-ATINSASL 231
Cdd:COG2319  259 RLLASGsADGTVRLWDLATGELLRTLTgHSGGVNSVAFSPDGKLLASGsDDGTVRLWDLATGKLLRTLTGHtGAVRSVAF 338

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 148727341 232 HPEKEFLVAGGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSEDGTLRLWQT 294
Cdd:COG2319  339 SPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 9-293 3.52e-43

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 150.95  E-value: 3.52e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148727341   9 TCSGHTRPVVDLAFSGITPYgyfLISACKDGKPMLRQGDTGDWIGTFLGHKGAVWGATLNKDATKAATAAADFTAKVWDA 88
Cdd:cd00200    4 TLKGHTGGVTCVAFSPDGKL---LATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148727341  89 VSGDELMTLA-HKHIVKTVDFTQDSNYLLTGGQDKLLRIYDLNKPEAEpKEISGHTSGIKKALWCSEDKQILSA-DDKTV 166
Cdd:cd00200   81 ETGECVRTLTgHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCL-TTLRGHTDWVNSVAFSPDGTFVASSsQDGTI 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148727341 167 RLWDHATMTEVKSLN-FNMSVSSMEYIPEGEILVITYG-RSIAFHSAVSLDPIKSFEA-PATINSASLHPEKEFLVAGGE 243
Cdd:cd00200  160 KLWDLRTGKCVATLTgHTGEVNSVAFSPDGEKLLSSSSdGTIKLWDLSTGKCLGTLRGhENGVNSVAFSPDGYLLASGSE 239

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 148727341 244 DFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSEDGTLRLWQ 293
Cdd:cd00200  240 DGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 254-292 2.35e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 55.01  E-value: 2.35e-10
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 148727341   254 SGEELESYKGHFGPIHCVRFSPDGELYASGSEDGTLRLW 292
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
255-292 1.90e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 52.35  E-value: 1.90e-09
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 148727341  255 GEELESYKGHFGPIHCVRFSPDGELYASGSEDGTLRLW 292
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 97-292 4.83e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 45.08  E-value: 4.83e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148727341  97 LAHKHIVKTVDFTQDSNYLLTGGQDKLLRIYDLNKPEAEPKEIS------GHTSGIKKALWCSEDK-QILSAD-DKTVRL 168
Cdd:PLN00181 480 LNSSNLVCAIGFDRDGEFFATAGVNKKIKIFECESIIKDGRDIHypvvelASRSKLSGICWNSYIKsQVASSNfEGVVQV 559

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148727341 169 WDHAT---MTEVKSlnFNMSVSSMEYIPEGEILVIT-----YGRSIAFHSAVSLDPIKSfeaPATINSASLHPEK-EFLV 239
Cdd:PLN00181 560 WDVARsqlVTEMKE--HEKRVWSIDYSSADPTLLASgsddgSVKLWSINQGVSIGTIKT---KANICCVQFPSESgRSLA 634

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 148727341 240 AGGEDFKLYKYDY-NSGEELESYKGHFGPIHCVRFSpDGELYASGSEDGTLRLW 292
Cdd:PLN00181 635 FGSADHKVYYYDLrNPKLPLCTMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKLW 687
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
4-294 8.00e-45

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 158.15  E-value: 8.00e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148727341   4 RQTPLTCSGHTRPVVDLAFSgitPYGYFLISACKDGKPMLRQGDTGDWIGTFLGHKGAVW-------GATLnkdatkaAT 76
Cdd:COG2319  110 GLLLRTLTGHTGAVRSVAFS---PDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTsvafspdGKLL-------AS 179

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148727341  77 AAADFTAKVWDAVSGDELMTL-AHKHIVKTVDFTQDSNYLLTGGQDKLLRIYDLNKPEaEPKEISGHTSGIKKALWCSED 155
Cdd:COG2319  180 GSDDGTVRLWDLATGKLLRTLtGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGK-LLRTLTGHSGSVRSVAFSPDG 258

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148727341 156 KQILSA-DDKTVRLWDHATMTEVKSLN-FNMSVSSMEYIPEGEILVIT-YGRSIAFHSAVSLDPIKSFEAP-ATINSASL 231
Cdd:COG2319  259 RLLASGsADGTVRLWDLATGELLRTLTgHSGGVNSVAFSPDGKLLASGsDDGTVRLWDLATGKLLRTLTGHtGAVRSVAF 338

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 148727341 232 HPEKEFLVAGGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSEDGTLRLWQT 294
Cdd:COG2319  339 SPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
4-298 1.83e-44

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 157.38  E-value: 1.83e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148727341   4 RQTPLTCSGHTRPVVDLAFSgitPYGYFLISACKDGKPMLRQGDTGDWIGTFLGHKGAVWGATLNKDATKAATAAADFTA 83
Cdd:COG2319   68 GALLATLLGHTAAVLSVAFS---PDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTV 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148727341  84 KVWDAVSGDELMTL-AHKHIVKTVDFTQDSNYLLTGGQDKLLRIYDLNKPEaEPKEISGHTSGIKKALWCSEDKQILSA- 161
Cdd:COG2319  145 RLWDLATGKLLRTLtGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGK-LLRTLTGHTGAVRSVAFSPDGKLLASGs 223

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148727341 162 DDKTVRLWDHATMTEVKSLNF-NMSVSSMEYIPEGEILVIT-YGRSIAFHSAVSLDPIKSFEAP-ATINSASLHPEKEFL 238
Cdd:COG2319  224 ADGTVRLWDLATGKLLRTLTGhSGSVRSVAFSPDGRLLASGsADGTVRLWDLATGELLRTLTGHsGGVNSVAFSPDGKLL 303

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 148727341 239 VAGGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSEDGTLRLWQTVVGK 298
Cdd:COG2319  304 ASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGE 363
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 9-293 3.52e-43

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 150.95  E-value: 3.52e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148727341   9 TCSGHTRPVVDLAFSGITPYgyfLISACKDGKPMLRQGDTGDWIGTFLGHKGAVWGATLNKDATKAATAAADFTAKVWDA 88
Cdd:cd00200    4 TLKGHTGGVTCVAFSPDGKL---LATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148727341  89 VSGDELMTLA-HKHIVKTVDFTQDSNYLLTGGQDKLLRIYDLNKPEAEpKEISGHTSGIKKALWCSEDKQILSA-DDKTV 166
Cdd:cd00200   81 ETGECVRTLTgHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCL-TTLRGHTDWVNSVAFSPDGTFVASSsQDGTI 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148727341 167 RLWDHATMTEVKSLN-FNMSVSSMEYIPEGEILVITYG-RSIAFHSAVSLDPIKSFEA-PATINSASLHPEKEFLVAGGE 243
Cdd:cd00200  160 KLWDLRTGKCVATLTgHTGEVNSVAFSPDGEKLLSSSSdGTIKLWDLSTGKCLGTLRGhENGVNSVAFSPDGYLLASGSE 239

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 148727341 244 DFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSEDGTLRLWQ 293
Cdd:cd00200  240 DGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
4-299 3.50e-42

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 151.22  E-value: 3.50e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148727341   4 RQTPLTCSGHTRPVVDLAFSgitPYGYFLISACKDGKPMLRQGDTGDWIGTFLGHKGAVWGATLNKDATKAATAAADFTA 83
Cdd:COG2319   26 GALLLLLLGLAAAVASLAAS---PDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTV 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148727341  84 KVWDAVSGDELMTL-AHKHIVKTVDFTQDSNYLLTGGQDKLLRIYDLNKPEaEPKEISGHTSGIKKALWCSEDKQILSA- 161
Cdd:COG2319  103 RLWDLATGLLLRTLtGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGK-LLRTLTGHSGAVTSVAFSPDGKLLASGs 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148727341 162 DDKTVRLWDHATMTEVKSLN-FNMSVSSMEYIPEGEILVI-TYGRSIAFHSAVSLDPIKSFEAP-ATINSASLHPEKEFL 238
Cdd:COG2319  182 DDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKLLASgSADGTVRLWDLATGKLLRTLTGHsGSVRSVAFSPDGRLL 261

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 148727341 239 VAGGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSEDGTLRLWQTVVGKT 299
Cdd:COG2319  262 ASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKL 322
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 99-302 1.61e-36

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 133.23  E-value: 1.61e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148727341  99 HKHIVKTVDFTQDSNYLLTGGQDKLLRIYDLNKPEAEpKEISGHTSGIKKALWCSEDKQILSA-DDKTVRLWDHATMTEV 177
Cdd:cd00200    8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELL-RTLKGHTGPVRDVAASADGTYLASGsSDKTIRLWDLETGECV 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148727341 178 KSLN-FNMSVSSMEYIPEGEILVITYG-RSIAFHSAVSLDPIKSFEA-PATINSASLHPEKEFLVAGGEDFKLYKYDYNS 254
Cdd:cd00200   87 RTLTgHTSYVSSVAFSPDGRILSSSSRdKTIKVWDVETGKCLTTLRGhTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRT 166

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 148727341 255 GEELESYKGHFGPIHCVRFSPDGELYASGSEDGTLRLWQTVVGKTYGL 302
Cdd:cd00200  167 GKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGT 214
WD40 COG2319
WD40 repeat [General function prediction only];
43-298 2.44e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 113.85  E-value: 2.44e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148727341  43 LRQGDTGDWIGTFLGHKGAVWGATLNKDATKAATAAADFTAKVWDAVSGDELMTL-AHKHIVKTVDFTQDSNYLLTGGQD 121
Cdd:COG2319   20 LLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLlGHTAAVLSVAFSPDGRLLASASAD 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148727341 122 KLLRIYDLNKPEaEPKEISGHTSGIKkALWCSED-KQILSA-DDKTVRLWDHATMTEVKSLNFnmsvssmeyipegeilv 199
Cdd:COG2319  100 GTVRLWDLATGL-LLRTLTGHTGAVR-SVAFSPDgKTLASGsADGTVRLWDLATGKLLRTLTG----------------- 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148727341 200 itygrsiafHSAvsldpiksfeapaTINSASLHPEKEFLVAGGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGEL 279
Cdd:COG2319  161 ---------HSG-------------AVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKL 218

                        250
                 ....*....|....*....
gi 148727341 280 YASGSEDGTLRLWQTVVGK 298
Cdd:COG2319  219 LASGSADGTVRLWDLATGK 237
WD40 COG2319
WD40 repeat [General function prediction only];
4-130 2.16e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 67.63  E-value: 2.16e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148727341   4 RQTPLTCSGHTRPVVDLAFSgitPYGYFLISACKDGKPMLRQGDTGDWIGTFLGHKGAVWGATLNKDATKAATAAADFTA 83
Cdd:COG2319  278 GELLRTLTGHSGGVNSVAFS---PDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTV 354

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 148727341  84 KVWDAVSGDELMTL-AHKHIVKTVDFTQDSNYLLTGGQDKLLRIYDLN 130
Cdd:COG2319  355 RLWDLATGELLRTLtGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 254-292 2.35e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 55.01  E-value: 2.35e-10
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 148727341   254 SGEELESYKGHFGPIHCVRFSPDGELYASGSEDGTLRLW 292
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
255-292 1.90e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 52.35  E-value: 1.90e-09
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 148727341  255 GEELESYKGHFGPIHCVRFSPDGELYASGSEDGTLRLW 292
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 90-128 4.28e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.37  E-value: 4.28e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 148727341    90 SGDELMTL-AHKHIVKTVDFTQDSNYLLTGGQDKLLRIYD 128
Cdd:smart00320   1 SGELLKTLkGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 97-292 4.83e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 45.08  E-value: 4.83e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148727341  97 LAHKHIVKTVDFTQDSNYLLTGGQDKLLRIYDLNKPEAEPKEIS------GHTSGIKKALWCSEDK-QILSAD-DKTVRL 168
Cdd:PLN00181 480 LNSSNLVCAIGFDRDGEFFATAGVNKKIKIFECESIIKDGRDIHypvvelASRSKLSGICWNSYIKsQVASSNfEGVVQV 559

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148727341 169 WDHAT---MTEVKSlnFNMSVSSMEYIPEGEILVIT-----YGRSIAFHSAVSLDPIKSfeaPATINSASLHPEK-EFLV 239
Cdd:PLN00181 560 WDVARsqlVTEMKE--HEKRVWSIDYSSADPTLLASgsddgSVKLWSINQGVSIGTIKT---KANICCVQFPSESgRSLA 634

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 148727341 240 AGGEDFKLYKYDY-NSGEELESYKGHFGPIHCVRFSpDGELYASGSEDGTLRLW 292
Cdd:PLN00181 635 FGSADHKVYYYDLrNPKLPLCTMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKLW 687
WD40 pfam00400
WD domain, G-beta repeat;
91-128 2.40e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 2.40e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 148727341   91 GDELMTL-AHKHIVKTVDFTQDSNYLLTGGQDKLLRIYD 128
Cdd:pfam00400   1 GKLLKTLeGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 137-170 5.68e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 5.68e-04
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 148727341   137 KEISGHTSGIKKALWCSEDKQILSA-DDKTVRLWD 170
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGsDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
137-170 4.47e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 34.63  E-value: 4.47e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 148727341  137 KEISGHTSGIKKALWCSEDKQILSA-DDKTVRLWD 170
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGsDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 9-40 7.36e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 33.83  E-value: 7.36e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 148727341     9 TCSGHTRPVVDLAFSgitPYGYFLISACKDGK 40
Cdd:smart00320   7 TLKGHTGPVTSVAFS---PDGKYLASGSDDGT 35
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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