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Conserved domains on  [gi|6319944|ref|NP_010025|]
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uncharacterized protein YCR101C [Saccharomyces cerevisiae S288C]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
VPS10 super family cl33391
VPS10 domain;
36-166 1.08e-17

VPS10 domain;


The actual alignment was detected with superfamily member smart00602:

Pssm-ID: 214740 [Multi-domain]  Cd Length: 612  Bit Score: 79.76  E-value: 1.08e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319944      36 SFNLVSFDDSNtsirldgwgvVWISFDAGENWETVKEIEERIFR-FTVDPFHGQERGFAFICESPKFYITDDRGESWRAL 114
Cdd:smart00602   1 SLLLGSAEESS----------VYISEDYGKTWKKIDEIEGVIIEtVISDFFNSSANKFKTILVKGYIFISSDEGKSFQKF 70

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 6319944     115 TIPSSEeyLDGDCFITTHPRNKELLIANCYSYMidadvlydpseIYLSNDGN 166
Cdd:smart00602  71 TLPFPP--LPSLLYHPKHPDYVLAYSKDCNYKV-----------LYVSKDFG 109
 
Name Accession Description Interval E-value
VPS10 smart00602
VPS10 domain;
36-166 1.08e-17

VPS10 domain;


Pssm-ID: 214740 [Multi-domain]  Cd Length: 612  Bit Score: 79.76  E-value: 1.08e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319944      36 SFNLVSFDDSNtsirldgwgvVWISFDAGENWETVKEIEERIFR-FTVDPFHGQERGFAFICESPKFYITDDRGESWRAL 114
Cdd:smart00602   1 SLLLGSAEESS----------VYISEDYGKTWKKIDEIEGVIIEtVISDFFNSSANKFKTILVKGYIFISSDEGKSFQKF 70

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 6319944     115 TIPSSEeyLDGDCFITTHPRNKELLIANCYSYMidadvlydpseIYLSNDGN 166
Cdd:smart00602  71 TLPFPP--LPSLLYHPKHPDYVLAYSKDCNYKV-----------LYVSKDFG 109
Sortilin-Vps10 pfam15902
Sortilin, neurotensin receptor 3,; Sortilin, also known in mammals as neurotensin receptor-3, ...
 55-144 4.23e-14

Sortilin, neurotensin receptor 3,; Sortilin, also known in mammals as neurotensin receptor-3, is the archetypical member of a Vps10-domain (Vps10-D) that binds neurotrophic factors and neuropeptides. This domain constitutes the entire luminal part of Sortilin and is activated in the trans-Golgi network by enzymatic propeptide cleavage. The structure of the domain has been determined as a ten-bladed propeller, with up to 9 BNR or beta-hairpin turns in it. The mature receptor binds various ligands, including its own propeptide (Sort-pro), neurotensin, the pro-forms of nerve growth factor-beta (NGF)6 and brain-derived neurotrophic factor (BDNF)7, lipoprotein lipase (LpL), apo lipoprotein AV14 and the receptor-associated protein (RAP)1.


Pssm-ID: 464929 [Multi-domain]  Cd Length: 444  Bit Score: 69.15  E-value: 4.23e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319944     55 GVVWISFDAGENWETVKEI--EERIFRFTVDPFHGQeRGFaFICESPKFYITDDRGESWRALTIPSSEeyLDGDCFITTH 132
Cdd:pfam15902   1 SEVYRSHDYGKTWKKVKDVpdGEAILAIYPHPYDND-RAY-LLTDGKKHYYTTDRGKTFRSFKLPFPP--NLFGPPLSFH 76

                          90
                  ....*....|..
gi 6319944    133 PRNKELLIANCY 144
Cdd:pfam15902  77 PKDPDWLIWYGG 88
COG4447 COG4447
Uncharacterized conserved protein related to plant photosystem II stability/assembly factor ...
 36-124 6.09e-06

Uncharacterized conserved protein related to plant photosystem II stability/assembly factor [General function prediction only];


Pssm-ID: 443546 [Multi-domain]  Cd Length: 156  Bit Score: 44.22  E-value: 6.09e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319944   36 SFNLVSFDDSNTSIRLDGWGVVWISFDAGENWETVKEIEERIFRFTVDpFHGQERGFAFIcesPKFYITDDRGESWRALT 115
Cdd:COG4447  36 SLRAVAFSDPNTVWVGTGPGGIYRSTDGGKTWTEVNSGPDNPRLFAIA-FSDPNTGYAAV---GGIYRTTDGGKTWTKVS 111


                ....*....
gi 6319944  116 IPSSEEYLD 124
Cdd:COG4447 112 SGLPVDLND 120
 
Name Accession Description Interval E-value
VPS10 smart00602
VPS10 domain;
36-166 1.08e-17

VPS10 domain;


Pssm-ID: 214740 [Multi-domain]  Cd Length: 612  Bit Score: 79.76  E-value: 1.08e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319944      36 SFNLVSFDDSNtsirldgwgvVWISFDAGENWETVKEIEERIFR-FTVDPFHGQERGFAFICESPKFYITDDRGESWRAL 114
Cdd:smart00602   1 SLLLGSAEESS----------VYISEDYGKTWKKIDEIEGVIIEtVISDFFNSSANKFKTILVKGYIFISSDEGKSFQKF 70

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 6319944     115 TIPSSEeyLDGDCFITTHPRNKELLIANCYSYMidadvlydpseIYLSNDGN 166
Cdd:smart00602  71 TLPFPP--LPSLLYHPKHPDYVLAYSKDCNYKV-----------LYVSKDFG 109
Sortilin-Vps10 pfam15902
Sortilin, neurotensin receptor 3,; Sortilin, also known in mammals as neurotensin receptor-3, ...
 55-144 4.23e-14

Sortilin, neurotensin receptor 3,; Sortilin, also known in mammals as neurotensin receptor-3, is the archetypical member of a Vps10-domain (Vps10-D) that binds neurotrophic factors and neuropeptides. This domain constitutes the entire luminal part of Sortilin and is activated in the trans-Golgi network by enzymatic propeptide cleavage. The structure of the domain has been determined as a ten-bladed propeller, with up to 9 BNR or beta-hairpin turns in it. The mature receptor binds various ligands, including its own propeptide (Sort-pro), neurotensin, the pro-forms of nerve growth factor-beta (NGF)6 and brain-derived neurotrophic factor (BDNF)7, lipoprotein lipase (LpL), apo lipoprotein AV14 and the receptor-associated protein (RAP)1.


Pssm-ID: 464929 [Multi-domain]  Cd Length: 444  Bit Score: 69.15  E-value: 4.23e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319944     55 GVVWISFDAGENWETVKEI--EERIFRFTVDPFHGQeRGFaFICESPKFYITDDRGESWRALTIPSSEeyLDGDCFITTH 132
Cdd:pfam15902   1 SEVYRSHDYGKTWKKVKDVpdGEAILAIYPHPYDND-RAY-LLTDGKKHYYTTDRGKTFRSFKLPFPP--NLFGPPLSFH 76

                          90
                  ....*....|..
gi 6319944    133 PRNKELLIANCY 144
Cdd:pfam15902  77 PKDPDWLIWYGG 88
COG4447 COG4447
Uncharacterized conserved protein related to plant photosystem II stability/assembly factor ...
 36-124 6.09e-06

Uncharacterized conserved protein related to plant photosystem II stability/assembly factor [General function prediction only];


Pssm-ID: 443546 [Multi-domain]  Cd Length: 156  Bit Score: 44.22  E-value: 6.09e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319944   36 SFNLVSFDDSNTSIRLDGWGVVWISFDAGENWETVKEIEERIFRFTVDpFHGQERGFAFIcesPKFYITDDRGESWRALT 115
Cdd:COG4447  36 SLRAVAFSDPNTVWVGTGPGGIYRSTDGGKTWTEVNSGPDNPRLFAIA-FSDPNTGYAAV---GGIYRTTDGGKTWTKVS 111


                ....*....
gi 6319944  116 IPSSEEYLD 124
Cdd:COG4447 112 SGLPVDLND 120
COG4447 COG4447
Uncharacterized conserved protein related to plant photosystem II stability/assembly factor ...
 44-125 7.05e-03

Uncharacterized conserved protein related to plant photosystem II stability/assembly factor [General function prediction only];


Pssm-ID: 443546 [Multi-domain]  Cd Length: 156  Bit Score: 35.36  E-value: 7.05e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319944   44 DSNTSIRLDGWGVVWISFDAGENWETVkeieerifrfTVDPFHGQERGFAFI--------CESPKFYITDDRGESWRALT 115
Cdd:COG4447   2 DGNRLWAVGASGGILRSTDGGKTWTPL----------SDGLPGLSLRAVAFSdpntvwvgTGPGGIYRSTDGGKTWTEVN 71

                        90
                ....*....|
gi 6319944  116 IPSSEEYLDG 125
Cdd:COG4447  72 SGPDNPRLFA 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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