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Conserved domains on  [gi|6319818|ref|NP_009899|]
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Rrp7p [Saccharomyces cerevisiae S288C]

Protein Classification

dRRM_Rrp7p and RRP7_like domain-containing protein( domain architecture ID 10188308)

dRRM_Rrp7p and RRP7_like domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RRP7_like super family cl15166
RRP7 domain ribosomal RNA-processing protein 7 (Rrp7p), ribosomal RNA-processing protein 7 ...
 176-291 9.50e-37

RRP7 domain ribosomal RNA-processing protein 7 (Rrp7p), ribosomal RNA-processing protein 7 homolog A (Rrp7A), and similar proteins; This CD corresponds to the RRP7 domain of Rrp7p and Rrp7A. Rrp7p is encoded by YCL031C gene from Saccharomyces cerevisiae. It is an essential yeast protein involved in pre-rRNA processing and ribosome assembly, and is speculated to be required for correct assembly of rpS27 into the pre-ribosomal particle. Rrp7A, also termed gastric cancer antigen Zg14, is the Rrp7p homolog mainly found in Metazoans. The cellular function of Rrp7A remains unclear currently. Both Rrp7p and Rrp7A harbor an N-terminal RNA recognition motif (RRM), also termed RBD (RNA binding domain) or RNP (ribonucleoprotein domain), and a C-terminal RRP7 domain.


The actual alignment was detected with superfamily member cd12950:

Pssm-ID: 449475  Cd Length: 128  Bit Score: 127.40  E-value: 9.50e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319818  176 DIDYLKEDIHTHMAIFEQREAQAQEDVQ--SSIVDEDGFTLVVGKNTKSLNSIRKKIlnknPLSKHENKAKPISNIDKKA 253
Cdd:cd12950  15 PLEALQESVDSFMALFEAREEERKRERKrlRNEPDEDGFVTVVRGGRKGPAAGEEAG----KAAEEEKKEKEKKKKKKKE 90

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 6319818  254 KKDFYRFQVRERKKQEINQLLSKFKEDQERIKVMKAKR 291
Cdd:cd12950  91 LEDFYRFQLREKKKEEQADLLKKFEEDKERVEKMKEKR 128
dRRM_Rrp7p cd12293
deviant RNA recognition motif (dRRM) in yeast ribosomal RNA-processing protein 7 (Rrp7p) and ...
 8-146 1.54e-31

deviant RNA recognition motif (dRRM) in yeast ribosomal RNA-processing protein 7 (Rrp7p) and similar proteins; Rrp7p is encoded by YCL031C gene from Saccharomyces cerevisiae. It is an essential yeast protein involved in pre-rRNA processing and ribosome assembly, and is speculated to be required for correct assembly of rpS27 into the pre-ribosomal particle. Rrp7p contains a deviant RNA recognition motif (RRM), also termed RBD (RNA binding domain) or RNP (ribonucleoprotein domain), and a RRP7 domain. The classic RRM fold has a topology of beta1-alpha1-beta2-beta3-alpha2-beta4 with juxtaposed N- and C-termini. By contrast, the N-terminal region of Rrp7 displays a cyclic permutation of RRM topology: the strand equivalent to RRM beta4 is shuffled to the N-terminus of the strand equivalent to RRM beta1. Moreover, Rrp7 has an extra strand beta1, which, together with other four beta-strands, forms an antiparallel five-stranded beta-sheet.


:

Pssm-ID: 410983 [Multi-domain]  Cd Length: 105  Bit Score: 113.21  E-value: 1.54e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319818    8 AMKNGFIVVPFKLPDHKALPksqEASLHFMFAKRHQSSNS----NESDCLFLVNLPLLSNIEHMKKFVGQLCGKYDTVSH 83
Cdd:cd12293   1 AEINGFLVLPVTVPSPSASP---EKTTHYLYIRKHASKNPaetlPASRTLFLVNLPVDSTERHLRKLFGLGGGRIESVLH 77

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6319818   84 veellyndefglhevdlsaltsdlmsstdvnekryTPRNTALLKFVDAASINNCWNALKKYSN 146
Cdd:cd12293  78 -----------------------------------SSGSTAHVVFVDKASLDLAMKAIKKLVK 105
 
Name Accession Description Interval E-value
RRP7_Rrp7p cd12950
RRP7 domain ribosomal RNA-processing protein 7 (Rrp7p) and similar proteins; This CD ...
 176-291 9.50e-37

RRP7 domain ribosomal RNA-processing protein 7 (Rrp7p) and similar proteins; This CD corresponds to the RRP7 domain of Rrp7p. Rrp7p is encoded by YCL031C gene from Saccharomyces cerevisiae. It is an essential yeast protein involved in pre-rRNA processing and ribosome assembly. Rrp7p contains an N-terminal RNA recognition motif (RRM), also termed RBD (RNA binding domain) or RNP (ribonucleoprotein domain), and a C-terminal RRP7 domain.


Pssm-ID: 240577  Cd Length: 128  Bit Score: 127.40  E-value: 9.50e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319818  176 DIDYLKEDIHTHMAIFEQREAQAQEDVQ--SSIVDEDGFTLVVGKNTKSLNSIRKKIlnknPLSKHENKAKPISNIDKKA 253
Cdd:cd12950  15 PLEALQESVDSFMALFEAREEERKRERKrlRNEPDEDGFVTVVRGGRKGPAAGEEAG----KAAEEEKKEKEKKKKKKKE 90

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 6319818  254 KKDFYRFQVRERKKQEINQLLSKFKEDQERIKVMKAKR 291
Cdd:cd12950  91 LEDFYRFQLREKKKEEQADLLKKFEEDKERVEKMKEKR 128
dRRM_Rrp7p cd12293
deviant RNA recognition motif (dRRM) in yeast ribosomal RNA-processing protein 7 (Rrp7p) and ...
 8-146 1.54e-31

deviant RNA recognition motif (dRRM) in yeast ribosomal RNA-processing protein 7 (Rrp7p) and similar proteins; Rrp7p is encoded by YCL031C gene from Saccharomyces cerevisiae. It is an essential yeast protein involved in pre-rRNA processing and ribosome assembly, and is speculated to be required for correct assembly of rpS27 into the pre-ribosomal particle. Rrp7p contains a deviant RNA recognition motif (RRM), also termed RBD (RNA binding domain) or RNP (ribonucleoprotein domain), and a RRP7 domain. The classic RRM fold has a topology of beta1-alpha1-beta2-beta3-alpha2-beta4 with juxtaposed N- and C-termini. By contrast, the N-terminal region of Rrp7 displays a cyclic permutation of RRM topology: the strand equivalent to RRM beta4 is shuffled to the N-terminus of the strand equivalent to RRM beta1. Moreover, Rrp7 has an extra strand beta1, which, together with other four beta-strands, forms an antiparallel five-stranded beta-sheet.


Pssm-ID: 410983 [Multi-domain]  Cd Length: 105  Bit Score: 113.21  E-value: 1.54e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319818    8 AMKNGFIVVPFKLPDHKALPksqEASLHFMFAKRHQSSNS----NESDCLFLVNLPLLSNIEHMKKFVGQLCGKYDTVSH 83
Cdd:cd12293   1 AEINGFLVLPVTVPSPSASP---EKTTHYLYIRKHASKNPaetlPASRTLFLVNLPVDSTERHLRKLFGLGGGRIESVLH 77

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6319818   84 veellyndefglhevdlsaltsdlmsstdvnekryTPRNTALLKFVDAASINNCWNALKKYSN 146
Cdd:cd12293  78 -----------------------------------SSGSTAHVVFVDKASLDLAMKAIKKLVK 105
RRP7 pfam12923
Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain; RRP7 is an essential protein in ...
 176-296 1.52e-28

Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain; RRP7 is an essential protein in yeast that is involved in pre-rRNA processing and ribosome assembly. It is speculated to be required for correct assembly of rpS27 into the pre-ribosomal particle.


Pssm-ID: 432877  Cd Length: 119  Bit Score: 105.85  E-value: 1.52e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319818    176 DIDYLKEDIHTHMAIFEQREAQAQEDVQ--SSIVDEDGFTLVVGKntkSLNSIRKKILNKNPLSKHENKAKpisnidKKA 253
Cdd:pfam12923   6 DPEALQQEVDEYMEEFDAEEEEEKRERKkaRNEPDEDGFVTVTRG---GPGGARKEAAEEKIAKKEKKKKK------KKE 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 6319818    254 KKDFYRFQVRERKKQEINQLLSKFKEDQERIKVMKAKRKFNPY 296
Cdd:pfam12923  77 LLDFYRFQIREKKKNELAELRKKFEEDKEKIEKLKESRKFKPY 119
RRM_Rrp7 pfam17799
Rrp7 RRM-like N-terminal domain; This domain corresponds to the N-terminal RNA-binding domain ...
 12-146 1.24e-25

Rrp7 RRM-like N-terminal domain; This domain corresponds to the N-terminal RNA-binding domain found in the Rrp7 protein. It has an RRM-like fold with a circular permutation.


Pssm-ID: 436053  Cd Length: 162  Bit Score: 99.84  E-value: 1.24e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319818     12 GFIVVPFKLPdhkALPKSQEASLHFMFAKRHQSSNSNE--SDCLFLVNLPLLSNIEHMKKFVG-QLCGKydTVSHVEELL 88
Cdd:pfam17799   4 GFHVLPVRLP---PSPSLPKKATHYIYFKKHQTKNNDEasSRSLFLVNLPINTNFATLKKFFGtVALGA--TIESFVSSL 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319818     89 YNDEFGLHEVDLSALTSDLM--SSTDVNEKRYTPRNTALLKFVDAASINNCWNALKKYSN 146
Cdd:pfam17799  79 LTDEQEDVSIDLTKLTSDLDlqDETDDENEAKLPKNCGIVVFVDKSSFQLAFNCLKKLSK 138
 
Name Accession Description Interval E-value
RRP7_Rrp7p cd12950
RRP7 domain ribosomal RNA-processing protein 7 (Rrp7p) and similar proteins; This CD ...
 176-291 9.50e-37

RRP7 domain ribosomal RNA-processing protein 7 (Rrp7p) and similar proteins; This CD corresponds to the RRP7 domain of Rrp7p. Rrp7p is encoded by YCL031C gene from Saccharomyces cerevisiae. It is an essential yeast protein involved in pre-rRNA processing and ribosome assembly. Rrp7p contains an N-terminal RNA recognition motif (RRM), also termed RBD (RNA binding domain) or RNP (ribonucleoprotein domain), and a C-terminal RRP7 domain.


Pssm-ID: 240577  Cd Length: 128  Bit Score: 127.40  E-value: 9.50e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319818  176 DIDYLKEDIHTHMAIFEQREAQAQEDVQ--SSIVDEDGFTLVVGKNTKSLNSIRKKIlnknPLSKHENKAKPISNIDKKA 253
Cdd:cd12950  15 PLEALQESVDSFMALFEAREEERKRERKrlRNEPDEDGFVTVVRGGRKGPAAGEEAG----KAAEEEKKEKEKKKKKKKE 90

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 6319818  254 KKDFYRFQVRERKKQEINQLLSKFKEDQERIKVMKAKR 291
Cdd:cd12950  91 LEDFYRFQLREKKKEEQADLLKKFEEDKERVEKMKEKR 128
dRRM_Rrp7p cd12293
deviant RNA recognition motif (dRRM) in yeast ribosomal RNA-processing protein 7 (Rrp7p) and ...
 8-146 1.54e-31

deviant RNA recognition motif (dRRM) in yeast ribosomal RNA-processing protein 7 (Rrp7p) and similar proteins; Rrp7p is encoded by YCL031C gene from Saccharomyces cerevisiae. It is an essential yeast protein involved in pre-rRNA processing and ribosome assembly, and is speculated to be required for correct assembly of rpS27 into the pre-ribosomal particle. Rrp7p contains a deviant RNA recognition motif (RRM), also termed RBD (RNA binding domain) or RNP (ribonucleoprotein domain), and a RRP7 domain. The classic RRM fold has a topology of beta1-alpha1-beta2-beta3-alpha2-beta4 with juxtaposed N- and C-termini. By contrast, the N-terminal region of Rrp7 displays a cyclic permutation of RRM topology: the strand equivalent to RRM beta4 is shuffled to the N-terminus of the strand equivalent to RRM beta1. Moreover, Rrp7 has an extra strand beta1, which, together with other four beta-strands, forms an antiparallel five-stranded beta-sheet.


Pssm-ID: 410983 [Multi-domain]  Cd Length: 105  Bit Score: 113.21  E-value: 1.54e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319818    8 AMKNGFIVVPFKLPDHKALPksqEASLHFMFAKRHQSSNS----NESDCLFLVNLPLLSNIEHMKKFVGQLCGKYDTVSH 83
Cdd:cd12293   1 AEINGFLVLPVTVPSPSASP---EKTTHYLYIRKHASKNPaetlPASRTLFLVNLPVDSTERHLRKLFGLGGGRIESVLH 77

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6319818   84 veellyndefglhevdlsaltsdlmsstdvnekryTPRNTALLKFVDAASINNCWNALKKYSN 146
Cdd:cd12293  78 -----------------------------------SSGSTAHVVFVDKASLDLAMKAIKKLVK 105
RRP7_like cd12932
RRP7 domain ribosomal RNA-processing protein 7 (Rrp7p), ribosomal RNA-processing protein 7 ...
 168-284 9.58e-29

RRP7 domain ribosomal RNA-processing protein 7 (Rrp7p), ribosomal RNA-processing protein 7 homolog A (Rrp7A), and similar proteins; This CD corresponds to the RRP7 domain of Rrp7p and Rrp7A. Rrp7p is encoded by YCL031C gene from Saccharomyces cerevisiae. It is an essential yeast protein involved in pre-rRNA processing and ribosome assembly, and is speculated to be required for correct assembly of rpS27 into the pre-ribosomal particle. Rrp7A, also termed gastric cancer antigen Zg14, is the Rrp7p homolog mainly found in Metazoans. The cellular function of Rrp7A remains unclear currently. Both Rrp7p and Rrp7A harbor an N-terminal RNA recognition motif (RRM), also termed RBD (RNA binding domain) or RNP (ribonucleoprotein domain), and a C-terminal RRP7 domain.


Pssm-ID: 240576 [Multi-domain]  Cd Length: 118  Bit Score: 106.57  E-value: 9.58e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319818  168 FVNFYKPL--DIDYLKEDIHTHMAIFEQREAQAQEDVQ--SSIVDEDGFTLVVGKNTKSLNSIRKKILNKnPLSKHENKA 243
Cdd:cd12932   5 WVAEYKRSrpDPAELQSEVDEYMEEFDKREEEEKEEAKeaRNEPDEDGFVTVTRGGRKGKTAREEAVEAK-AKEKEKKKK 83

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 6319818  244 KpisnidKKAKKDFYRFQVRERKKQEINQLLSKFKEDQERI 284
Cdd:cd12932  84 K------KKELEDFYRFQIREKKKEELAELRKKFEEDKKRI 118
RRP7 pfam12923
Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain; RRP7 is an essential protein in ...
 176-296 1.52e-28

Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain; RRP7 is an essential protein in yeast that is involved in pre-rRNA processing and ribosome assembly. It is speculated to be required for correct assembly of rpS27 into the pre-ribosomal particle.


Pssm-ID: 432877  Cd Length: 119  Bit Score: 105.85  E-value: 1.52e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319818    176 DIDYLKEDIHTHMAIFEQREAQAQEDVQ--SSIVDEDGFTLVVGKntkSLNSIRKKILNKNPLSKHENKAKpisnidKKA 253
Cdd:pfam12923   6 DPEALQQEVDEYMEEFDAEEEEEKRERKkaRNEPDEDGFVTVTRG---GPGGARKEAAEEKIAKKEKKKKK------KKE 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 6319818    254 KKDFYRFQVRERKKQEINQLLSKFKEDQERIKVMKAKRKFNPY 296
Cdd:pfam12923  77 LLDFYRFQIREKKKNELAELRKKFEEDKEKIEKLKESRKFKPY 119
RRM_Rrp7 pfam17799
Rrp7 RRM-like N-terminal domain; This domain corresponds to the N-terminal RNA-binding domain ...
 12-146 1.24e-25

Rrp7 RRM-like N-terminal domain; This domain corresponds to the N-terminal RNA-binding domain found in the Rrp7 protein. It has an RRM-like fold with a circular permutation.


Pssm-ID: 436053  Cd Length: 162  Bit Score: 99.84  E-value: 1.24e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319818     12 GFIVVPFKLPdhkALPKSQEASLHFMFAKRHQSSNSNE--SDCLFLVNLPLLSNIEHMKKFVG-QLCGKydTVSHVEELL 88
Cdd:pfam17799   4 GFHVLPVRLP---PSPSLPKKATHYIYFKKHQTKNNDEasSRSLFLVNLPINTNFATLKKFFGtVALGA--TIESFVSSL 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319818     89 YNDEFGLHEVDLSALTSDLM--SSTDVNEKRYTPRNTALLKFVDAASINNCWNALKKYSN 146
Cdd:pfam17799  79 LTDEQEDVSIDLTKLTSDLDlqDETDDENEAKLPKNCGIVVFVDKSSFQLAFNCLKKLSK 138
RRP7_Rrp7A cd12951
RRP7 domain ribosomal RNA-processing protein 7 homolog A (Rrp7A) and similar proteins; The ...
 176-296 4.11e-25

RRP7 domain ribosomal RNA-processing protein 7 homolog A (Rrp7A) and similar proteins; The family corresponds to the RRP7 domain of Rrp7A, also termed gastric cancer antigen Zg14, and similar proteins which are yeast ribosomal RNA-processing protein 7 (Rrp7p) homologs mainly found in Metazoans. The cellular function of Rrp7A remains unclear currently. Rrp7A harbors an N-terminal RNA recognition motif (RRM), also termed RBD (RNA binding domain) or RNP (ribonucleoprotein domain), and a C-terminal RRP7 domain.


Pssm-ID: 240578 [Multi-domain]  Cd Length: 129  Bit Score: 97.35  E-value: 4.11e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319818  176 DIDYLKEDIHTHMAIFEQREAQAQEDVQ-SSIVDEDGFTlVVGKNTKSLNSIRKKILNKNPLSKHENKAKpisnidKKAK 254
Cdd:cd12951  15 DPAELQSEIDEYMEEYDKEEEEEKEEKEkEAEPDEDGWV-TVTKKGRRPKTARKESVAAKAAEKEKKKKK------KKEL 87

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 6319818  255 KDFYRFQVRERKKQEINQLLSKFKEDQERIKVMKAKRKFNPY 296
Cdd:cd12951  88 KNFYRFQIRESKRNELAELRKKFEEDKKRIALLKAARKFKPY 129
Cas_DxTHG pfam09455
CRISPR-associated (Cas) DxTHG family; CRISPR is a term for Clustered Regularly Interspaced ...
 154-295 7.51e-03

CRISPR-associated (Cas) DxTHG family; CRISPR is a term for Clustered Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR associated) proteins. The family describes Cas proteins of about 400 residues that include the motif [VIL]-D-x-[ST]-H-[GS]. The CRISPR and associated proteins are thought to be involved in the evolution of host resistance. The exact molecular function of this family is currently unknown.


Pssm-ID: 401419 [Multi-domain]  Cd Length: 313  Bit Score: 37.49  E-value: 7.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319818    154 ELFEWTYTTPSFTTFvnfykpLDIDYLKEDIHTHMAIFEQREAQAQEDVQSSIvDEDGFTLVVGKNTKSLNSIRKKILNK 233
Cdd:pfam09455 163 ELLDWTTAVDRFLNT------GDAEKLAELLSIEKKSLLKESPTRLKKLASLL-EEFSDALELGRPLEVLKIEIEKIVEK 235

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6319818    234 N-------PLSKHENKAKPISNIDKKAKKDFYRFQVRERKKQEINQLLSKFKEDQERIKVMKAKRKFNP 295
Cdd:pfam09455 236 LkeelerlTILEEEEAAPPLELLLDEIKKELEPFLDKDKRREEIEEALNNLSKVEKKLSREKEKISSEL 304
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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